FRACP 2002 – Pharmacology
For a given maintenance dose rate, clearance is the sole parameter determining the steady state drug conc. ... UpToDate 11.2. ... or time dependent (-lactams, vancomycin), such that the reduction in bacterial density is proportional to the time that concentrations exceed the MIC. For concentration-dependent antibiotics, the Cmax/MIC or AUC/MIC ... ................
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