Effects of Radiation at the Cellular Level
Effects of Radiation at the
Cellular Level
10/25/2010
1
Table of Contents
Topic
Slide Number
Cellular Components
Chromosomes DNA and RNA
Apoptosis
Cells Life Cycle
Interaction of Radiation with Cellular Components
Direct and Indirect Effects
DNA Damage and Repair
Chromosomal Aberrations
Cytogenetic Dosimetry
Consequences of Damage to DNA
Cell Survival Curves
Factors Affecting Radiosensitivity
References
3
17
25
31
43
52
56
71
80
85
90
100
129
2
Cellular Components
3
General
The cell is the basic
building block of
biological systems.
There are ca. 1014
Th
cells in the human
body.
A typical cell is 10 to
20 um in size.
4
Cell Membrane (plasma membrane)
A thin bilayer of phospholipids surrounding the cell.
It serves as a passive barrier impenetrable to most
polar molecules (water is an exception).
Proteins distributed throughout the membrane
actively control the movement of many ions and
molecules into and out of the cell
5
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