CURRICULUM VITAE - University of Colorado
Mark Allen Brown, MD
CURRICULUM VITAE
Personal Data
Business Address: Section of Pediatric Pulmonology and Sleep Medicine
University of Colorado Anschutz Medical Campus and
Breathing Institute, Children’s Hospital Colorado
13123 East 16th Avenue, B395
Aurora, Colorado 80045
720-777-6181
mark.brown@
Education
1975-1979 BA (Zoology) University of Texas at Austin
1979-1983 MD University of Texas Medical
School at Houston
Postgraduate Education
1983-1986 Resident in Pediatrics University of Oklahoma
College of Medicine
1987-1990 Fellow, Pediatric Pulmonary University of Arizona
Diseases College of Medicine
Academic Appointments
1986-1987 Pediatric Chief Resident University of Oklahoma
College of Medicine
1989-1990 Attending Physician, University of Arizona
Pediatric Pulmonology and College of Medicine
Critical Care Section
1990-1994 Assistant Professor of Pediatrics University of Virginia
College of Medicine
1993-1995 Head, Division of Pediatric University of Virginia
Pulmonary Medicine College of Medicine
1994-1995 Assistant Professor of University of Virginia
Clinical Pediatrics College of Medicine
1995-1999 Assistant Professor of University of Arizona
Clinical Pediatrics College of Medicine
1999-2005 Associate Professor of University of Arizona Clinical Pediatrics College of Medicine
2005-2016 Professor of Pediatrics University of Arizona College of Medicine
2005-2016 Adjunct Professor of Arizona State University
Nursing College of Nursing
2005-2016 Medical Director, Children’s Banner University Medical
Multi-Specialty Clinic Group/University of Arizona
College of Medicine
2006-present Adjunct Professor of Clinical Midwestern University, Arizona Education College of Osteopathic Medicine
2016-present Professor of Pediatrics University of Colorado/
Children’s Hospital of Colorado
2016-present Associate Medical Director The Breathing Institute,
University of Colorado/
Children’s Hospital of Colorado
2016–present Medical Director Respiratory Therapy, Children’s
Hospital of Colorado
Certification and Licensure
a) Certification
American Board of Pediatrics 1988 #36787
American Board of Pediatrics, 1993 #207443
Sub-Board of Pediatric
Pulmonology recertification - 2016
b) Licensure
Texas 1983 #G4865 (permanent)
Arizona 1989 #18866 (permanent)
Colorado 2016 #DR.0056313 (permanent)
Honors
1983 Merck Award for Clinical Excellence, University of Texas Health Science Center at Houston
1983 Ross Award for Excellence in Pediatrics, Department of Pediatrics, University of Texas Health Science Center at Houston
1984&1985 Outstanding Teacher Award, Department of Pediatrics, University of Oklahoma College of Medicine
1993 McLemore Birdsong Award for Excellence in Teaching, Department of Pediatrics, University of Virginia Health Sciences Center
2003 Outstanding Subspecialty Teaching Award, Department of Pediatrics,
University of Arizona
2005 Chairman’s Award, American Lung Association of Arizona
2013 Community Action Award, American Lung Association of Arizona
2015 Recognition of Quality Award, Chapter Quality Network Asthma Project Phase
4, American Academy of Pediatrics
2016 American Lung Association National Volunteer Excellence Award
2018 4-Star Excellence Award, Patient-Family Experience, Children’s Hospital Colorado
Professional Affiliations
1987-present American Thoracic Society
1996-2004 Pediatric Pulmonary Training Directors Association
2012-present European Respiratory Society
2012-present Wilderness Medical Society
2014-present American Academy of Pediatrics
Teaching Activities
1995- 2003, Director, Pediatric Pulmonary Fellowship Program, University of Arizona
2006-2011
2000 – 2016 Director, Tucson Pediatric Pulmonary Center for Leadership Education, University of Arizona
2003- 2016 Co-Director, Arizona Clinical Research Training Program, University of Arizona
Classroom Teaching:
1999-2005 Lecturer (2 hours) and Clinical Preceptor, Genetics 581, University of Arizona, College of Medicine
1998 – 2008 Lecturer (2 hours), PhPR 4750 (Pharmacy Practice), University of Arizona, College of Pharmacy
2005 Lecturer (2 hours), Nursing 612 (Advanced Practice Pediatrics)
University of Arizona, College of Nursing
2007 – 2016 Lecturer (1 hour/semester), PSIO 420/520 (Exercise and Environmental Physiology), University of Arizona
2008 – 2016 Lecturer (2 hours), Med 618/818 (Cardiovascular, Pulmonary Renal System), University of Arizona
2009 Lecturer (1.5 hours), PHCL501b (Pharmacological Basis of Therapeutics), University of Arizona
2011 – 2016 Lecturer (1.25 hours/semester), PSIO 450 (Respiratory Physiology), University of Arizona
2011 – 2014 Mock Study Section Reviewer, CPH/EPI 652, Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona
2015 Lecturer (1.5 hours), CHS 306 (Interprofessional Care – School of Sociology), University of Arizona
Invited Lectures (Past Ten Years)
January 23, 2010 “Cystic Fibrosis in Schools”, 2nd Annual Pediatric Health Care Issues in Schools Conference, Pediatric Pulmonary Center, Tucson, Arizona
April 6, 2010 “All-Event Emergency Preparedness for Children and Youth with Special Health Care Needs”, Pediatric Residents’ Conference, St. Joseph’s Medical Center, Phoenix, Arizona
April 9, 2010 “Asthma in Schools”, Cochise County School Nurses’ Conference, Sierra
Vista, Arizona
April 24, 2010 “Life Influences on Asthma Risk”, Fifth Annual Arizona Asthma
Conference, Arizona Asthma Coalition, Tucson, Arizona
November 2, 2010 “Look Back, Look Forward, Look Within: Using Financial Data to Manage Conflict in Academic Medicine”, Learning to Lead (Faculty Leadership Program), University of Arizona College of Medicine
September 10, 2011 “Dying to Learn, Dying to Breathe: Asthma in Schools”, 3rd Annual Pediatric Health Care Issues in Schools Conference, Pediatric Pulmonary Center, Arizona Grand Resort, Phoenix, Arizona
January 14, 2012 “Why is Asthma Increasing? Are we Too Clean a Society?”, Arizona Developmental Disability Nurses Association, Tucson, Arizona
June 23, 2012 “Bronchiolitis Guidelines: Emphasis on ‘Guide’ ”, 35th Annual Pediatrics in the Red Rocks Conference, Arizona Chapter, American Academy of Pediatric, Sedona, Arizona
June 24, 2012 “Breathless in Sedona: Treating Asthma in Kids”, 35th Annual Pediatrics in the Red Rocks Conference, Arizona Chapter, American Academy of Pediatric, Sedona, Arizona
January 26, 2013 “Applying Asthma Clinical Guidelines”, Arizona Chapter – American Academy of Pediatrics Asthma Learning Collaborative, Phoenix, Arizona.
