Vanguard UCITS Portfolios (Offshore) Vanguard Investment ...

Vanguard UCITS Portfolios (Offshore) Vanguard Investment Series plc

Period ending 31 March 2016

Vanguard Offshore portfolios -- At a glance

Vanguard fund

Index equity

Global Stock Index Fund Global Small-Cap Index Fund U.S. 500 Stock Index Fund European Stock Index Fund Eurozone Stock Index Fund Emerging Markets Stock Index Fund Japan Stock Index Fund Pacific ex-Japan Stock Index Fund SRI European Stock Fund SRI Global Stock Fund

Quantitative equity

Global Enhanced Equity Fund

Vanguard fund

Active equity

U.S. Discoveries Fund 1 U.S. Fundamental Value Fund U.S. Opportunities Fund 1

Benchmark

MSCI World Index MSCI World Small Cap Index S&P 500 Index MSCI Europe Index MSCI EMU Index MSCI Emerging Markets Index MSCI Japan Index MSCI Pacific ex Japan Index FTSE Developed Europe Index FTSE Developed Index

MSCI World Index

Manager

Granahan Investment Management Pzena Investment Management PRIMECAP Management Company

Vanguard fund

Fixed income

Benchmark

Global Bond Index Fund

Barclays Global Aggregate Float Adjusted Bond Index Hedged

U.S. Government Bond Index Fund

Barclays Global Aggregate U.S. Government Float Adjusted Bond Index

U.S. Investment Grade Credit Index Fund Barclays Global Aggregate U.S. Credit Float Adjusted Bond Index

Euro Government Bond Index Fund

Barclays Euro Government Float Adjusted Bond Index

Euro Investment Grade Bond Index Fund Barclays Euro Non-Government Float Adjusted Index

Total assets Ongoing charges figure (%) Purchase

USD (millions) Institutional

Investor

fee (%)

7,837

0.25

668

0.38

5,497

0.10

5,452

0.30

2,482

0.30

6,535

0.27

2,250

0.23

1,432

0.23

934

0.30

839

0.35

0.30

--

0.40

--

0.25

--

0.35

--

0.35

--

0.40

--

0.30

--

0.30

--

0.35

--

0.40

--

136

0.50

--

--

Total assets Ongoing charges figure (%) Purchase

USD (millions) Institutional

Investor

fee (%)

109

--

29

--

2,087

0.85

0.85

--

0.95

--

0.95

--

Total assets Ongoing charges figure (%) Purchase

USD (millions) Institutional

Investor

fee (%)

5,105

0.15

957

0.20

1,480

0.25

4,269

0.20

2,261

0.25

0.20

0.20

0.25

--

0.30

0.50

0.25

--

0.30

0.30

Minimum initial investment: $500,000 institutional share class; $100,000 investor share class. 1 Closed to new investors

FOR ACCREDITED AND INSTITUTIONAL INVESTOR AND FINANCIAL PROFESSIONAL USE ONLY. NOT FOR PUBLIC DISTRIBUTION.

Vanguard Offshore portfolios -- At a glance

Vanguard fund

Benchmark

Fixed income

Eurozone Inflation-Linked Bond Index Fund U.K. Investment Grade Bond Index Fund 1

Barclays Global Inflation -Linked: Eurozone - Euro CPI Index Barclays GBP Non-Government Float Adjusted Bond Index

20+ Year Euro Treasury Index Fund

Barclays Euro Treasury 20+ Year Index

Japan Government Bond Index Fund U.S. Ultra-Short-Term Bond Fund 2

Global Short-Term Bond Index Fund U.K. Government Bond Index Fund 3

U.K. Short-Term Investment Grade Bond Index Fund 3

Barclays Japan Government Float Adjusted Bond Index

BofA Merrill Lynch 6-month Treasury Bill Index Barclays Global Aggregate 1-5 Years ex US MBS Float Adjusted Bond Index

Barclays U.K. Government Float Adjusted Bond Index

Barclays Global Aggregate 500MM U.K. Non-Government 1-5Y Float Adjusted Bond Index

