Curriculum Vitae - Radboud Universiteit



Curriculum Vitae

Name: Tamás L. Kozicz M.D., Ph.D.

Date/Place of Birth: May 20, 1966, Tatabánya, Hungary

Nationality: Hungarian

Social Status: married, two children

1. Executive summary:

After finishing medical school in 1990, I received full training in gross anatomy, histology, embryology with special attention to functional neuroanatomy in Pécs (Hungary). I obtained my PhD degree in 1997 and the Hungarian habilitation degree in 2007. I spent two and a half years in the laboratory of Prof Akira Arimura at Tulane University in New Orleans, LA, USA as a post-doc. After returning to Hungary, I had established my own research group studying functional neuroanatomy of brain circuits regulating/controlling stress adaptation response at the Department of Anatomy in Pécs University in Pécs. This research has been supported by several grants from the Hungarian Science Foundation and Hungarian Academy of Science. In 2002 I moved to the Netherlands and in 2005 I was appointed assistant professor at Radboud University Nijmegen in the Department of cellular Animal Physiology. I am currently heading the Nijmegen Stress Adaptation Group, a research group probing structural and functional correlates of stress-related plasticity in the rodent brain and in human post-mortem brain samples. My group has established a fundamental research line with a strong translational aspect in stress (mal)adaptation and energy metabolism, with a special attention to neuronal mechanisms of sex differences. The outcome of various stress and feeding paradigms as well as adverse early life experience are in my focus by using a highly interdisciplinary approach integrating functional neuroanatomical, behavioral, (epi)genetic and physiological aspects of the action(s) of CRF-family of neuropeptides, with special focus on urocortin 1, in in vivo and in vitro model systems. In addition to urocortin 1, the messengers corticotropin-releasing factor (CRF), brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), leptin, ghrelin and cocaine- and amphetamine-related transcript peptide (CART) are of central interest too. My work is nationally as well as internationally recognized on the biological significance of urocortin 1. My research has been described in 85 publications in peer-reviewed journals, and cited more than 1300 times. I have acquired grants worth more than 2 million Euros. I received the prestigious Bolyai János Fellowship Award from the Hungarian Academy of Sciences, and Vidi Award of the Nederlands Organization for Scientific research (NWO).

2. Present positions:

Professor of Anatomy at the Department of Anatomy, Radboud University Nijmegen Medical Centre (0.9fte)

Associate professor of Clinical Anatomy at Structural and Cellular Biology/Human Genetic Center, Tulane University, New Orleans, LA, USA

Director; Prof SM. Hill and Prof. H. Andresson (0.1fte)

3. Education/training:

|INSTITUTION AND LOCATION |DEGREE |YEAR |FIELD OF STUDY |

|University Medical School, Pécs, Hungary |Habilitation |2007 |Medicine |

|University Medical School, Pécs, Hungary |PhD |1996 |Neuroscience |

| |(Summa cum laude) | | |

|US Medical Licensing Examinations, Philadelphia, MA, USA|- |1992 |Medicine |

|University Medical School, Pécs, Hungary |MD |1990 |Medicine |

| |(Summa cum laude) | | |

4. Professional experience:

1996-1998 Postdoctoral fellow at Tulane University-New Orleans;

director: Akira Arimura M.D., Ph.D.

1999 Visiting assistant professor at Tulane University-New Orleans for three months;

director: Akira Arimura M.D., Ph.D.

2000 Visiting assistant professor at Tulane University-New Orleans for three months;

director: Akira Arimura M.D., Ph.D.

2001 Visiting assistant professor at Tulane University-New Orleans for three months;

director: Akira Arimura M.D., Ph.D.

1998-2002 Assistant Professor, Department Human Anatomy, University of Pécs, Medical Faculty

director: György Sétáló M.D., Dc.S.

2002-2005 Postdoctoral Fellow; Department of Cellular Animal Physiology, Institute for Neuroscience, Faculty of Science, Radboud University Nijmegen;

Director: Prof E.W. Roubos

2005-2012 Assistant Professor at Department of Cellular Animal Physiology, Faculty of Science, Radboud University Nijmegen;

Director: Prof E.W. Roubos

20010- Aspiring Principle Investigator (PI) Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen;

Director Prof Dr. Paul Tiesinga.

5. Professional Awards and prizes:

1999-2002 Bolyai János Research Scholarship granted by the Hungarian Academy of Sciences

2001 and 2002 Hungarian State Eötvös Fellowship by the Hungarian Academy of Sciences

6. Research Grant Awards:

1998 Young Scientist Research Grant by University of Pécs (Hungary; 5KEuro)

2002. Research grant from the Hungarian Science Foundation (OTKA T 030412; 40KEuro)

2005-2010 VIDI grant (Nederlands Organization for Scientific Research (NOW) #864.05.008; the Netherlands; 0.8 MEuro)

2007-2010 Research grant by Schering Plough (former Organon) (280KEuro)

2007-2208 Research grant from European Graduate School for Neurosciences (45 KEuro)

2007-2010 Research grant by UMCN Dept. Anesthesiology (240 KEuro)

2007-2010 Research grant by Radboud University Nijmegen Faculty of Science, Mathematics and Informatics (240 KEuro)

2010-2014 Research grant by the Nederland's Research Organization (ALW#819.02.022; the Netherlands; 288 KEuro)

2012-2015 Research grant by the Hayward Foundation (550 K$)

