The Survey on Screen Multiple drugs from meconium of ...
SURVEY OF ILLICIT DRUG USE DURING PREGNANCY IN THE GLASGOW AREA, BASED ON MECONIUM ANALYSIS
1G. M. Abd-El-Azzim, 1R. A. Anderson, 2L. Jackson, 2C. H. Skeoch, 2S. Williamson
1Department of Forensic Medicine and Science, University of Glasgow.
2Neonatal Unit, Glasgow Royal Maternity Hospital.
A survey was carried out of prenatal exposure to illicit drugs amongst infants born at Glasgow Royal Maternity Hospital. Samples of meconium were collected anonymously from 400 neonates delivered between October and November 2000. Control samples were collected from newborn infants delivered in hospitals in Egypt who were unlikely to have been exposed to drugs in utero.
Methods:
The meconium was collected from diapers of the newborn infants using a plastic spoon and stored in a plastic vial at –4(C until analysed. The meconium sample weight used for analysis was 500 ( 50 mg, except for small samples in about 30 cases (about 11%), in which under 300 mg was available, while in 10 cases (4%) under 100 mg were available. Screening was performed in all cases by an Enzyme Immunoassay Technique. Subsequent extraction for confirmatory GC-MS analysis used Solid Phase Extraction (SPE) based on a single Bond Elut Certify column for most of the drugs considered (morphine, codeine, methadone, diazepam, temazepam, THC, THC-COOH). Amphetamine and methamphetamine were extracted using the Worldwide Monitoring Clean Screen ZSDAU020 column. Deuterated internal standards were added for each analyte. The basis for these extraction procedures was presented at the TIAFT Meeting in Helsinki.
Results:
• The most common drug detected was morphine, in around 45% of cases at
concentrations ranging from 1 to 1070 ng/g.
• Cannabinoids were present in 20% of cases. The THC concentrations ranged
from 250 to 1010 ng/g, while THC-COOH ranged from 80 to 416 ng/g.
• Benzodiazepines around (18%), including diazepam (700 to 1281 ng/g) and
temazepam (100 to 545 ng/g).
• Methadone and cocaine were each detected in (4%) and were present at
concentrations ranging from 16.2 ng/g to 2190 ng/g, and 20 to 70 ng/g respectively.
• The lowest incidence was for amphetamine, detected in 8 cases (3%) at
concentrations in the range 1 to 25.6 ng/g. Methamphetamine derivatives were tentatively detected in more than 130 cases (43%). However, most of these could not be confirmed, as the meconium sample size was too small. Those cases which could be confirmed contained MDMA (1 case, 3 ng/g) and MDA (2-47.8 ng/g).
Keywords: meconium; illicit drugs; neonate; SPE
(G.Azzim@formed.gla.ac.uk)
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- 2003 2004 bill 910 methamphetamine manufacturing of is a
- chapter 16 drugs and crime sage publications inc
- methamphetamine manufacturing trends
- the survey on screen multiple drugs from meconium of
- updated sentencing memorandum
- indiana medical protocols for drug endangered children dec
- chapter 10 drug abuse and drug trafficking
- pathological gambling among methamphetamine
Related searches
- buy generic drugs from india
- clean drugs from urine quickly
- removing drugs from your system
- drugs from canada online
- drugs from canada with prescription
- mail order prescription drugs from canada
- drugs from canada to usa
- order prescription drugs from canada
- prescription drugs from canada to usa
- discount prescription drugs from canada
- how to order prescription drugs from canada
- prescription drugs from canada legal