Role of Digoxin in Diastolic Heart Failure
DESIGNING NON-RCT STUDIES LIKE RCT USING PROPENSITY SCORE MATCHING: EVIDENCE FOR DIURETICS, HYPOKALEMIA, AND POTASSIUM SUPPLEMENTS IN CHRONIC HEART FAILURE
A. Ahmed
University of Alabama at Birmingham, Birmingham, AL, USA
The ACC/AHA 2005 chronic heart failure (HF) guideline recommendation for the use of diuretics in is the only Class I pharmacotherapeutic recommendation that is based on Level C evidence. When randomized clinical trials (RCT) are either ethically unjustifiable or logistically unfeasible, non-RCT studies can provide evidence, at least temporarily.
Compared with traditional regression-based multi-variable risk-adjustment models, propensity score matching has three distinct advantages: (1) it allows investigators to design non-RCT studies like RCT so that investigators remain blinded to study outcomes in the design phase of the study; (2) it allows objective estimation of baseline imbalances between treatment or exposure groups and the balances achieved after matching, using absolute standardized differences; and (3) the bedside manner of research: it allows presentation of post-match balance in visually appealing tabular and graphic formats that can be easily appreciated by clinician readers.
Data will be presented from three propensity-matched studies to demonstrate the effect of diuretics, hypokalemia and potassium supplements in chronic HF. Diuretic therapy can lead to neurohormonal activation and electrolyte imbalance, in particular hypokalemia. Yet the long-term effects of diuretic therapy and hypokalemia in chronic HF remain unknown. Finally, even though spironolactone, an aldosterone antagonist, may help maintain normokalemia after initial hypokalemia has been corrected, potassium supplements are often used instead to maintain normokalemia. Yet, the long-term effects of potassium supplements are unknown. Findings from these studies will highlight the procedural transparency and superiority of the propensity score matching, its role in the design of non-RCT studies as in RCT, and its potential to provide evidence when none is available from RCT.
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- purpose this course provides an overview of congestive
- role of digoxin in diastolic heart failure
- needs statement american medical seminars
- phs 398 rev 9 04 continuation page
- side effects low blood pressure dizziness low heart
- heart failure protocol read code g580
- this grid is to illustrate how the clinical content for
- congestive cardiac failure
Related searches
- role of business in economy
- role of business in society
- role of law in society
- role of management in business
- role of management in organization
- role of science in society
- role of teacher in classroom
- role of finance in business
- role of scientist in society
- role of government in economy
- role of education in society
- role of government in free market economy