7. Travel grants:

1992 Soros Foundation Hungary Travel Grant -ENA Meeting-Munich

1998 Hungarian Science Foundation Travel Grant -SFN Meeting-New Orleans

1999 Soros Foundation Hungary Travel Grant -SFN Meeting-Miami Beach

2000 MAT Travel Grant-SFN Meeting-New Orleans

2001 IBRO Travel Grant-Cajal Meeting-Madrid

2001 Society for Neuroscience Travel Grant

2001 Hungarian Science Foundation Travel Grant-SFN Meeting-New Orleans

8. Trainees:

Sietske Schootanus Master student 2004

Loes Bordewin Master student 2005

Nicole Derks PhD student 2005-present

Aniko Korosi PhD student PhD awarded in 2007

Marinella Calle PhD student PhD awarded in 2007

Xu Lu Master student 2007

Yvonne Hengeveld Master student 2007

Diane van Wijk PhD student PhD awarded in 2011

Tom Rouwette PhD student 2007-present

Linda Sterrenburg PhD student 2007-present

Xu Lu PhD student 2008-present; defence 12/12/2011

Balázs Gaszner PhD student PhD awarded in 2008

Bernard Bloom Master student 2008

Reinald Shyti Master student 2008

Maria Bevivino B.S. student 2009-2010

Claudia Conti B.S. student 2009-2010

Marcella Oonk Master student 2009-2010

Rick van der Doelen PhD student 2010-2014

Max Wiesmann B.S. student 2010 spring

Tsong Fang B.S. student 2010 spring

Peter Gordebeke Master student 2010-2011

Maarten van Beek B.S. student 2010 fall

Jan Verheijnen Master student 2011 fall-2012 summer

Donny Janssen Master student 2011 fall-2012 summer

Ilse Arnoldussen Master student 2011 fall-2012 summer

Max Wiesmann Master student 2011 fall-2012 summer

Tim Emmerzaal Master student 2011 fall-2010 summer

Ilse Arnoldussen PhD student 2011-2015

Carola Janssen PhD student 2011-2015

Pieter Schipper PhD student 2011-2014

Dr Xu Lu Post-doc 2012-2013

9. Scientific papers in peer reviewed journals:

86 scientific (peer review) publications

Number of citations: 1361

10. Peer-reviewed publications:

1) Shah NS, Pugh PC, Nam H, Rosenthal DT, van Wijk D, Gaszner B, Kozicz T, Kerman IA. A Subset of Presympathetic-Premotor Neurons within the Centrally Projecting Edinger-Westphal Nucleus Expresses Urocortin-1. J Chem Neuroanat. 2013 May 21. doi:pii: S0891-0618(13)00051-3. 10.1016/j.jchemneu.2013.04.004. [Epub ahead of print] PubMed PMID: 23707488.

2) Emmerzaal TL, Doelen RH, Roubos EW, Kozicz T. Orexinergic innervation of urocortin1 and cocaine and amphetamine regulated transcript neurons in the midbrain centrally projecting Edinger-Westphal nucleus. J Chem Neuroanat. 2013 Aug 16. doi:pii: S0891-0618(13)00064-1. 10.1016/j.jchemneu.2013.07.004. [Epub ahead of print] PubMed PMID: 23958928.

3) Armbruszt S, Abraham H, Figler M, Kozicz T, Hajnal A. Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats. J Chem Neuroanat. 2013 May;50-51:75-84.

4) Emmerzaal TL, Kozicz T. Nesfatin-1; Implication In Stress And Stress-Associated Anxiety And Depression. Curr Pharm Des. 2013 Mar 25. [Epub ahead of print] PubMed PMID: 23537084.

5) Janssen D, Kozicz T. Is it really a matter of simple dualism? Corticotropin-releasing factor receptors in body and mental health. Front Endocrinol (Lausanne). 2013;4:28. doi: 10.3389/fendo.2013.00028.

6) Morava E, Kozicz T. Mitochondria and the economy of stress (mal)adaptation. Neurosci Biobehav Rev. 2013 May;37(4):668-80.

7) Vanelderen P, Rouwette T, Kozicz T, Heylen R, Van Zundert J, Roubos EW, Vissers K. Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. Reg Anesth Pain Med. 2013 Mar-Apr;38(2):124-30.

8) van der Doelen RH, Homberg JR, Kozicz T. Adaptive fitness; early life adversity improves adult stress coping in heterozygous serotonin transporter knockout rats. Mol Psychiatry. 2013 Jan 15. doi: 10.1038/mp.2012.186. [Epub ahead of print] PubMed PMID: 23319004.

9) Ryabinin AE, Tsoory MM, Kozicz T, Thiele TE, Neufeld-Cohen A, Chen A, Lowery-Gionta EG, Giardino WJ, Kaur S. Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol. 2012 Jun;46(4):349-57.

10) van Wingen GA, Geuze E, Caan MW, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G. Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15508-13.

11) Derks NM, Pintér O, Zuure W, Ledent C, Watanabe M, Molnár CS, Wei Y, Roubos EW, Wu S, Hrabovszky E, Zelena D, Kozicz T. Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress. J Neuroendocrinol. 2012 Nov;24(11):1447-61.