May 30, 2013 “Is It Asthma? Or Are They Just Out of Shape?”, Leadership in Exercise and Health Conference, University of Arizona
June 29, 2013 “Asthma and Fatal Asthma”, 5th Annual School Health Conference, Pediatric Pulmonary Center, Pediatric Pulmonary Center, Arizona Grand Resort, Phoenix, Arizona
August 28, 2013 “Asthma and Fatal Asthma”, School Health Training Day, Sunnyside Independent School District, Tucson, AZ
October 26, 2013 “Health Disparities: Opportunities to Improve Asthma Outcomes in Arizona”, Keynote Address, Arizona Asthma Coalition Annual Asthma Conference, Mesa, Arizona
November 2, 2013 “Spirometry and Asthma”, Arizona Chapter – American Academy of Pediatrics Asthma Learning Collaborative, Phoenix, Arizona.
February 8, 2014 “Fostering Chronic Disease Self-Management: An Asthma Model”, 6th Annual School Health Conference, Pediatric Pulmonary Center, Pediatric Pulmonary Center, University of Arizona, Tucson, Arizona
June 14, 2014 “Fostering Chronic Disease Self-Management: An Asthma Model“, DHHS Region IX School Health Conference, San Diego, California
July 16, 2014 “Fostering Chronic Disease Self-Management: An Asthma Model” Arizona School Nurse Consortium Annual Conference, Phoenix, Arizona
September 19, 2014 “Acute Asthma Exasperation: Treating Asthma Exacerbations”, Providence St. Vincent Pediatric Fall Conference, Portland, Oregon
September 19, 2014 “Chronic Asthma Exasperation: Trying to make the Guidelines Work”, Providence St. Vincent Pediatric Fall Conference, Portland, Oregon
September 20, 2014 “Why Follow the Asthma Guidelines”, Arizona Asthma Coalition Annual Asthma Conference, Tempe, Arizona
November 6, 2014 “2014 AAP Bronchiolitis Guidelines: Less of the Same”, University of Arizona Pediatric Grand Rounds
December 13 2014 “Why Follow the Asthma Guidelines”, American Academy of Pediatrics Chapter Quality Network Asthma Learning Collaborative, Elk Grove, Illinois
January 31, 2015 “Applying the Asthma Clinical Guidelines”, Chapter Quality Network 4, Georgia Chapter, American Academy of Pediatrics, Atlanta, Georgia
February 7, 2015 “Applying the Asthma Clinical Guidelines”, Chapter Quality Network 4, California Chapter 4, American Academy of Pediatrics, Irvine, California
February 19, 2015 “2014 AAP Bronchiolitis Guidelines: Less of the Same”, Pediatric Conference, Yuma Regional Medical Center, Yuma, Arizona (Teleconference)
February 21, 2015 “Fostering Chronic Disease Self-Management: An Asthma Model”, 7th Annual School Health Conference, Pediatric Pulmonary Center, Pediatric Pulmonary Center, University of Arizona, Phoenix, Arizona
April 14, 2015 “Chronic Asthma Exasperation: Overcoming Barriers to Good Asthma Control”, Pediatric Grand Rounds, University of California San Francisco Benioff Children’s Hospital, Oakland, California
May 15, 2015 “Severe Asthma in Children - Definitions and Treatment Options”, American Thoracic Society Fellows Track Symposium, Denver, Colorado
July 25, 2015 “Spirometry and Asthma”, Chapter Quality Network 4, California Chapter 4, American Academy of Pediatrics, Irvine, California
November 4, 2015 “Severe Asthma in Children - Definitions and Treatment Options”, Pediatric Pulmonary Conference, University of Colorado/Childrens Hospital of Colorado, Denver, Colorado
November 6, 2015 “2014 AAP Bronchiolitis Guidelines: Less of the Same”, Pediatric Grand Rounds, Loma Linda University, Redlands, California
November 6, 2015 “Why Follow the Asthma Guidelines?”, Pediatric Residents’ Conference, Loma Linda University, Redlands, California
November 19, 2015 “Adjunctive Therapies in Status Asthmaticus”, 7° Congreso Argentino de Neumonología Pediátrica, Mar del Pata, Argentina
November 19, 2015 “School-Based Asthma Therapy”, 7° Congreso Argentino de Neumonología Pediátrica, Mar del Pata, Argentina
November 20, 2015 “Reducing Asthma Hospitalizations”, 7° Congreso Argentino de Neumonología Pediátrica, Mar del Pata, Argentina
November 20, 2015 “Core Competencies in Pediatric Pulmonology Fellowship Training”, 7° Congreso Argentino de Neumonología Pediátrica, Mar del Plata, Argentina
January 20, 2016 “Pulmonary Jeopardy”, Pediatric Residents’ Conference, University of Arizona, Tucson, Arizona
January 30, 2016 “2014 AAP Bronchiolitis Guidelines: Less of the Same”, Telluride Mid-Winter Conference on Women’s and Children’s Healthcare, Telluride, Colorado
January 31, 2016 “Chronic Asthma Exasperation: Overcoming Barriers to Good Control”, Telluride Mid-Winter Conference on Women’s and Children’s Healthcare, Telluride, Colorado
