Northwestern Medicine Antimicrobial Stewardship

For UTI’s, usu. in combination with trimethoprim; otitis, bronchitis, sinusitis, P. carinii pneumonia Trimethoprim. Inhibits dihydrofolate reductase (folate synthesis) Similar to sulfonamides, but 20-50X more potent Concentrates in acidic prostate and vaginal fluids ................
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