AIP–History of Immunization in Alberta–History of ...

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

August 31, 2016

History of Immunization in Alberta

The history of provincially funded vaccines used in Alberta is outlined below and provides date ranges for when an immunological product was in use in Alberta and/or when the product was approved for use in Canada.

History of Biologicals Administered in Alberta (Updated August 2016)

Biological Name/Description/Trade Name

Manufacturer

Bacillus Calmette-Gu?rin (TB): BCG Connaught Vaccine (freeze-dried)

Botulism Antitoxin

Multiple manufacturers

Botulism Antitoxin: Bivalent A & B Botulism Antitoxin: Type E

Connaught/ Sanofi Pasteur

Botulism Antitoxin ? Behring (Equine) Types A, B, & E

Novartis

Botulism Immune Globulin

California Department

Intravenous (Human) - BabyBIG? of Public Health

Diphtheria Antitoxin

Multiple manufacturers

Diphtheria Antitoxin: ANTIDIPHTHERIA SERUM

Instituto Butantan, Brazil

Diphtheria Antitoxin (equine)

Institute of Immunology Inc Croatia

Diphtheria Antitoxin (equine)

VINS Bioproducts Limited, India

Diphtheria Reaction Test

Diphtheria Toxoid

Diphtheria Toxoid (fluid)

Diphtheria Toxoid (fluid-diluted)

Diphtheria Toxoid and Pertussis Combined

Diphtheria/Tetanus Toxoids (pediatric)

Vaccine Code BCG BA BA

BA BAIG DA DA DA

DA DRT

D DD No code DT

Start Date (Y-M-D)

1956-01-01 1962-06-12

unknown

2011-10-27 2013-05-27 1895-01-01 2006-03-08 2011-04-21

2014-06-11 1923-01-01

1930 1954-04-01 1954-04-01

1943 1948-01-01

End Date (Y-M-D) 2007-08-09

2011-10-26

2010-10-31 2014-03-31

1996-01-01 1994-08-01 1994-08-01 1994-08-01 1948-01-01 1998-12-31

? 2007?2016 Government of Alberta

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Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Diphtheria/Tetanus/Acellular Pertussis: TRIPACEL

Connaught/ Aventis Pasteur

Diphtheria/Tetanus/Acellular Pertussis: ADACEL?

Sanofi Pasteur

Diphtheria/Tetanus/Acellular Pertussis: BOOSTRIX?

GlaxoSmithKline

Diphtheria/Tetanus/Acellular Pertussis/IPV: QUADRACEL?

Diphtheria/Tetanus/Acellular Pertussis/IPV: INFANRIXTM-IPV

Connaught/ Sanofi Pasteur

GlaxoSmithKline

Diphtheria/Tetanus/Acellular Pertussis/IPV: BOOSTRIX?-IPV

GlaxoSmithKline

Diphtheria/Tetanus/Acellular Pertussis/IPV/Hib: PENTACEL?

Diphtheria/Tetanus/Acellular Pertussis/IPV/Hib: PEDIACEL?

Connaught/ Sanofi Pasteur

Sanofi Pasteur

Diphtheria/Tetanus/Acellular Pertussis/IPV/Hib: INFANRIXTMIPV/Hib

Diphtheria/Tetanus/Acellular Pertussis/IPV/Hib/Hepatitis B: INFANRIX hexa?

GlaxoSmithKline GlaxoSmithKline

Diphtheria/Tetanus/IPV (pediatric) Connaught

Diphtheria/Whole Cell Pertussis/Tetanus

Diphtheria/Whole Cell Pertussis/Tetanus/IPV: QUAD

Connaught

Diphtheria/Whole Cell

Connaught

Pertussis/Tetanus/IPV/Hib: PENTA

Diphtheria/Whole Cell Pertussis/Tetanus/IPV/Killed Measles: Quint

Hepatitis A ? adult: HAVRIX? 1440 GlaxoSmithKline

and VAQTA?

Merck Frosst

Hepatitis A pediatric: HAVRIX? 720 GlaxoSmithKline

and VAQTA?