12) Wortmann SB, Vaz FM, Gardeitchik T, Vissers LE, Renkema GH, Schuurs-Hoeijmakers JH, Kulik W, Lammens M, Christin C, Kluijtmans LA, Rodenburg RJ, Nijtmans LG, Grünewald A, Klein C, Gerhold JM, Kozicz T, van Hasselt PM, Harakalova M, Kloosterman W, Barić I, Pronicka E, Ucar SK, Naess K, Singhal KK, Krumina Z, Gilissen C, van Bokhoven H, Veltman JA, Smeitink JA, Lefeber DJ, Spelbrink JN, Wevers RA, Morava E, de Brouwer AP. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nat Genet. 2012 Jun 10;44(7):797-802.

13) Spencer SJ, Xu L, Clarke MA, Lemus M, Reichenbach A, Geenen B, Kozicz T and Andrews ZB. Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress. Biol. Psychiatry. 2012 Sep 15;72(6):457-65.

14) Rouwette T, Vanelderen P, Roubos EW, Kozicz T, Vissers K. The amygdala, a relay station for switching on and off pain. Eur J Pain. 2011 Dec 19. doi:10.1002/j.1532-2149.2011.00071.x. [Epub ahead of print] PubMed PMID: 22337528.

15) Roubos EW, Dahmen M, Kozicz T, Xu L. Leptin and the hypothalamo-pituitary-adrenal stress axis. Gen Comp Endocrinol. 2012 Jan 28. [Epub ahead of print] PubMed PMID: 22293575.

16) Gaszner B, Kormos V, Kozicz T, Hashimoto H, Reglodi D, Helyes Z. The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus. Neuroscience. 2012 Jan 27;202:283-99. Epub 2011 Dec 9. PubMed PMID: 22178610.

17) Gardeitchik T, de Leeuw N, Nijtmans L, Jira P, Kozicz T, Czako M, van de Burgt I, Morava E. Infant with MCA and severe cutis laxa due to a de novo duplication 11p of paternal origin. Am J Med Genet A. 2012 Feb;158A(2):469-72. doi: 10.1002/ajmg.a.34410. Epub 2011 Dec 15. PubMed PMID: 22173889.

18) Xu L, Scheenen WJ, Roubos EW, Kozicz T. Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. Gen Comp Endocrinol. 2011 Dec 7. [Epub ahead of print] PubMed PMID: 22166814.

19) Binkhorst M, Wortmann SB, Funke S, Kozicz T, Wevers RA, Morava E. Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model : "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. J Inherit Metab Dis. 2011 Dec 2. [Epub ahead of print] PubMed PMID: 22134542.

20) Sterrenburg L, Gaszner B, Boerrigter J, Santbergen L, Bramini M, Elliott E, Chen A, Peeters BW, Roubos EW, Kozicz T. Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat. PLoS One. 2011;6(11):e28128. Epub 2011 Nov 23. PubMed PMID: 22132228; PubMed Central PMCID: PMC3223222.

21) Bloem B, Xu L, Morava E, Faludi G, Palkovits M, Roubos EW, Kozicz T. Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls. Neuropharmacology. 2012 Jan;62(1):297-303.

22) Sterrenburg L, Gaszner B, Boerrigter J, Santbergen L, Bramini M, Roubos EW, Peeters BW, Kozicz T. Sex-dependent and differential responses to acute restraint stress of corticotropin-releasing factor-producing neurons in the rat paraventricular nucleus, central amygdala, and bed nucleus of the stria terminalis. J Neurosci Res. 2011 Sep 15. doi: 10.1002/jnr.22737. [Epub ahead of print] PubMed PMID: 21922520.

23) Rouwette T, Vanelderen P, Reus MD, Loohuis NO, Giele J, Egmond JV, Scheenen W, Scheffer GJ, Roubos E, Vissers K, Kozicz T. Experimental neuropathy increases limbic forebrain CRF. Eur J Pain. 2011 Jun 17.

24) Rouwette T, Klemann K, Gaszner B, Scheffer GJ, Roubos EW, Scheenen WJ, Vissers K, Kozicz T. Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Neuroscience. 2011 Jun 2;183:15-24.

25) Sterrenburg L, Borch A, Peeters BW, Pintér O, Zelena D, Roubos EW, Kozicz T. Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat. Brain Res. 2011 Jun 29;1398:21-9.

26) Kozicz, T., Bittencourt, J., May, P., Reiner, A., Gamlin, P., Palkovits, M., Horn, A., Toledo, C., Ryabinin, A. (in press) The Edinger-Westphal nucleus: a historical, structural and functional perspective on a dichotomous terminology. Review. J Comp Neurol. 2011 Jun 1;519(8):1413-34.

27) Kozicz T, Strerrenburh L, Xu L. Does midbrain urocortin-1 matter; from stress adaptaton to energy metabolism. Review, Stress. 2011 Jul;14(4):376-83.

28) Roubos EW, Van Wijk DC, Kozicz T, Scheenen WJ, Jenks BG. Plasticity of melanotrope cell regulations in Xenopus laevis. Eur J Neurosci. 2010 Dec;32(12):2082-6.

29) Xu L, Scheenen WJ, Leshan RL, Patterson CM, Elias CF, Bouwhuis S, Roubos EW, Myers MG Jr, Kozicz T. Leptin Signaling Modulates the Activity of Urocortin 1 Neurons in the Mouse Nonpreganglionic Edinger-Westphal Nucleus. Endocrinology. 2011 Mar;152(3):979-88.

