Pedigree Webquest - Humble ISD



Name: __________________________ Pedigree Webquest

Part One

1. You will have to travel to a website to answer the questions below go to

A. What kinds of information are found on a pedigree chart? ___________________________________________________________________

B. Draw the symbol that represents a male. ________

C. Draw the symbol that represents a female. ________

D. What does a line in between two individuals represent? _____________________

E. How is an individual that is affected by the trait shown? _____________________

F. Describe how a pedigree chart differentiates between parents and offspring.

G. What is a generation? How many generations are depicted in the pedigree at the bottom of the page?

H. Look at the top pedigree. How many children does that couple have? What are there sexes of the children?

I. Look at the bottom pedigree. How many children does the original couple have? Are any of these children affected individuals? Explain.

J. In the bottom pedigree, in the fourth generation, list the sex of each child from oldest to youngest.

5. Click on the next website: and answer the following questions: Ignore the url they give you on the website.

A. What are monozygous twins? How are monozygous twins represented on a pedigree chart?

B. What are dizygous twins? How are they represented?

C. What is an X-linked trait?

D. What is meant by an affected individual? How is an affected person represented on a pedigree chart.

Part Two

1. Draw a pedigree chart for the following family. Carlisle and Esme are grandparents. They have 3 children, Carolina, Crystal, and Ellen. Carolina is married to Jacob and they have a daughter named Leah. Crystal is married to Edward and they have 3 children, Alice, Emmitt, and John. Ellen is married to Edward and has 2 daughters, Isabella and Rosalie.

Please refer back to the two links if you are not sure about how to depict this information.

2. Answer the following questions using the next website: and go to “How is it inherited”? (left column)

A. How does a boy get hemophilia?_____________________

B. How does a girl become a carrier? _______________________

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3. If a woman is a carrier and the male does not have hemophilia,

draw a Punnett Square and indicate the possible outcome.

Part Three

Now use the information that you learned about Hemophilia to complete your pedigree chart from Part Two of this lesson. Indicate that Carlisle, Ellen, John and Edward have hemophilia by shading in the symbols that represent them in the Pedigree Chart.

1. Explain in a sentence or two how hemophilia is inherited. Describe which parent gave John the defective allele for hemophilia and explain how you know.

Here are a few rules of logic to help you understand the genetics behind the pedigree

1. If neither parent show the trait:

a. the trait cannot be dominant.

b. the trait could be recessive and either parent or both could be

heterozygous carriers.

2. If one parent shows the trait:

a. the trait could be dominant and the affected parent could be heterozygous while the

unaffected parent is not a carrier

b. the trait could be recessive and the affected parent is homozygous while the unaffected

parent could be a heterozygous carrier

3. If both parents show the trait:

a. the trait could be dominant and both parents could be heterozygous carriers which

means that some of the children could be unaffected

b. the trait could be recessive meaning that both parents would have to be homozygous and all the children would have to be affected.

Label the Pedigree:

1. Which members of the family above are afflicted with Huntington’s Disease? ___________________

2. There are no carriers for Huntington’s Disease- you either have it or you don’t.

With this in mind, is Huntington’s disease caused by a dominant or recessive trait? ____________________________

3. How many children did individuals I-1 and I-2 have? _______________________________________________

4. How many girls did II-1 and II-2 have? ______________ How many have Huntington’s Disease? ________________

5. How are individuals III-2 and II-4 related? ________________________ I-2 and III-5? ________________________

Part Four

Read further about sex-linked genetic disorders:

1. What sex chromosomes are found in males?_______________________ Females?________________

2. Explain why females might carry a recessive X-linked trait, but not express it, whereas men always express X-linked recessive traits.

3. How many human X-linked traits are known?

4. Give 3 examples of non-female anatomical traits that are located on the X chromosome.

5. Draw and briefly explain using Punnett squares the following genetic crosses:

a. A woman with normal vision but who carries the colorblind gene marries a man with normal vision.

b. A colorblind man marries a woman homozygous for normal vision.

c. A colorblind man marries a carrier woman with normal vision.

6. What sex linked trait ran through the royal families of Europe?

7. How many genes are located on the Y chromosome?

8. How many genes located on the Y chromosome is involved in sperm production vs. cellular activities?

9. How many couples in America are infertile?______________

10. What is a significant cause of infertility in men?

Name: ________________________ Karyotyping Activity

In this exercise you will simulate human Karyotyping using digital images from actual genetic studies.

Go to

A) Click on “Chromosomes and Inheritance” on the left hand side of the page

B) Click on “Make a Karyotype” on the right hand side of the page

What is a Karyotype?

How is a Karyotype constructed?

Now read the directions and construct the Karyotype. Was that of a male or female? How do you know?

Go back to Chromosomes and Inheritance and click on “Using Karyotypes to predict genetic disorders”

What is an autosome? How many do humans have?

What is a sex chromosome and how many do humans have?

What % of Klinefelter’s cases goes undiagnosed? Click on Klinefelter’s

Back on Using Karyotypes to predict genetic disorders; Click on Play and watch how deletions and translocations occurs

Name 2 disorders caused by deletions.

What can be the outcome for a translocation with duplicated genes?

Go to biology.Arizona.edu/

This will take you to the University of Arizona’s “The Biology Project” page

On the left Activities column click on Karyotyping

Carefully read though the Introduction, G-Banding and Your Assignment.

Go to “Patient Histories”

Follow the directions to complete the each of the three Karyotypes.

PATIENT A:

1. Normal or abnormal Karyotype? Explain

2. Is your Karyotype that of a Male or female?

3. What notation would you use to characterize Patient A’s Karyotype?

4. What diagnosis would you give Patient A?

PATIENT B:

6. Normal or abnormal karyotype? Explain

7. Is your Karyotype that of a Male or female?

8. What notation would you use to characterize Patient B’s Karyotype?

9. What diagnosis would you give Patient B?

PATIENT C:

10. Normal or abnormal Karyotype? Explain

11. Is your Karyotype that of a Male or female?

12. What notation would you use to characterize Patient C’s Karyotype?

13. What diagnosis would you give Patient C?

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