American College of Cardiology
2015 SVT Guideline Data SupplementsTable of Contents TOC \o "1-1" \h \z \t "DS Title Level 1,1" Data Supplement 1. Nonrandomized Trials, Observational Studies, and/or Registries of Clinical Presentation and Differential Diagnosis Based on Symptoms – Section 2.3.1 PAGEREF _Toc428873443 \h 3Data Supplement 2. Randomized Trials Comparing Principles of Acute and Chronic Therapy – Section 2.4 PAGEREF _Toc428873444 \h 8Data Supplement 3. Nonrandomized Trials, Observational Studies, and/or Registries of Principles of Acute and Chronic Therapy – Section 2.4 PAGEREF _Toc428873445 \h 18Data Supplement 4. Randomized Trials Comparing Sinus Tachyarrhythmias – Section 3 PAGEREF _Toc428873446 \h 26Data Supplement 5. Nonrandomized Trials, Observational Studies, and/or Registries of Sinus Tachyarrhythmias – Section 3 PAGEREF _Toc428873447 \h 28Data Supplement 6. Nonrandomized Trials, Observational Studies, and/or Registries of Focal Atrial Tachycardia – Section 4.1 PAGEREF _Toc428873448 \h 33Data Supplement 7. Randomized Trials Comparing Multifocal Atrial Tachycardia – Section 4.2 PAGEREF _Toc428873449 \h 37Data Supplement 8. Nonrandomized Trials, Observational Studies, and/or Registries of Multifocal Atrial Tachycardia – Section 4.2 PAGEREF _Toc428873450 \h 38Data Supplement 9. Randomized Trials Comparing Atrioventricular Nodal Re-Entrant Tachycardia – Section 5 PAGEREF _Toc428873451 \h 39Data Supplement 10. Nonrandomized Trials, Observational Studies, and/or Registries of Atrioventricular Nodal Re-Entrant Tachycardia – Section 5 PAGEREF _Toc428873452 \h 57Data Supplement 11. Randomized Trials Comparing Manifest and Concealed Accessory Pathways – Section 6.1 PAGEREF _Toc428873453 \h 65Data Supplement 12. Nonrandomized Trials, Observations Studies, and/or Registires of Manifest and Concealed Accessory Pathways – Section 6.1 PAGEREF _Toc428873454 \h 66Data Supplement 13. Summary of Included Studies – ERC Report (Section 6.2) PAGEREF _Toc428873455 \h 71Data Supplement 14. Comparators and Outcomes – ERC Report (Section 6.2) PAGEREF _Toc428873456 \h 73Data Supplement 15. Quality Assesment of Included Studies – ERC Report (Section 6.2) PAGEREF _Toc428873457 \h 76Data Supplement 16. Randomized Trials Comparing Atrial Flutter – Section 7 PAGEREF _Toc428873458 \h 77Data Supplement 17. Nonrandomized Trials, Observational Studies, and/or Registries of Atrial Flutter – Section 7 PAGEREF _Toc428873459 \h 95Data Supplement 18. Randomized Trials for Junctional Tachycardia – Section 8 PAGEREF _Toc428873460 \h 99Data Supplement 19. Nonrandomized Trials, Observational Studies, and/or Registries of Junctional Tachycardia – Section 8 PAGEREF _Toc428873461 \h 99Data Supplement 20. Nonrandomized Trials, Observational Studies, and/or Registries of Special Populations – Section 9 PAGEREF _Toc428873462 \h 102Data Supplement 21. Randomized Trials Comparing Special Populations – Section 9 PAGEREF _Toc428873463 \h 122Data Supplement 22. Nonrandomized Trials, Observational Studies, and/or Registries of Quality-of-Life Considerations – Section 10 PAGEREF _Toc428873464 \h 123Data Supplement 23. Nonrandomized Trials, Observational Studies, and/or Registries of Cost Effectiveness – Section 11 PAGEREF _Toc428873465 \h 127Appendix 1. Acute Drug Therapy for SVT, Intravenous Administration* PAGEREF _Toc428873466 \h 132Appendix 2. Ongoing Drug Therapy for SVT, Oral Administration* PAGEREF _Toc428873467 \h 135Appendix 3. Success and Complication Rates for Ablation of SVT* PAGEREF _Toc428873468 \h 140References PAGEREF _Toc428873469 \h 141Methodology and Evidence ReviewThe recommendations listed in this guideline are, whenever possible, evidence based. An extensive evidence review was conducted in April 2014 that included literature published through September 2014. Other selected references published through May 2015 were incorporated by the writing committee. Literature included was derived from research involving human subjects, published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. The relevant search terms and data are included in Data Supplement evidence tables. Key search words included but were not limited to the following: ablation therapy (catheter and radiofrequency; fast and slow pathway), accessory pathway (manifest and concealed), antiarrhythmic drugs, atrial fibrillation, atrial tachycardia, atrioventricular nodal reentrant (reentry, reciprocating) tachycardia, atrioventricular reentrant (reentry, reciprocating) tachycardia, beta blockers, calcium channel blockers, cardiac imaging, cardioversion, cost effectiveness, cryotherapy, echocardiography, elderly (aged and older), focal atrial tachycardia, Holter monitor, inappropriate sinus tachycardia, junctional tachycardia, multifocal atrial tachycardia, paroxysmal supraventricular tachycardia, permanent form of junctional reciprocating tachycardia, pre-excitation, pregnancy, quality of life, sinoatrial node, sinus node reentry, sinus tachycardia, supraventricular tachycardia, supraventricular arrhythmia, tachycardia, tachyarrhythmia, vagal maneuvers (Valsalva maneuver), and Wolff-Parkinson-White syndrome. Data Supplement 1. Nonrandomized Trials, Observational Studies, and/or Registries of Clinical Presentation and Differential Diagnosis Based on Symptoms – Section 2.3.1StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsSganzerla P1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Sganzerla</Author><Year>1989</Year><RecNum>47</RecNum><IDText>Electrophysiologic and haemodynamic correlates in supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>47</Ref_ID><Title_Primary>Electrophysiologic and haemodynamic correlates in supraventricular tachycardia</Title_Primary><Authors_Primary>Sganzerla,P.</Authors_Primary><Authors_Primary>Fabbiocchi,F.</Authors_Primary><Authors_Primary>Grazi,S.</Authors_Primary><Authors_Primary>Cipolla,C.</Authors_Primary><Authors_Primary>Moruzzi,P.</Authors_Primary><Authors_Primary>Guazzi,M.D.</Authors_Primary><Date_Primary>1989/1</Date_Primary><Keywords>Adult</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Cardiac Output</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Hemodynamics</Keywords><Keywords>Humans</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>32</Start_Page><End_Page>39</End_Page><Periodical>Eur Heart J</Periodical><Volume>10</Volume><Issue>1</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Address>Istituto di Cardiologia, University of Milan, Italy</Address><Web_URL>PM:2702964</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(1)2702964Prospective, nonrandomized16AVNRTAll AVNRT Relationship between hemodynamic changes associated w/ artificially induced arrhythmias and the EP properties of the related AV nodal reentryGroup 1 AVNRT w/ short RPGroup 2 AVNRT w/ long RPNo significant difference between the CLs of the two types of SVT (329 and 330-8 ms)Atypical SVT differed from the typical one by a significantly smaller initial decrease and a more rapid recovery of BP. In group 1, cardiac output and arterial pressure were lower in SVR higher and PAP equal.Contraction on a closed valve may be a factor resulting in impaired pulmonary drainage leading to neural factors w/ reduced cardiac output.The induction of typical SVT (long AH) caused a marked initial fall in systemic BP w/ only a partial recovery, leading to stable hypotension and reduction of cardiac output owing to a decrease in stroke volume. On the contrary, in comparison to sinus rhythm, during the atypical SVT (long HA) a lesser degree of initial hypotension, a complete recovery of BP and no significant change in cardiac output were observed. The different hemodynamic response between the two types of SVT took place w/ the same increase in heart rate indicating that rate is not involved per se in the genesis of these circulatory changes. Simultaneous contraction more symptomatic for people. Bhandari AK1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJoYW5kYXJpPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJoYW5kYXJpPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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ADDIN EN.CITE.DATA (2)1636582Prospective study115 pts who were enrolled in a multicenter clinical trial of flecainidePts w/ SVT or AF or both,49 had SVTDetermine whether sx recorded w/ transtelephonic monitoring correlated w/ SVT or AFAmong 49 pts w/ PSVT, 62.7% of symptomatic calls were associated w/ ECG-documented PSVT as compared?w/ 6.6% of asymptomatic calls (p<0.001).The sensitivity of a symptomatic call was 91% for PSVTLeitch JW1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Leitch</Author><Year>1992</Year><RecNum>41</RecNum><IDText>Syncope associated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response?</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>41</Ref_ID><Title_Primary>Syncope associated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response?</Title_Primary><Authors_Primary>Leitch,J.W.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Leather,R.A.</Authors_Primary><Authors_Primary>Kim,Y.H.</Authors_Primary><Date_Primary>1992/3</Date_Primary><Keywords>Adult</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>complications</Keywords><Keywords>diagnostic use</Keywords><Keywords>etiology</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>methods</Keywords><Keywords>physiology</Keywords><Keywords>physiopathology</Keywords><Keywords>Posture</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Vasomotor System</Keywords><Reprint>Not in File</Reprint><Start_Page>1064</Start_Page><End_Page>1071</End_Page><Periodical>Circulation</Periodical><Volume>85</Volume><Issue>3</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University of Western Ontario, London, Canada</Address><Web_URL>PM:1537103</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(3)1537103Prospective, nonrandomizedN=2222 pts w/ SVTAVNRT 13AVRT 8AT 111 had a h/o syncopeExplore the mechanism of syncope during SVTLowest BP found in 1st 10 secCompensated BP w/in 60 sec w/ minimal change in CLshorter and BP lower w/ upright tiltComparison of the 7 pts w/ and the 15 pts w/o syncope. The only significant differences occurred in the extent of BP decrease during tachycardia (decrease in mean BP, 70±4 compared w/ 45+5 mm Hg; p=0.01) and in the frequency w/ which syncope occurred during passive tilt testing in sinus rhythm. The CL of tachycardia, in fact, tended to be longer in pts w/ syncope (311±10 compared w/ 290±+11 msec, p=0.27).Syncope is associated w/ vasodepressor mechanism and is not directly related to the tachycardia CLLee SH1995 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051
bT40MjwvUmVjTnVtPjxJRFRleHQ+RWZmZWN0cyBvZiBwcmVnbmFuY3kgb24gZmlyc3Qgb25zZXQg
YW5kIHN5bXB0b21zIG9mIHBhcm94eXNtYWwgc3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwv
SURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlw
ZT48UmVmX0lEPjQyPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+RWZmZWN0cyBvZiBwcmVnbmFuY3kg
b24gZmlyc3Qgb25zZXQgYW5kIHN5bXB0b21zIG9mIHBhcm94eXNtYWwgc3VwcmF2ZW50cmljdWxh
ciB0YWNoeWNhcmRpYTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkxlZSxTLkguPC9B
dXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuLFMuQS48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5Pld1LFQuSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PkNoaWFuZyxDLkUuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuZyxD
LkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5UYWksQy5ULjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hpb3UsQy5XLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+VWVuZyxLLkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5D
aGFuZyxNLlMuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk1LzEwLzE8L0RhdGVf
UHJpbWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9L
ZXl3b3Jkcz48S2V5d29yZHM+QWdlIG9mIE9uc2V0PC9LZXl3b3Jkcz48S2V5d29yZHM+QWdlZDwv
S2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVyIEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+
Q2hpLVNxdWFyZSBEaXN0cmlidXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lv
bG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFu
czwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5
c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJlZ25hbmN5PC9LZXl3b3Jkcz48S2V5
d29yZHM+UHJlZ25hbmN5IENvbXBsaWNhdGlvbnMsQ2FyZGlvdmFzY3VsYXI8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5RdWVzdGlvbm5haXJlczwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2sgRmFjdG9yczwv
S2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5TeW5jb3BlPC9L
ZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNh
cmRpYSxQYXJveHlzbWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3VwcmF2ZW50
cmljdWxhcjwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1Bh
Z2U+Njc1PC9TdGFydF9QYWdlPjxFbmRfUGFnZT42Nzg8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFt
IEogQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjc2PC9Wb2x1bWU+PElzc3VlPjEwPC9Jc3N1
ZT48SVNTTl9JU0JOPjAwMDItOTE0OTwvSVNTTl9JU0JOPjxNaXNjXzM+UzAwMDI5MTQ5OTk4MDE5
NTc8L01pc2NfMz48QWRkcmVzcz5EZXBhcnRtZW50IG9mIE1lZGljaW5lLCBOYXRpb25hbCBZYW5n
LU1pbmcgVW5pdmVyc2l0eSwgU2Nob29sIG9mIE1lZGljaW5lLCBUYWl3YW4sIFJlcHVibGljIG9m
IENoaW5hPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjc1NzI2MjM8L1dlYl9VUkw+PFpaX0pvdXJuYWxG
dWxsPjxmIG5hbWU9IlN5c3RlbSI+VGhlIEFtZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwv
Zj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+
QW0gSiBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9a
Wl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (4)7572623Retrospective review207 consecutive pts w/ h/o SVT107 pts AP mediated, 100 pts w/ AVNRTDetermine effects of pregnancy on SVT3.9% experienced first onset of SVT during pregnancy. Sx were exacerbated in 22% of pts w/ tachycardia in the pregnant and non-pregnant periods. Pregnancy exacerbates SVT in some but not all pts. Drago F1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Drago</Author><Year>1996</Year><RecNum>32</RecNum><IDText>Reciprocating supraventricular tachycardia in children: low rate at rest as a major factor related to propensity to syncope during exercise</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>32</Ref_ID><Title_Primary>Reciprocating supraventricular tachycardia in children: low rate at rest as a major factor related to propensity to syncope during exercise</Title_Primary><Authors_Primary>Drago,F.</Authors_Primary><Authors_Primary>Turchetta,A.</Authors_Primary><Authors_Primary>Calzolari,A.</Authors_Primary><Authors_Primary>Giordano,U.</Authors_Primary><Authors_Primary>Di,Ciommo,V</Authors_Primary><Authors_Primary>Santilli,A.</Authors_Primary><Authors_Primary>Pompei,E.</Authors_Primary><Authors_Primary>Ragonese,P.</Authors_Primary><Date_Primary>1996/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Aged</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Exercise</Keywords><Keywords>Exercise Test</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>physiology</Keywords><Keywords>physiopathology</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>280</Start_Page><End_Page>285</End_Page><Periodical>Am Heart J</Periodical><Volume>132</Volume><Issue>2 Pt 1</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Address>Department of Pediatric Cardiology, Bambino Gesu Children's Hospital, Scientific Institute of Research, Rome, Italy</Address><Web_URL>PM:8701888</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(5)8701888Prospective, nonrandomizedN = 22childrenVentriculoatrial interval <70 msec in 11 pts and >70 msec in 11The aim of this study was to evaluate, by using transesophageal atrial pacing and recording, the clinical and EP features of reciprocating SVT at rest and during exercise and to determine the factors related to syncope during high adrenergic tone.Group A = SVT, palpitationsGroup B = SVT near syncopeInduced SVT via esoph pacing in both groups.AVRT faster when induced during exerciseRate of SVT unrelated to sx of pre-syncopeGoyal R1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Goyal</Author><Year>1996</Year><RecNum>36</RecNum><IDText>Comparison of the ages of tachycardia onset in patients with atrioventricular nodal reentrant tachycardia and accessory pathway-mediated tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>36</Ref_ID><Title_Primary>Comparison of the ages of tachycardia onset in patients with atrioventricular nodal reentrant tachycardia and accessory pathway-mediated tachycardia</Title_Primary><Authors_Primary>Goyal,R.</Authors_Primary><Authors_Primary>Zivin,A.</Authors_Primary><Authors_Primary>Souza,J.</Authors_Primary><Authors_Primary>Shaikh,S.A.</Authors_Primary><Authors_Primary>Harvey,M.</Authors_Primary><Authors_Primary>Bogun,F.</Authors_Primary><Authors_Primary>Daoud,E.</Authors_Primary><Authors_Primary>Man,K.C.</Authors_Primary><Authors_Primary>Strickberger,S.A.</Authors_Primary><Authors_Primary>Morady,F.</Authors_Primary><Date_Primary>1996/10</Date_Primary><Keywords>Adult</Keywords><Keywords>Age of Onset</Keywords><Keywords>epidemiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>765</Start_Page><End_Page>767</End_Page><Periodical>Am Heart J</Periodical><Volume>132</Volume><Issue>4</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Misc_3>S0002-8703(96)90308-7</Misc_3><Address>Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA</Address><Web_URL>PM:8831363</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(6)88313631996;132:765-7Observational519 231 AVNRT288 AVRTAVNRT or AVRTAssessment of age of onsetThe mean age of sx onset was 32±18 y for AVNRT and 23±14 y for AP-mediated tachycardia. A significantly greater proportion of pts w/ AVNRT had the initial onset of sxs after the age of 20 y (AV nodal reen- trant tachycardia, 67% vs. AP, 41% (p<0.001)There is a different mean age of sx onset for pts w/ AVNRT and AP-mediated tachycardia.Abe H1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFiZTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFiZTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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 EN.CITE.DATA (7)9392809Prospective study of pts w/ SVT N=3213 AVNRT4 atrial flutter15 AVRT32 consecutive pts w/ PSVTHypothesis was that pts w/ AVNRT would have more sx of diuresis because of higher right pressureIncreased diuresis in 12/13 (92%) of pts w/ AVNRT; 2/15 (13%) AVRT; and 1/4 atrial flutter w/ 2:1 AV conduction. Measured right atrial pressure and plasma ANP in 14 of 32 pts. RA pressure higher in AVNRT compared to the other tachycardias (16 vs. 5; p<0.01) and ANP levels also higher (215 vs. 63; p<0.001) Sx of diuresis more common w/ AVNRT. The higher secretion of ANP may be the mechanism because there is a linear relationship between plasma ANP levels and atrial pressure Lessmeier TJ1997 ADDIN REFMGR.CITE <Refman><Cite><Author>Lessmeier</Author><Year>1997</Year><RecNum>43</RecNum><IDText>Unrecognized paroxysmal supraventricular tachycardia. Potential for misdiagnosis as panic disorder</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>43</Ref_ID><Title_Primary>Unrecognized paroxysmal supraventricular tachycardia. Potential for misdiagnosis as panic disorder</Title_Primary><Authors_Primary>Lessmeier,T.J.</Authors_Primary><Authors_Primary>Gamperling,D.</Authors_Primary><Authors_Primary>Johnson-Liddon,V.</Authors_Primary><Authors_Primary>Fromm,B.S.</Authors_Primary><Authors_Primary>Steinman,R.T.</Authors_Primary><Authors_Primary>Meissner,M.D.</Authors_Primary><Authors_Primary>Lehmann,M.H.</Authors_Primary><Date_Primary>1997/3/10</Date_Primary><Keywords>diagnosis</Keywords><Keywords>Diagnosis,Differential</Keywords><Keywords>Diagnostic Errors</Keywords><Keywords>Electrocardiography,Ambulatory</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Panic Disorder</Keywords><Keywords>physiopathology</Keywords><Keywords>Recurrence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>537</Start_Page><End_Page>543</End_Page><Periodical>Arch.Intern Med</Periodical><Volume>157</Volume><Issue>5</Issue><ISSN_ISBN>0003-9926</ISSN_ISBN><Address>Department of Internal Medicine, Wayne State University, Detroit, USA</Address><Web_URL>PM:9066458</Web_URL><ZZ_JournalFull><f name="System">Archives of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Arch.Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(8)9066458Retrospective survey119 consecutive ptsLimited to AVRT, AVNRTSystematically evaluate the potential for SVT to simulate panic disorderCriteria for panic disorder per DSM-IV were fulfilled in 67%. SVT unrecognized after initial medical evaluation in 59 (55%) including 41% of 32 w/ preexcitation. Physicians attributed sx to panic, anxiety orstress in 32 of the 59 (54%). SVT unrecognized a median of 3.3 yWomen more likely to be labeled w/ panic than men (65% vs. 32% p<0.04SVT diagnosed in 6 (9%) of 64 pts w/ Holters and 8 (47%) of 17 w/ event monitors (p=0.001)SVT can mimic panic disorders and the diagnosis is often delayed by inappropriate rhythm detection techniques or missed preexcitation. Unrecognized SVT often attributed to psychiatric conditions.Perhaps misdiagnosis happens in women more often due to miscategorization of “feeling” in survey Kalusche D1998 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbHVzY2hlPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbHVzY2hlPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN EN.CITE.DATA (9)9812187Observational395 pt w/ AVNRT85 were >65 yLimited to AVNRTMain objective was to analyze risks and outcomes of ablation, but they also characterized presenting sxsElderly patents (mean 70.4 y) more often had syncope or presyncope w/ AVNRT (43.2% vs. 29.8%; P=0.05); had more hospitalizations and emergency department visits because of their sx 56.8 vs. 39.5% p,0.05 even though the CL was longer in the elderly (368 vs. 325 msec; P=0.0001) Elderly pts have more sxs, ER visits, and hospitalizations despite slower tachycardias. (Outcomes of ablation were no different.)Orejarena LA1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Orejarena</Author><Year>1998</Year><RecNum>45</RecNum><IDText>Paroxysmal supraventricular tachycardia in the general population</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>45</Ref_ID><Title_Primary>Paroxysmal supraventricular tachycardia in the general population</Title_Primary><Authors_Primary>Orejarena,L.A.</Authors_Primary><Authors_Primary>Vidaillet,H.,Jr.</Authors_Primary><Authors_Primary>DeStefano,F.</Authors_Primary><Authors_Primary>Nordstrom,D.L.</Authors_Primary><Authors_Primary>Vierkant,R.A.</Authors_Primary><Authors_Primary>Smith,P.N.</Authors_Primary><Authors_Primary>Hayes,J.J.</Authors_Primary><Date_Primary>1998/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Child</Keywords><Keywords>Emergencies</Keywords><Keywords>epidemiology</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prevalence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Wisconsin</Keywords><Reprint>Not in File</Reprint><Start_Page>150</Start_Page><End_Page>157</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>31</Volume><Issue>1</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>S0735-1097(97)00422-1</Misc_3><Address>Marshfield Clinic and the Marshfield Medical Research Foundation, Wisconsin 54449, USA</Address><Web_URL>PM:9426034</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(10)9426034Population epidemiologic researchScreened 50,000Identified 1,763 w/ SVTLimited to PSVTStandard ECG criteria for PSVT were employed: 1) paroxysmal, 2) normal QRS complex configuration or preexisting bundle branch block, 3) variation in successive RR intervals ≤40 msec, 4) ventricular rate 120 bpm, 5) no evidence of AV dissociation, and 6) no identifiable P waves preceding the QRS complex during tachycardia. The aim was to determine the epidemiology and clinical significance of PSVT in the general population. The prevalence was 2.25/1,000 persons and the incidence was 35/100,000 person-ys (95% CI: 23-47).Those w/ lone PSVT were younger (mean 37 vs. 69 y; p<0.0002), had a faster PSVT heart rate (mean 186 vs. 155 bpm; p<0.0006) and were more likely to have their condition first documented in the emergency room (69% vs. 30%; p<0.0377). The onset of sxs occurred during the childbearing y in 58% of females w/ lone PSVT vs. 9% of females w/ other cardio- vascular disease (p<0.0272).21 incident pts (64%) had sxsconcordant w/ PSVT before initial ECG documentation.The probability of recurrence by the end of y 2 of f/u was 0.20 (95% CI: 0.06-0.35). There were no predictors of recurrence. For pts w/ a recurrence, all except one had their first recurrence w/in 12 mo of diagnosis and one had hemodynamic instability. 5 pts died during f/u, none due to PSVT Approximately 89,000 new cases/y and 570,000 persons w/ PSVT in the United States. Erdogan A2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVyZG9nYW48L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVyZG9nYW48L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (11)11785371Cohort survey748 pts who underwent ablation responded to a surveyLimited to AVNRTAnalyze the medical h/o pts w/ AVNRTInterval from onset of sx to ablation was 4.1 +/- 1.5 y. Mean age 55.4 female and 58.7 males. Only 6% had SHD. In females AVNRT appeared after age 50 in 16% and <age 20 in 18%. Women were more symptomatic. Women were more likely to delay ablation (average 7 y) (unknown whether this was due to personal preference or bias due to advice given)High rate of pt w/ AVNRT begin in an older stage of lifeFitzsimmons PJ2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Fitzsimmons</Author><Year>2001</Year><RecNum>34</RecNum><IDText>The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>34</Ref_ID><Title_Primary>The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years</Title_Primary><Authors_Primary>Fitzsimmons,P.J.</Authors_Primary><Authors_Primary>McWhirter,P.D.</Authors_Primary><Authors_Primary>Peterson,D.W.</Authors_Primary><Authors_Primary>Kruyer,W.B.</Authors_Primary><Date_Primary>2001/9</Date_Primary><Keywords>Adult</Keywords><Keywords>Cohort Studies</Keywords><Keywords>Death,Sudden,Cardiac</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Military Personnel</Keywords><Keywords>pathology</Keywords><Keywords>Patient Selection</Keywords><Keywords>Questionnaires</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Telephone</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>530</Start_Page><End_Page>536</End_Page><Periodical>Am Heart J</Periodical><Volume>142</Volume><Issue>3</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Misc_3>S0002-8703(01)18940-4;10.1067/mhj.2001.117779</Misc_3><Address>Internal Medicine Branch, Aeromedical Consultation Service, US Air Force School of Aerospace Medcine, Brooks AFB, Tex., USA</Address><Web_URL>PM:11526369</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(12)11526369Retrospective review238 aviatorsFocused on manifest WPWReport the natural h/o WPW in a nontertiary care population for the development of SCD and SVT232 males, 6 womenmedian age 35 (17-56)11.7% had sx suggestive of SVT. 1 had syncope and 12 had near syncope. During f/u SVT occurred in 20.6%. SCD in 1 (0.02%)Incidence of SVT is 1% per pt y. SCD risk lowHamdan MH2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Hamdan</Author><Year>2001</Year><RecNum>37</RecNum><IDText>Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>37</Ref_ID><Title_Primary>Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response</Title_Primary><Authors_Primary>Hamdan,M.H.</Authors_Primary><Authors_Primary>Zagrodzky,J.D.</Authors_Primary><Authors_Primary>Page,R.L.</Authors_Primary><Authors_Primary>Wasmund,S.L.</Authors_Primary><Authors_Primary>Sheehan,C.J.</Authors_Primary><Authors_Primary>Adamson,M.M.</Authors_Primary><Authors_Primary>Joglar,J.A.</Authors_Primary><Authors_Primary>Smith,M.L.</Authors_Primary><Date_Primary>2001/1/2</Date_Primary><Keywords>Baroreflex</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Hemodynamics</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Pacemaker,Artificial</Keywords><Keywords>Peroneal Nerve</Keywords><Keywords>physiopathology</Keywords><Keywords>Regression Analysis</Keywords><Keywords>Sympathetic Nervous System</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>96</Start_Page><End_Page>101</End_Page><Periodical>Circulation</Periodical><Volume>103</Volume><Issue>1</Issue><ISSN_ISBN>1524-4539</ISSN_ISBN><Address>University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA. Hamdan@ryburn.swmed.edu44195</Address><Web_URL>PM:11136692</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(13)11136692Prospective analysis112112 pts w/ pacemakersExamine effect of atrial timing during simulated tachycardia on hemodynamic and neural responses.Decrease in BP greatest w/ simultaneous pacing, less w/ short RP, and least w/ long RPIncrease in CVP followed same trendSNA% increased w/ all three, but most pronounced w/ simultaneous AV and most w/ short RPArterial baroreflex SNA correlated modestly w/ change in CVPSNA increases during all pacing modesDecrease in BP and pulse pressure, which is directly related to the tachycardia rate, cardiac function, and AV synchrony. At any given rate, the timing of atrial systole has been shown to alter the hemodynamic response.Razavi M2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Razavi</Author><Year>2005</Year><RecNum>46</RecNum><IDText>Acute blood pressure changes after the onset of atrioventricular nodal reentrant tachycardia: a time-course analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>46</Ref_ID><Title_Primary>Acute blood pressure changes after the onset of atrioventricular nodal reentrant tachycardia: a time-course analysis</Title_Primary><Authors_Primary>Razavi,M.</Authors_Primary><Authors_Primary>Luria,D.M.</Authors_Primary><Authors_Primary>Jahangir,A.</Authors_Primary><Authors_Primary>Hodge,D.O.</Authors_Primary><Authors_Primary>Low,P.A.</Authors_Primary><Authors_Primary>Shen,W.K.</Authors_Primary><Date_Primary>2005/10</Date_Primary><Keywords>Adult</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiologic Techniques,Cardiac</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Posture</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Time Factors</Keywords><Reprint>Not in File</Reprint><Start_Page>1037</Start_Page><End_Page>1040</End_Page><Periodical>J Cardiovasc Electrophysiol.</Periodical><Volume>16</Volume><Issue>10</Issue><ISSN_ISBN>1045-3873</ISSN_ISBN><Misc_3>JCE40731;10.1111/j.1540-8167.2005.40731.x</Misc_3><Address>Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA</Address><Web_URL>PM:16191112</Web_URL><ZZ_JournalFull><f name="System">Journal of cardiovascular electrophysiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Cardiovasc Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(14)16191112ObservationalN=17AVNRTChange in BP over timeBP decreased immediately after AVNRT initiation, w/ gradual recovery during the first 30 sec from 71.9±16.5 mm Hg to 86±13.8 mm Hg, p<0.01. When upright, the mean BP time course was similar, but mean BP recovery during AVNRT was slowerA short AV interval is associated w/ a greater mean BP decrease at the onset of tachycardia. These observations may explain clinical sxs immediately after the onset of AVNRTWalfidsson U2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Walfridsson</Author><Year>2005</Year><RecNum>48</RecNum><IDText>The impact of supraventricular tachycardias on driving ability in patients referred for radiofrequency catheter ablation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>48</Ref_ID><Title_Primary>The impact of supraventricular tachycardias on driving ability in patients referred for radiofrequency catheter ablation</Title_Primary><Authors_Primary>Walfridsson,U.</Authors_Primary><Authors_Primary>Walfridsson,H.</Authors_Primary><Date_Primary>2005/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Automobile Driving</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Chi-Square Distribution</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Interviews as Topic</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Statistics,Nonparametric</Keywords><Keywords>surgery</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>191</Start_Page><End_Page>195</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>28</Volume><Issue>3</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Misc_3>PACE9753;10.1111/j.1540-8159.2005.09753.x</Misc_3><Address>Department of Cardiology, University Hospital, Linkoping, Sweden. ulla.walfridsson@lio.se</Address><Web_URL>PM:15733177</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(15)15733177Survey of pts referred for ablation301 pts226 active driversLimited to AVRT and AVNRTEvaluate the sx in pt w/ SVT and impact on drivingIn 226 active drivers, fatigue 77%, dizziness 47%, diaphoresis 52%, near syncope 50%, and syncope14% reported w/ SVT. Women had more sxs for each category. 57% experienced SVT while driving and 42% had to stop because of it (during that episode). 24 pts considered SVT an obstacle to driving. SVT is frequent while driving and can be associated w/ near syncope or syncope. Women seemed to have worse sxs. Pts w/ near syncope or syncope more likely to consider SVT an obstacle to drivingDrago F2006 ADDIN REFMGR.CITE <Refman><Cite><Author>Drago</Author><Year>2006</Year><RecNum>31</RecNum><IDText>Atrioventricular nodal reentrant tachycardia in children</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>31</Ref_ID><Title_Primary>Atrioventricular nodal reentrant tachycardia in children</Title_Primary><Authors_Primary>Drago,F.</Authors_Primary><Authors_Primary>Grutter,G.</Authors_Primary><Authors_Primary>Silvetti,M.S.</Authors_Primary><Authors_Primary>De,Santis A.</Authors_Primary><Authors_Primary>Di,Ciommo,V</Authors_Primary><Date_Primary>2006/7</Date_Primary><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Body Surface Potential Mapping</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiologic Techniques,Cardiac</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>pathology</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Recurrence</Keywords><Keywords>Severity of Illness Index</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>454</Start_Page><End_Page>459</End_Page><Periodical>Pediatr.Cardiol</Periodical><Volume>27</Volume><Issue>4</Issue><ISSN_ISBN>0172-0643</ISSN_ISBN><Misc_3>10.1007/s00246-006-1279-2</Misc_3><Address>Department of Pediatric Cardiology, Bambino Gesu Hospital, P.zza Sant'Onofiro, 400165 Rome, Italy. drago@</Address><Web_URL>PM:16835801</Web_URL><ZZ_JournalFull><f name="System">Pediatric cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pediatr.Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(16)16835801Observational62 childrenLimited to AVNRT. Determine whether severity of sxs was related to EP characteristicsWhen pts w/ severe sxs were compared to those w/ mild sxs there was no difference in inducibility, CL of AVNRT, or the ERPs of the fast and slow pathways The severity of sxs was not related to EP characteristics. -Although this study focused on children, the results are probably applicable to adultsGonzalez-Torrecilla E2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbnphbGV6LVRvcnJlY2lsbGE8L0F1dGhvcj48WWVhcj4y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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbnphbGV6LVRvcnJlY2lsbGE8L0F1dGhvcj48WWVhcj4y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ADDIN EN.CITE.DATA (17)19539146Prospective analysis370 consecutive pts who underwent EP studyAVRNT 262 (23 atypical)ORT 108Excluded manifest preexcitationAssess the independent predictive contribution to the ECG of clinical variables to distinguish major forms of SVT370 consecutive ptsECG interpreted by 2 independent observersAVNRT more likely to be female, older age of onset (>30)Correct ECG interpretation more frequent in the AVRT groupRapid pounding in the neck more common w/ AVNRT (51% vs. 25%)Age at the onset of sxs, sensation of rapid regular pounding in the neck during tachycardia, and female sex are the only significant clinical variablesLaurent G2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhdXJlbnQ8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhdXJlbnQ8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (18)18775049Mechanism of sx in SVT not understood. They evaluated VA timingSurvey included 152 pts w/ AVNRT and 80 w/ AVRTHemodynamic studies on 18 w/ AVRT and AVNRT326 pts w/ a variety of clinically documented tachycardias (AVNRT, AVRT, VT, atrial flutter, AF completed a brief self-administered questionnaire regarding the occurrence of 5 sxs: “neck pounding,” chest pounding, palpitations, “shirt flapping,” and dizziness. This paper focuses on AVRTMeasured left atrial pressure during AVRT and simulated AVRT and AVNRT by the timing of pacing the atria and ventricles. Sx of “shirt flapping” and “neck pounding” occur more frequently in AVNRT. Left atrial contractions during AV valve closure increase left atrial pressure and may explain the differences in sx between AVNRT and AVRT. Other sxs were about the same (chest pounding, palpitations, dizziness)Arterial pressures were significantly lower and left atrial pressures were significantly higher during native AVRT, simulated AVRT and AVNRT compared w/ sinus rhythm. Simulated AVRT created similar hemodynamic conditions as seen during native AVRT. Simulated AVNRT produced significantly higher left atrial pressure (peak and mean) than simulated AVRT.The sx of “shirt flapping” appears to be associated w/ pulsatile reversed flow in the pulmonary veins due to left atrial contraction against closed MV and is more common w/ AVNRTWalfridsson U2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbGZyaWRzc29uPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh
cj48UmVjTnVtPjQ5PC9SZWNOdW0+PElEVGV4dD5Xb2xmZi1QYXJraW5zb24tV2hpdGUgc3luZHJv
bWUgYW5kIGF0cmlvdmVudHJpY3VsYXIgbm9kYWwgcmUtZW50cnkgdGFjaHljYXJkaWEgaW4gYSBT
d2VkaXNoIHBvcHVsYXRpb246IGNvbnNlcXVlbmNlcyBvbiBoZWFsdGgtcmVsYXRlZCBxdWFsaXR5
IG9mIGxpZmU8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5h
bDwvUmVmX1R5cGU+PFJlZl9JRD40OTwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PldvbGZmLVBhcmtp
bnNvbi1XaGl0ZSBzeW5kcm9tZSBhbmQgYXRyaW92ZW50cmljdWxhciBub2RhbCByZS1lbnRyeSB0
YWNoeWNhcmRpYSBpbiBhIFN3ZWRpc2ggcG9wdWxhdGlvbjogY29uc2VxdWVuY2VzIG9uIGhlYWx0
aC1yZWxhdGVkIHF1YWxpdHkgb2YgbGlmZTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PldhbGZyaWRzc29uLFUuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TdHJvbWJl
cmcsQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkphbnpvbixNLjwvQXV0aG9y
c19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+V2FsZnJpZHNzb24sSC48L0F1dGhvcnNfUHJpbWFy
eT48RGF0ZV9QcmltYXJ5PjIwMDkvMTA8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QWR1bHQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BZ2UgRGlzdHJpYnV0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0
aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5Db21vcmJpZGl0eTwvS2V5d29yZHM+
PEtleXdvcmRzPmRpYWdub3NpczwvS2V5d29yZHM+PEtleXdvcmRzPmVwaWRlbWlvbG9neTwvS2V5
d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29y
ZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48
S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5QcmV2YWxlbmNlPC9LZXl3
b3Jkcz48S2V5d29yZHM+UXVhbGl0eSBvZiBMaWZlPC9LZXl3b3Jkcz48S2V5d29yZHM+U2V4IERp
c3RyaWJ1dGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jk
cz5Td2VkZW48L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdv
cmRzPlRhY2h5Y2FyZGlhLEF0cmlvdmVudHJpY3VsYXIgTm9kYWwgUmVlbnRyeTwvS2V5d29yZHM+
PEtleXdvcmRzPldvbGZmLVBhcmtpbnNvbi1XaGl0ZSBTeW5kcm9tZTwvS2V5d29yZHM+PFJlcHJp
bnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+MTI5OTwvU3RhcnRfUGFnZT48RW5k
X1BhZ2U+MTMwNjwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+UGFjaW5nIENsaW4uRWxlY3Ryb3BoeXNp
b2wuPC9QZXJpb2RpY2FsPjxWb2x1bWU+MzI8L1ZvbHVtZT48SXNzdWU+MTA8L0lzc3VlPjxJU1NO
X0lTQk4+MTU0MC04MTU5PC9JU1NOX0lTQk4+PE1pc2NfMz5QQUNFMjQ3NjsxMC4xMTExL2ouMTU0
MC04MTU5LjIwMDkuMDI0NzYueDwvTWlzY18zPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgTWVkaWNh
bCBhbmQgSGVhbHRoIFNjaWVuY2VzLCBEaXZpc2lvbiBvZiBOdXJzaW5nIFNjaWVuY2UsIExpbmtv
cGluZyBVbml2ZXJzaXR5LCBMaW5rb3BpbmcsIFN3ZWRlbi4gdWxsYS53YWxmcmlkc3NvbkBsaW8u
c2U8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTk3MDI2MDA8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxs
PjxmIG5hbWU9IlN5c3RlbSI+UGFjaW5nIGFuZCBjbGluaWNhbCBlbGVjdHJvcGh5c2lvbG9neSA6
IFBBQ0U8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJT
eXN0ZW0iPlBhY2luZyBDbGluLkVsZWN0cm9waHlzaW9sLjwvZj48L1paX0pvdXJuYWxTdGRBYmJy
ZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbGZyaWRzc29uPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh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 EN.CITE.DATA (19)19702600QOL survey97 AVNRT79 AVRTFocused on pts w/ AVRT and AVNRTQOL scoresQOL scores were lower for pts w/ AVNRT compared to AVRT. Scores were affected by occurrence more than once a mo, arrhythmia duration, and whether sx occurred not only during exercise but also at rest. The main conclusion was that QOL scores may direct therapy. Kesek M2011 ADDIN REFMGR.CITE <Refman><Cite><Author>Kesek</Author><Year>2011</Year><RecNum>39</RecNum><IDText>Symptomatic improvement after catheter ablation of supraventricular tachycardia measured by the arrhythmia-specific questionnaire U22</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>39</Ref_ID><Title_Primary>Symptomatic improvement after catheter ablation of supraventricular tachycardia measured by the arrhythmia-specific questionnaire U22</Title_Primary><Authors_Primary>Kesek,M.</Authors_Primary><Authors_Primary>Ronn,F.</Authors_Primary><Authors_Primary>Tollefsen,T.</Authors_Primary><Authors_Primary>Hoglund,N.</Authors_Primary><Authors_Primary>Naslund,U.</Authors_Primary><Authors_Primary>Jensen,S.M.</Authors_Primary><Date_Primary>2011/3</Date_Primary><Keywords>Accessory Atrioventricular Bundle</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Questionnaires</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>52</Start_Page><End_Page>59</End_Page><Periodical>Ups.J Med Sci.</Periodical><Volume>116</Volume><Issue>1</Issue><User_Def_5>PMC3039761</User_Def_5><ISSN_ISBN>2000-1967</ISSN_ISBN><Misc_3>10.3109/03009734.2010.517875</Misc_3><Address>Department of Cardiology, Heart Centre, University Hospital, Umea, Sweden. milos.kesek@medicin.umu.se</Address><Web_URL>PM:21077786</Web_URL><ZZ_JournalFull><f name="System">Upsala journal of medical sciences</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ups.J Med Sci.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(20)21077786Assessment of the U22 survey for clinical sxs before and after ablation156 pts who underwent ablation of SVTAVNRT and AVRTQOL scoresMean age 43.9 AVNRT vs. 57.1 AVRTMen 65% AVRT and 38% AVNRT71% took medications prior to ablationQOL scores using either the U22 or SF-36 improved after ablation. Cain N2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Cain</Author><Year>2013</Year><RecNum>30</RecNum><IDText>Natural history of Wolff-Parkinson-White syndrome diagnosed in childhood</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>30</Ref_ID><Title_Primary>Natural history of Wolff-Parkinson-White syndrome diagnosed in childhood</Title_Primary><Authors_Primary>Cain,N.</Authors_Primary><Authors_Primary>Irving,C.</Authors_Primary><Authors_Primary>Webber,S.</Authors_Primary><Authors_Primary>Beerman,L.</Authors_Primary><Authors_Primary>Arora,G.</Authors_Primary><Date_Primary>2013/10/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Asymptomatic Diseases</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>complications</Keywords><Keywords>Death,Sudden,Cardiac</Keywords><Keywords>diagnosis</Keywords><Keywords>Disease Progression</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>mortality</Keywords><Keywords>physiopathology</Keywords><Keywords>Remission,Spontaneous</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>961</Start_Page><End_Page>965</End_Page><Periodical>Am J Cardiol</Periodical><Volume>112</Volume><Issue>7</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(13)01233-2;10.1016/j.amjcard.2013.05.035</Misc_3><Address>Medical University of South Carolina, Charleston, South Carolina. Electronic address: cainn@musc.edu</Address><Web_URL>PM:23827401</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(21)23827401Retrospective review446 pts Pts <21 w/ WPW (median age of diagnosis was 7y)Modes of presentationModes of presentation included SVT (38%), palpitations (22%), chest pain (5%), syncope (4%), AF (0.4%), sudden death (0.2%), and incidental findings (26%); data were unavailable in 4% 64% had sxs at presentation, and an additional 20% developed sxs during f/u. There were 6 sudden deaths (1.3%), w/ an overall incidence of 1.1 per 1,000 pt-y in pts w/ structurally normal hearts and 27 per 1,000 pt-y in pts w/ associated heart disease.Although this was a pediatric study, it provides historical data that we can expect adults to describe. Maryniak A2013 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcnluaWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcnluaWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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=
ADDIN EN.CITE.DATA (22)23129107Retrospective analysis113AVRT or AVNRT pts (9-13 y)Evaluated cognitive and emotional development in a group of children and adolescents w/ AVRT and AVNRT.Mean age AVRT 8Meant age AVNRT 1132% had hx syncope, more frequently w/ AVRT (37.5% vs. 24%; p=0.16)Deficiencies in cognitive function were prevalent.Anxiety levels increase w/ the appearance of sxs. Both AVRT and AVNRT in childhood and adolescence can have a negative impact on cognitive and emotional development. Pts experiencing AVRT in the first y of life are likely to exhibit particularly severe deficits in cognitive function, including memory.AF indicates atrial fibrillation; AP, accessory pathway; ANP, atrial natriuretic peptide; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; AT, atrial tachycardia; BP, blood pressure; bpm, beats per minute; CL, cycle length; CVP, central venous pressure; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders-IV; ECG, echocardiogram; EP, electrophysiological; ERP, effective refractory period; f/u, follow up; h/o, history of; MV, ??; ORT, orthodromic reentrant tachycardia; PAP, pulmonary arterial pressure; PSVT, paroxysmal supraventricular tachycardia; pt, patient; QOL, quality of life; RA, right arterial; SCD, sudden cardiac death; SF-36, Short-Form (36) Healt Survey; SHD, structural heart disease; SNA, sympathetic nerve activity; SVR, systemic valvular resistance; SVT, supraventricular tachycardia; sx, symptom; sx, symptom; U22 questionnaire, Umea 22 Arrhythmia Questions; VA, ventricular arrhythmia; VT, ventricular tachycardia; w/, with; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 2. Randomized Trials Comparing Principles of Acute and Chronic Therapy – Section 2.4 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsMauritson1982 ADDIN REFMGR.CITE <Refman><Cite><Author>Mauritson</Author><Year>1982</Year><RecNum>7</RecNum><IDText>Oral verapamil for paroxysmal supraventricular tachycardia: a long-term, double-blind randomized trial</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>7</Ref_ID><Title_Primary>Oral verapamil for paroxysmal supraventricular tachycardia: a long-term, double-blind randomized trial</Title_Primary><Authors_Primary>Mauritson,D.R.</Authors_Primary><Authors_Primary>Winniford,M.D.</Authors_Primary><Authors_Primary>Walker,W.S.</Authors_Primary><Authors_Primary>Rude,R.E.</Authors_Primary><Authors_Primary>Cary,J.R.</Authors_Primary><Authors_Primary>Hillis,L.D.</Authors_Primary><Date_Primary>1982/4</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>409</Start_Page><End_Page>412</End_Page><Periodical>Ann Intern Med</Periodical><Volume>96</Volume><Issue>4</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Web_URL>PM:7065555</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(23) 7065555Effectiveness and safety of oral verapamil11Verapamil 240 mg/d followed by 480 mg/d (n=11)PlaceboSymptomatic PSVT, ≥2 episodes/mo, ascertained by ECGAVNRT(n=7)AVRT(n=2 w/ WPW, n=3 w/ concealed AP)CHF, severe hypertension, hypotension, VHD or CHD, renal/hepatic failure, SSS, AV block, atrial flutter, AF, AADsEpisodes/d (diary, Holter)Verapamil 0.1±0.1 ,0.3 ±0.5Placebo 0.3±0.3 ,0.7 ±0.7Duration(min) (diary, Holter)Verapamil 3±3 ,1±2Placebo 27±5 ,67±111Minor AEs in 6 pts on verapamil5 pts required a total of 35 cardioversions for sustained tachycardia, 2 during verapamil, 33 during placebo (p<0.001)Programmed electrical stimulation performed at end of study to induce tachycardia. Caused sustained tachycardia in 9 on placebo, 2 on verapamil (p<0.01) N/Ap<0.05 for primary endpointsOral verapamil safe and effective.Small sample size.Unclear which pt withdrew, so numbers of AVNRT vs. AVRT may be similar (i.e., 6 vs. 5). Winniford1984 ADDIN REFMGR.CITE <Refman><Cite><Author>Winniford</Author><Year>1984</Year><RecNum>8</RecNum><IDText>Long-term therapy of paroxysmal supraventricular tachycardia: a randomized, double-blind comparison of digoxin, propranolol and verapamil</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>8</Ref_ID><Title_Primary>Long-term therapy of paroxysmal supraventricular tachycardia: a randomized, double-blind comparison of digoxin, propranolol and verapamil</Title_Primary><Authors_Primary>Winniford,M.D.</Authors_Primary><Authors_Primary>Fulton,K.L.</Authors_Primary><Authors_Primary>Hillis,L.D.</Authors_Primary><Date_Primary>1984/11/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Clinical Trials as Topic</Keywords><Keywords>Digoxin</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Propranolol</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>1138</Start_Page><End_Page>1139</End_Page><Periodical>Am J Cardiol</Periodical><Volume>54</Volume><Issue>8</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Web_URL>PM:6388299</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(24)6388299Effect of AV nodal blockers for long-term therapy of PSVT11One mo of:Digoxin 0.375 mg/dPropranolol 240 mg/dVerapamil 480 mg/dDirect comparison between all 3, w/ 1 wk of placebo washoutSymptomatic PSVT, ≥2 episodes/mo, ascertained by ECGECG evidence of preexcitationEpisodes and duration (ascertained by diary and weekly 24 h Holter), adverse effects, SDCs of each drugEpisodes/wk (diary, Holter)Digoxin 2.3±3.1, 1.9±2.9Propranolol 1.5±2.3 ,0.2±0.6Verapamil 2.9±5.7 ,0.6 ±1.6Duration(min) (diary, Holter)Digoxin 75±164, 47±157Propranolol 60±112 ,1±1Verapamil 56±148 ,1±1Mild side effects in 3/11 pts w/ digoxin and propranolol, and 5/11 w/ verapamil. All SDCs w/in normal reference range.?N/A?p=NSOnly verapamil had been studied in RCT prior to this (above) and given its proven efficacy, authors felt no need for placebo. Small series of pts.Unclear mechanism of PSVT (authors speculate all pts w/ AVRNT or oral rehydration therapy w/ concealed conduction. Anderson1986 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZGVyc29uPC9BdXRob3I+PFllYXI+MTk4NjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZGVyc29uPC9BdXRob3I+PFllYXI+MTk4NjwvWWVhcj48
UmVjTnVtPjU8L1JlY051bT48SURUZXh0PkNvbXBhcmlzb24gb2YgdGhlIGVmZmljYWN5IGFuZCBz
YWZldHkgb2YgZXNtb2xvbCwgYSBzaG9ydC1hY3RpbmcgYmV0YSBibG9ja2VyLCB3aXRoIHBsYWNl
Ym8gaW4gdGhlIHRyZWF0bWVudCBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5YXJyaHl0aG1pYXMu
IFRoZSBFc21vbG9sIHZzIFBsYWNlYm8gTXVsdGljZW50ZXIgU3R1ZHkgR3JvdXA8L0lEVGV4dD48
TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9J
RD41PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+Q29tcGFyaXNvbiBvZiB0aGUgZWZmaWNhY3kgYW5k
IHNhZmV0eSBvZiBlc21vbG9sLCBhIHNob3J0LWFjdGluZyBiZXRhIGJsb2NrZXIsIHdpdGggcGxh
Y2VibyBpbiB0aGUgdHJlYXRtZW50IG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHlhcnJoeXRobWlh
cy4gVGhlIEVzbW9sb2wgdnMgUGxhY2VibyBNdWx0aWNlbnRlciBTdHVkeSBHcm91cDwvVGl0bGVf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkFuZGVyc29uLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5CbGFuc2tpLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5CeXJkLFIuQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkRhcyxHLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RW5nbGVyLFIuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5MYWRkdSxBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+TGVlLFIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5SYWpmZXIsUy48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNjaHJvZWRlcixKLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+U3RlY2ssSi5ELjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+LjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk4Ni8xPC9EYXRlX1By
aW1hcnk+PEtleXdvcmRzPkFkcmVuZXJnaWMgYmV0YS1BbnRhZ29uaXN0czwvS2V5d29yZHM+PEtl
eXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jk
cz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFycmh5dGhtaWFzLENhcmRpYWM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5DbGluaWNhbCBUcmlhbHMgYXMgVG9waWM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5jb21wbGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+RG91YmxlLUJsaW5kIE1l
dGhvZDwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRz
PkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jk
cz5IZWFydCBWZW50cmljbGVzPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48
S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPlByb3Bhbm9sYW1pbmVzPC9LZXl3b3Jk
cz48S2V5d29yZHM+UmFuZG9tIEFsbG9jYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNh
cmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PFJlcHJp
bnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+NDI8L1N0YXJ0X1BhZ2U+PEVuZF9Q
YWdlPjQ4PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5BbSBIZWFydCBKPC9QZXJpb2RpY2FsPjxWb2x1
bWU+MTExPC9Wb2x1bWU+PElzc3VlPjE8L0lzc3VlPjxJU1NOX0lTQk4+MDAwMi04NzAzPC9JU1NO
X0lTQk4+PFdlYl9VUkw+UE06Mjg2ODY0NTwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFt
ZT0iU3lzdGVtIj5BbWVyaWNhbiBoZWFydCBqb3VybmFsPC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpa
X0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5BbSBIZWFydCBKPC9mPjwvWlpfSm91
cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0
ZT48L1JlZm1hbj5=
ADDIN EN.CITE.DATA (25)2868645Efficacy of esmolol in treatment of PSVT71Multicenter, double-blind, partial-crossover studyEsmolol (n=36)Placebo (n=35)?“SVT” (HR>120)Note: AVNRT in 18% of subjectsVHD, AV block, SSS, significant electrolyteabnormality,precluding treatment w/ beta blockade, bronchialasthma, ventricular arrhythmias requiring drug therapy,cardiogenic shock, CHF (NYHA III-IV), renal or hepatic dysfunction, drug or alcohol abuse, on other beta-adrenergic blockers or calcium channelblockers w/in two half-lives of study entryTherapeutic response: ≥20% reduction in HR, HR<100 bpm, or conversion to NSR.Therapeutic response to esmolol during the initial treatment period (72%) similar when esmolol was given as a second agent4 pts (6%) converted to NSRIn the 80% therapeutic response lost w/in 30 min following discontinuation of esmolol infusionHypotension which occurred in12% on esmolol, 2% w/ placebo.N/Ap=NSRapid onset and short ofaction of esmolol offer safe, effective therapy for acute treatment of pts w/ PSVT. Low numbers of pts w/ AVNRT.Henthorn1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Henthorn</Author><Year>1991</Year><RecNum>11</RecNum><IDText>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>11</Ref_ID><Title_Primary>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Henthorn,R.W.</Authors_Primary><Authors_Primary>Waldo,A.L.</Authors_Primary><Authors_Primary>Anderson,J.L.</Authors_Primary><Authors_Primary>Gilbert,E.M.</Authors_Primary><Authors_Primary>Alpert,B.L.</Authors_Primary><Authors_Primary>Bhandari,A.K.</Authors_Primary><Authors_Primary>Hawkinson,R.W.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Date_Primary>1991/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>Drug Administration Schedule</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>119</Start_Page><End_Page>125</End_Page><Periodical>Circulation</Periodical><Volume>83</Volume><Issue>1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Division of Cardiology, Christ Hospital, Cincinnati, Ohio 45219</Address><Web_URL>PM:1898640</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(26)1898640Flecainide for treatment of symptomatic PSVT (≥2 episodes)348-wk crossover (after four episodes of PSVT or end of treatment period)?Flecainide(n=34)Placebo(n=34)PSVT Syncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) Freedom from symptomatic PSVT at 60 d:79% events vs. 15% (p<0.001)Flecainide slowed symptomatic PSVT HR to 143±12 bpm from 178 ±12 on placebo in 7 pts who had events in the placebo and flecainide treatment phases(p<0.02)Significantly more side effects w/ flecainide (p<0.05)Flecainide vs. placebo:Recurrence:8/34 vs. 29/34 (p<0.001).Median time to first event: 55 vs. 11 d (p<0.001)Median interval between episodes >55 vs. 12 d(p<0.001)?N/ADespite participationof 19 medical centers, only 34 pts completed entire protocol and provided analyzable data.All pts tolerated flecainide, limiting generalizability.Transtelephonic monitoring does not permit assessment of proarrhythmia.6/34 w/ AVNRT, confirmed by EP study, and 18/34 w/ unknown mechanism.Pritchett1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pritchett</Author><Year>1991</Year><RecNum>10</RecNum><IDText>Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>10</Ref_ID><Title_Primary>Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>DaTorre,S.D.</Authors_Primary><Authors_Primary>Platt,M.L.</Authors_Primary><Authors_Primary>McCarville,S.E.</Authors_Primary><Authors_Primary>Hougham,A.J.</Authors_Primary><Date_Primary>1991/2</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>297</Start_Page><End_Page>303</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>17</Volume><Issue>2</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Address>Duke University Medical Center, Durham, North Carolina 27710</Address><Web_URL>PM:1899432</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(27) 1899432 Dose-response efficacy of flecainide in patents w/ PSVT, PAF, paroxysmal atrial flutter42Flecainide given in ascending order (2550100150 mg bid)PSVT(n=14, Group 1)PAF or parosysmal atrial flutter(n=28, Group 2)Placebo inserted at random (alternating w/ flecainide) at 30 d intervalsPSVT, PAF, or paroxysmal atrial flutterSyncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) .Among 14 pts in Group 1 (PSVT) who qualified for efficacy analysis, 4 (29%) had no tachycardia while taking placebo. Number w/ no tachycardia increased w/ progressively larger flecainide doses; w/ the 150 mg twice daily dose, 12 (86%) of 14 pts had no tachycardia (p<0.01 for overall differences among all treatments).Noncardiac adverse experiences were leading cause of premature study discontinuation during flecainide treatment periods (5 pts in Group 1 and 6 pts in Group 2).N/AN/ASmall sample size, short treatment period. Pritchett1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pritchett</Author><Year>1991</Year><RecNum>9</RecNum><IDText>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>9</Ref_ID><Title_Primary>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</Title_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>McCarthy,E.A.</Authors_Primary><Authors_Primary>Wilkinson,W.E.</Authors_Primary><Date_Primary>1991/4/1</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Statistics as Topic</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>539</Start_Page><End_Page>544</End_Page><Periodical>Ann Intern Med</Periodical><Volume>114</Volume><Issue>7</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Address>Duke University Medical Center, Durham, North Carolina</Address><Web_URL>PM:2001087</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(28) 2001087Oral propafenone to prevent symptomatic PSVTRandomized, double-blind, placebo-controlled, crossover phase, w/ each treatment period lasting up to 60 d.23Propafenone (n=23)Placebo(n=23)PSVT(n=14) PAF(n=9)Angina during tachycardia, pulmonary edema, neurologicsxs. PAF w/ WPW, on AADsCompared w/ placebo, propafenone caused an increase in time to first recurrence of arrhythmia (p=0.004)PSVT:p=0.03PAF:p=0.06.Cardiac AEs occurred only in pts w/ PAF (9/11): 2 w/ prolonged episode of AF, 1 w/ atrial flutter w/ a mean ventricularrate of 263 bpm recorded using the telephone monitor.HR during recurrences, and not statistically different between propafenone and placeboN/APropafenone efficacious in treating PSVT and PAF.Major limitation in not knowing how many pts had AVNRT. .Anderson1994 ADDIN REFMGR.CITE <Refman><Cite><Author>Anderson</Author><Year>1994</Year><RecNum>12</RecNum><IDText>Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>12</Ref_ID><Title_Primary>Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Anderson,J.L.</Authors_Primary><Authors_Primary>Platt,M.L.</Authors_Primary><Authors_Primary>Guarnieri,T.</Authors_Primary><Authors_Primary>Fox,T.L.</Authors_Primary><Authors_Primary>Maser,M.J.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Date_Primary>1994/9/15</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Confounding Factors (Epidemiology)</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time Factors</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>578</Start_Page><End_Page>584</End_Page><Periodical>Am J Cardiol</Periodical><Volume>74</Volume><Issue>6</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Department of Medicine, University of Utah, Salt Lake City</Address><Web_URL>PM:8074041</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(29)8074041 Long-term efficacy of flecainide (≥6 mo)49PSVT(n=21)PAF(n=28)PlaceboPts enrolled from 3 prior studies evaluating short-term flecainide efficacy Syncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) -Number of pts w/o attacks-Time to first attack-Interval between attacks-Average frequency of attacks,-Ventricular rate during attacks.PSVT pts:Of 17 efficacy evaluable pts, 14 (82%) had no SVT attacks during the chronic efficacy study compared w/ 4 (24%) w/ no attacks during placebo therapy at baseline (p=0.013).Time to first arrhythmia attack and time between attacks increasedduring chronic therapy w/ flecainide compared w/ placebo treatment (p=0.008 and p=0.012, respectively)Rates of attack/d not significantly different (p=0.130)No PSVT pts w/ ventricular arrhythmiasNo pt experiencedproarrhythmia, MI, or died during chronic efficacy study.N/AN/ASupports flecainide for chronic therapy of PSVT.Small numbers of pts w/ PSVT, and PSVT not specifically defined.Chimienti1995 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN EN.CITE.DATA (30)8682031Compare the long-term safety of flecainide and propafenone335SVT:flecainide 100 mg (n = 72) PAF:flecainide 200 mg (n = 97) SVT:propafenone 450 mg (n=63)PAF: propafenone 450 mg (n=103).SVT(n=135)PAF(n=200)LVEF <35%, AV block, QRS >140 msec, SSS, persistent AF (episodes >72 h), VT (episodes >30 sec), NYHA III-IV, ischemic heart disease, hypertrophic cardiomyopathy, hypotension, valvular disease, renal/hepatic insufficiency, thyroid disease, AADsITT analysis (probability of 12 mo safe and effective tx)PSVT:93% for flecainide and 86% for propafenone (p=0.24)PAF:77% for flecainide and 75% for propafenone (p=0.72)12 pts on flecainide reported 16 cardiac AEs, of whom 6 discontinued the treatment. 7 propafenone pts had 8 cardiac AEs, of whom 5 discontinued the treatment.(1 case of VT on propafenone2 cases of AF w/ rapid ventricular response on flecainideN/AN/ABoth flecainide and propafenone were safe in the long-term treatment of pts w/ PSVT.Only one-third of pts had SVT. UK Propafenone PSVT Study Group1995 ADDIN REFMGR.CITE <Refman><Cite><Year>1995</Year><RecNum>14</RecNum><IDText>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>14</Ref_ID><Title_Primary>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</Title_Primary><Date_Primary>1995/11/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>2550</Start_Page><End_Page>2557</End_Page><Periodical>Circulation</Periodical><Volume>92</Volume><Issue>9</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:7586356</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(31) 7586356Efficacy and tolerability of propafenone at 600 mg and 900 mg daily doses (given bid).2 consecutive crossover periods100Propafenone 300 mg bidPropafenone 300 mg tidPlaceboPSVT(n=52) PAF(n=48) 75 pts in low-dose phase:45 PSVT, 30 PAF59 pts advanced to high-dose phase:34 PSVT, 25 PAF ≥2 symptomatic episodes by transtelephonic monitoring PSVT w/ hemodynamic collapse, LVEF ≤25%, recent MI or unstable angina; hepatic/renal failure, SSS, AV block, AADs, female pts of childbearing potential, COPD, myasthenia gravis.Placebo vs. propafenone:PSVT, low-dose:Arrhythmia recurrence or AERR: 6.8 (95% CI: 2.2-21.2; p<0.001), Arrhythmia recurrenceRR: 7.4 (95% CI: 2.3-23.3, p<0.001).PSVT, high-dose:Arrhythmia recurrence or AERR: 2.2 (95% CI: 0.9-5.3, p=NS);Arrhythmia recurrenceRR: 15.0 (95: CI: 2.0-113, p=0.009). More pts experienced more AEs during propafenone (900 mg >600 mg). Most common adverse events during PSVT and PAF groups were related to the gastrointestinal and neuropsychiatric systems. Total numbers of adverse events on propafenone were 46 and 56 in the low-dose and high-dose PSVT group and 67 and 74 in the low-dose and high-dose PAF groups, respectively.1 episode of wide-complex tachycardia was documented during propafenone therapyPropafenone at 600 mg is effective and well tolerated. A larger dose of 900 mg causes more AEs but may be more effective in those who can tolerate itSequential design (not randomized after low-dose phase) so population is not generalizable at 900 mg dose. Not powered for mortality.Limited in that PSVTs included AVNRT, AT, or AVRT.Dorian1996 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvcmlhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvcmlhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl
Y051bT4xNzwvUmVjTnVtPjxJRFRleHQ+QSByYW5kb21pemVkIGNvbXBhcmlzb24gb2YgZmxlY2Fp
bmlkZSB2ZXJzdXMgdmVyYXBhbWlsIGluIHBhcm94eXNtYWwgc3VwcmF2ZW50cmljdWxhciB0YWNo
eWNhcmRpYS4gVGhlIEZsZWNhaW5pZGUgTXVsdGljZW50ZXIgSW52ZXN0aWdhdG9ycyBHcm91cDwv
SURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlw
ZT48UmVmX0lEPjE3PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+QSByYW5kb21pemVkIGNvbXBhcmlz
b24gb2YgZmxlY2FpbmlkZSB2ZXJzdXMgdmVyYXBhbWlsIGluIHBhcm94eXNtYWwgc3VwcmF2ZW50
cmljdWxhciB0YWNoeWNhcmRpYS4gVGhlIEZsZWNhaW5pZGUgTXVsdGljZW50ZXIgSW52ZXN0aWdh
dG9ycyBHcm91cDwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkRvcmlhbixQLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TmFjY2FyZWxsaSxHLlYuPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Db3VtZWwsUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5PkhvaG5sb3NlcixTLkguPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5NYXNlcixNLkouPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk2LzEvMjU8L0Rh
dGVfUHJpbWFyeT48S2V5d29yZHM+YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9LZXl3b3Jk
cz48S2V5d29yZHM+QWRtaW5pc3RyYXRpb24sT3JhbDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0
PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFudGktQXJyaHl0aG1pYSBBZ2VudHM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5BdHJpYWwgRmlicmlsbGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+ZHJ1ZyB0
aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb2NhcmRpb2dyYXBoeTwvS2V5d29yZHM+
PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZsZWNhaW5pZGU8L0tleXdvcmRz
PjxLZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5MaWZlIFRhYmxlczwvS2V5d29y
ZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29y
ZHM+PEtleXdvcmRzPlJlY3VycmVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwv
S2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFBhcm94eXNtYWw8L0tleXdvcmRzPjxLZXl3
b3Jkcz5UYWNoeWNhcmRpYSxTdXByYXZlbnRyaWN1bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhl
cmFwZXV0aWMgdXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdv
cmRzPlZlcmFwYW1pbDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0
YXJ0X1BhZ2U+ODlBPC9TdGFydF9QYWdlPjxFbmRfUGFnZT45NUE8L0VuZF9QYWdlPjxQZXJpb2Rp
Y2FsPkFtIEogQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjc3PC9Wb2x1bWU+PElzc3VlPjM8
L0lzc3VlPjxJU1NOX0lTQk4+MDAwMi05MTQ5PC9JU1NOX0lTQk4+PE1pc2NfMz5TMDAwMjkxNDk5
Nzg5MTIzMDwvTWlzY18zPjxBZGRyZXNzPlN0LiBNaWNoYWVsJmFwb3M7cyBIb3NwaXRhbCwgVW5p
dmVyc2l0eSBvZiBUb3JvbnRvLCBPbnRhcmlvLCBDYW5hZGE8L0FkZHJlc3M+PFdlYl9VUkw+UE06
ODYwNzM5NzwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5UaGUgQW1l
cmljYW4gam91cm5hbCBvZiBjYXJkaW9sb2d5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJu
YWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5BbSBKIENhcmRpb2w8L2Y+PC9aWl9Kb3VybmFs
U3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwv
UmVmbWFuPgB=