30) Janzsó G, Valcz G, Thuma A, Szőke B, Lendvai Z, Abrahám H, Kozicz T, Halasy K. Cocaine- and amphetamine-regulated transcript (CART) peptide- immunopositive neuronal elements in the lateral septum: Rostrocaudal distribution in the male rat. Brain Res. 2010 Nov 29;1362:40-7.

31) Xu L, Bloem B, Gaszner B, Roubos EW, Kozicz T. Stress-related changes in the activity of cocaine- and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger-Westphal nucleus in the rat. Neuroscience. 2010 Oct 13;170(2):478-88.

32) Morava E, Gardeitchik T, Kozicz T, de Boer L, Koene S, de Vries MC, McFarland R, Roobol T, Rodenburg RJ, Verhaak CM. Depressive behaviour in children diagnosed with a mitochondrial disorder. Mitochondrion. 2010 Aug;10(5):528-33.

33) Rouwette TP, Kozicz T, Olde Loohuis NF, Gaszner B, Vreugdenhil E, Scheffer GJ, Roubos EW, Vissers KC, Scheenen WJ. Acute pain increases phosphorylation of DCLK-long in the Edinger-Westphal nucleus but not in the hypothalamic paraventricular nucleus of the rat. J Pain. 2010 Oct;11(10):930-40.

34) Okere B, Xu L, Roubos EW, Sonetti D, Kozicz T. Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus. Brain Res. 2010 Mar 4;1317:92-9.

35) Kozicz T. The missing link; the significance of urocortin 1/urocortin 2 in the modulation of the dorsal raphe serotoninergic system. Mol Psychiatry. 2010 Apr;15(4):340-1.

36) Vanelderen P, Rouwette T, Kozicz T, Roubos E, Van Zundert J, Heylen R, Vissers K. The role of brain-derived neurotrophic factor in different animal models of neuropathic pain. Eur J Pain. 2010 May;14(5):473.e1-9. Review.

37) Derks NM, Gaszner B, Bernhardt K, Roubos EW, Kozicz T. Sex-specific expression of BDNF and CART in the midbrain non-preganglionic Edinger-Westphal nucleus in the rat. Peptides. 2009 Dec;30(12):2268-74.

38) Gaszner B, Jensen KO, Farkas J, Reglodi D, Csernus V, Roubos EW, Kozicz T. Effects of maternal separation on dynamics of urocortin 1 and brain-derived neurotrophic factor in the rat non-preganglionic Edinger-Westphal nucleus. Int J Dev Neurosci. 2009 Aug;27(5):439-51.

39) Gaszner B, Van Wijk DC, Korosi A, Jozsa R, Roubos EW, Kozicz T. 2009. Diurnal expression of period 2 and urocortin 1 in neurones of the non-preganglionic Edinger-Westphal nucleus in the rat. Stress 12(2):115-24.

40) Xu L, Bloem B, Gaszner B, Roubos EW, Kozicz T. Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus. Neuroscience. 2009 Sep 15;162(4):1141-9.

41) Van Wijk DC, Xu L, Spiegelberg L, Struik RF, Meijer KH, Gaszner B, Kozicz T, Roubos EW. Ultrastructural and immunocytochemical characterization of the rat non-preganglionic Edinger-Westphal nucleus. Gen Comp Endocrinol. 2009 Oct;164(1):32-9.

42) Derks NM, Müller M, Gaszner B, Tilburgh-Ouwens D, Roubos EW, Kozicz T. 2008. Housekeeping genes revisited: Different expressions depending on gender, brain area and stressor. Neuroscience. 156(2); 305-9.

43) Koene S, Kozicz, TL, Rodenburg RJ, Verhaak CM, de Vries MC, Wortman S, van de Heuvel L, Smeitink, JA, Morava, A. 2009. Major depression in adolescent children consecutively diagnosed with mitochondrial disorder. J Affect Disord. . 114(1-3):327-32.

44) Kozicz T, Bordewin LA, Czéh B, Fuchs E, Roubos, EW. 2008 Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew. Pshychoneuroendocrinology PMID: 18394812

45) Kozicz T, Tilburgh-Ouwens D, Faludi G, Palkovits M, Roubos EW. 2008. Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression. Neuroscience 152(4):1015-1023.

46) Roubos EW, Lázár G, Calle M, Barendregt HP, Gaszner B, Kozicz T. 2008. Brain distribution and evidence for both central and neurohormonal actions of cocaine- and amphetamine-regulated transcript peptide in Xenopus laevis. Journal of Comparative Neurolology. 507(4):1622-1638.

47) Kozicz T. 2007. CRF and CRF-related peptides in stress adaptation: From invertebrates to man. General and Comparative Endocrinology 153(1-3):198-199.

48) Derks NM, Roubos EW, Kozicz T. 2007. Presence of estrogen receptor beta in urocortin 1-neurons in the mouse non-preganglionic Edinger-Westphal nucleus. General and Comparative Endocrinology 153(1-3):228-234.

49) Kozicz T. 2007. On the role of urocortin 1 in the non-preganglionic Edinger–Westphal nucleus in stress adaptation. General and Comparative Endocrinology 153(1-3):235-240.

50) Korosi A, Kozicz T, Richter J, Veening JG, Olivier, B, Roubos EW. 2007. Corticotropin-releasing factor, urocortin 1, and their receptors in the mouse spinal cord. Journal of Comparative Nueorology 502(6):973-989.