March 5, 2016 “Asthma, Anaphylaxis and Cystic Fibrosis in the Educational Setting”, California School Nurses Organization – Northern Chapter Annual Meeting, Sacramento, CA
April 23, 2016 “Fostering Chronic Disease Self-Management: An Asthma Model”, California School Nurses Organization – Bay Coast Chapter Annual Meeting, Mountain View, CA
August 25, 2016 “Is COPD a Pediatric Disorder?”, VII Curso Internacional de Pediatría UC 2016, Pontifica Universidad Católica De Chile, Santiago, Chile
August 26, 2016 “Management of Complications of Community Acquired Pneumonia”, VII Curso Internacional de Pediatría UC 2016, Pontifica Universidad Católica De Chile, Santiago, Chile
August 27, 2016 “The Diagnosis and Treatment of Asthma in Preschool Children”, VII Curso Internacional de Pediatría UC 2016, Pontifica Universidad Católica De Chile, Santiago, Chile
May 23, 2018 “PRO: Bronchodilators, Steroids and Oxygen Should Not Be Given in Viral Bronchiolitis”, American Thoracic Society International Conference on Lung Health, San Diego, CA
August 15, 2018 “Challenging the Airway”, Pulmonary Grand Rounds, Children’s Hospital Colorado, Aurora, CO
October 2, 2018 “Management of the Hospitalized Child with Asthma: Beyond Albuterol and Steroids”, UCHealth Pediatric Grand Rounds, Poudre Valley Hospital, Ft. Collins, CO
November 9, 2018 “Problematic Severe Asthma in Children: Definitions and Treatment Options”, Pediatric Grand Rounds, Loma Linda University School of Medicine, Loma Linda, CA
November 9, 2018 “Bronchiolitis”, Pediatric Resident Conference, Loma Linda University School of Medicine, Loma Linda, CA
Professional Activities
Officer: Secretary-Treasurer, Pediatric Pulmonary Training Director’s Association, 1998-2004
Peer Reviewer: American Journal of Epidemiology
American Journal of Public Health
American Journal of Respiratory and Critical Care Medicine
Clinical and Experimental Allergy
European Respiratory Journal
Journal of the American Medical Association
Journal of Asthma
Journal of Medical Genetics
Journal of Pediatrics
New England Journal of Medicine
Nutrition Reviews
Pediatric Allergy and Immunology
Pediatric Infectious Disease Journal
Pediatric Pulmonology
Pediatrics
Expert Review of Respiratory Medicine
Editorial Board: Journal of Asthma (2014-2018)
Grant Reviewer: Canadian Cystic Fibrosis Foundation
March of Dimes
National Institute of Allergy and Infectious Diseases (2012, 2016)
Promotion Reviewer: University of Arizona Department of Physiology
External Promotion Reviewer:
University of Wisconsin-Madison
University of Utah
University of Virginia
University of Alabama – Birmingham
Baylor College of Medicine
Stanford University
University of Missouri
Creighton University
Consultant: Arizona Health Care Containment System, Committee on Technology Assessment and Medical Necessity, November 1998; October 1999
University Health Systems Consortium
Asthma Clinical Benchmarking Coordinating Committee, 2000
McKesson Health Systems, 2014-2015
AstraZeneca, Windward Data Safety Monitoring Board, 2014-2018
Cystic Fibrosis Foundation Therapeutics Data Safety Monitoring Board, 2015 - ongoing
Faculty Advisor: Medical Student
Pediatric Resident
Arizona Clinical Research Training Program Scholars
Clinical Activities
Inpatient: Attending Physician Four weeks per year
Inpatient Pulmonary Service
Attending Physician Four weeks per year
Pulmonary Consult Service
Attending Physician Four weeks per year
NICU Pulmonary Consult Service
Outpatient: Attending Physician Twelve months per year
Pediatric Pulmonary Clinic
12 hours/week
Attending Physician/Co-Director Twelve months per year
Multi-Disciplinary Asthma Clinic
8 hours/month
Committees (Past Ten Years)
Local:
2016 – Ongoing Code Committee, Children’s Hospital Colorado
2017 – Ongoing Asthma Population Health Committee, Children’s Hospital Colorado
2019 – Ongoing Respiratory Care Practice Council, Children’s Hospital Colorado
Current Area of Research Interest
School-based Asthma Management
Pulmonary Function Testing in Trisomy 21
Previous Grant Awards:
T72MC00012 (Brown) PI 07/01/10 - 06/30/15
HRSA/MCHB $1,725,000
20% effort
“Tucson Pediatric Pulmonary Training Center”
ALA-ACRC (Gerald) Co-Investigator 01/01/00 - 06/30/18
American Lung Association $75,000/year
2% effort
“American Lung Association Asthma Clinical Research Center”
1R18HL110858 (Gerald) Co-Investigator 08/10/13-04/30/17
NIH/NHLBI $3,155,975
4% effort
“The Cost-Effectiveness of School-Based Supervised Asthma Therapy.”
