Top 200 Generic Drugs by Retail Dollars in 2006

[Pages:1]1 Hydrocodone/

Acetaminophen

O O

NH N O

H

O

OH

2 Simvastatin

HO O

O H

O O

3 Azithromycin

N

HO

HO

O

O

OH O

N

O

OH

O

O O

OH

4 Oxycodone

O

O

N

O

OH

5 Gabapentin

H2N

CO2H

6 Amoxicillin/Pot Clav 7

HO

NH2 O

HN H

SN

O

NH

HO2C

O

O

OH CO2H

Fexofenadine

HO2C OH

N

OH

8

Fentanyl

Transdermal

O

N

N

9

Lisinopril

H2N

10 Sertraline

HO2C

N

Cl

NH

N H

O

CO2H

Cl

11 Metformin

NH NH

N

N H

NH2

12 Omeprazole

13 Clopidogrel

N

N

O

S

O

ON

H

OO Cl

N S

14 Paroxetine

F O O

O N H

15 Fluticasone Nasal

F

S HO

H

O O

O

FH O

F

16 Amoxicillin

H2N O O

HN

N

HS HO

CO2H

17 Albuterol Aerosol

HO NH

HO OH

18 Oxycodone w/

Acetaminophen

O

O

NH

O

N

O

OH

OH

19 Levothyroxine 20

I

O

I

NH2

HO2C

I

OH

I

Lovastatin

HO O

OH

O O

2005 Rank: 1

Brand Name: Vicodin Lortab

2006 Sales: $1,623 Million

Profile: A narcotic and analgesic combination used to relieve severe pain.

2005 Rank: Brand Name: 2006 Sales:

N/A

Zocor

$1,390 Million

Profile: An HMG-CoA reductase inhibitor used to lower LDL cholesterol levels.

2005 Rank: Brand Name: 2006 Sales:

62

Zithromax $1,217 Million

Profile: A macrolide antibiotic used to treat mild to moderate bacterial infections.

2005 Rank: Brand Name: 2006 Sales:

5

OxyContin $1,180 Million

Profile: An opioid analgesic used to treat moderate to severe pain.

2005 Rank: Brand Name: 2006 Sales:

2

Neurontin

$1,005 Million

Profile: An anticonvulsant medication used to treat epilepsy and neuropathic pain.

2005 Rank: Brand Name: 2006 Sales:

3

Augmentin $926.0 Million

Profile: An antibiotic and a lactamase inhibitor used to treat bacterial infections.

2005 Rank: Brand Name: 2006 Sales:

41

Allegra

$905.4 Million

Profile: An antihistamine used to treat seasonal allergies.

2005 Rank: Brand Name: 2006 Sales:

9

Duragesic $840.2 Million

Profile: An opioid analgesic used to manage chronic pain.

2005 Rank: 6

Brand Name: Prinivil Zestril

2006 Sales: $727.3 Million

Profile: An ACE inhibitor used to treat hypertension.

2005 Rank: Brand Name: 2006 Sales:

N/A

Zoloft

$700.0 Million

Profile: A selective serotonin reuptake inhibitor used to treat depression and OCD.

2005 Rank: Brand Name: 2006 Sales:

7

Glucophage $670.2 Million

Profile: An anti-hyperglycemic used to treat type 2 diabetes.

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

8

Prilosec

$642.2 Million

N/A

Plavix

$634.6 Million

Profile:

Profile:

A proton pump inhibitor used to treat ulcers and A platelet aggregation inhibitor used to reduce

heartburn.

stroke and heart attack risk.

2005 Rank: Brand Name: 2006 Sales:

4

Paxil

$621.8 Million

Profile: A serotonin reuptake inhibitor used to treat depression and panic disorders.

2005 Rank: Brand Name: 2006 Sales:

N/A

Flonase

$616.2 Million

Profile: A corticosteroid used to treat allergic and nonallergic nasal symptoms.

2005 Rank: Brand Name: 2006 Sales:

10

Amoxil

$492.9 Million

Profile: An antibiotic used to treat bacterial infections.

2005 Rank: 13

Brand Name: Proventil Ventolin

2006 Sales: $485.4 Million

Profile: A bronchodilator used to treat bronchospasms.

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

12

Percocet

$483.6 Million

15

Levoxyl

$471.7 Million

Profile: A narcotic and an analgesic/antipyretic used to treat moderate pain.

Profile: A thyroid hormone used to treat hypothyroidism and to suppress goiters.

2005 Rank: Brand Name: 2006 Sales:

14

Mevacor

$457.3 Million

Profile: An HMG-CoA reductase inhibitor used to lower LDL cholesterol levels.

21 Fluoxetine

22 Pravastatin

23 Alprazolam

24 NovoLog

25 Lorazepam

26 Warfarin

27

Atenolol

28 Tramadol

29 Bupropion SR 30 Hydrochlorothiazide 31 Cephalexin

32 Morphine Sulfate 33 Clonazepam

Non Inj

34 Propoxyphene-N/ 35 Lisinopril/

36 Prednisone Oral 37

Acetaminophen

Hydrochlorothiazide

Quinapril

38 Diltiazem CD

39 Cyclobenzaprine 40 Potassium Chloride

2005 Rank: 11

F3C

O HN

Brand Name: 2006 Sales:

Prozac

$439.8 Million

HO2C HO

O

OH

HO

2005 Rank: Brand Name:

N/A

Pravachol

OH

2006 Sales: $429.2 Million

2005 Rank: 18

Cl

NN

N

N

Brand Name: 2006 Sales:

Xanax

$426.5 Million

2005 Rank: 25

Brand Name: NovoLog

2006 Sales: $399.9 Million

H

Cl

N

N Cl

2005 Rank: Brand Name:

16

Ativan

O OH

2006 Sales: $363.6 Million

2005 Rank: 20

OO

OH O

Brand Name: 2006 Sales: Coumadin $341.0 Million

O NH2

OH

O

NH

2005 Rank: Brand Name: 2006 Sales:

17

Tenormin $327.5 Million

2005 Rank: 23

OH

N O

Brand Name: 2006 Sales:

Ultram

$313.0 Million

2005 Rank: 22

O NH

Brand Name: Wellbutrin SR

Cl

2006 Sales: $305.1 Million

Cl

O S

H2N O

H N

S NH OO

2005 Rank: 21

Brand Name: Microzide Oretic

2006 Sales: $303.1 Million

O

CO2H

O

N

N NH2 H H S

HO

2005 Rank: Brand Name: 2006 Sales: 2005 Rank:

19

Keflex

$301.7 Million

27

N H

O

OH

Brand Name: 2006 Sales:

Kadian

$272.6 Million

Cl N ON H

NO2

2005 Rank: Brand Name: 2006 Sales:

37

Klonopin

$268.0 Million

N OO

2005 Rank: Brand Name:

26

Darvocet

O NH

OH

2006 Sales: $260.3 Million

CO2H NH

O

HO2C N

NH O HN S

O O Cl S O NH2

NH2

2005 Rank: 39

Brand Name: Prinzide Zestoretic

2006 Sales: $248.5 Million

O

2005 Rank: 45

O O

H HH

Brand Name: Deltasone Orasone

OH OH

2006 Sales: $238.9 Million

O O HO2C N

N HO

2005 Rank: Brand Name: 2006 Sales:

31

Accupril

$238.5 Million

O

OO

N

N

S

2005 Rank: Brand Name:

33

Cardizem CD

O

2006 Sales: $234.8 Million

2005 Rank: 46

N

Brand Name: 2006 Sales:

Flexeril

$229.2 Million

2005 Rank: 29

Brand Name: KlorCon

2006 Sales: $227.2 Million

Profile: A selective serotonin reuptake inhibitor used to treat depression and OCD.

Profile: An HMG-CoA reductase inhibitor used to lower LDL cholesterol levels.

Profile: A benzodiazepine used to treat anxiety and panic disorders.

Profile: An insulin analog used to treat diabetes.

Profile: A benzodiazepine used to treat anxiety.

Profile: An anticoagulant used to treat and prevent blood clots.

Profile: A beta-blocker used to treat angina and hypertension.

Profile: An analgesic used to treat moderate to severe pain.

Profile: A norepinephrine and dopamine reuptake inhibitor used to treat depression.

Profile: A thiazide diuretic used to treat excess fluid buildup in the body.

Profile: A cephalosporin antibiotic used to treat bacterial infections.

Profile: A opioid analgesic used to treat moderate to severe pain.

Profile: A benzodiazepine used to treat seizures and panic disorders.

Profile: A narcotic and analgesic combination used to relieve moderate pain.

Profile: An ACE inhibitor and diuretic combination used to treat hypertension.

Profile: A corticosteroid used to treat allergies and asthma.

Profile:

Profile:

An ACE inhibitor used to treat hypertension and A calcium-channel blocker used to treat

heart faillure.

hypertension and angina.

Profile: A muscle relaxant used to treat muscle spasms.

Profile: Potassium chloride used as potassium supplementation.

41 Nabumetone

O O

42 Furosemide Oral

O

H2N S O Cl

CO2H NH O

43 Ciprofloxacin HCl

F

N HN

O CO2H

N

44 Glyburide/

Metformin HCl

O Cl

OH

O

SN O O HN

N H

H N N NH2

NH NH

45 Citalopram HBr

F

N

CN

O

46 Minocycline

47 Carisoprodol

OH O HO OHO

N

H HN

O NH2

OH

HN O

O

NH2

O

O

48 Nifedipine ER

O

O

NH

NO2 O O

49 Tramadol HCl/ 50 Clindamycin

Acetaminophen

Systemic

51 Triamterene w/ 52 Metoprolol Tartrate 53 Amphetamine

Hydrochlorothiazide

Salt Cmb

OH

N O

O NH

OH

N

H

N

O

S

O

OH

OH Cl OH

NH2 N

N

H2N N N NH2 H

Cl

N

O S

H2N O

NH S OO

O

O

NH

OH

OH

HO2C

CO2H OH

NH2

54 Enalapril

55 Verapamil SR

O O

OO

O

N

N

HO

CO2H

NC

N

O

56 Ibuprofen

HO2C

57 Cartia XT

58 Glipizide ER

O

OO

N

N

O

S

H N

H N

O S

OO

O

N

N

H

N

59 Acetaminophen w/

Codeine

OH O

N H

O

N O

H HO

60 Metformin HCl ER

H N N NH2

NH NH

2005 Rank: 32

Brand Name: Relafen

2006 Sales: $223.9 Million

2005 Rank: 34

Brand Name: Lasix

2006 Sales: $220.4 Million

2005 Rank: 36

Brand Name: Cipro

Proquin

2006 Sales: $219.8 Million

2005 Rank: 24

Brand Name: Glucovance

2006 Sales: $218.7 Million

2005 Rank: 28

Brand Name: Celexa

2006 Sales: $217.2 Million

2005 Rank: 30

Brand Name: Dynacin Minocin

2006 Sales: $210.3 Million

2005 Rank: 42

Brand Name: Soma

Vanadom

2006 Sales: $207.4 Million

2005 Rank: 51

Brand Name: Adalat CC

Procardia XL

2006 Sales: $206.1 Million

2005 Rank: 58

Brand Name: Ultracet

2006 Sales: $206.1 Million

2005 Rank: 38

Brand Name: Cleocin Dalacin C

2006 Sales: $203.9 Million

2005 Rank: 35

Brand Name: Dyazide Maxzide

2006 Sales: $202.3 Million

2005 Rank: 49

Brand Name: Lopressor

2006 Sales: $195.0 Million

2005 Rank: 43

Brand Name: Adderall

2006 Sales: $194.4 Million

2005 Rank: 47

Brand Name: Vasotec

2006 Sales: $192.3 Million

2005 Rank: 44

Brand Name: Isoptin SR Calan SR

2006 Sales: $185.4 Million

2005 Rank: 48

Brand Name: Advil Motrin

2006 Sales: $182.9 Million

2005 Rank: 55

Brand Name: Cartia XT

2006 Sales: $181.2 Million

2005 Rank: 50

Brand Name: Glucotrol XL

2006 Sales: $168.2 Million

2005 Rank: 54

Brand Name: Tylenol w/ Codeine

2006 Sales: $160.3 Million

2005 Rank: 40

Brand Name: Fortamet

2006 Sales: $159.7 Million

Profile:

Profile:

An NSAID used to treat rheumatoid arthritis and A loop diuretic used to treat edema and

osteoarthritis.

hypertension.