Ongoing charges

Total assets

figure (%)

Purchase

USD Institutional Investor fee (%)

1,264 0.20 2,135 0.06

824 0.25 604 0.20

91 0.25 839 0.15

1,529 0.06 1,340 0.05

0.25

--

0.15

0.50

--

--

0.25

--

0.30

--

0.20

0.20

0.15

--

0.15

0.30

Total returns (%)?Institutional USD shares

Vanguard fund (Inception date)

Benchmark Index equity Global Stock Index Fund (4 Aug 1998) MSCI World Index

1Q 2016

- 0.40 - 0.35

Average annual total returns 1 year 3 years 5 years 10 years

Since inception

- 3.63

6.63

6.28

4.02

4.25

- 3.45

6.82

6.51

4.27

4.44

Global Small-Cap Index Fund (10 Dec 2009) MSCI World Small Cap Index

0.64

- 4.17

6.78

6.11

0.67

- 3.91

7.05

6.38

--

10.23

--

10.53

U.S. 500 Stock Index Fund (4 Nov 1998) S&P 500 Index (with 70% of dividend) European Stock Index Fund (14 Sep 1998) MSCI Europe Index Eurozone Stock Index Fund (27 Feb 2014) MSCI EMU Index Emerging Markets Stock Index Fund (27 Feb 2014)

1.16 1.18 - 2.54 - 2.51 - 2.11 - 2.09 5.59

1.09 1.12 - 8.42 - 8.44 -8.22 - 8.36 -12.15

10.98 11.12

2.67 2.71

-- -- --

10.65 10.86

2.07 2.07

-- -- --

6.13

4.75

6.33

7.40

2.01

3.67

2.05

-3.55

--

-6.05

--

-6.29

--

-4.38

MSCI Emerging Markets Index

5.71

-12.03

--

--

--

2.38

Japan Stock Index Fund (22 Oct 2003)

- 6.58

- 7.30

3.57

3.72

- 0.69

3.03

MSCI Japan Index

- 6.52

- 7.06

3.84

4.03

- 0.42

3.26

Pacific ex-Japan Stock Index Fund (22 Jul 2005)

1.81

- 9.88

- 3.21

0.40

5.60

6.29

MSCI Pacific ex Japan Index

1.81

- 9.65

- 2.95

0.68

5.60

6.26

SRI European Stock Fund (2 Sep 2014)

- 2.31

- 8.04

--

--

--

-7.88

FTSE Developed Europe Index

-2.43

-8.00

--

--

--

-7.89

SRI Global Stock Fund (2 Sep 2014)

- 0.48

- 3.83

--

--

--

-2.28

FTSE Developed Index

- 0.26

- 3.39

--

--

--

-1.90

The performance data shown represent past performance, which is not a guarantee of future results. Investment returns and principal value will fluctuate, so investors' shares, when sold, may be worth more or less than their original cost. Current performance may be lower or higher than the performance data cited. For performance data current to the most recent month-end, visit our website at americas.

1 Income and accumulation shares expense ratio is 0.15%. 2 On 20 July 2009, the Fund, then Vanguard Prime Liquidity Money Market Fund, changed its name, investment objective and strategies. 3 Income and accumulation shares expense ratio is 0.15%.

FOR ACCREDITED AND INSTITUTIONAL INVESTOR AND FINANCIAL PROFESSIONAL USE ONLY. NOT FOR PUBLIC DISTRIBUTION.