Individual National Research Service Award (NHLBI), “Aerosolized Endotoxin and Lung Injury in Rabbits”, 1988-90; $63,000.
Arizona Elks Comprehensive Program and Transplantation Research Grant, “Early Human T-helper Cell Differentiation,” 1996-1997; $14,984.
Dean’s Physician-Scientist Career Development Award, University of Arizona College of Medicine; 1997-99; $87,500.
Arizona Disease Control Research Commission, “The Effect of Tobacco and Its Constituents on Placental Development, Differentiation and Function,” 1998-2001; $354,477.
AstraZeneca, “A Safety and Efficacy Study of Two Dosage Levels of Pulmicort® RespulesTM (budesonide inhalation suspension, 0.5 or 1.0 mg/day) versus Placebo in Infants Between the Ages of Six and Twelve Months with Mild to Moderate Asthma”, 2000-2001; $15,000.
Cystic Fibrosis Foundation, “A Multicenter, Randomized, Placebo-Controlled, Double-Blinded Trial of Azithromycin in Patients with CF, Chronically Infected with Pseudomonas aeruginosa”, 2000-2001; $28,015
Mentored Clinical Scientist Development Award (KO8-NIAID), “Maternal Influences on Early Human T-Cell Differentiation,” 1998-2003; $397,710.
Boerhinger Ingelheim Pharmaceuticals, Inc. "A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of 24 Weeks of Oral Treatment with BIIL 284 BS in Adult (75 mg, 150 mg) and Pediatric (75 mg) Cystic Fibrosis Patients," 2003-2004; $108,352.
Genentech, Inc. "A Study to Determine the Variability of a 6-Minute Walk Test in Cystic Fibrosis Subjects with Advanced Lung Disease", 2003-2004; $4,626
University of Utah/Cystic Fibrosis Foundation. “Improving Performance in the Detection and Management of CFRD”, 2003-2006. $7,500.
Genentech, Inc. "Epidemiologic Study of Cystic Fibrosis: A Multicenter, Longitudinal Follow-up Study of Patients with Cystic Fibrosis for Monitoring Pulmonary Function, Pulmonary Exacerbations, and the Safety of Long-Term Treatment with Pulmozyme (dornase alfa)", 2003-2005, $20,000.
ALA-AZ/NM, “Maternal Influences on Early Human T-cell Differentiation”, 2002-2005, $150,000.
GlaxoSmithKline, “Diagnosis of EIB and Asthma in NCAA Division I Athletes”, 2005-2008,
$15,180.
NIH/NHLBI RO1-HL-080083 (Martinez) Co-Inv. “Asthma Exacerbations: Biology and Disease Progression”, 2005-2009, $2,111,813.
GlaxoSmithKline, “VESTRI: A 6-month Safety and Benefit Study of Inhaled Fluticasone Propionate/Salmeterol Combination Versus Inhaled Fluticasone Propionate in the Treatment of 6,200 Pediatric Subjects 4-11 Years Old with Persistent Asthma”, 2013 – 2015, $36,171.
Fellows Supervised
Christine Chiaviello, MD 1993 - 1995
Pediatric Emergency Medicine Fellow
University of Virginia
Isabelle Jacques, MD 1994 - 1995
Pediatric Pulmonary Clinical
Research Fellow
University of Virginia
Autumn Clos, MD 1995 – 1998
Pediatric Pulmonary Fellow
University of Arizona
Ali Özdemir, MD 1996 - 1998
Pediatric Pulmonary Clinical
Research Fellow
University of Arizona
Maria Martinez, MD 1996 – 1999
Pediatric Pulmonary Fellow
University of Arizona
Fazilet Karakoç, MD 1998 – 2000
Pediatric Pulmonary Fellow
University of Arizona
Francesca Marotti, MD 1998 –2001
Pediatric Pulmonary Fellow
University of Arizona
Edward Fong, MD 2001-2004
Pediatric Pulmonary Fellow
University of Arizona
Kimberly Otsuka, MD 2002-2008
Pediatric Pulmonary Fellow
University of Arizona
Esmeralda Morales, MD 2003-2007
Pediatric Pulmonary Fellow
University of Arizona
Dima Ezmigna, MBBS 2009-2012
Pediatric Pulmonary Fellow
University of Arizona
Anunya Hiranrattana, MD 2012-2015
Pediatric Pulmonary Fellow
University of Arizona
Ali Assiri, MD 2014-2016
Pediatric Pulmonary Fellow
University of Arizona
Nasim Khattab, MD 2016
Pediatric Pulmonary Fellow
University of Arizona
Monica Vielkind, MD 2017-2020
Pediatric Pulmonary Fellow
University of Colorado
Students Supervised
Parmis Rad 1998-2000
Undergraduate Biology Research Program
University of Arizona
Samira Ehteshami 2000 – 2003
Undergraduate Biology Research Program
University of Arizona
Valerie Miranda 2003
Medical Student Summer Research Program
University of Arizona
Autumn Sky Watson 2003-2004
Minority Access to Research Careers (MARC) Program
University of Arizona
Diana Olivas 2004-2005
Undergraduate Biology Research Program
University of Arizona
Giselle Celaya 2005
NIH Disadvantaged High School Student
Research Program
University of Arizona
Publications
Peer Reviewed Articles:
1. Bittner GD, Brown MA. Long term survival of enucleated segments of glial cytoplasm in the leech, Macrobdella decora. Brain Research 1981;218:357-364.