Merck Frost

Vaccine Code

DTaP

Start Date (Y-M-D)

1997-07-01

August 31, 2016

End Date (Y-M-D) 1999-01-01

dTap

2004-09-01

dTap

2008-11-30

DTaP-IPV 1997-07-01

DTaP-IPV 2012-11-20

dTap-IPV 2012-10-11

DTaP-IPV- 1997-07-01 Hib

DTaP-IPV- 2007-11-30 Hib

DTaP-IPV- 2012-11-20 Hib

2007-11-30

DTaP-IPV- 2016-06-01 HIB-HB

DT-IPV DPT

1996-07-01 1948-01-01

2005-10-01 1997-06-30

DPTP

1994-08-02 1997-06-30

DPTPHib 1994-08-02 1997-06-30

No code

1968-01

1970-07

HAV HAV

1994-01-01 1997-06-01

? 2007?2016 Government of Alberta

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Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Vaccine Code

Start Date (Y-M-D)

Hepatitis A ? AVAXIM? Pediatric (outbreak in Edmonton)

Sanofi Pasteur Ltd.

Hepatitis A and B combined: TWINRIX?

GlaxoSmithKline

Hepatitis B: RECOMBIVAX HB? (neonatal program ? infants at high risk)

Merck Frosst

Hepatitis B: RECOMBIVAX HB? (3 Merck Canada mL multi-dose vials with thimerosal) (Grade 5)

Hepatitis B: RECOMBIVAX HB? Thimerosal free (infants younger than age one)

Merck Frosst

Hepatitis B: ENGERIX? B Adult for GlaxoSmithKline individuals allergic to thimerosal

Hepatitis B: ENGERIX? Pediatric GlaxoSmithKline

HAV

2013-02

HABV

1997-01-01

HBV

1983-01-01

HBV

1995-09

HBTmf 2002-05-01

HBV HBV

2002 2011

Hepatitis B for Dialysis Hepatitis B Immune Globulin

Haemophilus influenzae type b: bCAPSA Haemophilus influenzae type b (PRP) Haemophilus influenzae type b Haemophilus influenzae type b

Merck Frosst

Multiple manufacturers ? accessed through Canadian Blood Services

Mead Johnson

HBVD HBIG

Unknown

1983-01-01 1971-01-01

1987-08-01

Connaught

PRP

1987-10-01

Connaught Merck Frosst

PRPD OMP

1988-03-16 1990-01-01

Haemophilus influenzae type b

Haemophilus influenzae type b PRPT: Act-HIB?

Haemophilus influenzae type b: HIBERIX?

Human Papillomavirus Quadrivalent: GARDASIL? (Grade 5) (Grade 9 catch up 2009-09)

Human Papillomavirus Quadrivalent: GARDASIL?9

Lederle-Praxis Connaught/ Sanofi Pasteur GlaxoSmithKline Merck Canada

Merck Canada

HbOC Hib

1992-05-19 1993-02-01

Hib

2013-01-22

HPV HPV9

2008-09-01 (girls)

2014-09-01 (boys)

2016-09-01

August 31, 2016

End Date (Y-M-D)

2010-10-31 2011-05-01

1987-10-01 1988-03-01 1992-05-18 1994-08-02 1993-02-01

2015-08-31

? 2007?2016 Government of Alberta

Page 3 of 8

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Immune Serum Globulin (human)

Influenza whole cell: FLUVIRAL? & VAXIGRIP?

Multiple manufacturers

GlaxoSmithKline Sanofi Pasteur

Influenza split virus vaccine: FLUVIRAL? & VAXIGRIP? (first used in Canada in approximately 1992)

Biochem/ GlaxoSmithKline Connaught/ Sanofi Pasteur

Influenza H1N1 Pandemic

GlaxoSmithKline

adjuvanted: AREPANRIXTM H1N1 ?

universal immunization

Influenza H1N1 Pandemic without CSL Australia adjuvant - pregnant women

Influenza A (H1N1) 2009 Pandemic Monovalent Vaccine (without adjuvant) ? pregnant women and individuals 10 to 64 years without immune compromising conditions and who specifically request vaccine without adjuvant.

GlaxoSmithKline

Influenza Trivalent: AGRIFLU?

Novartis

Influenza Trivalent: FLUAD?

Novartis

Influenza Trivalent INFLUVAC?

BGP Pharma ULC

Influenza Inactivated Quadrivalent: Sanofi Pasteur Inc FLUZONE?