Profile: An antibiotic used to treat eye inflammations and ulcers.

Profile: A sulfonylurea and biguanide combination used to treat type 2 diabetes.

Profile: A selective serotonin reuptake inhibitor used to treat depression.

Profile: A tetracycline antibiotic used to treat bacterial infections.

Profile:

Profile:

A muscle relaxant used to treat musculoskeletal A calcium channel blocker used to treat angina

conditions.

and hypertension.

Profile: A narcotic and analgesic combination used to treat moderate to severe pain.

Profile: An antibiotic used to treat bacterial infections.

Profile: A diuretic combination used to treat edema and hypertension.

Profile: A beta blocker used to treat hypertension and angina.

Profile: A central nervous system stimulant used to treat narcolepsy and ADHD.

Profile:

Profile:

An ACE inhibitor used to treat hypertension and A calcium channel blocker used to treat high

heart failure.

blood pressure.

Profile: An NSAID used to relieve pain, inflammation, and reduce fever.

Profile: A calcium channel blocker used to treat hypertension and heart rhythm disorders.

Profile: A sulfonylurea antidiabetic used to treat type 2 diabetes.

Profile: A narcotic and analgesic combination used to treat mild to moderate pain.

Profile: An anti-hyperglycemic used to treat type 2 diabetes.

61 Albuterol

62

Nebulizer Solution

Naproxen

H OH

N

OH

O

OH

CO2H

63 Spironolactone

O

O H

HH

O

S

O

64 Mirtazapine

N N N

65 Fluconazole

NN

F

N

F HO

N NN

66 Diclofenac Sodium 67 Glyburide

68 Ranitidine HCl 69 Hydroxyzine

70 Felodipine ER

Cl H N Cl

CO2H

O

HN

O

HN S

O

O NH

O Cl

O N

H N

NO2

S

NH

Cl

N

N

OH

O

O O

HN

Cl

Cl O

O

71 Trazodone HCl 72 Tizanidine HCl

Cl

N N

N NN

O

N

S

Cl

N

HN N

HN

73 Isosorbide

Mononitrate

HO H O O H O NO2

74 Buspirone HCl 75 Promethazine Tabs 76 Doxycycline

77 Glimepiride

O N O

N NN

N

S N N

OH O OH O OH

HH OH N

O NH2

OH

O

O

NH

N

O S HN O HN

O

78 Gemfibrozil

CO2H O

79 Trimethoprim

Sulfate

O

H2N N NH2

O

N

O

80 Cefprozil

HO HS

HN

N

H2N O O

CO2H

2005 Rank: 59

Brand Name: Proventil Ventolin

2006 Sales: $152.1 Million

Profile: A bronchodilator used to treat bronchospasms.

2005 Rank: 65

Brand Name: Aleve

Naprosyn

2006 Sales: $148.9 Million

Profile: An NSAID used to treat fever and minor aches and pains.

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

63

Aldactone $147.0 Million

52

Remeron

$146.5 Million

Profile: A potassium-sparing diuretic used to treat edema, cirrhosis of the liver, and hypokalemia.

Profile: A tetracyclic antidepressant used to treat severe depression.

2005 Rank: Brand Name: 2006 Sales:

56

Diflucan

$146.0 Million

Profile: A triazole antifungal agent used to treat fungal infections.

2005 Rank: 64

Brand Name: Voltaren

2006 Sales: 2005 Rank:

$143.7 Million

57

Brand Name: DiaBeta Glynase

2006 Sales: $143.4 Million

2005 Rank: 53

Brand Name: Zantac

2006 Sales: $141.8 Million

2005 Rank: 68

Brand Name: Atarax Vistaril

2006 Sales: $141.1 Million

Profile: A NSAID used to treat inflammation and joint pain.

Profile: A sulfonylurea used to treat type 2 diabetes.

Profile:

A histamine H2-receptor antagonist used to treat peptic ulcer disease.

Profile: An antihistamine used to treat anxiety and itching caused by allergies.

2005 Rank: Brand Name: 2006 Sales:

102

Plendil

$135.1 Million

Profile: A calcium channel blocker used to treat

hypertension.

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

67

Desyrel

$134.3 Million

60

Zanaflex

$133.5 Million

Profile: A tetracyclic antidepressant used to treat depression and anxiety disorders.

Profile: A skeletal muscle relaxant used to treat muscle spasticity.

2005 Rank: 61

Brand Name: ISMO Imdur

2006 Sales: $130.6 Million

Profile: A nitrate vasodilator used to treat angina.

2005 Rank: Brand Name: 2006 Sales:

71

BuSpar

$128.4 Million

Profile: An antianxiety agent used to treat anxiety disorders.

2005 Rank: Brand Name: 2006 Sales:

75

Phenergan $127.4 Million

Profile: A phenothiazine antihistamine used to treat allergy symptoms.

2005 Rank: 73

Brand Name: Doryx Adoxa

2006 Sales: $124.9 Million

Profile: A tetracycline antibiotic used to treat bacterial infections.

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

N/A

Amaryl

$122.0 Million

72

Lopid

$121.7 Million

Profile: A sulfonylurea used to treat type 2 diabetes.

