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CURRICULUM VITAE

Friedrich Rainer von Coelln, Dr. med.

Assistant Professor, Department of Neurology

University of Maryland School of Medicine

Date June 16, 2016

Contact Information

Business Address: Dept. of Neurology

110 S. Paca St., 3rd floor

Baltimore, MD 21201

Business Phone Number: (410) 328-7809

Fax: (410) 328-0167

Email: rvoncoelln@som.umaryland.edu

Foreign Languages: German (native)

Education

1990 – ‘92 Preclinical studies, Heinrich Heine University Medical School, Duesseldorf, Germany

1992 – ’97 Clinical studies, Ruprecht-Karls University Medical School, Heidelberg, Germany

06/1997 Preliminary license to practice medicine, State Board of Examination for Medicine and Pharmacy of the State of Baden-Wuerttemberg, after graduating from Ruprecht Karls University Medical School, Heidelberg, Germany (equivalent to M.D. degree in the U.S.)

04/1998 Dr. med., Ruprecht Karls University Medical School, Heidelberg, Germany. Thesis: "Interleukins 1-12: Potential neurotrophic effects on mesencephalic dopaminergic neurons." Thesis Advisor: Klaus Unsicker (equivalent to Ph.D. degree in the U.S.)

04/1999 Unrestricted license to practice medicine, State Board of Examination for Medicine and Pharmacy of the State of Baden-Wuerttemberg (based on completion of medical school plus 18 months of practice as resident).

Post Graduate Education and Training

1997 – 2001 Neurology residency (part 1), Dept. of Neurology, University of Tuebingen, Germany

2001 – 2004 Postdoctoral Fellowship in Neurobiology. Mentor: Ted Dawson. Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD

2004 – 2008 Neurology residency (part 2), Dept. of Neurology, University of Tuebingen, Germany

2009 – 2010 Clinical Fellowship in Movement Disorders. Mentors: Joseph Savitt, Zoltan Mari. Dept. of Neurology, Johns Hopkins University, Baltimore, MD

2010 – 2011 Internship, Dept. of Medicine, Harbor Hospital Center, Baltimore, MD.

2011 – 2014 Neurology residency, Dept. of Neurology, University of Maryland, Baltimore, MD.

Certifications

2008 (active) Board-certified Neurologist, District Medical Association Sued-Wuerttemberg, Germany

2014 (active) American Board of Psychiatry and Neurology

Medical Licensure

Active Maryland (D0077727, exp. 9/30/2017)

Active Germany

Military Service

1989 – 1990 Basic military service, 7th paramedic battalion and 7th music corps, German Armed Forces ("Bundeswehr")

Employment History

Academic Appointments

04 – 09/2008 Staff Neurologist, Dept. of Neurology, University of Tuebingen, Germany

10 – 12/2008 Senior Staff Neurologist, Acting Attending Physician, Dept. of Neurology, University of Tuebingen, Germany

07/2014 – Assistant Professor, Dept. of Neurology, University of Maryland School of Medicine, Baltimore, MD.

Professional Society Membership

1998 – 2009 General Member, Society for Neurosciences (SfN)

1998 – 2008 Resident Member, German Society for Neurology (DGN)

2001 – 2008 Resident Member, German Society for Clinical Neurophysiology and Functional Imaging (DGKN)

2008 – International Parkinson and Movement Disorder Society (MDS)

2011 – American Academy of Neurology (AAN)

Honors And Awards

1991 – 1996 German National Merit Foundation ("Studienstiftung des Deutschen Volkes")

2011 Preliminary Medicine Intern of the Year, Harbor Hospital Center, Baltimore, MD

2011 Award for Outstanding Clinical Vignette, Maryland Chapter, American College of Physicians, Chief Residents Association

Clinical Activities

1999 – 2001 Parkinson disease outpatient clinic (incl. co-investigator in several industry-sponsored clinical trials, Dept. of Neurology, Univ. of Tuebingen, Germany

2005 – 2008 Dystonia/Botulinum toxin outpatient clinic, Dept. of Neurology, Univ. of Tuebingen, Germany

2006 – 2007 Geriatric psychiatry inpatient service, Dept. of Psychiatry, Univ. of Tuebingen, Germany

2014 – Movement disorder and dementia outpatient clinic, UMD, Baltimore, MD

2014 – Deep Brain Stimulation outpatient clinic, UMD, Baltimore, MD

2014 – Attending physician for the General Neurology inpatient service, UMD, Baltimore, MD

2014 – Co-Investigator in several industry-sponsored clinical trials

2016 – Local Principal Investigator for industry-sponsored multicenter clinical trial (CVT-301-004)

Clinical Expertise

Board certified neurologist in Germany

Fellowship-trained in Movement Disorders (18 months, Johns Hopkins University)

Clinical and research focus in the area of Parkinson disease and related disorders

Botulinum toxin injections for treatment of dystonia and spasticity incl. face/head, neck, and extremities

Deep brain stimulation programming for Parkinson disease, Essential tremor, dystonia

Institutional Service

2012 –2014 UMMC Graduate Medical Education Commission (GMEC) resident member

2014 – Dept. of Neurology Residency Oversight and Clinical Competency Committee

2014 – Dept. of Neurology Residency Interview Committee

Teaching Service

Medical Student Teaching

1999 – 2001 and 2004 – 2008 Practical Course in Neurological Examination (small groups),

3rd year medical students, 7.5 hours/semester.

