Original Article Causes and management of ...

Int J Clin Exp Med 2016;9(6):12060-12066

/ISSN:1940-5901/IJCEM0022782

Original Article

Causes and management of

hyperbilirubinemia in full-term newborns

Yan-Ping Zhu1, Jun Wang2, Ming-Xia Li1

Department of Neonatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000,

P. R. China; 2Department of Pediatrician, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P. R. China

1

Received December 27, 2015; Accepted May 4, 2016; Epub June 15, 2016; Published June 30, 2016

Abstract: Objective: To investigate the major causes and current management of hyperbilirubinemia in full-term

newborns in a general hospital. Methods: The clinical and laboratory data of 1,455 full-term newborns with hyperbilirubinemia in the department of neonatology were collected for retrospective and descriptive analysis. Univariate

logistic analysis was used to compare the risk factors for hyperbilirubinemia in these two groups (the mild-to-moderate and severe jaundice groups). The impact of feeding models (breastfeeding, formula feeding, and mixed feeding)

on bilirubin metabolism in inpatients was analyzed. The severity of hyperbilirubinemia was compared in inborn and

outborn groups. Results: The top three major causes of hyperbilirubinemia in hospitalized full-term newborns were

jaundice of unknown cause, jaundice due to early feeding insufficiency, and breastfeeding jaundice. Comparison

between the mild-to-moderate and severe jaundice groups showed that hemolytic disease of the newborn and

neonatal infection were two main risk factors in the severe jaundice group (P ................
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