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Measurement of TSH is the principal test for the evaluation of thyroid function in the vast majority of circumstances5 . provided. the hypothalamic-pituitary axis is intact. Hypothalamic and pituitary disease can cause central hypothyroidism, which is rare.6,7. A TSH value within the reference interval excludes the majority of cases of primary overt thyroid disease. 3. The TSH reference ... ................
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