2014 – Movement disorders for 3rd year medical students, monthly one hour lecture

2014 – Bedside teaching for 3rd and 4th year medical students in clinic and inpatient service

Resident Teaching

2014 – Yearly movement disorder block lectures (Genetics/pathology; medical management)

2014 – Supervision of resident continuity clinic (9 afternoon sessions per year)

2014 – Bedside teaching of movement disorders and general neurology of rotating residents in clinic and during the inpatient service weeks

Fellow Teaching

2014 – Supervision and discussion of cases in 2x weekly clinic with movement disorder fellow

Grant Support

Active Grants:

07/01/14 – 06/30/16 PI, 80%

“Genetic Determinants of Clinical Heterogeneity in Parkinson Disease”

Clinical Research Training Fellowship, American Academy of Neurology

Annual Direct Costs: $65,000

Total Direct Costs: $130,000

07/01/15 – 06/30/16 PI, 5% (no salary support for PI)

“Towards Refined Phenotyping of Parkinson’s Disease: Quantitative Analysis of Gait and Balance Using a Portable Biosensor Device”

University of Maryland Claude D. Pepper Older Americans Independence Center (UM- OAIC) pilot project.

Annual Direct Costs: $10,000

Total Direct Costs: $10,000

10/01/15 – 09/30/17 Co-PI, percentage not specified (no salary support)

" Use of Visualization Assisted Clustering to Detect Diverse Patterns of Disease Progression in Parkinson’s Disease"

UMD-UMB Innovation Seed Grant

Annual Direct Costs: $50,000

Total Direct Costs: $100,000

Completed Grants:

01/01/07 – 12/31/07 PI, 20% (salary support for Ph.D. student only)

“Identification of serine 129-phosphorylation-specific binding partners of α-synuclein”

fortüne intramural grant, University of Tuebingen (F1313029)

Annual Direct Costs: $98,000

Total Direct Costs: $98,000

10/01/01– 09/30/03 Co-investigator, percentage N/A*; PI: Ted Dawson, Johns Hopkins University

“Generation and characterization of parkin-deficient and A53T-α-synuclein

overexpressing/parkin-deficient mice”

German Research Foundation, postdoctoral fellowship award (CO 286/1-1)

Annual Direct Costs: $21,000

Total Direct Costs: $42,000

*Postdoctoral fellow, award covered 67% salary support.

Publications

Peer-reviewed journal articles

1. von Coelln R., Unsicker K., Krieglstein K. Screening of interleukins for survival-promoting effects on cultured mesencephalic dopaminergic neurons from embryonic rat brain. Dev. Brain Res. 1995; 89:150-154.

2. Schulz J.B., Weller M., Matthews R.T., Heneka M.T., Groscurth P., Martinou J.C., Lommatzsch J., von Coelln R., Wüllner U., Löschmann P.A., Beal M. F., Dichgans J., Klockgether T. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death Diff. 1998;5:847-857. (Ran analyses)

3. Eberhardt O., von Coelln R., Kügler S., Lindenau J., Rathke-Hartlieb S., Gerhardt E., Haid S., Isenmann S., Gravel C., Srinivasan A., Bähr M., Weller M., Dichgans J., Schulz J.B. Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease. J. Neurosci. 2000;20:9126-9134. (Ran analyses)

4. von Coelln R., Kügler S., Bähr M., Weller M., Dichgans J., Schulz J.B. Rescue from death but not from functional impaiment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. J. Neurochem. 2001;77:263-273.

5. von Coelln R., Thomas B., Savitt J. M., Lim K.L., Sasaki M., Hess E.J., Dawson V.L., Dawson T.M. Loss of Locus Coeruleus Neurons and Reduced Startle in Parkin Null Mice. Proc. Natl. Acad. Sci. U.S.A. 2004;101:10744-10749.

6. von Coelln R., Dawson V.L., Dawson T.M. Parkin-associated Parkinson's disease. (Review). Cell Tissue Res. 2004;318:175-184.

7. Ko HS., von Coelln R., Sriram S.R., Kim S.W., Chung K.K., Pletnikova O., Troncoso J., Johnson B., Saffary R., Goh E.L., Song H., Park B.J., Kim M.J., Kim S., Dawson V.L., Dawson T.M. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neurosci. 2005;25:7968-7978. (Dissected animals, prepared samples).

8. von Coelln R.*, Thomas B.*, Andrabi S.A., Lim K.L., Savitt J.M., Saffary R., Stirling W., Bruno K., Hess E.J., Lee M.K., Dawson V.L., Dawson T.M. Inclusion Body Formation and Neurodegeneration are Parkin-Independent in a Mouse Model of α-Synucleinopathy. J. Neurosci. 2006;26:3685-3696. *Co-first authors.

