- in these patients we should exclude certain systemic ...

A high titer of anti-RNP, in the absence of other ANAs, strongly suggests mixed connective tissue disease (MCTD) (3,4,5,6,7,8). The RNP antigen is commonly found as an Sm/RNP protein complex, therefore, a positive patient result should be run in an anti-Sm test as an additional aid in the diagnosis of SLE. ................
................