Neonatal Anemia - UCSF Benioff Children's Hospital
Intensive Care Nursery House Staff Manual
Neonatal Anemia
BACKGROUND and PATHOPHYSIOLOGY: Normal erythropoiesis is influenced by several factors, especially erythropoietin (EPO), which stimulates maturation of red blood cell (RBC) precursors. Anemia, defined as hematocrit (Hct) or hemoglobin (Hgb) concentration >2 SD below mean for age, may be due to three general causes: blood loss, RBC destruction or RBC production. The major physiologic impact of anemia is oxygen delivery to tissue, resulting in both compensatory responses (see "symptoms") and acute or chronic consequences including poor growth, decreased activity and limited cardiovascular reserve. Anemia is defined as Hct ................
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