Influenza Live attenuated: FLUMIST? Quadrivalent

AstraZeneca

Influenza Live attenuated trivalent: FLUMIST? ? Pilot/Research 2011 2012 influenza season included 2000 doses

AstraZeneca

Influenza Live attenuated trivalent: FLUMIST? - Vaccine of choice for children 2 ? 17 years of age

AstraZeneca

Influenza Live attenuated quadrivalent vaccine: FLUMIST? QUADRIVALENT - Vaccine of choice for children 2 ? 17 years of age

AstraZeneca

Vaccine Code

IG

Start Date (Y-M-D)

1987-02-18

August 31, 2016

End Date (Y-M-D)

FLU

1943-01-01 1992 approx.

FLU

1992

approx.

H1N1-09-AD 2009-10-19 2010-10-31

H1N1-09

2009-11

H1N1-09 2009-12-01

2009-11 2010-08

FLU

2011-10

2014-09

FLU

2015-10

FLU

2015-10

FLU

2014-10

FLU

2011-10

2012-03

FLU

2012-10

FLU

2014-10

? 2007?2016 Government of Alberta

Page 4 of 8

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

E/Z Measles (Live)

Killed Red Measles

Measles (Red) dose measles catchup for Grades 1 to 9)

Measles/Mumps/Rubella: M-M-R? II (12 months of age routine program)

Merck Frosst

Measles/Mumps/Rubella (PRIORIX?)

GlaxoSmithKline

Measles/Mumps/Rubella/Varicella (PRIORIX-TETRA?) ? replacing MMR as routine program at 12 months of age

GlaxoSmithKline

Measles/Mumps/Rubella/Varicella Merck Canada (ProQuadTM)

Measles/Rubella (second dose measles catch-up, Grades 1 to 9)

Meningococcal B Multicomponent Novartis Vaccines Recombinant Vaccine: BEXSERO? and Diagnostics Inc.

Meningococcal Conjugate monovalent C (Campaign: 2 ? 24 months of age)

Meningococcal Conjugate monovalent C (Universal Infant Program for infants born on or after 2001/09/01) Menjugate?

Novartis

Meningococcal Conjugate monovalent C: NeisVacC?

GlaxoSmithKline

Meningococcal Conjugate Polysaccharide (A, C, Y, W-135) (Menactra?) - High-risk groups

Sanofi Pasteur

Meningococcal (Groups A, C, W135 and Y) Conjugate ? (MENVEOTM)

Novartis

Meningococcal Polysaccharide Bivalent A, C (Campaign - 2 to 24 years of age)

Vaccine Code EZM KMEA MEA

Start Date (Y-M-D)

1969-01-01 1966

1970/07

MMR

1982-10-01

MMR MMR-Var

1999 (approx.)

2010-08-01

MMR-Var 2014-05-13

MR

1997-01-01

Men-B 2014-09-23

MenconC 2001-11-01

MenconC 2002-04-04

MenconC

2005-10

MenCACYW

2007-02-01

MenCACYW

2011-02

MenAC MeninAC

2001-02-06

August 31, 2016

End Date (Y-M-D) 1971-01-01 1970-07 1998-12-31

1999-04-30 2002-03-31

2002-03-01

? 2007?2016 Government of Alberta

Page 5 of 8

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Meningococcal polysaccharide (quadrivalent A, C, Y, W-135) high-risk groups (MENOMUNE?)

Connaught/ Sanofi Pasteur

Meningococcal Polysaccharide (quadrivalent A, C, Y, W-135) Campaign

Mumps: MUMPSVAX

Merck Frosst

Pertussis Acellular ? Acel-P

Wyeth-Ayerst

Pertussis Whole Cell

Pneumococcal Conjugate ? 7 Valent: PREVNAR? (routine infant program: 4 dose series)

Wyeth

Pneumococcal Conjugate - 13 Valent: PREVNAR? 13 (replaced 7 valent vaccine for infant program: 3 dose series)

Wyeth

Pneumococcal Polysaccharide: PNEUMOVAX? 23 (high-risk groups except 65 years of age and older)

Merck Frosst

Pneumococcal Polysaccharide: Pneumo 23?

