Helicobacter pylori: Update on disease, Diagnostics, and ...

DEPARTMENT OF PATHOLOGY

Helicobacter pylori: Update on disease, Diagnostics, and Discouraging Trends

Marc Roger Couturier, Ph.D., D(ABMM)

Associate Professor of Pathology ARUP Medical Director: Microbial Immunology

Parasitology & Fecal Testing Infectious Disease Rapid Testing

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Relevant Disclosures

DEPARTMENT OF PATHOLOGY

? Speaking fees ? Meridian Biosciences

? Research funds ? Meridian Biosciences

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Helicobacter pylori

DEPARTMENT OF PATHOLOGY

? Gram negative microaerophile

? Lophotrichous flagella ? Human 1o host

? Gastric pathogen

.au

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DEPARTMENT OF PATHOLOGY

H. pylori Disease Associations

? Established:

? Peptic Ulcer Disease (PUD) ? Dyspepsia ? Non-ulcer dyspepsia (NUD) ? Gastric adenocarcinoma ? MALT lymphoma ? Possible:

? Iron deficiency

? Not associated:

? Gastroesophageal reflux disease (GERD) ? Coronary artery disease (CAD)

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DEPARTMENT OF PATHOLOGY

Disease progression

Peptic ulcer disease

~10%

MALT Lymphoma

1%

None

Mild

Severe

WHO classifies H. pylori as the only bacterial Class 1 Carcinogen

Adapted from: Peek and Blaser, Nature Rev. Cancer, 2002

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