RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA ...
SYNOPSIS
Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore
“STUDY OF hs-CRP, MYELOPEROXIDASE, AND MDA IN TYPE 2 DIABETES MELLITUS WITH AND WITHOUT HYPERTENSION ” – A CASE CONTROL STUDY.
Name of the candidate : Dr. Mohamedi Begum
Guide : Dr. Ashok Kumar J
Course and Subject : M.D. (Biochemistry)
Department of Biochemistry,
A J Institute of Medical Sciences,
Kuntikana, Mangalore – 575004.
2011
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BANGALORE.
ANNEXURE II
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
|1 |Name of the candidate and address (in block |DR. MOHAMEDI BEGUM, |
| |letters) |POST GRADUATE RESIDENT,(MD) |
| | |DEPARTMENT OF BIOCHEMISTRY, |
| | |A J INSTITUTE OF MEDICAL SCIENCES MANGALORE. |
|2 |Name of the Institution |A J INSTITUTE OF MEDICAL SCIENCES MANGALORE. |
|3 |Course of study and Subject |MD BIOCHEMISTRY. |
|4 |Date of admission to course |30/05/2011 |
|5 |Title of the Topic: “STUDY OF hs-CRP, MYELOPEROXIDASE , AND MDA IN TYPE 2 DIABETES MELLITUS WITH AND WITHOUT HYPERTENSION” – A |
| |CASE CONTROL STUDY. |
|6 | BRIEF RESUME OF THE INTENDED WORK |
| |6.1 NEED FOR STUDY |
| | |
| | |
| |Diabetes is a metabolic -disorder with inappropriate hyperglycemia either |
| | |
| |due to an absolute or relative deficiency of insulin secretion or reduction in |
| | |
| |the biologic effectiveness of insulin or both. It is also associated with disturbances |
| | |
| |concerned with protein, carbohydrate and lipid metabolism. The decreased uptake of |
| | |
| |glucose into muscle and adipose tissue leads to chronic extra cellular hyperglycemia |
| | |
| |which results in tissue damage and chronic vascular complications in both type 1 and 2 |
| | |
| |Diabetes Mellitus . [1] |
| | |
| |Hypertension affects approximately 70% of patients with diabetes and is |
| | |
| |approximately twice as common in persons with diabetes as in those without.[2] |
| | |
| |Hypertension in patients with diabetes causes a significant increase in the risk of |
| | |
| |vascular complications in this population.[2] |
| | |
| |The abnormalities in diabetic contribute to cellular events that causes atherosclerosis and |
| | |
| |subsequently increases the risk of the adverse cardiovascular events.[3] |
| | |
| |A study has demonstrated that elevated levels of hs-CRP are associated with |
| | |
| |increased cardiovascular risk.[4] |
| | |
| |The oxidative stress biomarkers Myeloperoxidase( MPO) powerfully enhances |
| | |
| |cardiovascular risk prediction.[5] |
| | |
| |Serum MDA level was significantly higher in longer duration of diabetes (>5 years) |
| | |
| |and presence of complications(both microvascular and macrovascular).[6] |
| | |
| |Risk of CVD increased significantly with increasing Total Cholesterol(TC) and Low |
| | |
| |Density Lipoproteins (LDL) Cholesterol.[7] |
| | |
| | |
| |6.2 REVIEW OF LITERATURE |
| |Amanullah et al. reported that in diabetic subjects hs-CRP level positively correlated with |
| |HbA1c.[1] |
| |Heslop et al. reported that measuring both MPO and CRP (C-reactive protein; a |
| |cardiac-related marker of inflammation) has added benefit for risk prediction |
| |of cardiovascular mortality than just measuring CRP alone.[5] |
| |Anand et al. reported that both hypertension and diabetes were proven as independently associated with an increased risk of CVD. |
| |Detection of hs-CRP should be given consideration while assessing cardiovascular risk in order to evaluate the risk of |
| |atherosclerotic vascular disease especially in patients with a hperlipidemia ,hypertension and diabetes to detect early CVD.[7] |
| | |
| |6.3 OBJECTIVE OF THE STUDY |
| |.To compare and to correlate the serum hs-CRP, Myeloperoxidase, Malondialdehyde,between patients with type 2 diabetes without |
| |hypertension, type 2 |
| |diabetes with hypertension and age and sex matched normal controls. |
| |.To correlate the levels hs-CRP, Myeloperoxidase, Malondialdehyde with glycemic control(HbA1c) between patients with type 2 |
| |diabetes without hypertension and type 2 diabetes with hypertension. |
| |.To correlate and to the levels of hs-CRP, Myeloperoxidase, and Malondialdehyde with Body Mass Index , waist hip ratio of the |
| |patient. |
| |.To correlate the levels of hs-CRP, Myeloperoxidase, MDA and lipid profile between patients with type 2 diabetes without |
| |hypertension and type 2 diabetes with hypertension. |
| | |
| |MATERIALS AND METHODS |
| |7.1 SOURCE OF DATA |
| |Individuals in the age group of 35-65 years who come to AJIMS hospital, Mangalore, |
| |diagnosed as diabetics (newly diagnosed or known diabetics on treatment) and diabetes |
| |with hypertension during the year 2011-2013 are considered as cases and are included in the |
| |study with age and sex matched controls. |
| | |
| | |
| |INCLUSION CRITERIA |
| |a)Age more than 35 years and less than 65 years. |
| |b) Known cases of type 2 diabetes mellitus on treatment and or newly diagnosed type 2 diabetes mellitus with and without |
| |hypertension. |
| |c)serum creatinine ................
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