ADDIN EN.CITE.DATA (32)8607397Compare oral flecainide to verapamil in preventing PSVT recurrence121 pts at 32 sitesFlecainide (n=63) (50 mg bid increased to max of 300 mg/d)AVNRT(n=17)AVRT(n=6)Unspecified (n=40)Verapamil (n=58) (80 mg tid increased to max of 480 mg/d)AVNRT(n=10)AVRT(n=7)Unspecified (n=41)PSVT, requiring therapy, majority w/ ≥2 attacks per moAVNRTAVRTUnspecified PSVT but w/ clinical diagnosis of PSVTCoexisting PAF, prior MI/UA, NYHA Class III-IV, AV block, preexcitation, AADs86% of all flecainide 73% of all verapamil pt-mo occurred w/ 0-1 attack19 (30%) pts on flecainide vs. 7 (13% of verapamil completed the trial (>270 d) w/o symptomatic attacks (p= 0.026)f/u 8.1 ±5.1 mo for flecainide and 7.5± 5.4 mo w/ verapamil19% of flecainide group vs. 24% verapamil discontinued due to adverse effects (p=NS).Most common sx: flecainide: dizziness, concentration, sleep, nauseaVerapamil: dyspnea, fatigue, HF sxN/AThese agents confer potential benefit in pts who are not candidates for RFAN/AWanless1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbmxlc3M8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbmxlc3M8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (33)9124166Sotalol in treatment of PSVT126 Sotalol 80 mg(n=35)AVNRT (23%)Sotalol 160 mg(n=46)AVNRT (22%)Placebo(n=45)AVNRT (24%)Recurrent symptomatic PSVT were eligible for enrollment. AVNRTPAFParoxysmal atrial flutterAVRTParoxysmal AT Decompensated CHF, asthma, chronic obstructive airways disease, second degree or third degree AV block, recent MI (<1 mo), recent coronary artery bypass graft surgery (<2 mo), unstable angina pectoris, bradycardia (<50 bpm), SSS, prolonged QTc interval (>0.45 sec), systemic hypertension (diastolic BP >115 mm Hg), electrolyte imbalance, AADsTime to recurrence of PSVT was less compared w/ placebo when receiving sotalol 80 mg (p=0.04) and sotalol 160 mg (p=0.0009). On subanalysis, sotalol was shown to be effective in the prophylaxis of both PAF (p=0.03) and paroxysmal reentrant arrhythmias (p=0.0003).No deaths, cases of ventricular proarrhythmia, CHF. Treatment of pts receiving sotalol were discontinued because of typical beta blocker side effects, including bradycardia, dyspnea, and fatigue.N/AN/ASotalol efficacious in the prophylaxis of PSVT. Study limited due to grouping of PSVTs.Lim1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Lim</Author><Year>1998</Year><RecNum>3</RecNum><IDText>Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>3</Ref_ID><Title_Primary>Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage</Title_Primary><Authors_Primary>Lim,S.H.</Authors_Primary><Authors_Primary>Anantharaman,V.</Authors_Primary><Authors_Primary>Teo,W.S.</Authors_Primary><Authors_Primary>Goh,P.P.</Authors_Primary><Authors_Primary>Tan,A.T.</Authors_Primary><Date_Primary>1998/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Carotid Sinus</Keywords><Keywords>Electric Countershock</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Emergency Treatment</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Massage</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>30</Start_Page><End_Page>35</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>31</Volume><Issue>1</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196064498000146</Misc_3><Address>Department of Emergency Medicine, Singapore General Hospital, Singapore</Address><Web_URL>PM:9437338</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(34)9437338Efficacy of VM or CSM to terminate SVT in the EDN=148 Randomized to VM first (62) or CSM first (86), then crossed-over to other therapy if first not effectiveVM (blow into mouthpiece to achieve 40 mm Hg and sustain for at least 30 sec)CSM (randomized first to left or then right CSM)?10 y of age or olderECG w/ obvious atrial flutter, AF or sinus tachycardia, hemodynamically unstable (including poor cerebral perfusion, pulmonary edema or unstable angina). Pts w/ contraindications for CSM (h/o TIA, CVA, carotid bruit)Conversion to SRNo adverse events directly related to VM or CSM. One pt was diagnosed w/ non-Q wave MI. 4 pts admitted for other medical problems (HF, pneumonia)N/A62 VM first, 19.4% conversion;86 CSMc first, 10.5% conversionCrossover: to CSM, 14.0% conversion, and to VM w/ 16.9% conversionTotal conversion rate (VM and CSM, including cross-overs): 27.7%No difference in efficacy between VM and CSMVM more effective in men, CSM more effective in older ptsRecurrences w/in 2 h; 3 VM pts, 1 CSM ptN/AGupta A1999 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1cHRhPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1cHRhPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (35)10778689Efficacy of IV diltiazem vs. esmolol for terminating PSVTN=32 (study terminated prematurely due to superiority of diltiazem)Prospective randomized crossover, open-labeledEsmolol 0.5 mg/kg twice in 5 min intervalDiltiazem 0.25 mg/kg twice in 5 min intervalSVTHemodynamically tolerated in ICUSHD; AT, AF or atrial flutter excludedConversion to SRN/AN/ADiltiazem terminated SVT in all 16 pts where was first drugEsmolol terminated 4/16 (p<0.001 c/w diltiazem) and other 12 then terminated by diltiazem (total for diltiazem 28/28)Of the 28 pts responding to diltiazem a second dose was needed in 13.All 32 pts subsequently underwent EP study; 17 w/ AVNRT, 15 w/ AVRT. Diltiazem: first bolus converted 5/9 pts w/ AVNRT, and 0/7 w/ AVRT (p<0.0001)Esmolol: equally ineffective for either tachycardia mechanismSmall trial, terminated early due to superiority of diltiazem.Alboni2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsYm9uaTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJl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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsYm9uaTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (36)11216977Effectiveness of self-administered flecianide or diltiazem/propranolol to terminate SVTRandomized to placebo, flecainide (3 mg/kg), 120 mg diltiazem/80 mg propranolol on 3 different d for each ptN=33 (37 enrolled)Flecainide (3 mg/kg) or 120 mg diltiazem w/ 80 mg propranololPlaceboHemodynamically tolerated and long-lasting SVT confirmed by EP study to be reentrant (AVNRT or AVRT)Age 18-75, ≤5 episodes/yPreexcitation, CAD, sinus <50 bpm, LVEF <50% or HF, recent MI, or stroke, need for long term beta blocker, calcium channel blocker, digoxin or AAD or h/o sustained atrial or VTConversion w/in 2 h: 52% placebo, 61% flecainide, 94% diltiazem/propranolol (p<0.001). Conversion faster w/ diltiazem/propranolol (p<0.001)Hypotension, bradycardiaOver 17±12 mo treatment success f/u (SVT terminated in <2 h) in 81% of 26 diltiazem/propanolol pts, 80% of 5 flecainide pts% pts going to ED was 9% down from 100% of prior y (p<0.0001)Adverse events: hypotension in 1 placebo, 2 flecainide and 1 diltiazem/propranolol pts; 3 had sinus <50 bpm (3 diltiazem/propranolol, 1 flecainide)1 diltiazem/propranolol pt had syncope5 pts ultimately referred for ablationUnknown if outpt events that pts self-treated were indeed SVT and time to conversion assessed subjectively by ptOutpt management was not w/ placeboTendera2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlbmRlcmE8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlbmRlcmE8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS
ZWNOdW0+MTY8L1JlY051bT48SURUZXh0PkVmZmljYWN5IGFuZCBzYWZldHkgb2YgZG9mZXRpbGlk
ZSBpbiB0aGUgcHJldmVudGlvbiBvZiBzeW1wdG9tYXRpYyBlcGlzb2RlcyBvZiBwYXJveHlzbWFs
IHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWE6IGEgNi1tb250aCBkb3VibGUtYmxpbmQgY29t
cGFyaXNvbiB3aXRoIHByb3BhZmVub25lIGFuZCBwbGFjZWJvPC9JRFRleHQ+PE1ETCBSZWZfVHlw
ZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+MTY8L1JlZl9J
RD48VGl0bGVfUHJpbWFyeT5FZmZpY2FjeSBhbmQgc2FmZXR5IG9mIGRvZmV0aWxpZGUgaW4gdGhl
IHByZXZlbnRpb24gb2Ygc3ltcHRvbWF0aWMgZXBpc29kZXMgb2YgcGFyb3h5c21hbCBzdXByYXZl
bnRyaWN1bGFyIHRhY2h5Y2FyZGlhOiBhIDYtbW9udGggZG91YmxlLWJsaW5kIGNvbXBhcmlzb24g
d2l0aCBwcm9wYWZlbm9uZSBhbmQgcGxhY2VibzwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlRlbmRlcmEsTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PldudWstV29q
bmFyLEEuTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkt1bGFrb3dza2ksUC48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pk1hbG9sZXBzenksSi48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pktvemxvd3NraSxKLlcuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5LcnplbWluc2thLVBha3VsYSxNLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+U3plY2hpbnNraSxKLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+RHJvc3pjeixXLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+S2F3ZWNr
YS1KYXN6Y3osSy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN3aWF0ZWNrYSxH
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+UnV6eWxsbyxXLjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+R3JhZmYsTy48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9Q
cmltYXJ5PjIwMDEvNzwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZG1pbmlzdHJhdGlvbixPcmFs
PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFudGktQXJyaHl0aG1pYSBBZ2VudHM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5Eb3VibGUtQmxpbmQgTWV0aG9kPC9LZXl3b3Jkcz48S2V5d29yZHM+ZHJ1ZyB0
aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVt
YW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPlBoZW5l
dGh5bGFtaW5lczwvS2V5d29yZHM+PEtleXdvcmRzPnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwv
S2V5d29yZHM+PEtleXdvcmRzPlByb3BhZmVub25lPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvcG9y
dGlvbmFsIEhhemFyZHMgTW9kZWxzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJyZW5jZTwvS2V5
d29yZHM+PEtleXdvcmRzPlN1bGZvbmFtaWRlczwvS2V5d29yZHM+PEtleXdvcmRzPlN1cnZpdmFs
IEFuYWx5c2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3
b3Jkcz5UYWNoeWNhcmRpYSxTdXByYXZlbnRyaWN1bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhl
cmFwZXV0aWMgdXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdv
cmRzPlRyZWF0bWVudCBPdXRjb21lPC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVw
cmludD48U3RhcnRfUGFnZT45MzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+OTg8L0VuZF9QYWdlPjxQ
ZXJpb2RpY2FsPkFtIEhlYXJ0IEo8L1BlcmlvZGljYWw+PFZvbHVtZT4xNDI8L1ZvbHVtZT48SXNz
dWU+MTwvSXNzdWU+PElTU05fSVNCTj4wMDAyLTg3MDM8L0lTU05fSVNCTj48TWlzY18zPlMwMDAy
LTg3MDMoMDEpOTk4MzctMDsxMC4xMDY3L21oai4yMDAxLjExNTQzOTwvTWlzY18zPjxBZGRyZXNz
PjNyZCBEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFNpbGVzaWFuIE1lZGljYWwgQWNhZGVteSwg
S2F0b3dpY2UsIFBvbGFuZC4gbXRlbmRlcmFAa2F0b3dpY2UuY29tcHV0ZXJsYW5kLnBsPC9BZGRy
ZXNzPjxXZWJfVVJMPlBNOjExNDMxNjYzPC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1l
PSJTeXN0ZW0iPkFtZXJpY2FuIGhlYXJ0IGpvdXJuYWw8L2Y+PC9aWl9Kb3VybmFsRnVsbD48Wlpf
Sm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkFtIEhlYXJ0IEo8L2Y+PC9aWl9Kb3Vy
bmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRl
PjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (37) 11431663Comparison of dofetilide to propafenone and placebo in the prevention of PSVT122Dofetilide (n=40)Propafenone (n=41)Placebo (n=41)18-75 y w/ ≥1 episode of PSVT w/in 6 wk documented by ECGPulmonary disease, myasthenia gravis, bundle branch block, resting bradycardia (<50 bpm), AV block, prolonged QTc, MI, unstable angina, recent sudden death, hematologic /hepatic/renal diseaseAfter 6 mo of treatment, pts taking dofetilide, propafenone, and placebo had a 50%, 54%, and 6% probability, respectively, of remaining free of episodes of PSVT (p<0.001 for both dofetilide and propafenone vs. placebo).The hazard ratio for dofetilide vs. placebo was 0.33 (95% CI: 0.18-0.61), and the hazard ratio for propafenone vs. placebo was 0.27 (95% CI: 0.14-0.51).Of 40 pts treated w/ dofetilide and propafenone, 23 (58%) and 25 (61%) had no recurring PSVT, compared w/ 16 (39%) in placebo group.19 of 40 pts (48%) treated w/ dofetilide and 21 of 41 (51%) treated w/ propafenone reported no AEs. No significant differences were noted between 3 groups in incidence of treatment-related adverse events or all-cause adverse events (p=0.73 and p=0.74, respectively).Total number of episodes occurring during treatment, and type and frequency of sxs during episodes of PSVT before and during treatmentFrequency of episodes lower in pts treated w/ dofetilide or propafenone thancompared to placebo. Active treatment did not alter distribution of sxs during a first episode of PSVT.N/ADofetilide is at least as safe and effective as propafenone as an alternative therapeutic option for the treatment of pts w/ PSVT.Limited in that PSVTs not specified.Lim2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051
bT4yPC9SZWNOdW0+PElEVGV4dD5TbG93IGluZnVzaW9uIG9mIGNhbGNpdW0gY2hhbm5lbCBibG9j
a2VycyBjb21wYXJlZCB3aXRoIGludHJhdmVub3VzIGFkZW5vc2luZSBpbiB0aGUgZW1lcmdlbmN5
IHRyZWF0bWVudCBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhPC9JRFRleHQ+PE1ETCBS
ZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+Mjwv
UmVmX0lEPjxUaXRsZV9QcmltYXJ5PlNsb3cgaW5mdXNpb24gb2YgY2FsY2l1bSBjaGFubmVsIGJs
b2NrZXJzIGNvbXBhcmVkIHdpdGggaW50cmF2ZW5vdXMgYWRlbm9zaW5lIGluIHRoZSBlbWVyZ2Vu
Y3kgdHJlYXRtZW50IG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWE8L1RpdGxlX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5MaW0sUy5ILjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+QW5hbnRoYXJhbWFuLFYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5U
ZW8sVy5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hhbixZLkguPC9BdXRo
b3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA5LzU8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+
QWRlbm9zaW5lPC9LZXl3b3Jkcz48S2V5d29yZHM+YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl
PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5
dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+Qmxvb2QgUHJlc3N1cmU8L0tleXdvcmRz
PjxLZXl3b3Jkcz5DYWxjaXVtIENoYW5uZWwgQmxvY2tlcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5E
aWx0aWF6ZW08L0tleXdvcmRzPjxLZXl3b3Jkcz5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCxE
cnVnPC9LZXl3b3Jkcz48S2V5d29yZHM+RHJ1ZyBBZG1pbmlzdHJhdGlvbiBTY2hlZHVsZTwvS2V5
d29yZHM+PEtleXdvcmRzPmRydWcgZWZmZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhl
cmFweTwvS2V5d29yZHM+PEtleXdvcmRzPkVtZXJnZW5jeSBNZWRpY2FsIFNlcnZpY2VzPC9LZXl3
b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5
d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZnVzaW9ucyxJbnRy
YXZlbm91czwvS2V5d29yZHM+PEtleXdvcmRzPkluamVjdGlvbnMsSW50cmF2ZW5vdXM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+
PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1
ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFN1cHJhdmVudHJpY3VsYXI8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPlZl
cmFwYW1pbDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1Bh
Z2U+NTIzPC9TdGFydF9QYWdlPjxFbmRfUGFnZT41Mjg8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPlJl
c3VzY2l0YXRpb248L1BlcmlvZGljYWw+PFZvbHVtZT44MDwvVm9sdW1lPjxJc3N1ZT41PC9Jc3N1
ZT48SVNTTl9JU0JOPjAzMDAtOTU3MjwvSVNTTl9JU0JOPjxNaXNjXzM+UzAzMDAtOTU3MigwOSkw
MDA1Ny00OzEwLjEwMTYvai5yZXN1c2NpdGF0aW9uLjIwMDkuMDEuMDE3PC9NaXNjXzM+PEFkZHJl
c3M+RGVwYXJ0bWVudCBvZiBFbWVyZ2VuY3kgTWVkaWNpbmUsIFNpbmdhcG9yZSBHZW5lcmFsIEhv
c3BpdGFsLCBPdXRyYW0gUm9hZCwgU2luZ2Fwb3JlIDE2OTYwOCwgU2luZ2Fwb3JlPC9BZGRyZXNz
PjxXZWJfVVJMPlBNOjE5MjYxMzY3PC9XZWJfVVJMPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5h
bWU9IlN5c3RlbSI+UmVzdXNjaXRhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dv
cmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (38)19261367Efficacy and safety of slow infusion of calcium channel blockade vs. adenosine in the ED (RCT)?N=206Slow infusion of calcium channel blocker: verapamil 1 mg/min to 20 mg total, or diltiazem 2.5 mg/min to 50 mg totalIf failed calcium channel blocker then given adenosineAdenosine (6 mg followed by 12 mg if 6 mg ineffective) vs.(If adenosine ineffective after 12 mg they received a calcium channel blocker infusion)10 y of age or older, SVT not converted by vagal maneuverImpaired cerebral perfusion, subsequent diagnosis of non-SVT rhythm, pregnancyConversion to SRHypotensionOne pt that received calcium channel blocker became hypotensiveN/A102 pts received calcium channel blocker and 98% converted to SR, 104 pts got adenosine, conversion was 86.5% (p=0.002)BP dropped by -13.0/-8.1 verapamil and -7.0/-9.4 for diltiazem.Recurrences w/in 2 h: 1 pt w/ diltiazem, 2 from adenosine groupOne pt that received calcium channel blocker became hypotensiveSlow infusion of verapamil or diltiazem was effective and well tolerated. Fall in BP transient.Unclear how many pts were excluded from analysis as a non-SVT rhythm was then identified – how did this cohort fair?Smith2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Smith</Author><Year>2013</Year><RecNum>4</RecNum><IDText>Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>4</Ref_ID><Title_Primary>Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia</Title_Primary><Authors_Primary>Smith,G.D.</Authors_Primary><Authors_Primary>Dyson,K.</Authors_Primary><Authors_Primary>Taylor,D.</Authors_Primary><Authors_Primary>Morgans,A.</Authors_Primary><Authors_Primary>Cantwell,K.</Authors_Primary><Date_Primary>2013</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>physiology</Keywords><Keywords>Randomized Controlled Trials as Topic</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>CD009502</Start_Page><Periodical>Cochrane Database Syst.Rev.</Periodical><Volume>3</Volume><ISSN_ISBN>1469-493X</ISSN_ISBN><Misc_3>10.1002/14651858.CD009502.pub2</Misc_3><Address>Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia. gavin.smith@monash.edu</Address><Web_URL>PM:23543578</Web_URL><ZZ_JournalFull><f name="System">The Cochrane database of systematic reviews</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Cochrane Database Syst.Rev.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(39)23543578Determine effectiveness of VM to terminate SVTReview of 3 RCTs: 1) Mehta D 1988 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (40); 2) Wen ZC 1998 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051
bT4xNDY8L1JlY051bT48SURUZXh0PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5k
IGRldGVybWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94
eXNtYWwgc3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvSURUZXh0PjxNREwgUmVmX1R5cGU9
IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjE0NjwvUmVmX0lE
PjxUaXRsZV9QcmltYXJ5PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5kIGRldGVy
bWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94eXNtYWwg
c3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PldlbixaLkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuLFMuQS48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRhaSxDLlQuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5DaGlhbmcsQy5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+Q2hpb3UsQy5XLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hh
bmcsTS5TLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk5OC8xMi8xNTwvRGF0ZV9Q
cmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaW92ZW50cmljdWxh
ciBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+QXV0b25vbWljIFBhdGh3YXlzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QmFyb3JlZmxleDwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFs
ZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48
S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXNvcHJvdGVyZW5vbDwvS2V5d29y
ZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwvS2V5d29yZHM+
PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29y
ZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5c2lvbG9neTwvS2V5
d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlJlc2Vh
cmNoPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5U
YWNoeWNhcmRpYSxQYXJveHlzbWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3Vw
cmF2ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5WYWd1cyBOZXJ2ZTwvS2V5d29yZHM+PEtleXdvcmRzPlZhbHNhbHZhIE1hbmV1dmVyPC9L
ZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yNzE2PC9T
dGFydF9QYWdlPjxFbmRfUGFnZT4yNzIzPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5DaXJjdWxhdGlv
bjwvUGVyaW9kaWNhbD48Vm9sdW1lPjk4PC9Wb2x1bWU+PElzc3VlPjI0PC9Jc3N1ZT48SVNTTl9J
U0JOPjAwMDktNzMyMjwvSVNTTl9JU0JOPjxBZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb2xvZ3ks
IERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIE5hdGlvbmFsIFlhbmctTWluZyBVbml2ZXJzaXR5LCBT
Y2hvb2wgb2YgTWVkaWNpbmUsIGFuZCBWZXRlcmFucyBHZW5lcmFsIEhvc3BpdGFsLVRhaXBlaSwg
VGFpd2FuPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjk4NTE5NTg8L1dlYl9VUkw+PFpaX0pvdXJuYWxT
dGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5DaXJjdWxhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRB
YmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZt
YW4+
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051
bT4xNDY8L1JlY051bT48SURUZXh0PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5k
IGRldGVybWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94
eXNtYWwgc3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvSURUZXh0PjxNREwgUmVmX1R5cGU9
IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjE0NjwvUmVmX0lE
PjxUaXRsZV9QcmltYXJ5PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5kIGRldGVy
bWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94eXNtYWwg
c3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PldlbixaLkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuLFMuQS48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRhaSxDLlQuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5DaGlhbmcsQy5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+Q2hpb3UsQy5XLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hh
bmcsTS5TLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk5OC8xMi8xNTwvRGF0ZV9Q
cmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaW92ZW50cmljdWxh
ciBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+QXV0b25vbWljIFBhdGh3YXlzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QmFyb3JlZmxleDwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFs
ZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48
S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXNvcHJvdGVyZW5vbDwvS2V5d29y
ZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwvS2V5d29yZHM+
PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29y
ZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5c2lvbG9neTwvS2V5
d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlJlc2Vh
cmNoPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5U
YWNoeWNhcmRpYSxQYXJveHlzbWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3Vw
cmF2ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5WYWd1cyBOZXJ2ZTwvS2V5d29yZHM+PEtleXdvcmRzPlZhbHNhbHZhIE1hbmV1dmVyPC9L
ZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yNzE2PC9T
dGFydF9QYWdlPjxFbmRfUGFnZT4yNzIzPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5DaXJjdWxhdGlv
bjwvUGVyaW9kaWNhbD48Vm9sdW1lPjk4PC9Wb2x1bWU+PElzc3VlPjI0PC9Jc3N1ZT48SVNTTl9J
U0JOPjAwMDktNzMyMjwvSVNTTl9JU0JOPjxBZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb2xvZ3ks
IERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIE5hdGlvbmFsIFlhbmctTWluZyBVbml2ZXJzaXR5LCBT
Y2hvb2wgb2YgTWVkaWNpbmUsIGFuZCBWZXRlcmFucyBHZW5lcmFsIEhvc3BpdGFsLVRhaXBlaSwg
VGFpd2FuPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjk4NTE5NTg8L1dlYl9VUkw+PFpaX0pvdXJuYWxT
dGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5DaXJjdWxhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRB
YmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZt
YW4+
ADDIN EN.CITE.DATA (41); 3) Lim 1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Lim</Author><Year>1998</Year><RecNum>3</RecNum><IDText>Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>3</Ref_ID><Title_Primary>Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage</Title_Primary><Authors_Primary>Lim,S.H.</Authors_Primary><Authors_Primary>Anantharaman,V.</Authors_Primary><Authors_Primary>Teo,W.S.</Authors_Primary><Authors_Primary>Goh,P.P.</Authors_Primary><Authors_Primary>Tan,A.T.</Authors_Primary><Date_Primary>1998/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Carotid Sinus</Keywords><Keywords>Electric Countershock</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Emergency Treatment</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Massage</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>30</Start_Page><End_Page>35</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>31</Volume><Issue>1</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196064498000146</Misc_3><Address>Department of Emergency Medicine, Singapore General Hospital, Singapore</Address><Web_URL>PM:9437338</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(34).Mehta and Wen studies were in a lab setting, Lim in ED settingN/AN/AN/AN/AReversion to SRCardiovascular effects of VM (hypotension, bradycardia), mortality from VM, frequency and severity of adverse events from VMFailure to revert to SR followed by other therapies Reversion success was 54.3% (19/35) in Mehta, 45.9% (61/133) in Wen and 19.4% in Lim (12/62)Heterogeneity between studies precluded a meta analysis; adverse effects not reportedSpeculated that difference in conversion rates may be due to setting (ED vs. EP lab)AAD indicates antiarrhythmic drug; AE, adverse event; AF, atrial fibrillation; AP, accessory pathway; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; bid, two times per day; bpm, beats per minute; CAD, coronary artery disease; CHF, congestive heart failure; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CSM, carotid sinus massage; CVA, cerebral vascular accident; c/w, consistent with; ECG, electrocardiogram; ED, emergency department; EP, electrophysiological; f/u, follow up; HF, heart failure; h/o, history of; HR, heart rate; ICU, intensive care unit; ITT, insulin tolerance test; IV, intravenous; LVEF, left ventricular ejection fraction; MI, myocardial infarction; N/A, not applicable; NS, not significant; NSR, normal sinus rhythm; NYHA, New York Heart Association; PAF, paroxysmal atrial fibrillation; PSVT, paroxysmal supraventricular tachycardia; pt, patient; RCT, randomized controlled trial; RFA, radiofrequency ablation; RR, relative risk; SDC, serum drug concentration; SHD, structural heart disease; SR, sinus rhythm; SSS, sick sinus syndrome; SVT, supraventricular tachycardia; sx, symptom; TIA, transient ischemic attack; tid, three times per day; tx, treatment; UA, unstable angina; VHD, valvular heart disease; VM, Valsalva maneuver; VT, ventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 3. Nonrandomized Trials, Observational Studies, and/or Registries of Principles of Acute and Chronic Therapy – Section 2.4 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsWaxman1980 ADDIN REFMGR.CITE <Refman><Cite><Author>Waxman</Author><Year>1980</Year><RecNum>24</RecNum><IDText>Vagal techniques for termination of paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>24</Ref_ID><Title_Primary>Vagal techniques for termination of paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Waxman,M.B.</Authors_Primary><Authors_Primary>Wald,R.W.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Authors_Primary>Huerta,F.</Authors_Primary><Authors_Primary>Cameron,D.A.</Authors_Primary><Date_Primary>1980/10</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Bundle-Branch Block</Keywords><Keywords>Carotid Sinus</Keywords><Keywords>complications</Keywords><Keywords>drug therapy</Keywords><Keywords>Edrophonium</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Phenylephrine</Keywords><Keywords>physiopathology</Keywords><Keywords>Propranolol</Keywords><Keywords>Safety</Keywords><Keywords>Sympathetic Nervous System</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time Factors</Keywords><Keywords>Vagus Nerve</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>655</Start_Page><End_Page>664</End_Page><Periodical>Am J Cardiol</Periodical><Volume>46</Volume><Issue>4</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Web_URL>PM:7416025</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(42)7416025Prospective cohort consisting of 33 pts in ED (group A) and 35 pts during EP study (Group B) to assess SVT termination using a protocol of successive vagal interventions until SVT terminated: a) L/R CSP (1-5 sec) b) multiple unilateral CSP c) edrophonium IV followed by CSP d)Valsalva (10 sec) e) edrophonium IV followed by Valsalva f) phenylephrine N=68(33 Group A-ED, 38 Group B- EP study)SVT (AVNRT or AVRT (orthodromic). Overt WPW included.Termination to SRIn all 68 pts SVT was terminated. 6 pts required phenylephrine.No complications. Post termination pauses was 1683± 66 msIn group B (EP study) pts, repeated trials were performed w/ overall 92% success in termination.Data not broken down by group. However, text describes that 30/33 group A pts terminated SVT by a maneuver up to and including (e).Rankin AC1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Rankin</Author><Year>1989</Year><RecNum>25</RecNum><IDText>Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>25</Ref_ID><Title_Primary>Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias</Title_Primary><Authors_Primary>Rankin,A.C.</Authors_Primary><Authors_Primary>Oldroyd,K.G.</Authors_Primary><Authors_Primary>Chong,E.</Authors_Primary><Authors_Primary>Rae,A.P.</Authors_Primary><Authors_Primary>Cobbe,S.M.</Authors_Primary><Date_Primary>1989/9</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>diagnosis</Keywords><Keywords>diagnostic use</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>195</Start_Page><End_Page>203</End_Page><Periodical>Br.Heart J</Periodical><Volume>62</Volume><Issue>3</Issue><User_Def_5>PMC1216762</User_Def_5><ISSN_ISBN>0007-0769</ISSN_ISBN><Address>University Department of Medical Cardiology, Royal Infirmary, Glasgow</Address><Web_URL>PM:2789911</Web_URL><ZZ_JournalFull><f name="System">British heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Br.Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(43)2789911Cohort administered adenosine for either spontaneous tachycardia or inducedN=64 of which 54 pts had spontaneous tachycardia and 15 induced by programmed stimulationSpontaneous and induced tachycardia in 16-79 y old ptsTermination to SR and diagnostic efficacy to identify atrial flutter or AT or VTAdenosine terminated 46 of 48 episodes of narrow complex tachyOther tachycardias treated included wide complex (24 pts),Side effects: dysnea, chest pain, flushing, headache. No adverse hemodynamic effectsHigh rate of recurrence (1/3)Adenosine effective for both diagnosis and treatment. Of note administration in wide complex tachycardia was safe. Early recurrences of arrhythmias seen in 35%.Cairns1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Cairns</Author><Year>1991</Year><RecNum>22</RecNum><IDText>Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>22</Ref_ID><Title_Primary>Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Cairns,C.B.</Authors_Primary><Authors_Primary>Niemann,J.T.</Authors_Primary><Date_Primary>1991/7</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>complications</Keywords><Keywords>diagnosis</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electroencephalography</Keywords><Keywords>Emergencies</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>717</Start_Page><End_Page>721</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>20</Volume><Issue>7</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196-0644(05)80829-7</Misc_3><Address>UCLA School of Medicine, Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance 90509</Address><Web_URL>PM:2064090</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(44)2064090Observational cohortAdenosine to convert SR in ED settingN=2316 y or older presenting to ED in an 8 mo study period w/ sustained SVT, rate >140 bpmExclusion: severe CHF, unstable angina, acute MI by ECG, hemodynamic compromise. Excluded sinus tachycardia, atrial flutter, AF, QRS >140 msConversion to SR2 pts after adenosine identified as not having SVT (a fluter, VT)24 episodes of SVT in 21 pts of which 96% converted w/ adenosine (mean dose 10±6 mg)SVT recurred in 57% of episodes and other antiarrhythmic drugs then used to maintain SR. Adverse effects: 3 pts w/ chest pain, one pt w/ dyspnea but no adverse outcomeAdenosine highly effective in converted SVT but recurrences frequentMcCabe1992 ADDIN REFMGR.CITE <Refman><Cite><Author>McCabe</Author><Year>1992</Year><RecNum>21</RecNum><IDText>Intravenous adenosine in the prehospital treatment of paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>21</Ref_ID><Title_Primary>Intravenous adenosine in the prehospital treatment of paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>McCabe,J.L.</Authors_Primary><Authors_Primary>Adhar,G.C.</Authors_Primary><Authors_Primary>Menegazzi,J.J.</Authors_Primary><Authors_Primary>Paris,P.M.</Authors_Primary><Date_Primary>1992/4</Date_Primary><Keywords>Adenosine</Keywords><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Emergencies</Keywords><Keywords>Emergency Medical Services</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>358</Start_Page><End_Page>361</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>21</Volume><Issue>4</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196-0644(05)82650-2</Misc_3><Address>University of Pittsburgh Affiliated Residency in Emergency Medicine, Pennsylvania</Address><Web_URL>PM:1554170</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(45)1554170Prospective cohortAdenosine 6 mg , then 12 mg if ineffective, and 3rd dose of 12 mg if still ineffectiveN=37, prehospital setting18 y or older, w/ SVT assessed by paramedic, QRS <120 ms, rate 150-250 bpmExclusion: hypersensitivity to adenosine or in extremisConversion to SR26/37 in SVT (non-SVT rhythms were 5 AF, 4 sinus tach, 2 VT).23/26 (88%) converted to SR11 pts hypotensive at presentation in SVT and became stable upon conversion9 pts had WCT and no hemodynamic compromise w/ adenosineSmall prospective seriesGausche1994 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhdXNjaGU8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhdXNjaGU8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46)8037382Prospective cohortAdenosine 12 mg as initial dose, followed in 2 min of another 12 mg if no conversionN=129, 106 w/ before and after stripsPrehospital setting18 y or older, w/ SVT assessed by paramedic. QRS <120 msec, rate >140 bpm.Exclusion: pregnancy, hypersensitivity to adenosine, sbp <80 mm Hg, or on carbamazepine or dipyridamoleConversion to SR84/106 had SVT (AF in 13, ST in 5, atrial flutter in 2, and VT in 2 cases)71/84 converted to SR (85%) and 4 needed second 12 mg doseAdverse effects: chest pain (12), flushing (3), shortness of breath (2), nausea (1), anxiety (1), dizziness (1), headache (1)Adenosine safe and effective in prehospital setting.Madsen1995 ADDIN REFMGR.CITE <Refman><Cite><Author>Madsen</Author><Year>1995</Year><RecNum>19</RecNum><IDText>A comparison of adenosine and verapamil for the treatment of supraventricular tachycardia in the prehospital setting</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>19</Ref_ID><Title_Primary>A comparison of adenosine and verapamil for the treatment of supraventricular tachycardia in the prehospital setting</Title_Primary><Authors_Primary>Madsen,C.D.</Authors_Primary><Authors_Primary>Pointer,J.E.</Authors_Primary><Authors_Primary>Lynch,T.G.</Authors_Primary><Date_Primary>1995/5</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>diagnosis</Keywords><Keywords>Diagnostic Errors</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Emergency Medical Services</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medical Records</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>649</Start_Page><End_Page>655</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>25</Volume><Issue>5</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196-0644(95)70179-6</Misc_3><Address>City and County of San Francisco, Department of Public Health, Emergency Medical Services Agency, CA, USA</Address><Web_URL>PM:7741343</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(47)7741343Nonrandomized, prospective 12 mo chart review of adenosine w/ comparison to historical cohort that received verapamilPre-hospital setting (EMS)Verapamil up to 2 IV doses of 2.5 mg and 5 mg, or up to 2 doses of adenosine , 6 mg and 12 mgN=73Age >14 w/ paramedic assessment of narrow complex tachycardia (QRS <120, rate 160-240 bpm)3/1990-2/1991 (verapamil) and 3/1991-2/1992 (adenosine)Pts had to be regarded as stable and first underwent Valsalva prior to administration of verapamil or adenosine by base hospital physician’s orderConversion to SRAlso incidentally analyzed rate of ECG misinterpretation by EMS and base hospital physicianVerapamil given to 17 pts, of which 6 on subsequent review by cardiologist had AF, attach or sinus tach. 7/11 pts converted to SR (64%). Side effects in 5/17 pts (hypotension, NSVT, PACs)Adenosine: given to 64 pts, strips available for review in 56 pts. 24 pts on subsequent review by cardiologist had AF, attach, sinus tach, atrial flutter or VT. Of remaining 32 w/ true SVT that got adenosine, 78% converted to SR. Side effects: ventricular ectoic activity, 1st or 2nd degree AV block of <1 min, asystole (2-10 sec), chest pain, flushing, bronchospasm)Overall misinterpretation of the ECG occurred in 30/73 ptsNo difference in conversion rates between verapamil and adenosineMisinterpretation of the ECG by paramedics and base hospital physician was common.But serious adverse events unlikely – no reported hemodynamic collapse from intervention.Conversion to SR by adenosine or verapamil similar (about 70%)Brady1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyYWR5PC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyYWR5PC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (48)8727628Nonrandomized, prospective cohort w/ comparison to historical cohortComparison of adenosine (prospective cohort) to verapamil (historical cohort)N=211 Inclusion criteria: any age, narrow QRS tachycardia (120-300 bpm), or wide complex (120-300 bpm) who had received 2 doses of lidocaine, palpable pulse, IV in place.Exclusion: drug sensitivity, cardiac arrest, trauma etiology, for adenosine: prior cardiac transplant, treatment w/ carbamazepine or dipyridamoleExclusion for verapamil: sbp <90, pulmonary edema, LV dysfunction, age <2 y, WCTConversion to SRAdenosine: 87 of 105 pts received drug, 69% converted to SRVerapamil: 52 of 106 pts received drug, 88% converted to SR (p=0.1)Adverse events: adenosine: 4 pts (chest pain, dyspnea, prolonged brady, VT)Verapamil: 4 pts (hypotension, VT, VF) – 2 pts had received verapamil for WCT and both had hemodynamic collapseNoted that EMS commonly misinterpreted non-SVT rhythms as SVT (including AF, ST, VT)Adenosine and verapamil both effective in out of hospital setting to convert SVT. Rhythms were still commonly misidentified by EMSLuber2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Luber</Author><Year>2001</Year><RecNum>23</RecNum><IDText>Paroxysmal supraventricular tachycardia: outcome after ED care</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>23</Ref_ID><Title_Primary>Paroxysmal supraventricular tachycardia: outcome after ED care</Title_Primary><Authors_Primary>Luber,S.</Authors_Primary><Authors_Primary>Brady,W.J.</Authors_Primary><Authors_Primary>Joyce,T.</Authors_Primary><Authors_Primary>Perron,A.D.</Authors_Primary><Date_Primary>2001/1</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Aged</Keywords><Keywords>Calcium Channel Blockers</Keywords><Keywords>complications</Keywords><Keywords>Emergencies</Keywords><Keywords>Emergency Service,Hospital</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Recurrence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>40</Start_Page><End_Page>42</End_Page><Periodical>Am J Emerg.Med</Periodical><Volume>19</Volume><Issue>1</Issue><ISSN_ISBN>0735-6757</ISSN_ISBN><Misc_3>S0735-6757(01)87678-6;10.1053/ajem.2001.20030</Misc_3><Address>Department of Emergency Medicine, University of Virginia Health Sciences Center, Charlottesville-Albemarle Rescue Squad, Charlottesville, VA 22908, USA</Address><Web_URL>PM:11146016</Web_URL><ZZ_JournalFull><f name="System">The American journal of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(49)11146016Observational cohort (retrospective chart review)Outcomes of pts treated for SVT in ED, including recurrence rates, from 1993-1996N=111Narrow complex tachycardia (QRS <120 ms), no P waves, rate 120-300 bpm.1993-1996, single centerRecurrence of SVTDescriptive percentages of therapies given, pt demographicsTherapies given: adenosine (41%), Valsalva (22%), Calcium channel blocker (14%), beta blockers (4%), cardioversion (1%).79 pts (71%) discharged from ED, mean age of 49, mean ED stay of 3.8 h, and 3 pts had recurrent SVT w/in 24 h32 pts (29%) admitted to hospital, mean age 65, 6 pts (19%) had recurrent SVT in the hospital.SVT recurrence more likely in admitted pts (p<0.05), older pts (p<0.01) or h/o cardiac disease (p<0.01)Largely a descriptive paper. Roth A2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvdGg8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvdGg8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (50)12586276Prospective cohort study84PSVT 77%AF 23%Effectiveness of DC cardioversion in pts who did not respond promptly to vagal maneuvers that were tried first and then tried again after intravenously administered medical treatment w/ 1 of the following intravenously administered drugs: adenosine,verapamil, digoxin, and/or procainamide. All study pts were hemodynamically compromised but did not require cardiopulmonary resuscitation.DC cardioversion resulted in successful converson to sinus rhythm in all pts after 103 electrical attempts, using 118±69 Joules. No complications; all but 1 pt (w/ pulmonary edema and cardiogenic shock) discharged alive w/in 7 d of hospitalization. Use of DC cardioversion to restore sinus rhythm can be safely and efficaciously applied in the prehospital setting in pts who are hemodynamically compromised but do not require cardiopulmonary resuscitation.Chronic therapy of SVT (exclude WPW and preexcitation, but include if concealed AP)Neuss H1988 ADDIN REFMGR.CITE <Refman><Cite><Author>Neuss</Author><Year>1988</Year><RecNum>27</RecNum><IDText>Long-term efficacy and safety of flecainide for supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>27</Ref_ID><Title_Primary>Long-term efficacy and safety of flecainide for supraventricular tachycardia</Title_Primary><Authors_Primary>Neuss,H.</Authors_Primary><Authors_Primary>Schlepper,M.</Authors_Primary><Date_Primary>1988/8/25</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Clinical Trials as Topic</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Flecainide</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>56D</Start_Page><End_Page>61D</End_Page><Periodical>Am J Cardiol</Periodical><Volume>62</Volume><Issue>6</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>St. Vincenz Hospital, Limburg/Lahn, Federal Republic of Germany</Address><Web_URL>PM:3136637</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(51)3136637Open label trial of chronic po flecainide to pts that first given IV dose in EP lab. Pts w/ WPW (concealed or overt) or AVNRT.63 pts (47 WPW of which 8 concealed, 36 w/ AVNRT)Mean f/u 22.8 moWPW (overt or concealed) or AVNRT, previously refractory or intolerant to other antiarrhythmic drugs, verapamil or beta blockade)IV flecainide given during SVT induced at EP study (100 mg over 5 min)Drug efficacy and tolerance based upon diaryEP study also repeated while on therapyIn AVNRT pts (31) – mean observation of 23 mo, mean flecainide dose 257 mg/d, effective in 20 pts and reduced episodes in 4 other pts. Worsening of attacks seen in 2 pts.Adverse effects: visual, nervousness, dizziness, taste, hallucinations, vomiting. Therapy discontinued in 3 pts (AVNRT group)Flecainide effective in reducing subjective episodes – among pts w/ AVNRT was effective in 20/31 pts. Cockrell JL1991 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvY2tyZWxsPC9BdXRob3I+PFllYXI+MTk5MTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvY2tyZWxsPC9BdXRob3I+PFllYXI+MTk5MTwvWWVhcj48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ADDIN EN.CITE.DATA (52)1898629Open-label, uncontrolled trial of long term efficacy of flecainide63 pts.mean f/u 24 moAll pts w/ AV reentryDrug efficacy and toleranceFlecainide prevented or slowed AVRT in 44 pts. who were then followed and 33 (75%) w/ no adverse effects. Isuprel reversed the effects in 11/21 pts. Overall, 33 of 63 pts responded to and tolerated flecainide. 11 pts stopped due to adverse effects.Flecainide moderately helpful in about 50% of pts over 2 y.Jackman WM1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (53)1620170 Prospective observational cohort80Symptomatic AVNRT undergoing RFA of slow-pathwaySuccessful ablation w/ intact AV nodal conduction, guided by atrial slow-path potentialsRFA abolished or modified slow-pathway conduction in 78/80 pts w/o affecting normal AVN conduction. Mean (+/- SD) f/u of 15.5 mo w/o recurrence. Early report of success of RFA of slow-path conduction guided by atrial slow-path potentials—led to slow-pathway ablation being preferred method. Provided evidence that atrial insertions of fast and slow path are anatomically distinct.Gambhir DS1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbWJoaXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbWJoaXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (54)8682552 Prospective cohort study9All pts w/ symptomatic AVNRT, recurrent palpitations for 2-12 y EP study performed, IV amiodarone then oral therapy subsequently EP study repeated 1.5-3 mo laterNo pts reported sxs of tachycardia during mean f/u of 65 d on oral amiodaroneIV amiodarone terminated AVNRT in 7/9 pts (retrograde FP in 4/7 and anterograde SP in 3/7)Not inducible on PES after oral therapy, largely to due to prolonging refractoriness in atrium and ventricle, and depressing conduction through FPNo pts reported sxs of tachycardia during mean f/u of 65 d on oral amiodaroneIV amiodarone terminated AVNRT in 7/9 pts (retrograde FP in 4/7 and anterograde SP in 3/7)Not inducible on PES after oral therapy, largely to due to prolonging refractoriness in atrium and ventricle, and depressing conduction through FPSmall series of pts, but all w/ AVNRTOral therapy w/ amiodarone is effective in suppressing AVNRT.IV amiodarone is effective in acute therapy.EP study efficacy.Spector P2009 ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)19699343 Systematic review and meta-analysis to evaluate the safety and efficacy of RFA of AVNRT, AP-mediated, and atrial flutter.For AVNRT and AP-mediated: 39 primary studies w/ 49 treatment arms in 7,693 pts.Previous reviews or meta-analyses; animal or in vitro studies; subjects aged <18 y or mixed populations of which >15% were pediatric pts; f/u of <7 d; not studies of RFA; alternative energy sources used for ablation; AV junction ablation w/ pacemaker implantation; <40 pts per arrhythmia or ablation technique; published only in abstract form; published before 1990; and published in languages other than English, Spanish, French, Italian, German, and Portuguese.SVT (AVNRT and AP-mediated)Single- and multiple-procedure success, arrhythmia recurrence, repeat ablation, adverse events, and death Single-procedure success: 93.2% (95% CI 90.8-95.5%). Multiple-procedure success: 94.6%(95% CI 92.4- 96.9).Post-ablation arrhythmia: 5.6% (95% CI 4.1-7.2%). Repeat ablation: 6.5% (95% CI 4.7-8.3%)All-cause mortality: 0.1%Adverse events: 2.9% First meta-analysis of RFA for AVNRT, AVRT (AP-mediated). Demonstrates high efficacy rates and low rates of complications.Bohnen M2011PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvaG5lbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvaG5lbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN EN.CITE.DATA (56)21699857Prospective observational cohort, single centerIncidence and predictors for major complications of catheter ablation 1676 procedures All pts undergoing ablation in a 2 y period (2009-2011) at a high volume center for variety of arrhythmias (SVT, AF, VT due to SHD or idiopathic)Complications assessed over 30 d post-procedure.524 SVT ablations performed of which major complications (total 0.8%) included perforation (n=1), pseudoaneurysm (groin, n=2), pulmonary edema (1). No instances of conduction system damage Total major complication rate for SVT ablation below 1% in this contemporary prospective study.Outcomes (Registry Data)Hindricks G1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhpbmRyaWNrczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhpbmRyaWNrczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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=
ADDIN EN.CITE.DATA (57)8131762 Prospective cohort4398AT/atrial flutter (n=141, 3.2%)AVJ (n=900, 20.5%)AVNRT (n=815, 18.5%)AVRT: (n = 2222, 50.5%)VT (n=320, 7.3%).Incidence of complicationsComplications occurred in 223 pts (5.1%) overallAT/atrial flutter: 5.0%AVJ: 3.2%AVNRT: 8.0%AVRT: 4.4%VT: 7.5%Complications more in AVNRT RFA compared to AVJ or AP ablation (p<0.001) Complications more in VT compared to AVJ (p<0.002) or AP (p<0.02)Early report showing high incidence of complications after AVNRT ablation.Hindricks G1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Hindricks</Author><Year>1996</Year><RecNum>161</RecNum><IDText>Incidence of complete atrioventricular block following attempted radiofrequency catheter modification of the atrioventricular node in 880 patients. Results of the Multicenter European Radiofrequency Survey (MERFS) The Working Group on Arrhythmias of the European Society of Cardiology</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>161</Ref_ID><Title_Primary>Incidence of complete atrioventricular block following attempted radiofrequency catheter modification of the atrioventricular node in 880 patients. Results of the Multicenter European Radiofrequency Survey (MERFS) The Working Group on Arrhythmias of the European Society of Cardiology</Title_Primary><Authors_Primary>Hindricks,G.</Authors_Primary><Date_Primary>1996/1</Date_Primary><Keywords>adverse effects</Keywords><Keywords>analysis</Keywords><Keywords>Atrioventricular Block</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Cross-Sectional Studies</Keywords><Keywords>epidemiology</Keywords><Keywords>Europe</Keywords><Keywords>Heart Block</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Patients</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>82</Start_Page><End_Page>88</End_Page><Periodical>Eur Heart J</Periodical><Volume>17</Volume><Issue>1</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Web_URL>PM:8682135</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(58)8682135 Prospective cohort4463AVNRT (n=880)Incidence of AV blockAV block (4/ 880, 4.7%). AV block higher in fast pathway ablation (19/361, 5.3%, p<0.05) 6.3% in centers w/ limited experience in RFA (≤30 pts treated, p<0.05), and higher in these low-volume centers for both slow and fast pathway ablation (p<0.05)Early report showing 5% incidence of AV block after RFA for AVNRT, and higher w/ fast pathway ablation.Calkins H1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (59)9892593 Prospective cohort1050(previously enrolled in RFA clinical trial)RFA of AVNRT, AP, or AVJAVNRT (n=373)AP (n=500)AVJ (n=121)Efficacy and safety of RFA w/ long-term f/u.Overall success:95%Overall recurrence6%Success:AVNRT: 97%AP: 93%AVJ: 100%Recurrence:AVNRT: 5%AP: 8%AVJ: 2%Predictors of success:-AVNRTOR: 3.94 (95%CI: 1.93-8.04; p=0.0002)-Left free wall APOR: 3.09 (95% CI: 1.46-6.53; p=0.0003)-Experience of ablation center (>39 pts)OR: 2.39 (95% CI: 1.21- 4.71; p=0.012)Joint predictors of mortality:-EF (p=0.003)-SHD (p=0.016)-AVJ ablation (p=0.048)Shows RFA is a favorable option w/ low risk of complications and recurrence, and identifies pts who are at risk. Per-protocol analysisCheng2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (60)11103056Comparison of cost effectiveness of RFA w/ medical management of PSVTSymptomatic pts w/ 4.6 unscheduled visits/y for arrhythmia while on long-term drug therapyRFA:Estimated population:AVNRT: 65%AVRT w/ concealed AP: 30%Efficacy estimates:AVNRT: 97%AVRT w/ concealed AP: 93%Recurrence estimates:AVNRT: 5%AVRT w/ concealed AP: 8%Drug efficacy: 60%Perspective: societalOutcomes: costs (office visit, annual drug rx, EP study, RFA, PPM, PPM replacement)QALYLife-yearsMarginal cost-effectiveness ratiosW/ monthly episodes of PSVT, RFA most effective and least expensive optionRFA reduced lifetime medical expenditures by $27,940 compared w/ long-term pharmacologic therapyLifetime costs:RFA: $61,880Long-term drug rx:$89,820Episodic drug rx:$143,530RFA improved quality-adjusted life expectancy by 3.10 QALYs.RDA improves quality of life and reduces costs when treating highly symptomatic pts.Effects in less symptomatic not studiesScheinman MM2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Scheinman</Author><Year>2000</Year><RecNum>162</RecNum><IDText>The 1998 NASPE prospective catheter ablation registry</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>162</Ref_ID><Title_Primary>The 1998 NASPE prospective catheter ablation registry</Title_Primary><Authors_Primary>Scheinman,M.M.</Authors_Primary><Authors_Primary>Huang,S.</Authors_Primary><Date_Primary>2000/6</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Arteries</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiomyopathies</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Disease</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Hospitals,Teaching</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Recurrence</Keywords><Keywords>Registries</Keywords><Keywords>statistics & numerical data</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Ventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>1020</Start_Page><End_Page>1028</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>23</Volume><Issue>6</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>Department of Medicine, University of California, San Francisco, USA. scheinman@ep4.ucsf.edu</Address><Web_URL>PM:10879389</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(61)10879389 Prospective cohort study(NASPE registry)3,357Ablation of AVNRT, AP, AVJ, atrial flutter, AT, IST, VT, idiopathic VTAVNRT (n=1,197 [35.6%)AVJ (n=646)AP (n=654)AT (n=216)Atrial flutter (n=447)IST (n=40)Efficacy and safety of RFA w/ long-term f/u.AVNRTSuccess: 96.1%Complications: 2%AVJ: Success: 96%Complications: 25 ptsRecurrence:3.5%AP:Success: 94-96%Complications: 31 pts totalRecurrence: 4.6%AT:Success: 51-79%Complications:5 totalRecurrence:15.2%Atrial flutter:Success: 86%Complications:12 ptsRecurrence:14.7%IST:Success: 71%Complications:2 ptsRecurrence:10%Large series reporting success of RFA, and stratification by age group confirms safety and efficacy in elderly pts, as well as by type of facility (teaching vs. community).AF, atrial fibrillation; AT, atrial tachycardia; AP, accessory pathway; AV, atrioventricular; AVJ, atrioventricular junction; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; bpm, beats per minute; CHF, congestive heart failure; CI, confidence interval; CSP, carotid sinus pressure; DC, direct current; ECG, electrocardiogram; ED, emergency department; EF, ejection fraction; EMS, emergency medical services; EP, electrophysiological; FP, fast pathway; f/u, follow up; h/o, history of; IST, inappropriate sinus tachycardia; IV, intravenous; LV, left ventricular; MI, myocardial infarction; NASPE, North American Society of Pacing and Electrophysiology; NSVT, non-sustained ventricular tachycardia; OR, odds ratio; PAC, premature atrial complex; PES, programmed electrical stimulation; PPM, prosthesis-patient mismatch; PSVT, paroxysmal supraventricular tachycardia; pt, patient; QALY, quality-adjusted life year; RFA, radiofrequency ablation; rx, prescription; sbp, systolic blood pressure; SD, standard deviation; SHD, structural heart disease; SP, slow pathway; SR, sinus rhythm; ST, sinus tachycardia; SVT, supraventricular tachycardia; VF, ventricular fibrillation; VT, ventricular tachycardia; WCT, wide complex tachycardia; w/, with; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 4. Randomized Trials Comparing Sinus Tachyarrhythmias – Section 3 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsBEAUTIFUL2008 ADDIN REFMGR.CITE <Refman><Cite><Author>Fox</Author><Year>2008</Year><RecNum>50</RecNum><IDText>Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>50</Ref_ID><Title_Primary>Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial</Title_Primary><Authors_Primary>Fox,K.</Authors_Primary><Authors_Primary>Ford,I.</Authors_Primary><Authors_Primary>Steg,P.G.</Authors_Primary><Authors_Primary>Tendera,M.</Authors_Primary><Authors_Primary>Ferrari,R.</Authors_Primary><Date_Primary>2008/9/6</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Benzazepines</Keywords><Keywords>complications</Keywords><Keywords>Coronary Disease</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Hospital Mortality</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Kaplan-Meier Estimate</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>pharmacology</Keywords><Keywords>Safety</Keywords><Keywords>therapeutic use</Keywords><Keywords>Ventricular Dysfunction,Left</Keywords><Reprint>Not in File</Reprint><Start_Page>807</Start_Page><End_Page>816</End_Page><Periodical>Lancet</Periodical><Volume>372</Volume><Issue>9641</Issue><ISSN_ISBN>1474-547X</ISSN_ISBN><Misc_3>S0140-6736(08)61170-8;10.1016/S0140-6736(08)61170-8</Misc_3><Address>Royal Brompton Hospital, London, UK</Address><Web_URL>PM:18757088</Web_URL><ZZ_JournalStdAbbrev><f name="System">Lancet</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(62)18757088To determine if HR lowering w/ ivabradine reduces cardiovascular death and morbidity in pts w/ coronary disease and LV systolic dysfunctionRandomized, double blind placebo controlled, parallel group. Multicenter10,917 pts enrolled. Intention to treat analysisIvabradine 5 mg increased to 7.5 mg bidPlaceboCoronary artery disease, LVEF <40%Age ≥55, or ≥18 if diabeticSinus rhythm, HR≥60 bpmAngina and HF sxs stable over 3 mo prior to enrollment on stable doses of at least 1 mo of conventional medical therapy MI or coronary revascularization w/in prior 6 moStroke/TIA in prior 3 moPacemaker or ICDVHD needing surgery w/in 3 ySick sinus syndrome, long QT, complete heart block, uncontrolled HTN, NYHA IVOther medications w/ strong CYP P450 3A4 inhibitionComposite of cardiovascular death, hospital admission for acute MI, hospital admission for new onset or worsening HFN/AMortalityCardiac death (MI, HF, due to cardiac procedureCardiovascular deathHospital admit for acute MI or unstable anginaCoronary revascularizationHospital admit for HFHospital admit for acute MIMedian f/u 19 mo. Baseline mean HR 71.6±9.9 bpm, lowered at 12 mo by 6 bpm and by 5 bpm at 24 mo corrected for placeboPrimary endpoint unchanged by ivabradineFor pts w/ HR of 70 bpm or higher, ivabradine reduced admit to hospital for fatal and non fatal MI and coronary revascularization (secondary endpoints)87% were on beta blockersNo difference in serious adverse events between pts treated w/ ivabradine or placeboHeart rate reduction not a specified endpoint of the trial, though is reported.Not an IST population but trial does demonstrate safety of ivabradine in a high risk population in a large, randomized, placebo controlled trialHeart rate reduction modest but baseline heart rates are lower compared to an IST population.SHIFT2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN3ZWRiZXJnPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN3ZWRiZXJnPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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==
ADDIN EN.CITE.DATA (63)20801500To determine if HR lowering w/ ivabradine improves outcomes in HFRandomized, double-blind, placebo-controlled, parallel-group. Multicenter trial that enrolled 6558 pts.Ivabradine 5-7.5 mg bidPlaceboAge ≥18 in sinus w/ resting HR of ≥70Stable HF sxs over prior 4 wkPrior hospital admit for HF in previous 12 moLVEF ≤35%On optimum, stable medical therapy over prior 4 wkCHDPrimary severe valvular diseaseRecent MI (<2 mo)Pacing for ≥40%/dAF/atrial flutterSymptomatic hypotensionPts not allowed to receive non-dihydropyridine calcium channel blocker, class I anti-arrhythmic or strong inhibitor of CYP3A4Composite of cardiovascular death or hospital admission for worsening HF. Intention to treat analysisN/AComposite cardiovascular death or hospital admit for worsening HF in pts receiving at least 50% of target daily dose of beta blocker (metoprolol target dose = 150 mg/d)All cause deathAny CV deathHospital admit (any)CV hospital admitDeath from HFComposite of CV death, hospital admit for worsening HF, hospital admit for non-fatal MIMedian f/u 22.9 mo. HR at 28 d decreased by 15.4±10.7 bpm in ivabradine c/w baseline and by 10.9 (CI 10.4-11.4) bpm c/w placebo. At 1 y, HR reduction was 9.1 (CI 8.5-9.7) bpm c/w placebo, and at study end 8.1 (CI 7.5-8.7) bpm c/w placeboPrimary endpoint reached in 24% of ivabradine group and 29% of placebo (p<0.0001), driven by difference in hospital admission for HF and death due to HF. Fewer serious adverse events in ivabradine group (p=0.025). 5% of ibabradine pts w/ symptomatic bradycardia compared to 1% of placebo (p<0.0001). Visual side effects (phosphenes) in 3% of ivabradine group vs. 1% of placebo (p<0.0001)Heart rate reduction not a specified endpoint of the trial, though is reported.Not an IST population but trial does demonstrate safety of ivabradine in a high risk population in a large, randomized, placebo controlled trialHR reduction modest but baseline heart rates are lower compared to an IST population.Cappato R2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhcHBhdG88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhcHBhdG88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (64)22981555To determine the effectiveness of ivabradine to reduce sxs due to ISTDouble blind, randomized, placebo controlled crossover (N = 21) Ivabradine (2.5-7.5 mg twice daily) for 6 wk then 7 d washout then crossover to placebo for 6 wk (n = 10) Placebo for 6 wk then 7 d washout then crossover to ivabradine for 6 wk (n = 9)Mean resting dtime HR >95 on Holter or >25 bpm symptomatic rise in HR from supine to standing or in response to stressUnderlying SHD (excluded by echocardiogram), SVT, orthostatic hypotension, compensatory sinus tachycardia, on antiarrhythmic therapy, renal or hepatic insufficiency, on inhibitor of CYP3A4Sx resolution from 7 sx indicatorsN/AHR measurements (rest, exercise), exercise capacityIvabradine: >70% sx elimination (RR: 0.25; 95% CI: 0.18-0.34; p<0.001), resting heart rate reduced (p=0.011), and during exertion (p=0.001) and increased exercise performanceDuration of therapy short (6 wk), some pts did not improve in sxs despite heart rate reductions. Long term effectiveness and safety not studied.AF indicates atrial fibrillation; bid, two times per day; bpm indicates beats per min; CI, confidence interval; CPY3A4, cytochrome p450 3A4; CV, cardiovascular; c/w, consistent with; f/u, follow up; HF, heart failure; HR, heart rate; LV, left ventricular; LVEF, left ventricular ejection fraction; MI, myocardial infarction; IAST, inappropriate sinus tachycardia; N/A, not available; pt, patient; RR, relative risk; SHD, structural heart disease; sx, symptom; TIA, transient ischemic attack; and w/, with. Data Supplement 5. Nonrandomized Trials, Observational Studies, and/or Registries of Sinus Tachyarrhythmias – Section 3StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsLee RJ1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051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 EN.CITE.DATA (65)7586260Prospective observational16 pts (12 w/ SAN modification and 4 w/ SAN ablation)Symptomatic, medically refractory pts w/ IST undergoing RFA enrolledProcedure: - Activation mapping (point-by-point)- Mapping guided by fluoroscopy or ICE (to visualize crista)- IsoproterenolF/u tests:- Autonomic blockade (intrinsic HR) w/ propranolol + atropine before and after ablation - ETT- HolterProcedural success:SAN modification: at least 25% reduction in sinus HR under same conditions of catecholamine infusion w/ either retention of normal P wave axis or low atrial escapeTotal SAN ablation: reduction in HR >50% of tachycardia HR w/ junctional escapeMean f/u = 20.5±0.4 moSAN modification:- Procedural success 12/12 (100%) pts- 2 recurrences during F/U 7.1±1.7 moTotal SAN ablation:- Procedural success 4/4 (100%) pts- No recurrences at F/UComplications:- 2 pts PPM (both had total SAN ablation)- 1 pt transient right diaphragmatic paralysis- 1 pt transient SVC syndrome- SAN modification is feasible and should be considered as alternative to complete AV junction ablation in pts w/ disabling sxs of IST that is refractory to medical therapy. -SAN modification may be aided by ICE. Rakovec P2009 ADDIN REFMGR.CITE <Refman><Cite><Author>Rakovec</Author><Year>2009</Year><RecNum>60</RecNum><IDText>Treatment of inappropriate sinus tachycardia with ivabradine</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>60</Ref_ID><Title_Primary>Treatment of inappropriate sinus tachycardia with ivabradine</Title_Primary><Authors_Primary>Rakovec,P.</Authors_Primary><Date_Primary>2009</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Benzazepines</Keywords><Keywords>diagnosis</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Metoprolol</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Sinus</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>715</Start_Page><End_Page>718</End_Page><Periodical>Wien.Klin.Wochenschr.</Periodical><Volume>121</Volume><Issue>21-22</Issue><ISSN_ISBN>1613-7671</ISSN_ISBN><Misc_3>10.1007/s00508-009-1265-9</Misc_3><Address>Department of Cardiology, University Medical Center, Ljubljana, Slovenia. peter.rakovec@kclj.si</Address><Web_URL>PM:19998013</Web_URL><ZZ_JournalFull><f name="System">Wiener klinische Wochenschrift</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Wien.Klin.Wochenschr.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(66)19998013Consecutively treated cohort13Resting HR on ECG >100 bpmNormal thyroid function, SHD excluded by echocardiogramEvaluation at baseline (ECG, Holter) and after 2 wk on ivabradine 15 mg/d (repeat Holter)11 women, 2 men, mean age 42±8 y7/13 were pretreated w/ beta blockers.Mean HR decreased from 94±10 to 74.6±5.2 bpm w/ ivabradine (12 pts whose prior therapy could be discontinued or did not have prior therapy drug therapy). In 10 pts where min and max HR could be determined, the max HR decreased from 150.3±13.4 bpm to 120.6± 9.8 bpm and min HR decreased from 66.7±9.6 to 54.8±6.9.P<0.001 for all HR comparisons (paired t tests).One pt on metoprolol 300 mg/d switched to 15 mg of ivabradine and decrease of 4 bpm noted.Limitation – small cohort, no meaningful comparisons to beta blockade could be made.Calo L2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbG88L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbG88L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (67)20621618Prospective, nonrandomized consecutively enrolled cohort18Inclusion: Symptomatic IST,Exclusion: secondary causes of tachycardia, SHD (echocardiogram performed)Beta blockers and non-dihydropyridine calcium channel blockers interrupted before studyStress test ECG for evaluation of sxs, maximal load, basal HR, maximal HR. Evaluation of stress ECG and 24-h Holter made at baseline, 3 mo, 6 moPts treated w/ ivabradine 5 mg-7.5 mg twice dailyMean and maximal HR on Holter reduced compared to baseline at 3 or 6 mo (p<0.001) and at 6 mo compared to 3 mo (p=0.02)Resting and Maximal HR on stress test reduced and increased achieved maximal loadIvabradine lowers HR and improves sxs over 3 to 6 mo.Limitation – non-randomized, small cohortKaplinsky E2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthcGxpbnNreTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthcGxpbnNreTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+
PFJlY051bT41NjwvUmVjTnVtPjxJRFRleHQ+RWZmaWNhY3kgb2YgaXZhYnJhZGluZSBpbiBmb3Vy
IHBhdGllbnRzIHdpdGggaW5hcHByb3ByaWF0ZSBzaW51cyB0YWNoeWNhcmRpYTogYSB0aHJlZSBt
b250aC1sb25nIGV4cGVyaWVuY2UgYmFzZWQgb24gZWxlY3Ryb2NhcmRpb2dyYXBoaWMsIEhvbHRl
ciBtb25pdG9yaW5nLCBleGVyY2lzZSB0b2xlcmFuY2UgYW5kIHF1YWxpdHkgb2YgbGlmZSBhc3Nl
c3NtZW50czwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFs
PC9SZWZfVHlwZT48UmVmX0lEPjU2PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+RWZmaWNhY3kgb2Yg
aXZhYnJhZGluZSBpbiBmb3VyIHBhdGllbnRzIHdpdGggaW5hcHByb3ByaWF0ZSBzaW51cyB0YWNo
eWNhcmRpYTogYSB0aHJlZSBtb250aC1sb25nIGV4cGVyaWVuY2UgYmFzZWQgb24gZWxlY3Ryb2Nh
cmRpb2dyYXBoaWMsIEhvbHRlciBtb25pdG9yaW5nLCBleGVyY2lzZSB0b2xlcmFuY2UgYW5kIHF1
YWxpdHkgb2YgbGlmZSBhc3Nlc3NtZW50czwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PkthcGxpbnNreSxFLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q29tZXMsRi5Q
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VXJvbmRvLEwuUy48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkF5bWEsRi5QLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRl
X1ByaW1hcnk+MjAxMDwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtl
eXdvcmRzPkFudGktQXJyaHl0aG1pYSBBZ2VudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5CZW56YXpl
cGluZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5k
cnVnIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb2Nh
cmRpb2dyYXBoeSxBbWJ1bGF0b3J5PC9LZXl3b3Jkcz48S2V5d29yZHM+RXhlcmNpc2U8L0tleXdv
cmRzPjxLZXl3b3Jkcz5FeGVyY2lzZSBUb2xlcmFuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1h
bGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJh
dGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2Rz
PC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+
UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwvS2V5d29yZHM+PEtleXdvcmRzPlByb3NwZWN0aXZl
IFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5wc3ljaG9sb2d5PC9LZXl3b3Jkcz48S2V5d29y
ZHM+UXVhbGl0eSBvZiBMaWZlPC9LZXl3b3Jkcz48S2V5d29yZHM+UXVlc3Rpb25uYWlyZXM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5TcGFpbjwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9L
ZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU2ludXM8L0tleXdvcmRzPjxLZXl3b3Jkcz50
aGVyYXBldXRpYyB1c2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPlZlcmFwYW1p
bDwvS2V5d29yZHM+PEtleXdvcmRzPllvdW5nIEFkdWx0PC9LZXl3b3Jkcz48UmVwcmludD5Ob3Qg
aW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4xNjY8L1N0YXJ0X1BhZ2U+PEVuZF9QYWdlPjE3
MTwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+Q2FyZGlvbCBKPC9QZXJpb2RpY2FsPjxWb2x1bWU+MTc8
L1ZvbHVtZT48SXNzdWU+MjwvSXNzdWU+PElTU05fSVNCTj4xODk3LTU1OTM8L0lTU05fSVNCTj48
QWRkcmVzcz5DYXJkaW9sb2d5IFVuaXQsIEhvc3BpdGFsIE11bmljaXBhbCBkZSBCYWRhbG9uYSwg
QmFyY2Vsb25hLCBTcGFpbi4gZWthcGxpbnNreUBic2EuY2F0PC9BZGRyZXNzPjxXZWJfVVJMPlBN
OjIwNTQ0NjE2PC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPkNhcmRp
b2xvZ3kgam91cm5hbDwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2Pjxm
IG5hbWU9IlN5c3RlbSI+Q2FyZGlvbCBKPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29y
a2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN EN.CITE.DATA (68)20544616Prospective, observational cohort4Resting HR ≥100, mean HR ≥90 on 24-h HolterAlso noted: not previously treated w/ beta blocker or verapamil. SHD and secondary causes of tachycardia excludedEvaluation at baseline, wk 1, 2, 3 and 4 and 2nd and 3rd mo. At 3 mo, Holter, ETT and QOL questionnaire performed.Ivabradine initiated at 5 mg bid, increased to 7.5 mg bid after first wk.Ivabradine decreased resting HR from mean of 106.5±3 at baseline to 88.5 ±2 at wk 1 and 77 ±3 by wk 2 and 73.7 ±13 at mo 3. Holter monitor determined mean, max and minimum HR also reduced by 15-24% compared to baseline, exercise time increased, QOL improved. Limitation- small cohortZellerhoff S2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlplbGxlcmhvZmY8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlplbGxlcmhvZmY8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy
PjxSZWNOdW0+NjE8L1JlY051bT48SURUZXh0Pkl2YWJyYWRpbmUgaW4gcGF0aWVudHMgd2l0aCBp
bmFwcHJvcHJpYXRlIHNpbnVzIHRhY2h5Y2FyZGlhPC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91
cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+NjE8L1JlZl9JRD48VGl0
bGVfUHJpbWFyeT5JdmFicmFkaW5lIGluIHBhdGllbnRzIHdpdGggaW5hcHByb3ByaWF0ZSBzaW51
cyB0YWNoeWNhcmRpYTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlplbGxlcmhvZmYs
Uy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkhpbnRlcnNlZXIsTS48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkZlbGl4LEtydWxsIEIuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5TY2h1bHplLUJhaHIsRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0
aG9yc19QcmltYXJ5PkZhYnJpdHosTC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PkJyZWl0aGFyZHQsRy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PktpcmNoaG9m
LFAuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5LYWFiLFMuPC9BdXRob3JzX1By
aW1hcnk+PERhdGVfUHJpbWFyeT4yMDEwLzEyPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xl
c2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHJlbmVyZ2ljIGJldGEtQW50YWdvbmlzdHM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFudGktQXJyaHl0aG1p
YSBBZ2VudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5CZW56YXplcGluZXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5kcnVnIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8L0tleXdv
cmRzPjxLZXl3b3Jkcz5EcnVnIFRoZXJhcHksQ29tYmluYXRpb248L0tleXdvcmRzPjxLZXl3b3Jk
cz5FeGVyY2lzZTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRz
Pkdlcm1hbnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhl
YXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5N
aWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPk9mZi1MYWJlbCBVc2U8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5waGFybWFjb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRob2xvZ3k8
L0tleXdvcmRzPjxLZXl3b3Jkcz5TaW5vYXRyaWFsIE5vZGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5T
eW5jb3BlPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jk
cz5UYWNoeWNhcmRpYSxTaW51czwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwv
S2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxl
PC9SZXByaW50PjxTdGFydF9QYWdlPjQ4MzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+NDg2PC9FbmRf
UGFnZT48UGVyaW9kaWNhbD5OYXVueW4uU2NobWllZGViZXJncy5BcmNoLlBoYXJtYWNvbDwvUGVy
aW9kaWNhbD48Vm9sdW1lPjM4MjwvVm9sdW1lPjxJc3N1ZT41LTY8L0lzc3VlPjxJU1NOX0lTQk4+
MTQzMi0xOTEyPC9JU1NOX0lTQk4+PE1pc2NfMz4xMC4xMDA3L3MwMDIxMC0wMTAtMDU2NS15PC9N
aXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5IGFuZCBBbmdpb2xvZ3ksIEhv
c3BpdGFsIG9mIHRoZSBVbml2ZXJzaXR5IG9mIE11bnN0ZXIsIE11bnN0ZXIsIEdlcm1hbnk8L0Fk
ZHJlc3M+PFdlYl9VUkw+UE06MjA4NTk2MTY8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5h
bWU9IlN5c3RlbSI+TmF1bnluLVNjaG1pZWRlYmVyZyZhcG9zO3MgYXJjaGl2ZXMgb2YgcGhhcm1h
Y29sb2d5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0i
U3lzdGVtIj5OYXVueW4uU2NobWllZGViZXJncy5BcmNoLlBoYXJtYWNvbDwvZj48L1paX0pvdXJu
YWxTdGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+
PC9SZWZtYW4+AG==
ADDIN EN.CITE.DATA (69)20859616Prospective observational cohort10Pts had failed or refused conventional therapy (beta blocker, calcium channel blocker, class IC AAD). Blood count, electrolytes and TSH normal. SHD excluded.EP study performed in 3 pts to exclude SVT. One pt w/ prior ablation of sinus node and pacemaker and another pt w/ prior ablation.Ivabradine 5 mg-7.5 mg bid, w/ additional beta blocker therapy in 3 pts and monotherapy in 7 pts.72-h Holter at baseline and during therapy. Sx assessment performed by telephone at mean f/u of 16±9 moIvabradine reduced max and mean HR (baseline, max heart = 176±45, mean 84±11. On ivabradine max HR was 137 ±36 and mean 74±8 bpm, p<0.05. Min HR not significantly changedOf 8 pts contacted on followup at 16±9 mo, sxs improved in 3 pts and completely resolved in 5 pts.Limitation – small cohortBenezet-Mazuecos J2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Benezet-Mazuecos</Author><Year>2013</Year><RecNum>55</RecNum><IDText>Long-term outcomes of ivabradine in inappropriate sinus tachycardia patients: appropriate efficacy or inappropriate patients</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>55</Ref_ID><Title_Primary>Long-term outcomes of ivabradine in inappropriate sinus tachycardia patients: appropriate efficacy or inappropriate patients</Title_Primary><Authors_Primary>Benezet-Mazuecos,J.</Authors_Primary><Authors_Primary>Rubio,J.M.</Authors_Primary><Authors_Primary>Farre,J.</Authors_Primary><Authors_Primary>Quinones,M.A.</Authors_Primary><Authors_Primary>Sanchez-Borque,P.</Authors_Primary><Authors_Primary>Macia,E.</Authors_Primary><Date_Primary>2013/7</Date_Primary><Keywords>Adult</Keywords><Keywords>Benzazepines</Keywords><Keywords>Cardiotonic Agents</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Longitudinal Studies</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Patient Satisfaction</Keywords><Keywords>Quality of Life</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Sinus</Keywords><Keywords>therapeutic use</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>830</Start_Page><End_Page>836</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>36</Volume><Issue>7</Issue><ISSN_ISBN>1540-8159</ISSN_ISBN><Misc_3>10.1111/pace.12118</Misc_3><Address>Department of Cardiology, Fundacion Jimenez Diaz-Capio, Universidad Autonoma de Madrid, Madrid, Spain. jbenezet@yahoo.es</Address><Web_URL>PM:23510001</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(70)23510001Non randomized prospectively enrolled cohort24Inclusion: symptomatic pts diagnosed w/ IST at single institution (2009-2012) IST defined as resting dtime HR >100; excessive increase in HR w/ activity. Two Holters to confirm ISTExclusion: secondary cause of tachycardiaComparison of baseline to 6 mo of mean, minimal, and maximal HR on Holter, and sxs assessed by SF-36 Health Survey(Secondary – assessment at 1 y and asked to stop treatment and reevaluate by Holter after 1 mo washout)Pts treated w/ ivabradine 5 mg-7.5 mg bidAt 6 mo, maximal HR, mean HR, and minimal HR reduced (p<0.05). SF-36 mean score improved on ivabradine (p<0.001)At 1 y 10 pts accepted to stop ivabradine w/ 2 pts continued to have IST criteriaAt 6 mo ivabradine improved HR indices and sxs. Stopping ivabradine at 1 y showed HR continued to be in normal range in 8/10 pts.Limitation – non randomized, small cohort. Unclear given that pts that stopped the drug at 1 y no longer met criteria for IST that cohort itself may have consisted of pts w/ milder forms of IST or did not truly have IST.Ptaszynski P2013 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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=
ADDIN EN.CITE.DATA (71)22772053Prospective, nonrandomized cohort20(pts treated first w/ metoprolol for 4 wk, then ivabradine for 4 wk)resting HR>100, or mean HR >90 bpm during 24-h HolterAntiarrhythmic therapy discontinued at least 4 wk priorSecondary causes for tachycardia and SHD were excludedAim: Evaluate safety and efficacy of ivabradine compared to metoprololMean and resting HR lower w/ both metoprolol and ivabradine compared to baseline (p<0.001)Exercise capacity (METS) on ETT improved w/ both metoprolol and ivabradine compared to baseline (p<0.001)Sxs reduced more w/ ivabradine compared to metoprolol (p<0.05)70% treated w/ ivabradine were free of sxs related to ISTSide effects: Metoprolol – hypotension in 30%, asymptomatic sinus bradycardia (40-50 bpm) in 25%Ivabradine and metoprolol both reduced HR. Ivabradine better tolerated and improved sxs to greater extentLimitation – short term (4 wk therapy per treatment), small sample size, nonrandomized w/o crossover; no washout period between drugsPtaszynski P2013 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE.DATA (72)23078130Prospective, nonrandomized cohort14Inclusion: IST w/ resting HR ±100 bpm in sitting position and average HR ±90 bpm in 24-h Holter, following successful slow pathway ablation for AVNRT. Pts had also received at least 3 mo of beta blocker therapyExclusion: secondary cause of tachycardia and SHDEvaluation at baseline, 1 mo and 2 mo of therapy w/ ivabradine (5 mg -7.5 mg bid). Resting ECG, 24-h Holter to determine resting, mean, maximum HR, and evaluation of rhythm from Holter corresponding to sxs. ETT performed at baseline, 4 wk and 8 wk Questionnaire to assess sxs before and after 30 and 60 d – EHRA scoreMean resting HR at 30 and 60 d reduced compared to baseline (p<0.001)24-h Holter w/ reduced mean and mean HR during daily activity (p<0.001). Improved exercise capacity w/ ivabradine (p<0.001)Reduced sxs w/ no severe sxs in any pts by 2 moAt 2 mo severe sxs were eliminated in all pts.Limitation – No long term data for efficacy or if IST resolvedPtaszynski P2013 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlB0YXN6eW5za2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE.DATA (73)23426376Prospective, observational cohort20Inclusion: IST w/ resting HR ≥100 bpm in sitting position and average HR ≥90 bpm in 24-h Holter. Pts previously treated w/ beta blockers or verapamil w/o effect or poorly toleratedExclusion: secondary cause of tachycardia and SHD; postural orthostatic tachycardia or h/o orthostatic intoleranceReceived metoprolol succinate 47.5 mg - 95 mg daily for first 4 wk, then ivabradine added 5 mg- 7.5 mg twice daily for additional 4 wk (combination therapy)Holter and ETT performed baseline, 4 wk, and 8 wk.Sxs assessed by questionnaire (EHRA score)Resting HR: baseline 114.4±7.5, at 4 wk 97.3 ±14.4 and 8 wk 90.5 ±13.3 bpm, P<0.001. Mean and maximal HR on Holter monitor also lower in combination therapy compared to either baseline or monotherapy w/ beta blockade (P<0.001).Exercise capacity also increased.After 1 mo of combined therapy no pts reported IST related sxsLimitation – no long term dataKang KT2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbmc8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbmc8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (74)25015944Retrospective chart review (10 pediatric centers)249 ptsPediatric patient with focal AT (median age at diagnosis: 7.2 y), diagnosed based on ECG, 24-h Holter, or event monitor data consistent w/ EP criteria. 168 pts received antiarrhythmic medications (44 different medication combinations), including 154 pts as initial therapy and 14 pts after initial management with catheter ablation. Median duration of first-line therapy was 89 d. Characterization of current management strategies for focal AT in childrenResolution of focal AT in 89% (including spontaneous resolution w/o catheter ablation in 34%).-antiarrhythmic medications used for initial therapy with control of focal AT in 72% (BB were most common, 53%, and most effective, 42%). 34% of the 154 pts w/ first-line therapy along achieved complete suppression or rate control of focal AT. 9 pts had serious AE while on antiarrhythmic medications.-catheter ablation successful in 109 of 134 pts (81%). -53 of 72 pts (74%) presenting at age <3 y had spontaneous resolution (including 50 pts aged <1 y). Spontaneous resolution observed in 18 of 129 pts >5 y.-Cardiomyopathy observed in 28%. 80% of pts with cardiomyopathy had focal AT resolution at last f/u. Lower recurrence rates when electroanatomic mapping techniques are used vs. conventional mapping techniques (16% vs. 35%; p=0.02). Focal AT is managed successfully in most children. Many pts control focal AT with medications, but catheter ablation is used for most pts and successful for all ages.Spontaeous resolution is common, emphasizing delayed ablation in this group.Limitations:-retrospective study, variable f/u duration (median 2.1 y) and available data. Case seriesCallans DJ1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGxhbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGxhbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (75)10334440Case series10 pts(13 procedures)Symptomatic, drug refractory pts referred for RFA of ISTProcedure:- Primarily anatomic-based using ICE guidance, but also activation mapping for confirmation (point-by-point or electroanatomic w/ Carto)- Isoproterenol infusionProcedural success: - - Abrupt decrease (≥30 bpm) in sinus rate during RF lesion delivery- Sudden appearance of superiorly directed p wave morphology (negative P in lead III)- Persistence of these features despite isoproterenol up to 4 mcg/min for at least 30 min following final RF lesion11/13 (85%) procedures successfulLocal circumferential swelling w/ reduction in diameter of SVC-RA junction to 12.6±3.3 mm (24% reduction, p=0.0001)Complications – “none”- Reduction in diameter of SVC-RA junction by ≥30% compared w/ baseline observed in 5 pts; no pts had clinical signs for SVC syndrome.- Small adherent thrombi in 4 pts- 1 pt ppm (after complete SN ablation)Conclusions:- RFA for IST can cause considerable swelling and narrowing of SVC-RA junction. - ICE might be useful in preventing excessive tissue swelling that could lead to complications.Man KC2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Man</Author><Year>2000</Year><RecNum>66</RecNum><IDText>Radiofrequency catheter ablation of inappropriate sinus tachycardia guided by activation mapping</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>66</Ref_ID><Title_Primary>Radiofrequency catheter ablation of inappropriate sinus tachycardia guided by activation mapping</Title_Primary><Authors_Primary>Man,K.C.</Authors_Primary><Authors_Primary>Knight,B.</Authors_Primary><Authors_Primary>Tse,H.F.</Authors_Primary><Authors_Primary>Pelosi,F.</Authors_Primary><Authors_Primary>Michaud,G.F.</Authors_Primary><Authors_Primary>Flemming,M.</Authors_Primary><Authors_Primary>Strickberger,S.A.</Authors_Primary><Authors_Primary>Morady,F.</Authors_Primary><Date_Primary>2000/2</Date_Primary><Keywords>Action Potentials</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Body Surface Potential Mapping</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Recurrence</Keywords><Keywords>Reoperation</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Sinus</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>451</Start_Page><End_Page>457</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>35</Volume><Issue>2</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>S0735-1097(99)00546-X</Misc_3><Address>Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0022, USA</Address><Web_URL>PM:10676693</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(76)10676693Case series29 ptsConsecutive, drug refractory, symptomatic pts who underwent RFA of ISTProcedure: - Activation mapping (point-by-point)- Isoproterenol infusion 1-2 mcg/minProcedural success: Reduction of baseline sinus rate to <90 bpm, and a 20% or greater reduction in sinus rate during infusion of isoproterenol.Procedural success 22/29 (76%) ptsSxs due to IST recurred in 6/22 (27%) at mean f/u 4.4±3 moAdditional procedures in 3 ptsOverall success 19/29 (66%) pts over long-termComplications in 2/29 (7%) pts- Sinus pauses/near-syncope (ppm)- Paralysis of right hemidiaphragmRFA is at best only modestly effective for managing pts w/ IST.Marrouche NF2002 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcnJvdWNoZTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcnJvdWNoZTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+
PFJlY051bT42NzwvUmVjTnVtPjxJRFRleHQ+VGhyZWUtZGltZW5zaW9uYWwgbm9uZmx1b3Jvc2Nv
cGljIG1hcHBpbmcgYW5kIGFibGF0aW9uIG9mIGluYXBwcm9wcmlhdGUgc2ludXMgdGFjaHljYXJk
aWEuIFByb2NlZHVyYWwgc3RyYXRlZ2llcyBhbmQgbG9uZy10ZXJtIG91dGNvbWU8L0lEVGV4dD48
TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9J
RD42NzwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PlRocmVlLWRpbWVuc2lvbmFsIG5vbmZsdW9yb3Nj
b3BpYyBtYXBwaW5nIGFuZCBhYmxhdGlvbiBvZiBpbmFwcHJvcHJpYXRlIHNpbnVzIHRhY2h5Y2Fy
ZGlhLiBQcm9jZWR1cmFsIHN0cmF0ZWdpZXMgYW5kIGxvbmctdGVybSBvdXRjb21lPC9UaXRsZV9Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWFycm91Y2hlLE4uRi48L0F1dGhvcnNfUHJpbWFyeT48
QXV0aG9yc19QcmltYXJ5PkJlaGVpcnksUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlRvbWFzc29uaSxHLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q29sZSxD
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QmFzaCxELjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+RHJlc2luZyxULjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+U2FsaWJhLFcuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BYmR1
bC1LYXJpbSxBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VGNob3UsUC48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNjaHdlaWtlcnQsUi48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5Pkxlb25lbGxpLEYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5OYXRhbGUsQS48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5PjIwMDIv
My8yMDwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5hZG1pbmlzdHJhdGlvbiAmYW1wOyBkb3NhZ2U8
L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFtaW5vcGh5bGxp
bmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Cb2R5IFN1cmZhY2UgUG90ZW50aWFsIE1hcHBpbmc8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW90b25pYyBBZ2VudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5D
YXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCxEcnVnPC9LZXl3b3Jkcz48
S2V5d29yZHM+ZHJ1ZyBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+ZHJ1ZyB0aGVyYXB5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwv
S2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9waHlzaW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+
RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+Rmx1b3Jvc2NvcHk8L0tleXdvcmRzPjxLZXl3b3Jk
cz5Gb2xsb3ctVXAgU3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48
S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+
PEtleXdvcmRzPklzb3Byb3RlcmVub2w8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jk
cz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPnBoeXNpb2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+U2lub2F0cmlhbCBO
b2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5
Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU2ludXM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5UaW1lPC9LZXl3b3Jkcz48S2V5d29yZHM+VHJlYXRtZW50IE91dGNvbWU8L0tleXdv
cmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjEwNDY8L1N0YXJ0
X1BhZ2U+PEVuZF9QYWdlPjEwNTQ8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkogQW0gQ29sbCBDYXJk
aW9sPC9QZXJpb2RpY2FsPjxWb2x1bWU+Mzk8L1ZvbHVtZT48SXNzdWU+NjwvSXNzdWU+PElTU05f
SVNCTj4wNzM1LTEwOTc8L0lTU05fSVNCTj48TWlzY18zPlMwNzM1MTA5NzAyMDE3MDM1PC9NaXNj
XzM+PEFkZHJlc3M+U2VjdGlvbiBvZiBQYWNpbmcgYW5kIEVsZWN0cm9waHlzaW9sb2d5LCBEZXBh
cnRtZW50IG9mIENhcmRpb2xvZ3ksIFRoZSBDbGV2ZWxhbmQgQ2xpbmljIEZvdW5kYXRpb24sIENs
ZXZlbGFuZCwgT2hpbyA0NDE5NSwgVVNBPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjExODk3NDQ5PC9X
ZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPkpvdXJuYWwgb2YgdGhlIEFt
ZXJpY2FuIENvbGxlZ2Ugb2YgQ2FyZGlvbG9neTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3Vy
bmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+SiBBbSBDb2xsIENhcmRpb2w8L2Y+PC9aWl9K
b3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9D
aXRlPjwvUmVmbWFuPm==
ADDIN EN.CITE.DATA (77)11897449Case series39 ptsInclusions:“Debilitating” IST (no prior drugs in 6 pts)Exclusions:- Prior sinoatrial node ablation at other center- F/u <2 y- POTSProcedure: - Mapping at baseline and after isoproterenol (or aminophylline)- Earliest site of activation by 3D electroanatomic mapping targeted- Autonomic testing (10 pts w/ resting HR >100) - tested response to esmolol before ablation - ETT before and after ablation- ICE to verify crista Procedural success:HR drop below 120 bmp during isoproterenol 2 mcg/min alone or in combination w/ aminophylline(Look for SN acceleration during RFA delivery)When endpoint achieved, then recreated 3D map of RAObserve for recovery of HR for 45 to 60 min after last ablationSinoatrial node successfully modified in all pts (100%)Drop in mean HR from 99 ±14 bpm to 72±8 bpm, p<0.01Shift in caudal activation along crista terminalis on 3D map was more pronounced after RFA than during esmolol (23 ±11 mm vs. 7±5 mm, p<0.05)No pt underwent ppm after mean f/u 32±9 mo.21% of pts experienced recurrence of IST and were successfully re-ablatedComplications: SVC syndrome (1 pt), requiring dilation3D mapping provides an effective tool to monitor and guide RFA for IST. (Seems to eliminate excessive destruction of SN and reduce or eliminate risk of complete SN ablation.)Difference in caudal shift seen after esmolol and following sinoatrial node modification suggests that adrenergic hypersensitivity is not the only mechanism responsible for IST.Lin D2007 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051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=
ADDIN EN.CITE.DATA (78)17338721Case series7 ptsMedically refractory IST referred for ablationProcedure:- Non-contact mapping (Endocardial Solutions, Ensite array, 4 mm Chilli Cooled Ablation system) - Isoproterenol 1-10 mcg/min- Intrinsic HR evaluated w/ BB and atropineEndpoint: Decrease in HR of ≥25% off isoproterenol and associated change in P wave morphology in III and AVF from positive to a flat or negative defection c/w more inferior origin Procedural success: 100%Complications: 1 pt ppm (symptomatic junctional bradycardia requiring ppm 2 wk after procedure) – but also had prior RFANon-contact mapping in conjunction w/ saline-cooled ablation for SN modification may provide effective HR control for treatment of IST.Frankel DS2012 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZyYW5rZWw8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
ZWNOdW0+NjM8L1JlY051bT48SURUZXh0PkZyZXF1ZW50IGFkZGl0aW9uYWwgdGFjaHlhcnJoeXRo
bWlhcyBpbiBwYXRpZW50cyB3aXRoIGluYXBwcm9wcmlhdGUgc2ludXMgdGFjaHljYXJkaWEgdW5k
ZXJnb2luZyBzaW51cyBub2RlIG1vZGlmaWNhdGlvbjogYW4gaW1wb3J0YW50IGNhdXNlIG9mIHN5
bXB0b20gcmVjdXJyZW5jZTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlw
ZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjYzPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+RnJl
cXVlbnQgYWRkaXRpb25hbCB0YWNoeWFycmh5dGhtaWFzIGluIHBhdGllbnRzIHdpdGggaW5hcHBy
b3ByaWF0ZSBzaW51cyB0YWNoeWNhcmRpYSB1bmRlcmdvaW5nIHNpbnVzIG5vZGUgbW9kaWZpY2F0
aW9uOiBhbiBpbXBvcnRhbnQgY2F1c2Ugb2Ygc3ltcHRvbSByZWN1cnJlbmNlPC9UaXRsZV9Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+RnJhbmtlbCxELlMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5MaW4sRC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkFuYXN0
YXNpbyxOLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TW91bnRhbnRvbmFraXMs
Uy5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RGl4aXQsUy48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdlcnN0ZW5mZWxkLEUuUC48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5Pkh1dGNoaW5zb24sTS5ELjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+UmlsZXksTS5QLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
TWFyY2hsaW5za2ksRi5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2FsbGFu
cyxELkouPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEyLzg8L0RhdGVfUHJpbWFy
eT48S2V5d29yZHM+QWRyZW5lcmdpYyBiZXRhLUFnb25pc3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5hZHZlcnNlIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5DYXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNoaS1TcXVhcmUgRGlz
dHJpYnV0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+ZGlhZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+ZGlhZ25vc3RpYyB1c2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9naWMg
VGVjaG5pcXVlcyxDYXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ3k8
L0tleXdvcmRzPjxLZXl3b3Jkcz5lcGlkZW1pb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1h
bGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJh
dGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Ib3NwaXRhbHMsVW5pdmVyc2l0eTwvS2V5d29yZHM+PEtl
eXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPklzb3Byb3RlcmVub2w8L0tleXdvcmRz
PjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtl
eXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+TXVsdGl2YXJpYXRlIEFuYWx5
c2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+UGVubnN5bHZhbmlhPC9LZXl3b3Jkcz48S2V5d29yZHM+
cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJlZGljdGl2ZSBWYWx1ZSBvZiBU
ZXN0czwvS2V5d29yZHM+PEtleXdvcmRzPlByZXZhbGVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5Q
cm9wb3J0aW9uYWwgSGF6YXJkcyBNb2RlbHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNl
PC9LZXl3b3Jkcz48S2V5d29yZHM+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5
d29yZHM+UmlzayBBc3Nlc3NtZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzayBGYWN0b3JzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+U2lub2F0cmlhbCBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+c3Vy
Z2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+
VGFjaHljYXJkaWEsU2ludXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGlu
IEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+ODM1PC9TdGFydF9QYWdlPjxFbmRfUGFnZT44Mzk8
L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkogQ2FyZGlvdmFzYyBFbGVjdHJvcGh5c2lvbC48L1Blcmlv
ZGljYWw+PFZvbHVtZT4yMzwvVm9sdW1lPjxJc3N1ZT44PC9Jc3N1ZT48SVNTTl9JU0JOPjE1NDAt
ODE2NzwvSVNTTl9JU0JOPjxNaXNjXzM+MTAuMTExMS9qLjE1NDAtODE2Ny4yMDEyLjAyMjk3Lng8
L01pc2NfMz48QWRkcmVzcz5DYXJkaW92YXNjdWxhciBEaXZpc2lvbiwgRWxlY3Ryb3BoeXNpb2xv
Z3kgU2VjdGlvbiwgSG9zcGl0YWwgb2YgdGhlIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQ
aGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhdmlkLmZyYW5rZWxAdXBocy51cGVubi5lZHU8L0FkZHJl
c3M+PFdlYl9VUkw+UE06MjI0NzE5MDA8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9
IlN5c3RlbSI+Sm91cm5hbCBvZiBjYXJkaW92YXNjdWxhciBlbGVjdHJvcGh5c2lvbG9neTwvZj48
L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+SiBD
YXJkaW92YXNjIEVsZWN0cm9waHlzaW9sLjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dv
cmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+AG==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZyYW5rZWw8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
ZWNOdW0+NjM8L1JlY051bT48SURUZXh0PkZyZXF1ZW50IGFkZGl0aW9uYWwgdGFjaHlhcnJoeXRo
bWlhcyBpbiBwYXRpZW50cyB3aXRoIGluYXBwcm9wcmlhdGUgc2ludXMgdGFjaHljYXJkaWEgdW5k
ZXJnb2luZyBzaW51cyBub2RlIG1vZGlmaWNhdGlvbjogYW4gaW1wb3J0YW50IGNhdXNlIG9mIHN5
bXB0b20gcmVjdXJyZW5jZTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlw
ZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjYzPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+RnJl
cXVlbnQgYWRkaXRpb25hbCB0YWNoeWFycmh5dGhtaWFzIGluIHBhdGllbnRzIHdpdGggaW5hcHBy
b3ByaWF0ZSBzaW51cyB0YWNoeWNhcmRpYSB1bmRlcmdvaW5nIHNpbnVzIG5vZGUgbW9kaWZpY2F0
aW9uOiBhbiBpbXBvcnRhbnQgY2F1c2Ugb2Ygc3ltcHRvbSByZWN1cnJlbmNlPC9UaXRsZV9Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+RnJhbmtlbCxELlMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5MaW4sRC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkFuYXN0
YXNpbyxOLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TW91bnRhbnRvbmFraXMs
Uy5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RGl4aXQsUy48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdlcnN0ZW5mZWxkLEUuUC48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5Pkh1dGNoaW5zb24sTS5ELjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+UmlsZXksTS5QLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
TWFyY2hsaW5za2ksRi5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2FsbGFu
cyxELkouPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEyLzg8L0RhdGVfUHJpbWFy
eT48S2V5d29yZHM+QWRyZW5lcmdpYyBiZXRhLUFnb25pc3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5hZHZlcnNlIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5DYXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNoaS1TcXVhcmUgRGlz
dHJpYnV0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+ZGlhZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+ZGlhZ25vc3RpYyB1c2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9naWMg
VGVjaG5pcXVlcyxDYXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ3k8
L0tleXdvcmRzPjxLZXl3b3Jkcz5lcGlkZW1pb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1h
bGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJh
dGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Ib3NwaXRhbHMsVW5pdmVyc2l0eTwvS2V5d29yZHM+PEtl
eXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPklzb3Byb3RlcmVub2w8L0tleXdvcmRz
PjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtl
eXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+TXVsdGl2YXJpYXRlIEFuYWx5
c2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+UGVubnN5bHZhbmlhPC9LZXl3b3Jkcz48S2V5d29yZHM+
cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJlZGljdGl2ZSBWYWx1ZSBvZiBU
ZXN0czwvS2V5d29yZHM+PEtleXdvcmRzPlByZXZhbGVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5Q
cm9wb3J0aW9uYWwgSGF6YXJkcyBNb2RlbHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNl
PC9LZXl3b3Jkcz48S2V5d29yZHM+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5
d29yZHM+UmlzayBBc3Nlc3NtZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzayBGYWN0b3JzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+U2lub2F0cmlhbCBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+c3Vy
Z2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+
VGFjaHljYXJkaWEsU2ludXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGlu
IEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+ODM1PC9TdGFydF9QYWdlPjxFbmRfUGFnZT44Mzk8
L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkogQ2FyZGlvdmFzYyBFbGVjdHJvcGh5c2lvbC48L1Blcmlv
ZGljYWw+PFZvbHVtZT4yMzwvVm9sdW1lPjxJc3N1ZT44PC9Jc3N1ZT48SVNTTl9JU0JOPjE1NDAt
ODE2NzwvSVNTTl9JU0JOPjxNaXNjXzM+MTAuMTExMS9qLjE1NDAtODE2Ny4yMDEyLjAyMjk3Lng8
L01pc2NfMz48QWRkcmVzcz5DYXJkaW92YXNjdWxhciBEaXZpc2lvbiwgRWxlY3Ryb3BoeXNpb2xv
Z3kgU2VjdGlvbiwgSG9zcGl0YWwgb2YgdGhlIFVuaXZlcnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQ
aGlsYWRlbHBoaWEsIFBBLCBVU0EuIGRhdmlkLmZyYW5rZWxAdXBocy51cGVubi5lZHU8L0FkZHJl
c3M+PFdlYl9VUkw+UE06MjI0NzE5MDA8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9
IlN5c3RlbSI+Sm91cm5hbCBvZiBjYXJkaW92YXNjdWxhciBlbGVjdHJvcGh5c2lvbG9neTwvZj48
L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+SiBD
YXJkaW92YXNjIEVsZWN0cm9waHlzaW9sLjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dv
cmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+AG==
ADDIN EN.CITE.DATA (79)22471900Case series33 ptsConsecutive, drug refractory, symptomaticProcedure: - Evolved from anatomic approach using ICE to EP approach using multi-electrode mapping (St. Jude Ensite or Biosense Webster)- IsoproterenolProcedural endpoint:- Decrease of >25% in resting HR, w/ blunted HR response to isoproterenol and shift of P wave morphology from positive to flat or negative in leads III and AVF - Cranial to caudal shift in site of earliest RA activation pre and post SAN modification was measured using mapping system (later y)F/u 2.0±1.5 y- 18% recurrent IST- 27% developed non-IST tachyarrhythmia (42% had non-IST arrhythmia prior to SAN modification)2 deaths (unrelated) during long-term f/u:- 1 mechanical fall- 1 pulseless electrical activity (end-stage cardiomyopathy)Complications (long-term):12% required ppm for SAN dysfunctionNon-IST tachyarrhythmias are common in pts w/ IST before and after SAN modification, and are often responsible for sxs during f/u.Takemoto M2012 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRha2Vtb3RvPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRha2Vtb3RvPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE.DATA (80)22333369Case series6 ptsConsecutive, drug refractory, “debilitating” Procedure:- Non-contact mapping (St. Jude Ensite)- Break-out sites also identified as earliest sites that showed rS pattern w/ sudden increase in peak negative potential on noncontact unipolar electrogram- Isoproterenol 2-5 mcg/minProcedural endpoint:When break-out sites observed at heart rate >100 bpm moved from the tall P wave zone to the normal P wave zone, w/ and w/o IV isoproterenolF/U 29±2 moProcedural success 6/6 (100%)1 y F/U: 0 recurrences1 ? y: 1/6 pts had recurrence of IST and underwent repeat RFA w/ successAlso showed improvement of HR on Holter, BNP, NYHA functional class, exercise tolerance, and time to achieve HR of 130 bpm on ETT post-ablationComplications: noneNon-contact mapping can be used to safely and effectively treat IST.Huang HD2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Huang</Author><Year>2013</Year><RecNum>64</RecNum><IDText>Stellate ganglion block: a therapeutic alternative for patients with medically refractory inappropriate sinus tachycardia?</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>64</Ref_ID><Title_Primary>Stellate ganglion block: a therapeutic alternative for patients with medically refractory inappropriate sinus tachycardia?</Title_Primary><Authors_Primary>Huang,H.D.</Authors_Primary><Authors_Primary>Tamarisa,R.</Authors_Primary><Authors_Primary>Mathur,N.</Authors_Primary><Authors_Primary>Alam,M.</Authors_Primary><Authors_Primary>Makkar,A.</Authors_Primary><Authors_Primary>Birnbaum,Y.</Authors_Primary><Authors_Primary>Afshar-Kharaghan,H.</Authors_Primary><Date_Primary>2013/11</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>Anesthetics,Local</Keywords><Keywords>diagnosis</Keywords><Keywords>drug effects</Keywords><Keywords>Exercise</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>Nerve Block</Keywords><Keywords>prevention & control</Keywords><Keywords>Stellate Ganglion</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Sinus</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>693</Start_Page><End_Page>696</End_Page><Periodical>J Electrocardiol.</Periodical><Volume>46</Volume><Issue>6</Issue><ISSN_ISBN>1532-8430</ISSN_ISBN><Misc_3>S0022-0736(12)00547-X;10.1016/j.jelectrocard.2012.12.010</Misc_3><Address>Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA. Electronic address: Hdhuang@bcm.edu</Address><Web_URL>PM:23313383</Web_URL><ZZ_JournalFull><f name="System">Journal of electrocardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Electrocardiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(81)23313383Case report using stellate ganglion block134 y old woman previously treated w/ verapamil, beta blockers, clonidineBaseline mean HR (Holter) 104 bpm. Tilt table hr increased from 86 to 104 bpm at 2 min (70 deg)Stellate ganglion block performed (transient Horner syndrome) (right, then left 2 d later)Following bilateral stellate ganglion block, Holter w/ mean HR of 73 bpm.Last f/u at 4 mo w/ resting HR of 87 bpm.Following bilateral stellate ganglion block, Holter w/ mean HR of 73 bpm.Last f/u at 4 mo w/ resting HR of 87 bpm.Mechanisms for lasting effect unclear as anesthetic agent used has half-life of 4-5 hAAD indicates antiarrhythmic drug; AVNRT, atrioventricular nodal reentrant tachycardia; bid, two times per day; BNP, B-type natriuretic peptide; bpm indicates beats per min; c/w, consistent with; ECG, electrocardiogram; EHRA, European Heart Rhythm Association; EP, electrophysiological; ETT, exercise tolerance test; f/u, follow up; h/o, history of; HR, heart rate; ICE, intracardiac echocardiography; IST, inappropriate sinus tachycardia; IV, intravenous; METS, metabolic equivalents; NYHA, New York Heart Association; POTS, postural orthostatic tachycardia syndrome; PPM, prosthesis-patient mismatch; pt, patient; QOL, quality of life; RF, radiofrequency; RFA, radiofrequency ablation; SF, short form; SHD, structural heart disease; SN, sinus node; SVC, superior vena cava; SVC-RA, superior vena cava-right atrial; SVT, supraventricular tachycardia; sx, symptom; w/, with; and w/o, without.Data Supplement 6. Nonrandomized Trials, Observational Studies, and/or Registries of Focal Atrial Tachycardia – Section 4.1 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsGillette PC1977 ADDIN REFMGR.CITE <Refman><Cite><Author>Gillette</Author><Year>1977</Year><RecNum>78</RecNum><IDText>Electrophysiologic and pharmacologic characteristics of automatic ectopic atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>78</Ref_ID><Title_Primary>Electrophysiologic and pharmacologic characteristics of automatic ectopic atrial tachycardia</Title_Primary><Authors_Primary>Gillette,P.C.</Authors_Primary><Authors_Primary>Garson,A.,Jr.</Authors_Primary><Date_Primary>1977/10</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>Digoxin</Keywords><Keywords>drug therapy</Keywords><Keywords>Drug Therapy,Combination</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Heart Atria</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Injections,Intramuscular</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Phenytoin</Keywords><Keywords>Propranolol</Keywords><Keywords>Reserpine</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>571</Start_Page><End_Page>575</End_Page><Periodical>Circulation</Periodical><Volume>56</Volume><Issue>4 Pt 1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:902384</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(82)902384Observational7 children (6 wks to 9 y of age)Sustained automatic AT taken to EP labProgrammed stimulation and drug testing1 responded to digoxin, 3 responded to propranolol and digoxin; diphenylhydantoin in one and reserpine in1Newborn and pediatric population Creamer JE1985 ADDIN REFMGR.CITE <Refman><Cite><Author>Creamer</Author><Year>1985</Year><RecNum>75</RecNum><IDText>Successful treatment of atrial tachycardias with flecainide acetate</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>75</Ref_ID><Title_Primary>Successful treatment of atrial tachycardias with flecainide acetate</Title_Primary><Authors_Primary>Creamer,J.E.</Authors_Primary><Authors_Primary>Nathan,A.W.</Authors_Primary><Authors_Primary>Camm,A.J.</Authors_Primary><Date_Primary>1985/2</Date_Primary><Keywords>Adult</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>drug therapy</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Piperidines</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>164</Start_Page><End_Page>166</End_Page><Periodical>Br.Heart J</Periodical><Volume>53</Volume><Issue>2</Issue><User_Def_5>PMC481734</User_Def_5><ISSN_ISBN>0007-0769</ISSN_ISBN><Web_URL>PM:3966957</Web_URL><ZZ_JournalFull><f name="System">British heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Br.Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(83)3966957Case report3 (23, 33 and 57 y of age, all man)Symptomatic persistent ATAcute (IV) and long term (oral) response to flecainideAll responded acutely and on long term f/u from 3 mo to 3 yCase report demonstrating flecainide is effective in focal AT in selected pts.Kunze KP1986 ADDIN REFMGR.CITE <Refman><Cite><Author>Kunze</Author><Year>1986</Year><RecNum>81</RecNum><IDText>Effect of encainide and flecainide on chronic ectopic atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>81</Ref_ID><Title_Primary>Effect of encainide and flecainide on chronic ectopic atrial tachycardia</Title_Primary><Authors_Primary>Kunze,K.P.</Authors_Primary><Authors_Primary>Kuck,K.H.</Authors_Primary><Authors_Primary>Schluter,M.</Authors_Primary><Authors_Primary>Bleifeld,W.</Authors_Primary><Date_Primary>1986/5</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>Anilides</Keywords><Keywords>Chronic Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Encainide</Keywords><Keywords>Exercise</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart Atria</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Piperidines</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>1121</Start_Page><End_Page>1126</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>7</Volume><Issue>5</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Web_URL>PM:3082957</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(84)3082957Observational5 pts (mean age 37)Chronic symptomatic ectopic AT failed 4 other antiarrhythmic drugs including amiodarone and verapamilAssess acute and long term outcomes w/ encainide and flecainide therapy4/5 pts had complete suppression of AT by encainide and 1/5 had significant reduction at a mean f/u of 8 mo. 3/5 pts did not tolerate encainide. These pts responded to flecainide w/o any side effectsOne of the more comprehensive mechanism-based investigation in human subjects. Differentiation of mechanisms is based on best established criteria although overlaps between reentry and trigger are present; drug response was not specific. It is not apparent whether these were micro- or macro-reentry circuits. Ablation targeted the earliest activation, suggesting micro-reentry.Lucet V1987 ADDIN REFMGR.CITE <Refman><Cite><Author>Lucet</Author><Year>1987</Year><RecNum>416</RecNum><IDText>[Anti-arrhythmia efficacy of propafenone in children. Apropos of 30 cases]</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>416</Ref_ID><Title_Primary>[Anti-arrhythmia efficacy of propafenone in children. Apropos of 30 cases]</Title_Primary><Authors_Primary>Lucet,V.</Authors_Primary><Authors_Primary>Do,Ngoc D.</Authors_Primary><Authors_Primary>Fidelle,J.</Authors_Primary><Authors_Primary>Sidi,D.</Authors_Primary><Authors_Primary>Batisse,A.</Authors_Primary><Authors_Primary>Loth,P.</Authors_Primary><Authors_Primary>Vrancea,F.</Authors_Primary><Authors_Primary>Villain,E.</Authors_Primary><Authors_Primary>Coumel,P.</Authors_Primary><Date_Primary>1987/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Amiodarone</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Calcium</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Failure</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Propafenone</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>1385</Start_Page><End_Page>1393</End_Page><Periodical>Arch.Mal.Coeur Vaiss.</Periodical><Volume>80</Volume><Issue>9</Issue><ISSN_ISBN>0003-9683</ISSN_ISBN><Address>Centre de Cardiologie Infantile du Chateau des Cotes, Les Loges-en-Josas</Address><Web_URL>PM:3122689</Web_URL><ZZ_JournalFull><f name="System">Archives des maladies du coeur et des vaisseaux</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Arch.Mal.Coeur Vaiss.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(85)3122689Observational30 children, age 3 mo to 20 yAll pts treated w/ propafenone for a mean period of 14 moClinical outcomes on propafenone therapyStudy cohorts: chronic AT (8), junctional arrhythmia (9), ventricular arrhythmia (13). Propafeone was “more effective” than amiodarone in 3 pts w/ chronic AT and as effective as amiodarone in 2. Side effects were present in 27%, although “generally well tolerated”.There is significant limitation of the study due to the observational nature of the study design and mix of different arrhythmias.Mehta AV1988PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (86) 3339178Observational10 infants and children; median age 6 mo, range from new born to 7.5 yMet ECG critieria for ectopic ATAcute and long term response to a sequence of drug testing. One pt underwent surgical ablation; one pt underwent catheter ablationDigoxin did not suppress any AT but did slow the ventricular rate by 5-20% in 8 pts. IV propranolol was effective in AT suppression in 3/5 pts; oral propranolol was effective in 2/5. Class Ia and Ib antiarrhythmic agents were not effective in AT suppression and worsened the ventricular rate. IV amiodarone was effective in 3 /4 pts and oral amiodarone was effective in one pt. During f/u (10-28 mo), AT resolved in 4 pts and was well controlled in 4 pts. Surgical and catheter ablation was each performed in one ptsThis small study was conducted in new born and very young childrenColloridi V1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Colloridi</Author><Year>1992</Year><RecNum>74</RecNum><IDText>Oral sotalol in pediatric atrial ectopic tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>74</Ref_ID><Title_Primary>Oral sotalol in pediatric atrial ectopic tachycardia</Title_Primary><Authors_Primary>Colloridi,V.</Authors_Primary><Authors_Primary>Perri,C.</Authors_Primary><Authors_Primary>Ventriglia,F.</Authors_Primary><Authors_Primary>Critelli,G.</Authors_Primary><Date_Primary>1992/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>pharmacology</Keywords><Keywords>Sotalol</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Atrial</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>254</Start_Page><End_Page>256</End_Page><Periodical>Am Heart J</Periodical><Volume>123</Volume><Issue>1</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Misc_3>0002-8703(92)90785-T</Misc_3><Address>Department of Pediatric Cardiology, University of Rome, La Sapienza, Italy</Address><Web_URL>PM:1729843</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(87)1729843Case study5 pediatric ptsEctopic AT was met by ECG criteriaPts failed a mean of three drugsSotalol was added to digoxin; AT was suppressed in all 5 ptsA small case series study showing effect of sotalol on AT in pediatric ptsvon Bernuth G1992 ADDIN REFMGR.CITE <Refman><Cite><Author>von Bernuth</Author><Year>1992</Year><RecNum>91</RecNum><IDText>Atrial automatic tachycardia in infancy and childhood</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>91</Ref_ID><Title_Primary>Atrial automatic tachycardia in infancy and childhood</Title_Primary><Authors_Primary>von Bernuth,G.</Authors_Primary><Authors_Primary>Engelhardt,W.</Authors_Primary><Authors_Primary>Kramer,H.H.</Authors_Primary><Authors_Primary>Singer,H.</Authors_Primary><Authors_Primary>Schneider,P.</Authors_Primary><Authors_Primary>Ulmer,H.</Authors_Primary><Authors_Primary>Brodherr-Heberlein,S.</Authors_Primary><Authors_Primary>Kienast,W.</Authors_Primary><Authors_Primary>Lang,D.</Authors_Primary><Authors_Primary>Lindinger,A.</Authors_Primary><Authors_Primary>.</Authors_Primary><Date_Primary>1992/10</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Amiodarone</Keywords><Keywords>Atrial Appendage</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography,Ambulatory</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Germany</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Propafenone</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Atrial</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>1410</Start_Page><End_Page>1415</End_Page><Periodical>Eur Heart J</Periodical><Volume>13</Volume><Issue>10</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Address>Department of Pediatric Cardiology, RWTH Aachen, Germany</Address><Web_URL>PM:1396817</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(88)1396817Observational21 infants and children Automatic AT was documented by Holter and ECG; 12 were incessant, 7 were repetitive, 2 were undefined; 16/21 were symptomaticAll pts were treated w/ 1-8 antiarrhythmic drugs (median 3)Amiodarone was most effective followed by class Ic drugs: flecainide and propafenone. During a median f/u of 2.5 y (range from 4 mo to 21 y), 12 were in sinus rhythm, 5 were w/o any drugs. Nine pts were still on antiarrhythmic drugs; all were intermittent except oneSmall observational study in the pediatric populationChen SA1994 ADDIN REFMGR.CITE <Refman><Cite><Author>Chen</Author><Year>1994</Year><RecNum>73</RecNum><IDText>Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>73</Ref_ID><Title_Primary>Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation</Title_Primary><Authors_Primary>Chen,S.A.</Authors_Primary><Authors_Primary>Chiang,C.E.</Authors_Primary><Authors_Primary>Yang,C.J.</Authors_Primary><Authors_Primary>Cheng,C.C.</Authors_Primary><Authors_Primary>Wu,T.J.</Authors_Primary><Authors_Primary>Wang,S.P.</Authors_Primary><Authors_Primary>Chiang,B.N.</Authors_Primary><Authors_Primary>Chang,M.S.</Authors_Primary><Date_Primary>1994/9</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>1262</Start_Page><End_Page>1278</End_Page><Periodical>Circulation</Periodical><Volume>90</Volume><Issue>3</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, Veterans General Hospital-Taipei, Taiwan, ROC</Address><Web_URL>PM:8087935</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(89)8087935Observational 36 (57+/-13 y of age)Sustained AT referred to the EP lab for ablationProgrammed stimulation, drug testing, Valsalva, monophasic AP recording and ablation to assess AT mechanisms20/36 had reentrant AT,9/36 triggered (DAD)7/36 automaticImmediate success 40/41 (98%)Recurrence 2/40 (5%) in 18 mons f/u2 failed RF, both were triggeredOne of the earlier more comprehensive mechanism-based investigation in human subjects. Differentiation of mechanisms is based on best established criteria although overlaps between reentry and trigger are present; drug response was not specific. It is not apparent whether these were micro- or macro-reentry circuits. Ablation targeted the earliest activation, suggesting micro-reentry.Engelstein ED1994 ADDIN REFMGR.CITE <Refman><Cite><Author>Engelstein</Author><Year>1994</Year><RecNum>415</RecNum><IDText>Mechanism-specific effects of adenosine on atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>415</Ref_ID><Title_Primary>Mechanism-specific effects of adenosine on atrial tachycardia</Title_Primary><Authors_Primary>Engelstein,E.D.</Authors_Primary><Authors_Primary>Lippman,N.</Authors_Primary><Authors_Primary>Stein,K.M.</Authors_Primary><Authors_Primary>Lerman,B.B.</Authors_Primary><Date_Primary>1994/6</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>New York</Keywords><Keywords>Patients</Keywords><Keywords>pharmacology</Keywords><Keywords>physiopathology</Keywords><Keywords>Potassium</Keywords><Keywords>Research</Keywords><Keywords>Sinoatrial Node</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Sinoatrial Nodal Reentry</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>2645</Start_Page><End_Page>2654</End_Page><Periodical>Circulation</Periodical><Volume>89</Volume><Issue>6</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, New York Hospital-Cornell Medical Center, NY 10021</Address><Web_URL>PM:8205677</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(90)8205677Observational27 pts Automatic (7 pts, age 34+/- 18); sinus node reentry (6 pts, age 58+/- 16); atrial flutter (8 pts, age 62+/- 8); intra-atrial reentry (5 pts, age 70 +/- 8 ); triggered tachycardia (1 pt, age 79)Pts were referred for electrophysiology study (25 pts; 17 for symptomatic SVT, 7 for VT, 1 for syncope) or cardioversion (2 pts w/ atrial flutter)Mechanism of tachycardia was confirmed during electrophysiology study. Response to adenosine was assessed according to EP study determined mechanismsAdenosine terminated all sinus node reentry tachycardia (6/6), triggered tachycardia (1/1). Adenosine transiently suppressed automatic AT (7/7); it had not effect on reentry tachycardia (13/13)These earlier observations established our current understanding of potential mechanisms of AT and drug effects as predicted by underlying mechanisms.Heusch A1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhldXNjaDwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhldXNjaDwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (91)7527342Observational72 children, mean age was 34 mo (range 0-192)All pts were treated w/ propafenone AT or junctional tachycardia were in 10/72 pts (14%). Other arrhythmias including AV reentrant tachycardia (32 pts, 44%), atrial flutter (16 pts, 22%), atrial reentry tachycardia (3 pts, 4%) and ventricular arrhythmias (11 pts, 16%).Propafenone was effective in controlling atrial or junctional ectopic tachycardia in 83%. Of the entire study cohorts, better outcomes were observed in pts w/ normal hearts and in whom onset of arrhythmias was pre-natal.A mix of many different arrhythmias renders interpretation of results difficult. The study population is young children, many w/ congenital heart conditionsJanousek J1998 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphbm91c2VrPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphbm91c2VrPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN EN.CITE.DATA (92)9605053European, retrospective and multicenter study722 infants and children from 27 European centers coordinated by the Working Group on Pediatric Arrhythmias and Electrophysiology of the Association of European Pediatric CardiologistAll pts were treated w/ oral propafenoneSafety outcomesEctopic AT was in 66/722 study cohort. Other arrhythmias included reentrant SVT (388), junctional ectopic tachycardia (39), atrial flutter (21), ventricular premature complexes (140), VT (78) and other (39). 249/722 had SHD. Adverse events included sinus node dysfunction (4), complete heart block (2), SVT proarrhythmia (2), accelerated ventricular rate during atrial flutter (1), ventricular arrhythmias (5), unexplained syncope (1). Cardiac arrest occurred in 6 (0.6%, 2 had WPW, 3 had SHD)A large retrospective multicenter study on the safety of propafenone in the pediatric population. Kalman JM1998 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJl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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (93)9462592Observational23 pts, 27 RA tachycardia17 female, age 41 +/- 14 y; h/o AT suspected from RA; point to point mapping w/ 5 mm tip steerable catheterICE localization of AT origin; outcomes of RFA23/27 localized to RA; 4 were from right superior pulmonary vein; other sites include posterior septum, coronary sinus os, RAA; 18/27 (67%) were on the CT; 26/27 successful ablation (96%); all visualized by ICEVisual confirmation by ICE of ablation site; high prevalence of AT originating from cristae terminalisMarkowitz SM1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcmtvd2l0ejwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hcmtvd2l0ejwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+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ADDIN EN.CITE.DATA (94)10355690Observational30 pts (age 55 +/- 18 y)Referred to EP study for evaluation and treatment of tachycardiaAssess response to adenosine according to EP study determined mechanismsAdenosine terminated 14/17 focal AT and transiently suppressed the other 3 pts. Only 1/13 macrorenetrant tachycardia was terminated by adenosine. The termination occurred in the slow of conduction w/ decrementing properties. Verapamil terminated all of the focal ATs when testedThis study highlighted the challenges remain in differentiating automatic vs. triggered focal AT. The proportion of focal AT terminated by adenosine (presumably due to triggered activity) is significantly different from the report from Englestein 1994, from the same lab.Morton JB2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Morton</Author><Year>2001</Year><RecNum>88</RecNum><IDText>Focal atrial tachycardia arising from the tricuspid annulus: electrophysiologic and electrocardiographic characteristics</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>88</Ref_ID><Title_Primary>Focal atrial tachycardia arising from the tricuspid annulus: electrophysiologic and electrocardiographic characteristics</Title_Primary><Authors_Primary>Morton,J.B.</Authors_Primary><Authors_Primary>Sanders,P.</Authors_Primary><Authors_Primary>Das,A.</Authors_Primary><Authors_Primary>Vohra,J.K.</Authors_Primary><Authors_Primary>Sparks,P.B.</Authors_Primary><Authors_Primary>Kalman,J.M.</Authors_Primary><Date_Primary>2001/6</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Cardiac Catheterization</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Valve Diseases</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>pathology</Keywords><Keywords>physiopathology</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Keywords>Tricuspid Valve</Keywords><Reprint>Not in File</Reprint><Start_Page>653</Start_Page><End_Page>659</End_Page><Periodical>J Cardiovasc Electrophysiol.</Periodical><Volume>12</Volume><Issue>6</Issue><ISSN_ISBN>1045-3873</ISSN_ISBN><Address>Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia</Address><Web_URL>PM:11405398</Web_URL><ZZ_JournalFull><f name="System">Journal of cardiovascular electrophysiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Cardiovasc Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(95)11405398Observational9 pts from 64 consecutive pts underwent RFA for RA AT6 male, 50 +/- 20 y; AT from CT; point to point steerable catheterMapping and localization of AT to CT34/67 (51%) from CT; 8 (12%) from CS; 10 (15%) para-Hisian; 9 (13%) from TA. 8/9 were successfully ablated; 1 was not inducibleAT originating from CT is commonKistler PM2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (96)12821250Observational7 pts/ 172 consecutive pts w/ focal ATAT from mitral annulusPoint to point mappingMapping and ablation need to make note how they figured out where it was coming fromAll mapped to left fibrous trigone and mitral-aortic continuity; P wave low amplitude in precordial leads, biphasic, negative followed by positive; 100% success rateMitral annular origin is less commonKistler PM2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
ZWNOdW0+ODM8L1JlY051bT48SURUZXh0PkVsZWN0cm9waHlzaW9sb2dpY2FsIGFuZCBlbGVjdHJv
Y2FyZGlvZ3JhcGhpYyBjaGFyYWN0ZXJpc3RpY3Mgb2YgZm9jYWwgYXRyaWFsIHRhY2h5Y2FyZGlh
IG9yaWdpbmF0aW5nIGZyb20gdGhlIHB1bG1vbmFyeSB2ZWluczogYWN1dGUgYW5kIGxvbmctdGVy
bSBvdXRjb21lcyBvZiByYWRpb2ZyZXF1ZW5jeSBhYmxhdGlvbjwvSURUZXh0PjxNREwgUmVmX1R5
cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjgzPC9SZWZf
SUQ+PFRpdGxlX1ByaW1hcnk+RWxlY3Ryb3BoeXNpb2xvZ2ljYWwgYW5kIGVsZWN0cm9jYXJkaW9n
cmFwaGljIGNoYXJhY3RlcmlzdGljcyBvZiBmb2NhbCBhdHJpYWwgdGFjaHljYXJkaWEgb3JpZ2lu
YXRpbmcgZnJvbSB0aGUgcHVsbW9uYXJ5IHZlaW5zOiBhY3V0ZSBhbmQgbG9uZy10ZXJtIG91dGNv
bWVzIG9mIHJhZGlvZnJlcXVlbmN5IGFibGF0aW9uPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+S2lzdGxlcixQLk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TYW5k
ZXJzLFAuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5GeW5uLFMuUC48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN0ZXZlbnNvbixJLkguPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5IdXNzaW4sQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PlZvaHJhLEouSy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNwYXJr
cyxQLkIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5LYWxtYW4sSi5NLjwvQXV0
aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwMy8xMC8yMTwvRGF0ZV9QcmltYXJ5PjxLZXl3
b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5hZHZlcnNlIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVy
IEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2hpbGQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5k
aWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jk
cz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwvS2V5d29y
ZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVz
PC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXNvcHJvdGVy
ZW5vbDwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2Rz
PC9LZXl3b3Jkcz48S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlz
aW9wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5QdWxtb25hcnkgVmVpbnM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVvcGVyYXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8
L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PFJlcHJpbnQ+
Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+MTk2ODwvU3RhcnRfUGFnZT48RW5kX1Bh
Z2U+MTk3NTwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+Q2lyY3VsYXRpb248L1BlcmlvZGljYWw+PFZv
bHVtZT4xMDg8L1ZvbHVtZT48SXNzdWU+MTY8L0lzc3VlPjxJU1NOX0lTQk4+MTUyNC00NTM5PC9J
U1NOX0lTQk4+PE1pc2NfMz4xMC4xMTYxLzAxLkNJUi4wMDAwMDk1MjY5LjM2OTg0Ljc1OzAxLkNJ
Ui4wMDAwMDk1MjY5LjM2OTg0Ljc1PC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk
aW9sb2d5LCBSb3lhbCBNZWxib3VybmUgSG9zcGl0YWwsIE1lbGJvdXJuZSwgQXVzdHJhbGlhIDMw
NTA8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTQ1NTczNjE8L1dlYl9VUkw+PFpaX0pvdXJuYWxTdGRB
YmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5DaXJjdWxhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRBYmJy
ZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
ZWNOdW0+ODM8L1JlY051bT48SURUZXh0PkVsZWN0cm9waHlzaW9sb2dpY2FsIGFuZCBlbGVjdHJv
Y2FyZGlvZ3JhcGhpYyBjaGFyYWN0ZXJpc3RpY3Mgb2YgZm9jYWwgYXRyaWFsIHRhY2h5Y2FyZGlh
IG9yaWdpbmF0aW5nIGZyb20gdGhlIHB1bG1vbmFyeSB2ZWluczogYWN1dGUgYW5kIGxvbmctdGVy
bSBvdXRjb21lcyBvZiByYWRpb2ZyZXF1ZW5jeSBhYmxhdGlvbjwvSURUZXh0PjxNREwgUmVmX1R5
cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjgzPC9SZWZf
SUQ+PFRpdGxlX1ByaW1hcnk+RWxlY3Ryb3BoeXNpb2xvZ2ljYWwgYW5kIGVsZWN0cm9jYXJkaW9n
cmFwaGljIGNoYXJhY3RlcmlzdGljcyBvZiBmb2NhbCBhdHJpYWwgdGFjaHljYXJkaWEgb3JpZ2lu
YXRpbmcgZnJvbSB0aGUgcHVsbW9uYXJ5IHZlaW5zOiBhY3V0ZSBhbmQgbG9uZy10ZXJtIG91dGNv
bWVzIG9mIHJhZGlvZnJlcXVlbmN5IGFibGF0aW9uPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+S2lzdGxlcixQLk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TYW5k
ZXJzLFAuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5GeW5uLFMuUC48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN0ZXZlbnNvbixJLkguPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5IdXNzaW4sQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PlZvaHJhLEouSy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNwYXJr
cyxQLkIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5LYWxtYW4sSi5NLjwvQXV0
aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwMy8xMC8yMTwvRGF0ZV9QcmltYXJ5PjxLZXl3
b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5hZHZlcnNlIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVy
IEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2hpbGQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5k
aWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jk
cz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwvS2V5d29y
ZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVz
PC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXNvcHJvdGVy
ZW5vbDwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2Rz
PC9LZXl3b3Jkcz48S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlz
aW9wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5QdWxtb25hcnkgVmVpbnM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVvcGVyYXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8
L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PFJlcHJpbnQ+
Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+MTk2ODwvU3RhcnRfUGFnZT48RW5kX1Bh
Z2U+MTk3NTwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+Q2lyY3VsYXRpb248L1BlcmlvZGljYWw+PFZv
bHVtZT4xMDg8L1ZvbHVtZT48SXNzdWU+MTY8L0lzc3VlPjxJU1NOX0lTQk4+MTUyNC00NTM5PC9J
U1NOX0lTQk4+PE1pc2NfMz4xMC4xMTYxLzAxLkNJUi4wMDAwMDk1MjY5LjM2OTg0Ljc1OzAxLkNJ
Ui4wMDAwMDk1MjY5LjM2OTg0Ljc1PC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk
aW9sb2d5LCBSb3lhbCBNZWxib3VybmUgSG9zcGl0YWwsIE1lbGJvdXJuZSwgQXVzdHJhbGlhIDMw
NTA8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTQ1NTczNjE8L1dlYl9VUkw+PFpaX0pvdXJuYWxTdGRB
YmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5DaXJjdWxhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRBYmJy
ZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (97)14557361Observational27 pts w/ 28 ATsAT from pulmonary veins; 39 +/- 16 y; point to point mapping w/ or w/o LassoMapping and ablationRight superior pumonlary vein 11, left superior pulmonary vein 11, left inferior pulmonary vein 5, right inferior pulmonary vein 1; 26/28 were ostia; 100% successful; 4 recurrence; 25/28 were focal; 3/28 segmental28/172 consecutive focal ATs (16%) from pulmonary vein; high success rate; majority at ostiaGonzalez MD2004 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbnphbGV6PC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbnphbGV6PC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (98)15533857Observational10 pts/35 consecutive pts (28%)AT from mitral-aortic continuityMapping and ablationTachycardia CL 340 msec +/- 56; local e-P – 44 msec +/- 14; 100% successfulProvided a brief discussion on mouse embryo and the specialized conduction system in near the mitral-aortic continuity regionKistler PM2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpc3RsZXI8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (99)15862424Observational13 pts (of 193 w/ focal AT)7 female; 41 +/- 6 y; AT from tricuspid annulus (TA); point to point mappingMapping and localization of AT to TANegative p wave in all inferior leads; negative or isoelectric in V1, positive in avL; 11/13 successfully ablated; 2 noninducible; no recurrence in 25 mo13/ 193 (6.7%) of all AT are from coronary sinus os. Eidher U2006 ADDIN REFMGR.CITE <Refman><Cite><Author>Eidher</Author><Year>2006</Year><RecNum>77</RecNum><IDText>Efficacy and safety of ibutilide for the conversion of monomorphic atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>77</Ref_ID><Title_Primary>Efficacy and safety of ibutilide for the conversion of monomorphic atrial tachycardia</Title_Primary><Authors_Primary>Eidher,U.</Authors_Primary><Authors_Primary>Freihoff,F.</Authors_Primary><Authors_Primary>Kaltenbrunner,W.</Authors_Primary><Authors_Primary>Steinbach,K.</Authors_Primary><Date_Primary>2006/4</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>adverse effects</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Risk Assessment</Keywords><Keywords>Risk Factors</Keywords><Keywords>Safety</Keywords><Keywords>Sulfonamides</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Atrial</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>358</Start_Page><End_Page>362</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>29</Volume><Issue>4</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Misc_3>PACE353;10.1111/j.1540-8159.2006.00353.x</Misc_3><Address>Ludwig-Boltzmann Institute for Arrhythmia Research, Department of Internal Medicine 3 (Cardiology), Wilhelminenspital, Vienna, Austria. dr_eidher@</Address><Web_URL>PM:16650262</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(100)16650262Observational38 pts, 49 episodes of AT“monomorphic” AT, excluded typical atrial flutter and AF; likely included macro-reentry atypical flutterIbutilide conversion to SR in the acute setting19/49 (38.8%) conversionInclusion does not differentiate focal AT from macro-reentry AT; conversion rate appear to be lower than atrial flutter and AF.Ouyang F2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk91eWFuZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk91eWFuZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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 EN.CITE.DATA (101)16814658Observational9 pts; 6 failed previous “para-Hisian” ablation; 6 femaleNCC ATLocation and ablationLocal egram preceded His local A by 12 msec; no H on the ablation catheter; all ablation was successful w/o recurrenceAge 54 +/- 12, range 32-66One of the earlier observational studies reported AT localized to NCC and successfully ablated; highlights mapping NCC early if AT appears para-HisianRoberts-Thomson KC2007 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvYmVydHMtVGhvbXNvbjwvQXV0aG9yPjxZZWFyPjIwMDc8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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvYmVydHMtVGhvbXNvbjwvQXV0aG9yPjxZZWFyPjIwMDc8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ADDIN EN.CITE.DATA (102)17286568Observational10 pts (of 261 w/ focal AT)9 male, 39 =+/- 20 y; AT from RAA; point to point mapping w/ 4 mm tip deflectable catheterMapping and localization to RAAP wave negative in V1; low amplitude or positive in inferior leads; acute success rate in 100%, no recurrenceRAA AT is less common 10/261 (3.8%)Medi C2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1lZGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1lZGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (103)19422986Case control30 pts w/ cardriomyopathy vs. 301 w/o cardiomyopathyAT induced cardiomyopathyOutcome assessmentAT induced caridomyopathy 10% ( 30/301); incessant, younger (39 +/- 22 vs. 51 +/- 17, 60% males vs. 38%), longer tachycardia CL (502 msec vs. 402 msec); LVEF was restored in 97% ptsPrevalence of AT induced cardiomyopathy 10% in all AT pts; RFA is highly successful in restore LVEFLiu X2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpdTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpdTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (104)20797494Case control13 study pts15 PAF/PVI25 PAFAT origination from NCCLocal e-gram, activation sequence, electroanatomical mapping, histology, and P-wave morphologyWide initial activation patter in the right atrium (RA), left atrium (LA) from the parahistian area; earliest activation in the NCC; no atrial myocardium in the NCC; NCC was adjacent to the atrial para-septal tissuePresence of “para-Hisian AT” should raise awareness of close anatomical relationship to atrial –paraseptal tissue and NCCEarly mapping and ablation in the NCC may increase ablation success and reduce complicationsP wave morphology may not differentiate NCC-AT from left atrial or RA paraseptal ATBiviano AB2012 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJpdmlhbm88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJpdmlhbm88L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (105)21967474Observational24, 14 female, age 48+/- 18Focal left atrial AT; no prior h/o AFLocation and short term ablation outcomeCL 347 msec (190-510 msec); CS, septum (5), free wall, MVA, roof, LAA, ligament of Marshall and PV (6)Immediate success 19/22 ATsA good observational study on the distribution of left atrial AT location; contemporary techniques; no major complications; success rate is consistent w/ the literaturede Loma-Osorio A2013 ADDIN REFMGR.CITE <Refman><Cite><Author>de Loma-Osorio</Author><Year>2013</Year><RecNum>76</RecNum><IDText>Spanish Catheter Ablation Registry. 12th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2012)</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>76</Ref_ID><Title_Primary>Spanish Catheter Ablation Registry. 12th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2012)</Title_Primary><Authors_Primary>de Loma-Osorio,Ferrero</Authors_Primary><Authors_Primary>Diaz-Infante,E</Authors_Primary><Authors_Primary>.</Authors_Primary><Authors_Primary>Macias,Gallego A.</Authors_Primary><Date_Primary>2013/12</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Electrophysiology</Keywords><Keywords>methods</Keywords><Keywords>mortality</Keywords><Keywords>Spain</Keywords><Keywords>Tachycardia</Keywords><Reprint>Not in File</Reprint><Start_Page>983</Start_Page><End_Page>992</End_Page><Periodical>Rev.Esp.Cardiol (Engl.Ed)</Periodical><Volume>66</Volume><Issue>12</Issue><ISSN_ISBN>1885-5857</ISSN_ISBN><Misc_3>S1885-5857(13)00274-0;10.1016/j.rec.2013.08.002</Misc_3><Address>Seccion de Electrofisiologia y Arritmias, Sociedad Espanola de Cardiologia, Madrid, Spain. Electronic address: angelferrero@