2. Reyes de la Rocha S, Brown MA. Asthma in children: emergency management. Annals of Emergency Medicine 1987;16:79-89.
3. Reyes de la Rocha S, Brown MA, Fortenberry JD. Pulmonary function abnormalities in chronic paint inhalation. Chest 1987;92:100-104.
4. Reyes de la Rocha S, Brown MA. Normal pulmonary function after baby powder inhalation causing adult respiratory distress syndrome. Pediatric Emergency Care 1989;5:43-48.
5. Brown MA, Morgan WJ, Finley PR, Scuderi P. Circulating levels of tumor necrosis factor and interleukin 1 in cystic fibrosis. Pediatric Pulmonology 1991;10:86-91.
6. Brown MA, Lantz RC, Sobonya R, Devine LC, Lentz LA, Lemen RJ. Aerosolized lipopolysaccharide increases pulmonary clearance of Tc-DTPA in rabbits. American Review of Respiratory Disease 1992;146:1462-1468.
7. Özdemir A, Brown MA, Morgan WJ. Markers and mediators of inflammation in neonatal lung disease. Pediatric Pulmonology 1997;23:292-306.
8. Halonen M, Stern D, Lohman IC, Wright AW, Brown MA, Martinez F. Two subphenotypes of childhood asthma that differ in maternal and paternal influences on asthma risk. Am J Respir Crit Care Med 1999;160:564-570.
9. Brown MA, Rad PY, Halonen M. Method of birth alters interferon-gamma and IL-12 production by cord blood mononuclear cells. Ped Allergy Immunol 2003;14:106-111.
10. Brown M, Gustafson M, Saldaña S, Baradaran A, Miller H, Halonen M. Correlation of human decidual and cord blood mononuclear cell cytokine production. Hum Immunol 2004; 65:1336-1343.
11. American Academy of Pediatrics, Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and Management of Bronchiolitis. Pediatrics 2006; 118:1774-1793.
12. Hull SC, Sharp RR, Botkin JR, Brown MA, Hughes M, Sugarman J, Schwinn D, Sankar P, Bolcic-Jankovic D, Clarridge BR, Wilfond BS. Patients' views on identifiability of samples and informed consent for genetic research. Am J Bioethics 2008; 8:62-70.
13. Thorn ST, Brown MA, Yanes JJ, Sherrill DL, Pugmire J, Anderson KA, Klotz SA. Pulmonary nocardiosis in cystic fibrosis. J Cystic Fibrosis 2009; 8:316-320.
14. Gruchalla RS, Sampson HA, Matsui E, David G, Gergen PJ, Calatroni A, Brown MA, Liu AH, Bloomberg GR, Chmiel JF, Kumar R, Lamm C, Smartt E, Sorkness CA, Steinbach SF, Stone KD, Szefler, SJ, Busse WW. Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence. J Allergy Clin Immunol 2009; 124:213-221.
15. Millward D, Paul S, Brown M, Porter D, Stilson M, Cohen R, Olvey E, Hagan J. The diagnosis of asthma and exercised induced bronchospasm in Division I athletes. Clin J Sports Med 2009; 19:482-486.
16. Maykut R, Zeiger RS, Brown MA. Asthma in pediatric patients: unmet needs and
therapeutic options. Clin Pediatr 2010; 49:915-930.
17. Millward D, Tanner L, Brown MA. Treatment Options for the Management of Exercise Induced Asthma and Bronchospasm. Phys Sports Med 2010; 38(4):74-80.
18. Ezmigna D, Witte M, Morgan WJ, Brown MA. Lymphscintigraphy in plastic bronchitis: a pediatric case report. Pediatric Pulmonology 2012; 48(5):515-518.
19. Parikh K, Witte M, Samson R, Teodori M, Carpenter J, Lowe MC, Morgan W, Hardin C,
Brown M, Naughton Y, Sinha S, Barber BJ. Successful palliation of plastic bronchitis with
non-fat diet and ultimate treatment with thoracic duct ligation in patient with Fontan
physiology. Lymphology 2012; 45:47-52.
20. Committee on Infectious Diseases and Bronchiolitis Guidelines Committee, American
Academy of Pediatrics. Updated guidance for palivizumab prophylaxis among infants and
young children at increased risk of hospitalization for respiratory syncytial virus
infection. Pediatrics 2014;134:415-420.
21. Committee on Infectious Diseases and Bronchiolitis Guidelines Committee, American
Academy of Pediatrics. Technical report: updated guidance for palivizumab prophylaxis
among infants and young children at increased risk of hospitalization for respiratory
syncytial virus infection. Pediatrics 2014;134:e620–e638.
