AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY

In the 1980s he demonstrated that a selective lesion of the nucleus basalis, produced by the injection of glutamate agonists, resulted in cholinergic deficit, similar to that seen in Alzheimer’s disease (AD) and hypothesized that in the pathomechanism of AD, over-activation of N-methyl-D-aspartate (NMDA) receptors by glutamate plays a role. ................
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