Profile: An antihyperlipidemic used to treat high cholesterol levels.

2005 Rank: 69

Brand Name: Proloprim Monotrim

2006 Sales: $121.2 Million

Profile: An antibiotic used to treat urinary tract infections and bronchitis.

2005 Rank: Brand Name: 2006 Sales:

N/A

Cefzil

$120.5 Million

Profile: A cephalosporin antibiotic used to treat bacterial infections.

81 Diazepam

O N

N Cl

2005 Rank: Brand Name: 2006 Sales:

81

Valium

$118.0 Million

Profile: A benzodiazepine used to treat anxiety disorders and muscle spasms.

82 Nifedical XL

O

O

NH

OO NO2

83 Clarithromycin

O HO

HO

O

O O

OH N

O

OO O

O OH

84 Nitrofurantoin

Monohydrate

Macrocrystals

O2N O

O

N N NH O

85 Clozapine

N

N

Cl

N

N H

2005 Rank: 84

Brand Name: Nifedical XL

2006 Sales: $117.5 Million

2005 Rank: 122

Brand Name: Biaxin

2006 Sales: $115.6 Million

2005 Rank: 70

Brand Name: Furadantin

Macrodantin

2006 Sales: $114.7 Million

2005 Rank: 82

Brand Name: Clozaril Fazaclo

2006 Sales: $111.4 Million

Profile: A calcium channel blocker used to treat hypertension and angina.

Profile: A macrolide antibiotic used to treat bacterial infections.

Profile:

Profile:

An antibiotic used to treat urinary tract infections. An antipsychotic used to treat schizophrenia.

86 Clotrimazole/ 87 Phentermine

Betamethasone

88 Phenytoin

Sodium Ext

89 Etodolac

90 Clonidine

N Cl

N

O

O O OO

HO

O

H

FH

NH2

NH OH

ON

H N

CO2H

O

H N

H N

Cl

N Cl

2005 Rank: 74

Brand Name: Lotrisone

2006 Sales: 2005 Rank:

$110.6 Million

85

Brand Name: Adipex Ionamin

2006 Sales: $108.2 Million

2005 Rank: 93

Brand Name: Dilantin

2006 Sales: $107.3 Million

2005 Rank: 78

Brand Name: Lodine

2006 Sales: $107.1 Million

2005 Rank: 79

Brand Name: Catapres

2006 Sales: $104.9 Million

Profile: An antifungal and corticosteroid combination used to treat fungal skin infections.

Profile: An amphetamine used to treat obesity.

Profile: An antiepileptic used to control grand mal seizures and temporal lobe seizures.

Profile: An NSAID used to treat pain associated with arthritis.

Profile: An alpha agonist used to treat hypertension.

91 Methotrexate

92 Cefuroxime Axetil 93 Amitriptyline

NH2 N

H2N

N

N

N

N

HO2C

HN O

CO2H

2005 Rank: 80

Brand Name: Rheumatrex

Trexall

2006 Sales: $101.9 Million

O

O O

H2N O

O

O

OO

N N H

SH

NO O

2005 Rank: Brand Name: 2006 Sales:

66

Ceftin

$100.1 Million

N

2005 Rank: 76

Brand Name: Elavil Endep

2006 Sales: $98.8 Million

Profile: An antimetabolite used to treat cancer and to control psoriasis and rheumatoid arthritis.

Profile: A cephalosporin antibiotic used to treat mild to moderately severe bacterial infections.

Profile: A serotonin and norepinephrine reuptake inhibitor used to treat depression.

94 Methylprednisolone

Tabs

HO

O

HO

OH

H

HH O

95 Carbidopa/

Levodopa

HO

CO2H

HO

HN NH2

HO

CO2H

HO

NH2

96 Hydrocodone/

Ibuprofen

O

N O

H O

HO2C

2005 Rank: Brand Name: 2006 Sales:

86

Medrol

$98.3 Million

Profile: A corticosteroid used to treat severe allergies, arthritis, and asthma.

2005 Rank: 95

Brand Name: Atamet Parcopa

2006 Sales: $98.1 Million

Profile: A medication used to treat muscular conditions associated with Parkinson's disease.

2005 Rank: Brand Name: 2006 Sales:

N/A

Vicoprofen $97.4 Million

Profile: A narcotic and NSAID combination used for short-term pain relief.

97 Benazepril

98 Mupirocin

HO

N

O

N O

CO2H

O O

CO2H

OH

OH O

OH

O

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

83

Lotensin

$97.2 Million

94

Bactroban $95.0 Million

Profile:

Profile:

An ACE inhibitor used to treat hypertension and A topical antibiotic used to treat bacterial skin

heart failure.

infections.

99 Finasteride

OH N

H HH ON HH

2005 Rank: Brand Name: 2006 Sales:

N/A

Proscar

$94.2 Million

Profile: An antiandrogen used to treat enlarged prostates.

100 Vancocin HCl

HO NH2

O OH O

HO HO O

Cl

O

Cl

O

O

HO

OH

O

OH

N

N

OH

N

N

OH

N

N

HN H

O

H O

OH

HO2C

NH2

HO

OH OH

2005 Rank: Brand Name: 2006 Sales:

135

Lyphocin

$93.6 Million

Profile: An antibiotic used to treat infections of the intestines.