Seccion de Electrofisiologia y Arritmias, Sociedad Espanola de Cardiologia, Madrid, Spain
Seccion de Electrofisiologia y Arritmias, Sociedad Espanola de Cardiologia, Madrid, Spain</Address><Web_URL>PM:24774111</Web_URL><ZZ_JournalFull><f name="System">Revista espanola de cardiologia (English ed.)</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Rev.Esp.Cardiol (Engl.Ed)</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(106)24774111Spanish registry from 74 centers, voluntary333 of 11042 procedures (3%)Registry included all ablation procedures from 2012Ablation outcomesAcute success rate 284/333 (85.3%); RA 61%, 36% in LA; complications 7/333 (2.1%), 1 permanent pacemaker, 2 vascular, 4 pericardial effusionOne of the few national registriesMano H2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hbm88L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hbm88L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (107)23595943Case control6 study cohorts, 12 controlsAnatomical substrate for NCC-AT vs. AVNRTComparing P wave duration, PQ, intracardiac intervals and local anatomy between NCC-AT and AVNRTP wave duration, PQ and AH intervals were longer in NCC-AT than AVNRT; AS (aortic roof to IVS angle) angle was steeper and IVS was thickerInteresting details, but not sure how useful for clinical practiceAF indicates atrial fibrillation; AP, accessory pathway; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; CL, cycle length; CT, crista terminalis; DAD, delayed afterdepolarizations; ECG, electrocardiogram; EP, electrophysiological; f/u, follow up; h/o, history of; ICE, intracardiac echocardiography; IV, intravenous; IVS, intraventricular septum; LA, left atrial; LAA, left atrial appendage; LVEF, left ventricular ejection fraction; MVA, mitral valve area; NCC, non-coronary cusp; pt, patient; PV, pulmonary vein; RA, right atrial; RF, radiofrequency; RFA, radiofrequency ablation; SHD, structural heart disease; SR, sinus rhythm; SVT, supraventricular tachycardia; VT, ventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 7. Randomized Trials Comparing Multifocal Atrial Tachycardia – Section 4.2 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsArsura E1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Arsura</Author><Year>1988</Year><RecNum>71</RecNum><IDText>A randomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of multifocal atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>71</Ref_ID><Title_Primary>A randomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of multifocal atrial tachycardia</Title_Primary><Authors_Primary>Arsura,E.</Authors_Primary><Authors_Primary>Lefkin,A.S.</Authors_Primary><Authors_Primary>Scher,D.L.</Authors_Primary><Authors_Primary>Solar,M.</Authors_Primary><Authors_Primary>Tessler,S.</Authors_Primary><Date_Primary>1988/10</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>blood</Keywords><Keywords>Clinical Trials as Topic</Keywords><Keywords>Digoxin</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Metoprolol</Keywords><Keywords>Patient Selection</Keywords><Keywords>physiopathology</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>519</Start_Page><End_Page>524</End_Page><Periodical>Am J Med</Periodical><Volume>85</Volume><Issue>4</Issue><ISSN_ISBN>0002-9343</ISSN_ISBN><Misc_3>S0002-9343(88)80088-3</Misc_3><Address>State University of New York, Health Science Center, Brooklyn</Address><Web_URL>PM:3052051</Web_URL><ZZ_JournalFull><f name="System">The American journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(108)3052051?To determine efficacy of verapamil, metoprolol or placebo in MATRandomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of MAT; 13 pts (4 male, 9 female)9 pts verapamil, 9 pts metoprolol10 pts given placebo (2 pts given placebo on both days)MAT diagnosed via ECG. Reversible precipitants of MAT (hypoxia, electrolyte abnormalities, anemia, acidosis, and serum digoxin or theophylline levels outside therapeutic range) – if corrected and pt continued to have MAT, able to participate. CHF; SBP <100 mm Hg; bronchospasm; h/o greater than first-degree heart block; bifascicular block; altered sinus node function; hypersensitivity to either age; estimated survival time <72 h; use of either study agent w/in preceding 72 hConversion to sinus rhythm, a decline in the ventricular rate of ≥15%, or decline in ventricular rate to <100 bpmN/ARepeat physical exam and arterial blood gas values. 2/10 (20%); 4/9 (44%); 8/9 (89%) showed a response to placebo, verapamil, or metoprolol, respectivelyMean slowing of ventricular rate was 3.4, 7.3, and 24.5% for placebo, verapamil, and metoprolol, respectively (p<0.01 for metoprolol vs. placebo). Five pts who had a response to metoprolol had failed to have a response to verapamil.Metoprolol appears more effective than verapamil in treating MAT. Caution must be exercised in selecting ptsMcCord JK 1998 ADDIN REFMGR.CITE <Refman><Cite><Author>McCord</Author><Year>1998</Year><RecNum>70</RecNum><IDText>Usefulness of intravenous magnesium for multifocal atrial tachycardia in patients with chronic obstructive pulmonary disease</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>70</Ref_ID><Title_Primary>Usefulness of intravenous magnesium for multifocal atrial tachycardia in patients with chronic obstructive pulmonary disease</Title_Primary><Authors_Primary>McCord,J.K.</Authors_Primary><Authors_Primary>Borzak,S.</Authors_Primary><Authors_Primary>Davis,T.</Authors_Primary><Authors_Primary>Gheorghiade,M.</Authors_Primary><Date_Primary>1998/1/1</Date_Primary><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>complications</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Infusions,Intravenous</Keywords><Keywords>Lung Diseases,Obstructive</Keywords><Keywords>Magnesium</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Single-Blind Method</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time Factors</Keywords><Reprint>Not in File</Reprint><Start_Page>91</Start_Page><End_Page>93</End_Page><Periodical>Am J Cardiol</Periodical><Volume>81</Volume><Issue>1</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002-9149(97)00809-6</Misc_3><Address>Cardiovascular Division, Henry Ford Hospital, Detroit, Michigan 48202, USA</Address><Web_URL>PM:9462615</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(109)9462615To assess the use of IV Mg for MAT in pts w/ COPDRandomized; 14 pts9 pts received 2 grams over 5 min and 10 g over 5 h5 pts received PlaceboPts w/ COPD and MATCr ≥2.0 mg/dL,intolerance to IV infusionRhythm assessment at 5 hPts treated w/ magnesium had a slowing of heart rate from 130 to 99 beats per minPlacebo- no effect on HR.NSR at end of infusion in 7/9 treated w/ Mg vs. 1/5 w/ placebo.N/AN/AN/ACaregivers not blinded. Small sample size with no control group. BP indicates blood pressure; CI, confidence interval; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; Cr, creatinine; ECG, electrocardiogram; HR, heart rate; IV, intravenous; MAT, multifocal atrial tachycardia; N/A, not applicable; OR, odds ratio; pt, patient; RR, relative risk; and SBP, systolic blood pressure. Data Supplement 8. Nonrandomized Trials, Observational Studies, and/or Registries of Multifocal Atrial Tachycardia – Section 4.2 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsIseri LT1985 ADDIN REFMGR.CITE <Refman><Cite><Author>Iseri</Author><Year>1985</Year><RecNum>92</RecNum><IDText>Magnesium and potassium therapy in multifocal atrial tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>92</Ref_ID><Title_Primary>Magnesium and potassium therapy in multifocal atrial tachycardia</Title_Primary><Authors_Primary>Iseri,L.T.</Authors_Primary><Authors_Primary>Fairshter,R.D.</Authors_Primary><Authors_Primary>Hardemann,J.L.</Authors_Primary><Authors_Primary>Brodsky,M.A.</Authors_Primary><Date_Primary>1985/10</Date_Primary><Keywords>Aged</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>blood</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Humans</Keywords><Keywords>Infusions,Parenteral</Keywords><Keywords>Magnesium</Keywords><Keywords>Magnesium Sulfate</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Potassium</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>789</Start_Page><End_Page>794</End_Page><Periodical>Am Heart J</Periodical><Volume>110</Volume><Issue>4</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Misc_3>0002-8703(85)90458-2</Misc_3><Web_URL>PM:4050650</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(110)4050650Observational88 pts w/ MAT received 7-12 Gm IV mag over 5 hNSRN/AMAT was successfully converted to sinus rhythm or sinus tachycardia in seven pts. MAT rhythm (at slow rate) persisted in one pt.Hazard PB1987 ADDIN REFMGR.CITE <Refman><Cite><Author>Hazard</Author><Year>1987</Year><RecNum>93</RecNum><IDText>Treatment of multifocal atrial tachycardia with metoprolol</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>93</Ref_ID><Title_Primary>Treatment of multifocal atrial tachycardia with metoprolol</Title_Primary><Authors_Primary>Hazard,P.B.</Authors_Primary><Authors_Primary>Burnett,C.R.</Authors_Primary><Date_Primary>1987/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>complications</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Metoprolol</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Pulmonary Gas Exchange</Keywords><Keywords>Respiratory Insufficiency</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Atrial</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>20</Start_Page><End_Page>25</End_Page><Periodical>Crit.Care Med</Periodical><Volume>15</Volume><Issue>1</Issue><ISSN_ISBN>0090-3493</ISSN_ISBN><Web_URL>PM:3792010</Web_URL><ZZ_JournalFull><f name="System">Critical care medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Crit.Care Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(111)3792010 Observational, active treatment w/ metoprolol2525 pts w/ MAT that was complicating severe cardiopulmonary illnessObserved its effect on heart rate and rhythm, BP, and arterial blood gaseAll pts showed slowing of heart rate, averaging 54.0±4.0 bpm (p<0.001)pH and PaCO2 were unaltered; mean PaO2 increased by 12.2 +/- 5.8 torr (p<0.05)Metoprolol is effective in the management of MAT.B indicates blood pressure; bpm, beats per minute; MAT, multifocal atrial tachycardia; N/A, not applicable; NSR, normal sinus rhythm; PaCO2, partial pressure of carbon dioxide; pt, patient; and w/, with. Data Supplement 9. Randomized Trials Comparing Atrioventricular Nodal Re-Entrant Tachycardia – Section 5 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsPharmacological TherapyWaxman HL1981 ADDIN REFMGR.CITE <Refman><Cite><Author>Waxman</Author><Year>1981</Year><RecNum>123</RecNum><IDText>Verapamil for control of ventricular rate in paroxysmal supraventricular tachycardia and atrial fibrillation or flutter: a double-blind randomized cross-over study</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>123</Ref_ID><Title_Primary>Verapamil for control of ventricular rate in paroxysmal supraventricular tachycardia and atrial fibrillation or flutter: a double-blind randomized cross-over study</Title_Primary><Authors_Primary>Waxman,H.L.</Authors_Primary><Authors_Primary>Myerburg,R.J.</Authors_Primary><Authors_Primary>Appel,R.</Authors_Primary><Authors_Primary>Sung,R.J.</Authors_Primary><Date_Primary>1981/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Placebos</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>1</Start_Page><End_Page>6</End_Page><Periodical>Ann Intern Med</Periodical><Volume>94</Volume><Issue>1</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Web_URL>PM:7447203</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(112)7447203Effectiveness of IV verapamil50Group 1 (n=20) w/ AF or flutterGroup 2 (n=30)PSVT (AVNRT in 8 pts), N/APSVT w/ AF, atrial flutter, PSVTN/AControl of ventricular response in group 1, restoration of sinus rhythm in group 2In Group 1 low-dose verapamil (0.075 mg/kg body weight) decreased the mean ventricular rate from 146 to 114 bpm (p<0.01) compared to a decrease of 145 to 132 bpm (p<0.01) after placebo.In Group 2, 14/29 pts converted to sinus rhythm after low-dose verapamil, 9/15 after high-dose verapamil (0.15 mg/kg), and 1/24 after placebo (p<0.01).N/AN/AN/AVerapamil results in a clinically significant slowing of the ventricular response in AF or atrial flutter and is superior to placebo for conversion of PSVT to sinus rhythmMauritson DR1982 ADDIN REFMGR.CITE <Refman><Cite><Author>Mauritson</Author><Year>1982</Year><RecNum>7</RecNum><IDText>Oral verapamil for paroxysmal supraventricular tachycardia: a long-term, double-blind randomized trial</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>7</Ref_ID><Title_Primary>Oral verapamil for paroxysmal supraventricular tachycardia: a long-term, double-blind randomized trial</Title_Primary><Authors_Primary>Mauritson,D.R.</Authors_Primary><Authors_Primary>Winniford,M.D.</Authors_Primary><Authors_Primary>Walker,W.S.</Authors_Primary><Authors_Primary>Rude,R.E.</Authors_Primary><Authors_Primary>Cary,J.R.</Authors_Primary><Authors_Primary>Hillis,L.D.</Authors_Primary><Date_Primary>1982/4</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>409</Start_Page><End_Page>412</End_Page><Periodical>Ann Intern Med</Periodical><Volume>96</Volume><Issue>4</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Web_URL>PM:7065555</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(23)7065555Effectiveness and safety of oral verapamil11Verapamil 240 mg/d followed by 480 mg/d (n=11)PlaceboSymptomatic PSVT, ≥2 episodes/mo, ascertained by ECGAVNRT(n=7)AVRT(n=2 w/ WPW, n=3 w/ concealed AP)CHF, severe hypertension, hypotension, VHD or CHD, renal/hepatic failure, SSS, AV block, atrial flutter, AF, AADsEpisodes/wk (diary, Holter)Verapamil 0.1±0.1 ,0.3 ±0.5Placebo 0.3±0.3 ,0.7 ±0.7Duration (min) (diary, Holter)Verapamil 3±3 ,1±2Placebo 27±5 ,67±111Minor AEs in 6 pts on verapamil5 pts required a total of 35 cardioversions for sustained tachycardia, 2 during verapamil, 33 during placebo (p<0.001)PES performed at end of study to induce tachycardia. Caused sustained tachycardia in 9 on placebo, 2 on verapamil (p<0.01) N/Ap<0.05 for primary endpointOral verapamil safe and effective.Small sample size.Unclear which pt withdrew, so numbers of AVNRT vs. AVRT may be similar (i.e., 6 vs. 5). Winniford MD1984 ADDIN REFMGR.CITE <Refman><Cite><Author>Winniford</Author><Year>1984</Year><RecNum>8</RecNum><IDText>Long-term therapy of paroxysmal supraventricular tachycardia: a randomized, double-blind comparison of digoxin, propranolol and verapamil</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>8</Ref_ID><Title_Primary>Long-term therapy of paroxysmal supraventricular tachycardia: a randomized, double-blind comparison of digoxin, propranolol and verapamil</Title_Primary><Authors_Primary>Winniford,M.D.</Authors_Primary><Authors_Primary>Fulton,K.L.</Authors_Primary><Authors_Primary>Hillis,L.D.</Authors_Primary><Date_Primary>1984/11/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Clinical Trials as Topic</Keywords><Keywords>Digoxin</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Propranolol</Keywords><Keywords>Random Allocation</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>1138</Start_Page><End_Page>1139</End_Page><Periodical>Am J Cardiol</Periodical><Volume>54</Volume><Issue>8</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Web_URL>PM:6388299</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(24)6388299Effect of AV nodal blockers for long-term therapy of PSVT11One mo of:Digoxin 0.375 mg/dPropranolol 240 mg/dVerapamil 480 mg/dDirect comparison between all 3, w/ one wk of placebo washoutSymptomatic PSVT, ≥2 episodes/mo, ascertained by ECGECG evidence of preexcitationEpisodes and duration (ascertained by diary and weekly 24-h Holter), adverse effects, SDCs of each drugEpisodes/wk (diary, Holter)Digoxin 2.3±3.1, 1.9±2.9Propranolol 1.5±2.3, 0.2±0.6Verapamil 2.9±5.7, 0.6±1.6Duration (min) (diary, Holter)Digoxin 75±164, 47±157Propranolol 60±112, 1±1Verapamil 56±148, 1±1Mild side effects in 3/11 pts w/ digoxin and propranolol, and 5/11 w/ verapamil. All SDCs w/in normal reference range.?N/A?p=NSOnly verapamil had been studied in RCT prior to this (above), and given its proven efficacy, authors felt no need for placebo. Small series of pts.Unclear mechanism of PSVT (authors speculate all pts w/ AVRNT or ORT w/ concealed conduction. Yeh SJ1984 ADDIN REFMGR.CITE <Refman><Cite><Author>Yeh</Author><Year>1985</Year><RecNum>124</RecNum><IDText>Termination of paroxysmal supraventricular tachycardia with a single oral dose of diltiazem and propranolol</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>124</Ref_ID><Title_Primary>Termination of paroxysmal supraventricular tachycardia with a single oral dose of diltiazem and propranolol</Title_Primary><Authors_Primary>Yeh,S.J.</Authors_Primary><Authors_Primary>Lin,F.C.</Authors_Primary><Authors_Primary>Chou,Y.Y.</Authors_Primary><Authors_Primary>Hung,J.S.</Authors_Primary><Authors_Primary>Wu,D.</Authors_Primary><Date_Primary>1985/1</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrioventricular Block</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Benzazepines</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Cardiac Catheterization</Keywords><Keywords>Diltiazem</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Drug Therapy,Combination</Keywords><Keywords>Electric Countershock</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Propranolol</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>104</Start_Page><End_Page>109</End_Page><Periodical>Circulation</Periodical><Volume>71</Volume><Issue>1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:3964710</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(113) 3964710 Effect of diltiazem and propranolol as pill-in-the-pocket15Combination diltiazem 120 mg/propranolol 160 mg vs. placebosDirect comparison on 2 consecutive dInducible PSVTAVRT (n=13)AVNRT (n=2)N/AW/ placebo PSVT lasted 164±89 min; 4 pts had spontaneous conversion. W/ diltiazem and propranolol PSVT lasted 39±49 min (p<.001). 14 pts had spontaneous conversion in an average of 27 ±15 min. None of the 14 pts had electrical reinduction of sustained PSVT after conversion.Outpatient f/u w/ 50/51 conversion of PSVT w/in 21±16 min, f/u of 5.6 mo. The heart rate was 87±16 bpm before and59±10 bpm at 90 min after diltiazem and propranolol(p<0.001). The systolic and diastolic pressureswere, respectively, 111±11 and 77±10 mmHg before and 88 + 9 and 66 + 9 mm Hg after diltiazem and propranolol (p<0.001)N/AN/ASingle dose of diltiazem/propranolol terminated acute PSVTLimited due to EP study efficacy and low numbers of AVNRT pts. Not placebo controlled. Anderson S1986 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZGVyc29uPC9BdXRob3I+PFllYXI+MTk4NjwvWWVhcj48
UmVjTnVtPjU8L1JlY051bT48SURUZXh0PkNvbXBhcmlzb24gb2YgdGhlIGVmZmljYWN5IGFuZCBz
YWZldHkgb2YgZXNtb2xvbCwgYSBzaG9ydC1hY3RpbmcgYmV0YSBibG9ja2VyLCB3aXRoIHBsYWNl
Ym8gaW4gdGhlIHRyZWF0bWVudCBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5YXJyaHl0aG1pYXMu
IFRoZSBFc21vbG9sIHZzIFBsYWNlYm8gTXVsdGljZW50ZXIgU3R1ZHkgR3JvdXA8L0lEVGV4dD48
TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9J
RD41PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+Q29tcGFyaXNvbiBvZiB0aGUgZWZmaWNhY3kgYW5k
IHNhZmV0eSBvZiBlc21vbG9sLCBhIHNob3J0LWFjdGluZyBiZXRhIGJsb2NrZXIsIHdpdGggcGxh
Y2VibyBpbiB0aGUgdHJlYXRtZW50IG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHlhcnJoeXRobWlh
cy4gVGhlIEVzbW9sb2wgdnMgUGxhY2VibyBNdWx0aWNlbnRlciBTdHVkeSBHcm91cDwvVGl0bGVf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkFuZGVyc29uLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5CbGFuc2tpLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5CeXJkLFIuQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkRhcyxHLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RW5nbGVyLFIuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5MYWRkdSxBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+TGVlLFIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5SYWpmZXIsUy48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNjaHJvZWRlcixKLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+U3RlY2ssSi5ELjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+LjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk4Ni8xPC9EYXRlX1By
aW1hcnk+PEtleXdvcmRzPkFkcmVuZXJnaWMgYmV0YS1BbnRhZ29uaXN0czwvS2V5d29yZHM+PEtl
eXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jk
cz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFycmh5dGhtaWFzLENhcmRpYWM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5DbGluaWNhbCBUcmlhbHMgYXMgVG9waWM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5jb21wbGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+RG91YmxlLUJsaW5kIE1l
dGhvZDwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRz
PkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jk
cz5IZWFydCBWZW50cmljbGVzPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48
S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPlByb3Bhbm9sYW1pbmVzPC9LZXl3b3Jk
cz48S2V5d29yZHM+UmFuZG9tIEFsbG9jYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNh
cmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PFJlcHJp
bnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+NDI8L1N0YXJ0X1BhZ2U+PEVuZF9Q
YWdlPjQ4PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5BbSBIZWFydCBKPC9QZXJpb2RpY2FsPjxWb2x1
bWU+MTExPC9Wb2x1bWU+PElzc3VlPjE8L0lzc3VlPjxJU1NOX0lTQk4+MDAwMi04NzAzPC9JU1NO
X0lTQk4+PFdlYl9VUkw+UE06Mjg2ODY0NTwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFt
ZT0iU3lzdGVtIj5BbWVyaWNhbiBoZWFydCBqb3VybmFsPC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpa
X0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5BbSBIZWFydCBKPC9mPjwvWlpfSm91
cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0
ZT48L1JlZm1hbj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZGVyc29uPC9BdXRob3I+PFllYXI+MTk4NjwvWWVhcj48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ADDIN EN.CITE.DATA (25)2868645Efficacy of esmolol in treatment of PSVT71Multicenter, double-blind, partial-crossover studyEsmolol (n=36)Placebo (n=35)?“SVT” (HR>120)Note: AVNRT in 18% of subjectsVHD, AV block, SSS, significant electrolyteabnormality,precluding treatment w/ beta blockade, bronchialasthma, ventricular arrhythmias requiring drug therapy,cardiogenic shock, CHF (NYHA III-IV), renal or hepatic dysfunction, drug or alcohol abuse, on other beta-adrenergic blockers or calcium channelblockers w/in two half-lives of study entryTherapeutic response: ≥20% reduction in HR, HR<100 bpm, or conversion to NSR.Therapeutic response to esmolol during the initial treatment period (72%) similar when esmolol was given as a second agent4 pts (6%) converted to NSRIn the 80% therapeutic response lost w/in 30 min following discontinuation of esmolol infusionHypotension which occurred in12% on esmolol, 2% w/ placebo.N/Ap=NSRapid onset and short ofaction of esmolol offer safe, effective therapy for acute treatment of pts w/ PSVT. Low numbers of pts w/ AVNRT.*DiMarco JP1990 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (114)2193560Evaluate dose responses of adenosine in terminating PSVT359 total in both protocols(n=201)Sequential IV bolus doses of adenosine (3, 6, 9, 12 mg) (n=137)Saline placebo(n=64)PSVTSevere CHF, unstable angina, recent MI, severe valvular regurgitation, intracardiac shunts, sleep apnea, current methylxanthine or dipyridamole useAdenosine terminated acute episodes of PSVT, vs. placebo: 3 mg: 35.2% vs. 8.9%6 mg 62.3% vs. 10.7%9 mg: 80.2% vs. 14.3%12 mg: 91.4% vs. 16.1%Adenosine caused mild, transient side effects in 36% of pts (flushing, chest pain/pressure, hypotension, dyspnea)N/A?p<0.0001Overall efficacy of adenosine high, especially w/ increasing doses*DiMarco JP1990 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (114) 2193560Compare adenosine to verapamil in terminating PSVT359 total in both protocols(n=158)6-12 mg adenosine (n=77)5-7.5 mg of verapamil.(n=81)?PSVTSevere CHF, unstable angina, recent MI, severe valvular regurgitation, intracardiac shunts, sleep apnea, current methylxanthine or dipyridamole useCumulative response rates Adenosine:6 mg: 57.412 mg: 93.4% Verapamil:5 mg: 81.3% 7.5 mg: 91.4%Adenosine caused mild, transient side effects in 36% of pts?N/AN/AOverall efficacy of adenosine is similar to verapamil, but onset of action is more rapid.Henthorn RW1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Henthorn</Author><Year>1991</Year><RecNum>11</RecNum><IDText>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>11</Ref_ID><Title_Primary>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Henthorn,R.W.</Authors_Primary><Authors_Primary>Waldo,A.L.</Authors_Primary><Authors_Primary>Anderson,J.L.</Authors_Primary><Authors_Primary>Gilbert,E.M.</Authors_Primary><Authors_Primary>Alpert,B.L.</Authors_Primary><Authors_Primary>Bhandari,A.K.</Authors_Primary><Authors_Primary>Hawkinson,R.W.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Date_Primary>1991/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>Drug Administration Schedule</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>119</Start_Page><End_Page>125</End_Page><Periodical>Circulation</Periodical><Volume>83</Volume><Issue>1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Division of Cardiology, Christ Hospital, Cincinnati, Ohio 45219</Address><Web_URL>PM:1898640</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(26)1898640Flecainide for treatment of symptomatic PSVT (≥2 episodes)348-wk crossover (after four episodes of PSVT or end of treatment period)?Flecainide(n=34)Placebo(n=34)PSVT Syncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) Freedom from symptomatic PSVT at 60 d:79% events vs. 15% (p<0.001)Flecainide slowed symptomatic PSVT HR to 143±12 bpm from 178 ±12 on placebo in 7 pts who had events in the placebo and flecainide treatment phases(p<0.02)Significantly more side effects w/ flecainide (p<0.05)Flecainide vs. placebo:Recurrence:8/34 vs. 29/34 (p<0.001).Median time to first event: 55 vs. 11 d (p<0.001)Median interval between episodes >55 vs. 12 (p<0.001)N/ADespite participationof 19 medical centers, only 34 pts completed entire protocol and provided analyzable data.All pts tolerated flecainide, limiting generalizability.Transtelephonic monitoring does not permit assessment of proarrhythmia6/34 w/ AVNRT, confirmed by EP study, and 18/34 w/ unknown mechanism.Pritchett EL1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pritchett</Author><Year>1991</Year><RecNum>10</RecNum><IDText>Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>10</Ref_ID><Title_Primary>Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>DaTorre,S.D.</Authors_Primary><Authors_Primary>Platt,M.L.</Authors_Primary><Authors_Primary>McCarville,S.E.</Authors_Primary><Authors_Primary>Hougham,A.J.</Authors_Primary><Date_Primary>1991/2</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>297</Start_Page><End_Page>303</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>17</Volume><Issue>2</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Address>Duke University Medical Center, Durham, North Carolina 27710</Address><Web_URL>PM:1899432</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(27)1899432 Dose-response efficacy of flecainide in patents w/ PSVT, PAF, paroxysmal atrial flutter42Flecainide given in ascending order (25501001150 mg twice daily)PSVT(n=14, Group 1)PAF or parosysmal atrial flutter(n=28, Group 2)Placebo inserted at random (alternating w/ flecainide) at 30 d intervalsPSVT, PAF, or paroxysmal atrial flutterSyncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) .Among 14 pts in Group 1 who qualified for efficacy analysis, 4 (29%) had no tachycardia while taking placebo. Number w/ no tachycardia increased w/ progressively larger flecainide doses; w/ the 150 mg twice daily dose, 12 (86%) of 14 pts had no tachycardia (p<0.01 for overall differences among all treatments).Noncardiac adverse experiences were leading cause of premature study discontinuation during flecainide treatment periods (5 pts in Group 1 and 6 pts in Group 2).N/AN/ASmall sample size, short treatment period. Pritchett EL1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pritchett</Author><Year>1991</Year><RecNum>9</RecNum><IDText>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>9</Ref_ID><Title_Primary>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</Title_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>McCarthy,E.A.</Authors_Primary><Authors_Primary>Wilkinson,W.E.</Authors_Primary><Date_Primary>1991/4/1</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Statistics as Topic</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>539</Start_Page><End_Page>544</End_Page><Periodical>Ann Intern Med</Periodical><Volume>114</Volume><Issue>7</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Address>Duke University Medical Center, Durham, North Carolina</Address><Web_URL>PM:2001087</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(28)2001087Oral propafenone to prevent symptomatic PSVTRandomized, double-blind, placebo-controlled, crossover phase, w/ each treatment period lasting up to 60 d.23Propafenone (n=23)Placebo(n=23)PSVT(n=14) PAF(n=9)Angina during tachycardia, pulmonary edema, neurologicsxs. PAF w/ WPW syndrome, on AADsCompared w/ placebo, propafenone caused an increase in time to first recurrence of arrhythmia (p=0.004)PSVT:p=0.03PAF:p=0.06.Cardiac AEs occurred only in pts w/ PAF (9/11): 2 w/ prolonged episode of AF, 1 w/ atrial flutter w/ a mean ventricularrate of 263 bpm recorded using the telephone monitor.N/AN/APropafenone efficacious in treating PSVT and PAF.Major limitation in not knowing how many pts had AVNRT. .Dougherty AH1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Dougherty</Author><Year>1992</Year><RecNum>122</RecNum><IDText>Acute conversion of paroxysmal supraventricular tachycardia with intravenous diltiazem. IV Diltiazem Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>122</Ref_ID><Title_Primary>Acute conversion of paroxysmal supraventricular tachycardia with intravenous diltiazem. IV Diltiazem Study Group</Title_Primary><Authors_Primary>Dougherty,A.H.</Authors_Primary><Authors_Primary>Jackman,W.M.</Authors_Primary><Authors_Primary>Naccarelli,G.V.</Authors_Primary><Authors_Primary>Friday,K.J.</Authors_Primary><Authors_Primary>Dias,V.C.</Authors_Primary><Date_Primary>1992/9/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Cardiology</Keywords><Keywords>Diltiazem</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>587</Start_Page><End_Page>592</End_Page><Periodical>Am J Cardiol</Periodical><Volume>70</Volume><Issue>6</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Division of Cardiology, University of Texas Medical School, Houston 77225</Address><Web_URL>PM:1510006</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(115)1510006Efficacy and safety of IV diltiazem87AVNRT (n=25)AVRT (n=60)AT (n=2)DiltiazemPlaceboInduction of PSVT w/ PES, requiredto have a rate of 120 bpm and to persist for 115 min.Pts w/ severe congestive heartfailure, sinus node dysfunction, pregnancy, myocardialinfarction w/in 2 wk of study, or hypotension (SBP <90 mm Hg)Conversion to sinus rhythm occurred in 4 of 14 pts (29%) w/ 0.05 mg/kg of diltiazem, 16 of 19 (84%) w/ 0.15 mg/kg, 13 of 13 (100%) w/ 0.25 mg/kg, and 14 of 17 (82%) w/ 0.45 mg/kg compared w/ 6 of 24 (25%) treated w/ placebo. Conversion rates in groups receiving doses of 0.15 to 0.45 mg/kg of diltiazem were superior to that in the placebo group (p<0.001). Time to conversion was 3.0±2.6 min in responding diltiazem pts compared w/ 5.9±6.1 min in responding control pts.N/AMost frequent adverse response to diltiazem was hypotension (7 of 63 pts); however, only 4 pts had sxs related to hypotension.N/AIV diltiazem in doses of 0.15, 0.25 and 0.45 mg/kg is effective and safe for acute management of PSVT.Anderson JL1994 ADDIN REFMGR.CITE <Refman><Cite><Author>Anderson</Author><Year>1994</Year><RecNum>12</RecNum><IDText>Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>12</Ref_ID><Title_Primary>Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Anderson,J.L.</Authors_Primary><Authors_Primary>Platt,M.L.</Authors_Primary><Authors_Primary>Guarnieri,T.</Authors_Primary><Authors_Primary>Fox,T.L.</Authors_Primary><Authors_Primary>Maser,M.J.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Date_Primary>1994/9/15</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Confounding Factors (Epidemiology)</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time Factors</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>578</Start_Page><End_Page>584</End_Page><Periodical>Am J Cardiol</Periodical><Volume>74</Volume><Issue>6</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Department of Medicine, University of Utah, Salt Lake City</Address><Web_URL>PM:8074041</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(29)8074041 Long-term efficacy of flecainide (≥6 mo)49PSVT(n=21)PAF(n=28)FlecainidePlaceboPts enrolled from 3 prior studies evaluating short-term flecainide efficacy (2 above, Pritchett and Henthorn—one [Anderson, 1989]) not tabulated above due to PAF-only population)Syncope, angina, or transient cerebral events during PSVT, second or third degree AV block or had CHF (NYHA III-IV) -Number of pts w/o attacks-Time to first attack-Interval between attacks-Average frequency of attacks,-Ventricular rate during attacks.PSVT pts:Of 17 efficacy evaluable pts, 14 (82%) had no SVT attacks during the chronic efficacy study compared w/ 4 (24%) w/ no attacks during placebo therapy at baseline (p=0.013).Time to first arrhythmia attack and time between attacks increasedduring chronic therapy w/ flecainide compared w/ placebo treatment (p=0.008 and p=0.012, respectively)Rates of attack/d not significantly different (p=0.130)No PSVT pts w/ ventricular arrhythmiasNo pt experiencedproarrhythmia, MI, or died during chronic efficacy study.N/AN/ASupports flecainide for chronic therapy of PSVT.Small numbers of pts w/ PSVT, and PSVT not specifically defined.Chimienti M1995 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN EN.CITE.DATA (30)8682031Compare the long-term safety of flecainide and propafenone335AVNRT:flecainide 100 mg (n = 72) PAF:flecainide 200 mg (n = 97) AVNRT:propafenone 450 mg (n=63)PAF: propafenone 450 mg (n=103).PAF(n-200)AVNRT(n=135)LVEF <35%, AV block, QRS >140 msec, SSS, persistent AF (episodes >72 h), VT (episodes >30 sec), NYHA III-IV, ischemic heart disease, hypertrophic cardiomyopathy, hypotension, valvular disease, renal/hepatic insufficiency, thyroid disease, AADsITT analysisPSVT:93% for flecainide and 86% for propafenone (p=0.24)PAF:77% for flecainide and 75% for propafenone (p=0.72)12 pts on flecainide reported 16 cardiac AEs, of whom six discontinued the treatment. 7 propafenone pts had 8 cardiac AEs, of whom 5 discontinued the treatment.(1 case of VT on propafenone2 cases of AF w/ rapid ventricular response on flecainideN/AN/ABoth flecainide and propafenone were safe in the long-term treatment of pts w/ PSVT.Limited in that only one-third of pts w/ AVNRT. UK Propafenone PSVT Study Group1995 ADDIN REFMGR.CITE <Refman><Cite><Year>1995</Year><RecNum>14</RecNum><IDText>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>14</Ref_ID><Title_Primary>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</Title_Primary><Date_Primary>1995/11/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>2550</Start_Page><End_Page>2557</End_Page><Periodical>Circulation</Periodical><Volume>92</Volume><Issue>9</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:7586356</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(31)7586356Efficacy and tolerability of propafenone at 600 and 900 mg daily doses (given twice daily).2 consecutive crossover periods100Propafenone 300 mg bidPropafenone 300 mg tidPlaceboPSVT(n=52) PAF(n=48) 75 pts in low-dose phase:45 PSVT, 30 PAF59 pts advanced to high-dose phase:34 PSVT, 25 PAF ≥2 symptomatic episodes by transtelephonic monitoring PSVT w/ hemodynamic collapse, LVEF ≤25%, recent MI or unstable angina; hepatic/renal failure, SSS, AV block, AADs, female pts of childbearing potential, COPD, myasthenia gravis.Placebo vs. propafenone:Relative risks, PSVT, low-dose:Arrhythmia recurrence or AE6.8 (95% CI: 2.2-21.2; p<0.001)Arrhythmia recurrence7.4 (95% CI: 2.3-23.3; p<0.001)Relative risks, PSVT, high-dose:Arrhythmia recurrence or AE2.2 (95% CI: 0.9-5.3; p=NS)Arrhythmia recurrence15.0 (95% CI: 2.0-113; p=0.009)More pts experienced more adverse events during propafenone (900 mg>600 mg). Most common adverse events during PSVT and PAF groups were related to the gastrointestinal and neuropsychiatric systems. Total numbers of adverse events on propafenone were 46 and 56 in the low-dose and high-dose PSVT group and 67 and 74 in the low-dose and high-dose PAF groups, respectively.1 episode of wide-complex tachycardia was documented during propafenone therapyN/APropafenone at 600 mg is effective and well tolerated. A larger dose of 900 mg causes more adverse effects but may be more effective in those who can tolerate it.Sequential design (not randomized after low-dose phase) so population is not generalizable at 900 mg dose. Not powered for mortality.Limited in that PSVTs included AVNRT, AT, or AVRT.Wanless RS1997 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbmxlc3M8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbmxlc3M8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (33)9124166 Sotalol in treatment of PSVT126 Sotalol 80 mg(n=35)AVNRT (23%)Sotalol 160 mg(n=46)AVNRT (22%)Placebo(n=45)AVNRT (24%)Recurrent symptomatic PSVT were eligible for enrollment. AVNRTPAFParoxysmal atrial flutterAVRTParoxysmal AT Decompensated CHF, asthma, chronic obstructive airways disease, second degree or third degree AV block, recent myocardial infarction (<1 mo), recent coronary artery bypass graft surgery (<2 mo), unstable angina pectoris, bradycardia (<50 bpm), SSS, prolonged QTc interval (>0.45 sec), systemic hypertension (diastolic pressure >115 mm Hg), electrolyte imbalance, AADsTime to recurrence of PSVT was less compared w/ placebo when receiving sotalol 80 mg (p=0.04) and sotalol 160 mg (p=0.0009). On subanalysis, sotalol was shown to be effective in the prophylaxis of both PAF (p=0.03) and paroxysmal reentrant arrhythmias (p=0.0003).No deaths, cases of ventricular proarrhythmia, CHF. Treatment of pts receiving sotalol were discontinued because of typical BB side effects, including bradycardia, dyspnea, and fatigue.N/AN/ASotalol efficacious in the prophylaxis of PSVT. Study limited due to grouping of PSVTs.Gupta A 1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1cHRhPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1cHRhPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (35)10778689IV diltiazem and esmolol in acute therapy of PSVT32 (initially 50 enrolled, but trial stopped early)Hemodynamically tolerated PSVTN/ATwo sequential doses w/ a 5 min interval of either drug were administered before crossover. Diltiazem was given in a dose of 0.25 mg/kg while the esmolol dose was 0.5 mg/kg.N/ADiltiazem terminated PSVT in all the 16 pts in whom it was given as the first drug. The 12 pts who did not respond to esmolol were also effectively treated w/ diltiazem. 28/28 pts responded to diltiazem while only 4/16 pts responded to esmolol (p<0.001)Of the 28 pts who responded to diltiazem, in 13 pts the second bolus of diltiazem worked after the first one had failed.No significant adverse effects were seen.N/AN/AIV diltiazem is highly effective and safe for terminating PSVT. When the first bolus is ineffective, the second bolus given after 5 min usually succeeds. Esmolol in the dose of 0.5 mg/kg has poor efficacy for terminating PSVT, even when 2 boluses are administered.Alboni P2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsYm9uaTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJl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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsYm9uaTwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (36)11216977Pill-in-the-pocket approach to management of PSVT, well-tolerated33Flecainide (n=33)Diltiazem/ propranolol (n=33)Placebo (n=33)AVNRT and AVRT confirmed by EP studyWell-tolerated (no sxs of dyspnea, syncope, presyncope, no interference w/ normal activitiesInfrequent (≤5 episodes/y) w/ ≥1 ED visit/yPSVT documented by ECGPreexcitation, CAD, resting bradycardia <50 bpm, LVEF <50%, h/o HF, severe “general diseases,” recent MI or CVA, acute illness, need for AADs, h/o sustained atrial/ventricular tachyarrhythmiasConversion to sinus rhythm occurred w/in 2 h in 52%, 61%, and 94% of pts on placebo, flecainide and diltiazem/ propranolol, respectively (p<0.001)The conversion time was shorter after diltiazem/ propranolol (32±22 min) than after placebo (77±42 min, p<0.001) or flecainide (74± 37 min, p<0.001).26 pts discharged on diltiazem/ propranolol and 5 on flecainide. During 17±12 mo f/u, treatment successful in 81% of diltiazem/ propranolol pts and in 80% of flecainide pts (all the arrhythmic episodes were interrupted out-of-hospital w/in 2 h). In remaining pts, a failure occurred during ≥1 episodes because of drug ineffectiveness or drug unavailability.During f/u, the percentage of pts calling for emergency room assistance was significantly reduced as compared to the y before enrollment (9% vs. 100%, p<0.0001).Four pts (1 placebo, 1 diltiazem/ propranolol, and 2 flecainide) had hypotension and four (3 diltiazem/ propranolol and 1 flecainide) a sinus rate <50 bpm following SVT interruptionN/AN/AUse of these agents is efficacious in acute therapy, both w/ in-hospital and outpt therapy. However, only 4/5 pts discharged on flecainide. Complications not trivial and all pts pre-tested w/ EP study. Tendera M2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlbmRlcmE8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlbmRlcmE8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (37)11431663 Comparison of dofetilide to propafenone and placebo in the prevention of PSVT122Dofetilide (n=40)Propafenone (n=41)Placebo (n=41)18-75 y w/ ≥1 episode of PSVT w/in 6 wk documented by ECGPulmonary disease, myasthenia gravis, BBB, resting bradycardia (<50 bpm), AV block, prolonged QTc, MI, unstable angina, recent sudden death, hematologic /hepatic/renal diseaseAfter 6 mo of treatment, pts taking dofetilide, propafenone, and placebo had a 50%, 54%, and 6% probability, respectively, of remaining free of episodes of PSVT (p<.001 for both dofetilide and propafenone vs. placebo).The hazard ratio for dofetilide vs. placebo was 0.33 (95% CI: 0.18-0.61), and the hazard ratio for propafenone vs. placebo was 0.27 (95% CI: 0.14-0.51).Of 40 pts treated w/ dofetilide and propafenone, 23 (58%) and 25 (61%) had no recurring PSVT, compared w/ 16 (39%) in placebo group.19 of 40 pts (48%) treated w/ dofetilide and 21 of 41 (51%) treated w/ propafenone reported no adverse events. No significant differences were noted between 3 groups in incidence of treatment-related adverse events or all-cause adverse events (p=0.73 and p=0.74, respectively).N/AN/ADofetilide is at least as safe and effective as propafenone as an alternative therapeutic option for the treatment of pts w/ PSVT.Limited in that PSVTs not specified.Catheter Therapy (including cyroablation vs. RFA studies)Langberg JJ1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhbmdiZXJnPC9BdXRob3I+PFllYXI+MTk5MzwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhbmdiZXJnPC9BdXRob3I+PFllYXI+MTk5MzwvWWVhcj48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ADDIN EN.CITE.DATA (116)8491010Slow vs. fast path ablation for AVNRT?50Anterior (n=22)Up to 1 h or 10 RF applications before alternative techniquePosterior (n=28)Up to 1 h or 10 RF applications before alternative technique ?AVNRT None statedPrimary success rates, anterior vs. posterior(55% vs. 68%, p=NS)All pts who failed initial approach were successfully treated by alternative technique w/o developing high-grade AV blockOne pt w/ RBBB during an anterior lesionOne pt w/ complete AV block complete during posterior lesion?N/AN/APosterior (slow path) approach to RF modification of AV node is as effective as the anterior (fast path) approach, and both techniques associated w/ a low risk of complications.Limiting to 1 h or 10 attempts may underestimate success rates.Kalbfleisch SJ1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5NDwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5NDwvWWVh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ADDIN EN.CITE.DATA (117)8113557Comparison of anatomic vs. EGM mapping for AVNRT ablation (slow path)50Anatomic (n=25)sequential RF energy applications (up to 12) delivered along tricuspid annulus from level of the coronary sinus ostium to His bundle EGM mapping (n= 25)Target sites along posteromedial tricuspid annulus near coronary sinus ostium AVNRT?None statedAnatomic vs. mapping:Effective in 84 vs. 100% (p=0.1)4 w/ an ineffective anatomic approach had a successful outcome w/ mapping approachN/AITT analysisMapping vs. anatomic: Time required for ablation: (28±21 vs. 31±31 min, p=0.7) Duration of fluoroscopy: (27±20 vs. 27±18 min, p=0.9) Mean number of RF applications:(6.3±3.9 vs. 7.2±8.0, p=0.6)N/AThe anatomic and mapping approaches for ablation of the slow AV nodal pathway are comparable in efficacy and duration. Generalizability limited, and applicable only to technique described (e.g., authors cite not applicable for expanded anatomic approach or an EGM mapping approach that required the presence of a slow pathway potential).Small sample; probability of detecting a 20% difference in efficacy between two techniques only 0.67.Kopelman HA2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktvcGVsbWFuPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktvcGVsbWFuPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE.DATA (118)12633642Efficiency of conventional fluoroscopic and electroanatomic mapping (CARTO) in guiding catheter ablation of AVNRT?20Electroanatomic mapping(n=10)Fluoroscopic mapping (n=10)?AVNRT?None statedElectroanatomic vs. fluoroscopy:Fluoroscopic duration:12.6±6.8 vs. 35.9±18.3 min, p<0.001Fluoroscopic exposure (0.7±0.5 vs. 9.6±5.0 min; p<0.001Total procedure time:83.6±23.6 vs. 114±19.3 min, p=0.008 Total fluoroscopic exposure:4.2±1.4 vs. 15.9±-6.4 min, p<0.001Number of RF applications:2.7±1.6 vs. 5±2.8, p=0.018,Duration of RF:165.3±181.6 vs. 341±177.7 sec, p=0.013Total energy delivery:24.3±3.1 vs. 28.7±4.5 watts, p=0.042No acute or long-term 8.9±2.2 mo) complications or arrhythmia recurrence in either groupN/AN/AElectroanatomic mappingoffers significantly shorter procedure and fluoroscopy times, improving the efficiency of the procedure and reducing X-ray exposure.Small sample size, curious lack of side effects.Cost higher w/ electroanatomical mapping catheter, but likelyoffset by potential for improved efficiency, ptthroughput and X-ray exposure from reductions in procedure and fluoroscopy times.Kimman GP2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpbW1hbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpbW1hbjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (119)15589641CA vs. RFA?63?CA (n=30)RFA (n=33)?AVNRT?None statedProcedural success achieved in 91% RFA and 93% CA N/AMedian number of CA applications lower than RFA (p<0.005)Both fluoroscopy and procedural times were comparableN/ACA useful for treatment of tachyarrhythmias near the compact AV node.Questionable whether lack of junctional rhythm is seen w/ CA makes this approach safer than RFA, as authors remark.Zrenner B2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlpyZW5uZXI8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlpyZW5uZXI8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (120)15589640CA vs. RFA for AVNRT200CA (n=100)RFA (n=100)AVNRTN/ACumulative incidence of primary endpoint (a combination of procedural failure, permanent complete AV block and AVNRT recurrence) higher in the CA group, p=0.03Transient AV block was encountered in18% pts in the CA group and in 8% in RF group (p<0.04) 21 episodes of transient AV block occurring during cryomapping (n = 4) or CA (n = 17) and 8 episodes during RF applications. The duration of transient AV block ranged from 2-420 s in CA group and from 2-180 s in RF groupProcedural success defined as elimination of slow pathway or noninducibility of AVNRTCA vs. RFA97% vs. 98%N/AEarly pilot study (first prospective randomized investigation comparingCA w/ RFA of AVNRT) showing CA associated w/ a comparable acute success rate but a higher recurrence rate as compared w/ RFA in pts w/ AVNRT.Kardos A2007 ADDIN REFMGR.CITE <Refman><Cite><Author>Kardos</Author><Year>2007</Year><RecNum>127</RecNum><IDText>Ice mapping during tachycardia in close proximity to the AV node is safe and offers advantages for transcatheter ablation procedures</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>127</Ref_ID><Title_Primary>Ice mapping during tachycardia in close proximity to the AV node is safe and offers advantages for transcatheter ablation procedures</Title_Primary><Authors_Primary>Kardos,A.</Authors_Primary><Authors_Primary>Paprika,D.</Authors_Primary><Authors_Primary>Shalganov,T.</Authors_Primary><Authors_Primary>Vatasescu,R.</Authors_Primary><Authors_Primary>Foldesi,C.</Authors_Primary><Authors_Primary>Kornyei,L.</Authors_Primary><Authors_Primary>Szili-Torok,T.</Authors_Primary><Date_Primary>2007/12</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>Cryosurgery</Keywords><Keywords>diagnosis</Keywords><Keywords>Female</Keywords><Keywords>Fluoroscopy</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>587</Start_Page><End_Page>591</End_Page><Periodical>Acta Cardiol</Periodical><Volume>62</Volume><Issue>6</Issue><ISSN_ISBN>0001-5385</ISSN_ISBN><Address>Gottsegen Gyorgy Hungarian Institute of Cardiology, Budapest, Hungary</Address><Web_URL>PM:18214124</Web_URL><ZZ_JournalFull><f name="System">Acta cardiologica</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Acta Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(121)18214124Test the feasibility of cryomapping during AVNRT and AVRTNote: ablation performed only if cryomapping terminated the tachycardia w/o prolongation of AV conduction30AVNRT n=17AVRTn=13 Randomized after dx of AVRT or AVNRT made9 APS in CA, 4 in RF?CA (n=13 )RFA (n=17)AVNRT or AVRT w/ anteroseptal pathwayAVRT w/ a posteroseptal, left-sided, or right free wall APCA vs. RFAOverall acute success rate:85 vs. 82.4%, p=0.43CA: in one pt, ablation not attempted because of AV prolongationRFA: two pts w/ temporary second-degree AV block CA vs. RFALong-term success rate (12 mo f/u) similar between the two groupsFluoroscopy and the procedure time similar (p=0.37 and p=0.14, respectively). Mean number of applications: 2 (1-6) vs. 7 (1-41), p=0.002N/AFirst study to assess ICE mapping guided ablation in a prospective randomized method. Cryomapping a feasible method to determine exact location of APs and of slow pathway during tachycardia.Cryomapping performed during tachycardia causes less ablation lesions w/o increasing procedure and fluoroscopy times.Pediatric pts eligible and pts in CA group younger (median age 20 vs. 44). No control, and arguably 2 groups not comparable because RF not safe during tachycardia when substrate located near AV node. LocaLisa system used in CA and RF groups, thus improving performance c/w “conventional” RFA. CRYANO Study 2010 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlaXNlbmhvZmVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlaXNlbmhvZmVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN EN.CITE.DATA (122)21098435 CA vs. RFA for AVNRT509?CA (n=251)?RFA (n=258)?AVNRTPrior AVNRT ablation CHD, prior pacemaker implantation, pregnancy, and inability to follow study protocolImmediate ablation failure, permanent AV block, and AVNRT recurrence during a 6-mo f/u CA vs. RFA12.6% vs. 6.3%, p=0.018)Immediate ablation success: 96.8% vs. 98.4%, p=NSPermanent AV block: 0% vs. 0.4%, p=NSAVNRT recurrence:9.4% vs. 4.4%; P=0.029N/A (AV block in primary endpoint)CA vs. RFA.Procedure duration(138±54 vs. 123±48 min, p=0.0012) Device problems:13 vs. 2 pts, p=0.033) Pain perception lower in the cryoablation group. p<0.001N/ACA for AVNRT is as effective as RFA over short term but associated w/ higher recurrence rate at 6-mo f/u. Risk of permanent AV block does not differ significantly between CA and RFA. Potential benefits of CA relative to ablation safety and pain perception offset by longer procedure times, more device problems, and a high recurrence rate.Rodriguez-Entem FJ2013 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvZHJpZ3Vlei1FbnRlbTwvQXV0aG9yPjxZZWFyPjIwMTM8
L1llYXI+PFJlY051bT4xMzE8L1JlY051bT48SURUZXh0PkNyeW9hYmxhdGlvbiB2ZXJzdXMgcmFk
aW9mcmVxdWVuY3kgYWJsYXRpb24gZm9yIHRoZSB0cmVhdG1lbnQgb2YgYXRyaW92ZW50cmljdWxh
ciBub2RhbCByZWVudHJhbnQgdGFjaHljYXJkaWE6IHJlc3VsdHMgb2YgYSBwcm9zcGVjdGl2ZSBy
YW5kb21pemVkIHN0dWR5PC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBl
PkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+MTMxPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+Q3J5
b2FibGF0aW9uIHZlcnN1cyByYWRpb2ZyZXF1ZW5jeSBhYmxhdGlvbiBmb3IgdGhlIHRyZWF0bWVu
dCBvZiBhdHJpb3ZlbnRyaWN1bGFyIG5vZGFsIHJlZW50cmFudCB0YWNoeWNhcmRpYTogcmVzdWx0
cyBvZiBhIHByb3NwZWN0aXZlIHJhbmRvbWl6ZWQgc3R1ZHk8L1RpdGxlX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5Sb2RyaWd1ZXotRW50ZW0sRi5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+RXhwb3NpdG8sVi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkdv
bnphbGV6LUVucmlxdWV6LFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5PbGFs
bGEtQW50b2xpbixKLkouPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEzLzE8L0Rh
dGVfUHJpbWFyeT48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3
b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGkt
U3F1YXJlIERpc3RyaWJ1dGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5Dcnlvc3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwv
S2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdv
cmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5Qb3N0b3BlcmF0aXZlIENvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJyZW5j
ZTwvS2V5d29yZHM+PEtleXdvcmRzPlNhZmV0eTwvS2V5d29yZHM+PEtleXdvcmRzPlNwYWluPC9L
ZXl3b3Jkcz48S2V5d29yZHM+U3RhdGlzdGljcyxOb25wYXJhbWV0cmljPC9LZXl3b3Jkcz48S2V5
d29yZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlN1cnZpdmFsIEFuYWx5c2lzPC9LZXl3
b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRp
YSxBdHJpb3ZlbnRyaWN1bGFyIE5vZGFsIFJlZW50cnk8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBp
biBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjQxPC9TdGFydF9QYWdlPjxFbmRfUGFnZT40NTwv
RW5kX1BhZ2U+PFBlcmlvZGljYWw+SiBJbnRlcnYuQ2FyZC5FbGVjdHJvcGh5c2lvbC48L1Blcmlv
ZGljYWw+PFZvbHVtZT4zNjwvVm9sdW1lPjxJc3N1ZT4xPC9Jc3N1ZT48SVNTTl9JU0JOPjE1NzIt
ODU5NTwvSVNTTl9JU0JOPjxNaXNjXzM+MTAuMTAwNy9zMTA4NDAtMDEyLTk3MzItejwvTWlzY18z
PjxBZGRyZXNzPlVuaWRhZCBkZSBBcnJpdG1pYXMsIFNlcnZpY2lvIGRlIENhcmRpb2xvZ2lhLCBI
VSBNYXJxdWVzIGRlIFZhbGRlY2lsbGEsIFNhbnRhbmRlciwgU3BhaW48L0FkZHJlc3M+PFdlYl9V
Ukw+UE06MjMwODAzMjY8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+
Sm91cm5hbCBvZiBpbnRlcnZlbnRpb25hbCBjYXJkaWFjIGVsZWN0cm9waHlzaW9sb2d5IDogYW4g
aW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIGFycmh5dGhtaWFzIGFuZCBwYWNpbmc8L2Y+PC9aWl9K
b3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkogSW50ZXJ2
LkNhcmQuRWxlY3Ryb3BoeXNpb2wuPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zv
cm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvZHJpZ3Vlei1FbnRlbTwvQXV0aG9yPjxZZWFyPjIwMTM8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 EN.CITE.DATA (123)23080326Efficacy of CA vs. RFA119?CA (n=60)?RFA (n=59)?AVNRTN/AAcute procedural success achieved in 98% CA group and 59 100% in RFA groupOne pt in RFA group underwent complete AV block and pacemaker implantation CA vs. RFAOver a mean f/u period of 256.6 d, there was a significant difference in AVNRT recurrence (15 vs. 3.4%, p=0.03).N/ACA of AVNRT is a clinically effective alternative to RF ablation, w/ excellent acute success rate. Despite a slightly higher rate of recurrence during long-term f/u, CA may be considered first-line approach, especially in younger people. *Two protocols tested in same study.AAD indicates antiarrhythmic drug; AE, adverse effect; AF, atrial fibrillation; AP, accessory pathway; APS, acute procedureal success; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; BBB, bundle branch block; bid, two times per day; bpm indicates beats per min; CA, cryoablation; CAD, coronary artery disease; CHF, congestive heart failure; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CVA, cerebral vascular accident; c/w, consistent with; ECG, electrocardiogram; ED, emergency department; EGM, electrogram; EP, electrophysiological; f/u, follow up; HF, heart failure; h/o, history of; HR, heart rate; ICE, intracardiac echocardiography; ITT, intention to treat; IV, intravenous; LVEF, left ventricular ejection fraction; MI, myocardial infarction; N/A, not applicable; NS, not significant; NSR, normal sinus rhythm; NYHA, New York Heart Association; ORT, orthodromic reciprocating tachycardia; PAF, paroxysmal atrial fibrillation; PES, programmed electrical stimulation; PSVT, paroxysmal supraventricular tachycardia; pt, patient; RBBB, right bundle branch block; RCT, randomized controlled trial; RF, radiofrequency; RFA, radiofrequency ablation; sbp, systolic blood pressure; SDC, serum drug concentration; SSS, sick sinus syndrome; SVT, supraventricular tachycardia; sx, symptom; tid, three times per day; VHD, valvular heart disease; VT, ventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 10. Nonrandomized Trials, Observational Studies, and/or Registries of Atrioventricular Nodal Re-Entrant Tachycardia – Section 5 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsVagal Maneuvers/CardioversionMehta D1988PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laHRhPC9BdXRob3I+PFllYXI+MTk4ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (40)2897005 Prospective cohort study comparing 4 vagal maneuvers: right CSM, left CSM, face immersion in water, Valsalva maneuver35AVNRT (n=11)AVRT (n=24)EP study to induce SVT by PESExcluded AADs taken 72 h prior to admission (amiodarone stopped prior to 3 mo), no AADs during admissionTermination of at least 2 of 3 episodes of induced SVTVagal maneuvers terminated tachycardia in 22 (63%)pts.Valsalva maneuversin supine position in 19 pts (54%), right CSM in 6 (17%), left CSM in 2 (5%), and face immersion in 6 (17%). (p<0.001 for difference).Vagal maneuvers more effective in pts w/ AVRT than AVNRT (79% vs. 27%, p<0.01) Pts w/ AVRTterminated by a vagal maneuver were significantlyyounger (p<0.001) than those w/ AVRT who did not respond to vagal maneuver; no such age difference seen w/ AVNRTValsalva most effective vagal maneuver for terminating PSVT. Limited in that study conducted during EP study.Wen ZC1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (41)9851958Prospective cohort study133AVRT (n=85) AVNRT (n=48)EP study to induce PSVT by PESExcluded atrial flutter, AF organic heart disease or other systemic diseases involving the autonomic function (e.g., diabetes), those who could not blow into an aneroid manometer to maintain a pressure of 35 mm Hg for 20 sec, and those w/ unstable hemodynamics during tachycardia.Termination of PSVTVagal maneuvers more effective in terminating AVRT than AVNRT (53 vs. 33%, p<0.05). AVNRT: vagal maneuvers terminated tachycardia in antegrade slow pathway (14%) or in retrograde fast pathway (19%). Baroreflex sensitivity was poorer but isoproterenol sensitivity test better in pts w/ AVNRT.Vagal maneuvers effective, more so for AVRT. Limited in that study conducted during EP study.Roth A2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvdGg8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvdGg8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (50)12586276Prospective cohort study84PSVT 77%AF 23%Effectiveness of DC cardioversion in pts who did not respond promptly to vagal maneuvers that were tried first and then tried again after intravenously administered medical treatment w/ 1 of the following intraveneously administered drugs: adenosine, verapamil, digoxin, and/or procainamide. All study pts were hemodynamically compromised but did not require cardiopulmonary resuscitation.DC cardioversion resulted in successful converson to sinus rhythm in all pts after 103 electrical attempts, using 118±69 Joules. No complications; all but one pt (w/ pulmonary edema and cardiogenic shock) discharged alive w/in 7 d of hospitalization. Use of DC cardioversion to restore sinus rhythm can be safely and efficaciously applied in the prehospital setting in pts who are hemodynamically compromised but do not require cardiopulmonary resuscitation.Pharmacological TherapyRinkenberger RL1980 ADDIN REFMGR.CITE <Refman><Cite><Author>Rinkenberger</Author><Year>1980</Year><RecNum>153</RecNum><IDText>Effects of intravenous and chronic oral verapamil administration in patients with supraventricular tachyarrhythmias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>153</Ref_ID><Title_Primary>Effects of intravenous and chronic oral verapamil administration in patients with supraventricular tachyarrhythmias</Title_Primary><Authors_Primary>Rinkenberger,R.L.</Authors_Primary><Authors_Primary>Prystowsky,E.N.</Authors_Primary><Authors_Primary>Heger,J.J.</Authors_Primary><Authors_Primary>Troup,P.J.</Authors_Primary><Authors_Primary>Jackman,W.M.</Authors_Primary><Authors_Primary>Zipes,D.P.</Authors_Primary><Date_Primary>1980/11</Date_Primary><Keywords>Administration,Oral</Keywords><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>complications</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>996</Start_Page><End_Page>1010</End_Page><Periodical>Circulation</Periodical><Volume>62</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:7418184</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(124)7418184 Prospective cohort study28AVNRT (n=6)AVRT (n=6)AF/atrial flutter (15)AT(n=3)Effect of IV and oral verapamilIV verapamil terminated AVNRT in all 6 ptsOral verapamil given to 19/28 pts, 7 reported improvement in sxs after 19 mo f/u (shorter frequency and shorter duration)IV verapamil effective in acute termination, while oral verapamil has selective efficacy. Das G1988PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhczwvQXV0aG9yPjxZZWFyPjE5ODg8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhczwvQXV0aG9yPjxZZWFyPjE5ODg8L1llYXI+PFJlY051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 EN.CITE.DATA (125) HYPERLINK "" 2905710 Prospective cohort study113Pts w/ PSVT (HR >100).Efficacy and safety of esmolol. Also investigated feasibility of transferring pts from esmolol to alternate oral AADs w/o loss of therapeutic response.95 (84%) achieved therapeutic response (reduction in heart rate of 15% or more or conversion to sinus rhythm). 93% achieved therapeutic response at esmolol doses of 200 micrograms/kg/min or lower.(88%) pts successfully transferred to oral AADs.Most frequent adverse effect observed during the study was hypotension, which resolved quickly (16±14 min)Esmolol effective in HR reduction or convertion to NSR, and majority of pts successfully treated w/ esmolol can be safely and effectively transferred to oral AADs.Rankin AC1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Rankin</Author><Year>1989</Year><RecNum>25</RecNum><IDText>Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>25</Ref_ID><Title_Primary>Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias</Title_Primary><Authors_Primary>Rankin,A.C.</Authors_Primary><Authors_Primary>Oldroyd,K.G.</Authors_Primary><Authors_Primary>Chong,E.</Authors_Primary><Authors_Primary>Rae,A.P.</Authors_Primary><Authors_Primary>Cobbe,S.M.</Authors_Primary><Date_Primary>1989/9</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>diagnosis</Keywords><Keywords>diagnostic use</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>195</Start_Page><End_Page>203</End_Page><Periodical>Br.Heart J</Periodical><Volume>62</Volume><Issue>3</Issue><User_Def_5>PMC1216762</User_Def_5><ISSN_ISBN>0007-0769</ISSN_ISBN><Address>University Department of Medical Cardiology, Royal Infirmary, Glasgow</Address><Web_URL>PM:2789911</Web_URL><ZZ_JournalFull><f name="System">British heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Br.Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(43)2789911 Cohort study6494 episodes of sustained, regular tachycardia; 40 pts w/ 64 episodes of narrow complex tachycardia (9 induced at EP study)Efficacy of IV adenosineAdenosine restored sinus rhythm in 25 pts 46/48 pts) w/ “junctional tachycardia,” found to be due to AVRT or AVNRTNot specific for AVNRT (defined AVRT and AVNRT as “junctional tachycardia”Amsterdam EA1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Amsterdam</Author><Year>1991</Year><RecNum>147</RecNum><IDText>Efficacy of cardioselective beta-adrenergic blockade with intravenously administered metoprolol in the treatment of supraventricular tachyarrhythmias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>147</Ref_ID><Title_Primary>Efficacy of cardioselective beta-adrenergic blockade with intravenously administered metoprolol in the treatment of supraventricular tachyarrhythmias</Title_Primary><Authors_Primary>Amsterdam,E.A.</Authors_Primary><Authors_Primary>Kulcyski,J.</Authors_Primary><Authors_Primary>Ridgeway,M.G.</Authors_Primary><Date_Primary>1991/8</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>chemically induced</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Hypotension</Keywords><Keywords>Infusions,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Metoprolol</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>714</Start_Page><End_Page>718</End_Page><Periodical>J Clin.Pharmacol</Periodical><Volume>31</Volume><Issue>8</Issue><ISSN_ISBN>0091-2700</ISSN_ISBN><Address>Department of Internal Medicine, University of California School of Medicine, Davis 95817</Address><Web_URL>PM:1880230</Web_URL><ZZ_JournalFull><f name="System">Journal of clinical pharmacology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Clin.Pharmacol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(126) HYPERLINK "" 1880230 Prospective cohort study16AF (n=11)Atrial flutter (n=2)PSVT (n=2)MAT (n=1) In 13 responders (81%), mean ventricular rate decreased from 134±6 to 106±7 bpm 10 min after metoprolol administration and controlled for 40-320 min w/o further therapy. Metoprolol reduced ventricular rate by >15% in 11 (69%) of 16 pts, including 9 (82%) of 11 pts w/ AF. In one w/ AF and one w/ PSVT, ventricular rate was reduced by >12%Hypotension, occurring in five pts, was the most frequent side effect but was transient and readily managed.Metoprolol was rapidly effective in controlling ventricular rate in a majority of pts w/ supraventricular tachyarrhythmias. Limited data for AVNRT.Cairns CB1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Cairns</Author><Year>1991</Year><RecNum>22</RecNum><IDText>Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>22</Ref_ID><Title_Primary>Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Cairns,C.B.</Authors_Primary><Authors_Primary>Niemann,J.T.</Authors_Primary><Date_Primary>1991/7</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>complications</Keywords><Keywords>diagnosis</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electroencephalography</Keywords><Keywords>Emergencies</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>717</Start_Page><End_Page>721</End_Page><Periodical>Ann Emerg.Med</Periodical><Volume>20</Volume><Issue>7</Issue><ISSN_ISBN>0196-0644</ISSN_ISBN><Misc_3>S0196-0644(05)80829-7</Misc_3><Address>UCLA School of Medicine, Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance 90509</Address><Web_URL>PM:2064090</Web_URL><ZZ_JournalFull><f name="System">Annals of emergency medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(44)2064090 Observational cohort23Conversion to SR16 y or older presenting to ED in an 8 mo study period w/ sustained SVT, rate >140 bpmExclusion: severe CHF, unstable angina, acute MI by ECG, hemodynamic compromise. Excluded sinus tachycardia, atrial flutter, AF, QRS >140 msAdenosine to convert SR in ED setting2 pts after adenosine identified as not having SVT (atrial flutter, VT)24 episodes of SVT in 21 pts of which 96% converted w/ adenosine (mean dose 10±6 mg)SVT recurred in 57% of episodes and other antiarrhythmic drugs then used to maintain SR. Adverse effects: 3 pts w/ chest pain, one pt w/ dyspnea but no adverse outcomeAdenosine highly effective in converted SVT but recurrences frequentMusto B1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk11c3RvPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk11c3RvPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (127)1615792 Prospective cohort study35 9 pts w/ AVNRT (Age 10-23)Recurrent PSVT documented by ECG; no h/o VT or AF, well-tolerated PSVT not induced by stress9 total pts w/ AVNRT, remainder w/ AVRTTermination of PSVT by flecainide.PSVT terminated in 6/9. Pts prescreened w/ EP study. Non-randomized study, and limited number of pts w/ AVNRT. Gambhir DS1995 ADDIN REFMGR.CITE <Refman><Cite><Author>Gambhir</Author><Year>1995</Year><RecNum>149</RecNum><IDText>Electrophysiologic effects and therapeutic efficacy of intravenous flecainide for termination of paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>149</Ref_ID><Title_Primary>Electrophysiologic effects and therapeutic efficacy of intravenous flecainide for termination of paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Gambhir,D.S.</Authors_Primary><Authors_Primary>Bhargava,M.</Authors_Primary><Authors_Primary>Arora,R.</Authors_Primary><Authors_Primary>Khalilullah,M.</Authors_Primary><Date_Primary>1995/5</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Cardiology</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>237</Start_Page><End_Page>243</End_Page><Periodical>Indian Heart J</Periodical><Volume>47</Volume><Issue>3</Issue><ISSN_ISBN>0019-4832</ISSN_ISBN><Address>Department of Cardiology, G.B. Pant Hospital, New Delhi</Address><Web_URL>PM:7558090</Web_URL><ZZ_JournalFull><f name="System">Indian heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Indian Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(128)7558090 Prospective cohort study26All pts w/ symptomatic PSVT, recurrent palpitations for 1-13 yEP study performed, IV flecainide given and then EP study repeated 20-30 min later w/ IV flecainideEffective in terminating all pts w/ AVNRT, 11/12 w/ AVRTTime to termination both similar (146±70 vs. 149±29 sec, AVNRT vs. AVRT)AVNRT reinducible in one pt w/ AVNRT, 4 pts w/ AVRT Selective depression of retrograde limbN/AIV flecainide effective and safe for acute episodes of AVNRT and AVRTOral therapy presumed to be effective given effects in preventing reinducibility.EP study efficacy.Gambhir DS1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbWJoaXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS
ZWNOdW0+MTUwPC9SZWNOdW0+PElEVGV4dD5Db21wYXJpc29uIG9mIGVsZWN0cm9waHlzaW9sb2dp
YyBlZmZlY3RzIGFuZCBlZmZpY2FjeSBvZiBzaW5nbGUtZG9zZSBpbnRyYXZlbm91cyBhbmQgbG9u
Zy10ZXJtIG9yYWwgYW1pb2Rhcm9uZSB0aGVyYXB5IGluIHBhdGllbnRzIHdpdGggQVYgbm9kYWwg
cmVlbnRyYW50IHRhY2h5Y2FyZGlhPC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJl
Zl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+MTUwPC9SZWZfSUQ+PFRpdGxlX1ByaW1h
cnk+Q29tcGFyaXNvbiBvZiBlbGVjdHJvcGh5c2lvbG9naWMgZWZmZWN0cyBhbmQgZWZmaWNhY3kg
b2Ygc2luZ2xlLWRvc2UgaW50cmF2ZW5vdXMgYW5kIGxvbmctdGVybSBvcmFsIGFtaW9kYXJvbmUg
dGhlcmFweSBpbiBwYXRpZW50cyB3aXRoIEFWIG5vZGFsIHJlZW50cmFudCB0YWNoeWNhcmRpYTwv
VGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdhbWJoaXIsRC5TLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+QmhhcmdhdmEsTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5Pk5haXIsTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkFyb3Jh
LFIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5LaGFsaWx1bGxhaCxNLjwvQXV0
aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk5Ni8zPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRz
PmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwvS2V5d29yZHM+PEtleXdvcmRzPkFkbWluaXN0
cmF0aW9uLE9yYWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRz
PkFtaW9kYXJvbmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+Ymxvb2Q8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9sb2d5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+RG9zZS1SZXNwb25zZSBSZWxhdGlvbnNoaXAsRHJ1ZzwvS2V5d29y
ZHM+PEtleXdvcmRzPkRydWcgQWRtaW5pc3RyYXRpb24gU2NoZWR1bGU8L0tleXdvcmRzPjxLZXl3
b3Jkcz5kcnVnIHRoZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJpYyBTdGltdWxhdGlv
bjwvS2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9jYXJkaW9ncmFwaHk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5FbGVjdHJvcGh5c2lvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29y
ZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5z
PC9LZXl3b3Jkcz48S2V5d29yZHM+SW5mdXNpb25zLEludHJhdmVub3VzPC9LZXl3b3Jkcz48S2V5
d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5
d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRob2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8
L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxBdHJpb3ZlbnRyaWN1bGFyIE5vZGFsIFJl
ZW50cnk8L0tleXdvcmRzPjxLZXl3b3Jkcz50aGVyYXBldXRpYyB1c2U8L0tleXdvcmRzPjxLZXl3
b3Jkcz50aGVyYXB5PC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3Rh
cnRfUGFnZT4xMzM8L1N0YXJ0X1BhZ2U+PEVuZF9QYWdlPjEzNzwvRW5kX1BhZ2U+PFBlcmlvZGlj
YWw+SW5kaWFuIEhlYXJ0IEo8L1BlcmlvZGljYWw+PFZvbHVtZT40ODwvVm9sdW1lPjxJc3N1ZT4y
PC9Jc3N1ZT48SVNTTl9JU0JOPjAwMTktNDgzMjwvSVNTTl9JU0JOPjxBZGRyZXNzPkRlcGFydG1l
bnQgb2YgQ2FyZGlvbG9neSwgR0IgUGFudCBIb3NwaXRhbCwgTmV3IERlbGhpPC9BZGRyZXNzPjxX
ZWJfVVJMPlBNOjg2ODI1NTI8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3Rl
bSI+SW5kaWFuIGhlYXJ0IGpvdXJuYWw8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0
ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkluZGlhbiBIZWFydCBKPC9mPjwvWlpfSm91cm5hbFN0
ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1Jl
Zm1hbj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbWJoaXI8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (54)8682552 Prospective cohort study9All pts w/ symptomatic AVNRT, recurrent palpitations for 2-12 y EP study performed, IV amiodarone then oral therapy subsequently EP study repeated 1.5-3 mo laterNo pts reported sxs of tachycardia during mean f/u of 65 d on oral amiodaroneIV amiodarone terminated AVNRT in 7/9 pts (retrograde FP in 4/7 and anterograde SP in 3/7)Not inducible on PES after oral therapy, largely to due to prolonging refractoriness in atrium and ventricle, and depressing conduction through FPN/ASmall series of pts, but all w/ AVNRTOral therapy w/ amiodarone is effective in suppressing AVNRT.IV amiodarone is effective in acute therapy.EP study efficacy.Glatter KA1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdsYXR0ZXI8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdsYXR0ZXI8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (129) HYPERLINK "" 10051297 Retrospective cohort study229PSVT during EP studyAVRT (n=59)Typical AVNRT (n=82)Artypical AVNRT (n=13)PJRT (n=12)AT (n=53)IST (n=10)Determining the mechanism of PSVT w/ adenosine responseAdenosine of limited value in determining mechanism of PSVT100% of pts w/ AVNRT, AVRT, atypical AVNRT, and PJRT terminated w/ adenosineN/AAblationJackman WM1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (53)1620170 Prospective observational cohort80Symptomatic AVNRT undergoing RFA of slow-pathwaySuccessful ablation w/ intact AV nodal conduction, guided by atrial slow-path potentialsRFA abolished or modified slow-pathway conduction in 78/80 pts w/o affecting normal AVN conduction. Mean (±SD) f/u of 15.5 mo w/o recurrence. Early report of success of RFA of slow-path conduction guided by atrial slow-path potentials—led to slow-pathway ablation being preferred method. Provided evidence that atrial insertions of fast and slow path are anatomically distinct.Kay GN1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Kay</Author><Year>1992</Year><RecNum>157</RecNum><IDText>Selective radiofrequency ablation of the slow pathway for the treatment of atrioventricular nodal reentrant tachycardia. Evidence for involvement of perinodal myocardium within the reentrant circuit</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>157</Ref_ID><Title_Primary>Selective radiofrequency ablation of the slow pathway for the treatment of atrioventricular nodal reentrant tachycardia. Evidence for involvement of perinodal myocardium within the reentrant circuit</Title_Primary><Authors_Primary>Kay,G.N.</Authors_Primary><Authors_Primary>Epstein,A.E.</Authors_Primary><Authors_Primary>Dailey,S.M.</Authors_Primary><Authors_Primary>Plumb,V.J.</Authors_Primary><Date_Primary>1992/5</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Cardiac Catheterization</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Radio Waves</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>1675</Start_Page><End_Page>1688</End_Page><Periodical>Circulation</Periodical><Volume>85</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University of Alabama, Birmingham 35294</Address><Web_URL>PM:1572026</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(130)1572026 Prospective observational cohort34 Slow pathway ablation (n=30)Fast pathway ablation (n=4)Antegrade conduction over the fast pathway remained intact in all 30 pts after successful selective slow pathway ablationThere was no statistically significant change in the atrio-His interval (68.5±21.8 msec before and 69.6±23.9 msec after ablation) or AV Wenckebach rate (167±27 beats per min before and 178±50 beats per min after ablation) after slow path ablation 3 complications in two pts, including an episode of pulmonary edema and the development of spontaneous AV Wenckebach block during sleep in one pt after slow pathway ablation and the late development of complete AV block in another pt after fast pathway ablation. Over a mean f/u period of 322±73 d, AVNRT recurred in three pts, all of whom were successfully treated w/ a second ablation.Early report suggesting benefits of slow pathway ablation over fast pathway ablation. Bogun F1996 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvZ3VuPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvZ3VuPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (131)8837581 Prospective observational cohort7 w/ noninducible AVNRT compared w/ 34 w/ inducible AVNRTSpontaneous but noninducible AVNRT (w/ evidence of dual AV nodal physiology at EP study) All evidence of dual AV node pathways was eliminated in six pts, and dual AV node physiology remained present in one pt. During a mean f/u period of 15±10 mo (range 8 to 27), no pt had a recurrence of symptomatic tachycardia (success rate 95%).N/ASlow pathway ablation may be clinically useful in pts w/ documented but noninducible PSVT who have evidence of dual AV node pathwaysFirst recommendation that slow pathway ablation be indicated in pts w/ spontaneous PSVT w/ dual AV node physiology but noninducible PSVT in EP study. Small sample size.D’Este D2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkQmYXBvcztFc3RlPC9BdXRob3I+PFllYXI+MjAwNzwvWWVh
cj48UmVjTnVtPjE1NTwvUmVjTnVtPjxJRFRleHQ+TG9uZy10ZXJtIG91dGNvbWUgb2YgcGF0aWVu
dHMgd2l0aCBhdHJpb3ZlbnRyaWN1bGFyIG5vZGUgcmVlbnRyYW50IHRhY2h5Y2FyZGlhPC9JRFRl
eHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxS
ZWZfSUQ+MTU1PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+TG9uZy10ZXJtIG91dGNvbWUgb2YgcGF0
aWVudHMgd2l0aCBhdHJpb3ZlbnRyaWN1bGFyIG5vZGUgcmVlbnRyYW50IHRhY2h5Y2FyZGlhPC9U
aXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RCZhcG9zO0VzdGUsRC48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PlpvcHBvLEYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5CZXJ0YWdsaWEsRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Plpl
cmJvLEYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5QaWNjaW9sbyxBLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2NhcmFiZW8sVi48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5PlBhc2NvdHRvLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5QYXNjb3R0byxQLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwNy8y
LzE0PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jk
cz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPmFkdmVyc2UgZWZmZWN0czwvS2V5d29yZHM+PEtl
eXdvcmRzPkFnZSBGYWN0b3JzPC9LZXl3b3Jkcz48S2V5d29yZHM+QW5hbHlzaXMgb2YgVmFyaWFu
Y2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaW92ZW50cmljdWxhciBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlv
bG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVyIEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5
d29yZHM+Q29ob3J0IFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5FY2hvY2FyZGlvZ3JhcGh5LFRyYW5zZXNvcGhhZ2VhbDwvS2V5d29y
ZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVz
PC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXRhbHk8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29y
ZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+bW9ydGFsaXR5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Qcm9iYWJpbGl0
eTwvS2V5d29yZHM+PEtleXdvcmRzPlByb3NwZWN0aXZlIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzayBBc3Nlc3NtZW50PC9LZXl3
b3Jkcz48S2V5d29yZHM+U2V2ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwvS2V5d29yZHM+PEtleXdv
cmRzPlNleCBGYWN0b3JzPC9LZXl3b3Jkcz48S2V5d29yZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtl
eXdvcmRzPlN1cnZpdmFsIFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwvS2V5
d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLEF0cmlvdmVudHJpY3VsYXIgTm9kYWwgUmVlbnRy
eTwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PEtleXdvcmRz
PnRoZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPnVsdHJhc29ub2dyYXBo
eTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+MzUw
PC9TdGFydF9QYWdlPjxFbmRfUGFnZT4zNTM8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkludC5KIENh
cmRpb2w8L1BlcmlvZGljYWw+PFZvbHVtZT4xMTU8L1ZvbHVtZT48SXNzdWU+MzwvSXNzdWU+PElT
U05fSVNCTj4xODc0LTE3NTQ8L0lTU05fSVNCTj48TWlzY18zPlMwMTY3LTUyNzMoMDYpMDA0MDct
NDsxMC4xMDE2L2ouaWpjYXJkLjIwMDYuMDQuMDM1PC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVu
dCBvZiBDYXJkaW9sb2d5LCBDaXZpYyBIb3NwaXRhbCBvZiBNaXJhbm8sIFZpYSBNYXJpdXR0byAx
NCwgMzAwMzUgTWlyYW5vIChWZW5pY2UpLCBJdGFseS4gZGFuaS5kZXN0ZUBhbGljZXBvc3RhLml0
PC9BZGRyZXNzPjxXZWJfVVJMPlBNOjE2ODE0NDE2PC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48
ZiBuYW1lPSJTeXN0ZW0iPkludGVybmF0aW9uYWwgam91cm5hbCBvZiBjYXJkaW9sb2d5PC9mPjwv
WlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5JbnQu
SiBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9X
b3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkQmYXBvcztFc3RlPC9BdXRob3I+PFllYXI+MjAwNzwvWWVh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ADDIN EN.CITE.DATA (132)16814416 Prospective cohort study93Pts w/ AVNRT prospectively followed for mean 13.2 y, compare outcomes of ablation (n=18) vs. AADs (n=24) vs. no therapy (n=38)AADs: flecainide, propafenone, verapamil, sotalol, atenolol, diltiazemAt f/u, asymptomatic for 3 y:Ablation: 100%AADs: 60.8%No therapy: 44.7%Untreated pts who became asymptomatic had a shorter duration of sxs before enrolment (3.7±1.5 vs. 7.1±3.6 y, p<0.05) and a shorter mean length of tachycardia episodes (3.8±2.4 vs. 42.6±17.8 min, p<0.02) than pts from same group who remained symptomatic3 pts died, 10 lost to f/uDuring a long-term f/u a considerable number of untreated pts w/ AVNRT become asymptomatic.Suggests that pts w/ infrequent and minor sxs may be able to be treated conservatively (i.e., no ablation or AADs.Study directly evaluates AVNRT and suggests efficacy of ablation over AADs.Limitations that the results are sx based.Spector P2009 ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)19699343 Systematic review and meta-analysis to evaluate the safety and efficacy of RFA of AVNRT, AP-mediated, and atrial flutter.For AVNRT and AP-mediated: 39 primary studies w/ 49 treatment arms in 7,693 ptsPrevious reviews or meta-analyses; animal or in vitro studies; subjects aged <18 y or mixed populations of which >15% were pediatric pts; f/u of <7 d; not studies of RFA; alternative energy sources used for ablation; AV junction ablation w/ pacemaker implantation; <40 pts per arrhythmia or ablation technique; published only in abstract form; published before 1990; and published in languages other than English, Spanish, French, Italian, German, and Portuguese.SVT (AVNRT and AP-mediated)Single- and multiple-procedure success, arrhythmia recurrence, repeat ablation, adverse events, and death Single-procedure success: 93.2% (95% CI: 90.8-95.5%). Multiple-procedure success: 94.6%(95% CI: 92.4- 96.9).Post-ablation arrhythmia: 5.6% (95% CI: 4.1-7.2%). Repeat ablation: 6.5% (95% C:I 4.7-8.3%)All-cause mortality: 0.1%Adverse events: 2.9% First meta-analysis of RFA for AVNRT, AVRT (AP-mediated). Demonstrates high efficacy rates and low rates of complications.Outcomes (Registry Data)Hindricks G1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhpbmRyaWNrczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhpbmRyaWNrczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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=
ADDIN EN.CITE.DATA (57)8131762 Prospective cohort4398AT/atrial flutter (n=141, 3.2%)AVJ (n=900, 20.5%)AVNRT (n=815, 18.5%)AVRT: (n = 2222, 50.5%)VT (n=320, 7.3%).Incidence of complicationsComplications occurred in 223 pts (5.1%) overallAT/atrial flutter: 5.0%AVJ: 3.2%AVNRT: 8.0%AVRT: 4.4%VT: 7.5%Complications more in AVNRT RFA compared to AVJ or AP ablation (p<0.001) Complications more in VT compared to AVJ (p<0.002) or AP (p<0.02)Early report showing high incidence of complications after AVNRT ablation.Hindricks G1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Hindricks</Author><Year>1996</Year><RecNum>161</RecNum><IDText>Incidence of complete atrioventricular block following attempted radiofrequency catheter modification of the atrioventricular node in 880 patients. Results of the Multicenter European Radiofrequency Survey (MERFS) The Working Group on Arrhythmias of the European Society of Cardiology</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>161</Ref_ID><Title_Primary>Incidence of complete atrioventricular block following attempted radiofrequency catheter modification of the atrioventricular node in 880 patients. Results of the Multicenter European Radiofrequency Survey (MERFS) The Working Group on Arrhythmias of the European Society of Cardiology</Title_Primary><Authors_Primary>Hindricks,G.</Authors_Primary><Date_Primary>1996/1</Date_Primary><Keywords>adverse effects</Keywords><Keywords>analysis</Keywords><Keywords>Atrioventricular Block</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Cross-Sectional Studies</Keywords><Keywords>epidemiology</Keywords><Keywords>Europe</Keywords><Keywords>Heart Block</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Patients</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>82</Start_Page><End_Page>88</End_Page><Periodical>Eur Heart J</Periodical><Volume>17</Volume><Issue>1</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Web_URL>PM:8682135</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(58)8682135 Prospective cohort4463AVNRT (n=880)Incidence of AV blockAV block (4/ 880, 4.7%). AV block higher in fast pathway ablation (19/361, 5.3%, p<0.05) 6.3% in centers w/ limited experience in RFA (≤30 pts treated, p<0.05), and higher in these low-volume centers for both slow and fast pathway ablation (p<0.05)Early report showing 5% incidence of AV block after RFA for AVNRT, and higher w/ fast pathway ablation.Calkins H1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (59)9892593 Prospective cohort1050(previously enrolled in RFA clinical trial)RFA of AVNRT, AP, or AVJAVNRT (n=373)AP (n=500)AVJ (n=121)Efficacy and safety of RFA w/ long-term f/u.Overall success:95%Overall recurrence6%Success:AVNRT: 97%AP: 93%AVJ: 100%Recurrence:AVNRT: 5%AP: 8%AVJ: 2%Predictors of success:-AVNRTOR: 3.94 (95% CI: 1.93-8.04; p=0.0002)-Left free wall APOR: 3.09 (95% CI: 1.46-6.53; p=0.0003)-Experience of ablation center (>39 pts)OR: 2.39 (95% CI: 1.21-4.71; p=0.012)Joint predictors of mortality:-EF (p=0.003)-SHD (p=0.016)-AVJ ablation (p=0.048)Shows RFA is a favorable option w/ low risk of complications and recurrence, and identifies pts who are at risk. Per-protocol analysisScheinman MM2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Scheinman</Author><Year>2000</Year><RecNum>162</RecNum><IDText>The 1998 NASPE prospective catheter ablation registry</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>162</Ref_ID><Title_Primary>The 1998 NASPE prospective catheter ablation registry</Title_Primary><Authors_Primary>Scheinman,M.M.</Authors_Primary><Authors_Primary>Huang,S.</Authors_Primary><Date_Primary>2000/6</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Arteries</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiomyopathies</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Disease</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Hospitals,Teaching</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Recurrence</Keywords><Keywords>Registries</Keywords><Keywords>statistics & numerical data</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Ventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>1020</Start_Page><End_Page>1028</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>23</Volume><Issue>6</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>Department of Medicine, University of California, San Francisco, USA. scheinman@ep4.ucsf.edu</Address><Web_URL>PM:10879389</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(61)10879389 Prospective cohort study(NASPE registry)3,357Ablation of AVNRT, AP, AVJ, atrial flutter, AT, IST, VT, idiopathic VTAVNRT (n=1,197 [35.6%)AVJ (n=646)AP (n=654)AT (n=216)Atrial flutter (n=447)IST (n=40)Efficacy and safety of RFA w/ long-term f/u.AVNRTSuccess: 96.1%Complications: 2%AVJ: Success: 96%Complications: 25 ptsRecurrence: 3.5%AP:Success: 94-96%Complications: 31 pts totalRecurrence: 4.6%AT:Success: 51-79%Complications: 5 totalRecurrence: 15.2%Atrial flutter:Success: 86%Complications: 12 ptsRecurrence: 14.7%IST:Success: 71%Complications: 2 ptsRecurrence: 10%Large series reporting success of RFA, and stratification by age group confirms safety and efficacy in elderly pts, as well as by type of facility (teaching vs. community).Special Ablation TechniquesFriedman PL2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZyaWVkbWFuPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48
UmVjTnVtPjE2NDwvUmVjTnVtPjxJRFRleHQ+Q2F0aGV0ZXIgY3J5b2FibGF0aW9uIG9mIHN1cHJh
dmVudHJpY3VsYXIgdGFjaHljYXJkaWE6IHJlc3VsdHMgb2YgdGhlIG11bHRpY2VudGVyIHByb3Nw
ZWN0aXZlICZxdW90O2Zyb3N0eSZxdW90OyB0cmlhbDwvSURUZXh0PjxNREwgUmVmX1R5cGU9Ikpv
dXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjE2NDwvUmVmX0lEPjxU
aXRsZV9QcmltYXJ5PkNhdGhldGVyIGNyeW9hYmxhdGlvbiBvZiBzdXByYXZlbnRyaWN1bGFyIHRh
Y2h5Y2FyZGlhOiByZXN1bHRzIG9mIHRoZSBtdWx0aWNlbnRlciBwcm9zcGVjdGl2ZSAmcXVvdDtm
cm9zdHkmcXVvdDsgdHJpYWw8L1RpdGxlX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5GcmllZG1h
bixQLkwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5EdWJ1YyxNLjwvQXV0aG9y
c19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+R3JlZW4sTS5TLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+SmFja21hbixXLk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5LZWFuZSxELlQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5NYXJpbmNo
YWssUi5BLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TmF6YXJpLEouPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5QYWNrZXIsRC5MLjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+U2thbmVzLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5TdGVpbmJlcmcsSi5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U3Rl
dmVuc29uLFcuRy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRjaG91LFAuSi48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PldpbGJlcixELkouPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Xb3JsZXksUy5KLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRl
X1ByaW1hcnk+MjAwNC83PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkJvc3Rvbjwv
S2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVyIEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+
Q2hpLVNxdWFyZSBEaXN0cmlidXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5Dcnlvc3VyZ2VyeTwv
S2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5
d29yZHM+PEtleXdvcmRzPkxvZ2lzdGljIE1vZGVsczwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8
L0tleXdvcmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGll
bnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UG9zdG9wZXJhdGl2ZSBDb21wbGljYXRpb25zPC9LZXl3
b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPlJp
c2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5TYWZldHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5
PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNo
eWNhcmRpYSxTdXByYXZlbnRyaWN1bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+VHJlYXRtZW50IE91
dGNvbWU8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdl
PjEyOTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTM4PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5IZWFy
dCBSaHl0aG08L1BlcmlvZGljYWw+PFZvbHVtZT4xPC9Wb2x1bWU+PElzc3VlPjI8L0lzc3VlPjxJ
U1NOX0lTQk4+MTU0Ny01MjcxPC9JU1NOX0lTQk4+PE1pc2NfMz5TMTU0NzUyNzEwNDAwMTA4MDsx
MC4xMDE2L2ouaHJ0aG0uMjAwNC4wMi4wMjI8L01pc2NfMz48QWRkcmVzcz5DYXJkaW92YXNjdWxh
ciBEaXZpc2lvbiwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgQnJpZ2hhbSBhbmQgV29tZW4mYXBv
cztzIEhvc3BpdGFsLCBCb3N0b24sIE1hc3NhY2h1c2V0dHMsIFVTQTwvQWRkcmVzcz48V2ViX1VS
TD5QTToxNTg1MTE0MzwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5I
ZWFydCByaHl0aG0gOiB0aGUgb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSGVhcnQgUmh5dGhtIFNv
Y2lldHk8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJT
eXN0ZW0iPkhlYXJ0IFJoeXRobTwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3Jt
SUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+AG==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZyaWVkbWFuPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (133)15851143 Multicenter prospective study157(166 initially enrolled)AVNRT (n=101)AVRT (n=44)AF (n=12)Efficacy of cryomapping/ablation Acute success overall 83%Success in AVNRT 91%, 69% AVRT and 67% AVJ (p<0.001)Per-protocol:Success in AVNRT 93%, 77% for AVRT and 67% for AVJLong-term success after 6 mo 91% overall, 94% for AVNRTCryomapping successfully identified ablation targets in 64% of pts, effects completely reversible w/in minutes in 94% of attemptsAcute success lower for CA compared to studies in RFA, but w/ no difference in long-term outcomes or arrhythmia recurrence.Later reports show improved success.de Sisti A2011 ADDIN REFMGR.CITE <Refman><Cite><Author>de Sisti</Author><Year>2012</Year><RecNum>163</RecNum><IDText>Cryoablation of atrioventricular nodal reentrant tachycardia: a clinical review</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>163</Ref_ID><Title_Primary>Cryoablation of atrioventricular nodal reentrant tachycardia: a clinical review</Title_Primary><Authors_Primary>de Sisti,A.</Authors_Primary><Authors_Primary>Tonet,J.</Authors_Primary><Date_Primary>2012/2</Date_Primary><Keywords>Atrioventricular Block</Keywords><Keywords>Cardiology</Keywords><Keywords>Cryosurgery</Keywords><Keywords>Humans</Keywords><Keywords>mortality</Keywords><Keywords>Prevalence</Keywords><Keywords>Risk Assessment</Keywords><Keywords>Risk Factors</Keywords><Keywords>surgery</Keywords><Keywords>Survival Analysis</Keywords><Keywords>Survival Rate</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>utilization</Keywords><Reprint>Not in File</Reprint><Start_Page>233</Start_Page><End_Page>240</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>35</Volume><Issue>2</Issue><ISSN_ISBN>1540-8159</ISSN_ISBN><Misc_3>10.1111/j.1540-8159.2011.03244.x</Misc_3><Address>Rhythmology Unit, Cardiology Institute, Pitie-Salpetriere Hospital, Paris, France</Address><Web_URL>PM:22017562</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(134)22017562 Systematic review22 studies w/ 2,654 ptsCryoablation for AVNRT compared to RFAOverall success 95% (95% CI: 85-99%), but recurrence rate 11% (95% CI: 2-20%). RFA recurrence rate reported at 3-5%. N/ACryoablation effective and safe, but lower long-term clinical efficacy compared to RFA. Hanninen M2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhbm5pbmVuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhbm5pbmVuPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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ADDIN EN.CITE.DATA (135)24016223 Systematic review and meta-analysis14 studies (5 RCTs), 5,617 pts (1990-2012). 3 studies pediatricPts w/ AVNRT treated w/ cryoablation vs. RFA (81%)AVNRT recurrence (>2 mo post procedure; acute procedural failure and AV block requiring pacingAcute failure w/ cryoablation was nonsignificantly slightly higher than w/ RFA (RR: 1.44; p=0.12).Long-term recurrence higher w/ cryoablation (RR: 3.66; p=0.0002) RFA associated w/ permanent AV block in 0.75% of pts, none w/ cryoablation (p=0.01).Although late-recurrence more common w/ cryoablation than w/ RFA, avoidance of permanent AV block is advantageous Santangeli P2014 ADDIN REFMGR.CITE <Refman><Cite><Author>Santangeli</Author><Year>2014</Year><RecNum>166</RecNum><IDText>Cryoablation versus radiofrequency ablation of atrioventricular nodal reentrant tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>166</Ref_ID><Title_Primary>Cryoablation versus radiofrequency ablation of atrioventricular nodal reentrant tachycardia</Title_Primary><Authors_Primary>Santangeli,P.</Authors_Primary><Authors_Primary>Proietti,R.</Authors_Primary><Authors_Primary>Di,Biase L.</Authors_Primary><Authors_Primary>Bai,R.</Authors_Primary><Authors_Primary>Natale,A.</Authors_Primary><Date_Primary>2014/3</Date_Primary><Keywords>analysis</Keywords><Keywords>Atrioventricular Block</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Female</Keywords><Keywords>Fluoroscopy</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>physiology</Keywords><Keywords>Recurrence</Keywords><Keywords>Risk</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>111</Start_Page><End_Page>119</End_Page><Periodical>J Interv.Card.Electrophysiol.</Periodical><Volume>39</Volume><Issue>2</Issue><ISSN_ISBN>1572-8595</ISSN_ISBN><Misc_3>10.1007/s10840-013-9842-2</Misc_3><Address>Cardiac Arrhythmia Service, Stanford University School of Medicine, 300 Pasteur Drive H 2146, Stanford, CA, 94305, USA, pasquale.santangeli@</Address><Web_URL>PM:24293174</Web_URL><ZZ_JournalFull><f name="System">Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Interv.Card.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(136)24293174 Systematic review and meta-analysis14 studies (9 observational) w/ 2,340 pts (1980-2013)Pts w/ AVNRT treated w/ CA (54%) vs. RFA (46%)Successful ablation, procedural time, fluoroscopy time, complicationsAcute success in 88% w/ RFA, vs. 83% treated w/ CA (OR: 0.72; p=0.16)RFA associated w/ shorter total procedure time (p=0.004), but slightly longer fluoroscopy time (p=0.002). Permanent AV block occurred in 0.9% RF case, none in CA cases (OR:?3.60; p=0.035). Freedom from recurrent AVNRT (10.5 mo median f/u) 97% in RF group vs. 90.9% in the CA group (OR:?0.40; p<?0.001).RF significantly reduces the risk of long-term arrhythmia recurrence compared to cryoablation, but is associated w/ a higher risk of permanent AV block. No significant difference in acute success. AAD indicates antiarrhythmic drug; AF, atrial fibrillation; AP, accessory pathway; AT, atrial tachycardia; AV, atrioventricular; AVJ, atrioventricular junction; AVN, atrioventricular node; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; bpm, beats per min; CA, cryoablation; CHF, congestive heart failure; CSM, carotid sinus massage; DC, direct current; ECG, electrocardiogram; ED, emergency department; EF, ejection fraction; EP, electrophysiological; FP, fast pathway; f/u, follow up; HR, heart rate; IST, inappropriate sinus tachycardia; IV, intravenous; MAT, multifocal atrial tachycardia; N/A, not applicable; NASPE, North American Society of Pacing and Electrophysiology; OR, odds ratio; PES, programmed electrical stimulation; PJRT, permanent junctional reciprocating tachycardia; PSVT, paroxysmal supraventricular tachycardia; pt, patient; RFA, radiofrequency ablation; RR, relative risk; SD, standard deviation; SHD, structural heart disease; SP, slow pathway; SR, sinus rhythm; SVT, supraventricular tachycardia; sx, symptom; VT, ventricular tachycardia; w/, with; and w/o, without.Data Supplement 11. Randomized Trials Comparing Manifest and Concealed Accessory Pathways – Section 6.1Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsHenthorn RW 1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Henthorn</Author><Year>1991</Year><RecNum>11</RecNum><IDText>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>11</Ref_ID><Title_Primary>Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group</Title_Primary><Authors_Primary>Henthorn,R.W.</Authors_Primary><Authors_Primary>Waldo,A.L.</Authors_Primary><Authors_Primary>Anderson,J.L.</Authors_Primary><Authors_Primary>Gilbert,E.M.</Authors_Primary><Authors_Primary>Alpert,B.L.</Authors_Primary><Authors_Primary>Bhandari,A.K.</Authors_Primary><Authors_Primary>Hawkinson,R.W.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Date_Primary>1991/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Double-Blind Method</Keywords><Keywords>Drug Administration Schedule</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Recurrence</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>119</Start_Page><End_Page>125</End_Page><Periodical>Circulation</Periodical><Volume>83</Volume><Issue>1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Division of Cardiology, Christ Hospital, Cincinnati, Ohio 45219</Address><Web_URL>PM:1898640</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(26)1898640 Double blind placebo controlled crossover trial of flecainide34 pts8 wk on flecainide8 wk on placebo13 w/ AVRT7 w/ AVNRT3 w/ AT28 unknownSyncopy, angina, and/or neurological sxs during tachycardia. Second or third degree AV block. NYHA CHF class III, IVFlecainide superior to placebo. Flecainide associated w/ 79% freedom from PSVT and placebo 15% p<0.001. Median time to 1st PSVT 11 d in placebo group and 55 d in flecainide group. Flecainide slowed PSVT to 143±12 bpm from 178±12 bpm on placebo. Side effects: flec 63% and placebo 36%. All not significant.Flecainide was well tolerated.Flecainide associated w/ 79% freedom from PSVT and placebo 15% p<0.001. Median time to 1st PSVT 11 d in placebo group and 55 d in flecainide group. Flecainide slowed PSVT to 143±12 bpm from 178±12 bpm on placebo. Side effects on flec 63% and placebo 36%. All not significant.Study period was briefPritchett EL 1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pritchett</Author><Year>1991</Year><RecNum>9</RecNum><IDText>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>9</Ref_ID><Title_Primary>Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy</Title_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>McCarthy,E.A.</Authors_Primary><Authors_Primary>Wilkinson,W.E.</Authors_Primary><Date_Primary>1991/4/1</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>blood</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Statistics as Topic</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>539</Start_Page><End_Page>544</End_Page><Periodical>Ann Intern Med</Periodical><Volume>114</Volume><Issue>7</Issue><ISSN_ISBN>0003-4819</ISSN_ISBN><Address>Duke University Medical Center, Durham, North Carolina</Address><Web_URL>PM:2001087</Web_URL><ZZ_JournalFull><f name="System">Annals of internal medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Ann Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(28)2001087 Double blind placebo controlled crossover trial of propafenone33 pts60 d on propafenone60 d on propafenone16 pts w/ PSVT and 17 w/ PAF. Not clear number of APNYHA class III or IV HF. Second or third degree AV block. Sxs of syncope, angina, neurological events during tachycardia.Well-designed study showing propafenone superior to placebo. Propafenone prolonged the recurrence rate of arrhythmia and was 20% the recurrence rate of placebo.No serious side effectsN/ATime to first recurrence prolonged for the propafenone group, p=0.004.The study was brief and not clear how many AP pts studied.?UK Propafenone Study Group 1995 ADDIN REFMGR.CITE <Refman><Cite><Year>1995</Year><RecNum>14</RecNum><IDText>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>14</Ref_ID><Title_Primary>A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group</Title_Primary><Date_Primary>1995/11/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>prevention & control</Keywords><Keywords>Propafenone</Keywords><Keywords>Recurrence</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>2550</Start_Page><End_Page>2557</End_Page><Periodical>Circulation</Periodical><Volume>92</Volume><Issue>9</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:7586356</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(31)7586356 Double blind, placebo controlled study of propafenone100 ptsPropafenonePlaceboPSVT 52 ptsAF 48 ptsUnclear if any AP ptsDocumented second or third degree AV block. Class III or IV HF. Sxs of syncope, angina, during tachycardiaArrhythmia recurrence. Relative risk of treatment failure for placebo compared to propafenone was 6.8 (95% CI: 2.2-21.2; p<0.001; n=45) for PSVT and 6.0 (95% CI: 1.8-20.0; p=0.004) for AF. One episode of wide QRS tachy. Not applicableRelative risk of treatment failure for placebo compared to propafenone was 6.8 (95% CI: 2.2-21.2; p<0.001; n=45) for PSVT and 6.0 (95% CI: 1.8-20.0; p=0.004) for AF.Unusual study design.Dorian P1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvcmlhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvcmlhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA (32)8607397Randomized multicenter study of verapamil vs. flecainide for treatment of PSVT121 ptsVerapamilFlecainide63 pts on flecainide and 58 verapamil. Followed for 8.1±5.1 and 7.5±5.4 mo, respectively.Prior AF, atrial flutter, myocardial infarction, unstable angina. NYHA Class III or IV CHF. Second or third degree AV block.86% of flecainide pt-mo and 73% of verapamil pt-mos w/ 0 or 1 episode of PSVT. N/AN/A30% on flecainide and 13% on verapamil were free of PSVT (p=0.026)Flecainide and verapamil were moderately effective for the prevention of PSVT.AF indicates atrial fibrillation; AP, accessory pathway; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; bpm, beats per min; CHF, congestive heart failure; CI, confidence interval; HF, heart failure; N/A, not applicable; NYHA, New York Heart Association; PAF, paroxysmal atrial fibrillation; PSVT, paroxysmal supraventricular tachycardia; pt, patient; sx, symptom; and w/, with.Data Supplement 12. Nonrandomized Trials, Observations Studies, and/or Registires of Manifest and Concealed Accessory Pathways – Section 6.1 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsRisk Stratification of Symptomatic Patients with Manifest PathwaysKlein GJ1979 ADDIN REFMGR.CITE <Refman><Cite><Author>Klein</Author><Year>1979</Year><RecNum>169</RecNum><IDText>Ventricular fibrillation in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>169</Ref_ID><Title_Primary>Ventricular fibrillation in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Bashore,T.M.</Authors_Primary><Authors_Primary>Sellers,T.D.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>Smith,W.M.</Authors_Primary><Authors_Primary>Gallagher,J.J.</Authors_Primary><Date_Primary>1979/11/15</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prevalence</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1080</Start_Page><End_Page>1085</End_Page><Periodical>N.Engl.J Med</Periodical><Volume>301</Volume><Issue>20</Issue><ISSN_ISBN>0028-4793</ISSN_ISBN><Misc_3>10.1056/NEJM197911153012003</Misc_3><Web_URL>PM:492252</Web_URL><ZZ_JournalFull><f name="System">The New England journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">N.Engl.J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(137)492252Observational study of pts w/ WPW and VF2525 WPW pts w/ VF compared to 73 pts w/oComparing EP findingsPts w/ WPW and VF had higher prevalence of AVRT (14/25 vs. 18/73, p=0.004) and multiple APs (5/25 vs. 4/73; p=0.012). The shortest preexcited RR was less in VF pts (mean RR 180 vs. 240 msec; p<0.0001) as was the mean RR (mean 269 vs. 340 msec; p<0.0001).WPW pts w/ h/o VF had more rapid AF (mean RR 180 msec) and increased prevalence of AVRT and multiple APs compared to control.Rinne E1987 ADDIN REFMGR.CITE <Refman><Cite><Author>Rinne</Author><Year>1987</Year><RecNum>172</RecNum><IDText>Relation between clinical presentation and induced arrhythmias in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>172</Ref_ID><Title_Primary>Relation between clinical presentation and induced arrhythmias in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Rinne,C.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Milstein,S.</Authors_Primary><Authors_Primary>Rattes,M.F.</Authors_Primary><Date_Primary>1987/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>complications</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>576</Start_Page><End_Page>579</End_Page><Periodical>Am J Cardiol</Periodical><Volume>60</Volume><Issue>7</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(87)90308-0</Misc_3><Web_URL>PM:3630940</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(138)3630940 Observational study of clinical vs. induced rhythms126 WPW pts w/ clinical AVRT and AF Relation between clinical and induced arrhythmiasThe shortest RR of clinical AF compared w/ the induced AF (r=0.72; p<0.00001). AVRT CL was similar (r=0.79; p<0.00001). 41% of pts w/ clinical AVRT had AF induced w/ shortest RR <250 msec. There was good reproducibility between clinical and induced AF and AVRT. Clinical AVRT pts were at high risk for rapid AF at EP study.Sharma AD 1987PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNoYXJtYTwvQXV0aG9yPjxZZWFyPjE5ODc8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNoYXJtYTwvQXV0aG9yPjxZZWFyPjE5ODc8L1llYXI+PFJl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ADDIN EN.CITE.DATA (139)3598007 Observational study comparing noninvasive and EP study67WPW pts w/ noninvasive and EP testingComparing findings of noninvasive tests and EP tests.EP study (AF w/ shortest RR<250 msec) identified 7/9 pts w/ clinical VF. Continuous preexcitation during exercise testing had a sensitivity of 80%, specificity of 28.6% and predictive accuracy of 11.8%.EP testing was more accurate than stress testing in predicting WPW pts at risk for VF. Stess testing had high sensitivity.Gaita F1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Gaita</Author><Year>1989</Year><RecNum>168</RecNum><IDText>Stress and pharmacologic tests as methods to identify patients with Wolff-Parkinson-White syndrome at risk of sudden death</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>168</Ref_ID><Title_Primary>Stress and pharmacologic tests as methods to identify patients with Wolff-Parkinson-White syndrome at risk of sudden death</Title_Primary><Authors_Primary>Gaita,F.</Authors_Primary><Authors_Primary>Giustetto,C.</Authors_Primary><Authors_Primary>Riccardi,R.</Authors_Primary><Authors_Primary>Mangiardi,L.</Authors_Primary><Authors_Primary>Brusca,A.</Authors_Primary><Date_Primary>1989/9/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>Death,Sudden</Keywords><Keywords>diagnostic use</Keywords><Keywords>etiology</Keywords><Keywords>Exercise Test</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Procainamide</Keywords><Keywords>Propafenone</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>487</Start_Page><End_Page>490</End_Page><Periodical>Am J Cardiol</Periodical><Volume>64</Volume><Issue>8</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(89)90426-8</Misc_3><Address>Istituto di Medicina e Chirurgia Cardiovascolare, Universita di Torino, Italy</Address><Web_URL>PM:2773792</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(140)2773792 Observational study of accuracy of noninvasive tests65Consecutive WPW pts studied w/ procainamide, stress testing and EP. 15 pts were asymptomatic; 50 had parison of noninvasive tests to EP findings.24 pts had high risk AF (shortest RR <250 msec, AP ERP<250 msec). Persistence of the delta wave during stress testing has a sens of 96%, spec of 17% to identify high-risk pts (PPV 40% and NPV 88%). Stress tests and IV procainamide tests had good sensitivity and NPV but low specificity and PPV for identifying high risk WPW ptsBeckman KJ1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Beckman</Author><Year>1990</Year><RecNum>167</RecNum><IDText>The predictive value of electrophysiologic studies in untreated patients with Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>167</Ref_ID><Title_Primary>The predictive value of electrophysiologic studies in untreated patients with Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Beckman,K.J.</Authors_Primary><Authors_Primary>Gallastegui,J.L.</Authors_Primary><Authors_Primary>Bauman,J.L.</Authors_Primary><Authors_Primary>Hariman,R.J.</Authors_Primary><Date_Primary>1990/3/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>complications</Keywords><Keywords>Electrophysiology</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Predictive Value of Tests</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>640</Start_Page><End_Page>647</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>15</Volume><Issue>3</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>0735-1097(90)90639-7</Misc_3><Address>Department of Medicine, University of Illinois, Chicago 60680</Address><Web_URL>PM:2303633</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(141)2303633 Observational study of ability of EP study to predict arrhythmic events42WPW pts w/ no sxs up to clinical AVRT/AF. Assessing if EP findings predicted clinical eventsDuring a f/u of 7.5±4.9 y, showed the only variables that correlated w/ subsequent arrhythmia were h/o documented arrhythmias before EP study (p<0.01) and inducible AVRT at EP study (p<0.05).H/o arrhythmia and inducible arrhythmia predict subsequent events.Pappone C2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (142)22215859 Observational study identifying risk factors in symptomatic WPW pts369 WPW pts followed to assess predictive factors from EP studyEvaluate the predictors of malignant rhythmsMean f/u 42.1±10 mo. 29 pts w/ malignant arrhythmias, 168 asymptomatic on f/u, 172 w/ AVRT/AF. Malignant arrhythmia pts had shorter AP ERP (p<0.001), AVRT triggering AF (p<0.001), and multiple APs.Short AP ERP, AVRT triggering AF, were independent predictors of malignant arrhythmias.Spar DS2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwYXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwYXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO
dW0+MTc0PC9SZWNOdW0+PElEVGV4dD5SZWxhdGlvbiBvZiB0aGUgdXRpbGl0eSBvZiBleGVyY2lz
ZSB0ZXN0aW5nIGZvciByaXNrIGFzc2Vzc21lbnQgaW4gcGVkaWF0cmljIHBhdGllbnRzIHdpdGgg
dmVudHJpY3VsYXIgcHJlZXhjaXRhdGlvbiB0byBwYXRod2F5IGxvY2F0aW9uPC9JRFRleHQ+PE1E
TCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+
MTc0PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+UmVsYXRpb24gb2YgdGhlIHV0aWxpdHkgb2YgZXhl
cmNpc2UgdGVzdGluZyBmb3IgcmlzayBhc3Nlc3NtZW50IGluIHBlZGlhdHJpYyBwYXRpZW50cyB3
aXRoIHZlbnRyaWN1bGFyIHByZWV4Y2l0YXRpb24gdG8gcGF0aHdheSBsb2NhdGlvbjwvVGl0bGVf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNwYXIsRC5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+U2lsdmVyLEUuUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PkhvcmRvZixBLkouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5MaWJlcm1hbixM
LjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAxMi80LzE8L0RhdGVfUHJpbWFyeT48
S2V5d29yZHM+QWNjZXNzb3J5IEF0cmlvdmVudHJpY3VsYXIgQnVuZGxlPC9LZXl3b3Jkcz48S2V5
d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPmFkdmVyc2UgZWZmZWN0czwvS2V5
d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbGdvcml0aG1zPC9LZXl3
b3Jkcz48S2V5d29yZHM+QXJyaHl0aG1pYXMsQ2FyZGlhYzwvS2V5d29yZHM+PEtleXdvcmRzPkNh
cmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkVs
ZWN0cm9jYXJkaW9ncmFwaHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9neTwv
S2V5d29yZHM+PEtleXdvcmRzPkV4ZXJjaXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+RXhlcmNpc2Ug
VGVzdDwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0
IEF0cmlhPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgQ29uZHVjdGlvbiBTeXN0ZW08L0tleXdv
cmRzPjxLZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48
S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRob2xvZ3k8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5QcmUtRXhjaXRhdGlvbiBTeW5kcm9tZXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrPC9LZXl3
b3Jkcz48S2V5d29yZHM+UmlzayBBc3Nlc3NtZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+V29sZmYt
UGFya2luc29uLVdoaXRlIFN5bmRyb21lPC9LZXl3b3Jkcz48S2V5d29yZHM+WW91bmcgQWR1bHQ8
L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjEwMTE8
L1N0YXJ0X1BhZ2U+PEVuZF9QYWdlPjEwMTQ8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFtIEogQ2Fy
ZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjEwOTwvVm9sdW1lPjxJc3N1ZT43PC9Jc3N1ZT48SVNT
Tl9JU0JOPjE4NzktMTkxMzwvSVNTTl9JU0JOPjxNaXNjXzM+UzAwMDItOTE0OSgxMSkwMzQ0Ni0x
OzEwLjEwMTYvai5hbWpjYXJkLjIwMTEuMTEuMDMwPC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVu
dCBvZiBQZWRpYXRyaWMgQ2FyZGlvbG9neSwgTW9yZ2FuIFN0YW5sZXkgQ2hpbGRyZW4mYXBvcztz
IEhvc3BpdGFsIE5ldyBZb3JrLVByZXNieXRlcmlhbiwgQ29sdW1iaWEgVW5pdmVyc2l0eSwgTmV3
IFlvcmssIFVTQS4gZGF2aWQuc3BhckBnbWFpbC5jb208L0FkZHJlc3M+PFdlYl9VUkw+UE06MjIy
MjE5NTQ8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+VGhlIEFtZXJp
Y2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFs
U3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+QW0gSiBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0
ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1Jl
Zm1hbj5=
ADDIN EN.CITE.DATA (143)22221954 Observational study of the utility of exercise testing 76 pediatric pts <22 y. WPW pts w/ exercise and EP testingExercise test results compared to EP findings11 pts w/ sudden loss of delta, 18 gradual, and 47 no loss during exercise. Of pts w/ 1:1 AP conduction <270 msec, none in sudden loss group and 18 in no loss group. Pts in gradual loss group more likely to have a left sided AP.Pts w/ sudden loss of preexcitation during exercise had longer 1:1 conduction when the AP blocked and none had 1:1 over the AP <270 msec.Wackel P2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhY2tlbDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhY2tlbDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE.DATA (144)22978820 Observational study of long term f/u of noninvasive tests24 pediatric pts <22 yWPW pts w/ Holter, stress test, ECG and EPNoninvasive test results compared to EP findings24 pts w/ at least one noninvasive test showing loss of preexcitation. 2 of the 24 had rapid AP conduction (1:1 over AP <260 msec). The noninvasive tests had a PPV of 92% and a NPV of 31%. 16 of 24 had loss of delta during stress test and none of those had rapid conduction at EP.Small study showed loss of preexcitation during noninvasive testing had a high PPV and specificity for slow AP conduction during EP. Pappone C2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405 Prospective single center registry of WPW pts 2169 ptsAll pts w/ a manifest AP underwent EP study±RF. Followed 8 yBoth asymptomatic and symptomatic pts studied at EP to identify risk factors for VF1001 pts (550 asymptomatic) did not undergo RF and 1168 (550 asymptomatic) underwent RF. F/u of 8 y. VF occurred in 1.5% of the no-RF group (mean age 11 y) and no VF occurred in the RF treated group (p<0.001). VF was associated w/ a short ERP of the AP w/ an optimal cut-off of 240 msec (p<0.001) and AVRT initiating AF (p<0.001).Large single center registry showing that EP findings identified pts w/ a manifest AP at high risk for VF and the risk was eliminated w/ ablation.Acute TreatmentSellers TD1977 ADDIN REFMGR.CITE <Refman><Cite><Author>Sellers</Author><Year>1977</Year><RecNum>191</RecNum><IDText>Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>191</Ref_ID><Title_Primary>Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation</Title_Primary><Authors_Primary>Sellers,T.D.,Jr.</Authors_Primary><Authors_Primary>Bashore,T.M.</Authors_Primary><Authors_Primary>Gallagher,J.J.</Authors_Primary><Date_Primary>1977/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>analysis</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Digoxin</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>therapeutic use</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>260</Start_Page><End_Page>267</End_Page><Periodical>Circulation</Periodical><Volume>56</Volume><Issue>2</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:872319</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(146)872319Acute EP study of IV digitalis effects on AF in WPW21 ptsWPW pts w/ AF induced during EP study and given IV digitalisSafety for AF in WPWDigitalis shortened the CL of the shortest preexcited RR in 6/21 pts increased the CL in 7/21 pts and had no effect in 5/21. Digitalis directly related to onset of AF degenerating to VF in 9/21 pts. Each of these 9 had a shortest RR <230 msec during AF baseline.This study is old but highlights the risk of digitalis in WPW pts w/ AFSellers TD1977 ADDIN REFMGR.CITE <Refman><Cite><Author>Sellers</Author><Year>1977</Year><RecNum>192</RecNum><IDText>Effects of procainamide and quinidine sulfate in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>192</Ref_ID><Title_Primary>Effects of procainamide and quinidine sulfate in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Sellers,T.D.,Jr.</Authors_Primary><Authors_Primary>Campbell,R.W.</Authors_Primary><Authors_Primary>Bashore,T.M.</Authors_Primary><Authors_Primary>Gallagher,J.J.</Authors_Primary><Date_Primary>1977/1</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>pharmacology</Keywords><Keywords>physiopathology</Keywords><Keywords>Procainamide</Keywords><Keywords>Quinidine</Keywords><Keywords>Research</Keywords><Keywords>therapeutic use</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>15</Start_Page><End_Page>22</End_Page><Periodical>Circulation</Periodical><Volume>55</Volume><Issue>1</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:830205</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(147)830205Single center study of IV procainamide and quinidine in WPS pts w/ induced33 ptsAll pts w/ a manifest AP and induced AFIV procainamide studied to assess effects on conduction during AFIV procainamide prolonged the shortest RR between preexcited complexes during AF by 20-70 msec in 15 of 21 pts and no change in 6 pts.IV procainamide prolonged the shortest RR between preexcited complexes in induced AFHamer A1981 ADDIN REFMGR.CITE <Refman><Cite><Author>Hamer</Author><Year>1981</Year><RecNum>184</RecNum><IDText>Effects of verapamil on supraventricular tachycardia in patients with overt and concealed Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>184</Ref_ID><Title_Primary>Effects of verapamil on supraventricular tachycardia in patients with overt and concealed Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Hamer,A.</Authors_Primary><Authors_Primary>Peter,T.</Authors_Primary><Authors_Primary>Platt,M.</Authors_Primary><Authors_Primary>Mandel,W.J.</Authors_Primary><Date_Primary>1981/5</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>chemically induced</Keywords><Keywords>drug therapy</Keywords><Keywords>Echocardiography</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Evaluation Studies as Topic</Keywords><Keywords>Female</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Keywords>Verapamil</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>600</Start_Page><End_Page>612</End_Page><Periodical>Am Heart J</Periodical><Volume>101</Volume><Issue>5</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Web_URL>PM:7223599</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(148)7223599 Single center study of IV verapamil in pts w/ AVRT19 ptsAll pts had AVRT: 12 w/ a manifest and 7 w/ a concealed APlV verapamil to assess EP changes and effects on AVRTIV verapamil prolonged refractoriness and delayed conduction in the AV node but no effect on the AP. Sustained AVRT initiated in 15 pts and terminated by verapamil in 13 pts.IV verapamil was effective in terminating AVRTHombach V1981 ADDIN REFMGR.CITE <Refman><Cite><Author>Hombach</Author><Year>1981</Year><RecNum>186</RecNum><IDText>Antiarrhythmic effects of acute betablockade with atenolol on supraventricular tachycardias at rest and during exercise</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>186</Ref_ID><Title_Primary>Antiarrhythmic effects of acute betablockade with atenolol on supraventricular tachycardias at rest and during exercise</Title_Primary><Authors_Primary>Hombach,V.</Authors_Primary><Authors_Primary>Braun,V.</Authors_Primary><Authors_Primary>Hopp,H.W.</Authors_Primary><Authors_Primary>Gil-Sanchez,D.</Authors_Primary><Authors_Primary>Behrenbeck,D.W.</Authors_Primary><Authors_Primary>Tauchert,M.</Authors_Primary><Authors_Primary>Hilger,H.H.</Authors_Primary><Date_Primary>1981/2/2</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atenolol</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>drug therapy</Keywords><Keywords>Electric Stimulation</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Exercise</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Physical Exertion</Keywords><Keywords>Propanolamines</Keywords><Keywords>Research</Keywords><Keywords>Rest</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>123</Start_Page><End_Page>133</End_Page><Periodical>Klin.Wochenschr.</Periodical><Volume>59</Volume><Issue>3</Issue><ISSN_ISBN>0023-2173</ISSN_ISBN><Web_URL>PM:7206601</Web_URL><ZZ_JournalFull><f name="System">Klinische Wochenschrift</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Klin.Wochenschr.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(149)7206601 Acute EP study of IV atenolol for treatment of induced PSVT18 ptsMixed group: 5 w/ AVRT, 2 w/ AVNRT, 6 w/ atrial flutter, 6 w/ AT, 1 w/ VTIV atenolol given for treatment of induced PSVTAtenolol was effective in preventing pacing induced AVRT in 3 of 5 pts w/ WPW. Small study published in Klin Wochenschr showing IV atenolol prevented reinduction of AVRT in 3 of 5 pts.Scheinman BD1982 ADDIN REFMGR.CITE <Refman><Cite><Author>Sheinman</Author><Year>1982</Year><RecNum>189</RecNum><IDText>Acceleration of ventricular rate by fibrillation associated with the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>189</Ref_ID><Title_Primary>Acceleration of ventricular rate by fibrillation associated with the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Sheinman,B.D.</Authors_Primary><Authors_Primary>Evans,T.</Authors_Primary><Date_Primary>1982/10/9</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Amiodarone</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Benzofurans</Keywords><Keywords>chemically induced</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>999</Start_Page><End_Page>1000</End_Page><Periodical>Br.Med J (Clin.Res Ed)</Periodical><Volume>285</Volume><Issue>6347</Issue><User_Def_5>PMC1500376</User_Def_5><ISSN_ISBN>0267-0623</ISSN_ISBN><Web_URL>PM:6812745</Web_URL><ZZ_JournalFull><f name="System">British medical journal (Clinical research ed.)</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Br.Med J (Clin.Res Ed)</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(150)6812745Case report1 ptWPW pt w/ AFIV amiodarone given to treat AFThe ventricular rate during AF increased from 170 to 230 bpmIV amiodarone accelerated the rate of AF in a pt w/ WPWMorady F, et al., 1987 ADDIN REFMGR.CITE <Refman><Cite><Author>Morady</Author><Year>1987</Year><RecNum>527</RecNum><IDText>Effect of propranolol on ventricular rate during atrial fibrillation in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>527</Ref_ID><Title_Primary>Effect of propranolol on ventricular rate during atrial fibrillation in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Morady,F.</Authors_Primary><Authors_Primary>DiCarlo,L.A.,Jr.</Authors_Primary><Authors_Primary>Baerman,J.M.</Authors_Primary><Authors_Primary>de,Buitleir M.</Authors_Primary><Date_Primary>1987/5</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Rate</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Propranolol</Keywords><Keywords>therapeutic use</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>492</Start_Page><End_Page>496</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>10</Volume><Issue>3 Pt 1</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Web_URL>PM:2439997</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(151)2439997Observational study of IV propranolol administered during AF10 ptsAll pts w/ preexcited AF.The effects of IV propranolol during preexcited AF were assessed.AF terminated in 3 of the 10 pts. The mean ventricular rate during preexcited AF was slowed by 15-56 bpm in 6 pts; no effect in 3 pts; and increased from 203 to 267 bpm in 1 pt. The authors concluded that IV propranolol should not be used in pts w/ preexcited AF if most QRS complexes are preexcited.Schutzenberger W, et al., 1987 ADDIN REFMGR.CITE <Refman><Cite><Author>Schutzenberger</Author><Year>1987</Year><RecNum>190</RecNum><IDText>Enhanced accessory pathway conduction following intravenous amiodarone in atrial fibrillation. A case report</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>190</Ref_ID><Title_Primary>Enhanced accessory pathway conduction following intravenous amiodarone in atrial fibrillation. A case report</Title_Primary><Authors_Primary>Schutzenberger,W.</Authors_Primary><Authors_Primary>Leisch,F.</Authors_Primary><Authors_Primary>Gmeiner,R.</Authors_Primary><Date_Primary>1987/7</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Amiodarone</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>complications</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>therapeutic use</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>93</Start_Page><End_Page>95</End_Page><Periodical>Int.J Cardiol</Periodical><Volume>16</Volume><Issue>1</Issue><ISSN_ISBN>0167-5273</ISSN_ISBN><Web_URL>PM:3610399</Web_URL><ZZ_JournalFull><f name="System">International journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Int.J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(152)3610399Case report1 ptWPW pt w/ AFIV amiodarone given to treat AFIV amiodarone accelerated the rate of preexcited AFIV amiodarone accelerated the rate of AF in a pt w/ WPWHuycke EC1989PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1eWNrZTwvQXV0aG9yPjxZZWFyPjE5ODk8L1llYXI+PFJl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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1eWNrZTwvQXV0aG9yPjxZZWFyPjE5ODk8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (153)2918157IV Diltiazem vs. placebo for the termination of PSVT54 pts20 pts AVNRT34 pts AVRT (19 pts w/ manifest and 15 w/ concealed APs)Safety and efficacy for termination of AVNRT and AVRTPSVT terminated in 90% of pts w/ diltiazem and 19% w/ placebo. 100% of AVNRT pts converted and 81% of AVRT pts converted. Side effects: adverse effects in 6%. IV diltiazem is safe and effective for treatment of AVRTDiMarco JP1990PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRpTWFyY288L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (114)2193560Placebo controlled study of the acute treatment of PSVT w/ adenosine and IV verapamil359 ptsPSVT pts given adenosine, placebo, or verapamil for termination. 36% had AVNRT and 64% had AVRT. 22% of pts had manifest APs.Safety and efficacy of adenosine for PSVTDose ranging study. IV adenosine doses of 6, 9, 12 mg converted 62.3%, 80.2%, and 91.4% of PSVT. Placebo converted 10.7%, 14.3%, and 16.1% w/ 4-dose sequence. In trial 2, adenosine 6 mg followed by 12 mg had success of 57.4% and 93.4% (average time to termination 30 sec). AVNRT success 92% and AVRT success 97%. 61 total pts received adenosine.IV verapamil 5 mg followed by 7.5 mg if necessary was successful in 81.3% and 91.4%. 95% pts w/ AVNRT and 96% pts w/ AVRT were successfully converted w/ verapamil. 64 total pts received verapamil; manifest pts not excluded.Side effects: 36% w/ adverse effects lasting <1 min. Severe side effects in 2.3% including flushing, chest pain, and dyspnea.Both IV adenosine and IV verapamil effective for acute treatment of AVNRT and AVRT.Furlong R1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZ1cmxvbmc8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZ1cmxvbmc8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (154)7605518 Acute prospective case series study of adenosine for termination of PSVT31 ptsPSVT of undocumented mechanismAdenosine given prehospital for management of PSVT31 pts w/ PSVT, 28 (90%) converted to sinus after the first (16) or second or third (13) dose. No significant complications reportedAdenosine was effective for treating PSVT (unclear how many pts had AVRT)Boriani G1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Boriani</Author><Year>1996</Year><RecNum>178</RecNum><IDText>Ventricular fibrillation after intravenous amiodarone in Wolff-Parkinson-White syndrome with atrial fibrillation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>178</Ref_ID><Title_Primary>Ventricular fibrillation after intravenous amiodarone in Wolff-Parkinson-White syndrome with atrial fibrillation</Title_Primary><Authors_Primary>Boriani,G.</Authors_Primary><Authors_Primary>Biffi,M.</Authors_Primary><Authors_Primary>Frabetti,L.</Authors_Primary><Authors_Primary>Azzolini,U.</Authors_Primary><Authors_Primary>Sabbatani,P.</Authors_Primary><Authors_Primary>Bronzetti,G.</Authors_Primary><Authors_Primary>Capucci,A.</Authors_Primary><Authors_Primary>Magnani,B.</Authors_Primary><Date_Primary>1996/6</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Amiodarone</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiovascular Diseases</Keywords><Keywords>chemically induced</Keywords><Keywords>complications</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Humans</Keywords><Keywords>Infusions,Intravenous</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1214</Start_Page><End_Page>1216</End_Page><Periodical>Am Heart J</Periodical><Volume>131</Volume><Issue>6</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Address>Institute of Cardiovascular Diseases, Bologna, Italy</Address><Web_URL>PM:8644602</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(155)8644602Case report 1 ptWPW pt w/ AFIV amiodarone given to treat AFIV amiodarone given to treat WPW w/ preexcited AF resulted in VFIV amiodarone resulted in ventricular fibrillationWen ZC1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051
bT4xNDY8L1JlY051bT48SURUZXh0PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5k
IGRldGVybWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94
eXNtYWwgc3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvSURUZXh0PjxNREwgUmVmX1R5cGU9
IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjE0NjwvUmVmX0lE
PjxUaXRsZV9QcmltYXJ5PkVsZWN0cm9waHlzaW9sb2dpY2FsIG1lY2hhbmlzbXMgYW5kIGRldGVy
bWluYW50cyBvZiB2YWdhbCBtYW5ldXZlcnMgZm9yIHRlcm1pbmF0aW9uIG9mIHBhcm94eXNtYWwg
