Oral Dosage Forms That Should Not Be Crushed 2016

Drug Product Absorica Accutane AcipHex Acticlate

Actiq

Actonel

Adalat CC Adderall XR AeroHist Plus Afeditab CR Afinitor Aggrenox Alavert Allergy (Sinus 12 hour) Allegra-D Alophen ALPRAZolam ER Altoprev Ambien CR Amibid DM Amitiza Ampyra Amrix Aplenzin Apriso Aptensio XR Aptivus Aquatab C Aquatab D

Oral Dosage Forms That Should Not Be Crushed 2016

Active Ingredient(s) (isotretinoin) (isotretinoin) (rabeprazole) (doxycycline)

(fentaNYL)

(risedronate)

(NIFEdipine) (amphetamine salts) (combination) (NIFEdipine) (everolimus) (combination) (combination) (combination) (bisacodyl) (ALPRAZolam) (lovastatin) (zolpidem) (combination) (lubiprostone) (dalfampridine) (cyclobenzaprine) (buPROPion) (mesalamine) (methylphenidate) (tipranavir) (combination) (combination)

Dosage Form(s) Capsule Capsule Tablet Capsule; Tablet

Lozenge

Tablet

Tablet Capsule Tablet Tablet Tablet Capsule Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Tablet Capsule Tablet Capsule Capsule Capsule Tablet Tablet

Reasons/Comments Mucous membrane irritant Mucous membrane irritant Slow-release Film-coated (h) (Note: tablet scored in thirds rather than half) Slow-release (Note: this lollipop delivery system requires the patient to slowly allow dissolution)

Irritant (Note: chewed, crushed, or sucked tablets may cause oropharyngeal irritation) Slow-release Slow-release (a) Slow-release (h) Slow-release Mucous membrane irritant Slow-release Slow-release Slow-release Enteric-coated Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release (Note: formerly fampridine-SR) Slow-release Slow-release Slow-release (a) (Note: maintain pH at < 6.0) Slow-release (a) Note: oil emulsion within spheres; taste Slow-release (h) Slow-release (h)

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Aricept 23 mg

Arthrotec Asacol Aspirin enteric-coated Atelvia

Augmentin XR AVINza Avodart

Azulfidine EN-Tabs Bayer EC Bayer Regular Belsomra

Belviq XR Biaxin-XL Bidex A Bidhist-D Biltricide Biohist LA Bisac-Evac Bisacodyl Bisa-Lax Boniva

Briviact

Oral Dosage Forms That Should Not Be Crushed 2016

(donepezil)

(diclofenac) (mesalamine) (aspirin) (risedronate)

Tablet

Tablet Tablet Caplet; Tablet Tablet

Note: crushing the 23 mg tablet may significantly increase the rate of absorption; the 5 mg and 10 mg tablets are not affected Enteric-coated Slow-release Slow-release; Enteric-coated Slow-release (Note: tablet coating is an important part of the slow-release; chewed, cut, or crushed tablets may cause oropharyngeal irritation)

(combination) (morphine) (dutasteride)

Tablet Capsule Capsule

Slow-release (b,h) Slow-release (a; not pudding) Note: drug may cause fetal abnormalities; women who are, or may become, pregnant, should not handle capsules; all women should use caution in handling capsules, especially leaking capsules

(sulfaSALAzine) (aspirin) (aspirin) (suvorexant)

Tablet Caplet Caplet Tablet

Slow-release (b) Enteric-coated Enteric-coated Note: not scored; no studies available from company

(lorcaserin) (clarithromycin) (combination) (combination) (praziquantel) (combination) (bisacodyl) (combination) (combination) (ibandronate)

(brivaracetam)

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet

Tablet

Slow-release Slow-release Slow-release Slow-release Taste (h) Slow-release (h) Enteric-coated (c) Enteric-coated (c) Enteric-coated (c) Note: chewed, crushed, or sucked tablets may cause oropharyngeal irritation Film-coated (b)

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Bromfed PD Budeprion SR Bunavail

Cabometyx Calan SR Carbatrol Cardene SR Cardizem

Cardizem CD Cardizem LA Cardura XL Cartia XT Cefaclor ER Ceftin Cefuroxime CellCept Cerdelga Charcoal Plus Chlor-Trimeton 12-H Cholbam

Cipro XR Claritin-D 12 Hour Claritin-D 24 Hour Colace Colestid Commit

Concerta Contrave

Oral Dosage Forms That Should Not Be Crushed 2016

(combination) (buPROPion) (combination)

(cabozantinib) (verapamil) (carBAMazepine) (niCARdipine) (diltiazem)

(diltiazem) (diltiazem) (doxazosin) (diltiazem) -----(cefuroxime) -----(mycophenolate) (eliglustat) -----(combination) (cholic acid)

(ciprofloxacin) (combination) (combination) (docusate) (colestipol) (nicotine)

Capsule Tablet Buccal film

Tablet Tablet Capsule Capsule Tablet

Capsule Tablet Tablet Capsule Tablet Tablet Tablet Capsule; Tablet Capsule Tablet Tablet Capsule

