National PBM Monograph Template Rev20091005



National Drug Monograph

Prasugrel (Effient™)

April 2010

VA Pharmacy Benefits Management Services,

Medical Advisory Panel, and VISN Pharmacist Executives

The purpose of VA PBM Services drug monographs is to provide a comprehensive drug review for making formulary decisions. These documents will be updated when new clinical data warrant additional formulary discussion. Documents will be placed in the Archive section when the information is deemed to be no longer current.

Executive Summary:

▪ Prasugrel is a thienopyridine agent that inhibits platelet activation and aggregation irreversibly for the life of the platelet, similar to clopidogrel. Prasugrel is approved for the reduction of thrombotic cardiovascular (CV) events including stent thrombosis in patients with acute coronary syndromes (ACS) managed with percutaneous coronary intervention (PCI).

▪ Like clopidogrel, prasugrel is a pro-drug that requires activation to produce its pharmacologic effect. In contrast to the activation of clopidogrel, conversion to the active metabolite with prasugrel occurs quickly and is more efficient. Prasugrel exhibits more rapid, profound and consistent anti-platelet activity compared to clopidogrel with less inter-subject variability in response. Following a loading dose of 60 mg of prasugrel or 600 mg of clopidogrel, significant differences in inhibition of platelet aggregation (IPA) with 20 umol/L ADP were noted at 30 minutes (31% vs. 5%; p ................
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