Vitamin D Assay Testing - Quest Diagnostics
[Pages:2]Medicare Local Coverage Determination Policy
Vitamin D Assay Testing
CPT: 82306, 82652
CMS Policy for Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, and Vermont
Local policies are determined by the performing test location. This is determined by the state in which your performing laboratory resides and where your testing is commonly performed.
Medically Supportive ICD Codes are listed on subsequent page(s) of this document.
Coverage Indications, Limitations, and/or Medical Necessity Vitamin D is a hormone, synthesized by the skin and metabolized by the kidney to an active hormone, calcitriol. An excess of vitamin D may lead to hypercalcemia. Vitamin D deficiency may lead to a variety of disorders. This LCD identifies the indications and limitations of Medicare coverage and reimbursement for these services.
Vitamin D is called a "vitamin" because of its exogenous source, predominately from oily fish in the form of vitamin D2 and vitamin D3. It is really a hormone, synthesized by the skin and metabolized by the kidney to an active hormone, calcitriol, which then acts throughout the body. In the skin, 7-dehydrocholesterol is converted to vitamin D3 in response to sunlight, a process that is inhibited by sunscreen with a skin protection factor (SPF) of 8 or greater. Once in the blood, vitamin D2 and D3 from diet or skin bind with vitamin D binding protein and are carried to the liver where they are hydroxylated to yield calcidiol. Calcidiol then is converted in the kidney to calcitriol by the action of 1-hydroxylase (CYP27B1). The CYP27B1 in the kidney is regulated by nearly every hormone involved in calcium homeostasis, and its activity is stimulated by PTH, estrogen, calcitonin, prolactin, growth hormone, low calcium levels, and low phosphorus levels. Its activity is inhibited by calcitriol, thus providing the feedback loop that regulates calcitriol synthesis.
An excess of vitamin D is unusual, but may lead to hypercalcemia. Vitamin D deficiency may lead to a variety of disorders, the most infamous of which is rickets. Evaluating patients' vitamin D levels is accomplished by measuring the level of 25-hydroxyvitamin D. Measurement of other metabolites is generally not medically necessary.
Indications
Measurement of vitamin D levels is indicated for patients with:
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chronic kidney disease stage III or greater;
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osteoporosis;
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osteomalacia;
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osteopenia;
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hypocalcemia;
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hypercalcemia;
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hypoparathyroidism;
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hyperparathyroidism;
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hypervitaminosis D;
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rickets; and
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vitamin D deficiency to monitor the efficacy of replacement therapy.
Limitations For Medicare beneficiaries, screening tests are governed by statute. Vitamin D testing may not be used for routine screening.
Once a beneficiary has been shown to be vitamin D deficient, further testing is medically necessary only to ensure adequate replacement has been accomplished. Thereafter, annual testing may be appropriate depending upon the indication and other mitigating factors.
Documentation Requirements: The patient's medical record must contain documentation that fully supports the medical necessity for services included within this LCD. (See "Indications and Limitations of Coverage.") This documentation includes, but is not limited to, relevant medical history, physical examination, and results of pertinent diagnostic tests or procedures.
Visit MLCP to view current limited coverage tests, reference guides, and policy information.
To view the complete policy and the full list of medically supportive codes, please refer to the CMS website reference
Medicare Local Coverage Determination Policy
Vitamin D Assay Testing
CPT: 82306, 82652
CMS Policy for Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, and Vermont
Local policies are determined by the performing test location. This is determined by the state in which your performing laboratory resides and where your testing is commonly performed.
Please refer to the Limitations or Utilization Guidelines section on previous page(s) for frequency information.
The ICD10 codes listed below are the top diagnosis codes currently utilized by ordering physicians for the limited coverage test highlighted above that are also listed as medically supportive under Medicare's limited coverage policy. If you are ordering this test for diagnostic reasons that are not covered under Medicare policy, an Advance Beneficiary Notice form is required. *Note--Bolded diagnoses below have the highest utilization
Code
CPT 82306 E21.0 E21.1 E21.3 E55.9 E66.01 E83.51 E83.52 K76.9 K90.9 M 81.0 M81.8 M 85.80 M85.89 M89.9 N18.30 N18.31 N18.32 N18.4 N25.81 Z79.4 Z79.899
CPT 82652
E55.9 E83.50 E83.52 M83.2 M83.8 N20.0
Description
Primary hyperparathyroidism Secondary hyperparathyroidism, not elsewhere classified Hyperparathyroidism, unspecified Vitamin D deficiency, unspecified Morbid (severe) obesity due to excess calories Hypocalcemia Hypercalcemia Liver disease, unspecified Intestinal malabsorption, unspecified Age -re lated osteoporosis without current pathological fracture Other osteoporosis without current pathological fracture Othe r specified disorders of bone density and structure, unspecified site Other specified disorders of bone density and structure, multiple sites Disorder of bone, unspecified
Chronic kidney disease, stage 4 (severe) Secondary hyperparathyroidism of renal origin Long term (current) use of insulin Other long term (current) drug therapy
Vitamin D deficiency, unspecified Unspecified disorder of calcium metabolism Hypercalcemia Adult osteomalacia due to malabsorption Other Adult osteomalacia, Calculus of kidney
Visit MLCP to view current limited coverage tests, reference guides, and policy information.
To view the complete policy and the full list of medically supportive codes, please refer to the CMS website reference
Last updated: 07/22/22
Disclaime r: This diagnosis code reference guide is provided as an aid to physicians and office staff in determining when an ABN (Advance Beneficiary Notice) is necessary. Diagnosis codes must be applicable to the patient's symptoms or conditions and must be consistent with document ation in the patient's medical record. Quest Diagnostics does not recommend any diagnosis codes and will only submit diagnosis information provided to us by the ordering physician or his/her designated staff. The CPT codes provided are based on AMA guidelines and are for i nformational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to th e payer being billed.
Que Quest, Quest Diagnostics, any associated logos, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third-party marks--? and TM--are the property of their respective owners. ? 2016 Quest Diagnostics Incorporated. All rights reserved.
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