Biochemistry



Pathology

Lecture 46 Intestinal Neoplasms

1) To be familiar with neoplasms of esophagus, specifically squamous cell carcinoma and adenocarcinoma, including predisposing factors, clinical features, and pathologic findings. See table from Lecture 41 question 5.

2) To know the types of neoplasms affecting the small intestine.

Benign: adenomas, mesenchymal tumors, lipomas, angiomas, and hemartomatous mucosal lesions.

Malignant: adenocarcinomas, carcinoids, lymphomas and sarcomas.

3) To know the types of adenomas affecting the small bowel.

Most adenomas occur in the region of the ampulla of Vater. They account for 25% of benign small intestinal tumors, present in 30-60 year old patient with a call to blood loss, rarely with obstruction.

4) To be familiar with the nature of carcinoid tumors, their distribution, biologic behavior, and clinical course, and pathologic findings of carcinoid.

Carcinoid tumors are carcinoma like the with a much more indolent clinical course. They are derived from resident endocrine cells, with the GI tract and the lung as the predominant sites of occurrence. Mucosal endocrine cells generate bioactive compounds, particularly peptide and nonpeptide hormones, and play a major role and coordinated gut function. Five-year survival is 90%.

Distribution: primarily in the GI tract with ................
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