Single Patient IND



Dacarbazine

FDA Approved

Risks Associated with Dacarbazine

Frequent (Between a 10-50% chance that this will happen)

• A low number of white blood cells may increase the risk of infection. It may become life-threatening. Symptoms of infection may include fever, pain, redness, and/or difficulty breathing.

• Low number of red blood cells that can causes tiredness and shortness of breath. May require a blood transfusion.

• Hairloss

• Loss of appetite and weight loss

• Muscle weakness of the whole body

• Pain in the head

• Low blood pressure, which may cause dizziness, lightheadedness or fainting.

• Feeling sick to the stomach

• Vomiting

Occasional (Between a 1-10% chance that this will happen)

• Allergic reaction that may include a rash, hives, fever, difficulty breathing, and low blood pressure. Although usually reversible with treatment, it can be severe or life threatening.

• Blood clots can form leading to swelling in the arms and legs. These clots can travel to the lungs causing shortness of breath or to the brain causing a stroke. This may be serious or life threatening.

• Bleeding in the brain

• A reaction at the site where an injection (shot) was given, which may cause some redness and swelling. Notify your clinical team if you see this happen to you.

• Liver damage which can cause fatigue, and jaundice (yellowing of the skin and eyes). Although this is usually mild and reversible, this can be serious or life threatening and may require hospitalization and surgery.

• Increased sensitivity to sunlight

• Convulsion or seizure

• Low number of platelets, which may cause bleeding and bruising. Bleeding may be serious or life threatening and may required a blood transfusion.

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DANA-FARBER / HARVARD CANCER CENTER

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