Melanoma of the Skin - College of American Pathologists
Melanoma of the Skin
Protocol applies to melanoma of cutaneous surfaces only.
Protocol revision date: January 2005
Based on AJCC/UICC TNM, 6th edition
Procedures
• Biopsy (No Accompanying Checklist)
• Excision
• Re-excision
Authors
Carolyn Compton, MD, PhD
Department of Pathology, McGill University, Montreal, Quebec, Canada
Raymond Barnhill, MD
Department of Pathology, George Washington University Medical Center, Washington, DC
Mark R. Wick, MD
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
Charles Balch, MD
American Society of Clinical Oncology, Alexandria, Virginia
For the Members of the Cancer Committee, College of American Pathologists
© 2005. College of American Pathologists. All rights reserved.
The College does not permit reproduction of any substantial portion of these protocols without its written authorization. The College hereby authorizes use of these protocols by physicians and other health care providers in reporting on surgical specimens, in teaching, and in carrying out medical research for nonprofit purposes. This authorization does not extend to reproduction or other use of any substantial portion of these protocols for commercial purposes without the written consent of the College.
The College of American Pathologists offers these protocols to assist pathologists in providing clinically useful and relevant information when reporting results of surgical specimen examinations of surgical specimens. The College regards the reporting elements in the “Surgical Pathology Cancer Case Summary (Checklist)” portion of the protocols as essential elements of the pathology report. However, the manner in which these elements are reported is at the discretion of each specific pathologist, taking into account clinician preferences, institutional policies, and individual practice.
The College developed these protocols as an educational tool to assist pathologists in the useful reporting of relevant information. It did not issue the protocols for use in litigation, reimbursement, or other contexts. Nevertheless, the College recognizes that the protocols might be used by hospitals, attorneys, payers, and others. Indeed, effective January 1, 2004, the Commission on Cancer of the American College of Surgeons mandated the use of the checklist elements of the protocols as part of its Cancer Program Standards for Approved Cancer Programs. Therefore, it becomes even more important for pathologists to familiarize themselves with the document. At the same time, the College cautions that use of the protocols other than for their intended educational purpose may involve additional considerations that are beyond the scope of this document.
Summary of Changes to Checklist(s)
Protocol revision date: January 2005
No changes have been made to the data elements of the checklist(s) since the January 2004 protocol revision.
Surgical Pathology Cancer Case Summary
Protocol revision date: January 2005
Applies to invasive melanoma only
Based on AJCC/UICC TNM, 6th edition
MELANOMA OF THE SKIN: Excision, Re-Excision
Patient name:
Surgical pathology number:
Note: Check 1 response unless otherwise indicated.
MACROSCOPIC
Specimen Type
___ Excision, ellipse
___ Excision, wide
___ Excision, other (specify): ____________________________
___ Re-excision, ellipse
___ Re-excision, wide
___ Re-excision, other (specify): ____________________________
___ Lymphadenectomy, sentinel node(s)
___ Lymphadenectomy, regional nodes (specify): ____________________________
___ Other (specify): ____________________________
___ Not specified
Macroscopic Tumor
___ Present
___ Absent
___ Indeterminate
Tumor Site
Specify (if known): ____________________________
___ Not specified
Lesion Size
Greatest dimension: ___ cm
*Additional dimensions: ___ x ___ cm
___ Cannot be determined (see Comment)
Satellite Nodule(s)
___ Absent
___ Present (specify): ____________________________
___ Cannot be determined
*Pigmentation
*___ Absent
*___ Present, diffuse
*___ Present, patchy/focal
*___ Indeterminate
*___ Cannot be determined
MICROSCOPIC
Histologic Type