51) Gaszner B, Korosi A, Palkovits M, Roubos EW, Kozicz T. 2007. Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger-Westphal nucleus. Journal of Comparative Neurology 500(4):708-719.

52) Calle M, Kozicz T, van der Linden E, Desfeux A, Veening JG, Barendregt HP, and Roubos EW. 2006. Effect of starvation on Fos and neuropeptide immunoreactivities in the brain and pituitary gland of Xenopus laevis. General and Comparative Endocrinology 147:237-246.

53) Korosi A, Veening JG, Kozicz T, Henckens M, Dederen J, Groenink L, van der Guten J, Olivier B, and Roubos EW. 2006. Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain. Brain Research 1072:46-54.

54) Calle M, Claassen IEWM, Veening JG, Kozicz T, Roubos EW, and Barendregt HP. 2005. Opioid peptides, CRF, and urocortin in cerebrospinal fluid-contacting neurons in Xenopus laevis. Trends in Comparative Endocrinology and Neurobiology 1040:249-252.

55) Korosi A, Schotanus S, Olivier B, Roubos EW, and Kozicz T. 2005. Chronic ether stress-induced response of urocortin 1 neurons in the Edinger-Westphal nucleus in the mouse. Brain Research 1046:172-179.

56) Calle M, Corstens GJH, Wang LC, Kozicz T, Denver RJ, Barendregt HP, and Roubos EW. 2005. Evidence that urocortin I acts as a neurohormone to stimulate alpha-MSH release in the toad Xenopus laevis. Brain Research 1040:14-28.

57) Gaszner B, Csernus V, and Kozicz T. 2004. Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger-Westphal nucleus in the rat. Journal of Comparative Neurology 480:170-179.

58) Lázár G , Calle M, Roubos EW, and Kozicz T. 2004. Immunohistochemical localization of cocaine- and amphetamine-regulated transcript peptide in the central nervous system of the frog Rana esculenta. Journal of Comparative Neurology 477:324-339.

59) Seress L, Abraham H, Dóczi T, Lázár G , and Kozicz T. 2004. Cocaine- and amphetamine-regulated transcript peptide (CART) is a selective marker of rat granule cells and of human mossy cells in the hippocampal dentate gyrus. Neuroscience 125:13-24.

60) van de Bovenkamp-Janssen M, Scheenen WJJM, Kuijpers-Kwant FJ, Kozicz T, Veening JG, van Luijtelaar ELJM, McEnery MW, and Roubos EW. 2004. Differential expression of high voltage-activated Ca2+ channel types in the rostral reticular thalamic nucleus of the absence epileptic WAG/Rij rat. Journal of Neurobiology 58:467-478.

61) Kozicz T, Korosi A, Korsman C, Tilburg-Ouwens D, Groenink L, Veening J, Van der Gugten J, Roubos E, and Olivier B. 2004. Urocortin expression in the Edinger-Westphal nucleus is down-regulated in transgenic mice over-expressing neuronal corticotropin-releasing factor. Neuroscience 123:589-594.

62) Gaszner B and Kozicz T. 2003. Interaction between catecholaminergic terminals and urocortinergic neurons in the Edinger-Westphal nucleus in the rat. Brain Research 989:117-121.

63) Lubics A, Reglődi D, Szelier M, Lengvári I, and Kozicz T. 2003. Comparative distribution of urocortin- and CRF-like immunoreactivities in the nervous system of the earthworm Lumbricus terrestris. Peptides 24:205-213.

64) Hunyady B, Zólyomi A, Czimmer J, Mózsik G, Kozicz T, Buzás E, Tanaka S, Ichikawa A, Nagy A, Palkovits M, and Falus A. 2003. Expanded parietal cell pool in Transgenic mice unable to synthesize histamine. Scandinavian Journal of Gastroenterology 38:133-140.

65) Kozicz T. 2003. Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat. Neuroscience 116:315-320.

66) Kozicz T. 2003. Dopamine and cyclic AMP-regulated phosphoprotein immunoreactive neurons are innervated by axon terminals immunopositive for vasoactive intestinal polypeptide in the bed nuclei of the stria terminalis and central nucleus of the amygdala. Brain Research 962:237-243.

67) Kozicz T and Arimura A. 2002. Dopamine- and cyclic AMP-regulated phosphoprotein-immunoreactive neurons activated by acute stress are innervated by fiber terminals immunopositive for pituitary adenylate cyclase-activating polypeptide in the extended amygdala in the rat. Regulatory Peptides 109:63-70.

68) Kozicz T, Arimura A, Maderdrut JL, and Lázár G . 2002. Distribution of urocortin-like immunoreactivity in the central nervous system of the frog Rana esculenta. Journal of Comparative Neurology 453:185-198

69) Kozicz T. 2002. Met-enkephalin immunoreactive neurons recruited by acute stress are innervated by axon terminals immunopositive for tyrosine hydroxylase and dopamine-alpha-hydroxylase in the anterolateral division of bed nuclei of the stria terminalis in the rat. European Journal of Neuroscience 16:823-835.

70) Kozicz T and Arimura A. 2002. Distribution of urocortin in the rat's gastrointestinal tract and its colocalization with tyrosine hydroxylase. Peptides 23:1711.

71) Kozicz T, Li, M. and Arimura, A. 2001. The activation of urocortin immunoreactive neurons in the Edinger-Westphal nucleus following acute pain stress. Stress 4(2) 85-90.