Sanofi Pasteur

Polio Inactivated (Salk) - vaccine trials: pre-licensure

Polio Inactivated (Salk)

Polio Inactivated (Salk) diploid cell

Polio Inactivated (Salk) Vero Cell Origin: IMOVAX? Polio

Polio Oral (Sabin)

Rabies Vaccine

Sanofi Pasteur

Connaught Multiple manufacturers

Vaccine Code

Start Date (Y-M-D)

MENING-P 1983-05-04

August 31, 2016

End Date (Y-M-D) 2012-01-18

MENING-P (single dose)

MENOTET (multi-dose)

2000-02-15

MU

1982-01-01

aP

1997-07-01

P

1939-01-01

PNEU-C 2002-09-01

2002-03-01

2004-02-08 2001-10

1997-06-30 2010-06-30

PNEU-C13 2010-07-01

PNEUMOP

1997-04

PNEUMOP

IPV

1997-04 1954

2008-09 Unknown

IPV

1956-01-01

IPV

Unknown

2007-04-30

(vaccine

introduced in

Canada 1989)

IPV

2007-04-09

OPV RAB

1962-01-01 1980-01-01

1994-07-31

? 2007?2016 Government of Alberta

Page 6 of 8

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Rabies HDCV: IMOVAX? Rabies Sanofi Pasteur

Vaccine Code

RAB

Rabies PCECV: RabAvert?

Novartis

Rabies Immune Globulin

Multiple manufacturers

Rabies Immune Globulin: IMOGAM? Rabies

Sanofi Pasteur

Rabies Immune Globulin: HYPERRAB? S/D

Talecris Therapeutics/ Grifols Therapeutics

Rotavirus vaccine: ROTARIX?

Merck Canada Inc.

Rubella

Connaught

Smallpox (vaccinia) - universal

Smallpox (vaccinia) - select groups

Snakebite Antivenom

Tetanus/Diphtheria Toxoids (adult) Sanofi Pasteur

Tetanus Immune Globulin (Human) Multiple manufacturers

Tetanus Immune Globulin (Human): Talecris Therapeutics/

HYPERTET? S/D

Grifols Therapeutics

Tetanus/Diphtheria/IPV (adult)

Sanofi Pasteur Limited

Tetanus Polio

Tetanus Toxoid

Tuberculin Purified Protein

Connaught/

Derivative 5TU (Mantoux ? TB Test) Sanofi Pasteur

Typhoid injectable: TYPHERIX?

GlaxoSmithKline

Typhoid injectable: TYPHIM Vi?

Sanofi Pasteur S/A

RAB RIG

RIG

RIG

Rot RUB Sma Sma SNAKE Td TIG

TIG

TdP

TP TT PPD

TYVI TYVI

Varicella Zoster: VARIVAX? II and Merck Frosst

VZ

III (one year of age ? phased in

approach)

Start Date (Y-M-D) 1999-08 approx.

2005-06-01 1983-09-16

2004 -2005

2007-07

2015-06-01 1971-01-01 1870-01-01 2005-01-01 1980-01-01 1980-07-09

unknown

2006-07

2015-02-11

1959-01-01 1947-01-01 1960-01-05

2004-01-19 2013-0904 2001-0701

August 31, 2016

End Date (Y-M-D)

1998-10-01 1980-04-10 2002-03-20

2006-06

1994-08-01 2000-12-31

? 2007?2016 Government of Alberta

Page 7 of 8

Alberta Health, Public Health and Compliance Division Alberta Immunization Policy ? History of Immunization In Alberta History of Biologicals Administered in Alberta

Biological Name/Description/Trade Name

Manufacturer

Varicella Zoster: VARILRIX?

GlaxoSmithKline

Varicella Immune Globulin

Multiple manufacturers ? accessed through Canadian Blood Services

Vaccine Code VZ VZIG

Start Date (Y-M-D) unknown

1985-01-01

August 31, 2016

End Date (Y-M-D)

*Not all vaccine manufacturers are known or multiple manufacturers have supplied the biological product over the years since first introduced.

For additional information, please contact the manufacturer of the product and/or Health Canada.

References

1 Alberta Health. (2016, February). Immunization Data Submission and Response Guidelines, Version 5.8.

2 Alberta Health and Wellness, Disease Control and Prevention. (2004, May). Alberta's Meningococcal Immunization Program: A full report. health.alberta.ca/documents/Meningococcal-Campaign-2001.pdf

3 AHS (former Calgary Health Region), Communicable Disease Control. (2005, November). Dates when new programs, vaccines, etc. adopted by Calgary Health Region.

4 AHS (former Capital Health Region), Public Health Division, Communicable Disease Control. (2002, December). Biologicals introduced in Alberta. In Communicable Disease Control Manual (Appendix 4).

5 Waters, John. (1996). Biologicals introduced in Alberta. Unpublished personal file.

? 2007?2016 Government of Alberta

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