9. Thomas B., von Coelln R., Mandir A.S., Trinkaus D.B., Farah M.H., Leong Lim K., Calingasan N. Y., Flint Beal M., Dawson V.L., Dawson T.M. MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity. Neurobiol. Dis. 2007;26:312-322. (Determined methods, treated animals, prepared samples)

10. von Coelln R., Raible A., Gasser T., Asmus F. Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia. Mov. Dis. 2008;23:889-892.

11. Asmus F., von Coelln R., Boertlein A., Gasser T., Mueller J. (2009): Reverse sensory geste in cervical dystonia. Mov. Dis. 24, 297-300. (Involved in patient care, videotaping, preparation of manuscript)

12. Pantazis G, Psaras T, Krope K, von Coelln R., Fend F, Bock T, Schittenhelm J, Melms A, Meyermann R, Bornemann A. Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue. Clin Neuropathol 2010;29(6):378-83. (Involved in patient care, preparation of manuscript)

13. Asamoah V, von Coelln R., Savitt J, Lee LA. The many faces of celiac disease. Gastroenterol Hepatol (N Y). 2011;7(8):549-54. (Involved in patient care, preparation of manuscript)

Book Chapters

1. von Coelln R., Jinnah H.A., Savitt J.M.: Movement Disorders, The Johns Hopkins Internal Medicine Board Review 2010-2011, 3rd Edition, Edited by Miller R.G., Ashar B.H., Sisson S.D., Philadelphia, Mosby Elsevier, 2010.

2. von Coelln R., Kobayashi K., Kim J.H., et al.: Thalamotomy, Encyclopedia of Movement Disorders, Edited by Kompoliti K, Verhagen Metman L, Oxford, Academic Press. 2010.

3. Smyth S. F., von Coelln R., Savitt J.M.: Movement Disorders, The Johns Hopkins Internal Medicine Board Review, edited by Ashar B.H., Miller R.G., Sisson S.D., Philadelphia, Mosby Elsevier. 4th edition, 2012; 5th edition, 2015.

Abstracts (selected)

1. von Coelln R., Unsicker K., Krieglstein K. Putative neurotrophic effects of interleukins on cultured mesencephalic dopaminergic neurons from embryonic rat brain. Versammlung der Anatomischen Gesellschaft, Graz, 8.-11. Annals Anat. 1995;177(4),Suppl.,175-176.

2. von Coelln R., Kügler S., Bähr M., Schulz J.B. Caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. Society for Neuroscience Annual Meeting. 2000;765.8.

3. von Coelln R., Lim K.L., Thomas B., Savitt J.M., Stirling W., Hess E.J., Lee M.K., Dawson V.L., Dawson T.M. Characterization of mice overexpressing A53T-α-synuclein on a parkin-null background. Society for Neuroscience Annual Meeting. 2003;297.4.

4. von Coelln R., Raible A., Asmus F. Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia. 1. Deutscher Botulinumtoxin-Kongress. 2007;#64.

5. von Coelln R., Raible A., Asmus F. Treatment of camptocormia by ultrasound-guided deep ventral injection of botulinum toxin to the iliopsoas muscle. Mov Dis 2007;22 Suppl 16:258.

6. von Coelln, R., Barr E., Gruber-Baldini A.L., Reich S.G., Armstrong M.J., Shulman L.M. Motor Subtypes of Parkinson Disease are Unstable Over Time. Neurology 2015:84 Suppl 14:S48.002.

7. von Coelln R, Barr E., Gruber-Baldini A.L, Reich S.G., Armstrong M.J., Hanna-Pladdy B., Shulman L.M. Can we predict motor subtype fidelity in patients with tremor-dominant Parkinson disease? Mov Dis 2015;30 Suppl 1:130.

Invited Speeches

Local

1. von Coelln R., "Dopamine agonists", 17th Joint Conference of the Departments of Neurology of the Universities Munich and Tuebingen, Univ. of Munich Dept. of Neurology, Munich, Germany, 2001.

2. von Coelln R., "What's parkin got to do with it? Animal models on parkin's role in PD pathogenesis", weekly neuroscience conference, Dept. of Neurology, Univ. of Tuebingen, Tuebingen, Germany, 2006.

3. von Coelln R., "Camptocormia – syndrome, etiology, management", 24th Joint Conference of the Departments of Neurology of the Universities Munich and Tuebingen, Univ. of Tuebingen Dept. of Neurology, Tuebingen, Germany, 2008.

4. von Coelln R., “Subtypes of Parkinson Disease: New Concepts in an Era of Quantitative Phenotyping and Genetics”, University of Maryland Rehabilitation Network Annual Spring Conference 2016, Baltimore, MD, March 2016.

National

1. von Coelln R., "α-Synuclein-induced protein aggregation and neurodegeneration in vivo are independent of parkin", 77th Annual Meeting of the German Society for Neurology, Duesseldorf, Germany, 2004

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