72) Kozicz T and Arimura A. 2000. Synaptic interaction between galanin immunoreactive neurons and axon terminals immunopositive for VIP and PACAP in the bed nucleus of the stria terminalis in the rat. Vip, Pacap, Glucagon, and Related Peptides ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 921: 327-332 2000 921:327-332.

73) Kozicz T. 2001. Axon terminals containing tyrosine hydroxylase- and dopamine-beta-hydroxylase immunoreactivity form synapses with galanin immunoreactive neurons in the lateral division of the bed nucleus of the stria terminalis in the rat. Brain Research 914:23-33.

74) Kozicz T and Lázár G . 2001. Colocalization of GABA, enkephalin and neuropeptide Y in the tectum of the green frog Rana esculenta. Peptides 22:1071-1077.

75) Kozicz T and Arimura A. 2001. Axon terminals containing CGRP-immunoreactivity form synapses with CRF- and Met-enkephalin-immunopositive neurons in the laterodorsal division of the bed nucleus of the stria terminalis in the rat. Brain Research 893:11-20.

76) Reglődi D, Somogyvári-Vigh A, Vigh S, Kozicz T, and Arimura A. 2000. Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke 31:1411-1417.

77) Kozicz T, Vigh S, and Arimura A. 1998. Immunohistochemical evidence for PACAP and VIP interaction with Met-enkephalin and CRF containing neurons in the bed nucleus of the stria terminalis. Vip, Pacap, and Related Peptides, Annal of the New York Academy of Sciences 865:523-528.

78) Yanaihara H, Vigh S, Kozicz T, Somogyvári-Vigh A, and Arimura A. 1998. Immunohistochemical demonstration of the intracellular localization of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat testis using the stamp preparation. Regulatory Peptides 78:83-88.

79) Kozicz T, Vigh S, and Arimura A. 1998. The source of origin of PACAP- and VIP-immunoreactive fibers in the laterodorsal division of the bed nucleus of the stria terminalis in the rat. Brain Research 810:211-219.

80) Kozicz T, Yanaihara H, and Arimura A. 1998. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. Journal of Comparative Neurology 391:1-10.

81) Kozicz T, Vigh S, and Arimura A. 1997. Axon terminals containing PACAP- and VIP-immunoreactivity form synapses with CRF-immunoreactive neurons in the dorsolateral division of the bed nucleus of the stria terminalis in the rat. Brain Research 767:109-119.

82) Maderdrut JL, Lázár G , Kozicz T, and Merchenthaler I. 1996. Distribution of neuromedin U-like immunoreactivity in the central nervous system of Rana esculenta. Journal of Comparative Neurology 369:438-450.

83) Sétáló G, Lázár G , and Kozicz T. 1994. The Gonadotropin-Releasing-Hormone (Gnrh) Neuron System of the Clawed Toad Xenopus-Laevis. Acta Biologica Hungarica 45:427-440.

84) Kozicz T and Lázár G . 1994. The Origin of Tectal Npy Immunopositive Fibers in the Frog. Brain Research 635:345-348.

85) Lázár G , Maderdrut JL, Trasti SL, Liposits Z, Tóth P, Kozicz T, and Merchenthaler I. 1993. Distribution of Proneuropeptide Y-Derived Peptides in the Brain of Rana-Esculenta and Xenopus-Laevis. Journal of Comparative Neurology 327:551-571.

86) Lázár G and Kozicz T. 1990. Morphology of Neurons and Axon Terminals Associated with Descending and Ascending Pathways of the Lateral Forebrain-Bundle in Rana-Esculenta. Cell and Tissue Research 260:535-548.

11. Organization of International congresses/symposia:

2004, January; International Symposium on the ”Neurobiology of CRF related Neuropeptides” at Radboud University Nijmegen, Faculty of Science, Mathematics and Informatics.

2007, June; Chair; Symposium entitled "Gender differences in stress adaptation; are women more vulnerable to stress then men?"; 6th Endo-Neuro-Psycho (ENP) Meeting; Doorwerth, the Netherlands

2009 October 1-2 Main organizer of EURON PhD days; Nijmegen, the Netherlands

2011 June; Chair; Symposium entitled "Gut feeling; how does the gut control brain functions?"; 10th Endo-Neuro-Psycho (ENP) 2011 Meeting; Lunteren, The Netherlands

2012 May; Chair; Symposium entitled "Zooming in on CRF neuronal system in the extended amygdala in depression" 11th Endo-Neuro-Psycho (ENP) 2012 Meeting; Lunteren, The Netherlands

2013 May; Chair; Symposium entitled; Why Ghrelin; recent advances in ghrelin research; 12th Endo-Neuro-psycho (ENP) Meeting; Lunteren, The Netherlands

Coming:

2013 July; Chair; Symposium entitled “Stress adaptation and maladaptation - dedicated to the memory of Wylie Vale”; 17th Congress of International Comparative Endocrinology; Barcelona, Spain, July 15-19, 2013

2013 August; Chair; Symposium entitled “Our past dictates our future”; 43rd Annual Meeting of the International Society of Psychoneuroendocrinology

Leiden, the Netherlands, August 20-22, 2013

12. Professional Societies:

Federation of European Neuroscience

Society for Neuroscience (USA)

Society of Hungarian Anatomists, Histologists and Embryologists

Endocrine Society (USA)

