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Cutaneous mast cell degranulation releasing histamine and other inflammatory mediators. Typical culprits: Drugs (Radiocontrast dyes, ACE inhibitors, penicillin, NSAIDs) ... Wegener’s granulomatosis (granulomatosis with polyangitis) Microscopic polyangitis. Churg-Strauss syndrome (eosinophilic granulomatosis … ................
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