101 Nystatin Systemic 102 Meloxicam

OH

OH

O

OH

HO

O OH OH OH

OH O

CO2H

OO

HO

OH

NH2

O

OH

S

OS N O

HN

N

103 Bupropion ER 104 Penicillin VK 105 Baclofen

Cl

HN

O

OO HN

H S

N O

CO2H

H2N

CO2H

Cl

106 Fosinopril Sodium 107 Benzonatate 108 Acyclovir

109 Nifedipine

O CO2H O

O

N

P

OO

NH2

O

N

O

O

9

HO ON

NH

N

N

O

H

O

O

N

OO NO2

110 Clobetasol

111 Allopurinol

Cl HO

H

O

O O

FH O

O

NH

N N

N

H

112 Amiodarone 113 Quinine Sulfate 114 Temazepam

I

O

O N

I O

N HO O

N

Cl

N

OH

N O

115 Hydroxy-

chloroquine

116 Polyethylene

Glycol

Cl H N

N

N OH

HO

O

OH

n

117 Terazosin

118 Cilostazol

119 Doxazosin

120 Tretinoin

O N

O

NH2 N

N

N

O

O

NN N

N

H

NO

O

OO

O

O

N

NN

N

O

H2N

CO2H

2005 Rank: 89

Brand Name: Mycostatin Nilstat

2006 Sales: $93.3 Million

Profile: An antifungal used to treat infections of the stomach, intestines, and mucous membranes.

2005 Rank: Brand Name: 2006 Sales:

N/A

Mobic

$92.5 Million

Profile: An NSAID used to treat rheumatoid, osteo-, and juvenile arthritis.

2005 Rank: Brand Name: 2006 Sales:

103

Wellbutrin SR $91.6 Million

Profile: A norepinephrine and dopamine reuptake inhibitor used to treat depression.

2005 Rank: 90

Brand Name: Penicillin-VK

Veetids

2006 Sales: $89.2 Million

Profile: A beta lactam antibiotic used to treat bacterial infections.

2005 Rank: 88

Brand Name: Lioresal Kemstro

2006 Sales: $87.5 Million

Profile: A muscle relaxant and antispastic agent used to treat symptoms of multiple sclerosis.

2005 Rank: Brand Name: 2006 Sales:

77

Monopril

$85.9 Million

Profile: An ACE inhibitor used to treat hypertension.

2005 Rank: Brand Name: 2006 Sales:

91

Tessalon Perles $85.6 Million

Profile: A local anesthetic used to relieve cough.

2005 Rank: Brand Name: 2006 Sales:

97

Zovirax

$85.6 Million

Profile: An antiviral used to treat infections caused by herpes viruses.

2005 Rank: 101

Brand Name: Procardia Adalat

2006 Sales: $84.7 Million

Profile: A calcium channel blocker used to treat angina and hypertension.

2005 Rank: 100

Brand Name: Temovate Clobex

2006 Sales: $84.6 Million

Profile: A topical glucocorticoid used to treat eczema and psoriasis.

2005 Rank: Brand Name: 2006 Sales:

99

Zyloprim

$84.5 Million

Profile: A xanthine oxidase inhibitor used to treat gout, kidney stones, and high levels of uric acid.

2005 Rank: 98

Brand Name: Cordarone Pacerone

2006 Sales: $82.7 Million

Profile: An antiarrhythmic used to treat recurrent heart rhythm disturbances.

2005 Rank: Brand Name: 2006 Sales:

106

Quinine S04 $80.4 Million

Profile: A cinchona alkaloid used to treat malaria.

2005 Rank: Brand Name: 2006 Sales:

109

Restoril

$79.3 Million

Profile: A benzodiazepine used to treat insomnia.

2005 Rank: Brand Name: 2006 Sales:

107

Plaquenil

$76.8 Million

2005 Rank: 185

Brand Name: MiraLax GlycoLax

2006 Sales: $75.7 Million

2005 Rank: Brand Name: 2006 Sales:

105

Hytrin

$75.1 Million

Profile: An aminoquinolone used to treat malaria, lupus erythematosus, and rheumatoid arthritis.

Profile: A laxative used to treat constipation or irregular bowel movements.

Profile: An alpha-adrenergic blocker used to treat hypertension and prostate enlargement.

2005 Rank: Brand Name: 2006 Sales:

96

Pletal

$75.0 Million

Profile: A phosphodiesterase type 3 inhibitor used to treat symptoms of intermittent claudication.

2005 Rank: Brand Name: 2006 Sales:

110

Cardura

$74.5 Million

Profile: An alpha-adrenergic blocker used to treat hypertension and prostate enlargement.

2005 Rank: 117

Brand Name: Vesanoid Retin-A

2006 Sales: $73.4 Million

Profile: A retinoid used to treat acne and acute promyelocytic leukemia.

121 Ketoconazole

Topical

Cl

N N

O O Cl

O

NN

O

2005 Rank: Brand Name: 2006 Sales:

113

Nizoral

$73.1 Million

Profile: An azole used to treat fungal infections of the skin.

122 Butalbital/

Acetaminophen/

Caffeine

O

HO

HN O

NH OO HN

N

N

NH

NO

O

2005 Rank: Brand Name: 2006 Sales:

112

Fioricet

$72.5 Million

Profile: A barbiturate, analgesic, and stimulant combination used to treat tension headaches.

123 Bisoprolol/

Hydrochlorothiazide

NH O

HN

HN S

O

O HO O

O

O Cl S

O NH2

2005 Rank: Brand Name: 2006 Sales:

108

Ziac

$72.3 Million

Profile: A beta blocker and diuretic combination used to treat hypertension.

124 Desmopressin

Acetate

125 Lithium

Carbonate

O

S

Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2

Li2CO3

2005 Rank: 198

Brand Name: DDAVP Stimate

2006 Sales: $71.2 Million

Profile: An antidiuretic hormone used to control frequent urination associated with diabetes.

2005 Rank: Brand Name: 2006 Sales:

119

Eskalith

$69.4 Million

Profile: A mineral used to treat bipolar mania.

126 Megestrol Oral

Suspension

O

O

H

O

HH O

127 Clindamycin

Topical

S OH

O

OH

N

H N

OH

O

Cl

2005 Rank: Brand Name: 2006 Sales:

149

Megace

$68.8 Million

2005 Rank: Brand Name: 2006 Sales:

111

Cleocin T $68.4 Million

Profile: A hormone used to treat anorexia and weight loss in AIDS patients.