Cajal Club (International)

13. National scientific activities:

Veni Committee NWO, ALW 2011

Veni Committee NWO, ALW 2012

Veni Committee NOW, ALW, 2013

Donders Institute Grant Evaluation committee (2009-2012); Radboud University Nijmegen, Nijmegen the Netherlands

Youth and Identity Committee; Utrecht University, The Netherlands

14. International scientific activities:

Member of the Editorial Board of Journal of Chemical Neuroanatomy (2010-) and Frontiers of Endocrinology (2011-)

Scientifica (2012-)

Reviewed articles for: Molecular Psychiatry, Translational Psychiatry, Biological Psychiatry, Annals of Neurology, Journal of Comparative Neurology, Brain Research, Brain Research Bulletin, Neuroscience, Neuroscience Letters, Peptides, Journal of Chemical Neuroanatomy and General and Comparative Endocrinology, Alcoholism: Clinical and Experimental Research, Addiction Biology, Neuropharmacology, Regulatory Peptides; Journal of Clinical Endocrinology and Metabolism

15. Grant reviewer activity

National Science Foundation

Hungarian Science Foundation

Nederland's Organization for Scientific Research Earth and Life Sciences subdivision

Nederland's Organization for Scientific Research Rubicon subdivision

Nederland's Organization for Scientific Research Veni Scheme

Israel Science Foundation

National Health and Medical Research Council Australian Government

16. State-of the art lectures:

1. Kozicz, T. Neurons in the Edinger-Westphal and paraventricular hypothalamic nuclei respond in a differentiated manner to a repeated stressor. LARC Meeting Paris, France, October 15, 2004.

2. Kozicz, T. A novel candidate mechanism in stress adaptation, the Edinger-Westphal urocortin 1 system. Manchester, CECE, August 31, 2006.

3. Kozicz, T. (2007) A novel stress adaptation mechanism; the Edinger-Westphal urocortin 1 system. Annual Meeting of the Hungarian Neuroscience Association, Pécs, Hungary, February 12.

4. Kozicz, T., Lu, X., Gaszner, B., Roubos, E.W. (2007) Leptin modulates the activity of urocortin 1 neurons in the rat brain. Hans Selye Centennial Symposium, Montreal, Québec, Canada, July 13.

5. Kozicz, T. (2008) Dysregulation of cocaine and amphetamine regulated trasncript and nesfatin-1 in the midbrain of depressed sucide victims. 2nd Conference of Brain NetEurope, Munich, December 12.

6. Kozicz, T. (2009) Leptin controls the activity of urocortin-1 neurons in the rodent Edinger-Westphal nucleus. Nutrition, Metabolism and Brain, Amsterdam, The Netherlands; 2009 May 14.

7. Kozicz, T. (2009) 'Adaptation, energy metabolism and depression. 13th EURON PhD Days, Nijmegen, The Netherlands, October 2.

8. Kozicz, T. (2010) Urocortin 1 and stress and depression. International Congress on Neuroendocrinology, Rouen, France, July 13.

9. Kozicz, T. (2011) Urocortin1 and the moody brain; Alcoholism and Stress; Volterra Italy, May 3-6.

10. Kozicz, T. (2011) Midbrain urocortin 1; a review of recent advances; FAME; Pecs, Hungary, June 8-11.

11. Kozicz, T. (2011) Mitochondria and Stress (Mal)adaptation. 10th Symposium on Cathecholamines and other Neurotransmitters in Stress; Smolenice Castle, Slovakia, June 25-30.

12. Kozicz, T. (2012) Mitochondria and stress. 32nd European Winter Conference on Brain Research, Villar-sur-Ollon, Switzerland, March 11-17.

13. Kozicz, T. (2013) Midbrain urocortin 1 and energy metabolism. 2nd NASCE Meeting, Qeretaro, Mexico, May 22-25.

17. Invited lectures/seminars:

1. Kozicz T. Neuropetide interactions in the rat forebrain and midbrain: their possible role in stress regulation, New Orleans, Tulane University, Fall Seminar 2000.

2. Kozicz T. Function neroanatomy of urocortin in the Edinger-Westphal nucleus; from stress to drugs of abuse 4th World Congress on Stress, Edinburgh, Scotland, 2002.

3. Kozicz T, Korosi A., Korsman K., Tilburg-Ouwen D., Groenink L., Roubos E and Olivier B. Urocortin expression in the Edinger-Westphal nucleus is down-regulated in transgenic mice over-expressing neuronal corticotropin releasing factor. MITT IX. Konferenciája, 2003, Balatonfüred

4. Kozicz, T. (2004) A novel stress adaptation neuronal circuit; functional neuroanatomy of urocortin in the Edinger-Westphal nucleus. University Groningen, Groningen, March 21, 2004.

5. Derks, N.M., Gazsner, B., Ledent, C., Roubos, E.W., Kozicz, T. (2007) Gender differences in urocortin 1 mRNA expression in the non-preganglionic Edinger-Westphal nucleus of mouse and rat? Endo-Neuro-Psycho Meeting Doorwerth, June 5

6. Gaszner, B., Roubos, E.W., Kozicz, T. (2007) Plastic responses to stress by urocortin 1 neurons in the non-preganglionic Edinger Westphal nucleus. EURON PhD student meeting, Brussels, Belgium, September 13

7. Kozicz, T. Does Urocortin 1 matter? UMC Utrecht, Utrecht, September 23, 2006.

8. Kozicz, T. The role of urocortin 1 in stress adaptation, Charles University, 1st Medical Faculty, Prague, Check Republic, December 12, 2006.