c3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PldlbixaLkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuLFMuQS48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRhaSxDLlQuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5DaGlhbmcsQy5FLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+Q2hpb3UsQy5XLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hh
bmcsTS5TLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MTk5OC8xMi8xNTwvRGF0ZV9Q
cmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaW92ZW50cmljdWxh
ciBOb2RlPC9LZXl3b3Jkcz48S2V5d29yZHM+QXV0b25vbWljIFBhdGh3YXlzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QmFyb3JlZmxleDwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFs
ZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48
S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXNvcHJvdGVyZW5vbDwvS2V5d29y
ZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwvS2V5d29yZHM+
PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29y
ZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5c2lvbG9neTwvS2V5
d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlJlc2Vh
cmNoPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5U
YWNoeWNhcmRpYSxQYXJveHlzbWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3Vw
cmF2ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5WYWd1cyBOZXJ2ZTwvS2V5d29yZHM+PEtleXdvcmRzPlZhbHNhbHZhIE1hbmV1dmVyPC9L
ZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yNzE2PC9T
dGFydF9QYWdlPjxFbmRfUGFnZT4yNzIzPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5DaXJjdWxhdGlv
bjwvUGVyaW9kaWNhbD48Vm9sdW1lPjk4PC9Wb2x1bWU+PElzc3VlPjI0PC9Jc3N1ZT48SVNTTl9J
U0JOPjAwMDktNzMyMjwvSVNTTl9JU0JOPjxBZGRyZXNzPkRpdmlzaW9uIG9mIENhcmRpb2xvZ3ks
IERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIE5hdGlvbmFsIFlhbmctTWluZyBVbml2ZXJzaXR5LCBT
Y2hvb2wgb2YgTWVkaWNpbmUsIGFuZCBWZXRlcmFucyBHZW5lcmFsIEhvc3BpdGFsLVRhaXBlaSwg
VGFpd2FuPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjk4NTE5NTg8L1dlYl9VUkw+PFpaX0pvdXJuYWxT
dGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5DaXJjdWxhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRB
YmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZt
YW4+
ADDIN EN.CITE.DATA (41)9851958 Acute study of vagal maneuvers for termination of PSVT133 ptsMixed group w/ PSVT: 85 w/ AVRTEffects of vagal maneuvers on PSVT terminationOf 85 pts w/ AVRT, vagal maneuvers terminated 53%Vagal maneuvers terminate 53% of pts w/ AVRTGlatter KA2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdsYXR0ZXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdsYXR0ZXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (156)11602497 Acute study of IV ibutilide in pts w/ WPW + AF22 ptsWPW pts w/ AF at time of EP studyEP properties, safety and AF terminationIbutilide terminated AF in 95%. In 18 additional pts ibutilide prolonged the AP ERP from 275±40 to 320±60 msec p<0.01. No placebo arm. Ibutilide sass safe and effective terminating AF is WPW.Shiraishi H2002 ADDIN REFMGR.CITE <Refman><Cite><Author>Shiraishi</Author><Year>2002</Year><RecNum>193</RecNum><IDText>Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>193</Ref_ID><Title_Primary>Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Shiraishi,H.</Authors_Primary><Authors_Primary>Ishibashi,K.</Authors_Primary><Authors_Primary>Urao,N.</Authors_Primary><Authors_Primary>Hyogo,M.</Authors_Primary><Authors_Primary>Tsukamoto,M.</Authors_Primary><Authors_Primary>Keira,N.</Authors_Primary><Authors_Primary>Hirasaki,S.</Authors_Primary><Authors_Primary>Seo,Y.</Authors_Primary><Authors_Primary>Shirayama,T.</Authors_Primary><Authors_Primary>Nakagawa,M.</Authors_Primary><Date_Primary>2002/6</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>chemically induced</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiologic Techniques,Cardiac</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Tachycardia,Ventricular</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>445</Start_Page><End_Page>448</End_Page><Periodical>Intern Med</Periodical><Volume>41</Volume><Issue>6</Issue><ISSN_ISBN>0918-2918</ISSN_ISBN><Address>Kyoto Prefectural Yosanoumi Hospital</Address><Web_URL>PM:12135176</Web_URL><ZZ_JournalFull><f name="System">Internal medicine (Tokyo, Japan)</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Intern Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(157)12135176Case report 1 ptPt w/ a concealed pathway and AVRTIV verapamil given to treat AVRTIV verapamil terminated AVRT the pt developed non-sustained polymorphic VT. Authers did EP study and mechanism unknown.IV verapamil terminated AVRT in pt w/ concealed pathway but non-sustained polymorphic VT then developedNeumar RW, et al., 2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5ldW1hcjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5ldW1hcjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (158)20956224AHA ACLS GuidelinesN/AAcute treatment of pts w/ bradycardia and tachycardiaExpert developed guidelinesReviews role of direct current electrical cardioversion, vagal maneuvers and antiarrhythmic drug therapy for the treatment of supraventridular tachycardia in the emergency department including WPW w/ AF and SVTElectrical cardioversion recommended for the treatment of WPW w/ AF or SVT and hemodynamic instabilityDelaney B2011 ADDIN REFMGR.CITE <Refman><Cite><Author>Delaney</Author><Year>2011</Year><RecNum>180</RecNum><IDText>The relative efficacy of adenosine versus verapamil for the treatment of stable paroxysmal supraventricular tachycardia in adults: a meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>180</Ref_ID><Title_Primary>The relative efficacy of adenosine versus verapamil for the treatment of stable paroxysmal supraventricular tachycardia in adults: a meta-analysis</Title_Primary><Authors_Primary>Delaney,B.</Authors_Primary><Authors_Primary>Loy,J.</Authors_Primary><Authors_Primary>Kelly,A.M.</Authors_Primary><Date_Primary>2011/6</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Confidence Intervals</Keywords><Keywords>drug therapy</Keywords><Keywords>Emergencies</Keywords><Keywords>Humans</Keywords><Keywords>Hypotension</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>148</Start_Page><End_Page>152</End_Page><Periodical>Eur J Emerg.Med</Periodical><Volume>18</Volume><Issue>3</Issue><ISSN_ISBN>1473-5695</ISSN_ISBN><Misc_3>10.1097/MEJ.0b013e3283400ba2</Misc_3><Address>Joseph Epstein Centre for Emergency Medicine Research, Australia</Address><Web_URL>PM:20926952</Web_URL><ZZ_JournalFull><f name="System">European journal of emergency medicine : official journal of the European Society for Emergency Medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur J Emerg.Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(159)20926952 Meta-analysis of the efficacy of adenosine vs. verapamil for treatment of stable PSVT692 pts/eventsPSVT of undocumented mechanism8 trials included that compared verapamil and adenosineAdenosine converted 90.8% and verapamil 89.9%. More minor side effects w/ adenosine. More hypotension w/ verapamil (3.7% vs. 0.6%).Both adenosine and verapamil were effective for termination of PSVT. Verapamil had more associated hypotension.Smith GD, et al., 2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Smith</Author><Year>2013</Year><RecNum>4</RecNum><IDText>Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>4</Ref_ID><Title_Primary>Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia</Title_Primary><Authors_Primary>Smith,G.D.</Authors_Primary><Authors_Primary>Dyson,K.</Authors_Primary><Authors_Primary>Taylor,D.</Authors_Primary><Authors_Primary>Morgans,A.</Authors_Primary><Authors_Primary>Cantwell,K.</Authors_Primary><Date_Primary>2013</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>physiology</Keywords><Keywords>Randomized Controlled Trials as Topic</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Valsalva Maneuver</Keywords><Reprint>Not in File</Reprint><Start_Page>CD009502</Start_Page><Periodical>Cochrane Database Syst.Rev.</Periodical><Volume>3</Volume><ISSN_ISBN>1469-493X</ISSN_ISBN><Misc_3>10.1002/14651858.CD009502.pub2</Misc_3><Address>Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia. gavin.smith@monash.edu</Address><Web_URL>PM:23543578</Web_URL><ZZ_JournalFull><f name="System">The Cochrane database of systematic reviews</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Cochrane Database Syst.Rev.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(39)23543578Cochrane Database review of randomized trials of Valsalva316 pts iAll pts w/ SVT. Number of pts w/ AVRT was not specified.Valsalva compared to “other” vagal maneuversThe reversion of SVT to sinus rhythm following Valsalva in the 3 studies was 19.4%, 45.9%, and 54.3%Valsalva was effective in converting SVT to sinus rhythm.Long-Term Pharmacological TreatmentSellers TD1977 ADDIN REFMGR.CITE <Refman><Cite><Author>Sellers</Author><Year>1977</Year><RecNum>191</RecNum><IDText>Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>191</Ref_ID><Title_Primary>Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation</Title_Primary><Authors_Primary>Sellers,T.D.,Jr.</Authors_Primary><Authors_Primary>Bashore,T.M.</Authors_Primary><Authors_Primary>Gallagher,J.J.</Authors_Primary><Date_Primary>1977/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>analysis</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Digoxin</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>therapeutic use</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>260</Start_Page><End_Page>267</End_Page><Periodical>Circulation</Periodical><Volume>56</Volume><Issue>2</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:872319</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(146)872319 Acute EP study of IV digitalis effects on AF in WPW21 ptsWPW pts w/ AF induced during EP study and given IV digitalisSafety for AF in WPWDigitalis shortened the CL of the shortest preexcited RR in 6/21 pts increased the CL in 7/21 pts and had no effect in 5/21. Digitalis directly related to onset of AF degenerating to VF in 9/21 pts. Each of these 9 had a shortest RR <230 msec during AF baseline.This study is old but highlights the risk of digitalis in WPW pts w/ AFBauernfeind RA, et al., 1980PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdWVybmZlaW5kPC9BdXRob3I+PFllYXI+MTk4MDwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdWVybmZlaW5kPC9BdXRob3I+PFllYXI+MTk4MDwvWWVh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ADDIN EN.CITE.DATA (160)7438370Single center study of multiple drugs given IV and then long term for AV node reentry21 pts studied acutely; 18 pts followed 6-50 moAll pts w/ AV node reentryDrug efficacy at minimal f/u of 6 moPts were tested w/ IV drug to determine if the drug prevented induction of AVNRT. Successful pts were then treated long term w/ oral drugs. 18 pts followed at least 6 mo, 72% w/o recurrence: 3 of 5 pts on digoxin only; 2 of 3 pts on digoxin plus propranolol; 4 of 4 pts on propranolol only; 1 of 3 pts on procainamide; and 3 of 3 pts on quinidine only.Small number of pts on each medication showing moderate success.Sakurai M1983 ADDIN REFMGR.CITE <Refman><Cite><Author>Sakurai</Author><Year>1983</Year><RecNum>199</RecNum><IDText>Acute and chronic effects of verapamil in patients with paroxysmal supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>199</Ref_ID><Title_Primary>Acute and chronic effects of verapamil in patients with paroxysmal supraventricular tachycardia</Title_Primary><Authors_Primary>Sakurai,M.</Authors_Primary><Authors_Primary>Yasuda,H.</Authors_Primary><Authors_Primary>Kato,N.</Authors_Primary><Authors_Primary>Nomura,A.</Authors_Primary><Authors_Primary>Fujita,M.</Authors_Primary><Authors_Primary>Nishino,T.</Authors_Primary><Authors_Primary>Fujita,K.</Authors_Primary><Authors_Primary>Koike,Y.</Authors_Primary><Authors_Primary>Saito,H.</Authors_Primary><Date_Primary>1983/4</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>blood</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Injections,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>619</Start_Page><End_Page>628</End_Page><Periodical>Am Heart J</Periodical><Volume>105</Volume><Issue>4</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Web_URL>PM:6837416</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(161)6837416Single center study of IV and oral verapamil for PSVT15 pts studied acutely and followed 3 to 31 mo (mean 15 mo)AVNRT in 4 and AVRT in 11 (all w/ a concealed AP)Drug efficacy at minimal f/u of 3 mo13 pts followed 3-31 (mean 15) mo w/ 8 having no recurrent PSVT and 5 having decreased frequency and duration. Mild constipation in 4.Small, uncontrolled study of oral verapamil for PSVT including some pts w/ AVRTFeld GK1984 ADDIN REFMGR.CITE <Refman><Cite><Author>Feld</Author><Year>1984</Year><RecNum>196</RecNum><IDText>Electrophysiologic basis for the suppression by amiodarone of orthodromic supraventricular tachycardias complicating pre-excitation syndromes</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>196</Ref_ID><Title_Primary>Electrophysiologic basis for the suppression by amiodarone of orthodromic supraventricular tachycardias complicating pre-excitation syndromes</Title_Primary><Authors_Primary>Feld,G.K.</Authors_Primary><Authors_Primary>Nademanee,K.</Authors_Primary><Authors_Primary>Weiss,J.</Authors_Primary><Authors_Primary>Stevenson,W.</Authors_Primary><Authors_Primary>Singh,B.N.</Authors_Primary><Date_Primary>1984/5</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Amiodarone</Keywords><Keywords>Benzofurans</Keywords><Keywords>complications</Keywords><Keywords>Digoxin</Keywords><Keywords>drug effects</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Pre-Excitation Syndromes</Keywords><Keywords>Propranolol</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1298</Start_Page><End_Page>1307</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>3</Volume><Issue>5</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Web_URL>PM:6707383</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(162)6707383EP testing after amiodarone loading and then long term f/u10 ptsEP test at ≥4 wkAll pts w/ AP and AVRTAssessment of EP properties9 pts no longer had inducible AVRT. 1 pt had nonsustained AVRT. AP ERP increased by 20% anterograde p<0.05 and 40% retrograde p<0.02 symptomatic control of arrhythmia during 20 mo. 1 pt stopped due to side effectsAmiodarone had favorable effects on AP and long-term rhythm control. Small number of ptsFeld GK 1988PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZlbGQ8L0F1dGhvcj48WWVhcj4xOTg4PC9ZZWFyPjxSZWNO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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZlbGQ8L0F1dGhvcj48WWVhcj4xOTg4PC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (163)3336964EP testing and long term assessment of amiodarone10 ptsAcute EP study and mean 30 mo f/uAll pts w/ WPW and AF w/ a rapid ventricular responseEP measurement of drug effect and long term f/u of rhythm controlEP study—amiodarone prolonged the AP ERP 38% (p<0.01) and atrial ERP 34% (p<0.01). Amiodarone prolonged the mean RR 90% and minimum RR 104% (p<0.01) during AF.Long-term f/u—no AF or VF. SVT in 1 who went to surgery.1 serious and 5 minor side effectsAmiodarone was safe and effective preventing AF in a small number of pts although side effect were significant.Chimienti M 1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoaW1pZW50aTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+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ADDIN EN.CITE.DATA (30)8682031 Open label, no placebo comparison of flecainide vs. propafenone335 pts12 mo mean f/uPSVT 135PAF 200Unclear number of AVRT or WPWArrhythmia recurrenceProbability of 12 mo safe and effective treatment for PSVT was 93% for flecainide and 86% for propafenone p=0.24. For AF it was 77% for flecainide and 75% for propafenone p=0.72. One VT on propafenone, Two rapid AF on flecainidePropafenone and flecainide had similar efficacy for PSVT and AF Hopson JR 1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvcHNvbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvcHNvbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl
Y051bT4xOTg8L1JlY051bT48SURUZXh0PlNhZmV0eSBhbmQgdXRpbGl0eSBvZiBmbGVjYWluaWRl
IGFjZXRhdGUgaW4gdGhlIHJvdXRpbmUgY2FyZSBvZiBwYXRpZW50cyB3aXRoIHN1cHJhdmVudHJp
Y3VsYXIgdGFjaHlhcnJoeXRobWlhczogcmVzdWx0cyBvZiBhIG11bHRpY2VudGVyIHRyaWFsLiBU
aGUgRmxlY2FpbmlkZSBTdXByYXZlbnRyaWN1bGFyIFRhY2h5Y2FyZGlhIFN0dWR5IEdyb3VwPC9J
RFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBl
PjxSZWZfSUQ+MTk4PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+U2FmZXR5IGFuZCB1dGlsaXR5IG9m
IGZsZWNhaW5pZGUgYWNldGF0ZSBpbiB0aGUgcm91dGluZSBjYXJlIG9mIHBhdGllbnRzIHdpdGgg
c3VwcmF2ZW50cmljdWxhciB0YWNoeWFycmh5dGhtaWFzOiByZXN1bHRzIG9mIGEgbXVsdGljZW50
ZXIgdHJpYWwuIFRoZSBGbGVjYWluaWRlIFN1cHJhdmVudHJpY3VsYXIgVGFjaHljYXJkaWEgU3R1
ZHkgR3JvdXA8L1RpdGxlX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Ib3Bzb24sSi5SLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QnV4dG9uLEEuRS48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5PlJpbmtlbmJlcmdlcixSLkwuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5OYWRlbWFuZWUsSy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PkhlaWxtYW4sSi5NLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+S2llbnps
ZSxNLkcuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk2LzEvMjU8L0RhdGVfUHJp
bWFyeT48S2V5d29yZHM+YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdlPC9LZXl3b3Jkcz48S2V5
d29yZHM+QWRtaW5pc3RyYXRpb24sT3JhbDwvS2V5d29yZHM+PEtleXdvcmRzPkFkb2xlc2NlbnQ8
L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPmFkdmVyc2UgZWZm
ZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkLDgw
IGFuZCBvdmVyPC9LZXl3b3Jkcz48S2V5d29yZHM+QW50aS1BcnJoeXRobWlhIEFnZW50czwvS2V5
d29yZHM+PEtleXdvcmRzPkFycmh5dGhtaWFzLENhcmRpYWM8L0tleXdvcmRzPjxLZXl3b3Jkcz5B
dHJpYWwgRmlicmlsbGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZsdXR0ZXI8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5jaGVtaWNhbGx5IGluZHVjZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5E
aXNlYXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+RGl6emluZXNzPC9LZXl3b3Jkcz48S2V5d29yZHM+
ZHJ1ZyB0aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29y
ZHM+RmxlY2FpbmlkZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48S2V5d29y
ZHM+SGVhcnQgRmFpbHVyZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtl
eXdvcmRzPklvd2E8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+
TWVkaWNpbmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdv
cmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzazwvS2V5d29yZHM+PEtleXdvcmRz
PlNhZmV0eTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29y
ZHM+VGFjaHljYXJkaWEsRWN0b3BpYyBBdHJpYWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNh
cmRpYSxQYXJveHlzbWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3VwcmF2ZW50
cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PEtl
eXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5Vbml0ZWQgU3RhdGVzPC9LZXl3b3Jk
cz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT43MkE8L1N0YXJ0X1Bh
Z2U+PEVuZF9QYWdlPjgyQTwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+QW0gSiBDYXJkaW9sPC9QZXJp
b2RpY2FsPjxWb2x1bWU+Nzc8L1ZvbHVtZT48SXNzdWU+MzwvSXNzdWU+PElTU05fSVNCTj4wMDAy
LTkxNDk8L0lTU05fSVNCTj48TWlzY18zPlMwMDAyOTE0OTk3ODkxMjE3PC9NaXNjXzM+PEFkZHJl
c3M+RGVwYXJ0bWVudCBvZiBJbnRlcm5hbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBJb3dhIEhv
c3BpdGFscyBhbmQgQ2xpbmljcywgSW93YSBDaXR5IDUyMjQyLCBVU0E8L0FkZHJlc3M+PFdlYl9V
Ukw+UE06ODYwNzM5NTwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5U
aGUgQW1lcmljYW4gam91cm5hbCBvZiBjYXJkaW9sb2d5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpa
X0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5BbSBKIENhcmRpb2w8L2Y+PC9aWl9K
b3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9D
aXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (164)8607395Open-label multicenter trial of flecainide151 pts1 yPSVT 67PAF 67CAF 17, unclear number of AVRT or WPWArrhythmia recurrenceAt 1 y of treatment, 87% of PSVT, 73% of PAF, and 56% of CAF had improved symptomatically. Proarrhythmia is 3, CHF in 7. 65% w/ visual sx or headachePoor study design, flecainide effective but important cardiac events. Study done before results of CAST known.Catheter Ablation: Ablation of Standard APsJackman WM 1991PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFyPjxS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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphY2ttYW48L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (165)2030716Observational study of RF ablation and short term f/u for WPW166166 WPW pts w/ 177 pathwaysAcute ablation success and at 8 moAP conduction eliminated in 164 of 166 pts (99%) by a median of 3 RF applications. F/u at 8±5.4 mo showed preexcitation or AVRT returned in 15 pts who underwent a 2nd RF. EP study at 3±9 mo after RF in 75 pts verified absence of AP. 3 pts (1.8%) w/ complications – AV block, cardiac tamponade, pericarditis.Large series reporting success and safety of RF for treating AP in WPW.Calkins H1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (166)1555278 Observational study of RF in WPW250183 pts w/ manifest AP and 84 concealed. Failed 2.0+/-1.6 AADsAcute, 3 mo EP study, and 10±4 mo success250 pts w/ 267 APs. 94% w/ both acute success and free of tachycardia at 10 mo. 4% w/ complications: MI-1, AV block-3, valve damage-1, TIA-1, vascular-2Large series reporting success and safety of RF in pts w/ APsKugler J1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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 EN.CITE.DATA (167)8164700Observational multicenter study of RF ablations in young pts SVT652615 APsAcute and short-term f/u 13.5 moSuccess highest in left free wall APs (89%), high volume centers; lowest in right free wall AP’s (69%), pt weight >80 kg, or presence of CHD. Recurrence in 12-40%, higher in right free wall AP or presence of CHD. 3.7%; one procedural death; AV block, pericardial eff/usion; higher if weight <15 kg; One post procedural death in 5 wk old infant w/ torn mitral valve.Large multicenter series, RF acceptable treatment for AP w/ attention to pt age and body weight and center experience. Calkins H1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (59)9892593 Multicenter observational study of RF using Atakr for PSVT1050500 pts w/ AP; 373 w/ AVNRT; 121 of AV junctionAcute and long term safety and f/u.; median f/u 6.3 moAcute AP success 93% for single APs and 86% for multiple APs. 7.8% of pts w/ AP had a recurrence. 3% w/ major complication and 8.2% minor. Death-3, stroke-2, AV block-10, tamponade-6, valve damage-1, MI-1Large series showing good acute success, 8% recurrence, and major complications in 3%. This is the most accurate study listing complications.Dagres N1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhZ3JlczwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl
Y051bT4yMDU8L1JlY051bT48SURUZXh0PlJhZGlvZnJlcXVlbmN5IGNhdGhldGVyIGFibGF0aW9u
IG9mIGFjY2Vzc29yeSBwYXRod2F5cy4gT3V0Y29tZSBhbmQgdXNlIG9mIGFudGlhcnJoeXRobWlj
IGRydWdzIGR1cmluZyBmb2xsb3ctdXA8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48
UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4yMDU8L1JlZl9JRD48VGl0bGVfUHJp
bWFyeT5SYWRpb2ZyZXF1ZW5jeSBjYXRoZXRlciBhYmxhdGlvbiBvZiBhY2Nlc3NvcnkgcGF0aHdh
eXMuIE91dGNvbWUgYW5kIHVzZSBvZiBhbnRpYXJyaHl0aG1pYyBkcnVncyBkdXJpbmcgZm9sbG93
LXVwPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RGFncmVzLE4uPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DbGFndWUsSi5SLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+S290dGthbXAsSC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PkhpbmRyaWNrcyxHLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QnJlaXRoYXJk
dCxHLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Qm9yZ2dyZWZlLE0uPC9BdXRo
b3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk5LzEyPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRz
PkFkb2xlc2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRz
PkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkLDgwIGFuZCBvdmVyPC9LZXl3b3Jkcz48S2V5
d29yZHM+QW50aS1BcnJoeXRobWlhIEFnZW50czwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlvdmVu
dHJpY3VsYXIgTm9kZTwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5DYXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkPC9LZXl3
b3Jkcz48S2V5d29yZHM+ZHJ1ZyB0aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb2Nh
cmRpb2dyYXBoeTwvS2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRz
PkZvbGxvdy1VcCBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+R2VybWFueTwvS2V5d29yZHM+
PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3
b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5QYXRpZW50czwvS2V5d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5
d29yZHM+PEtleXdvcmRzPnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwvS2V5d29yZHM+PEtleXdv
cmRzPlF1ZXN0aW9ubmFpcmVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJyZW5jZTwvS2V5d29y
ZHM+PEtleXdvcmRzPlJlc2VhcmNoPC9LZXl3b3Jkcz48S2V5d29yZHM+UmV0cm9zcGVjdGl2ZSBT
dHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlRh
Y2h5Y2FyZGlhLEF0cmlvdmVudHJpY3VsYXIgTm9kYWwgUmVlbnRyeTwvS2V5d29yZHM+PEtleXdv
cmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PEtleXdvcmRzPlRyZWF0bWVudCBPdXRjb21l
PC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4xODI2
PC9TdGFydF9QYWdlPjxFbmRfUGFnZT4xODMyPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5FdXIgSGVh
cnQgSjwvUGVyaW9kaWNhbD48Vm9sdW1lPjIwPC9Wb2x1bWU+PElzc3VlPjI0PC9Jc3N1ZT48SVNT
Tl9JU0JOPjAxOTUtNjY4WDwvSVNTTl9JU0JOPjxNaXNjXzM+MTAuMTA1My9ldWhqLjE5OTkuMTc0
OTtTMDE5NTY2OFg5OTkxNzQ5OTwvTWlzY18zPjxBZGRyZXNzPlRoZSBEZXBhcnRtZW50IG9mIENh
cmRpb2xvZ3kgYW5kIEFuZ2lvbG9neSwgSG9zcGl0YWwgb2YgdGhlIFdlc3RmYWxpc2NoZSBXaWxo
ZWxtcy1Vbml2ZXJzaXR5IGFuZCBJbnN0aXR1dGUgZm9yIEFydGVyaW9zY2xlcm9zaXMgUmVzZWFy
Y2gsIE11bnN0ZXIsIEdlcm1hbnk8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTA1ODExNDE8L1dlYl9V
Ukw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+RXVyb3BlYW4gaGVhcnQgam91cm5h
bDwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3Rl
bSI+RXVyIEhlYXJ0IEo8L2Y+PC9aWl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8
L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPm==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhZ3JlczwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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ADDIN EN.CITE.DATA (168)10581141Observational study of RF for APs519All pts w/ APsAcute and long term f/u at 22.6±12.4 mo398 pts responded to f/u questionnaire. 85.4% asymptomatic and 10.6% taking AADs. 41% of pts w/ failed ablations were asymptomatic.Large series reporting good long term success w/ RF for APsSchlapfer J2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Schlapfer</Author><Year>2001</Year><RecNum>209</RecNum><IDText>Late clinical outcome after successful radiofrequency catheter ablation of accessory pathways</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>209</Ref_ID><Title_Primary>Late clinical outcome after successful radiofrequency catheter ablation of accessory pathways</Title_Primary><Authors_Primary>Schlapfer,J.</Authors_Primary><Authors_Primary>Fromer,M.</Authors_Primary><Date_Primary>2001/4</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>diagnosis</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patient Satisfaction</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Recurrence</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>605</Start_Page><End_Page>609</End_Page><Periodical>Eur Heart J</Periodical><Volume>22</Volume><Issue>7</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Misc_3>10.1053/euhj.2000.2409;S0195668X00924096</Misc_3><Address>Division of Cardiology, University Hospital, Lausanne, Switzerland</Address><Web_URL>PM:11259148</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(169)11259148Observational study of RF for APs followed long term180Pts. w/ APs undergoing RF failing 1.75+/- 1.25 AADsLong-term f/u at a median of 48.1 moAll pts has successful procedure. Pts followed median of 48.1 mo—79% remained asymptomatic. 10% required further RF’ or meds. 4% w/ procedure complications: vascular-5, valve perforation-1, TIA-2Large study of acute RF success w/ 21% having sxs by 4 y but only 10% requiring additional therapy.Belhassen B 2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlbGhhc3NlbjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+
PFJlY051bT4yMDE8L1JlY051bT48SURUZXh0PlJhZGlvZnJlcXVlbmN5IGFibGF0aW9uIG9mIGFj
Y2Vzc29yeSBwYXRod2F5czogYSAxNCB5ZWFyIGV4cGVyaWVuY2UgYXQgdGhlIFRlbCBBdml2IE1l
ZGljYWwgQ2VudGVyIGluIDUwOCBwYXRpZW50czwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJu
YWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjIwMTwvUmVmX0lEPjxUaXRs
ZV9QcmltYXJ5PlJhZGlvZnJlcXVlbmN5IGFibGF0aW9uIG9mIGFjY2Vzc29yeSBwYXRod2F5czog
YSAxNCB5ZWFyIGV4cGVyaWVuY2UgYXQgdGhlIFRlbCBBdml2IE1lZGljYWwgQ2VudGVyIGluIDUw
OCBwYXRpZW50czwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkJlbGhhc3NlbixCLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Um9nb3dza2ksTy48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PkdsaWNrLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5WaXNraW4sUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PklsYW4s
TS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJvc3NvLFIuPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5FbGRhcixNLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1By
aW1hcnk+MjAwNy80PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRz
PjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5BcnJoeXRobWlhcyxDYXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlhYyBDYXRo
ZXRlcml6YXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9sb2d5PC9LZXl3b3Jkcz48S2V5
d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29y
ZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2Fy
ZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+
Rm9sbG93LVVwIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydCBDb25kdWN0aW9uIFN5
c3RlbTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5I
dW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Jc3JhZWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxl
PC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBB
Z2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlz
aW9wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5TYWZldHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3
b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRzPlRpbWUgRmFjdG9yczwv
S2V5d29yZHM+PEtleXdvcmRzPlRyZWF0bWVudCBPdXRjb21lPC9LZXl3b3Jkcz48UmVwcmludD5O
b3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yNjU8L1N0YXJ0X1BhZ2U+PEVuZF9QYWdl
PjI3MDwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+SXNyLk1lZCBBc3NvYy5KPC9QZXJpb2RpY2FsPjxW
b2x1bWU+OTwvVm9sdW1lPjxJc3N1ZT40PC9Jc3N1ZT48SVNTTl9JU0JOPjE1NjUtMTA4ODwvSVNT
Tl9JU0JOPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVGVsIEF2aXYgU291cmFz
a3kgTWVkaWNhbCBDZW50ZXIsIFRlbCBBdml2LCBJc3JhZWwuIGJibGhhc3NAdGFzbWMuaGVhbHRo
Lmdvdi5pbDwvQWRkcmVzcz48V2ViX1VSTD5QTToxNzQ5MTIxOTwvV2ViX1VSTD48WlpfSm91cm5h
bEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5UaGUgSXNyYWVsIE1lZGljYWwgQXNzb2NpYXRpb24gam91
cm5hbCA6IElNQUo8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBu
YW1lPSJTeXN0ZW0iPklzci5NZWQgQXNzb2MuSjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpa
X1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+AG==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlbGhhc3NlbjwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+
PFJlY051bT4yMDE8L1JlY051bT48SURUZXh0PlJhZGlvZnJlcXVlbmN5IGFibGF0aW9uIG9mIGFj
Y2Vzc29yeSBwYXRod2F5czogYSAxNCB5ZWFyIGV4cGVyaWVuY2UgYXQgdGhlIFRlbCBBdml2IE1l
ZGljYWwgQ2VudGVyIGluIDUwOCBwYXRpZW50czwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJu
YWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjIwMTwvUmVmX0lEPjxUaXRs
ZV9QcmltYXJ5PlJhZGlvZnJlcXVlbmN5IGFibGF0aW9uIG9mIGFjY2Vzc29yeSBwYXRod2F5czog
YSAxNCB5ZWFyIGV4cGVyaWVuY2UgYXQgdGhlIFRlbCBBdml2IE1lZGljYWwgQ2VudGVyIGluIDUw
OCBwYXRpZW50czwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkJlbGhhc3NlbixCLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Um9nb3dza2ksTy48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PkdsaWNrLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5WaXNraW4sUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PklsYW4s
TS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJvc3NvLFIuPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5FbGRhcixNLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1By
aW1hcnk+MjAwNy80PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRz
PjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5BcnJoeXRobWlhcyxDYXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlhYyBDYXRo
ZXRlcml6YXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9sb2d5PC9LZXl3b3Jkcz48S2V5
d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29y
ZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2Fy
ZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+
Rm9sbG93LVVwIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydCBDb25kdWN0aW9uIFN5
c3RlbTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5I
dW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Jc3JhZWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxl
PC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBB
Z2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlz
aW9wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5TYWZldHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3
b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRzPlRpbWUgRmFjdG9yczwv
S2V5d29yZHM+PEtleXdvcmRzPlRyZWF0bWVudCBPdXRjb21lPC9LZXl3b3Jkcz48UmVwcmludD5O
b3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yNjU8L1N0YXJ0X1BhZ2U+PEVuZF9QYWdl
PjI3MDwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+SXNyLk1lZCBBc3NvYy5KPC9QZXJpb2RpY2FsPjxW
b2x1bWU+OTwvVm9sdW1lPjxJc3N1ZT40PC9Jc3N1ZT48SVNTTl9JU0JOPjE1NjUtMTA4ODwvSVNT
Tl9JU0JOPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVGVsIEF2aXYgU291cmFz
a3kgTWVkaWNhbCBDZW50ZXIsIFRlbCBBdml2LCBJc3JhZWwuIGJibGhhc3NAdGFzbWMuaGVhbHRo
Lmdvdi5pbDwvQWRkcmVzcz48V2ViX1VSTD5QTToxNzQ5MTIxOTwvV2ViX1VSTD48WlpfSm91cm5h
bEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5UaGUgSXNyYWVsIE1lZGljYWwgQXNzb2NpYXRpb24gam91
cm5hbCA6IElNQUo8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBu
YW1lPSJTeXN0ZW0iPklzci5NZWQgQXNzb2MuSjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpa
X1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+AG==
ADDIN EN.CITE.DATA (170)17491219Observational study of RF for APs508508 pts w/ 535 APs.Acute and long term RF results 85±43 mo f/u46.8% manifest and 44.4% concealed. 572 procedures in the 508 pts. Acute RF success 93.1% and multiple RF 95.3%. 9.9% recurrence after 1st RF. At 85 mo f/u, 94.9% cure. 2 major complications—pericardial effusion, MILarge series showing long-term success and safety of RF for APs. Pappone C, et al., 2014 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+MTcxPC9SZWNOdW0+PElEVGV4dD5Xb2xmZi1QYXJraW5zb24td2hpdGUgc3luZHJvbWUg
aW4gdGhlIGVyYSBvZiBjYXRoZXRlciBhYmxhdGlvbjogaW5zaWdodHMgZnJvbSBhIHJlZ2lzdHJ5
IHN0dWR5IG9mIDIxNjkgcGF0aWVudHM8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48
UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4xNzE8L1JlZl9JRD48VGl0bGVfUHJp
bWFyeT5Xb2xmZi1QYXJraW5zb24td2hpdGUgc3luZHJvbWUgaW4gdGhlIGVyYSBvZiBjYXRoZXRl
ciBhYmxhdGlvbjogaW5zaWdodHMgZnJvbSBhIHJlZ2lzdHJ5IHN0dWR5IG9mIDIxNjkgcGF0aWVu
dHM8L1RpdGxlX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5QYXBwb25lLEMuPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5WaWNlZG9taW5pLEcuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5NYW5ndXNvLEYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5TYXZpYW5vLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5CYWxkaSxNLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+UGFwcG9uZSxBLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2lhY2NpbyxDLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+R2lhbm5lbGxpLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5J
b25lc2N1LEIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5QZXRyZXR0YSxBLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Vml0YWxlLFIuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5DdWtvLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5DYWxvdmljLFouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5GdW5kYWxp
b3RpcyxBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TW9zY2F0aWVsbG8sTS48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRhdmF6emksTC48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PlNhbnRpbmVsbGksVi48L0F1dGhvcnNfUHJpbWFyeT48RGF0
ZV9QcmltYXJ5PjIwMTQvOS8yPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkF0cmlhbCBGaWJyaWxs
YXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+
Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5JdGFseTwvS2V5d29yZHM+PEtl
eXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5d29yZHM+PEtl
eXdvcmRzPlByb2dub3NpczwvS2V5d29yZHM+PEtleXdvcmRzPlByb3NwZWN0aXZlIFN0dWRpZXM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWdpc3RyaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVzZWFy
Y2g8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzayBGYWN0
b3JzPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5W
ZW50cmljdWxhciBGaWJyaWxsYXRpb248L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9S
ZXByaW50PjxTdGFydF9QYWdlPjgxMTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+ODE5PC9FbmRfUGFn
ZT48UGVyaW9kaWNhbD5DaXJjdWxhdGlvbjwvUGVyaW9kaWNhbD48Vm9sdW1lPjEzMDwvVm9sdW1l
PjxJc3N1ZT4xMDwvSXNzdWU+PElTU05fSVNCTj4xNTI0LTQ1Mzk8L0lTU05fSVNCTj48TWlzY18z
PkNJUkNVTEFUSU9OQUhBLjExNC4wMTExNTQ7MTAuMTE2MS9DSVJDVUxBVElPTkFIQS4xMTQuMDEx
MTU0PC9NaXNjXzM+PEFkZHJlc3M+RnJvbSB0aGUgRGVwYXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5
LCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFsLCBHVk0gQ2FyZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9s
YSwgSXRhbHkgKEMuUC4sIEcuVi4sIEYuTS4sIE0uUy4sIE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4s
IEIuSS4sIEEuUC4sIFIuVi4sIEEuQy4sIFouQy4sIE0uTS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xp
bmljYWwgQ2FyZGlvbG9neSwgVW5pdmVyc2l0YSBkZWwgUGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5v
dmFyYSwgSXRhbHkgKEEuRi4pLiBjcGFwcG9uZUBndm1uZXQuaXQmI3hBO0Zyb20gdGhlIERlcGFy
dG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFyaWEgQ2VjaWxpYSBIb3NwaXRhbCwgR1ZNIENhcmUg
YW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0YWx5IChDLlAuLCBHLlYuLCBGLk0uLCBNLlMuLCBN
LkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkkuLCBBLlAuLCBSLlYuLCBBLkMuLCBaLkMuLCBNLk0u
LCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2FsIENhcmRpb2xvZ3ksIFVuaXZlcnNpdGEgZGVsIFBp
ZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEsIEl0YWx5IChBLkYuKSYjeEE7RnJvbSB0aGUgRGVw
YXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5LCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFsLCBHVk0gQ2Fy
ZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9sYSwgSXRhbHkgKEMuUC4sIEcuVi4sIEYuTS4sIE0uUy4s
IE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4sIEIuSS4sIEEuUC4sIFIuVi4sIEEuQy4sIFouQy4sIE0u
TS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xpbmljYWwgQ2FyZGlvbG9neSwgVW5pdmVyc2l0YSBkZWwg
UGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5vdmFyYSwgSXRhbHkgKEEuRi4pJiN4QTtGcm9tIHRoZSBE
ZXBhcnRtZW50IG9mIEFycmh5dGhtb2xvZ3ksIE1hcmlhIENlY2lsaWEgSG9zcGl0YWwsIEdWTSBD
YXJlIGFuZCBSZXNlYXJjaCwgQ290aWdub2xhLCBJdGFseSAoQy5QLiwgRy5WLiwgRi5NLiwgTS5T
LiwgTS5CLiwgQS5QLiwgQy5DLiwgTC5HLiwgQi5JLiwgQS5QLiwgUi5WLiwgQS5DLiwgWi5DLiwg
TS5NLiwgTC5ULiwgVi5TLik7IGFuZCBDbGluaWNhbCBDYXJkaW9sb2d5LCBVbml2ZXJzaXRhIGRl
bCBQaWVtb250ZSBBLiBBdm9nYWRybywgTm92YXJhLCBJdGFseSAoQS5GLikmI3hBO0Zyb20gdGhl
IERlcGFydG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFyaWEgQ2VjaWxpYSBIb3NwaXRhbCwgR1ZN
IENhcmUgYW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0YWx5IChDLlAuLCBHLlYuLCBGLk0uLCBN
LlMuLCBNLkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkkuLCBBLlAuLCBSLlYuLCBBLkMuLCBaLkMu
LCBNLk0uLCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2FsIENhcmRpb2xvZ3ksIFVuaXZlcnNpdGEg
ZGVsIFBpZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEsIEl0YWx5IChBLkYuKSYjeEE7RnJvbSB0
aGUgRGVwYXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5LCBNYXJpYSBDZWNpbGlhIEhvc3BpdGFsLCBH
Vk0gQ2FyZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9sYSwgSXRhbHkgKEMuUC4sIEcuVi4sIEYuTS4s
IE0uUy4sIE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4sIEIuSS4sIEEuUC4sIFIuVi4sIEEuQy4sIFou
Qy4sIE0uTS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xpbmljYWwgQ2FyZGlvbG9neSwgVW5pdmVyc2l0
YSBkZWwgUGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5vdmFyYSwgSXRhbHkgKEEuRi4pJiN4QTtGcm9t
IHRoZSBEZXBhcnRtZW50IG9mIEFycmh5dGhtb2xvZ3ksIE1hcmlhIENlY2lsaWEgSG9zcGl0YWws
IEdWTSBDYXJlIGFuZCBSZXNlYXJjaCwgQ290aWdub2xhLCBJdGFseSAoQy5QLiwgRy5WLiwgRi5N
LiwgTS5TLiwgTS5CLiwgQS5QLiwgQy5DLiwgTC5HLiwgQi5JLiwgQS5QLiwgUi5WLiwgQS5DLiwg
Wi5DLiwgTS5NLiwgTC5ULiwgVi5TLik7IGFuZCBDbGluaWNhbCBDYXJkaW9sb2d5LCBVbml2ZXJz
aXRhIGRlbCBQaWVtb250ZSBBLiBBdm9nYWRybywgTm92YXJhLCBJdGFseSAoQS5GLikmI3hBO0Zy
b20gdGhlIERlcGFydG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFyaWEgQ2VjaWxpYSBIb3NwaXRh
bCwgR1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0YWx5IChDLlAuLCBHLlYuLCBG
Lk0uLCBNLlMuLCBNLkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkkuLCBBLlAuLCBSLlYuLCBBLkMu
LCBaLkMuLCBNLk0uLCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2FsIENhcmRpb2xvZ3ksIFVuaXZl
cnNpdGEgZGVsIFBpZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEsIEl0YWx5IChBLkYuKSYjeEE7
RnJvbSB0aGUgRGVwYXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5LCBNYXJpYSBDZWNpbGlhIEhvc3Bp
dGFsLCBHVk0gQ2FyZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9sYSwgSXRhbHkgKEMuUC4sIEcuVi4s
IEYuTS4sIE0uUy4sIE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4sIEIuSS4sIEEuUC4sIFIuVi4sIEEu
Qy4sIFouQy4sIE0uTS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xpbmljYWwgQ2FyZGlvbG9neSwgVW5p
dmVyc2l0YSBkZWwgUGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5vdmFyYSwgSXRhbHkgKEEuRi4pJiN4
QTtGcm9tIHRoZSBEZXBhcnRtZW50IG9mIEFycmh5dGhtb2xvZ3ksIE1hcmlhIENlY2lsaWEgSG9z
cGl0YWwsIEdWTSBDYXJlIGFuZCBSZXNlYXJjaCwgQ290aWdub2xhLCBJdGFseSAoQy5QLiwgRy5W
LiwgRi5NLiwgTS5TLiwgTS5CLiwgQS5QLiwgQy5DLiwgTC5HLiwgQi5JLiwgQS5QLiwgUi5WLiwg
QS5DLiwgWi5DLiwgTS5NLiwgTC5ULiwgVi5TLik7IGFuZCBDbGluaWNhbCBDYXJkaW9sb2d5LCBV
bml2ZXJzaXRhIGRlbCBQaWVtb250ZSBBLiBBdm9nYWRybywgTm92YXJhLCBJdGFseSAoQS5GLikm
I3hBO0Zyb20gdGhlIERlcGFydG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFyaWEgQ2VjaWxpYSBI
b3NwaXRhbCwgR1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0YWx5IChDLlAuLCBH
LlYuLCBGLk0uLCBNLlMuLCBNLkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkkuLCBBLlAuLCBSLlYu
LCBBLkMuLCBaLkMuLCBNLk0uLCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2FsIENhcmRpb2xvZ3ks
IFVuaXZlcnNpdGEgZGVsIFBpZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEsIEl0YWx5IChBLkYu
KSYjeEE7RnJvbSB0aGUgRGVwYXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5LCBNYXJpYSBDZWNpbGlh
IEhvc3BpdGFsLCBHVk0gQ2FyZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9sYSwgSXRhbHkgKEMuUC4s
IEcuVi4sIEYuTS4sIE0uUy4sIE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4sIEIuSS4sIEEuUC4sIFIu
Vi4sIEEuQy4sIFouQy4sIE0uTS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xpbmljYWwgQ2FyZGlvbG9n
eSwgVW5pdmVyc2l0YSBkZWwgUGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5vdmFyYSwgSXRhbHkgKEEu
Ri4pJiN4QTtGcm9tIHRoZSBEZXBhcnRtZW50IG9mIEFycmh5dGhtb2xvZ3ksIE1hcmlhIENlY2ls
aWEgSG9zcGl0YWwsIEdWTSBDYXJlIGFuZCBSZXNlYXJjaCwgQ290aWdub2xhLCBJdGFseSAoQy5Q
LiwgRy5WLiwgRi5NLiwgTS5TLiwgTS5CLiwgQS5QLiwgQy5DLiwgTC5HLiwgQi5JLiwgQS5QLiwg
Ui5WLiwgQS5DLiwgWi5DLiwgTS5NLiwgTC5ULiwgVi5TLik7IGFuZCBDbGluaWNhbCBDYXJkaW9s
b2d5LCBVbml2ZXJzaXRhIGRlbCBQaWVtb250ZSBBLiBBdm9nYWRybywgTm92YXJhLCBJdGFseSAo
QS5GLikmI3hBO0Zyb20gdGhlIERlcGFydG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFyaWEgQ2Vj
aWxpYSBIb3NwaXRhbCwgR1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0YWx5IChD
LlAuLCBHLlYuLCBGLk0uLCBNLlMuLCBNLkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkkuLCBBLlAu
LCBSLlYuLCBBLkMuLCBaLkMuLCBNLk0uLCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2FsIENhcmRp
b2xvZ3ksIFVuaXZlcnNpdGEgZGVsIFBpZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEsIEl0YWx5
IChBLkYuKSYjeEE7RnJvbSB0aGUgRGVwYXJ0bWVudCBvZiBBcnJoeXRobW9sb2d5LCBNYXJpYSBD
ZWNpbGlhIEhvc3BpdGFsLCBHVk0gQ2FyZSBhbmQgUmVzZWFyY2gsIENvdGlnbm9sYSwgSXRhbHkg
KEMuUC4sIEcuVi4sIEYuTS4sIE0uUy4sIE0uQi4sIEEuUC4sIEMuQy4sIEwuRy4sIEIuSS4sIEEu
UC4sIFIuVi4sIEEuQy4sIFouQy4sIE0uTS4sIEwuVC4sIFYuUy4pOyBhbmQgQ2xpbmljYWwgQ2Fy
ZGlvbG9neSwgVW5pdmVyc2l0YSBkZWwgUGllbW9udGUgQS4gQXZvZ2Fkcm8sIE5vdmFyYSwgSXRh
bHkgKEEuRi4pJiN4QTtGcm9tIHRoZSBEZXBhcnRtZW50IG9mIEFycmh5dGhtb2xvZ3ksIE1hcmlh
IENlY2lsaWEgSG9zcGl0YWwsIEdWTSBDYXJlIGFuZCBSZXNlYXJjaCwgQ290aWdub2xhLCBJdGFs
eSAoQy5QLiwgRy5WLiwgRi5NLiwgTS5TLiwgTS5CLiwgQS5QLiwgQy5DLiwgTC5HLiwgQi5JLiwg
QS5QLiwgUi5WLiwgQS5DLiwgWi5DLiwgTS5NLiwgTC5ULiwgVi5TLik7IGFuZCBDbGluaWNhbCBD
YXJkaW9sb2d5LCBVbml2ZXJzaXRhIGRlbCBQaWVtb250ZSBBLiBBdm9nYWRybywgTm92YXJhLCBJ
dGFseSAoQS5GLikmI3hBO0Zyb20gdGhlIERlcGFydG1lbnQgb2YgQXJyaHl0aG1vbG9neSwgTWFy
aWEgQ2VjaWxpYSBIb3NwaXRhbCwgR1ZNIENhcmUgYW5kIFJlc2VhcmNoLCBDb3RpZ25vbGEsIEl0
YWx5IChDLlAuLCBHLlYuLCBGLk0uLCBNLlMuLCBNLkIuLCBBLlAuLCBDLkMuLCBMLkcuLCBCLkku
LCBBLlAuLCBSLlYuLCBBLkMuLCBaLkMuLCBNLk0uLCBMLlQuLCBWLlMuKTsgYW5kIENsaW5pY2Fs
IENhcmRpb2xvZ3ksIFVuaXZlcnNpdGEgZGVsIFBpZW1vbnRlIEEuIEF2b2dhZHJvLCBOb3ZhcmEs
IEl0YWx5IChBLkYuKTwvQWRkcmVzcz48V2ViX1VSTD5QTToyNTA1MjQwNTwvV2ViX1VSTD48Wlpf
Sm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkNpcmN1bGF0aW9uPC9mPjwvWlpfSm91
cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0
ZT48L1JlZm1hbj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405Prospective single center registry of WPW pts 2169 ptsAll pts w/ a manifest AP underwent EP±RF. Followed 8 yBoth asymptomatic and symptomatic pts studied at EP to identify risk factors for VF1001 pts (550 asymptomatic) did not undergo RF and 1168 (550 asymptomatic) underwent RF. F/u of 8 y. VF occurred in 1.5% of the no-RF group (mean age 11 y) and no VF occurred in the RF treated group (p<0.001). VF was associated w/ a short ERP of the AP w/ an optimal cut-off of 240 msec (p<0.001) and AVRT initiating AF (p<0.001).Large single center registry showing that EP findings identified pts w/ a manifest AP at high risk for VF and the risk was eliminated w/ ablation.AAD indicates antiarrhythmic drugs; ACLS, Advanced Cardiovascular Life Support; AF, atrial fibrillation; AHA, American Heart Association; AP, accessory pathway; AT, atrial tachycardia; AV, atrioventricular; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; bpm, beats per min; CAF, chronic atrial fibrillation; CHF, congestive heart failure; CL, cycle length; EP, electrophysiological; ERP, effective refractory period; f/u, follow up; h/o, history of; IV, intravenous; MI, myocardial infarction; N/A, not applicable; NPV, negative predictive value; PAF, paroxysmal atrial fibrillation; PPV, positive predictive value; PSVT, paroxysmal supraventricular tachycardia; pt, patient; FR, radiofrequency; RVR, rapid ventricular response; SVT, supraventricular tachycardia; sx, symptom; TIA, transient ischemic attack; VF, ventricular fibrillation; w/, with; w/o, without; and WPW, Wolff–Parkinson-White syndrome. Data Supplement 13. Summary of Included Studies – ERC Report (Section 6.2)Study (Author, Year)Study DesignSample Size (N)Participant CharacteristicsInclusion CriteriaExclusion CriteriaMilstein S1986 ADDIN REFMGR.CITE <Refman><Cite><Author>Milstein</Author><Year>1986</Year><RecNum>514</RecNum><IDText>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>514</Ref_ID><Title_Primary>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Milstein,S.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Date_Primary>1986/5/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Rest</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1097</Start_Page><End_Page>1100</End_Page><Periodical>Am J Cardiol</Periodical><Volume>57</Volume><Issue>13</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(86)90681-8</Misc_3><Web_URL>PM:3706161</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(171)3706161Uncontrolled prospective cohort study. All pts underwent an EP study.42Mean age (±SD) 36 y (±12 y); age range 7-77 yGender: 21 (50%) men and 21 (50%) women SHD: --- WPW pattern seen on a routine ECG. These pts were considered asymptomatic because they had neither documented arrhythmias nor a h/o sustained palpitations ---Satoh M1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Satoh</Author><Year>1989</Year><RecNum>515</RecNum><IDText>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>515</Ref_ID><Title_Primary>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Satoh,M.</Authors_Primary><Authors_Primary>Aizawa,Y.</Authors_Primary><Authors_Primary>Funazaki,T.</Authors_Primary><Authors_Primary>Niwano,S.</Authors_Primary><Authors_Primary>Ebe,K.</Authors_Primary><Authors_Primary>Miyajima,S.</Authors_Primary><Authors_Primary>Suzuki,K.</Authors_Primary><Authors_Primary>Aizawa,M.</Authors_Primary><Authors_Primary>Shibata,A.</Authors_Primary><Date_Primary>1989/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>diagnostic use</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>413</Start_Page><End_Page>420</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>12</Volume><Issue>3</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>First Department of Internal Medicine, Niigata University School of Medicine, Japan</Address><Web_URL>PM:2466266</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(172)2466266Uncontrolled observational cohort study. All pts underwent an EP study.95 (34 asymptomatic and 61 symptomatic pts)Mean age (± SD) 32 y (± 19 y)Male 73%SHD 13%Intermittent preexcitation 23%WPW patternAsymptomatic (neither documented tachycardia, nor a h/o palpitations suggestive of paroxysmal tachycardia.)---Klein GJ1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Klein</Author><Year>1989</Year><RecNum>512</RecNum><IDText>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>512</Ref_ID><Title_Primary>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</Title_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Date_Primary>1989/5/11</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Longitudinal Studies</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Refractory Period,Electrophysiological</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1229</Start_Page><End_Page>1233</End_Page><Periodical>N.Engl.J Med</Periodical><Volume>320</Volume><Issue>19</Issue><ISSN_ISBN>0028-4793</ISSN_ISBN><Misc_3>10.1056/NEJM198905113201901</Misc_3><Address>Clinical Electrophysiology Laboratory, University Hospital, London, ON, Canada</Address><Web_URL>PM:2710202</Web_URL><ZZ_JournalFull><f name="System">The New England journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">N.Engl.J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(173)2710202Uncontrolled prospective observational study. All pts underwent an EP study.29Age (±SD): 50 y (±18 y) in the preexcitation lost subgroup39 y (±11 y) in the preexcitation persistent subgroupGender: 17/29 (58.6%) men, 12/29 (41.4%) womenSHD: ---Asymptomatic WPW ECG patternNo documented tachycardia and no h/o sustained tachycardia. ---Leitch JW1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Leitch</Author><Year>1990</Year><RecNum>513</RecNum><IDText>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>513</Ref_ID><Title_Primary>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Leitch,J.W.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Murdock,C.</Authors_Primary><Date_Primary>1990/11</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Models,Statistical</Keywords><Keywords>mortality</Keywords><Keywords>Ontario</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1718</Start_Page><End_Page>1723</End_Page><Periodical>Circulation</Periodical><Volume>82</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University Hospital, London, Ontario, Canada</Address><Web_URL>PM:2225373</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(174)2225373Uncontrolled prospective observational study. All pts underwent an EP study.75Mean age (± SD) 34 y (± 13 y), age range 7-77 yMale 44 (59%)SHD 5/75 (7%): (1 w/ CAD, 2 w/ cardiomyopathy, 1 w/ VHD, 1 w/ Ebstein’s anomaly) Asymptomatic w/ WPW ECG patternAll pts underwent sx-limited exercise stress testing and 24-h Holter monitoring and were excluded from the study if SVT was documented at any time. Other specific exclusions were intermittent preexcitation either at rest or during exercise testing and EP study. Brembilla-Perrot B2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN EN.CITE.DATA (175)11707045Uncontrolled prospective observational study. All pts underwent testing w/ transesophageal stimulation.92Mean age (±SD): 34 y (±15 y), age range 11-69 y68 men, 24 womenNo SHDAsymptomatic WPW ECG patternNo documented tachycardia and no h/o sustained tachycardia Documentation of SVT at any timePappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (176)12535816Uncontrolled prospective observational study. All pts underwent an EP study.212Mean age of overall population (± SD): 35.8 y (± 20.5 y), age range 7-63 y. Gender in overall population: N/A. SHD in overall population was present in 10/212 (5%) (5 w/ MVP, 2 w/ HCM, 3 w/ hypertension)Mean age (±SD) of the 162 pts w/ complete f/u 33.6 y (±14.3 y), age range 7-63 y. Male 105/162 (65%). SHD was present in 4/162 (3 w/ MVP, 1 w/ HCM) Asymptomatic WPW pattern was found either incidentally at routine examination or during a medical check-up before admission to a competitive sport or a high-risk occupation---Pappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (177)14602878Combined RCT and prospective observational cohort study. All pts underwent EP study. Pts w/ inducible arrhythmia on EP study who were ≤35 y were randomized to ablation vs. no ablation. The remaining pts were followed as an observational cohort.224 (EP study identified 76 high-risk pts who were then enrolled in a RCT and 148 low-risk pts enrolled in a prospective observational cohort study)Median (IQR) age 23 y (15-30 y) for ablation group and 22 y (15-30 y) for no ablation group. Male sex 53% in ablation arm and 47% in no ablation group. No SHD in either group. Median (IQR) age for observational cohort 36 y (27-48 y). Male sex 59% in this cohort. SHD 7%.Ventricular preexcitation documented by 12-lead ECGAbsence of arrhythmia-related sxsParticipation in other investigational protocolsAge <13 yPregnancyConcomitant medical conditionsSantinelli V2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (178)19808453Uncontrolled prospective observational study. All pts underwent an EP study293 Median age (IQR) 36 y (28-48 y)Male 61%Incidental WPW pattern on ECGAsymptomatic based on an accurate historyParticipation in other research studiesPappone C2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405Uncontrolled prospective observational study. All pts underwent an EP study. They reported data by treatment w/ catheter ablation.2169 (756 asymptomatic and 550 asymptomatic and w/ no ablation and 1413 symptomatic pts)Median age 19 y, male preponderance among asymptomatic pts (63%).SHDs were found in 1.5% of asymptomatic ptsAsymptomatic and symptomatic pts w/o prior ablation or documented life-threatening arrhythmias who consented to undergo a baseline EP study---CAD indicates coronary artery disease; ECG, electrocardiogram; EP, electophysiological; HCM, hypertrophic cardiomyopathy; IQR, interquartile range; MVP, mitral valve prolapse; N/A, not applicable; pt, patient; RCT, randomized controlled trial; SD, standard deviation; SHD, structural heart disease; SVT, supraventricular tachycardia; sx, symptom; VHD, valvular heart disease; w/, with; w/o, without; WPW, Wolff-Parkinson-White syndrome; and ---, not available. Data Supplement 14. Comparators and Outcomes – ERC Report (Section 6.2)Study (Author, Year)Study GroupsResults of Noninvasive TestingResults of Invasive EP StudyAcute Outcome of Catheter AblationClinical Outcomes of InterestDuration of F/uLoss to F/uMilstein S1986 ADDIN REFMGR.CITE <Refman><Cite><Author>Milstein</Author><Year>1986</Year><RecNum>514</RecNum><IDText>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>514</Ref_ID><Title_Primary>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Milstein,S.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Date_Primary>1986/5/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Rest</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1097</Start_Page><End_Page>1100</End_Page><Periodical>Am J Cardiol</Periodical><Volume>57</Volume><Issue>13</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(86)90681-8</Misc_3><Web_URL>PM:3706161</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(171)3706161Group 1: Asymptomatic WPW patternN/A43 APs in 42 asymptomatic pts. Mean ERP of AP was 333±106 msec in asymptomatic pts vs. 298± 42 msec in asymptomatic pts (p<0.025). Mean shortest RR interval during AF 277±48 msec in the asymptomatic groups vs. 247±51 msec in the symptomatic group (p<0.025). Sustained AVRT could be induced in only 1 pt. No ablation1 pt died of metastatic carcinoma after 43 mo, 1 pt died suddenly after he had agreed to participate in the study but before EP study could be performed. 4 pts received propranolol because of undocumented "skipped beats." All other pts remained asymptomatic.29±18 moNoneKlein GJ1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Klein</Author><Year>1989</Year><RecNum>512</RecNum><IDText>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>512</Ref_ID><Title_Primary>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</Title_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Date_Primary>1989/5/11</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Longitudinal Studies</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Refractory Period,Electrophysiological</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1229</Start_Page><End_Page>1233</End_Page><Periodical>N.Engl.J Med</Periodical><Volume>320</Volume><Issue>19</Issue><ISSN_ISBN>0028-4793</ISSN_ISBN><Misc_3>10.1056/NEJM198905113201901</Misc_3><Address>Clinical Electrophysiology Laboratory, University Hospital, London, ON, Canada</Address><Web_URL>PM:2710202</Web_URL><ZZ_JournalFull><f name="System">The New England journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">N.Engl.J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(173)2710202Group 1: Invasive EP study w/o catheter ablationN/A28/29 (97%) pts had only 1 AP and 1/29 (3%) pts had more than 1 AP. The mean (± SD) ERP of pathway(s) at baseline 334 msec (±105 msec) on the initial study and 301 msec (±78 msec) on the f/u study. The shortest RR interval (±SD) during induced AF was 266 msec (±39 msec). Sustained AF was induced in 2/29 (7%) pts on the initial study and 11/29 (38%) pts on the f/u study. No ablationSustained PSVT 2/29 (7%) (during 36-79 mo); 27/29 (93%) remained asymptomatic;9/29 (31%) lost WPW pattern on ECG.36-79 mo NoneSatoh M1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Satoh</Author><Year>1989</Year><RecNum>515</RecNum><IDText>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>515</Ref_ID><Title_Primary>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Satoh,M.</Authors_Primary><Authors_Primary>Aizawa,Y.</Authors_Primary><Authors_Primary>Funazaki,T.</Authors_Primary><Authors_Primary>Niwano,S.</Authors_Primary><Authors_Primary>Ebe,K.</Authors_Primary><Authors_Primary>Miyajima,S.</Authors_Primary><Authors_Primary>Suzuki,K.</Authors_Primary><Authors_Primary>Aizawa,M.</Authors_Primary><Authors_Primary>Shibata,A.</Authors_Primary><Date_Primary>1989/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>diagnostic use</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>413</Start_Page><End_Page>420</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>12</Volume><Issue>3</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>First Department of Internal Medicine, Niigata University School of Medicine, Japan</Address><Web_URL>PM:2466266</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(172)2466266Group 1: Asymptomatic pts w/ WPW patternIntermittent preexcitation on ECG recording 23%Number of pts w/ multiple APs not reported. Baseline mean ERP of AP was 288±29 msec in asymptomatic pts. Shortest RR in AF not reported. AVRT induced in 6/34 (18%) pts in the asymptomatic group, sustained AF was induced in 2/34 (6%) of asymptomatic pts. No ablationGroup 1: no eventsGroup 2: 2 pts w/ symptomatic WPW syndrome had VF and were resuscitated successfully Mean 15 mo (range 2 to 47 mo)---Leitch JW1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Leitch</Author><Year>1990</Year><RecNum>513</RecNum><IDText>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>513</Ref_ID><Title_Primary>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Leitch,J.W.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Murdock,C.</Authors_Primary><Date_Primary>1990/11</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Models,Statistical</Keywords><Keywords>mortality</Keywords><Keywords>Ontario</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1718</Start_Page><End_Page>1723</End_Page><Periodical>Circulation</Periodical><Volume>82</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University Hospital, London, Ontario, Canada</Address><Web_URL>PM:2225373</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(174)2225373Group 1: Invasive EP study w/o catheter ablationN/AAt baseline, the median ERP of the AP was 293 msec (IQR 280-310 msec), and the median retrograde ERP of the AP was 288 msec (IQR 240-320 msec).The median shortest RR interval during preexcited AF was 274 msec (IQR 240-325 msec) in 72 pts, was ≤250 msec in 23 pts and was ≤200 msec in 8 pts.AVRT was induced in 12/75 (16%) and sustained AF was induced in 23/75 (31%). No ablation3/75 (4%) died of noncardiac causes, 1/75 (1%) pt died suddenly after initial consultation but before EP study was done. 5/75 (7%) developed symptomatic AVRT. 1/75 (1%) developed symptomatic AF. The presence of sustained AVRT at EP study did not differentiate pts who remained asymptomatic from pts who became symptomatic. Only 1 (4%) pt developed clinical AF of the 23 pts in whom AF was induced at EP study. Median 4.3 y (range 1-9 y)NoneBrembilla-Perrot B2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN EN.CITE.DATA (175)11707045Group 1: Transesophageal stimulation All pts had 24-h Holter and stress test performed prior to study entry and only those w/o supraventricular arrhythmia were includedThe number of APs found was not reported. The ERP of pathway(s) at baseline and during isoproterenol infusion were not reported. Shortest RR interval (<250 msec) during induced AF was present in 20/92 (22%) pts. Atrial tachyarrhythmia was induced in 27% of pts.No ablation3/92 (3%) pts developed symptomatic AF several y later. Of these 3 pts, 1 presented w/ AF and then VF 1 d after an aortic aneursymectomy. Among the 42 pts considered to have a benign form of WPW syndrome, there was no clinical event, except a death related to an accident.--- ---Pappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (176)12535816Group 1: Invasive EP study w/o catheter ablationN/A17/162 (10%) had multiple APs. Baseline mean (± SD) ERP 275.2 msec (± 33.8 msec). Isoproterenol mean (± SD) ERP 246.1 msec (± 30.5 msec). Shortest RR in AF not reported47/162 (29%) had inducible arrhythmia: nonsustained AF in 17, sustained AF in 19, inducible AVRT that degenerated into totally preexcited sustained AF in 11.No ablation129/209 (62%) remained asymptomatic at the end of follow- up, whereas 33 (16%) developed arrhythmic events: SVT in 25, AF in 8, documented VF in 3/209 (aborted sudden death in 2 (both had developed sxs due to AF) and sudden death in 1/209) 37.7±16.1 mo; range 14 to 60 mo 3/212 (1.4%) 47/212 who ref/used the 5-y EP study were excluded from the analysisPappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (177)14602878Group 1: AblationGroup 2: No ablationGroup 3: Low-risk group followed as an observational cohortN/A15/37 (41%) pts in the ablation group had inducible AVRT. In 8 additional pts, AVRT degenerated into sustained AF.The median number of RF applications was 9 (range, 5 to 22). Ablation was acutely successful in all pts. Complications related to EP study (2 pneumothoraxes and 1 large femoral hematoma) developed in 3 (1%) pts. An ablation-related complication (permanent right bundle-branch block) developed in 1/37 (3%) pt w/ an anteroseptal AP.2/37 (5%) pts in the ablation group had an arrhythmic event found on EP study to be due to AVNRT in both pts. W/in a mean of 15 mo, 21/35 (60%) pts in the no ablation group had an arrhythmic event which was SVT in 15 pts, AF in 5 pts, and VF (not preceded by sxs) in 1 pt. Among the high-risk controls (group 2), the 5-y rate of arrhythmic events was 77% vs. 7% in the ablation group. In the observational cohort, sxs of SVT developed in 6 pts and 20 pts lost ventricular preexcitation. Ablation group median f/u 27 mo, range 9-60 mo. Control group median f/u 21 mo, range 8-60 mo.NoneSantinelli V2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (178)19808453Group 1: Invasive EP study w/o catheter ablationN/AAnterograde ERP of AP ≤250 msec was present in 39/293 (13%) pts.Multiple APs were found in 13 (4%) pts.Inducible arrhythmia was found in 47 (16%) pts.No ablation262/293 (89%) pts did not experience arrhythmic events, remaining totally asymptomatic, whereas 31/293 (11%) pts had an arrhythmic event, which was potentially life-threatening in 17 of them. Potentially life-threatening tachyarrhythmias resulted in resuscitated cardiac arrest (1 pt), presyncope (7 pts), syncope (4 pts), or dizziness (5 pts).Median duration of f/u after EP study was 67 mo (range 8 to 90)---Pappone C2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405Group 1: Asymptomatic pts w/ WPW pattern (they presented data on symptomatic pts and by whether or not catheter ablation of the AP was done), but the groups were not matched and selection bias was not adjusted for)---No ablation: Multiple APs in 59 (6%), median (IQR) ERP of AP 280 msec (250-300 msec). Inducible AVRT triggering AF on EP study was found in 47 (5%) of pts. W/ Ablation:Multiple APs in 80 (7%), median ERP (IQR) of AP 280 msec (250-300 msec). Inducible AVRT triggering AF on EP study was found in 73 (6%) of pts.206/756 asymptomatic pts were treated w/ ablation; ablation was successful in 98.5%.No ablation: during a median f/u of 22 mo VF occurred in 13/550 (2%) asymptomatic pts (almost exclusively in children). During a median f/u of 46.5 mo, 48/550 (9%) additional asymptomatic pts experienced malignant arrhythmias 86/756 (11%) of the asymptomatic pts developed benign arrhythmias (AVRT and AF).W/ ablation: no pt developed malignant arrhythmias or VF over the 8 y of f/u.Median 96 moNo ablation: completeness of f/u was 99.8% at 1 y and 92.3% at the end of the studyW/ ablation: completeness of f/u was 95.5% at 1 y and 90.2% at the end of the studyAF indicates atrial fibrillation; AP, accessory pathway; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventrial reentrant tachycardia; ECG, echocardiogram; EP, electrophysiological; ERP, effective refractory period; f/u, follow up; IQR, interquartile range; N/A, not applicable; pt, patient; RF, radiofrequency; SD, standard deviation; SVT, supraventricular tachycardia; VF, ventricular fibrillation; w/, with; w/o, without; WPW, Wolf-Parkinson-White syndrome; and ---, not available. Data Supplement 15. Quality Assesment of Included Studies – ERC Report (Section 6.2)Study (Author, Year)Representativeness of the CohortSelection of a Nonexposed CohortAscertainment of ExposureDemonstration that Outcome of Interest was not Present at EnrollmentIndependent Blind Assessment of OutcomesWas Follow Up Long Enough for Outcomes to Occur?Adequacy of Follow Up of Cohort (Including Loss to Follow Up)Precision of FindingsMilstein S1986 ADDIN REFMGR.CITE <Refman><Cite><Author>Milstein</Author><Year>1986</Year><RecNum>514</RecNum><IDText>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>514</Ref_ID><Title_Primary>Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Milstein,S.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Date_Primary>1986/5/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Rest</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1097</Start_Page><End_Page>1100</End_Page><Periodical>Am J Cardiol</Periodical><Volume>57</Volume><Issue>13</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(86)90681-8</Misc_3><Web_URL>PM:3706161</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(171)3706161YesN/A (all pts underwent EP study)All pts underwent EP studyYes---YesYesImprecise due to small sample sizeKlein GJ1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Klein</Author><Year>1989</Year><RecNum>512</RecNum><IDText>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>512</Ref_ID><Title_Primary>Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern</Title_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Sharma,A.D.</Authors_Primary><Date_Primary>1989/5/11</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Longitudinal Studies</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Refractory Period,Electrophysiological</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1229</Start_Page><End_Page>1233</End_Page><Periodical>N.Engl.J Med</Periodical><Volume>320</Volume><Issue>19</Issue><ISSN_ISBN>0028-4793</ISSN_ISBN><Misc_3>10.1056/NEJM198905113201901</Misc_3><Address>Clinical Electrophysiology Laboratory, University Hospital, London, ON, Canada</Address><Web_URL>PM:2710202</Web_URL><ZZ_JournalFull><f name="System">The New England journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">N.Engl.J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(173)2710202YesN/A (no comparator group)All pts underwent EP study2/29 had SVT between scheduling EP study and when EP study was performed---YesYesN/A (no comparator group)Satoh M1989 ADDIN REFMGR.CITE <Refman><Cite><Author>Satoh</Author><Year>1989</Year><RecNum>515</RecNum><IDText>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>515</Ref_ID><Title_Primary>Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Satoh,M.</Authors_Primary><Authors_Primary>Aizawa,Y.</Authors_Primary><Authors_Primary>Funazaki,T.</Authors_Primary><Authors_Primary>Niwano,S.</Authors_Primary><Authors_Primary>Ebe,K.</Authors_Primary><Authors_Primary>Miyajima,S.</Authors_Primary><Authors_Primary>Suzuki,K.</Authors_Primary><Authors_Primary>Aizawa,M.</Authors_Primary><Authors_Primary>Shibata,A.</Authors_Primary><Date_Primary>1989/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>diagnostic use</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>413</Start_Page><End_Page>420</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>12</Volume><Issue>3</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>First Department of Internal Medicine, Niigata University School of Medicine, Japan</Address><Web_URL>PM:2466266</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(172)2466266YesN/A (all pts underwent EP study)All pts underwent EP studyYes---Yes---Imprecise (no events)Leitch JW1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Leitch</Author><Year>1990</Year><RecNum>513</RecNum><IDText>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>513</Ref_ID><Title_Primary>Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern</Title_Primary><Authors_Primary>Leitch,J.W.</Authors_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Yee,R.</Authors_Primary><Authors_Primary>Murdock,C.</Authors_Primary><Date_Primary>1990/11</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Canada</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>London</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Models,Statistical</Keywords><Keywords>mortality</Keywords><Keywords>Ontario</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1718</Start_Page><End_Page>1723</End_Page><Periodical>Circulation</Periodical><Volume>82</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University Hospital, London, Ontario, Canada</Address><Web_URL>PM:2225373</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(174)2225373QuestionableN/A (no comparator group)All pts underwent EP studyYes---YesYesN/A (no comparator group)Brembilla-Perrot B2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDAx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ADDIN EN.CITE.DATA (175)11707045YesN/A (no comparator group)All pts underwent EP studyReasonable based on the absence of sxs. Pts had to have a normal ECG, exercise stress test and 24-h Holter monitor---Uncertain as duration of f/u was not reportedF/u and loss to f/u were not reportedN/A (no comparator group)Pappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
