Opioids > 50 mg Morphine Equivalent Daily Dose (MEDD)

For conversion from transdermal fentanyl, approximately 9 mg every 12 hours should initially be substituted for each 25 µg/hr of fentanyl transdermal patch. Maintenance: Titrate dose to efficacy every 1 to 2 days. The total daily oxycodone dose usually can be increased by 25% to 50% of the current dose each time an increase is clinically ... ................
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