Profile: An antibiotic used to treat bacterial infections such as acne.

128 Itraconazole 129 Tamoxifen

Cl

Cl O O

O

NN N

NN

N NN O

N O

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

144

Sporanox

$67.5 Million

87

Nolvadex $67.3 Million

Profile: A triazole used to treat fungal infections.

Profile: An antiestrogen used to treat breast cancer.

130 Nitroglycerin

O2N O

NO2 O

O NO2

2005 Rank: 114

Brand Name: Nitrodur Nitrostat

2006 Sales: $66.8 Million

Profile: A nitrate used to treat or prevent angina.

131 Sotalol

132 Nitrofurantoin

Macrocrystals

HN HO

NH O OS

O2N O

O NN

NH O

2005 Rank: Brand Name: 2006 Sales: 2005 Rank: Brand Name: 2006 Sales:

104

Betapace

$66.6 Million

121

Macrobid

$65.6 Million

Profile: A beta blocker used to treat ventricular arrhythmias.

Profile: An antibacterial agent used to treat and prevent urinary tract infections.

133 Labetalol

134 Folic Acid

O NH2 OH

N H OH

HN NN

CO2H

HN

O

CO2H

O

N

HN

NH2

2005 Rank: 118

Brand Name: Trandate

Normodyne

2006 Sales: $64.8 Million

Profile: An alpha and beta blocker used to treat hypertension.

2005 Rank: Brand Name: 2006 Sales:

123

Folvite

$64.4 Million

Profile: A vitamin used to treat folic acid deficiency, including megaloblastic anemia.

135 Mometasone

Topical

Cl

O

HO

O

O

H

O

Cl H O

2005 Rank: Brand Name: 2006 Sales:

133

Elocon

$63.3 Million

Profile: A topical steroid used to treat allergic reactions, eczema, and psoriasis.

136 Triamcinolone

Acetonide Top

OH

O

HO

O

H

O

FH O

137 Torsemide

O S

H N

H N

N

OO

NH

138 Metoclopramide

H

N

NO

O

Cl NH2

2005 Rank: 127

Brand Name: Kenalog Triderm

2006 Sales: $62.8 Million

Profile: A topical steroid used to treat allergic reactions, eczema, and psoriasis.

2005 Rank: Brand Name: 2006 Sales:

116

Demadex

$62.8 Million

Profile: A loop diuretic used to treat hypertension and edema.

2005 Rank: Brand Name: 2006 Sales:

124

Reglan

$60.9 Million

Profile: A gastrointestinal stimulant used to treat diabetic gastric stasis and gastric reflux.

139 Prednisolone Sd

Phosphate Oral

HO O P

O OH O

HO

OH

H

O

2005 Rank: 140

H

Brand Name: Orapred PediaPred

2006 Sales: $59.4 Million

Profile: A corticosteroid used to treat allergies, arthritis, and asthma.

140 Zonisamide

ON

O S NH2 O

2005 Rank: Brand Name: 2006 Sales:

N/A

Zonegran

$59.1 Million

Profile: An anticonvulsant used to treat partial seizures in adults with epilepsy.

141 Glipizide

142

H N

H N

O

S

OO

N NH

N

O

N

Diltiazem

O

OO

N

O

S

143 Azathioprine

NO2

N

S N

H N

N

N

N

144 Medroxyprogest- 145

erone Injection

O

O

H

O

HH O

Hydralazine

H2N NH N N

146 Estradiol Oral

OH H HH HO

147 Ribavirin

HO

N

ON

N

HO OH

NH2 O

148 Fluvoxamine 149 Mercaptopurine

H2N

O ON CF3

S

H

HN

N

NN

150 Metronidazole

Tabs

O2N

OH N

N

151 Famotidine

152 Cefadroxil

153 Diltiazem SR

O

H2N

HO

NO S S

O NH2

S NH2 N N NH2

HS

HN

N

CO2H

OO

N

N

S

O

H2N O O

154 Carbidopa/

Levodopa ER

HO

CO2H

HO

HN NH2

HO

CO2H

HO

NH2

155 Methadone HCl

Non-Injection

O NH

156 Methylphenidate 157 Oxandrin

OO H N

OH

O O

H HH H

158 Ursodiol

159 Methocarbamol 160 Metolazone

H

HH

HO

H

OH

CO2H

H2N O

O

O

O

OH

H2N

O S

O

Cl

O N

N H

2005 Rank: Brand Name: 2006 Sales:

137

Glucotrol

$59.1 Million

Profile: A sulfonylurea used to treat type 2 diabetes.

2005 Rank: Brand Name: 2006 Sales:

139

Cardizem

$59.0 Million

Profile: A calcium channel blocker used to treat hypertension, angina, and arrhythmias.

2005 Rank: 125

Brand Name: Azasan Imuran

2006 Sales: $58.9 Million

Profile: An antimetabolite used to prevent kidney transplant rejection.

2005 Rank: Brand Name: 2006 Sales:

161

Depo-Provera $58.3 Million

Profile: A progestin hormone used as birth control.

2005 Rank: Brand Name: 2006 Sales:

157

Apresoline $58.2 Million

Profile: A vasodilator used to treat hypertension.

2005 Rank: 126

Brand Name: Activella Estrace

2006 Sales: $57.5 Million

Profile: An estrogen used to treat symptoms associated with menopause.

2005 Rank: N/A

Brand Name: Copegus Rebetol

2006 Sales: $56.5 Million

Profile: An antiviral medicine used to treat hepatitis C infection.

2005 Rank: Brand Name: 2006 Sales:

115

Luvox

$55.0 Million

Profile: A selective serotonin reuptake inhibitor used to treat OCD.

2005 Rank: Brand Name: 2006 Sales:

132

Purinethol $54.8 Million

2005 Rank: Brand Name: 2006 Sales:

129

Flagyl

$54.4 Million

Profile: An antimetabolite used to treat acute lymphatic leukemia.

