What should I do with a positive ANA or RF?

•Low concentrations are found in normal individuals •Solid phase essays (e.g. ELISA): automated, lower cost, higher false-negative rate •The IIF test for ANA is the gold standard (more sensitive) •ANA at a titer of ≥1:80 on HEp-2 cells is considered positive/ abnormal, but low specificity ................
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