ZWNOdW0+NTEwPC9SZWNOdW0+PElEVGV4dD5Vc2VmdWxuZXNzIG9mIGludmFzaXZlIGVsZWN0cm9w
aHlzaW9sb2dpYyB0ZXN0aW5nIHRvIHN0cmF0aWZ5IHRoZSByaXNrIG9mIGFycmh5dGhtaWMgZXZl
bnRzIGluIGFzeW1wdG9tYXRpYyBwYXRpZW50cyB3aXRoIFdvbGZmLVBhcmtpbnNvbi1XaGl0ZSBw
YXR0ZXJuOiByZXN1bHRzIGZyb20gYSBsYXJnZSBwcm9zcGVjdGl2ZSBsb25nLXRlcm0gZm9sbG93
LXVwIHN0dWR5PC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJu
YWw8L1JlZl9UeXBlPjxSZWZfSUQ+NTEwPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+VXNlZnVsbmVz
cyBvZiBpbnZhc2l2ZSBlbGVjdHJvcGh5c2lvbG9naWMgdGVzdGluZyB0byBzdHJhdGlmeSB0aGUg
cmlzayBvZiBhcnJoeXRobWljIGV2ZW50cyBpbiBhc3ltcHRvbWF0aWMgcGF0aWVudHMgd2l0aCBX
b2xmZi1QYXJraW5zb24tV2hpdGUgcGF0dGVybjogcmVzdWx0cyBmcm9tIGEgbGFyZ2UgcHJvc3Bl
Y3RpdmUgbG9uZy10ZXJtIGZvbGxvdy11cCBzdHVkeTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PlBhcHBvbmUsQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNhbnRp
bmVsbGksVi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJvc2FuaW8sUy48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlZpY2Vkb21pbmksRy48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5Pk5hcmRpLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5QYXBwb25lLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Ub3J0
b3JpZWxsbyxWLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWFuZ3VzbyxGLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWF6em9uZSxQLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+R3VsbGV0dGEsUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5Pk9yZXRvLEcuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BbGZp
ZXJpLE8uPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDAzLzEvMTU8L0RhdGVfUHJp
bWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3
b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNh
cmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPmNv
bXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNp
b2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwvS2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9waHlz
aW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+ZXRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5G
ZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb2xsb3ctVXAgU3R1ZGllczwvS2V5d29yZHM+PEtl
eXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5z
PC9LZXl3b3Jkcz48S2V5d29yZHM+SXRhbHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3
b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9L
ZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRo
b2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48
S2V5d29yZHM+UmlzazwvS2V5d29yZHM+PEtleXdvcmRzPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZp
Y2l0eTwvS2V5d29yZHM+PEtleXdvcmRzPlN1cnZpdmFsIEFuYWx5c2lzPC9LZXl3b3Jkcz48S2V5
d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5Xb2xmZi1QYXJraW5zb24tV2hp
dGUgU3luZHJvbWU8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFy
dF9QYWdlPjIzOTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MjQ0PC9FbmRfUGFnZT48UGVyaW9kaWNh
bD5KIEFtIENvbGwgQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjQxPC9Wb2x1bWU+PElzc3Vl
PjI8L0lzc3VlPjxJU1NOX0lTQk4+MDczNS0xMDk3PC9JU1NOX0lTQk4+PE1pc2NfMz5TMDczNTEw
OTcwMjAyNzA2NzwvTWlzY18zPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRWxl
Y3Ryb3BoeXNpb2xvZ3ksIGFuZCBDYXJkaWFjIFBhY2luZyBVbml0LCBTYW4gUmFmZmFlbGUgVW5p
dmVyc2l0eSBIb3NwaXRhbCwgTWlsYW4sIEl0YWx5LiBjYXJsby5wYXBwb25lQGhzci5pdDwvQWRk
cmVzcz48V2ViX1VSTD5QTToxMjUzNTgxNjwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFt
ZT0iU3lzdGVtIj5Kb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBDb2xsZWdlIG9mIENhcmRpb2xvZ3k8
L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0i
PkogQW0gQ29sbCBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1J
RD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS
ZWNOdW0+NTEwPC9SZWNOdW0+PElEVGV4dD5Vc2VmdWxuZXNzIG9mIGludmFzaXZlIGVsZWN0cm9w
aHlzaW9sb2dpYyB0ZXN0aW5nIHRvIHN0cmF0aWZ5IHRoZSByaXNrIG9mIGFycmh5dGhtaWMgZXZl
bnRzIGluIGFzeW1wdG9tYXRpYyBwYXRpZW50cyB3aXRoIFdvbGZmLVBhcmtpbnNvbi1XaGl0ZSBw
YXR0ZXJuOiByZXN1bHRzIGZyb20gYSBsYXJnZSBwcm9zcGVjdGl2ZSBsb25nLXRlcm0gZm9sbG93
LXVwIHN0dWR5PC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJu
YWw8L1JlZl9UeXBlPjxSZWZfSUQ+NTEwPC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+VXNlZnVsbmVz
cyBvZiBpbnZhc2l2ZSBlbGVjdHJvcGh5c2lvbG9naWMgdGVzdGluZyB0byBzdHJhdGlmeSB0aGUg
cmlzayBvZiBhcnJoeXRobWljIGV2ZW50cyBpbiBhc3ltcHRvbWF0aWMgcGF0aWVudHMgd2l0aCBX
b2xmZi1QYXJraW5zb24tV2hpdGUgcGF0dGVybjogcmVzdWx0cyBmcm9tIGEgbGFyZ2UgcHJvc3Bl
Y3RpdmUgbG9uZy10ZXJtIGZvbGxvdy11cCBzdHVkeTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PlBhcHBvbmUsQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNhbnRp
bmVsbGksVi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJvc2FuaW8sUy48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlZpY2Vkb21pbmksRy48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5Pk5hcmRpLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5QYXBwb25lLEEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Ub3J0
b3JpZWxsbyxWLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWFuZ3VzbyxGLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWF6em9uZSxQLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+R3VsbGV0dGEsUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5Pk9yZXRvLEcuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BbGZp
ZXJpLE8uPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDAzLzEvMTU8L0RhdGVfUHJp
bWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3
b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNh
cmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPmNv
bXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNp
b2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwvS2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9waHlz
aW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+ZXRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5G
ZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb2xsb3ctVXAgU3R1ZGllczwvS2V5d29yZHM+PEtl
eXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5z
PC9LZXl3b3Jkcz48S2V5d29yZHM+SXRhbHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3
b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9L
ZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRo
b2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48
S2V5d29yZHM+UmlzazwvS2V5d29yZHM+PEtleXdvcmRzPlNlbnNpdGl2aXR5IGFuZCBTcGVjaWZp
Y2l0eTwvS2V5d29yZHM+PEtleXdvcmRzPlN1cnZpdmFsIEFuYWx5c2lzPC9LZXl3b3Jkcz48S2V5
d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5Xb2xmZi1QYXJraW5zb24tV2hp
dGUgU3luZHJvbWU8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFy
dF9QYWdlPjIzOTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MjQ0PC9FbmRfUGFnZT48UGVyaW9kaWNh
bD5KIEFtIENvbGwgQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjQxPC9Wb2x1bWU+PElzc3Vl
PjI8L0lzc3VlPjxJU1NOX0lTQk4+MDczNS0xMDk3PC9JU1NOX0lTQk4+PE1pc2NfMz5TMDczNTEw
OTcwMjAyNzA2NzwvTWlzY18zPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgRWxl
Y3Ryb3BoeXNpb2xvZ3ksIGFuZCBDYXJkaWFjIFBhY2luZyBVbml0LCBTYW4gUmFmZmFlbGUgVW5p
dmVyc2l0eSBIb3NwaXRhbCwgTWlsYW4sIEl0YWx5LiBjYXJsby5wYXBwb25lQGhzci5pdDwvQWRk
cmVzcz48V2ViX1VSTD5QTToxMjUzNTgxNjwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFt
ZT0iU3lzdGVtIj5Kb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBDb2xsZWdlIG9mIENhcmRpb2xvZ3k8
L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0i
PkogQW0gQ29sbCBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1J
RD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN EN.CITE.DATA (176)12535816QuestionableN/A (no comparator group)All pts underwent EP studyYes---YesQuestionableN/A (no comparator group)Pappone C2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (177)14602878QuestionableYes YesReasonable based on the absence of sxsThe events were reviewed by an independent committee whose members were unaware of the pts' treatment assignmentsYesYesFairly precise w/ 95% CI: 0.02-0.33 for arrhythmic events and 95% CI: 0.002-0.104 for event-free survivalSantinelli V2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (178)19808453QuestionableN/A (no comparator group)All pts underwent EP studyYes---Yes---N/A (no comparator group)Pappone C2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405QuestionableN/A (no comparator group)All pts underwent EP studyYes---Yes---N/A (no comparator group)CI indicates confidence intervals; ECG, echocardiogram; EP, electrophysiological; f/u, f/u; N/A, not applicable; pt, patient; SVT, supraventricular tachycardia; sx, symptom; w/, with; and ---, not available.Data Supplement 16. Randomized Trials Comparing Atrial Flutter – Section 7 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsPlatia EV1989PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBsYXRpYTwvQXV0aG9yPjxZZWFyPjE5ODk8L1llYXI+PFJl
Y051bT4yMjY8L1JlY051bT48SURUZXh0PkVzbW9sb2wgdmVyc3VzIHZlcmFwYW1pbCBpbiB0aGUg
YWN1dGUgdHJlYXRtZW50IG9mIGF0cmlhbCBmaWJyaWxsYXRpb24gb3IgYXRyaWFsIGZsdXR0ZXI8
L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5
cGU+PFJlZl9JRD4yMjY8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5Fc21vbG9sIHZlcnN1cyB2ZXJh
cGFtaWwgaW4gdGhlIGFjdXRlIHRyZWF0bWVudCBvZiBhdHJpYWwgZmlicmlsbGF0aW9uIG9yIGF0
cmlhbCBmbHV0dGVyPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+UGxhdGlhLEUuVi48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pk1pY2hlbHNvbixFLkwuPC9BdXRob3Jz
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Qb3J0ZXJmaWVsZCxKLksuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5EYXMsRy48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5
PjE5ODkvNC8xNTwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZHJlbmVyZ2ljIGJldGEtQW50YWdv
bmlzdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPmFkdmVy
c2UgZWZmZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5B
dHJpYWwgRmlicmlsbGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZsdXR0ZXI8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5CbG9vZCBQcmVzc3VyZTwvS2V5d29yZHM+PEtleXdvcmRzPkNsaW5p
Y2FsIFRyaWFscyBhcyBUb3BpYzwvS2V5d29yZHM+PEtleXdvcmRzPkRpZ294aW48L0tleXdvcmRz
PjxLZXl3b3Jkcz5kcnVnIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8
L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5
d29yZHM+PEtleXdvcmRzPkhlYXJ0IFJhdGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5IeXBvdGVuc2lvbjwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPk11bHRpY2Vu
dGVyIFN0dWRpZXMgYXMgVG9waWM8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5d29y
ZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlByb3Bhbm9s
YW1pbmVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmFuZG9tIEFsbG9jYXRpb248L0tleXdvcmRzPjxL
ZXl3b3Jkcz5SZXNlYXJjaDwvS2V5d29yZHM+PEtleXdvcmRzPlNhZmV0eTwvS2V5d29yZHM+PEtl
eXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+PEtleXdvcmRzPlZlcmFwYW1pbDwvS2V5
d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+OTI1PC9TdGFy
dF9QYWdlPjxFbmRfUGFnZT45Mjk8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFtIEogQ2FyZGlvbDwv
UGVyaW9kaWNhbD48Vm9sdW1lPjYzPC9Wb2x1bWU+PElzc3VlPjEzPC9Jc3N1ZT48SVNTTl9JU0JO
PjAwMDItOTE0OTwvSVNTTl9JU0JOPjxNaXNjXzM+MDAwMi05MTQ5KDg5KTkwMTQxLTA8L01pc2Nf
Mz48QWRkcmVzcz5DYXJkaWFjIEFycmh5dGhtaWEgQ2VudGVyLCBXYXNoaW5ndG9uIEhvc3BpdGFs
IENlbnRlciwgV2FzaGluZ3RvbiwgREMgMjAwMTAtMjkzMTwvQWRkcmVzcz48V2ViX1VSTD5QTToy
NTY0NzI1PC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPlRoZSBBbWVy
aWNhbiBqb3VybmFsIG9mIGNhcmRpb2xvZ3k8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5h
bFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkFtIEogQ2FyZGlvbDwvZj48L1paX0pvdXJuYWxT
dGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9S
ZWZtYW4+
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBsYXRpYTwvQXV0aG9yPjxZZWFyPjE5ODk8L1llYXI+PFJl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ADDIN EN.CITE.DATA (179)2564725The effects of esmolol, an ultrashort-acting beta blocker, and verapamil were compared in controlling ventricular response in 45 pts w/ AF or atrial flutterRandomized, parallel, open-label study. 45 ptsEsmolol (n = 21) Verapamil (n = 24)Pts w/ either new onset (less than 48 h, n = 31) or old onset (greater than 48 h, n = 14) of AF or flutter w/ rapid ventricular rateUncontrolled CHF, SSS w/o pacemaker, h/o intolerance to beta blockers or ca-channel blockers, AMI <3 d, impaired renal and hepatic function, SVT other that AF or atrial flutter, digitalis toxicity, SBP <100 mm Hg unless it was usualDrug efficacy was measured by ventricular rate reduction and conversion to sinus rhythm.HR declined w/ esmolol from 139 to 100 bpm and w/ verapamil from 142 to 97 bpm. 50% of esmolol-treated pts w/ new onset of arrhythmias converted to NSR vs. 12% w/ verapamil.N/AN/AHR decline w/ esmolol (p<0.001); HR decline w/ verapamil (p<0.001).Conversion w/ esmolol vs. verapamil (<0.03).Mild hypotension both groupsSalerno DM1989PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbGVybm88L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbGVybm88L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (180)2650517study evaluates the effectiveness and safety of IV diltiazem for the treatment of AF and atrial flutter.Double-blind, parallel, randomized, placebo-controlled.113 pts w/ AF or fluttIV diltiazem 0.25 mg/kg/2 min followed 15 min later by 0.35 mg/kg/2 min if the first dose was tolerated but ineffective. If a pt did not respond, the code was broken and the pt was allowed to receive open-label diltiazem if placebo had been given.Identical placebo113 pts w/ AF or flutter, a ventricular rate greater than or equal to 120 bpm and systolic BP greater than or equal to 90 mm Hg.Severe HFOf 56 pts, 42 (75%) randomized to receive diltiazem responded to 0.25 mg/kg and 10 of 14 responded to 0.35 mg/kg, for a total response rate of 52 of 56 pts (93%), whereas 7 of 57 pts (12%) responded to placebo.Mild hypotensionN/AResponse to diltiazem vs. placebo (p<0.001)IV diltiazem was rapidly effective for slowing the ventricular response in most pts w/ AF or atrial flutter. BP decreased slightly. Side effects were mild.Van Gelder IC1989PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFy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ADDIN EN.CITE.DATA (181)2511744Efficacy and safety of flecainide acetate in the maintenance of sinus rhythm after electrical cardioversion of chronic AF or atrial flutter.81 ptsN/AN/AChronic AF or flutterAge <16 or >80 y; CHF or angina pectoris > III (NYHA); MI <2 y, flecainide intolerance, BBB, SSS w/o pacemaker, antiarrhythmics, severe systemic diseaseMultiple regression analysis showed New York Heart Association class I for exercise tolerance (p=0.0004) and flecainide treatment (p=0.01) to be the main factors increasing the arrhythmia-free episode. However, Mantel-Cox lifetable analysis did not reveal significant differences between arrhythmia-free survival curves of both treatment groups. In the flecainide-treated group, 9% of pts experienced side effects, mostly related to negative dromotropic effects. The incidence of ventricular proarrhythmia in this group of pts was low.N/AN/AN/A9% of pts treated w/ flecainide had adverse events (e.g,sinus arrest, AV block, rate related LBBB).Moderate doses of flecainide (not >300 mg) recommended after cardioversionSuttrop MJ1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Suttorp</Author><Year>1990</Year><RecNum>232</RecNum><IDText>The value of class IC antiarrhythmic drugs for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>232</Ref_ID><Title_Primary>The value of class IC antiarrhythmic drugs for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm</Title_Primary><Authors_Primary>Suttorp,M.J.</Authors_Primary><Authors_Primary>Kingma,J.H.</Authors_Primary><Authors_Primary>Jessurun,E.R.</Authors_Primary><Authors_Primary>Lie,A.Huen</Authors_Primary><Authors_Primary>van Hemel,N.M.</Authors_Primary><Authors_Primary>Lie,K.I.</Authors_Primary><Date_Primary>1990/12</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Propafenone</Keywords><Keywords>Safety</Keywords><Keywords>Single-Blind Method</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Keywords>Time Factors</Keywords><Reprint>Not in File</Reprint><Start_Page>1722</Start_Page><End_Page>1727</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>16</Volume><Issue>7</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>0735-1097(90)90326-K</Misc_3><Address>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands</Address><Web_URL>PM:2123909</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(182)2123909Cardioversion w meds: Single blind randomized study of IV propafenone (2 mg/kg per 10 min) vs. flecainide (2 mg/kg per 10 min)50 pts w/ AF or atrial flutterAF or flutterGroup A- 20 pts w/ AF treated w/ propafenoneGroup C- 5 pts w/ atrial flutter treated w/ proopafenoneAF or flutterGroup B-20 pts w/ AF treated w/ flecainideGroup D- 5 pts w/ atrial flutter treated w/ flecainideAF or atrial flutter <6 mo w/ ventricular rate >100 bpm at rest w/ no HF signsConduction disturbances more that 1st degree AV block, on class I antiarrythmics, WPW syndrome, SSS, AMI, Hyperthyroidism, cardiac surgery <2 wks, atrial enlargement, w/ AF or atrial flutter w/o appropriate anticoagulants, body weight >100 kgConversion to NSR w/in 1 H11/20 (55%)pts w/ AF treated w/ propafenone 18/20 (90%)pts w/ AF treated w/ flecainide (p<0.02)2/5 (40%) pts w/ atrial flutter treated w/ propafenone1/5 (20%) pts w/ atrial flutter treated w/ flecainide. P=NSQRS lengthening (83±15 to 9920 msec) was observed only in the pts treated w/ flecainide (p<0.001).N/AConversion from AF w/ flecainide vs. propafenone (p<0.02).Conversion from atrial flutter w/ fleainidec vs. propafenone (p=NS).Transient AE flecainide vs. propafenone more common (p<0.001)Flecainide 2 mg/kg in 10 min is more effective than propafenone for conversion of AF to NSR but not for conversion of flutter. Few AE w/ propafenone- may be related to low dose. Ellenbogen KA 1991 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFy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ADDIN EN.CITE.DATA (183)1894861To demonstrate the safety and efficacy of a continuous IV diltiazem infusion for 24 h heart rate control Randomized, double-blind, parallel, placebo-controlled IV diltiazem vs. placeboPlaceboPts >18 y w/ AF or atrial flutter w/ duration >24 h and HR >120 bpm Severe CHF, sinus node dysfunction, 2nd or 3rd degree AV block, WPW syndrome or hypotension Therapeutic response (ventricular response <100 bpm, ≥20% decrease in heart rate from baseline or conversion to NSR 74% vs. 0% N/AN/Ap<0.001IV diltiazem is safe and effective at slowing heart rate in AF or fluttVan Gelder IC1991PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTkxPC9ZZWFy
PjxSZWNOdW0+MjM2PC9SZWNOdW0+PElEVGV4dD5QcmVkaWN0aW9uIG9mIHVuZXZlbnRmdWwgY2Fy
ZGlvdmVyc2lvbiBhbmQgbWFpbnRlbmFuY2Ugb2Ygc2ludXMgcmh5dGhtIGZyb20gZGlyZWN0LWN1
cnJlbnQgZWxlY3RyaWNhbCBjYXJkaW92ZXJzaW9uIG9mIGNocm9uaWMgYXRyaWFsIGZpYnJpbGxh
dGlvbiBhbmQgZmx1dHRlcjwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlw
ZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjIzNjwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PlBy
ZWRpY3Rpb24gb2YgdW5ldmVudGZ1bCBjYXJkaW92ZXJzaW9uIGFuZCBtYWludGVuYW5jZSBvZiBz
aW51cyByaHl0aG0gZnJvbSBkaXJlY3QtY3VycmVudCBlbGVjdHJpY2FsIGNhcmRpb3ZlcnNpb24g
b2YgY2hyb25pYyBhdHJpYWwgZmlicmlsbGF0aW9uIGFuZCBmbHV0dGVyPC9UaXRsZV9QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+VmFuIEdlbGRlcixJLkMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5DcmlqbnMsSC5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
VmFuIEdpbHN0LFcuSC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlZlcndlcixS
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGllLEsuSS48L0F1dGhvcnNfUHJp
bWFyeT48RGF0ZV9QcmltYXJ5PjE5OTEvNy8xPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkdWx0
PC9LZXl3b3Jkcz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQsODAgYW5k
IG92ZXI8L0tleXdvcmRzPjxLZXl3b3Jkcz5hbmFseXNpczwvS2V5d29yZHM+PEtleXdvcmRzPkF0
cmlhbCBGaWJyaWxsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmx1dHRlcjwvS2V5
d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaHJvbmljIERp
c2Vhc2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5EaXNlYXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+RWxl
Y3RyaWMgQ291bnRlcnNob2NrPC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48
S2V5d29yZHM+Rm9sbG93LVVwIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5
d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkxvZ2lzdGljIE1vZGVs
czwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdl
ZDwvS2V5d29yZHM+PEtleXdvcmRzPk1pdHJhbCBWYWx2ZTwvS2V5d29yZHM+PEtleXdvcmRzPk11
bHRpdmFyaWF0ZSBBbmFseXNpczwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jk
cz48S2V5d29yZHM+cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvYmFiaWxp
dHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5Qcm9nbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Qcm9z
cGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVncmVzc2lvbiBBbmFseXNpczwv
S2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxl
PC9SZXByaW50PjxTdGFydF9QYWdlPjQxPC9TdGFydF9QYWdlPjxFbmRfUGFnZT40NjwvRW5kX1Bh
Z2U+PFBlcmlvZGljYWw+QW0gSiBDYXJkaW9sPC9QZXJpb2RpY2FsPjxWb2x1bWU+Njg8L1ZvbHVt
ZT48SXNzdWU+MTwvSXNzdWU+PElTU05fSVNCTj4wMDAyLTkxNDk8L0lTU05fSVNCTj48TWlzY18z
PjAwMDItOTE0OSg5MSk5MDcwNy1SPC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJk
aW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIEdyb25pbmdlbiwgVGhlIE5ldGhlcmxhbmRzPC9B
ZGRyZXNzPjxXZWJfVVJMPlBNOjIwNTg1NTg8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5h
bWU9IlN5c3RlbSI+VGhlIEFtZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvZj48L1paX0pv
dXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+QW0gSiBDYXJk
aW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9y
bUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj5=
ADDIN EN.CITE.DATA (184)2058558Cardioversion: reassess prospectively the immediate and long-term results of direct-current electrical cardioversion in chronic AF or atrial flutter, and to determine factors predicting clinical outcome of the arrhythmia after direct-current cardioversion246 ptsMultivariate analysis to identify factors predicting short- and long-term arrhythmia outcome following DC cardioversionN/AAF or atrial flutterSinus rhythm, unstable HF, cardiogenic shock, severs systemic disease, SSS, AMI, contraindication to anticoagulantsCardioversion successful in 70% of pts w/ AF and in 96% of pts w/ flutter. Stepwise logistic regression analysis revealed that arrhythmia duration, type of arrhythmia and age independently influenced conversion rate. 42 and 36% of pts remained in sinus rhythm during 1 and 2 y, respectively. Multivariate regression analysis revealed that the type of arrhythmia), low precardioversion functional class and the presence of nonrheumatic mitral valve disease independently increased the length of the arrhythmia-free episode. Rheumatic heart disease shortened this period.N/AN/AArrhythmia duration (p<0.001); AF vs. atrial flutter (p<0.02) and age (p<0.05) influenced DCV rates. MVanalysis showed arrhythmia type (p=0.0008), functional class (p=0.002) and presence of nonrheumatic disease (p=0.03) increased arrhythmia free period. Rheumatic heart disease decreased arrhythmia free period (p=0.03)Predictors for successful cardioversion include flutter vs. AF. FC, age and rheumatic heart disease affect cardioversion.Kingma JH1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Kingma</Author><Year>1992</Year><RecNum>222</RecNum><IDText>Acute pharmacologic conversion of atrial fibrillation and flutter: the role of flecainide, propafenone, and verapamil</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>222</Ref_ID><Title_Primary>Acute pharmacologic conversion of atrial fibrillation and flutter: the role of flecainide, propafenone, and verapamil</Title_Primary><Authors_Primary>Kingma,J.H.</Authors_Primary><Authors_Primary>Suttorp,M.J.</Authors_Primary><Date_Primary>1992/8/20</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Propafenone</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>Single-Blind Method</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Keywords>Time Factors</Keywords><Keywords>Verapamil</Keywords><Reprint>Not in File</Reprint><Start_Page>56A</Start_Page><End_Page>60A</End_Page><Periodical>Am J Cardiol</Periodical><Volume>70</Volume><Issue>5</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands</Address><Web_URL>PM:1510000</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(185)1510000Cardioversion w meds: Single-blind randomized study design. Efficacy and safety of IV propafenone (2 mg/kg per 10 min) vs. flecainide (2 mg/kg per 10 min) vs. verapamil 10 mg in 1 min.in pts w/ AF or flutt90 Conversion to NSR w/in 1 hr of start of infusion: First 40: flecainide and verapamil assessedConversion to NSR w/in 1 hr of start of infusion:Second 50: flecainide and propafenone comparedConsecutive pts w/ AF or flutterMore than 1st degree AV block, class I antiarrhtyhmics, WPW syndrome, SSS, AMI, hyperthyroidism, cardiac surgery <2 wk, left atrial enlargement with AF or atrial flutter >2 d w/o appropriate anticoagulants, body weight >100 kgConversion to NSR in: 32/37 (86%) AF w/ flecainide11/20 (55%) AF w/ PPFIn recent onset AF, flecainide conversion 24/25 (96%) vs. 8/14 (57%) propafenone, p<0.05.1/8 (13%) atrial flutter w/ flecainide2/5 (40%) atrial flutter propafenone, p=NSOverall verapamil 1/20 (5%)QRS widening occurred in flecainide-treated pts (83±15 to 99±20 msec; p<0.001), but not after propafenone (83±11 to 86±12 msec).N/ARecent onset AF flecainide more effective than propafenone at conversion ((p<0.05)Flutter conversion no difference in conversion w/ flecainide vs. propafenone (p=NS)Verapamil ineffective.QRS widening more common w/ flecainide than propafenone (p<0.001)Flecainide is more effective than propafenone at converting recent onset AF, but not flutter. Verapamil was not effective at converting AF or atrial flutter w/in 1 hrRoberts SA1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvYmVydHM8L0F1dGhvcj48WWVhcj4xOTkzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvYmVydHM8L0F1dGhvcj48WWVhcj4xOTkzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (186)8362772Clinical effectiveness and cost of digoxin at controlling HR in AF and atrial flutter in prospective , observational study at 18 academic centers115 pts Assessed time to HR control w/ digoxin N/A18 yAF or atrial flutter w/ ventricular rates ≥ 120 BPMNYHA class III, IV, HF, surgery, AMIThe median time to ventricular rate control (i.e., resting ventricular rate <100 bpm, decrease in ventricular rate of >20%, or sinus rhythm) was 11.6 h from the first dose of digoxin for all evaluable pts (n = 105) and 9.5 h for those only receiving digoxin (n = 64). Before ventricular rate control, the mean ±SD dose of digoxin administered was 0.80±0.74 mg, and a mean of 1.4±1.8 serum digoxin concentrations were ordered per pt.N/AN/AN/AObservational studyTucker KJ1993 ADDIN REFMGR.CITE <Refman><Cite><Author>Tucker</Author><Year>1993</Year><RecNum>234</RecNum><IDText>A comparison of transoesophageal atrial pacing and direct current cardioversion for the termination of atrial flutter: a prospective, randomised clinical trial</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>234</Ref_ID><Title_Primary>A comparison of transoesophageal atrial pacing and direct current cardioversion for the termination of atrial flutter: a prospective, randomised clinical trial</Title_Primary><Authors_Primary>Tucker,K.J.</Authors_Primary><Authors_Primary>Wilson,C.</Authors_Primary><Date_Primary>1993/6</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Atrial Function</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Cardiology</Keywords><Keywords>Digoxin</Keywords><Keywords>Electric Countershock</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Block</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiology</Keywords><Keywords>physiopathology</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapy</Keywords><Keywords>United States</Keywords><Reprint>Not in File</Reprint><Start_Page>530</Start_Page><End_Page>535</End_Page><Periodical>Br.Heart J</Periodical><Volume>69</Volume><Issue>6</Issue><User_Def_5>PMC1025166</User_Def_5><ISSN_ISBN>0007-0769</ISSN_ISBN><Address>Department of Medicine, Naval Hospital, Oakland, California</Address><Web_URL>PM:8343321</Web_URL><ZZ_JournalFull><f name="System">British heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Br.Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(187)8343321Pace terminationProspective randomized clinical trial: Comparison of safety and efficacy of transesophageal atrial pacing vs. DC cardioversion in pts on medical therapy.21 consec ptsGroup A- 11 pts treated w/ TAPGroup B- 10 pts treated w/ DC cardioversionConsecutive pts w/ flutter- HD stable. - Had failed 1A or 1C antiarrhythmic therapy-All pts received digoxin to control HR to <100 BPMN/ANSR achieved w/ interventionGroup A- 8/11 TAP ptsGroup B- 9/10 DC cardioversion ptsP= 0.31Nonsustained VT was more frequent in DC cardioversion Group A- 0/11 TAPGroup B 6/10 DC cardioversionP=0.02 N/AP=0.31 NSR in TAP vs. DC cardioversionNSVT p= 0.02 Group A vs. BTAP is safe and effective and was well tolerated and is as efficacious as DC cardioversionEllenbogen KA1995 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFy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ADDIN EN.CITE.DATA (188)7801862To demonstrate the efficacy of various doses of IV diltiazem for heart rate controlOpen label, dose titration study. 84 pts w/ AF, atrial flutter, or bothBolus dose of diltiazem followed by continuous infusion w/ monitoring of heart rate and BPN/A84 consecutive pts w/ AF or flutter, or both, received an IV bolus dose of diltiazem followed by a continuous infusion of diltiazem at 5, 10, and 15 mg/h.>18 y, women of child-bearing age, SSS, 3rd degree AV block, WPW, hypotensive SBP <90 mm Hg, allergic to diltiazem. 94% of pts (79 of 84) responded to the bolus dose w/ a >20% reduction in HR from baseline, a conversion to sinus rhythm, or a heart rate <100 bpm. 78 pts received the continuous infusion. After 10 h of infusion, 47% of pts had maintained response w/ the 5 mg/h infusion, 68% maintained response after the infusion was titrated to 10 mg/h, and 76% after titration from the 5 and 10 mg/h infusion to the 15 mg/h dose. For the 3 diltiazem infusions studied, mean (±SD) heart rate was reduced from a baseline value of 144±14 bpm to 98±19, 107±25, 107±22, 101±22, 91±17, and 88±18 bpm at infusion times 0, 1, 2, 4, 8, and 10 h, respectively. By the end of the infusion, 18% of pts (14 of 78) had conversion to sinus rhythmStatistically significant change in BP before and after 20 mg bolus during infusion. NS difference in BP, after infustion at h 0, 1, 2, 4, 8, and 10. N/AContinuous infusion 10 h response at 5 mg/h (95% CI for 5 mg/h: 36-59; 95% CI for 10 mg/hr: 57-79%)IV diltiazem is safe and effective at slowing heart rate in AF or flutter. Treatment related symptomatic hypotension (3.5-13% w/ hypotension) was most common. Hou ZY1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvdTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvdTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (189)7671898Cardioversion w meds: Randomized, open label, digoxin-controlled study to observe efficacy and safety of dosing regimen of amiodarone in recent-onset, persistent AF and atrial flutter w/ ventircular rates >130 BPM.51Randomly assigned to either IV amiodarone (n=26) or digoxin (n=24)Amiodarone infused over 24 h (decreasing doses/h)Digoxin inf/used- 0.013 mg/kg in 3 divided dosesAmiodarone vs. digoxinPotentially useful for a recommendationRecent-onset, persistent, AF and flutter w/ ventricular rates above 130 beats.Heart rate control: Mean HR in amiodarone group decreased from 157 + 20 to 122+ 25 BPM in 1 hr (p<0.05) and further stabilized to 96±25 BPM after 6 h (p<0.05).Fewer HR reductions in digoxin group (p<0.05)amiodarone infusion was prematurely aborted in two pts due to severe bradycardia and death after conversion in one pt and aggravation of HF in the otherN/AAmiodarone reduced HR significantly more than digoxin at 1 and 6 h (p<0.05 both time frames)Demonstrated HR control w/ amiodarone.Sung RJ1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN1bmc8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN1bmc8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (190)7900626Cardioversion w medsMulticenter, randomized, double-blind, placebo controlled study: Placebo vs. sotalol93Two phased study:Phase 1: randomized placebo infusion vs. 1.0 or 1.5 mg/kg IV sotalol. (30 min observation)Phase 2: if not converted or if HR not fall to <100, 1.5 mg/kg sotalol givenPhase 1 sotalol vs. placeboPhase 2 no comparetorSpontaneous or induced SVT (n=45) or atrial flutter/fibrillation (n=48)N/ASVT phase 1 conversion to NSR 2/14 (14%) w/ placeboSVT phase 1 conversion to NSR 10/15 (67%) sotalol 1.0 mh/kg (p<0.05 vs. placebo)SVT phase 1 conversion to NSR 10/15 (67%) sotalol 1.5 mg/kg (p<0.05 vs. placebo)SVT open label 7/17 (41%) conversion to NSR w/ 1.5 mg/kg sotalolAF phase 1 conversion to NSR 2/14 (14%) w/ placeboAF phase 1- 2/11 (11%) conversion to NSR w/ 1.0 mg/kg sotalol (p=NS vs. placebo)AF phase 1- 2/16 (13%) to NSR 1.5 mg/kg sotalol (p=NS vs. placebo)N/AN/APhase 1 SVT sotalol 1.0 mg/kg and 1.5 mg/kg vs. placebo, sotalol superior (p<0.05 for each dose)Phase 1 sotalol vs. placebo conversion of AF 1.0 mg/kg and 1.5 mg kg not different (p=NS for both doses)Sotalol was effective at terminating SVT but not AFDoni F1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbmk8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbmk8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNO
dW0+MjE2PC9SZWNOdW0+PElEVGV4dD5UeXBlIElJIGF0cmlhbCBmbHV0dGVyIGludGVycnVwdGlv
biB3aXRoIHRyYW5zZXNvcGhhZ2VhbCBwYWNpbmc6IHVzZSBvZiBwcm9wYWZlbm9uZSBhbmQgcG9z
c2libGUgY2hhbmdlIG9mIHRoZSBzdWJzdHJhdGU8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3Vy
bmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4yMTY8L1JlZl9JRD48VGl0
bGVfUHJpbWFyeT5UeXBlIElJIGF0cmlhbCBmbHV0dGVyIGludGVycnVwdGlvbiB3aXRoIHRyYW5z
ZXNvcGhhZ2VhbCBwYWNpbmc6IHVzZSBvZiBwcm9wYWZlbm9uZSBhbmQgcG9zc2libGUgY2hhbmdl
IG9mIHRoZSBzdWJzdHJhdGU8L1RpdGxlX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Eb25pLEYu
PC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TdGFmZmllcmUsRS48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pk1hbmZyZWRpLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5QaWVtb250aSxDLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+VG9kZCxTLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Umltb25kaW5pLEEu
PC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5GaW9yZW50aW5pLEMuPC9BdXRob3Jz
X1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk2LzExPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPmFk
bWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwvS2V5d29yZHM+PEtleXdvcmRzPkFkbWluaXN0cmF0
aW9uLE9yYWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFn
ZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlhbCBG
bHV0dGVyPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaW92ZW50cmljdWxhciBOb2RlPC9LZXl3b3Jk
cz48S2V5d29yZHM+Q2FyZGlhYyBQYWNpbmcsQXJ0aWZpY2lhbDwvS2V5d29yZHM+PEtleXdvcmRz
PkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5jbGFzc2lmaWNhdGlvbjwvS2V5d29yZHM+
PEtleXdvcmRzPkNvbWJpbmVkIE1vZGFsaXR5IFRoZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5k
cnVnIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5FbGVjdHJpYyBDb3VudGVyc2hvY2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJv
Y2FyZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29yZHM+RXNvcGhhZ3VzPC9LZXl3b3Jkcz48S2V5
d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5d29yZHM+PEtl
eXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkl0YWx5PC9LZXl3b3Jkcz48S2V5d29y
ZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5N
aWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvcGFmZW5vbmU8L0tleXdv
cmRzPjxLZXl3b3Jkcz50aGVyYXBldXRpYyB1c2U8L0tleXdvcmRzPjxLZXl3b3Jkcz50aGVyYXB5
PC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4xOTU4
PC9TdGFydF9QYWdlPjxFbmRfUGFnZT4xOTYxPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5QYWNpbmcg
Q2xpbi5FbGVjdHJvcGh5c2lvbC48L1BlcmlvZGljYWw+PFZvbHVtZT4xOTwvVm9sdW1lPjxJc3N1
ZT4xMSBQdCAyPC9Jc3N1ZT48SVNTTl9JU0JOPjAxNDctODM4OTwvSVNTTl9JU0JOPjxBZGRyZXNz
PkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgUG9saWNsaW5pY28gU2FuIFBpZXRybywgUG9udGUg
U2FuIFBpZXRybywgQmVyZ2FtbywgSXRhbHk8L0FkZHJlc3M+PFdlYl9VUkw+UE06ODk0NTA3Nzwv
V2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5QYWNpbmcgYW5kIGNsaW5p
Y2FsIGVsZWN0cm9waHlzaW9sb2d5IDogUEFDRTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3Vy
bmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+UGFjaW5nIENsaW4uRWxlY3Ryb3BoeXNpb2wu
PC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlE
PjwvTURMPjwvQ2l0ZT48L1JlZm1hbj5=
ADDIN EN.CITE.DATA (191)8945077Pace termination (randomized):Comparison of TAP in Type 2 atrial flutter w/ or w/o propafenone12 pts w/ type 2 atrial flutter12 pts w/ type 2 flutter randomized to 2 groups:Group A- TAP on no medsGroup B- TAP 2 h after propafenone 600 mgMean age = 59 y. Symptomatic atrial flutter, all pts had negative P waves in leads II, III, and aVF. N/ANSR achieved in Group A-0/6 (no meds)Group B- 4/6 on PPFFlutter CL: propafenone slowed flutter cycle: 219±33 vs. 168±8 msec, p<0.05N/ANSR in Group A vs. Group B (P<0.05).Flutter cycle legth propafenone vs. no meds, p<0.05Propafenone facilitated pace termination in those pts in whom a slowing of flutter CL occurred but not in those w/ unchanged atrial flutter CLEllenbogen KA1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVsbGVuYm9nZW48L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFy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ADDIN EN.CITE.DATA (192)8752805Cardioversion w meds: Randomized to single IV dose Efficacy of IV ibutilide vs. placebo for AF or flutter –dose response study. 200 pts AF or atrial flutter 3H-90 dPts randomized to single IV dose vs. placebo159 randomized to ibutilde:41 at 0.005 mg/kg40 at 0.10 mg/kg38 at 0.015 mg/kg40 at 0.025 mg/kg41 randomized to placeboAF or A flutter 3 h- 90 dChildbearing age, MI <3 m, class I and III antiarrhythmics discontinued for 5 half lives, AF >3 d, anticoags >2 wk before ibutilideConversion to NSR during or w/in 60 min of infusion:24% conversion to NSR in drug treated group vs. 3% in placebo. Conversion rates at successive doses: 12%, 33%, 45%, 46%. Polymorphic VT occurred in 3.6%N/APlacebo and 0.005 mg/kg ibutilide vs. all other groups lower success (p<0.05).No other statisticIbutilide can rapidly terminate AF and flutterStambler BS1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0YW1ibGVyPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0YW1ibGVyPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48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ADDIN EN.CITE.DATA (193)8840852Multicenter study . Safety and efficacy study Varying doses of ibutilide226133 AF133 atrial flutterRandomized to up to 2 10-min doses Ibutilide separated by 10 min. Ibutilide doses= 1.0 and 0.5 mg or 1.0 and 1.0 mg. This was compared to placebo.AF and atrial flutter.Arrhythmia of 3 h to 45 d durationPt could not be <18 y, weight >300lbs, h/o of torsade, on ibutilide previously, MI, cardiac surgery <30 d, have digoxin toxicity, hyperthyroidism, not on class IConversion rates were:47% w/ ibutilide vs. 2% w/ placebo (p<0.001)Efficacy in flutter >AF: 63% vs. 31%, p<0.001In AF (but not flutter) conversion rates higher in those w/ shorter duration arrhythmiaThe 2 ibutilide dosing regimens did not differ in conversion efficacy (44% vs. 49%).Polymorphic VT in 8.3% (15 pts) (3 required cardioversion, 12 did not)N/AIbutilide vs. placebo (p<0.001)Efficacy in flutter vs. AF: (p<0.001)No difference in conversion at different doses (p=NS)Ibutilide in repeated doses is effective in terminating AF and flutterVolgman AS1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZvbGdtYW48L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZvbGdtYW48L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (194)9581743Cardioversion w meds: Multicenter study- compare efficacy and safety of ibutilide vs. procainamide for conversion of recent onset AF or flutt127Conversion to NSR: randomized to either 2 10 min infusions of 1 mg ibutilide separated by 10 min vs. 3 successive 10 mg- /IV infusions of 400 mg procainamide120 pts eval for efficacy:60 received ibutilide60 received proc(Ibutilide vs. procainamide)2 h to 90 d AF or flutterN/A120 evaluated for efficacy of conversion in 1.5 h:35/60 (58%) ibutilide to NSR11/60 (18.3%) procain converted to NSR (p=0.0001)Flutter- ibutilide significantly more effective than procain (76% 13/17 vs. 4% 3/22; p=0.001.AF- ibutilide significantly more effective than procain (51% 22/43 vs. 21% 8/38; p=0.005.PMVT- 1 pt in ibutilide groupHypotension- 7 pt in procainamide groupN/AIbutilide more successful at conversion n 1.5 h vs. procainamide (p<0.0001)Flutter: ibutlide superior to procain (p=0.001)AF- ibutilide superior to procain (p=0.005Ibutilide was superior to procainamide at converting either AF or flutt. Hypotension was major AE for procainamide. Low incidence of serious proarrhythmia wth ibutilide.Vos MA1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZvczwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZvczwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051
bT4yMzg8L1JlY051bT48SURUZXh0PlN1cGVyaW9yaXR5IG9mIGlidXRpbGlkZSAoYSBuZXcgY2xh
c3MgSUlJIGFnZW50KSBvdmVyIERMLXNvdGFsb2wgaW4gY29udmVydGluZyBhdHJpYWwgZmx1dHRl
ciBhbmQgYXRyaWFsIGZpYnJpbGxhdGlvbi4gVGhlIElidXRpbGlkZS9Tb3RhbG9sIENvbXBhcmF0
b3IgU3R1ZHkgR3JvdXA8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+
Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4yMzg8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5TdXBl
cmlvcml0eSBvZiBpYnV0aWxpZGUgKGEgbmV3IGNsYXNzIElJSSBhZ2VudCkgb3ZlciBETC1zb3Rh
bG9sIGluIGNvbnZlcnRpbmcgYXRyaWFsIGZsdXR0ZXIgYW5kIGF0cmlhbCBmaWJyaWxsYXRpb24u
IFRoZSBJYnV0aWxpZGUvU290YWxvbCBDb21wYXJhdG9yIFN0dWR5IEdyb3VwPC9UaXRsZV9Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+Vm9zLE0uQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PkdvbGl0c3luLFMuUi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN0
YW5nbCxLLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+UnVkYSxNLlkuPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5WYW4gV2lqayxMLlYuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5IYXJyeSxKLkQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5QZXJyeSxLLlQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Ub3Vi
b3VsLFAuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TdGVpbmJlY2ssRy48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PldlbGxlbnMsSC5KLjwvQXV0aG9yc19Qcmlt
YXJ5PjxEYXRlX1ByaW1hcnk+MTk5OC82PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkdWx0PC9L
ZXl3b3Jkcz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQsODAgYW5kIG92
ZXI8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbmFseXNpcyBvZiBWYXJpYW5jZTwvS2V5d29yZHM+PEtl
eXdvcmRzPkFudGktQXJyaHl0aG1pYSBBZ2VudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BcnJoeXRo
bWlhcyxDYXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwvS2V5
d29yZHM+PEtleXdvcmRzPkF0cmlhbCBGbHV0dGVyPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlv
bG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkRpc2Vhc2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5Eb3Vi
bGUtQmxpbmQgTWV0aG9kPC9LZXl3b3Jkcz48S2V5d29yZHM+RHJ1ZyBBZG1pbmlzdHJhdGlvbiBT
Y2hlZHVsZTwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhlcmFweTwvS2V5d29yZHM+PEtleXdv
cmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48S2V5d29yZHM+
SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SHlwb3RlbnNpb248L0tleXdvcmRzPjxLZXl3b3Jk
cz5JbmZ1c2lvbnMsSW50cmF2ZW5vdXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jk
cz48S2V5d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5
d29yZHM+PEtleXdvcmRzPlByb3NwZWN0aXZlIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5S
ZXNlYXJjaDwvS2V5d29yZHM+PEtleXdvcmRzPlNhZmV0eTwvS2V5d29yZHM+PEtleXdvcmRzPlNv
dGFsb2w8L0tleXdvcmRzPjxLZXl3b3Jkcz5TdWxmb25hbWlkZXM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29y
ZHM+PEtleXdvcmRzPlRpbWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdv
cmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjU2ODwvU3RhcnRf
UGFnZT48RW5kX1BhZ2U+NTc1PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5IZWFydDwvUGVyaW9kaWNh
bD48Vm9sdW1lPjc5PC9Wb2x1bWU+PElzc3VlPjY8L0lzc3VlPjxVc2VyX0RlZl81PlBNQzE3Mjg3
MjU8L1VzZXJfRGVmXzU+PElTU05fSVNCTj4xMzU1LTYwMzc8L0lTU05fSVNCTj48QWRkcmVzcz5E
ZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgTWFhc3RyaWNodCwg
TmV0aGVybGFuZHM8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTAwNzgwODM8L1dlYl9VUkw+PFpaX0pv
dXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+SGVhcnQgKEJyaXRpc2ggQ2FyZGlhYyBTb2NpZXR5
KTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3Rl
bSI+SGVhcnQ8L2Y+PC9aWl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dv
cmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (195)10078083Cardioversion w meds: Randomized to receive one of 2 doses of ibutilde or DL sotalol. To compare safety and efficacy308 pts: 251 AF, 57 atrial flutter. Three treatment groups:99 received 1 mg ibutilide106 received 2 mg ibutilide103 received 1.5 mg/kg DL-SotalolN/AAF or flutter: Duration 3 h - 45 dHyperthyroidism, UA, bronchospasm, MI or cardiac surgery <30 ds, 2 and 3rd degree AV block, BBB, WPW, torsade de pointesConversion to NSR w/in 1 hr of treatment.Both drugs were more effective w/ atrial flutter than fib. Ibutilide was more effective than DL-sotalol achieving SNR in atrial flutter in: 70% and 56% vs. 19%.High dose ibutilide was more effective than DL-Sot in AF (44% vs. 11%) and than low dose ibutilide (44% vs. 20%, p<0.01)Bradycardia (6.5%) and hypotension (3.7%) were more common side effects w/ DL-sotalol. Of 211 pts given ibutilide, two (0.9%) who received the higher dose developed polymorphic VT, one of whom required direct current cardioversionN/AHigh dose I more effective than. DL Sotalol and than low dose I in AF (p<0.01)Ibutilide was more effective than DL sotalol. Duration of atrial flutter or AF was predictor of success.Benditt DG1999 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlbmRpdHQ8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlbmRpdHQ8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (196)10496434Prospective dose finding studyRandomizedSotalol 80 BID (59) Sotalol 120 BID (63) Sotalol 160 BID (62) Placebo (69) N/A50 pts - outpatient134 pts - inpatientSHD 57%H/o torsade de pointes, CHF, QI >450 msec, hypokalemia, hypomagenesemia, bradycardia. Time to first recurrent symptomatic AF and/or atrial flutter after reaching drug steady state (p=0.004, significant longer time to recurreance for sotalol 120 mg BID vs. placebo)No cases of VT/VF/torsadeQT>520 ms in 7 pts (4 in 120 mg BID and 3 in 160 mg BID)Premature discontinuation due to AEs 25% inpatients, but 6% of outpatients (bradycardia predominantly)N/AN/AIt is unrealistic to define efficacy in tx of AF and atrial flutter.HF pts for AF and atrial flutter not evaluated.Doni F2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbmk8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbmk8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (197)170334595Pace termination of atrial flutter via trans esophageal pacing.Randomized to 4 groups ?80Randomized to 4 groups:A) Short bursts (5 sec) atrial pacing w/o drugB) Short bursts (5 sec) atrial pacing after propafenone 600 mgC) Long burst (30 sec) atrial pacing w/o drugD) Long burst (30 sec) atrial pacing after propafenone 600 mgN/AAtrial flutter- new onsetN/ASuccessful flutter pace termination in: 20% 55%50%85% N/AN/A(p<0.05: C vs. A) (p<0.05: D vs. B).(p<0.05: B vs. A and D vs. C)No other stats providedPropafenone + long bursts of atrial pacing was best at terminating atrial flutter?Natale A2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5hdGFsZTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+PFJl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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5hdGFsZTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (198)10841241Multicenter prospective randomized comparison of antiarrhythmic therapy vs. first-line RF ablation in pts w/ atrial flutter.61Group 1: 30 randomized to drug therapy Group 2: 31 randomized to RFAInclusion: At least two symptomatic episodes of atrial flutter in the last four mo. .Exclusion:1) prior evidence of AF (AF); 2) the presence of significant left atrial enlargement (≥4.5 cm); and 3) previous treatment w/ antiarrhythmic medications1) Rehospitalization: medication group- 63% required one or more rehospitalizations, vs. post-RF ablation, 22% of pts were rehospitalized (p<0.01). 2) Post RF ablation, 29% developed AF vs. 53% of pts receiving medications (p<0.05). 3) Sense of well being (pre-RF 2.0±0.3 vs. post-RF 3.8±0.5, p<0.01) and function in daily life (pre-RF 2.3±0.4 vs. post-RF 3.6±0.6, p<0.01) improved after ablation, but did not change significantly in pts treated w/ drugs.N/AN/A1) Rehospitalization more common w/ meds (p<0.01)2) AF more common post RFA than meds (p<0.05)3) Sense on well being improved w/ RFA but not meds (change in scoe p<0.01)RF ablation could be considered a first-line therapy due to the better success rate and impact on QOL, the lower occurrence of AF and the lower need for rehospitalization at f/u.Delacretaz E2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGFjcmV0YXo8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGFjcmV0YXo8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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ADDIN EN.CITE.DATA (199)11345382Ablation: Single center, non-randomized trial comparing ablation of multi IART circuits in adults w/ CHD guided by entrainment mapping w/ and w/o 3D electroananatomic mapping20 pts (47 circuits)To define an approach for mapping and ablation, combining anatomy, activation sequence data and entrainment mapping. a) 7 pts w/ ablation guided by entrainment mapping onlyb)13 pts w/ ablation guided by entrainment and 3D electroanatomic mappingN/ARecurrent IART refractory to meds.Late post repair of CHDOverall 38 (81%) of 47 IARTs successfully ablated. In f/u ranging from 3-46 mo:a)16 (80%) of 20 pts remains free of recurrenceb)Success similar in both groups but fluoroscopy time decreased from 60 +/- 30 to 24 +/- 9 min/procedure w/ addition of 3D electroanatomic mappingN/AN/ANo statistical analysisEntrainment mapping combined w/ 3D electroanatomic mapping allows delineation of complex re-entry circuits and critical isthmuses as targets for RFA as a satisfactory treatment modality for IARTs related to CHD.Delle Karth G2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGxlIEthcnRoPC9BdXRob3I+PFllYXI+MjAwMTwvWWVh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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGxlIEthcnRoPC9BdXRob3I+PFllYXI+MjAwMTwvWWVh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==
ADDIN EN.CITE.DATA (200)11395591To compare the efficacy of IV diltiazem bolus/infusion vs. IV amiodarone bolus vs. IV amiodarone bolus/infusion for immediate (4 h) and 24-h rate control during AF Randomized prospective, controlledIV diltiazem bolus/infusion vs. IV amiodarone bolus vs. IV amiodarone bolus/infusion N/ACritically ill pts w/ recent-onset AF w/ ventricular rate >120 bpm N/ASustained heart rate reduction ≥30% w/in 4 h 70% vs. 55% vs. 75% Bradycardia or hypotension 35% vs. 0% vs. 5% Uncontrolled tachycardia 0% vs. 45% vs. 5% 1° endpoint: NS 2° endpoint p<0.00016 Safety endpoint p=0.01 The study speaks about rate control during recent AF or atrial flutter in really sick pts.DIAMOND2001 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlZGVyc2VuPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlZGVyc2VuPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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ADDIN EN.CITE.DATA (201)11457747 RCT, double-blind To evaluate the efficacy of dofetilide to maintain SR in pt w/ LV dysfunction 506 ptsDofetilide 500 mcg/d (249)Placebo (257)Inclusion: Persistent AF associated w/ either HF or recent acute MI Dose reduction for renal insufficiency BBB), K <3.6 or >5.5, CrCl <20 mL/min Exclusion: HR: <50 bpm, QTc >460 msec (500 msec w/Probability of maintaining SR at 1 y 79% dofetilide 42% w/ placebo (p<0.001) No effect on all-cause mortality Dofetilide associated w/ reduced rate of rehospitalization N/ATorsade de pointes occurred in 4 dofetilide pts (1.6%) Subjects not stratified by rhythm. Differences in population, Lft atrial size, LV diastolic dysfunction, and MR could have influenced results.Gallagher MM2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbGxhZ2hlcjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdhbGxhZ2hlcjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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ADDIN EN.CITE.DATA (202)11691530Cardioversion: design a more efficient protocol for the electrical cardioversion of atrial arrhythmias1838 attempts at cardioversion of AF and 678 attempts at cardioversion of flutterAnalyzed the effects of different energy deliveries at terminating either AF or atrial flutter in pts w/ arrhythmias of varying duration.N/AAF or atrial flutter undergoing DC cardioversionN/AConversion rates were:a) AF of >30 d duration = 5.5% at <200 J; 35% at 200 J and 56% at 360 J. b) atrial flutter= 68% at 100 J c) AF of >30 d duration, shocks of <200 J = 6.1% d) AF >180 d= 2.2% at 200 JN/AN/AFor AF >180 d, initial use of a 360 J shock was associated w/ the eventual use of less electrical energy than w/ an initial shock of ≤100 J (581±316 J vs. 758±433 J, p<0.01, Mann-Whitney U test).An initial energy setting of ≥360 J can achieve cardioversion of AF more efficiently in pts than traditional protocols, particularly w/ AF of longer duration.Wazni O2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhem5pPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhem5pPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (203)14610012Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation vs. pulmonary vein-left atrial junction disconnection alone in pts presenting w/ typical atrial flutter and AF.108Consecutive pts w/ documented symptomatic AF and typical atrial flutter were randomly assigned to have PV-LAJ disconnection combined w/ CTI ablation (group 1, n=49) or PV-LAJ disconnection alone (group 2, n=59).PV-LAJ disconnection combined w/ CTI ablation (group 1, n=49) or PV-LAJ disconnection alonePreablation proof of both atrial flutter and AF on ECG, 1 documented episode of typical atrial flutter while not on antiarrhythmicsN/AW/in the first 8 wk after ablation, 32 of the group 2 pts had typical atrial flutter documented, whereas none was seen in group 1. Twenty of these 32 converted to sinus rhythm after initiating AADs. Twelve were cardioverted, and AADs were started. After 8 wk, all AADs were stopped, and only 3 pts continued to have recurrent sustained typical atrial flutter that was eliminated by CTI ablation. Beyond 8 wk of f/u, 7 pts in group 1 and 6 pts in group 2 (14% and 11%, respectively) continued to have AF. Ten of these 13 pts underwent a repeat PV-LAJ disconnection procedure and were cured. The remaining 3 remained in normal sinus rhythm while taking AADs.N/AN/AN/AIsolating of all 4 pulmonary vs. is challenging. No f/u beyond 1 y. LADIP Trial2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhIENvc3RhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhIENvc3RhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA (204)17030680Randomized study comparing amiodarone and RF ablation after the first episode of symptomatic atrial flutter104 pts w/ atrial flutter:group I= 52 pts treated w/ RFA as 1st lineGroup2 treated w/ cardioversion and amiodarone as 1st line1 episode of symptomatic typical atrial flutterN/ARecurrence of flutter: 3.8% after RFA vs. 29.5% w/ amiodarone and cardioversion; p<0.0001Complications of treatment:Five complications (10%) were noted in group II (SSS in 2, hyperthyroidism in 1, and hypothyroidism in 2) and none in group I (0%) (P=0.03).long-term risk of subsequent AF (AF):25% after RFA vs. 18% after amiodarone and cardioversion (p=NS)RFA reduced recurrences of flutter vs. amiodarone and caridoversion (p<0.0001)RFA not different than amiodarone and cardioversion at occurrence of AF (p=NS). Fewer complications w/ RFA than amiodarone + cardioversion (p=0.03)RFA should be considered first line therapy even after 1 recurrence of atrial flutterKuniss M2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1bmlzczwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1bmlzczwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE.DATA (205) 19959115Prospective randomized comparison of durability ofbidirectional conduction block in the cavotricuspid isthmus inpts after ablation of common atrial flutter usingcryothermy and RF energy: The CRYOTIP study191Cryoablation Do people use this for atrial flutter ablation?Vs. standard RFAInclusion: 1. One episode of ECG-documented typical atrial flutter symptomatic w/ eligibility for ablation treatment2. Age between 18 and 80 y3. Written informed consent for the ablation procedure andthe invasive f/u procedure after 3 mo.Exclusion: atypical flutterAcute success rates: 91% (83/91) in the RF group vs. 89% (80/90) in the cryoablation group (P=NS). Invasive2) f/u 3 mo EP study available for 60 pts in the RF group and 64 pts in cryoablation group. 3) Persistent BCB confirmed in 85% of the RF group vs. 65.6% of the cryoablation group. 4)The primary end-point= nonpersistence of BCB block was seen in 15% of the RF group vs. 34.4% of the cryoablation group (P<0.014). N/ASecondary end-point-pain perception during ablation was significant lower in the cryoablation group (P<0.001)Acute success RFA vs. cryoablation (p=NS)Pesristent BCB- cryoablation inferior to RFA (p<0.014)Persistence of BCB in pts treated w/ cryoablationreinvestigated after 3 mo is inferior to that ptstreated w/ RF ablation, as evidenced by the higher recurrencerate of common atrial flutter seen in this study.Steinwender C2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZWlud2VuZGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZWlud2VuZGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN EN.CITE.DATA (206)19136164Randomized placebo controlled Trial: Assess pretreatment w/ magnesium for conversion w/ Ibutilide: Randomized 117 pts (58 w/ and 59 w/o pre-injection of magnesium; 65 w/ typical atrial flutter and 52 w/ atrypical atrial flutter. 117- 65 typical flutter; 52 atypical flutter2 randomized groups:Group 1) 4 g of IV magnesiumsulfate Vs. Group 2) placebo immediately before administration of a maximum dose of 2 mg of ibutilide fumarateTypical and atypical atrial flutterN/A1) TAF: pre-injection IV magnesium improved efficacy of ibutilide for conversion (85% w/ magnesium vs. 59% w/ placebo, p=0.017).Atypical atrial flutter: no significant difference in conversion rates between pts receiving magnesium vs. placebo (48% vs. 56%,p=0.189)No effect of magnesium on QTc interval.QTc intervals at 30 min after ibutilitde did not differ between patients w/ and w/o ventricular ectopyN/APreinjcention w/ Mg superior for conversion w/ ibutilide in trypical atrial flutter (p=0.017)Preinjection w/ Mg for conversion w/ ibutilide no different (p=NS)Preinjection wih Mg did not affect QT (no statistic offered)Pre-injection of magnesium significantly enhances the efficacy of ibutilide for the conversion of typical atrial flutter but not of atypical atrial flutter.Bastani H2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhc3Rhbmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhc3Rhbmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (207)22927662 Randomized comparison in pts w/ typical atrial flutter. RFA- 3.5 mm open-irrigated-tip catheter and Cryoablation a 9 F, 8 mm tip catheter. Ablation endpoint was bidirectionalCTI block.153Ablation RFA- 3.5 mm open-irrigated-tip catheter (N= 75)Cryoablation a 9 F, 8 mm tip catheter (N=78)Inclusion: Pts w/ a h/o AF included if they had predominant atrial flutter under chronic treatment w/ class I or III antiarrhythmic agents.Exculsion: (i) prior ablation for atrial flutter; (ii) atrial flutter related to recently undergone surgery, hyperthyroidism or other severe disease; (iii) inability to adhere w/ the study protocol; (iv) pregnancy; (v) predominant AF; and (vi) contraindication to warfarin.Primary endpoint: demonstration of long-term efficacydefined as no symptomatic recurrence of atrial flutter at the 6-mo f/u.Success rate at 6-mo f/u was 93% (73 of 78) for Cryoablation vs. 97% (73 of 75) for RF (p= 0.86).safety assessed by the rate of periprocedural complications, procedure and fluoroscopy times, and the level of pain experienced by the pt during the ablation procedureProcedural time was longer in the cryoablation group (152±54 min) than the RF group (116±41 min) (P<0.001). Cryoablation was less painful compared w/ RF (mean VAS-Cryoablation 0.7±1.2 vs. VAS-RF 4.6±2.0; P<0.001). Secondary end-points: acute ablation success defined as bidirectional CTI-block;Acute success rate 92% for cryoablation vs. 95% for RF (p=0.58).1) Acute success rate for Cryoablation vs. RF (p=0.58).2) Procedural time was longer in the Cryoablation group vs. RF group (p<0.001). 3) Cryoablation was less painful compared vs. RF (p<0.001). 4) Success rate at 6-mo f/u was no different for Cryoablation vs. RF (P= 0.86). No major adverse events occurred in any group.Cryoablation is not inferior to RFA for typical flutterMohanty s2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1vaGFudHk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1vaGFudHk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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 EN.CITE.DATA (208) 23572499Single-blind, randomized study- Examined the impact of different ablation strategies on AF recurrence and QOL in coexistent AF and atrial flutter.360 pts w/ documented AF and atrial flutterBlinded and randomized to group 1, AF±atrial flutter ablation (n=182), or group 2, atrial flutter ablation only (n=178). AF recurrence was evaluated w/ event recording and 7-d Holter at 3, 6, 9, and 12-mo f/us. QOL was assessed at baseline and at the 12-mo f/u w/ 4 questionnaires.AF ± atrial flutter ablation vs. atrial flutter ablation only1 antiarrhythmic and preablation evidence of typical atrial flutter by 12-lead surface ECG.<18 or >85 y old, previous ablation, left atrium size ≥5 cm, or contraindication to oral anticoagulationAt 21±9 mo of f/u, 117 in group 1 (64%) and 34 in group 2 (19%) were arrhythmia free (P<0.001). In group 1, scores on most quality-of-life subscales showed significant improvement at f/u, whereas group 2 pts derived relatively minor benefit.N/AN/AGroup 1 vs. Group 2 p<0.001Questionnaires didn’t address comorbidities, smaller sample sizeAAD, antiarrhythmic drug; AE, adverse events; AF, atrial fibrillation; AMI, acute myocardial infarction; AV, atrioventricular; BBB, bundle branch block; BCB, bidirectional conduction block; bid, two times per day; BP, blood pressure; bpm, beats per min; CHD, congenital heart disease; CHF, congestive heart failure; CI, confidence interval; CL, cycle length; CrCl, creatinine clearance; CTI, cavotricuspid isthmus; DC, direct current; ECG, electrocardiogram; EP, electrophysiological; f/u, follow up; HF, heart failure; h/o, history of; HR, heart rate; IART, intraatrial reentrant tachycardia; IV, intravenous; LBBB, left bundle branch block; LV, left ventricular; MI, myocardial infarction; MR, mitral regurgitation; N/A, not applicable; NS, non-significant; NSR, normal sinus rhythm; NSVT, non-sustatined supraventricular tachycardia; NYHA, New York Heart Association; pt, patient; PV-LAJ, pulmonary vein-left atrial junction; QTc, corrected QT interval; RCT, randomized controlled trial; RF, radiofrequency; RFA, radiofrequency ablation; SBP, systolic blood pressure; SD, standard deviation; SHD, structural heart disease; SR, sinus rhythm; SSS, sick sinus syndrome; SVT, supraventricular tachycardia; TAP, transesophageal atrial pacing; tx, transplant; VAS, visual analog scale; VF, ventricular fibrillation; VT, ventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 17. Nonrandomized Trials, Observational Studies, and/or Registries of Atrial Flutter – Section 7StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsVan Gelder IC1989PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBHZWxkZXI8L0F1dGhvcj48WWVhcj4xOTg5PC9ZZWFy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ADDIN EN.CITE.DATA (181)2511744 Persistent AF and atrial flutter after cardioversion randomized to flecainide or no therapy to reduce recurrence81 pts (16 pts with atrial flutter – 6 in flecainide group and 10 in control group)Inclusion: Persistent AF and atrial flutter referred for cardioversion. All pts w/ atrial flutter received verapamil 240 mg daily to reduce 1:1 AV conduction.Exclusion: <16 y or >80 y, CHF, angina, MI <2 y before, bifascicular block or bundle branch block, sick sinus syndrome without pacemaker, severe systemic diseaseArrhythmia-free survival after cardioversionNo significant difference in arrhythmia free survival. However, it postponed time to arrhythmia recurrence.Adverse effects: 9% flecainide group experience side effects. 3 pts in flecainide group required pacemaker (2 w/ symptomatic sinus arrest and 1 with AV block). 1 pt had increase ventricular ectopy burden requiring discontinuation.No significant difference in arrhythmia free survival in pts w/ persistent AF or atrial flutter. However, it postponed time to arrhythmia recurrence after cardioversion.Pietersen 1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Pietersen</Author><Year>1991</Year><RecNum>633</RecNum><IDText>Usefulness of flecainide for prevention of paroxysmal atrial fibrillation and flutter. Danish-Norwegian Flecainide Multicenter Study Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>633</Ref_ID><Title_Primary>Usefulness of flecainide for prevention of paroxysmal atrial fibrillation and flutter. Danish-Norwegian Flecainide Multicenter Study Group</Title_Primary><Authors_Primary>Pietersen,A.H.