22. Subcommittee on the Diagnosis and Management of Bronchiolitis, American Academy of
Pediatrics. Clinical Practice Guideline: Diagnosis and management of bronchiolitis.
Pediatrics 2014; 118:1774-1793.
23. Hasegawa K, Ahn J, Brown MA, Press VG, Gabriel S, Herrera V, Bittner JC, Camargo CA Jr., on behalf of the MARC-37 Investigators. Underutilization of guideline-recommended chronic asthma management in children hospitalized to the intensive care unit: A multicenter observational study. Ann Allergy Asthma Immunol 2015; 115(1):10-16.
24. Hasegawa K, Bittner JC, Nonas SA, Stoll SJ, Watase T, Gabriel S, Herrera V, Camargo CA Jr. on behalf of the MARC-37 Investigators. Children and Adults with Frequent Hospitalizations for Asthma Exacerbation, 2012-2013: A Multicenter Observational Study. J Allergy Clin Immunol Pract 2015; 3:751-758.
25. O’Brien KL, Chandran A, Weatherholtz R, Jafri HS, Griffin P, Bellamy T, Millar EV, Hensen KM, Harris BS, Reid R, Moulton LH, Losonsky GA, Karron RA, Santosham M, for the RSV Prevention Study Group. Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy American Indian infants: a phase 3 randomized double-blind trial. Lancet Infect Dis 2015; 15:1398-1408.
26. Wisniewski JA, McLaughlin AP, Stenger PJ, Patrie J, Brown MA, El-Dahr JM, Platts-Mills TAE, Heymann PW. A comparison of seasonal trends in asthma exacerbations among children from geographic regions with different climates. Allergy Asthma Proc 2016; 37:475-481.
27. Liou T, Jensen J, Brayshaw S, Brown M, Chatfield B, McDonald C, Koenig J, Peet K, Radford P, Reineke K, Otsuka K, Wagener J, Young D, Marshall B. Improving performance in the detextion and management of cystic fibrosis related diabetes in the Mountain West CF Consortium. BMJ Open Diab Res Care 2016; 4:e000183 doi:1-.1136/bmjdrc-2015-000183.
28. Gerald LB, Snyder A, Disney J, Gerald JK, Thomas A, Wilcox, G, Brown, MA. Implementation and evaluation of a stock albuterol program for students with asthma. Annals Am Thorac Soc 2016; 13:295-296.
29. DiMango E, Rogers L, Reibman J, Gerald LB, Brown M, Sugar EA, Henderson R,
Holbrook JT. Risk factors for asthma exacerbation and treatment failure in adults and
adolescents with well-controlled asthma during continuation and step-down therapy. Annals
Am Thorac Soc 2018; 15:955-961.
30. Krishnan S, Dozor A, Bacharier L, Lang J, Irvin C, Kaminsky D, Farber H, Gerald Lynn, Brown M, Holbrook J, Sugar E, Yasin R, Saams J, Henderson R, Ryu J, Bose S, Teague WG, Bailey W, Wise R. Clinical characterization of children with resistant airflow obstruction, a multicenter study. J Asthma 2019; 56(6):611-617.
31. Gerald JK, Fisher J, Brown MA, Clemens C, Moore M, Carvajal S, Bryson D, Stefan N, Billheimer D, Gerald LB. School-supervised use of a once-daily inhaled corticosteroid regimen: a cluster randomized trial. J Allergy Clin Immunol 2019; 143(2):755-764.
32. Brown, MA. Bronchodilators and Steroids Should Not Be Given in Viral Bronchiolitis -
PRO. Paediatr Respir Rev (in press).
Invited Reviews/Editorials:
1. Brown MA, Taussig LM: Fertility, birth control and pregnancy in adult patients with cystic fibrosis. Pulmonary Perspectives 1988;5:1-3.
2. Swanson C, Brown MA. Understanding children with chronic lung disease. Part I: Lung function. Infants and Young Children 1992;5:68-77.
3. Brown MA, Swanson C. Understanding children with chronic lung disease. Part II: Respiratory supports and treatments. Infants and Young Children 1993;5:57-66.
4. Brown MA, Halonen M, Martinez FD. Cutting the cord: Is birth already too late for primary prevention of allergy? Clin Exper Allergy 1997;27:4-6.
5. Brown MA, Halonen M. Perinatal events in the development of asthma. Curr Opin Pulm Med 1999;5:4-9.
6. Brown MA, Halonen M. Fetal and neonatal events in the development of allergy. Can J Allergy Clin Immunol 2000;5:70-74, 79.
7. Fortkamp E, Brown MA. Corticoesteróides inhalatórios e c(escimento - uma revisão. (Inhaled corticosteroids and growth – a review). Jornal de Pediatria 2000;76:263-274.
8. Brown MA, Capen C, Morgan WJ. Working together to save lives: Pediatric Pulmonary Centers provide an effective model for interdisciplinary care. Advance for Managers of Respiratory Care 2005; April: 42-44.
9. Brown, MA. A Tough Nut to Crack. J Pediatr 2008; 152:749-750.
10. Phan H, Brown MA. Fluticasone furoate for the treatment of childhood asthma. Expert Rev Respir Med 2015; 9:391-404.
Book Chapters:
1. Brown MA, Lemen RJ: Bronchiectasis. In: Kendig EL, Chernick V, eds. Disorders of the Respiratory Tract in Children (5th ed). Philadelphia: WB Saunders Co., 1983, pages 416-428.