Total returns (%)?Institutional USD shares Period ending 31 March 2016

Vanguard fund (Inception date)

Benchmark Active and quantitative equity Global Enhanced Equity Fund (18 Apr 2007)

MSCI World Index U.S. Discoveries Fund 1 (1 Jul 2004) Spliced Russell Microcap Growth Index/Granahan Investment Mgmt. U.S. Fundamental Value Fund 1 (3 May 2005)

Russell 1000 Value Index/Pzena Investment Mgmt. U.S. Opportunities Fund (8 Apr 2002)

Russell 3000 index/PRIMECAP Investment Mgmt. Index fixed income and money market Global Bond Index Fund USD Hedged (31 Mar 2008)

Spliced Barclays Global Aggregate Float Adjusted Bond Index U.S. Government Bond Index Fund (31 Jan 2002)

Spliced Barclays Global Aggregate U.S. Government Float Adjusted Bond Index U.S. Investment Grade Credit Index Fund (16 Dec 2004) Spliced Barclays Global Aggregate U.S. Credit Float Adjusted Index 2 Euro Government Bond Index Fund (10 Mar 2015) Spliced Euro Government Float Adjusted Bond Index 4 Euro Investment Grade Bond Index Fund 3 (29 Sep 2000) Spliced Euro Investment Grade Float Adjusted Bond Index 5 Eurozone Inflation-Linked Bond Index Fund 3 (31 May 2005) Barclays Global Inflation-Linked: Eurozone - Euro CPI Index U.K. Investment Grade Bond Index Fund 6 (20 Mar 2007) Barclays Global Aggregate GBP Non-Government Index 20+ Year Euro Treasury Index Fund 3 (29 Aug 2007)

Barclays Euro Aggregate Treasury 20+ Years Index (AA- and Above) Japan Government Bond Index Fund (10 Mar 2015)

Spliced Barclays Global Aggregate JPY Gov't Float Adjusted Index U.S. Ultra-Short-Term Bond Fund 7 (6 May 1999) Spliced BofA Merrill Lynch US 6 month U.S. Treasury Bill Index 8 Global Short-Term Bond Index Fund (31 Jan 2014) Barclays Global Aggregate 1-5 Years ex US MBS Float Adjusted Bond Index U.K. Government Bond Index Fund (23 Jun 2009)6 Spliced Barclays Global Aggregate U.K. Government Float Adjusted Bond Index 9 U.K. Short-Term Investment Grade Bond Index Fund (22 May 2013) Barclays Global Aggregate 500MM U.K. Non- Government 1-5Y Float Adjusted

1Q 2016

- 1.73 - 0.35 - 8.64 - 8.82 - 1.24

1.43 - 2.46

0.81

3.29 3.29 3.13 3.14 3.63 3.63 8.25 8.29 2.24 2.29 1.03 1.08 3.16 3.15 12.67 12.77 11.59 11.68 0.20 0.21 1.24 1.21 5.29 5.32 1.24 1.31

Average annual total returns

1 year

3 years

Since 5 years 10 years inception

- 3.73 - 3.45 - 19.36 - 17.07 - 6.72 - 2.28 - 1.95 - 0.93

7.85 6.82 6.74 6.60 7.35 8.60 16.19 10.51

7.99 6.51 8.90 6.28 7.79 9.44 14.11 10.36

-- -- 6.76 3.42 2.70 4.91 10.90 6.27

3.67 2.65 8.98 5.28 3.93 5.78 13.08 7.50

2.23 2.30 2.20 2.37 1.23 1.22

6.75 6.95 0.22 0.38

-2.89 -2.65 0.38 0.39 - 3.96 - 3.68 12.94 13.23 0.27 0.39 1.58 1.53 3.14 3.31 1.17 1.34

3.58 3.73 1.91 2.11 2.71 2.80

-- -- 3.80 3.92 4.40 4.60 4.83 4.84 12.09 12.39 -- -- 0.10 0.23 -- -- 4.85 5.00 -- --

4.48 4.64 3.29 3.45 4.73 4.79

-- -- 5.42 5.54 5.06 5.25 7.14 7.07 12.09 12.39 -- -- 0.10 0.22 -- -- 7.06 7.18 -- --

-- -- 4.44 4.54 5.48 5.51 -- -- 4.45 4.63 3.87 4.02 -- -- -- -- -- -- 1.20 1.31 -- -- -- -- -- --

4.33 4.54 4.38 4.50 4.95 4.97 6.90 7.12 4.90 5.16

3.51 3.66 5.78 5.79 8.62 8.90 14.28 14.58 1.98 1.98 1.84 1.85

6.37 6.43 2.15 2.27

1 Investor share class.

2 Barclays U.S. Credit Index USD through 31 Oct 2006; Spliced Barclays GA U.S. Credit Index thereafter.

3 Performance reported in Euros.

4 Citigroup EMU Governent Bond Index in Euros through 31 Dec 2004; Spliced Euro Government Bond Index in Euros thereafter.

