Topic 16: Circulation and Gas Exchange (Ch. 42)
TABLE 22.3 shows that is much lower for both normal and sickle-cell hemoglobin when oxygen was lacking, but the sickle-cell hemoglobin was even less soluble under that condition than normal hemoglobin. Sickle-cell hemoglobin crystallizes in the absence of oxygen, and this can be very damaging to red blood cells and capillaries. (CH22) ................
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