Non-Hodgkins lymphoma: B-cell



Non-Hodgkins lymphoma: B-cell

Low grade (well differentiated)

|name |% |age |clinical pres. |progression? |histology |markers |course |prognosis |

|SLL | | |usu. Stage IV – marrow |20-30% |nodes effaced w/ small|CD5+, 23+ |indolent |moderate |

| |4-6 |20+ | |transform to |dark lymphs |CD19+,20+ | |50-60% 5ys |

|Small lymphocytic | | |often asymptomatic |pro-lymphocytic | |low Ig exp. |remission not critical| |

|(CLL) | |90% |lymphad, hepatosplenomeg. |or 10 % DLCL |prolymph proliferation| | |poor w/ transform. or |

| | |>50 |B sx |(Richter synd) |centers |trisomy 12 | |trisomy 12 |

| | | |hypo-Ig’s, anemia | | |del 13q | | |

| | | |some w/ Ig spike, +Coombs | |smudge cells |del 11q | | |

|follicular | | |painless lymphadenopathy |30% to DLCL |nodular |CD5-, 10+ |indolent |good |

| |45 |most |(generalized) | |small, cleaved |CD19+,20+ | |80% 5ys |

| | |40-65 | | |centrocytes | |remission not helpful | |

| | | | | |usu. marrow |t(14;18) |(incurable) |worse w/ higer grade |

| | | | | |involvement |BCL-2 | | |

|marginal zone | | |Peptic ulcer sx. due to H.pylori or |late systemic spread |small irregular lymphs|CD5-, 10-CD23- |indolent |excellent |

|(MALT type) |5 |all |lymphadenopathy/ extranodal in pts w/ | |in marginal zone node | | |90% 5ys |

| | | |chronic inflamm. disorders |some to DLCL | |t(11,18) |tx Abx for H.pylori | |

| | | | | | | |form | |

|mantle-cell | | |generalized lymphadeno. |rare transformat. |diffuse follicle |CD5+, 23- |aggressive |poor |

| |3-6 |40-50 |marrow/liver involvement |(course too rapid?) |effacement, |CD19+,20+ | | ................
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