5 Citigroup Non-EGBI EuroBIG in Euros through 31 Dec 2004; Barclays Global Inflation-Linked: Eurozone Bond Index in Euros thereafter.

6 Performance reported on British pound sterling.

7 On 20 July 2009, the Fund, then Vanguard Prime Liquidity Money Market Fund, changed its name, investment objective and strategies.

8

Money Market Funds Average for Investor share class or Institutional Money Market Funds Average for Institutional share class through 30 June 2009; BofA Merrill Lynch 6 Month U.S. Treasury Bill Index thereafter. The performance is derived from data provided by Lipper, a Thomson Reuters Company.

9 Barclays Global Aggregate U.K. Government Bond Index through 30 June 2010 and Barclays Global Aggregate U.K. Government Float Adjusted Bond Index thereafter.

FOR ACCREDITED AND INSTITUTIONAL INVESTOR AND FINANCIAL PROFESSIONAL USE ONLY. NOT FOR PUBLIC DISTRIBUTION.

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This information is intended for investors outside the United States. The information contained herein does not constitute an offer or solicitation and may not be treated as an offer or solicitation in any jurisdiction where such an offer or solicitation is against the law, or to anyone to whom it is unlawful to make such an offer or solicitation, or if the person making the offer or solicitation is not qualified to do so.

Figures are net of expenses.

Purchase fees are paid directly to the fund and are, therefore, not considered a sales load. Purchase fees protect existing shareholders by allocating costs only to those investors purchasing shares.

All investing is subject to risk, including possible loss of the money you invest. Investments in securities issued by non-U.S. companies are subject to risks including country/regional risk and currency risk. These risks are especially high in emerging markets. Bond funds are subject to the risk that an issuer will fail to make payments on time, and that bond prices will decline because of rising interest rates or negative perceptions of an issuer's ability to make payments.

All investing is subject to risk, including the possible loss of the money you invest. -- LA FECHA DE INICIO DE LA OFERTA SER? EL 29.2.2016 Y ESTA OFERTA SE ACOGE A LA NORMA DE CAR?CTER GENERAL N? 336 DELA SUPERINTENDENCIA DE VALORES Y SEGUROS CHILENA; -- LA OFERTA VERSA SOBRE VALORES NO INSCRITOS EN EL REGISTRO DE VALORES O EN EL REGISTRO DE VALORES EXTRANJEROS QUE LLEVA LASUPERINTENDENCIA DE VALORES Y SEGUROS CHILENA, POR LO QUE TALES VALORES NO EST?N SUJETOS A LA FISCALIZACI?N DE ?STA; --POR TRATAR DE VALORES NO INSCRITOS NO EXISTE LA OBLIGACI?N POR PARTE DEL EMISOR DE ENTREGAR EN CHILE INFORMACI?N P?BLICA RESPECTO DE ESOS VALORES; Y --ESOS VALORES NO PODR?N SER OBJETO DE OFERTA P?BLICA MIENTRAS NO SEAN INSCRITOS EN EL REGISTRO DE VALORESCORRESPONDIENTE.

The Products have not been and will not be registered with the Securities Commission of The Bahamas. The Products are offered to persons who are non-resident or otherwise deemed non-resident for Bahamian Exchange Control purposes. The Products are not intended for persons (natural persons or legal entities) for which an offer or purchase would contravene the laws of their state (on account of nationality or domicile/ registered office of the person concerned or for other reasons). Further, the offer constitutes an exempt distribution for the purposes of the Securities Industry Act, 2011 and the Securities Industry Regulations, 2012 of the Commonwealth of The Bahamas.