9. Kozicz, T. (2008) Does urocortin-1 matter? Weizmann Institute, Rehovot, Isreal, May 27

10. Kozicz, T. (2008) Biological significance of urocortin-1. University of Pennsylvania, Philadelphia, November 11.

11. Kozicz, T. (2008) Urocortin-1; past, present and the future. Max Planck Institute for Psychiatry, Munich, December 11.

12. Kozicz, T. Brain Awareness Week in Nederland by Neurofederatie; Kandinsky College Nijmegen; March 16 2009.

13. Kozicz, T. 2009. Stress adaptation. DCN, Nijmegen, March 19.

14. Kozicz, T. (2009) Urocortin-1; present, past and future. University of California Irvine, Irvine, CA, USA; 2009 September 2.

15. Kozicz, T. (2009) Does Urocortin matter? Tulane University; New Orleans, LA, USA, 2009 September 29.

16. Kozicz, T. (2011) Zooming in on the midbrain urocortin 1 system; Rudolf Magnus Institute for Neurosciences; Utrecht, The Netherlands; July 1.

17. Kozicz, T. (2011 Oct.) The midbrain Edinger-Westphal nucleus as an integrative center for stress adaptation and energy metabolism; Weizmann Institute of Science, Rehovot, Israel. Oct. 25.

18. Kozicz, T. (2012) Suboptimal mitochondrial function in the etiology of depression; RUN UMCN, Nijmegen, The Netherlands; Feb.6.

19. Morava, E and Kozicz, T. Economy of stress (mal)adaptation; Donders Seminar Series, Nijmegen, The Netherlands; Feb. 20.

20. Kozicz, T. (2012) Does midbrain urocortin 1 matter?; a 15-year journey from stress (mal)adaptation to energy metabolism; Tulane University, New Orleans, LA, USA; Feb. 23.

20. Kozicz, T (2012) Midbrain urocortin1 linking stress and energy metabolism; University of Cincinnati, Cincinnati, OH, USA, October 25.

21. Kozicz, T (2012) Midbrain urocortin1 linking stress and energy metabolism; University of Michigan, Ann Arbor, MI, USA, November 29.

18. Teaching experience:

1996. Gross anatomy, embryology and histology[1] (220 teaching hours/year); Pécs University, Medical Faculty

1989-1996 Neuroscience1 (110 teaching hours/year); Pécs University, Medical Faculty

1997 Gross Anatomy[2] (190 teaching hours); Tulane University Medical School, New Orleans

1998-2002 Gross anatomy, embryology and histology1 (220 teaching hours/year); Pécs University, Medical Faculty

1998-2002 Neuroscience1 (110 teaching hours/year); Pécs University, Medical Faculty

2004- Dissection of the human brain[3] (20 teaching hours); Radboud University Medical Centre, Department of Anatomy

2005- Neurophysiology[4] (42 teaching hours); Radboud University, Faculty of Science, Department of Cellular Animal Physiology

2006- Human biology (12 teaching hours); Radboud University, Dept Cellular Animal Physiology

2007- Functional morphology (28 teaching hours); Radboud University Medical Centre, Department of Anatomy

2009- Neurobiology of (Mal)adaptation (6 teaching hours); Cognitive Neuroscience Master program, RUN

2012 Research Methods, Human Genetics Program, Tulane University, New Orleans, LA, USA

2013 T1 Neuroscience program, Tulane University Medical School

2013 HELIX-Neuroscience program, Tulane University Medical School

19. Educational tasks:

2009-2012 Coordinator of the Course Human Biology Thema 4, Radboud University Nijmegen, Faculty of Science

2010-2013 Coordinator of the course Stress: for better and for worst; Master Medical Biology Program; Radboud University Nijmegen, Faculty of Science

2010-2013 Coordinator of Trends in Biomedical Sciences II; Master Medical Biology Program, Radboud University Nijmegen, Faculty of Science

2009-2012 Member of the Lecturer team Theme 6, Radboud University Nijmegen, Faculty of Science

2009-2012 Member of the Exam Committee Biological Sciences; Radboud University Nijmegen, Faculty of Science

2010-2012 Member of the Educational Committee for Biological Science; Radboud University Nijmegen, Faculty of Science

20. Educational awards:

1998 Best Teacher of Year[5] 1998 Pécs University, Medical Faculty

2003 Best Teacher of Year5 2003 Pécs University, Medical Faculty

2004 Best Teacher of Year5 2004 Pécs University, Medical Faculty

21. Management tasks:

Member of the Faculty Employee Board; Radboud University Nijmegen, Faculty of Science

Member of the Grant Evaluation Committee Donders Institute for Brain Cognition and Behaviour; Donders Institute, Radboud University Nijmegen, Faculty of Science

Ad hoc committee for Animal Research in Donders Institute for Brain Cognition and Behaviour; Donders Institute, Radboud University Nijmegen, Faculty of Science

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[1] 20-25 students per group

[2] 25-30 student per group

[3] 40 students per group

[4] 12 students in the group

[5] Best Teacher of the Year award is given by the students. At the end of their six-year training, they have to name 3 teachers (one from basic, pre-clinical and clinical subjects) they found the best during their six years of training.

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