Pre-sedation Evaluation

Large doses can produce tremors, muscles twitching, and seizures. This is largely thought to be secondary to an active metabolite (normeperidine) whose accumulation can cause seizures. 3. FENTANYL (Sublimaze) General. Fentanyl (Sublimaze) is more rapid in onset (about thirty to sixty seconds) than morphine and is of much shorter duration. ................
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