Andy Felton Ph.D. Vice President Product Management

[Pages:36]State of the art of Ion Torrent technology

Andy Felton Ph.D. Vice President Product Management

1

Our Vision: Genetic Analysis

To be the most relevant provider of high value information to researchers and labs for genetic testing

Next-generation sequencing for genome, exome, or transcriptome

sequencing

Next-generation sequencing for targeted sequencing, and expression

analysis

Capillary electrophoresis for low-cost, targeted

variant analysis

Real-time PCR systems for variant ID, gene expression, and analysis of large numbers of samples

Digital PCR System for fast and simple rare allele detection and absolute target

quantification

Discover

Characterize

Analyze

2

Our Impact: Ion TorrentTM NGS Systems

1000's systems placed >600 tests implemented in clinical research labs

Hundreds of thousands of test results generated in clinical research labs

>1500 total publications >100 peer-reviewed clinical oncology research publications

For Research Use only. Not for use in diagnostic procedures.

3

Our View : Targeted Sequencing

Cost efficient, time efficient and simpler to analyze

Targeted Sequencing

Whole Exome

Whole Genome

Number of variants generated per run Likely number of relevant variants Time to analyze

Total cost Inc. analysis

4

10s to 100s 1-10s

Hours to days $

~50,000 1-10s

Days to Weeks $$

~3,000,000 1-10s

Weeks to Months $$$

Developing the simplest targeted sequencing workflow

Hard to Use

Easy to Use

5

2010

2012

2014

2016

The all new Ion S5TM and S5TM XL Systems.

6

A single platform for many NGS application areas

Cancer Research

Gene panels for SNPs, indels, copy number, gene expression and gene fusion detection

Inherited Disease Research

Gene panels and exomes for SNPs, indels and copy number

Reproductive Genomics Research

Aneuploidy detection

7

Infectious Disease Research

Microbial whole genomes, microbial typing, metagenomics

ApplicatioInosn S5 and Ion S5 XL Systems

Simplest and fastest targeted sequencing system with the lowest capital investment

? Simplest NGS workflow for targeted sequencing ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download