Tablet Tablet Tablet Capsule Tablet Lozenge

Slow-release Slow-release Note: chewing or swallowing may result in lower peak concentrations and bioavailability Film-coated Slow-release (h) Slow-release (a) Slow-release Note: although not in the package insert, the drug has a coating that is intended to release the drug over approximately 3 hours Slow-release Slow-release Slow-release Slow-release Slow-release (b) Taste (b) (Note: use suspension for children) Taste (b) (Note: use suspension for children) Teratogenic potential (i) Preferably taken with water Enteric-coated Slow-release (b) Note: capsules may be opened and the contents mixed with food/drink Slow-release (b) Slow-release Slow-release Taste (e) Slow-release Note: integrity compromised by chewing or crushing

(methylphenidate) (combination)

Tablet Tablet

Slow-release Slow-release (Note: chewing, dividing, or crushing tablets may alter release rate)

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Coreg CR

Cotazym-S Covera-HS Creon 5, 10, 20 Crixivan

Cymbalta

Cytovene Cytoxan

Depakene Depakote Depakote ER Detrol LA Dexilant Diclegis Dilacor XR Dilatrate-SR Dilt-CD Diltia XT Ditropan XL Divalproex ER Doxidan Drisdol Droxia

Dulcolax Durlaza DynaCirc CR

Oral Dosage Forms That Should Not Be Crushed 2016

(carvedilol)

(pancrelipase) (verapamil) (pancrelipase) (indinavir)

(DULoxetine)

Capsule

Capsule Tablet Capsule Capsule

Capsule

Slow-release (a) (Note: may add contents of capsule to chilled, not warm, applesauce and consume immediately) Enteric-coated (a) Slow-release Slow-release (a) Taste (Note: capsule may be opened and mixed with fruit puree [e.g., banana]) Slow-release (a) (Note: may add contents of capsule to apple juice or applesauce but NOT chocolate)

(ganciclovir) (cyclophosphamide)

(divalproex) (divalproex) (divalproex) (tolterodine) (dexlansoprazole) (combination) (diltiazem) (isosorbide) (diltiazem) (diltiazem) (oxybutynin) (divalproex) (bisacodyl) (ergocalciferol) (hydroxyurea)

(bisacodyl) (aspirin) (isradipine)

Capsule Tablet

Capsule Tablet Tablet Capsule Capsule Tablet Capsule Capsule Capsule Capsule Tablet Tablet Tablet Capsule Capsule

Capsule; Tablet Capsule Tablet

Skin irritant Note: drug may be crushed but company recommends using injection Slow-release; mucus membrane irritant (b) Slow-release Slow-release Slow-release Slow-release (a) Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release Enteric-coated (c) Liquid filled (d) Note: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administer Enteric-coated (c); Liquid-filled Slow-release Slow-release

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E.E.S. 400 Easprin EC-Naprosyn Ecotrin Adult Low Strength Ecotrin Maximum Strength Ecotrin Regular Strength Effer-K Effervescent Potassium Effexor XR Embeda E-Mycin Enablex Entocort EC Envarsus XR Epanova

Equetro Ergomar Erivedge

Ery-Tab Erythromycin Base Erythromycin Delayed-Release Erythromycin Stearate Evista Exalgo

Exjade

Extendryl JR

Oral Dosage Forms That Should Not Be Crushed 2016

(erythromycin) (aspirin) (combination) (aspirin) (aspirin) (aspirin) (potassium bicarbonate) -----(venlafaxine) (morphine sulfate) (erythromycin) (darifenacin) (budesonide) (tacrolimus) (omega-3-carboxylic acids)

(carBAMazepine) (ergotamine) (vismodegib)

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet Tablet Capsule Tablet Capsule

Capsule Tablet Capsule

(erythromycin) --------------(raloxifene) (HYDROmorphone)

(deferasirox)

Tablet Tablet Capsule Tablet Tablet Tablet

Tablet

Enteric-coated (b) Enteric-coated Enteric-coated Enteric-coated Enteric-coated Enteric-coated Effervescent tablet (f) Effervescent tablet (f) Slow-release Slow-release (a) Enteric-coated Slow-release Enteric-coated (a) Slow-release Note: contents of capsule may erode walls of Styrofoam or plastic materials Slow-release (a) Sublingual form (g) Note: package insert indicates potential teratogenic effects; material safety data sheet warns against skin contact; health care workers should take appropriate precautions Enteric-coated Enteric-coated Enteric-coated pellets (a) Enteric-coated Taste; teratogenic potential (i) Slow-release (Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose) Note: do not give as whole tablet, tablets are meant to be given as oral suspension; see company insert

(combination)

Capsule

Slow-release

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Extendryl SR Farydak Feen-a-mint Feldene FentaNYL

Fentora Feosol Feratab Fergon Fero-Grad 500 mg Ferro-Sequels Flagyl ER Fleet Laxative Flomax Focalin XR Fortamet Fosamax Gleevec