___ Superficial spreading melanoma
___ Lentigo maligna melanoma
___ Nodular melanoma
___ Acral lentiginous melanoma
___ Mucosal-lentiginous melanoma
___ Desmoplastic (spindle desmoplastic; neuroid) melanoma
___ Neurotropic melanoma
___ Malignant blue nevus
___ Melanoma in congenital melanocytic nevi
___ Minimal deviation (nevoid) melanoma
___ Other (specify): ____________________________
___ Melanoma, type cannot be determined
Ulceration
___ Present
___ Absent
Depth of Invasion
Specify: ___ mm
___ Cannot be determined (see Comment)
Pathologic Staging (pTNM)
Primary Tumor (pT)
___ pTX: Primary tumor cannot be assessed (see Comment)
___ pT0: No evidence of primary tumor
___ pTis: Melanoma in situ (ie, not an invasive tumor: level I)
pT1: Melanoma 1.0 mm or less in thickness, with or without ulceration
___ pT1a: Melanoma 1.0 mm or less in thickness and level II or III, no ulceration
___ pT1b: Melanoma 1.0 mm or less in thickness and level IV or V or with ulceration
pT2: Melanoma 1.01 to 2mm in thickness, with or without ulceration
___ pT2a: Melanoma 1.01 to 2.0 mm in thickness, no ulceration
___ pT2b: Melanoma 1.01 to 2.0 mm in thickness, with ulceration
pT3: Melanoma 2.01 to 4.0 mm in thickness, with or without ulceration
___ pT3a: Melanoma 2.01 to 4.0 mm in thickness, no ulceration
___ pT3b: Melanoma 2.01 to 4.0 mm in thickness, with ulceration
pT4: Melanoma greater than 4.0 mm in thickness, with or without ulceration
___ pT4a Melanoma greater than 4.0 mm in thickness, no ulceration
___ pT4b Melanoma greater than 4.0 mm in thickness, with ulceration
Regional Lymph Nodes (pN)
___ pNX: Regional lymph nodes cannot be assessed
___ pN0: No regional lymph node metastasis
pN1: Metastasis in 1 regional lymph node
___ pN1a: Clinically occult (microscopic) metastasis
___ pN1b: Clinically apparent (macroscopic) metastasis
pN2: Metastasis in 2 to 3 regional nodes or intra-lymphatic regional metastasis without nodal metastasis
___ pN2a: Clinically occult (microscopic) metastasis
___ pN2b: Clinically apparent (macroscopic) metastasis
___ pN2c: Satellite or in-transit metastasis without nodal metastasis
___ pN3: Metastasis in 4 or more regional lymph nodes, or matted metastatic nodes, or in-transit metastasis or satellites(s) with metastasis in regional node(s)
Number identified: ____
Number containing metastases identified macroscopically: ____
Number containing metastases identified microscopically: ____
Matted nodes:
___ Present
___ Absent
Distant Metastasis (pM)
___ pMX: Presence of distant metastasis cannot be assessed
___ pM1: Distant metastasis (documented in this specimen)
*___ pM1a: Metastasis in skin, subcutaneous tissues, or distant lymph nodes
*___ pM1b: Metastasis to lung
*___ pM1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH)
*(Other site, specify: ____________________________)
Margins (check all that apply)
Lateral Margins
___ Cannot be assessed
___ Uninvolved by invasive melanoma
Distance of invasive melanoma from closest lateral margin: ___ mm
Specify location(s), if possible: ____________________________
___ Involved by invasive melanoma
Specify location(s), if possible: ____________________________
___ Uninvolved by melanoma in situ
Distance of melanoma in situ from closest margin: ___ mm
Specify location(s), if possible: ____________________________
___ Involved by melanoma in situ
Specify location(s), if possible: ____________________________
Deep Margin
___ Cannot be assessed
___ Uninvolved by invasive melanoma
Distance of invasive melanoma from margin: ___ mm
Specify location(s), if possible: ____________________________
___ Involved by invasive melanoma
Specify location(s), if possible: ____________________________
*Venous (Large Vessel) Invasion (V)
*___ Absent
*___ Present
*___ Indeterminate
*Perineural Invasion
*___ Absent
*___ Present
*___ Indeterminate
*Tumor-Infiltrating Lymphocytes
*___ Absent
*___ Nonbrisk
*___ Brisk
*Tumor Regression
*___ Absent
*___ Present involving less than 75%
*___ Present involving 75% or more of lesion
*Mitotic Index
*___ Less than 1 mitotic figure per mm2
*___ 1 or more mitotic figure per mm2
*Additional Pathologic Findings (check all that apply)
*___ Nevus remnant
*___ Actinic keratosis
*___ Other (specify): ____________________________
*Comment(s)
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