Interpretation of a Culture and Sensitivity Report

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Interpretation of a Culture and Sensitivity Report

JESSICA THOMPSON, PHARMD, BCPS (AQ-ID)

Goals

Briefly review the interpretation of culture and sensitivity reports

Example C/S report

Tracheal aspirate: Pseudomonas aeruginosa

Antibiotic

MIC

Interpretation

Aztreonam

8

S

Ceftriaxone

> 32

R

Ceftazidime

4

S

Ciprofloxacin

1

S

Gentamicin

2

S

Meropenem

1

S

Piperacillin/tazobactam

16

S

Interpreting a C/S Report

WHAT IT TELLS YOU

WHAT IT DOES NOT TELL YOU

Identifies bacteria/fungus present (most of the time)

Sensitivity results based on lab data

Human vs lab

Does not identify infection vs colonization vs contamination

Don't treat colonization or contamination

Does not tell you which antibiotic to use

"Susceptibility testing is an in vitro phenomenon and does not necessarily reflect or predict in vivo efficacy. Susceptibility testing is subject to great variability depending on pathogen tested, media used, conditions of incubation, and method of accessing bacterial growth"

BURKE A CUNHA

Example C/S report

Tracheal aspirate: Pseudomonas aeruginosa

Antibiotic

MIC

Interpretation

Aztreonam

8

S

Ceftriaxone

> 32

R

Ceftazidime

4

S

Ciprofloxacin

1

S

Gentamicin

2

S

Meropenem

1

S

Piperacillin/tazobactam

16

S

definitions

MIC

? Minimum concentration of an antibiotic needed to inhibit

visible growth of a single isolate of an organism

? Important for definitive treatment of an individual patient

Breakpoint ? Discriminatory concentrations used in the interpretation of

results of susceptibility testing to define isolates as susceptible,

intermediate, or resistant (determined by various organizations

- FDA, CLSI, EUCAST)

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