GlipiZIDE XR Glucophage XR Glucotrol XL Glumetza Gralise Guaifed Guaifed-PD Guaifenex DM Guaifenex GP Guaifenex PSE GuaifFENesin/Pseudoephedrine GuaiMAX-D Halfprin 81

Oral Dosage Forms That Should Not Be Crushed 2016

(combination) (panobinostat) (bisacodyl) (piroxicam) ------

(fentaNYL) (ferrous sulfate) (ferrous sulfate) (ferrous gluconate) (combination) (combination) (metroNIDAZOLE) (bisacodyl) (tamsulosin) (dexmethylphenidate) (metFORMIN) (alendronate) (imatinib)

(glipiZIDE) (metFORMIN) (glipiZIDE) (metFORMIN) (gabapentin) (combination) (combination) (combination) (combination) (combination) -----(combination) (aspirin)

Capsule Capsule Tablet Capsule Lozenge

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet Tablet Tablet

Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet Tablet Tablet Tablet Tablet Tablet

Slow-release (b) Irritant Enteric-coated (c) Mucous membrane irritant Slow-release (Note: this lollipop delivery system requires the patient to slowly dissolve in mouth)

Note: buccal tablet; swallow whole Enteric-coated (b) Enteric-coated (b) Enteric-coated Slow-release Slow-release Slow-release Enteric-coated (c) Slow-release Slow-release (a) Slow-release Mucous membrane irritant Taste (h) (Note: may be dissolved in water or apple juice) Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release Slow-release (h) Slow-release Slow-release (h) Slow-release Slow-release Enteric-coated

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Hetlioz

Hista-Vent DA Horizant Hydrea

Hysingla ER

Imbruvica

Imdur Impavido

Inderal LA Indocin SR InnoPran XL Intelence

Intermezzo Intuniv Invega Iressa

Isoptin SR Isordil Sublingual Isosorbide Dinitrate Sublingual Isosorbide SR Jakafi

Oral Dosage Forms That Should Not Be Crushed 2016

(tasimelteon)

Capsule

Note: not scored; no studies available from company

(combination) (gabapentin) (hydroxyurea)

(HYDROcodone)

Tablet Tablet Capsule

Tablet

Slow-release (h) Slow-release Note: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administer Slow-release (Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose of HYDROcodone)

(ibrutinib)

Capsule

Note: not scored; no studies available from company

(isosorbide) (miltefosine)

Tablet Capsule

Slow-release (h) Note: not scored; no studies available from company

(propranolol) (indomethacin) (propranolol) (etravirine)

(zolpidem) (guanFACINE) (paliperidone) (gefitinib)

Capsule Capsule Capsule Tablet

Tablet Tablet Tablet Tablet

Slow-release Slow-release (a,b) Slow-release Note: tablet should be swallowed whole and not crushed; tablet may be dispersed in water Sublingual form (g) Slow-release Slow-release Note: tablet may be dissolved in 4-8 ounces of water

(verapamil) (isosorbide) (isosorbide) (isosorbide) (ruxolitinib)

Tablet Tablet Tablet Tablet Tablet

Slow-release (h) Sublingual form (g) Sublingual form (g) Slow-release Note: see prescribing information for making a suspension

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Page 7 of 16

Jalyn

Janumet XR Jentadueto XR Kadian Kaletra Kaon-CL-10 Kapidex

Kapvay Kazano

K-Dur Keppra

Keppra XR Ketek Khedezla Klor-Con Klor-Con M Klotrix K-Lyte K-Lyte CL K-Lyte DS Kombiglyze XR

K-Tab LaMICtal XR Lenvima Lescol XL Letairis Levbid Levsinex Timecaps

Oral Dosage Forms That Should Not Be Crushed 2016

(combination)

(combination) (combination) (morphine) (combination) (potassium) (dexlansoprazole)

Capsule

Tablet Tablet Capsule Tablet Tablet Capsule

Mucous membrane irritant (Note: women who are, or may become, pregnant, should not handle crushed or broken tablets [l]) Slow-release Slow-release Slow-release (a) (Note: do not give via NG tubes) Film-coated Slow-release (b) Slow-release (a) (Note: name changed to Dexilant)

(cloNIDine) (combination)

Tablet Tablet

Slow-release Note: not scored; no studies available from company

(potassium) (levETIRAcetam)

(levETIRAcetam) (telithromycin) (desvenlafaxine) (potassium) (potassium) (potassium) (potassium) (potassium) (potassium) (combination)

Tablet Tablet

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet

Slow-release Taste (b) (Note: some extemporaneous formulas are pharmacy prepared) Slow-release (b) Slow-release (b) Slow-release Slow-release (b) Slow-release (b,h) Slow-release Effervescent tablet (f) Effervescent tablet (f) Effervescent tablet (f) Slow-release (Note: tablet matrix may remain in stool)

(potassium) (lamoTRIgine) (lenvatinib) (fluvastatin) (ambrisentan) (hyoscyamine) (hyoscyamine)

Tablet Tablet Capsule Tablet Tablet Tablet Capsule

Slow-release (b) Slow-release Note: may be dissolved in a small glass of liquid Slow-release Slow-release Slow-release (h) Slow-release

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