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Drugs with a narrow therapeutic index (e.g. vancomycin, lithium) require the greatest care in use (3). Some drugs known to be mainly excreted hepatically, with no toxic metabolites, e.g. carbamazepine, theophylline may be safe to use in full doses in all degrees of RI (3). However, as there is emerging data on the effect of CKD on drug metabolism ................
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