2. Brown MA, Pneumonia. In: McGahren E, Wilson W, eds. Pediatric Recall. Baltimore: Williams & Wilkins Co., 1997, pages 203-205.
3. Brown MA, Emphysema. In: McGahren E, Wilson W, eds. Pediatric Recall. Baltimore: Williams & Wilkins Co., 1997, pages 201-202.
4. Brown MA, Lemen RJ: Bronchiectasis. In: Kendig EL, Chernick V, eds. Disorders of the Respiratory Tract in Children (6th ed). Philadelphia: WB Saunders Co., 1998, pages 538-552.
5. Brown MA, Morgan WJ. Clinical Assessment and Diagnostic Approach to Common Problems. In: Taussig LM, Landou L, eds. Pediatric Respiratory Medicine. St. Louis: Mosby-Year Book, Inc., 1999, pages 136-151.
6. Brown MA, von Mutius E, Morgan WJ. Clinical Assessment and Diagnostic Approach to Common Problems. In: Taussig LM, Landou L, eds. Pediatric Respiratory Medicine(2nd ed.). St. Louis: Mosby-Year Book, Inc., 2008, pages 107-134.
7. Brown MA. Pulmonary Nodules. In: McMillan, Barrett, Boney, Jones, eds. Clinical Decision Support: Pediatrics.
Abstracts:
1. Brown MA, Scuderi P, Sobonya RE, Lemen RJ. Aerosolized endotoxin alters pulmonary clearance of Tc-DTPA in rabbits. American Review Respiratory Disease 1990;141:A916.
2. Lantz RC, Brown MA, Grad R, Lemen RJ. Correlation of oxygen radical production and epithelial permeability changes following inhalation of Pseudomonas lipopolysaccharide (LPS). American Review Respiratory Disease 1990;141:A916.
3. Lantz RC, Grad R, Sobonya R, Brown MA, Quan S, Lemen RJ. Superoxide release corresponds with resolution of adenovirus induced airway hyperresponsiveness. American Review Respiratory Disease 1990;141:A689.
4. Halonen M, Stern DA, Brown MA, Wright A, Holberg CJ, Martinez FD. Influence of maternal allergic disease during pregnancy on IgE, Alternaria skin tests and asthma in children. Am J Respir Crit Care Med 1997;155:A250.
5. Raman K, Brown MA, Halonen M. Relation between skin test reactivity and presence of T-helper cells of the CD4+CD45RA+ phenotype. J Allergy Clin Immunol 1997:99:S298.
6. Rider ED, Özdemir A, Brown MA, Sherrill DL. Predictive value of score for neonatal acute physiology in bronchopulmonary dysplasia in infants ( 1500 grams. Am J Respir Crit Care Med 1998;157:A375.
7. Brown MA, Chun A, Lohman IC, Roman K, Hensel JL, Dudley D, Halonen M. Human decidual cells produce both TH1-like and TH2-like cytokines in vitro. Am J Respir Crit Care Med 1998;157:A395.
8. Rad PY, Chun A, Halonen M, Brown MA. Influence of labor on cytokine production by activated cord blood mononuclear cells. Am J Respir Crit Care Med 1999;159:A103.
9. Miller HS, Gustafson M, Baradaran A, Saldana S, Brown M. IL-4 production is increased in placentas obtained from pregnant smokers. J Soc Gynecol Investig 2000;7 (suppl) 286A.
10. Brown MA, Gustafson M, Saldana S, Miller H, Halonen M. Increased capacity of decidua from allergic women to produce IL-4. Am J Respir Crit Care Med 2000;161:A599.
11. Clark S, Brown MA, Camargo CA. Management of pediatric asthma in US hospitals. The UHC Asthma Benchmarking Project. Am J Respir Crit Care Med 2001; 166:A542.
12. Gustafson MR, Ehteshani S, Saldana S, Brown MA, Miller HS. Analysis of the validity of self-reported smoking status among pregnant women. J Soc Gynecol Invest 2002; 9:286A.
13. Brown MA, Gustafson MR, Saldana S, Ehteshani S, Miller HS. Maternal smoking and allergy are associated with increased decidual IL-4 production. J Soc Gynecol Investig 2002; 9:232A.
14. Brown MA, Gustafson M, Saldana S, Beradaran A, Miller H, Halonen M. Relationship between decidual and cord blood mononuclear cell cytokine production: effect of maternal smoking and allergy. Am J Respir Crit Care Med 2002; 165:B46.
15. McLaughlin AP, Brown MA, Hillman DG, Brice D, Heymann PW. Emergency department visits for children with asthma exacerbations living in locations with different climates. J Allergy Clin Immunol 2005; 115:S170.
16. Brown MA, Ehteshami S, Gustafson MR, Saldana SS, Miller HS, Halonen M. Maternal allergy status alters age-associated changes in human decidual soluble CD14 production. Am J Respir Crit Care Med 2007; 175:A680.
17. Ehteshami S, Gustafson MR, Saldana SS, Miller HS, Brown MA. Validity of self-reported tobacco exposure among pregnant women donating tissue for research studies. Am J Respir Crit Care Med 2007; 175;A599.
18. Hagan J, Millward D, Paul S, Brown M, Olvey E, Cohen R, Porter D, Stilson M. The diagnosis of exercise induced bronchospasm and asthma in NCAA Division I athletes. Clin J Sport Medicine 2008; 18(2):186.
19. Ehteshami S, Brown MA, Graves PE, Martinez FD. Genetics of neutrophilic asthma exacerbation in children: role of IL-8. Am J Respir Crit Care Med 2008; 177:A774.