Profile: An antiprotozoal and antibacterial agent used to treat infection.

2005 Rank: Brand Name: 2006 Sales:

130

Pepcid

$54.3 Million

Profile: A histamine blocker used to treat ulcers and heartburn.

2005 Rank: Brand Name: 2006 Sales:

147

Duricef

$54.0 Million

Profile: A cephalosporin antibiotic used to treat bacterial infections.

2005 Rank: 136

Brand Name: Cardizem Tiazac

2006 Sales: $53.0 Million

Profile: A calcum channel blocker used to treat high blood pressure and chest pain.

2005 Rank: Brand Name: 2006 Sales:

120

Sinemet CR $52.6 Million

Profile: A medication used to treat muscular conditions associated with Parkinson's disease.

2005 Rank: 196

Brand Name: 2006 Sales: Methadose $52.1 Million

Dolophine HCl

Profile: A narcotic used to relieve pain during drug addiction detoxification programs.

2005 Rank: Brand Name: 2006 Sales:

138

Ritalin

$52.0 Million

Profile: A central nervous system stimulant used to treat ADHD and narcolepsy.

2005 Rank: Brand Name: 2006 Sales:

148

Oxandrin

$51.5 Million

Profile: An anabolic steroid used to promote weight gain and to relieve pain due to osteoporosis.

2005 Rank: 128

Brand Name: Urso

Actigall

2006 Sales: $51.0 Million

Profile: A bile acid used to dissolve small gallstones and to treat primary biliary cirrhosis.

2005 Rank: Brand Name: 2006 Sales:

145

Robaxin

$50.1 Million

Profile: A muscle relaxant used to treat injuries and other painful muscular conditions.

2005 Rank: 143

Brand Name: Mykrox

Zaroxolyn

2006 Sales: $49.3 Million

Profile: A quinazoline diuretic used to treat hypertension.

161 Promethazine/

Codeine

O

SN

NO

N

H HO

162 Calcitriol

HO OH

HO

2005 Rank: 141

Brand Name: Phenergan with Codeine

2006 Sales: $48.4 Million

Profile: A narcotic and antihistamine combination used to treat upper respiratory symptoms.

2005 Rank: Brand Name: 2006 Sales:

163

Rocaltrol

$47.0 Million

Profile: A synthetic form of vitamin D used to treat osteoporosis and low blood calcium levels.

163 Hydromorphone

HCl

N

HO

O

O

2005 Rank: Brand Name: 2006 Sales:

173

Dilaudid

$46.7 Million

Profile: A opioid analgesic used to relieve moderate to severe pain.

164 Ipratropium Br

Nebulizer Solution

N OH

O

O

2005 Rank: Brand Name: 2006 Sales:

134

Atrovent

$45.6 Million

Profile: An anticholinergic used to treat obstructive lung diseases.

165 Clorazepate

Dipot

HO N

CO2H

Cl

N

2005 Rank: Brand Name: 2006 Sales:

142

Tranxene

$45.5 Million

Profile: A benzodiazepine used to treat anxiety disorders, alcohol withdrawal, and epilepsy.

166 Leflunomide

O

O

F3C

NH

N

2005 Rank: Brand Name: 2006 Sales:

N/A

Arava

$45.2 Million

Profile: A pyrimidine synthesis inhibitor used to reduce symptoms of rheumatoid arthritis.

167 Indomethacin SR

O Cl

N O

CO2H

2005 Rank: Brand Name: 2006 Sales:

N/A

Indocin SR $45.1 Million

Profile: An NSAID used to treat rheumatoid arthritis and osteoarthritis.

168 Terconazole

N

Cl

N N

O

O

O

Cl N

N

2005 Rank: Brand Name: 2006 Sales:

153

Terazol

$45.0 Million

Profile: An antifungal agent used to treat vaginal fungal infections.

169 Erythromycin/

Benzoyl Peroxide

O

HO

O

O

OHO O

O

OH HO

N

O OH

O

O

O O

O

2005 Rank: Brand Name: 2006 Sales:

131

Benzamycin $44.8 Million

Profile: An antibiotic and antibacterial combination used to treat acne.

170 Propranolol HCl

O

N

OH H

2005 Rank: Brand Name: 2006 Sales:

151

Inderal

$44.7 Million

Profile: A beta blocker used to treat hypertension and to prevent angina.

171 Flecainide

Acetate

CF3 O

O

HN

NH

CF3

O

2005 Rank: Brand Name: 2006 Sales:

160

Tambocor $42.9 Million

Profile: An antiarrhythmic used to treat heart rhythm disturbances.

172 Clarithromycin

ER

O HO

HO

O

O O

OH N

O

OO O

O OH

2005 Rank: Brand Name: 2006 Sales:

N/A

Biaxin XL $41.8 Million

Profile: A macrolide antibiotic used to treat bacterial infections.

173 Dexamphetamine

Sulfate

NH2

2005 Rank: 165

Brand Name: Dexedrine DextroStat

2006 Sales: $41.5 Million

Profile: A central nervous system stimulant used to treat ADHD and narcolepsy.

174 Propafenone

O

O

N

OH H

2005 Rank: Brand Name: 2006 Sales:

155

Rythmol

$41.4 Million

Profile: A antiarrhythmic used to treat irregular heartbeats.

175 Carbamazepine

O NH2 N

2005 Rank: 159

Brand Name: Tegretol Carbatrol

2006 Sales: $40.8 Million

Profile: An anticonvulsant used to treat seizures and bipolar disorder.

176 Hyoscyamine

N

O O OH

177 Timolol Maleate

GFS

O N

HO H N

O

NS N

2005 Rank: 152

Brand Name: Levsin

Anaspaz

2006 Sales: $40.5 Million

2005 Rank: Brand Name: 2006 Sales:

150

Timoptic

$40.5 Million

Profile: An anticholinergic agent used to treat stomach, intestinal, and bladder conditions.

