Estrogen Modulation of Cerebrovascular Inflammation ...
80018
Estrogen Modulation of Cerebrovascular Inflammation: Changes with Increasing Age
Christa Osuna
Mentors: Sue Duckles, Diana Krause & Lorraine Sunday
Menopause is marked by decline in a woman’s production of estrogen; however, it is unclear if this decline contributes to increased chances of stroke. Although this hormone can regulate stroke-associated inflammation in cerebral vessels, it is unknown if it has the same effect with increased age. This study examined the effect(s) of estrogen on pro-inflammatory mechanisms in cerebral vessels: NFκB translocation, induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and production of nitric oxide (NO) and prostaglandin E2 (PGE2). Three-month and 12-month female rats were used. Each age category contained two groups: ovariectomized and ovariectomized with estrogen treatment for four weeks. Vascular inflammation was induced using lipopolysaccharide (LPS), both in vivo and in vitro. DNA binding assays measuring the NF(B subunit p65 indicate that 12-month animals have more nuclear NFκB activity than 3-month animals. The estrogen-treated groups of both ages showed lower levels of NF(B activity than the untreated groups. Western blots indicated that LPS upregulation of iNOS and COX-2 was markedly increased at 12 months compared to three months. Estrogen decreased the levels of inflammatory mediators in 3-month rats, but had less of an effect at 12 months. These results suggest estrogen has significant anti-inflammatory effects in the cerebrovasculature of young, but not in middle-aged, animals where the inflammatory response is greater. Thus estrogen in pre-menopausal women may be protective against stroke, but changes in the blood vessels resulting from age may prevent estrogen from providing its anti-inflammatory effects in the cerebrovasculature of older women.
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- estrogen modulation of cerebrovascular inflammation
- abstract for the national meeting of the society for
- port numbers ludwig nachrichtentechnik
- se promueve diligencia preparatoria de consititucion de
- philosophy 5 contemporary moral problems
- port numbers
- metodika návrhu zpracování
- a curvatura do espaço jurídico
- uci calteach science mathematics program
- definitions university of california irvine
Related searches
- cerebrovascular accident vs cerebral infarct
- pathophysiology of inflammation process
- inflammation of uvula icd 10
- chronic inflammation of lymph nodes
- inflammation of lymph nodes disease
- inflammation of eyelids
- inflammation of eyelid rim
- cerebrovascular disease vs cva
- inflammation of muscles
- inflammation of muscles syndrome
- inflammation of the muscles
- stages of inflammation pdf