20. Ehteshami S, Brown MA, Stern DA, Goodwin JL, Martinez FD. Increased sputum YKL-40 during acute asthma exacerbations in children. Am J Respir Crit Care Med 2009; 107: A2512.
21. Brown MA, Ehteshami S, Lohman C, Morgan WJ, Spangenberg A, Goodwin JL, Vercelli D, Halonen M, Martinez FD. Patterns of sputum cellularity and IL-6 and IL-13 expression in exacerbation of childhood asthma. Am J Respir Crit Care Med 2009; 107: A3922.
22. Griscti K, Maykut RJ, Massanari M, Camargo Jr. CA, Szefler SJ, Brown MA , Sorkness C,
Kianifard F, Zeldin RK. Baseline characteristics of children with symptomatic, moderate-to-severe allergic asthma – the BUS study. American College of Chest Physicians, 2009.
23. Griscti KD, Kianifard F, Figliomeni M, Inhaber N, Brown MA, Camargo, Jr. CA, Szefler
SJ, Zeldin RK. Baseline allergic co-morbidities and aeroallergen sensitivities in an
observational study of children with moderate-to-severe inadequately controlled allergic
asthma - the BUS study. AAAAI 2010, New Orleans, LA.
24. Ezmigna D, Witte M, Morgan WJ, Brown MA. Lymphscintigraphy in plastic bronchitis:
a pediatric case report. American Thoracic Society 2011, Denver, CO.
25. Ezmigna D, Brown M, Daines C, Morgan W. Bronchoalveolar lavage cell profiles in uncontrolled wheezy children with negative or positive asthma predictive indices. American Thoracic Society 2012, San Francisco, CA.
33. Brown MA, Stern DA, Lohman IC, Halonen M, Ehteshami S, Vercelli D, Martinez FD.
Sputum IL-13 is associated with paucigranulocytic asthma exacerbations in children.
American Thoracic Society 2013, Philadelphia, PA.
34. Gerald J, Brown M, Clemens C, Jenkins I, Billheimer D, Goodwin J, Johnson D, Bryson
D, Snyder A, Gerald L. Association between BMI and baseline demographic and clinical
characteristics among Hispanic children with asthma. American Thoracic Society 2015,
Denver, CO.
30. Lowe AA, Gerald JK, Clemens C, Brown MA, Moore M, Carr TF, Goforth M, Fisher J, Billheimer D, Gerald LB. Mobile telemedicine programs in school could increase clinician efficiency and improve access to health care among children with asthma. (Oral Presentation) American Thoracic Society International Conference 2015. San Francisco, California.
31. Oren E, Combs D, Fisher J, Goodwin JL, Billheimer D, Gerald JK, Clemens C, Brown M, Gerald LB. Impact of asthma control on sleep outcomes of elementary school children. American Thoracic Society International Conference 2015. San Francisco, California.
32. Gerald JK, Fisher J, Billheimer D, Brown MA, Clemens CJ, Moore MA, Gerald LB. Controller medication prescribing and adherence among Medicaid insured children. American Thoracic Society International Conference 2018. San Diego, California.
33. Deshpanda D, Phan H, Borgstrom M, Miller R, Brown M. Caregiver knowledge as a predictor of length of stay in children hospitalized with asthma exacerbations. American College of Asthma, Allergy and Immunology Conference 2018. Seattle, Washington.
Web-Based Educational Modules:
1. Brown MA, Gerald LB, Bruzzese J-M, Eakin MN. Challenges in Caring for the Child with
Asthma: Enlisting Community Services.
2. Pulmonary Nodules. Clinical Advisor, Decision Support in Medicine, Pediatrics. 2011
Short Communications:
Brown MA, Scuderi P, McIntosh JC, Pfeffer K, Parsons P. Relation between necrosis factor-alpha and granulocyte elastase-alpha-1 proteinase inhibitor complexes in the plasma of patients with cystic fibrosis (letter). American Review of Respiratory Disease 1990;142:984-985.
Gerald LB, Disney J, Gerald JK, Thomas A, Wilcox G, Brown MA. Implementation and evaluation of a stock albuterol program for students with asthma. Ann Am Thor Soc 2016; 13:295-296.
Community Activities
June 1996 Camp Physician/Medical Director, “Pimaree” (Joint Mexican-Arizonan Scout Camp), Boy Scouts of America, Old Sunnyside, Arizona
1996 – 2002 Volunteer Physician, Women’s & Children’s Clinic, Brewster Center for Abused Women
1998 - Ongoing Volunteer Camp Physician, Camp-Not-A-Wheeze, American Lung Association of Arizona, Prescott, Arizona
2004 – 2016 Medical Director, Camp-Not-A-Wheeze, American Lung Association of Arizona, Prescott, Arizona
2010 – 2016 Board of Directors, Arizona Asthma Coalition
2011 Vice Chair, Board of Directors, Arizona Asthma Coalition
2012 – 2016 Chair, Board of Directors, Arizona Asthma Coalition
2015 - 2016 Member, Chronic Lower Respiratory Disease Coalition Leadership Team, American Lung Association of Arizona
2016 Volunteer Camp Physician, CHAMP Camp, American Lung Association of Colorado
2018 – Ongoing Volunteer Camp Physician, Roundup River Ranch, Gypsum, CO
2019 – Ongoing Member, Medical Advisory Committee, Roundup River Ranch, Gypsum, CO
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