3. Medications Altering Warfarin Pharmacokinetics and ...
If a decision is made to use vitamin K, it should be administered in a dose that will quickly lower the INR into a safe, but not subtherapeutic range without causing resistance once warfarin is reinstated241 or without exposing the patient to the risk of anaphylaxis.242 High doses of vitamin K, though effective, may lower the INR more than is necessary and may lead to warfarin … ................
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