Profile: A beta blocker used to treat open-angle and secondary glaucoma.

178 Fluocinonide

O

O HO

H

O O

O

FH O

F

2005 Rank: 158

Brand Name: Lidex Vanos

2006 Sales: $40.2 Million

Profile: A topical steroid used to treat inflammation and itching due to eczema and psoriasis.

179 Cabergoline

H ON

ON

N

H N H

HN

2005 Rank: Brand Name: 2006 Sales:

N/A

Dostinex

$40.1 Million

Profile: A dopamine receptor agonist used to treat hyperprolactinemia.

180 Desoximetasone

OH O

HO H

FH O

2005 Rank: Brand Name: 2006 Sales:

172

Topicort

$40.0 Million

Profile: A topical corticosteroid used to relieve inflammation and itching of the skin.

181 Microgestin

Fe 1/20

OH O H

O HH

HO

HH

HH O

2005 Rank: Brand Name:

156

Microgestin

Fe 1/20

2006 Sales: $39.2 Million

Profile: A progestin and estrogen combination used to prevent pregnancy and regulate menstration.

182 Nicotine

Transdermal

N N

2005 Rank: 191

Brand Name: Habitrol Nicoderm

2006 Sales: $38.8 Million

Profile: A smoking deterrent used to reduce nicotine withdrawal symptoms.

183 Primidone

H NO HN O

2005 Rank: Brand Name: 2006 Sales:

182

Mysoline

$38.6 Million

Profile: An anticonvulsant used to treat seizures.

184 Didanosine

HO

O

N N

O

N NH

2005 Rank: Brand Name: 2006 Sales:

174

Videx

$38.3 Million

Profile: A reverse transcriptase inhibitor used to treat HIV infection.

185 Cyclosporine

OH

N

O

MeLeu-MeVal

Abu-MeGly

Me-Leu-D-Ala-Ala-MeLeu-Val-MeGlu

2005 Rank: N/A

Brand Name: Restasis

Sandimmune

2006 Sales: $38.1 Million

Profile: An immunomodulator used to treat chronic dry eyes and to prevent organ rejection.

186 Imipramine HCl

N N

2005 Rank: 162

Brand Name: Tofranil Impril

2006 Sales: $37.8 Million

Profile: An antidepressant used to treat depression, chronic pain, and bulimia nervosa.

187 Nadolol

OH

OH O

H N HO

2005 Rank: Brand Name: 2006 Sales:

177

Corgard

$37.6 Million

Profile: A beta-blocker used to treat angina and hypertension.

188 Evoclin

NH N

O

S

O

OH

OH OH Cl

2005 Rank: Brand Name: 2006 Sales:

N/A

Evoclin

$37.4 Million

Profile: An antibiotic used to treat acne.

189 Midodrine HCl

HO

O

HN

O

O

NH2

2005 Rank: Brand Name: 2006 Sales:

183

ProAmatine $37.4 Million

Profile: A vasopressor/antihypotensive used to treat orthostatic hypotension.

190 Naproxen

Sodium

CO2H O

2005 Rank: 170

Brand Name: Anaprox Aleve

2006 Sales: $37.2 Million

Profile: An NSAID used to relieve pain.

191 Butorphanol NS

N OH

HO

2005 Rank: Brand Name: 2006 Sales:

164

Stadol NS $36.9 Million

Profile: An opioid analgesic used to treat moderate to severe pain.

192 Oxybutynin

Chloride

O

O

OH

N

2005 Rank: Brand Name: 2006 Sales:

N/A

Ditropan

$36.7 Million

Profile: An anticholinergic medication used to treat overactive bladder.

193 Ciclopirox

OH NO

2005 Rank: 180

Brand Name: Loprox Penlac

2006 Sales: $36.6 Million

Profile: An antifungal agent used to treat infections of the skin, toenails, and fingernails.

194 PhosLo

Ca(OAc)2

2005 Rank: Brand Name: 2006 Sales:

N/A

PhosLo

$36.3 Million

Profile: A mineral used to reduce phosphate levels in late-stage kidney failure.

195 Atenolol

Chlorthalidone

O NH2

O Cl

NH OH

O

S

H2N O

HO

N H

O

2005 Rank: Brand Name: 2006 Sales:

178

Tenoretic

$36.3 Million

Profile: A beta blocker and diuretic combination used to treat hypertension.

196 Meclizine HCl

N

Cl

N

2005 Rank: 171

Brand Name: Antivert Bonine

2006 Sales: $36.2 Million

Profile: An antihistamine used to relieve nausea, and dizziness associated with motion sickness.

197 Griseofulvin

O OO

O

O

O

Cl

2005 Rank: N/A

Brand Name: Fulvicin Gris-PEG

2006 Sales: $35.4 Million

Profile: An antifungal medication used to treat infections of the skin, hair, and nails.

198

Econazole Nitrate

N

N

Cl

O

Cl

Cl

2005 Rank: Brand Name: 2006 Sales:

175

Spectazole $34.4 Million

199 Butalbital Cmpd

w/ Codeine

O

N

N

OO

CO2H

ON N

O

H

ONO

O

N

HN O

H HO

2005 Rank: 184

Brand Name: Fiorinal with Codeine

2006 Sales: $34.3 Million

Profile: An antifungal medication used to treat athlete's foot and ringworm.

Profile: A narcotic, muscle relaxant, and analgesic used to treat tension headache

200 Sucralfate

OR O

R = SO3Al(OH)2

OR OR

O

OR OR

OR

O RO

OR

2005 Rank: Brand Name: 2006 Sales:

N/A

Carafate

$33.8 Million

Profile: A gastric protective agent used to treat ulcers.

Reference drugtopics/data/articlestandard/drugtopics/072007/405102/article.pdf

Njardarson Group: Laura Kwon, Erik Rogers, Nicholas McGrath, Matthew Brichacek, J?n T. Njar?arson

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