Shares may be offered or sold in Bermuda only in compliance with the provisions of the Investment Business Act of 2003 of Bermuda which regulates the sale of securities in Bermuda. Additionally, non-Bermudian persons (including companies) may not carry on or engage in any trade or business unless such persons are permitted to do so under applicable Bermuda legislation.

The Fund is not registered or recognized in British Virgin Islands and, as such, shares may not be offered to the public in The British Virgin Islands. However, shares may be offered to British Virgin Islands Business Companies and/or persons who are not members of the public from outside the British Virgin Islands. A British Virgin Islands Business Company is a company formed under or otherwise governed by the British Virgin Islands Business Companies Act, 2004 (British Virgin Islands).

The fund does not intend to establish a place of business or otherwise intend to conduct business in the Cayman Islands. Accordingly, the fund should not be subject to the supervision of any Cayman Islands authority.

Investment Products: Not FDIC Insured ? No Bank Guarantee ? May Lose Value

FOR ACCREDITED AND INSTITUTIONAL INVESTOR AND FINANCIAL PROFESSIONAL USE ONLY. NOT FOR PUBLIC DISTRIBUTION.

Vanguard Investment Series plc has been authorised in Ireland as a UCITS pursuant to the European Communities (Undertakings for Collective Investment in Transferable Securities) Regulations, 2003, as amended.

The difference between the sale and re-purchase price of units in Vanguard Investment Series plc (taking in account of possible portfolio transaction charges) means that any investment should be viewed as medium to long-term. Investors should also note that, in certain circumstances set out in the prospectus, a redemption charge may become payable.

London Stock Exchange Group companies include FTSE International Limited ("FTSE"), Frank Russell Company ("Russell"), MTS Next Limited ("MTS"), and FTSE TMX Global Debt Capital Markets Inc. ("FTSE TMX"). All rights reserved. "FTSE?", "Russell?", "MTS?", "FTSE TMX?" and "FTSE Russell" and other service marks and trademarks related to the FTSE or Russell indexes are trademarks of the London Stock Exchange Group companies and are used by FTSE, MTS, FTSE TMX and Russell under licence. All information is provided for information purposes only. No responsibility or liability can be accepted by the London Stock Exchange Group companies nor its licensors for any errors or for any loss from use of this publication. Neither the London Stock Exchange Group companies nor any of their licensors make any claim, prediction, warranty or representation whatsoever, expressly or impliedly, either as to the results to be obtained from the use of the FTSE Indices or the fitness or suitability of the Indices for any particular purpose to which they might be put.

S&P? and S&P 500? are registered trademarks of Standard & Poor's Financial Services LLC ("S&P") and have been licensed for use by S&P Dow Jones Indices LLC and its affiliates and sublicensed for certain purposes by Vanguard. The S&P Index is a product of S&P Dow Jones Indices LLC and has been licensed for use by Vanguard. The Vanguard Fund(s) is not sponsored, endorsed, sold or promoted by S&P Dow Jones Indices LLC, Dow Jones, S&P or their respective affiliates, and none of S&P Dow Jones Indices LLC, Dow Jones, S&P nor their respective affiliates makes any representation regarding the advisability of investing in such product(s).

The funds or securities referred to herein are not sponsored, endorsed, or promoted by MSCI, and MSCI bears no liability with respect to any such funds or securities. For any such funds or securities, the prospectus or the Statement of Additional Information contains a more detailed description of the limited relationship MSCI has with The Vanguard Group and any related funds.

The Russell 1000? Value Index, Russell 2000? Growth Index, Russell 3000? Index and Russell? are registered trademarks of Russell Investments and have been licensed for use by The Vanguard Group, Inc. The Product(s) are not sponsored, endorsed, sold or promoted by Russell Investments and Russell Investments makes no representation regarding the advisability of investing in the products.

? 2016 The Vanguard Group Inc. All rights reserved. Vanguard Marketing Corporation, Distributor

INTOPB_032016

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