</Authors_Primary><Authors_Primary>Hellemann,H.</Authors_Primary><Date_Primary>1991/4/1</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Denmark</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>prevention & control</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>713</Start_Page><End_Page>717</End_Page><Periodical>Am J Cardiol</Periodical><Volume>67</Volume><Issue>8</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Medical Department B, Rigshospitalet, Copenhagen University, Denmark</Address><Web_URL>PM:1900978</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(209)1900978Randomized, placebo controlled cross over design trial flecainide 150 mg bid vs. placebo. Pts received 3 mo of therapy w/ another 3 mo of crossover therapy.43 ptsInclusion: Paroxysmal AF or atrial flutter >3 episodes <3 mo prior to enrollmentExclusion: CHF, reduced LV fractional shortening, WPW, syncope, thyroid disease, sinus node dysfunction w/o pacer, more than isolated PVC’sNumber of symptomatic recurrencesOutcome: Significant reduction in number of episodes with flecainide treatment (p<0.002).Adverse events: 1 pt developed 1:1 conduction of atrial flutter. 1 sudden death in flecainide group (bathing in the cold Norway sea after drinking alcohol). Other minor adverse events occurred in 74% (mostly visual changes, dizziness, and GI side effects) resulting in 2 withdrawals.Flecainide significantly redcuced the number of recurrent episodes of AF or flutter. Aliot E1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsaW90PC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFsaW90PC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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 EN.CITE.DATA (210)8607394 Randomized, open-label, long-term, parallel, comparative multicenter study comparing propafenone to flecainide97 pts (5 with atrial flutter)Inclusion: adults with paroxysmal AF or atrial flutter on ECG or HolterExclusion: MI, recent heart surgery, VT, CHF, PR >280 ms, QRS >150 ms, sinus node dysfunction or heart block in absence of pacemakerProportion of pts remaining on therapy at 1 y0.619 remained on flecainide 1 y0.469 propafenone Adverse events: 1 death in propafenone group. 8.5% flecainide experienced neurological side effects, 16% propafenone group GI side effectsIn paroxysmal AF and paroxysmal atrial flutter, flecainide and propafenone not significantly different. Too few pts with atrial flutter to draw conclusions. Rate of side effects was greater with propafenone.Baker1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJha2VyPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJha2VyPC9BdXRob3I+PFllYXI+MTk5NjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (211)8800118Single center trial evaluating efficacy of anatomically based RFA ablation for the treatment of IART in pts w/ previous atrial surgery14 ptsH/o atrial surgery and clinical intraatrial reentrant tachycardiaFreedom from recurrence of IARTSuccessfully terminated in 13 pts (93%). Six pts required repeat ablation for recurrence. Twelve (86%) remained free of IART at 7.5 mo.RFA is effective technique for IART in pts w/ previous atrial surgeryKalman JM1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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 EN.CITE.DATA (212)8565168Single center observation cohort study to evaluate the success of RFA for IART in CHD using targeted ablation of critical isthmus18 ptsIART and repaired CHDAcute successSuccessful termination in 15 pts (21 arrhythmias). During f/u (mean 17 mo), 11 pts (61%) remained free of recurrence (2 remained on antiarrhythmic drug)Describes early experience w/ targeted RF to critical isthmus in pts w/ repaired CHD. Successful ablation IART can be achieved w/ ablation to critical isthmus of conduction.Triedman1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRyaWVkbWFuPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRyaWVkbWFuPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48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ADDIN EN.CITE.DATA (213)9316535Single center retrospective trial evaluating the short and mid term efficacy of RFA for IART in CHD45 ptsPts w/ CHD w/ IART undergoing RFANon-isthmus dependent flutter instead of IARTFreedom from recurrence of IART73% acutely successful. Recurrence 53% during mean f/u of 17.4 mo. Seven underwent repeat ablation.Early experience w/ RFA for IART in CHD reduced events in population of pts. However, recurrence was frequent often w/ new IART circuits.Huang DT1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1YW5nPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1YW5nPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (214)9607453Single center trial assessing efficacy of combining pharmacologic and simple ablative therapies in treating AF in small targeted subset of pts13 pts w/ AF who converted to electrocardiographic atrial flutter during anti-arrhythmic treatment“Typical” atrial flutter in 11 pts and “atypical” atrial flutter in 2 suggested by surface ECG.Intracardiac mapping and entrainment studies found 9 pts w/ CCW isthmus dependent atrial flutter and remaining 4 had complex activation patterns.Successful ablation w/o recurrence at mean f/u 14.3±6.9 moAll 9 pts w/ typical atrial flutter had successful ablation and 88.9% maintained sinus rhythm in f/u period (while continued on antiarrhythmic drugs)None of 4 pts w/ complex activation patterns had successful ablationIn pts who experience conversion of AF to typical isthmus dependent flutter during anti-arrhythmic drug therapy, ablation and continuation of pharmacologic therapy is effective in maintaining sinus rhythm.Chan DP2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Chan</Author><Year>2000</Year><RecNum>243</RecNum><IDText>Importance of atrial flutter isthmus in postoperative intra-atrial reentrant tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>243</Ref_ID><Title_Primary>Importance of atrial flutter isthmus in postoperative intra-atrial reentrant tachycardia</Title_Primary><Authors_Primary>Chan,D.P.</Authors_Primary><Authors_Primary>Van Hare,G.F.</Authors_Primary><Authors_Primary>Mackall,J.A.</Authors_Primary><Authors_Primary>Carlson,M.D.</Authors_Primary><Authors_Primary>Waldo,A.L.</Authors_Primary><Date_Primary>2000/9/12</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child,Preschool</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>Electrophysiology</Keywords><Keywords>etiology</Keywords><Keywords>Heart</Keywords><Keywords>Heart Diseases</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Reprint>Not in File</Reprint><Start_Page>1283</Start_Page><End_Page>1289</End_Page><Periodical>Circulation</Periodical><Volume>102</Volume><Issue>11</Issue><ISSN_ISBN>1524-4539</ISSN_ISBN><Address>Division of Pediatric Cardiology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA</Address><Web_URL>PM:10982544</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(215)10982544Single center study assessing the importance of atrial flutter isthmus in post-operative IART19 postoperative CHD pts w/ IARTAll study pts underwent EP study w/ entrainment mapping of atrial flutter isthmuses to determine PPIs. RFA performed at identified isthmus to create line of block.Successful ablation 21 IARTS identified in 19 ptsAtrial flutter isthmus part of circuit in 15 of 21 (71.4%)Sites near atrial incisions or suture lines in remaining 6 of 21 Ablation successful in 19 of 21 (90.4%) of IARTs and in 14 of 15 cases of at the atrial flutter isthmus (93.3%)When IART occurs late after repair of CHD, atrial flutter isthmus may be part of reentrant circuit and should be evaluated as a target for ablation. Jais2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Jais</Author><Year>2000</Year><RecNum>247</RecNum><IDText>Mapping and ablation of left atrial flutters</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>247</Ref_ID><Title_Primary>Mapping and ablation of left atrial flutters</Title_Primary><Authors_Primary>Jais,P.</Authors_Primary><Authors_Primary>Shah,D.C.</Authors_Primary><Authors_Primary>Haissaguerre,M.</Authors_Primary><Authors_Primary>Hocini,M.</Authors_Primary><Authors_Primary>Peng,J.T.</Authors_Primary><Authors_Primary>Takahashi,A.</Authors_Primary><Authors_Primary>Garrigue,S.</Authors_Primary><Authors_Primary>Le,Metayer P.</Authors_Primary><Authors_Primary>Clementy,J.</Authors_Primary><Date_Primary>2000/6/27</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Atrial Function,Left</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>France</Keywords><Keywords>Heart Block</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Neural Conduction</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Pulmonary Veins</Keywords><Keywords>Radiosurgery</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>2928</Start_Page><End_Page>2934</End_Page><Periodical>Circulation</Periodical><Volume>101</Volume><Issue>25</Issue><ISSN_ISBN>1524-4539</ISSN_ISBN><Address>Hopital Cardiologique du Haut-Leveque, Bordeaux-Pessac, France</Address><Web_URL>PM:10869265</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(216)10869265Single center retrospective observational trial to assess efficacy of mapping guided RFA22 ptsPts w/ persistent left atrial flutter predominantly in pts w/ SHD. 18 (81%) failed amiodarone.Acute success and mid-term f/uComplete activation map achieved in 17/22 pts. 20 pts (90%) in sinus rhythm at the end of procedure.7 pts required 2 procedures and 1 pt required 3 procedures. During mean 15 mo f/u, 16 pts (73%) remained free of recurrence (2 remained on antiarrhythmic).Describes various left atrial reentrant circuits and demonstrated feasibility of mapping guided RFAReithmann C2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Reithmann</Author><Year>2000</Year><RecNum>250</RecNum><IDText>Catheter ablation of atrial flutter due to amiodarone therapy for paroxysmal atrial fibrillation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>250</Ref_ID><Title_Primary>Catheter ablation of atrial flutter due to amiodarone therapy for paroxysmal atrial fibrillation</Title_Primary><Authors_Primary>Reithmann,C.</Authors_Primary><Authors_Primary>Hoffmann,E.</Authors_Primary><Authors_Primary>Spitzlberger,G.</Authors_Primary><Authors_Primary>Dorwarth,U.</Authors_Primary><Authors_Primary>Gerth,A.</Authors_Primary><Authors_Primary>Remp,T.</Authors_Primary><Authors_Primary>Steinbeck,G.</Authors_Primary><Date_Primary>2000/4</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Amiodarone</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>chemically induced</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Germany</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>565</Start_Page><End_Page>572</End_Page><Periodical>Eur Heart J</Periodical><Volume>21</Volume><Issue>7</Issue><ISSN_ISBN>0195-668X</ISSN_ISBN><Misc_3>S0195668X99918651</Misc_3><Address>Medizinische Klinik I, Klinikum Grosshadern, Universitat Munchen, Germany</Address><Web_URL>PM:10775011</Web_URL><ZZ_JournalFull><f name="System">European heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(217)10775011Single center trial assessing catheter ablation of CTI on amiodarone-induced atrial flutter and subsequent incidence of AF in comparison to CTI ablation of regular typical atrial flutter92 consecutive pts w/ typical atrial flutter who underwent CTI ablation3 groups28 pts w/o h/o AF10 pts w/ atrial flutter following amiodarone treatment for PAF54 pt w/ AF and atrial flutterSuccessful CTI ablation w/ bidirectional block eliminating atrial flutter and recurrence of AF during mean f/u 8±3 moSuccessful ablation achieved in 90% of amiodarone-treated pt’s and 93% of pts w/o amiodarone therapyRecurrence of AF occurred in 20% amiodarone treated pts which was similar to pts w/o preexisting AF (25%) and markedly lower than pts w/ atrial flutter plus preexisting PAF (76%)CTI ablation w/ bidirectional block and continuation of amiodarone therapy is effective for treatment of atrial flutter due to amiodarone therapy for PAF.Hybrid therapy belongs in this guideline? Yes. Merit a rec? Yes. Akar JG2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFrYXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxSZWNO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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFrYXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (218)11499727Single center study assessing the coexistence of IART and IDAF in pts w/ SVTs after surgical correction of CHD16 consecutive pts diagnosed w/ both IART and IDAF IART and IDAF diagnosed by standard criteria and entrainment mapping. 7 pts had classic atrial flutter morphology on surface ECG, whereas 9 had atypical morphologySuccessful ablation w/o procedural complication or recurrence at mean f/u of 24 moSuccessful ablation performed in 13 of 14 (93%) IART and 9 of 10 (90%) IDAF circuits.1 IART recurrence otherwise none reported at 24 moSlow conduction zone involved region of right atriotomy scar in 12 of 14 (86%) IART circuitsNo procedural complicationsIDAF and IART are the most common and commonly coexistant mechanisms of atrial re-entrant tachyarrhythmias in pts w/ surgically corrected CHD. Majority of IART circuits involve lateral RA and may be successfully ablated by lesion extending to IVC.Nakagawa2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5ha2FnYXdhPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk5ha2FnYXdhPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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ADDIN EN.CITE.DATA (219)11156882Characterize the circuit of IART in pts w/ repaired CHD and evaluate success of RFA of w/in channels defined by electroanatomic mapping13 pts w/ 15 IARTsPts w/ repaired CHD and IARTAcute and medium term successAblation acutely eliminated inducibility of all 15 IARTs. During f/u of median 13.5 mo, 13 pts (81%) remained free of recurrence. Large area of low voltage scar identified in all pts w/ macroreentrant tachycardias.RFA of IART in pts w/ repaired CHD using electroanatomic mapping and targeting channels has a reasonable success rate. Deal BJ2002PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE.DATA (220)12147539Retrospective non-randomized comparison of cryoablation of inferomedial RA vs. extensive modified RA maze in pts undergoing Fontan revision w/ AT23 ptsPts undergoing Fontan revision w/ ATMaybe shouldn’t be in here since surgical; may be more recent papers breaking down the differences by types of CHDInducibility at f/u EP and long-term freedom from recurrence of ATInducibility of AT: 62% inferomedial RA ablation7% modified RA MAZEP<0.02Freedom from AT (mean 43 mo f/u):62% inferomedial RA ablation0% modified RA MAZEP<0.001Modified RA maze procedure is superior to anatomic isthmus block in treating reentrant AT in postoperative Fontan ptsSpector P2010 ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)19699343Meta-analysis of ablation of atrial flutter and SVT.A meta-analysis of 21 studies RFA in atrial flutter:18 primary studies w/ 22 treatment arms and 1,323 pts)N/AEvaluate the safety and efficacy of RFA of typical atrial flutter and AV node-dependent SVT in adult ptsSingle-procedure success for atrial flutter was 91.7% (95% CI: 88.4%-94.9%). Multiple-procedure success was 97.0% (95% CI: 94.7%-99.4%). Postablation arrhythmia was noted in 13.2% of pts (95% CI: 7.5%-18.9%), while repeat ablation was reported in 8% (95% CI: 4.5%-11.4%).RFA for the treatment of pts w/ atrial flutter and SVT report high efficacy rates and low rates of complications.70% of pts who got ablation didn’t need it; interrelationship for AF and atrial flutter. When to ablate? discussion. AF ablation covered in consensus document. Drive by protein disulfide isomerase vs. drive by flutter ablation. Both ways. Coffey JO2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvZmZleTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvZmZleTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA (221)23385050Retrospective multicenter cohort study to assess the efficacy of RFA on atypical atrial flutter/AT91 pts w/ 171 ATs (1.9 / pt)Pts w/ atypical atrial flutter/AT in pts w/ prior catheter ablation for AF, MAZE or other cardiac surgery, or idiopathic scar. Pts w/ on CTI-dependent flutter were excluded.Acute and long-term successAcute success was 97% for non-septal AT and 77% for septal AT. Long-term success rates 82% in pts w/ no septal AT and 67% in pts w/ 1 or more septal AT. Long-term success rates were 75%, 88%, and 57% for pts w/ ATs associated w/ prior catheter ablation, cardiac sugery/MAZE or idiopathic scar, respectively.High-density activation mapping combined w/ selective entrainment mapping allows for reasonable successful RFA of non-CTI dependent ATs occurring after AF ablation, cardiac surgery, or in the setting of idiopathic scar.Ghali WA2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Ghali</Author><Year>2005</Year><RecNum>657</RecNum><IDText>Atrial flutter and the risk of thromboembolism: a systematic review and meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>657</Ref_ID><Title_Primary>Atrial flutter and the risk of thromboembolism: a systematic review and meta-analysis</Title_Primary><Authors_Primary>Ghali,W.A.</Authors_Primary><Authors_Primary>Wasil,B.I.</Authors_Primary><Authors_Primary>Brant,R.</Authors_Primary><Authors_Primary>Exner,D.V.</Authors_Primary><Authors_Primary>Cornuz,J.</Authors_Primary><Date_Primary>2005/2</Date_Primary><Keywords>analysis</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Canada</Keywords><Keywords>complications</Keywords><Keywords>Echocardiography</Keywords><Keywords>Electric Countershock</Keywords><Keywords>etiology</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Prognosis</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Thromboembolism</Keywords><Reprint>Not in File</Reprint><Start_Page>101</Start_Page><End_Page>107</End_Page><Periodical>Am J Med</Periodical><Volume>118</Volume><Issue>2</Issue><ISSN_ISBN>0002-9343</ISSN_ISBN><Misc_3>S0002-9343(04)00687-4;10.1016/j.amjmed.2004.06.048</Misc_3><Address>Department of Medicine, University of Calgary, Alberta, Canada. wghali@ucalgary.ca</Address><Web_URL>PM:15694889</Web_URL><ZZ_JournalFull><f name="System">The American journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(222)Systematic review and meta-analysis of observational studies that investigated risk of thromboembolism associated with atrial flutter.The meta analysis included 13 studies on embolic risk around time of cardioversion that included 1546 patients. For chronic risk, there were 14 studies involving 17,691 patients.MEDLINE, EMBASE, bibliographies, and consultation with clinical experts were used to identify studies that report the risk of thromboembolism associated with attempted cardioversion and longer-term risk in patients with atrial flutter.Risk of thromboembolism associated with atrial flutter around time of cardioversion or over the long term in chronic atrial flutter.Around the time of cardioversion, the risk of thromboembolic events ranged from 0% to 7.3% depending of clinical factors.Lower event rates were observed in patients taking anticoagulants.The long term risk rate of thromboembolism was approximately 3% with sustained atrial flutter.The findings of this systematic review strongly suggest that atrial flutter does indeed impart a risk of thromboembolism. AF indicates atrial fibrillation; AT, atrial tachycardia; AV, atrioventricular; bid, two times per day; CCW, counter-clockwise; CHD, congenital heart disease; CHF, congestive heart failure; CI, confidence interval; CTI, cavotricuspid isthmus; ECG, electrocardiogram; EP, electrophysiological; f/u, follow up; GI, gastrointestinal; h/o, history of; IART, intraatrial reentrant tachycardia; IDAF, isthmus-dependent atrial flutter; IVC, inferior vena cava; LV, left ventricular; MI, myocardial infarction; N/A, not applicable; PAF, paroxysmal atrial fibrillation; PPI, postpacing interval; pt, patient; PVC, premature ventricular contraction; RA, right atrial; RF, radiofrequency; RFA, radiofrequency ablation; SHD, structural heart disease; SVT, supraventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 18. Randomized Trials for Junctional Tachycardia – Section 8Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Study Limitations & Adverse EventsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsMamchur SE2012 ADDIN REFMGR.CITE <Refman><Cite><Author>Mamchur</Author><Year>2012</Year><RecNum>94</RecNum><IDText>High-amplitude pace mapping increases safety of radiofrequency catheter ablation of parahisian ectopic foci</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>94</Ref_ID><Title_Primary>High-amplitude pace mapping increases safety of radiofrequency catheter ablation of parahisian ectopic foci</Title_Primary><Authors_Primary>Mamchur,S.E.</Authors_Primary><Authors_Primary>Kurilin,M.Y.</Authors_Primary><Date_Primary>2012/12</Date_Primary><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrioventricular Block</Keywords><Keywords>Bundle of His</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Chi-Square Distribution</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Patient Safety</Keywords><Keywords>physiopathology</Keywords><Keywords>prevention & control</Keywords><Keywords>Recurrence</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Reprint>Not in File</Reprint><Start_Page>1458</Start_Page><End_Page>1463</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>35</Volume><Issue>12</Issue><ISSN_ISBN>1540-8159</ISSN_ISBN><Misc_3>10.1111/j.1540-8159.2012.03515.x</Misc_3><Address>Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation. sergei_mamchur@mail.ru</Address><Web_URL>PM:22978723</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(223)22978723 Assess the risk of AV block during ablation of parahisian ectopic foci prior to ablation by high-amplitude pace mapping. RCT (N=20)Ablation at site where high-amplitude (15-30 mA) pacing revealed absence of His capture (wide QRS complexes) (n=11)Ablation performed in conventional manner (n=9)Pts w/ parahisian ectopic foci (i.e., pts w/ focal JT) Pts w/ SHD Group 1: Ablation (standard approach) effective in 6/11 (55%); Group 2: Ablation effective w/ high amplitude pacing in 9/9 (100%),p=0.02Group 1: 27% AV block; Group 2: no complications,p=0.09Late recurrence of ectopic activity similar in both groups, p=NSGroup 1: Ablation effective in 6/11 (55%); Group 2: Ablation effective in 9/9 (100%),p=0.02. Group 1: 27% AV block; Group 2: no complications,p=0.09. Late recurrence of ectopic activity similar in both groups, p=NS. Small sample, generalizability unclear. Cannot use method for ectopic focus in right coronary sinus or the aorta.AV indicates atrioventricular; NS, non-significant; pt, patient; RCT, randomized controlled trial; SHD, structural heart disease; and w/, with.Data Supplement 19. Nonrandomized Trials, Observational Studies, and/or Registries of Junctional Tachycardia – Section 8StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsPharmacological TherapyRuder1986 ADDIN REFMGR.CITE <Refman><Cite><Author>Ruder</Author><Year>1986</Year><RecNum>310</RecNum><IDText>Clinical and electrophysiologic characterization of automatic junctional tachycardia in adults</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>310</Ref_ID><Title_Primary>Clinical and electrophysiologic characterization of automatic junctional tachycardia in adults</Title_Primary><Authors_Primary>Ruder,M.A.</Authors_Primary><Authors_Primary>Davis,J.C.</Authors_Primary><Authors_Primary>Eldar,M.</Authors_Primary><Authors_Primary>Abbott,J.A.</Authors_Primary><Authors_Primary>Griffin,J.C.</Authors_Primary><Authors_Primary>Seger,J.J.</Authors_Primary><Authors_Primary>Scheinman,M.M.</Authors_Primary><Date_Primary>1986/5</Date_Primary><Keywords>Adult</Keywords><Keywords>analysis</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electric Stimulation</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Exercise</Keywords><Keywords>Female</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Ventricles</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>pharmacology</Keywords><Keywords>physiopathology</Keywords><Keywords>Procainamide</Keywords><Keywords>Propranolol</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>930</Start_Page><End_Page>937</End_Page><Periodical>Circulation</Periodical><Volume>73</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Web_URL>PM:3698238</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(224)3698238Case reportn=55 adult pts w/ JT (one pt refused drug therapy)Control or eradication of arrhythmiaAll pts responded to beta-blockers (nadolol, propranolol), and best response w/ beta-blockers w/ procainamide.First report of JT in adults. Good response to beta-blockers. Only 4/5 pts underwent EP study to definitively identify junctional origin. Cook1988 ADDIN REFMGR.CITE <Refman><Cite><Author>Cook</Author><Year>1991</Year><RecNum>303</RecNum><IDText>An incessant form of junctional ectopic tachycardia in an adult responsive to a class 1C agent</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>303</Ref_ID><Title_Primary>An incessant form of junctional ectopic tachycardia in an adult responsive to a class 1C agent</Title_Primary><Authors_Primary>Cook,J.R.</Authors_Primary><Authors_Primary>Steinberg,J.S.</Authors_Primary><Date_Primary>1991/11</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Administration,Oral</Keywords><Keywords>Adult</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Flecainide</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Reprint>Not in File</Reprint><Start_Page>1487</Start_Page><End_Page>1489</End_Page><Periodical>Am Heart J</Periodical><Volume>122</Volume><Issue>5</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Address>Department of Medicine, Columbia-Presbyterian Medical Center, New York, N.Y</Address><Web_URL>PM:1951023</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(225)1951023Case reportn=119 y w/ refractory JTFlecainide therapy for JT refractory to AV nodal blockers, burst atrial or ventricular pacingFlecainide 150 mg bid successful in restoring SRFirst report of successful treatment of “incessant” JT w/ class Ic agent. Kuck1988PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Y2s8L0F1dGhvcj48WWVhcj4xOTg4PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Y2s8L0F1dGhvcj48WWVhcj4xOTg4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (226)3144166Case seriesn=316 total pts w/ ectopic atrial tachyarrhythmia in study, 2 spontaneous JT (not inducible), 1 incessant JTFlecainide and encainide therapy for JTFlecainide effective in 2 pts w/ spontaneous JT (200 and 300 mg/d). Pt w/ incessant JT had prolongation of H-V interval and hypotension.Encainide arm not valid for guidelines, but flecainide results valid for treatment of spontaneous JT. Builds on Cook’s data above.Villain1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Villain</Author><Year>1990</Year><RecNum>312</RecNum><IDText>Evolving concepts in the management of congenital junctional ectopic tachycardia. A multicenter study</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>312</Ref_ID><Title_Primary>Evolving concepts in the management of congenital junctional ectopic tachycardia. A multicenter study</Title_Primary><Authors_Primary>Villain,E.</Authors_Primary><Authors_Primary>Vetter,V.L.</Authors_Primary><Authors_Primary>Garcia,J.M.</Authors_Primary><Authors_Primary>Herre,J.</Authors_Primary><Authors_Primary>Cifarelli,A.</Authors_Primary><Authors_Primary>Garson,A.,Jr.</Authors_Primary><Date_Primary>1990/5</Date_Primary><Keywords>Amiodarone</Keywords><Keywords>Bundle of His</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>congenital</Keywords><Keywords>Digoxin</Keywords><Keywords>Drug Therapy,Combination</Keywords><Keywords>Echocardiography</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Multicenter Studies as Topic</Keywords><Keywords>Pacemaker,Artificial</Keywords><Keywords>Patients</Keywords><Keywords>Propranolol</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>1544</Start_Page><End_Page>1549</End_Page><Periodical>Circulation</Periodical><Volume>81</Volume><Issue>5</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Pediatrics, Baylor College of Medicine, Houston, Texas</Address><Web_URL>PM:2184944</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(227)2184944Multicenter study; pediatric population n=26Infants w/ JTAAD therapy in congenital JT, w/ success defined as HR <150 bpm, partial success as HR >150 bpm w/ sx reliefCombinations of digoxin, propranolol, amiodarone, quinidine, flecainide, chlorpromazine, phenytoin. 10 pts treated w/ amiodarone monotherapy —6 successes, 2 partial successes, 2 failures. One death in f/u. Amiodarone combination therapy less effective.Amiodarone monotherapy is effective for congenital JT, but associated w/ some mortality. Authors comment that ablation should be reserved for drug-refractory JT. Digoxin ineffective in rate control, and may be harmful--specifically, incriminated in producing VF in 4 wk old child; and atrial tachycardia and then atrial flutter in 10 d old infant.Paul1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Paul</Author><Year>1992</Year><RecNum>308</RecNum><IDText>Efficacy and safety of propafenone in congenital junctional ectopic tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>308</Ref_ID><Title_Primary>Efficacy and safety of propafenone in congenital junctional ectopic tachycardia</Title_Primary><Authors_Primary>Paul,T.</Authors_Primary><Authors_Primary>Reimer,A.</Authors_Primary><Authors_Primary>Janousek,J.</Authors_Primary><Authors_Primary>Kallfelz,H.C.</Authors_Primary><Date_Primary>1992/10</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>congenital</Keywords><Keywords>diagnosis</Keywords><Keywords>Drug Evaluation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrocardiography,Ambulatory</Keywords><Keywords>epidemiology</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Germany</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Propafenone</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time Factors</Keywords><Reprint>Not in File</Reprint><Start_Page>911</Start_Page><End_Page>914</End_Page><Periodical>J Am Coll Cardiol</Periodical><Volume>20</Volume><Issue>4</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>0735-1097(92)90192-P</Misc_3><Address>Children's Hospital, Hannover Medical School, Germany</Address><Web_URL>PM:1527301</Web_URL><ZZ_JournalFull><f name="System">Journal of the American College of Cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Am Coll Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(228)1527301Case series; pediatric populationn=4Infants w/ congenital JTPropafenone therapy for congenital JTEffective at restoring SR w/ doses of 300 mg/m2 w/ f/u ranging 1-36 moEfficacy of propafenone in pediatric population can avoid need for ablation in young population, and early toxicity of amiodarone.Heusch 1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhldXNjaDwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhldXNjaDwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (91)7527342Retrospective cohort study; pediatric populationn=372 pediatric pts w/ supraventricular arrhythmias treated w/ propafenone, only 3 pts had JTEfficacy of propafenone in suppressing supraventricular arrhythmiaSuccessful in 2/3 pts w/ JTSupports results of Paul et al for use of propafenone, despite small subset of pts w/ JT.Raja P1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhamE8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhamE8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (229)7946778 Retrospective cohort study; pediatric populationn=16Postoperative (CHD) JETEfficacy of amiodarone for rate controlMean HR of 200 bpm, reduced to mean 153-170 in 24-h f/uAmiodarone effective in HR and hemodynamic control for postoperative JT.Lee1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJlY051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 EN.CITE.DATA (230)10392383Prospective cohort studyn=17 (age 12-83)Pts developed JT during EP study, and all inducible w/ isoproterenolEffect of adenosine and verapamil in catecholamine-inducible JTAdenosine terminated rhythm in all pts, 11 w/ transient AV block. IV verapamil terminated rhythm in all 10 pts given the drugSupports treatment of JT due to enhanced automaticity w/ adenosine and verapamil. Presence of AV block w/ adenosine suggests differential effect on automaticity and AV conduction. Age range spans pediatric and adult. Sarubbi 2002 ADDIN REFMGR.CITE <Refman><Cite><Author>Sarubbi</Author><Year>2002</Year><RecNum>311</RecNum><IDText>Congenital junctional ectopic tachycardia in children and adolescents: a 20 year experience based study</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>311</Ref_ID><Title_Primary>Congenital junctional ectopic tachycardia in children and adolescents: a 20 year experience based study</Title_Primary><Authors_Primary>Sarubbi,B.</Authors_Primary><Authors_Primary>Musto,B.</Authors_Primary><Authors_Primary>Ducceschi,V.</Authors_Primary><Authors_Primary>D'Onofrio,A.</Authors_Primary><Authors_Primary>Cavallaro,C.</Authors_Primary><Authors_Primary>Vecchione,F.</Authors_Primary><Authors_Primary>Musto,C.</Authors_Primary><Authors_Primary>Calabro,R.</Authors_Primary><Date_Primary>2002/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Amiodarone</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>congenital</Keywords><Keywords>Digoxin</Keywords><Keywords>drug therapy</Keywords><Keywords>Drug Therapy,Combination</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Italy</Keywords><Keywords>Male</Keywords><Keywords>Propafenone</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>188</Start_Page><End_Page>190</End_Page><Periodical>Heart</Periodical><Volume>88</Volume><Issue>2</Issue><User_Def_5>PMC1767240</User_Def_5><ISSN_ISBN>1468-201X</ISSN_ISBN><Address>Second University of Naples, Division of Paediatric Cardiology, Monaldi Hospital, Naples, Italy. bsarubb@tin.it</Address><Web_URL>PM:12117855</Web_URL><ZZ_JournalFull><f name="System">Heart (British Cardiac Society)</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Heart</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(231)12117855Retrospective cohort studyn = 9, age 2-6 mo5/9 pts w/ family h/o JT; 6/9 w/ decreased ventricular functionEffects of digoxin, propafenone, amiodaroneDigoxin alone ineffective; propafenone alone effective in 2/9 pts; amiodarone in combination w/ propafenone or flecainide effective in 6 ptsDigoxin or propafenone alone ineffective; Amiodarone effective as part of combination therapy w/ propafenone; or flecainide; genetic contribution noted. Ablation TherapyScheinman MM1994 ADDIN REFMGR.CITE <Refman><Cite><Author>Scheinman</Author><Year>1994</Year><RecNum>99</RecNum><IDText>Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>99</Ref_ID><Title_Primary>Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia</Title_Primary><Authors_Primary>Scheinman,M.M.</Authors_Primary><Authors_Primary>Gonzalez,R.P.</Authors_Primary><Authors_Primary>Cooper,M.W.</Authors_Primary><Authors_Primary>Lesh,M.D.</Authors_Primary><Authors_Primary>Lee,R.J.</Authors_Primary><Authors_Primary>Epstein,L.M.</Authors_Primary><Date_Primary>1994/9/15</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Carotid Sinus</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>Massage</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>physiopathology</Keywords><Keywords>Prospective Studies</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Reprint>Not in File</Reprint><Start_Page>565</Start_Page><End_Page>572</End_Page><Periodical>Am J Cardiol</Periodical><Volume>74</Volume><Issue>6</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(94)90745-5</Misc_3><Address>Department of Medicine, University of California, San Francisco 94143-1354</Address><Web_URL>PM:8074039</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(232)8074039Case seriesn=8Adult pts w/ JTRFA of JT6/8 w/ JT underwent ablation, 2 underwent AVJ ablation. Only 2 w/ preserved AV conduction.Early report establishing that RF ablation may be successful therapy for JT.Hamdan M1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhbWRhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhbWRhbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA (233)8960595 Case seriesn=11Pts w/ JT (age 1-66)RFA of JTRFA successful w/o complications in 9/11 pts (82%). 7/9 successful w/ ablation at site of earliest atrial activation and 2 pts required empiric lesions in posteroseptal area due to lack of VA conduction. CHB developed in 1 pt, and RFA failed in 1 pt. F/u 1-20 mo.RF ablation a largely successful strategy in series of pts, half of which were adults. Law IH2006 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhdzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhdzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (234)16876738Retrospective cohort study; pediatric population n=6 (range 7-36 y, median 8 y)All pts who underwent cryoablation for symptomatic, non-postoperative JT, refractory to AADs (primarily beta-blockers), at 2 hospitals.Efficacy and safety of cryoablation for JT4 pts had no JT at end of procedure. All 5 pts who underwent procedure were free of JT on up to 2 y of f/u.Early report of cryoablation of JT, safe and effective (except w/ proximity to His-Purkinje system), and may confer long term benefit. This study studied a small number of primarily pediatric pts at two institutions. Pharmacologic therapy not attempted in all pts. One pt had an ectopic focus proximal to His-Purkinje, and cryomapping resulted in transient CHB, so cryoablation not performed.EP Study DiagnosisMeiltz A2006 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laWx0ejwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laWx0ejwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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ADDIN EN.CITE.DATA (235)16627404 Retrospective cohort, multicentern=49Adults w/ PJRT confirmed at EP study, both paroxysmal (53%) and incessantDescribe results of RFA in adults w/ PJRTRFA successful in 94% w/o complications, and long term success 100% w/o AADs, w/ 49 mo mean f/u. Rare report of PJRT in adults only, so results pertinent to guidelines, and support RF ablation as first line therapy. Padanilam BJ2006 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhZGFuaWxhbTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhZGFuaWxhbTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN EN.CITE.DATA (236)19007691Prospective cohort studyn=39Adults w/ AVNRT, JT, or “clinically indeterminate.” To distinguish JT or AVNRT based on specific responses to PACs delivered at different phases of the tachycardia cyclePACs introduced during His refractoriness did not affect tachycardia. Earlier PACs preexcite the immediate His and ventricle, w/o terminating tachycardia, confirming JT. For AVNRT, 61% sensitivity, 100% specificity; for JT, 100% sensitivity and specificity.The response to PACs during tachycardia can distinguish JT from AVNRT w/ 100% specificity and high sensitivity. However, PACs introduced during His refractoriness can lead to misdiagnosis of JT as AVNRT if dual AV nodal physiology is present. Furthermore, if double ventricular responses are present, a PAC during AVNRT can advance the His w/ continuation of the tachycardia, misdiagnosed as JT.Srivathsan K2007 ADDIN REFMGR.CITE <Refman><Cite><Author>Srivathsan</Author><Year>2008</Year><RecNum>105</RecNum><IDText>Differentiating atrioventricular nodal reentrant tachycardia from junctional tachycardia: novel application of the delta H-A interval</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>105</Ref_ID><Title_Primary>Differentiating atrioventricular nodal reentrant tachycardia from junctional tachycardia: novel application of the delta H-A interval</Title_Primary><Authors_Primary>Srivathsan,K.</Authors_Primary><Authors_Primary>Gami,A.S.</Authors_Primary><Authors_Primary>Barrett,R.</Authors_Primary><Authors_Primary>Monahan,K.</Authors_Primary><Authors_Primary>Packer,D.L.</Authors_Primary><Authors_Primary>Asirvatham,S.J.</Authors_Primary><Date_Primary>2008/1</Date_Primary><Keywords>diagnosis</Keywords><Keywords>Diagnosis,Differential</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Isoproterenol</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Reproducibility of Results</Keywords><Keywords>Sensitivity and Specificity</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Reprint>Not in File</Reprint><Start_Page>1</Start_Page><End_Page>6</End_Page><Periodical>J Cardiovasc Electrophysiol.</Periodical><Volume>19</Volume><Issue>1</Issue><ISSN_ISBN>1540-8167</ISSN_ISBN><Misc_3>JCE961;10.1111/j.1540-8167.2007.00961.x</Misc_3><Address>Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA</Address><Web_URL>PM:17916156</Web_URL><ZZ_JournalFull><f name="System">Journal of cardiovascular electrophysiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Cardiovasc Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(237)17916156Retrospective cohort studyn=35Typical AVNRT and evidence of JT during EP study and/or ablationTo assess the utility of delta H-A interval (difference in the H-A intervals observed during tachycardia and basal RV pacing to differentiate AVNRT and JT—delta HA = HA during pacing minus HA during tachycardia. (Helps to distinguish whether H-A interval represents true his conduction to the atria, or whether atria and His activated simultaneously from common focal source.)Average H-A interval was -10 msec during AVNRT and 9 msec during JT (p<0.00001). Delta HA ≥0 has sensitivity/specificity of 89%/83%, PPV/NPV 84%/88% for diagnosis of JT.Delta HA is a useful metric that can aid differentiation of AVNRT and JT during EP study. Utility in that JT ablation confers high risk of AV block. Limited in that spontaneous JT may be mechanistically different from JT seen w/ slow path modification. Fan R2011 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZhbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZhbjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (238)21220046 Prospective cohort studyn=21Adult pts referred to a single center for EP study and subsequent AVNRT ablation.To investigate whether the tachycardia response to atrial overdrive pacing at a CL shorter than the tachycardia CL can elucidate whether the tachycardia is JT or AVNRT. The paced AH interval was shorter for JT compared w/ AVNRT (86±19 msec vs. 338±59 msec, p<0.0001).The mean CL of JT longer compared w/ AVNRT (614±118 msec vs. 373±65 msec, p<0.0001)Atrial overdrive pacing during tachycardia can help to rapidly differentiate JT from AVNRT (transiently suppresses JT, entrains AVNRT). Diagnosis of JT made on clinical grounds, although JT only observed post-ablation. Potential for misdiagnosis of AVNRT as JT. Included only spontaneous JT after AVNRT ablation (excluded “clinical” JT, i.e. not due to AVNRT ablation).AAD indicates antiarrhythmic drug; AV, atrioventricular; AVJ, atrioventricular junction; AVNRT, atrioventricular nodal reentrant tachycardia; bid, two times per day; bpm, beats per min; CHB, complete heart block; CHD, congenital heart disease; CL, cycle length; EP, electrophysiological; f/u, follow up; h/o, history of; HR, heart rate; IV, intravenous; JET, junctional ectopic tachycardia; JT, junctional tachycardia; NPV, negative predictive value; PAC, premature atrial contractions; PJRT, permanent junctional reciprocating tachycardia; PPV, positive predictive value; pt, patient; RFA, radiofrequency ablation; SR, sinus rhythm; sx, symptom; VA, ventriculoatrial; VF, ventricular fibrillation; w/, with; and w/o, without. Data Supplement 20. Nonrandomized Trials, Observational Studies, and/or Registries of Special Populations – Section 9StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsPediatrics: Epidemiology Lundberg A1982 ADDIN REFMGR.CITE <Refman><Cite><Author>Lundberg</Author><Year>1982</Year><RecNum>255</RecNum><IDText>Paroxysmal atrial tachycardia in infancy: long-term follow-up study of 49 subjects</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>255</Ref_ID><Title_Primary>Paroxysmal atrial tachycardia in infancy: long-term follow-up study of 49 subjects</Title_Primary><Authors_Primary>Lundberg,A.</Authors_Primary><Date_Primary>1982/10</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>congenital</Keywords><Keywords>diagnosis</Keywords><Keywords>Disease</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>Time Factors</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>638</Start_Page><End_Page>642</End_Page><Periodical>Pediatrics</Periodical><Volume>70</Volume><Issue>4</Issue><ISSN_ISBN>0031-4005</ISSN_ISBN><Web_URL>PM:7122164</Web_URL><ZZ_JournalStdAbbrev><f name="System">Pediatrics</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(239)7122164Retrospective, single center4949 babies SVT in infancy, 40 SVT, 9 atrial flutter/AF 86% malesF/u mean 24 ySVT recurrence after infancyMales w/ WPW: 60% recurrence. Pts w/o WPW: 30% recurrenceRecurrent SVT after infant SVT: 30-60%Deal BJ1985PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4xOTg1PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4xOTg1PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (240)3964800Retrospective multicenter9090 babies WPW and SVT ≤4 mo of age. SHD 20%. AVRT, one atrial flutter, no AF. Mean f/u 6.5 y. WPW outcomes infants w/ SVTCardioversion success 87%, chronic digoxin 85 pts. Deaths: 4.4%, 2 w/o SHD: all receiving digoxin. One no SHD developed cardiomyopathy thought due to recurrent high dose cardioversions. Mortality 4.4%, (2 no SHD), all receiving digoxin. 1/3 pts developing wide QRS tachycardia died. Perry JC 1990PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlcnJ5PC9BdXRob3I+PFllYXI+MTk5MDwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlcnJ5PC9BdXRob3I+PFllYXI+MTk5MDwvWWVhcj48UmVj
TnVtPjI1NjwvUmVjTnVtPjxJRFRleHQ+U3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYSBkdWUg
dG8gV29sZmYtUGFya2luc29uLVdoaXRlIHN5bmRyb21lIGluIGNoaWxkcmVuOiBlYXJseSBkaXNh
cHBlYXJhbmNlIGFuZCBsYXRlIHJlY3VycmVuY2U8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3Vy
bmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4yNTY8L1JlZl9JRD48VGl0
bGVfUHJpbWFyeT5TdXByYXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhIGR1ZSB0byBXb2xmZi1QYXJr
aW5zb24tV2hpdGUgc3luZHJvbWUgaW4gY2hpbGRyZW46IGVhcmx5IGRpc2FwcGVhcmFuY2UgYW5k
IGxhdGUgcmVjdXJyZW5jZTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlBlcnJ5LEou
Qy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdhcnNvbixBLixKci48L0F1dGhv
cnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5PjE5OTAvMTE8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+
QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uPC9L
ZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlhYyBQYWNpbmcsQXJ0aWZpY2lhbDwvS2V5d29yZHM+PEtl
eXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXRoZXRlcml6YXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkLFByZXNjaG9v
bDwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5j
b25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+ZGlhZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+RWxlY3Ryb2NhcmRpb2dyYXBoeTwvS2V5d29yZHM+PEtleXdvcmRzPmV0aW9sb2d5PC9LZXl3
b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+Rm9sbG93LVVwIFN0dWRp
ZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IENv
bmR1Y3Rpb24gU3lzdGVtPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgRGVmZWN0cyxDb25nZW5p
dGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SW5mYW50
PC9LZXl3b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPk1lZGljaW5lPC9L
ZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRo
b2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+
VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxTdXByYXZlbnRyaWN1
bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+VGltZSBGYWN0b3JzPC9LZXl3b3Jkcz48S2V5d29yZHM+
V29sZmYtUGFya2luc29uLVdoaXRlIFN5bmRyb21lPC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4g
RmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4xMjE1PC9TdGFydF9QYWdlPjxFbmRfUGFnZT4xMjIw
PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5KIEFtIENvbGwgQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9s
dW1lPjE2PC9Wb2x1bWU+PElzc3VlPjU8L0lzc3VlPjxJU1NOX0lTQk4+MDczNS0xMDk3PC9JU1NO
X0lTQk4+PE1pc2NfMz4wNzM1LTEwOTcoOTApOTA1NTUtNDwvTWlzY18zPjxBZGRyZXNzPlNlY3Rp
b24gb2YgUGVkaWF0cmljIENhcmRpb2xvZ3ksIEJheWxvciBDb2xsZWdlIG9mIE1lZGljaW5lLCBU
ZXhhcyBDaGlsZHJlbiZhcG9zO3MgSG9zcGl0YWwsIEhvdXN0b24gNzcwMzA8L0FkZHJlc3M+PFdl
Yl9VUkw+UE06MjIyOTc2OTwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVt
Ij5Kb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBDb2xsZWdlIG9mIENhcmRpb2xvZ3k8L2Y+PC9aWl9K
b3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkogQW0gQ29s
bCBDYXJkaW9sPC9mPjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9X
b3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN EN.CITE.DATA (241)2229769Retrospective, single center140140 pts WPW w/ SVT <18 y old. CHD 37%--23% of CHD = Ebstein’s. Multiple AC: 12%. SVT recurrences vs. age w WPWSVT age ≤2 mo: 31% recurrent SVT, average age 8 y. SVT > age 5 y: 78% recurrent SVT during mean f/u 7 y. SVT recurs more frequently in pts w/ first episode ≥ age 5 y. Wu MH1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPld1PC9BdXRob3I+PFllYXI+MTk5NDwvWWVhcj48UmVjTnVt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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPld1PC9BdXRob3I+PFllYXI+MTk5NDwvWWVhcj48UmVjTnVt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ADDIN EN.CITE.DATA (242)7850817Retrospective, single center9090 pts w/ SVT <15 y old, median f/u 215 mo. CHF 16%. Stroke 1 pt.Recurrent SVT vs. age onset SVTSVT age 1-5 y: 40% recurrent SVT prenatal SVT lowest risk recurrent SVT, followed by age <1 y, then 1-5 y; onset >5 y highest risk. First SVT ≥5 y: highest risk for recurrent SVT vs. age 1-5 y, or age <1 y Riggs TW 1999 ADDIN REFMGR.CITE <Refman><Cite><Author>Riggs</Author><Year>1999</Year><RecNum>257</RecNum><IDText>Recurrence risk of supraventricular tachycardia in pediatric patients</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>257</Ref_ID><Title_Primary>Recurrence risk of supraventricular tachycardia in pediatric patients</Title_Primary><Authors_Primary>Riggs,T.W.</Authors_Primary><Authors_Primary>Byrd,J.A.</Authors_Primary><Authors_Primary>Weinhouse,E.</Authors_Primary><Date_Primary>1999</Date_Primary><Keywords>Adolescent</Keywords><Keywords>analysis</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrocardiography,Ambulatory</Keywords><Keywords>epidemiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Male</Keywords><Keywords>Michigan</Keywords><Keywords>Odds Ratio</Keywords><Keywords>Patients</Keywords><Keywords>Pregnancy</Keywords><Keywords>Recurrence</Keywords><Keywords>Regression Analysis</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Survival Analysis</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>25</Start_Page><End_Page>30</End_Page><Periodical>Cardiology</Periodical><Volume>91</Volume><Issue>1</Issue><ISSN_ISBN>0008-6312</ISSN_ISBN><Misc_3>6873;6873</Misc_3><Address>Department of Cardiology, University of Michigan Medical School, Ann Arbor, Mich., USA</Address><Web_URL>PM:10393395</Web_URL><ZZ_JournalStdAbbrev><f name="System">Cardiology</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(243)10393395Retrospective, single center7070 pediatric pts w/ SVT, vs. WPW and age.Recurrent SVT: 29% w/ SVT <1 y, vs. 94% w/ SVT onset >1 y. Risk recurrent SVT in young ptsOnly sig predictor of recurrent SVT was age at presentationWPW not significant multivariate. 11First SVT after age 1 y: high likelihood recurrent SVT vs. onset SVT <1 y (OR: 34.6). Tortoriello TA2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRvcnRvcmllbGxvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVh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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRvcnRvcmllbGxvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVh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=
ADDIN EN.CITE.DATA (244)14583354Retrospective, single center150All pts SVT <1 y 1/1984-12/00. Risk recurrent SVT in young pts vs. preexcitationPts w/ preexcitation: 88% recurrent SVT, vs. 17% w/o WPW. WPW pts more likely to require multiple drugs.Presence of WPW associated w/ increased risk recurrent SVTGilljam T2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpbGxqYW08L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
ZWNOdW0+MjU0PC9SZWNOdW0+PElEVGV4dD5OZW9uYXRhbCBzdXByYXZlbnRyaWN1bGFyIHRhY2h5
Y2FyZGlhOiBvdXRjb21lcyBvdmVyIGEgMjcteWVhciBwZXJpb2QgYXQgYSBzaW5nbGUgaW5zdGl0
dXRpb248L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwv
UmVmX1R5cGU+PFJlZl9JRD4yNTQ8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5OZW9uYXRhbCBzdXBy
YXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhOiBvdXRjb21lcyBvdmVyIGEgMjcteWVhciBwZXJpb2Qg
YXQgYSBzaW5nbGUgaW5zdGl0dXRpb248L1RpdGxlX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5H
aWxsamFtLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5KYWVnZ2ksRS48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdvdyxSLk0uPC9BdXRob3JzX1ByaW1hcnk+
PERhdGVfUHJpbWFyeT4yMDA4Lzg8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwv
S2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+YW5hbHlzaXM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+QXJyaHl0aG1pYXMsQ2FyZGlhYzwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkLFByZXNjaG9v
bDwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRzPkVs
ZWN0cm9jYXJkaW9ncmFwaHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5lcGlkZW1pb2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb2xsb3ctVXAgU3R1ZGll
czwvS2V5d29yZHM+PEtleXdvcmRzPkhlYWx0aCBTdGF0dXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5I
ZWFydCBSYXRlPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+
SW5mYW50PC9LZXl3b3Jkcz48S2V5d29yZHM+SW5mYW50LE5ld2Jvcm48L0tleXdvcmRzPjxLZXl3
b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+TWFzcyBTY3JlZW5pbmc8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+TXVsdGl2YXJpYXRlIEFuYWx5c2lz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9s
b2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVj
dXJyZW5jZTwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNr
IEZhY3RvcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+
VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxTdXByYXZlbnRyaWN1
bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFwZXV0aWMgdXNlPC9LZXl3b3Jkcz48UmVwcmlu
dD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4xMDM1PC9TdGFydF9QYWdlPjxFbmRf
UGFnZT4xMDM5PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5BY3RhIFBhZWRpYXRyLjwvUGVyaW9kaWNh
bD48Vm9sdW1lPjk3PC9Wb2x1bWU+PElzc3VlPjg8L0lzc3VlPjxJU1NOX0lTQk4+MDgwMy01MjUz
PC9JU1NOX0lTQk4+PE1pc2NfMz5BUEE4MjM7MTAuMTExMS9qLjE2NTEtMjIyNy4yMDA4LjAwODIz
Lng8L01pc2NfMz48QWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBUaGUgSG9zcGl0YWwg
Zm9yIFNpY2sgQ2hpbGRyZW4sIFRoZSBVbml2ZXJzaXR5IG9mIFRvcm9udG8sIFRvcm9udG8sIE9u
dGFyaW8sIENhbmFkYS4gdGhvbWFzLmdpbGxqYW1AdmdyZWdpb24uc2U8L0FkZHJlc3M+PFdlYl9V
Ukw+UE06MTg0ODk2MjE8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+
QWN0YSBwYWVkaWF0cmljYSAoT3NsbywgTm9yd2F5IDogMTk5Mik8L2Y+PC9aWl9Kb3VybmFsRnVs
bD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkFjdGEgUGFlZGlhdHIuPC9m
PjwvWlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwv
TURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpbGxqYW08L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (245)18489621 Retrospective, single center109109 pts SVT <30 d, 1971-1997. SVT = AVRT or AVNRTOutcomes neonatal SVTFreedom from arrhythmia: 52% 1 y, 82% 5 y, 83% 10 y. Recurrence 31% WPW vs. 6% no overt WPW. Mortality 2.7% related to arrhythmia/CHF. Recurrences higher overt WPW, multiple meds, or >6 d to obtain initial arrhythmia control. Santinelli V2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbnRpbmVsbGk8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (246)19147045Prospective, single center1841995-2005, 184 pts ≤12 y (median 10 y, 8-12 y) w/ asymptomatic WPW evaluated and followed, median 57 mo. Natural h/o asymptomatic WPW in children 72% remained asymptomatic. 28% sxs: 10% considered “POTS life-threatening”: cardiac arrest 1.6%; Syncope 1.6%Cardiac arrest 1.6%Multivariate risk: APERP ≤240 msec (p=.001)And multiple AC (p= .001)Salerno JC2011 ADDIN REFMGR.CITE <Refman><Cite><Author>Salerno</Author><Year>2011</Year><RecNum>258</RecNum><IDText>Case fatality in children with supraventricular tachycardia in the United States</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>258</Ref_ID><Title_Primary>Case fatality in children with supraventricular tachycardia in the United States</Title_Primary><Authors_Primary>Salerno,J.C.</Authors_Primary><Authors_Primary>Garrison,M.M.</Authors_Primary><Authors_Primary>Larison,C.</Authors_Primary><Authors_Primary>Seslar,S.P.</Authors_Primary><Date_Primary>2011/7</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>analysis</Keywords><Keywords>Cardiomyopathies</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>diagnosis</Keywords><Keywords>Disease</Keywords><Keywords>epidemiology</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Hospitalization</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Prognosis</Keywords><Keywords>Regression Analysis</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>United States</Keywords><Keywords>Young Adult</Keywords><Reprint>Not in File</Reprint><Start_Page>832</Start_Page><End_Page>836</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>34</Volume><Issue>7</Issue><ISSN_ISBN>1540-8159</ISSN_ISBN><Misc_3>10.1111/j.1540-8159.2011.03073.x</Misc_3><Address>Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington 98105, USA. jack.salerno@</Address><Web_URL>PM:21418251</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(247) HYPERLINK "" 21418251Retrospective multi-center review1755Reviewed hospital databases 41 children’s hospitals between 1/03-9/08Discharge dx SVT, age <25 y Case fatalityOverall 68 deaths (4%)6% w/ SHD died vs. 1% of pts w/o SHDCase fatality increased in:Age <1 mo, OR: 2.41 (95% CI: 1.35-4.32)SHD, OR: 2.67 (95% CI: 1.22-5.80)Cardiomyopathy, OR: 6.72 (95% CI: 1.79-25.28) regardless of SHDCase fatality in absence of SHD is low, 1%, Vs. 6% in presence of SHDCase fatality highest in cardiomyopathy regardless of presence of SHDCain N2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Cain</Author><Year>2013</Year><RecNum>30</RecNum><IDText>Natural history of Wolff-Parkinson-White syndrome diagnosed in childhood</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>30</Ref_ID><Title_Primary>Natural history of Wolff-Parkinson-White syndrome diagnosed in childhood</Title_Primary><Authors_Primary>Cain,N.</Authors_Primary><Authors_Primary>Irving,C.</Authors_Primary><Authors_Primary>Webber,S.</Authors_Primary><Authors_Primary>Beerman,L.</Authors_Primary><Authors_Primary>Arora,G.</Authors_Primary><Date_Primary>2013/10/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Asymptomatic Diseases</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>complications</Keywords><Keywords>Death,Sudden,Cardiac</Keywords><Keywords>diagnosis</Keywords><Keywords>Disease Progression</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>mortality</Keywords><Keywords>physiopathology</Keywords><Keywords>Remission,Spontaneous</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>961</Start_Page><End_Page>965</End_Page><Periodical>Am J Cardiol</Periodical><Volume>112</Volume><Issue>7</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(13)01233-2;10.1016/j.amjcard.2013.05.035</Misc_3><Address>Medical University of South Carolina, Charleston, South Carolina. Electronic address: cainn@musc.edu</Address><Web_URL>PM:23827401</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(21)23827401Retrospective, single center446446 pts WPW; median age dx 7 y, 61% male, 9% SHD. Presentation: 64% w/ sxs--SVT 38%; chest pain or palps 27%; syncope 4%, AF 0.4%; cardiac arrest 0.2%. Natural h/o WPWDuring f/u: additional 20% developed sx. 54% SVT, AF 1.6%. Pts dx ≤3 mo, 35% WPW resolved, vs. 5.8% dx >3 mo. Sudden death 1.3%, 2.8/1000 pt y. Sudden death: 1.3%No heart disease: 1.1/1000 pt ySHD: 27/1000 pt y.Pediatrics: Mechanisms of SVTGarson A 1981 ADDIN REFMGR.CITE <Refman><Cite><Author>Garson</Author><Year>1981</Year><RecNum>264</RecNum><IDText>Electrophysiologic studies of supraventricular tachycardia in children. I. Clinical-electrophysiologic correlations</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>264</Ref_ID><Title_Primary>Electrophysiologic studies of supraventricular tachycardia in children. I. Clinical-electrophysiologic correlations</Title_Primary><Authors_Primary>Garson,A.,Jr.</Authors_Primary><Authors_Primary>Gillette,P.C.</Authors_Primary><Date_Primary>1981/8</Date_Primary><Keywords>abnormalities</Keywords><Keywords>Adolescent</Keywords><Keywords>Atrioventricular Node</Keywords><Keywords>Catheterization</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>complications</Keywords><Keywords>congenital</Keywords><Keywords>diagnosis</Keywords><Keywords>Digoxin</Keywords><Keywords>Disease</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Heart</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prognosis</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Sinoatrial Node</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>233</Start_Page><End_Page>250</End_Page><Periodical>Am Heart J</Periodical><Volume>102</Volume><Issue>2</Issue><ISSN_ISBN>0002-8703</ISSN_ISBN><Misc_3>S0002-8703(81)80015-4</Misc_3><Web_URL>PM:7258098</Web_URL><ZZ_JournalFull><f name="System">American heart journal</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am Heart J</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(248)7258098Retrospective, single center103Intracardiac EP study in pts 2 d-17 y, mean 4.2 y. Determine mechanisms of SVT in young pts w/ clinical SVTAVRT 50%, AVNRT 24%, AT 21%55% of AP tachycardia w/ manifest WPWPredominance of AP mediated tachycardia in young pts Ko JK1992 ADDIN REFMGR.CITE <Refman><Cite><Author>Ko</Author><Year>1992</Year><RecNum>266</RecNum><IDText>Supraventricular tachycardia mechanisms and their age distribution in pediatric patients</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>266</Ref_ID><Title_Primary>Supraventricular tachycardia mechanisms and their age distribution in pediatric patients</Title_Primary><Authors_Primary>Ko,J.K.</Authors_Primary><Authors_Primary>Deal,B.J.</Authors_Primary><Authors_Primary>Strasburger,J.F.</Authors_Primary><Authors_Primary>Benson,D.W.,Jr.</Authors_Primary><Date_Primary>1992/4/15</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Age Distribution</Keywords><Keywords>Age Factors</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>Disease</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Probability</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>1028</Start_Page><End_Page>1032</End_Page><Periodical>Am J Cardiol</Periodical><Volume>69</Volume><Issue>12</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Address>Department of Pediatrics, Northwestern University Children's Memorial Hospital, Chicago, Illinois</Address><Web_URL>PM:1561973</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(249)1561973Retrospective, single center137EP study (TEP 110, intracardiac 14, both 13) performed in pts <18 y of age, excluding significant heart disease or neuromuscular disordersDetermine mechanism of SVT in young pts w/ clinical SVTAVRT 73%, AT 14%, AVNRT 13%.AVNRT rarely present <2 y of age; AVRT and AT occurred throughout childhoodWeindling SN1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlaW5kbGluZzwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlaW5kbGluZzwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN EN.CITE.DATA (250)8554021Retrospective, single center112SVT in infants, 7/85-3/93. Mechanism of SVT in infants w/ SVTAVRT 77%, AVNRT 9%, Atrial reentry 10%, ectopic atrial 4%. 106 pts treated: 70% digoxin, propranolol, or both, Class I or III used in 12% each. 8% ablation failed med rx: 1/9 died related to ablation (VF after discharge). Overall mortality 4.4%, 4/5 w/ SHD. Ablation for medically refractory SVT. Neonate w/o SHD died related to complications of ablation.Recommends ablation for rare infants: fail aggressive med rx, rx comp by ventricular dysfunction, severe sx, complex SHD. Gross GJ 1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Gross</Author><Year>1998</Year><RecNum>265</RecNum><IDText>Characteristics, management, and midterm outcome in infants with atrioventricular nodal reentry tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>265</Ref_ID><Title_Primary>Characteristics, management, and midterm outcome in infants with atrioventricular nodal reentry tachycardia</Title_Primary><Authors_Primary>Gross,G.J.</Authors_Primary><Authors_Primary>Epstein,M.R.</Authors_Primary><Authors_Primary>Walsh,E.P.</Authors_Primary><Authors_Primary>Saul,J.P.</Authors_Primary><Date_Primary>1998/10/15</Date_Primary><Keywords>Adrenergic beta-Antagonists</Keywords><Keywords>Adult</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Boston</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Digoxin</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>956</Start_Page><End_Page>960</End_Page><Periodical>Am J Cardiol</Periodical><Volume>82</Volume><Issue>8</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002-9149(98)00512-8</Misc_3><Address>Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA</Address><Web_URL>PM:9794351</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(251)9794351Retrospective, single center15Infants AVNRT <1 y mean age 58 d, 5/15 after CHD palliation. Typical AVNRT 14/15. Mean f/u 45 mo. Outcome of AVNRT in first y of lifeDigoxin: 87%, successful 38%. 40% digoxin + propranolol, successful 4/6. Class III in 3 pts: 2/3 RFA: ages 4.1 and 6.7 y. All pts alive and well, minority syx beyond infancy. Digoxin questionalble benefit. AVNRT remained inducible in asymptomatic pts. Anand RG2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuYW5kPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuYW5kPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (252)19925541Retrospective, multicenter3556Registry of pediatric EP reviewed for pts undergoing ablation for SVT between 1999-2004.Ages <7 y: 378; 7-12: 964; 12-21 y: 2214; males 55%; white 82%Assess influence of age, gender, ethnicity on SVTAP: 68%; decreased w/ increasing ageAVNRT 32%In age 12-21 y, females more likely to have AVNRT than APBlack and Hispanic pts had less SVT than representation in population; whites more SVT than population. Proportion of SVT due to AP decreases w/ increasing age.After age 12 y, females more likely to have AVNRT than males. More whites in registry than expected based on population. Brembilla Perrot2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDEz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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDEz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ADDIN EN.CITE.DATA (253)23609066Retrospective, single center140Sxs of palpitations/SVT w/ normal ECG, underwent transesophageal pacing. Mean age 15±3 yUtility of TEP to identify SVT in pts w/o preexcitation59% AVNRT, AVRT 37%, AT 0.7%, VT 3%. High risk antegrade conduction over AP >240 bpm baseline or >290 bpm isoproterenol found in 1.4%.Preexcitation found in 13.5% w/ atrial pacing. Pediatrics: SVT Pharmacological TherapyPfammatter JP1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Pfammatter</Author><Year>1998</Year><RecNum>272</RecNum><IDText>Re-entrant supraventricular tachycardia in infancy: current role of prophylactic digoxin treatment</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>272</Ref_ID><Title_Primary>Re-entrant supraventricular tachycardia in infancy: current role of prophylactic digoxin treatment</Title_Primary><Authors_Primary>Pfammatter,J.P.</Authors_Primary><Authors_Primary>Stocker,F.P.</Authors_Primary><Date_Primary>1998/2</Date_Primary><Keywords>analysis</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Cardiology</Keywords><Keywords>complications</Keywords><Keywords>Digoxin</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Male</Keywords><Keywords>Patients</Keywords><Keywords>prevention & control</Keywords><Keywords>Recurrence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Failure</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>101</Start_Page><End_Page>106</End_Page><Periodical>Eur J Pediatr.</Periodical><Volume>157</Volume><Issue>2</Issue><ISSN_ISBN>0340-6199</ISSN_ISBN><Address>Paediatric Cardiology, Children's Hospital, Freiburgstrasse, Berne, Switzerland</Address><Web_URL>PM:9504781</Web_URL><ZZ_JournalFull><f name="System">European journal of pediatrics</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur J Pediatr.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(254)9504781Retrospective single center26SVT in infants <4 mo of ageMean age presentation 7 dSHD 31%; WPW 35%All AVRTDigoxin for neonatal SVTDigoxin successful: 65%Failure 27%Mean f/u 54 mo, 73% no meds no recurrences; 8% recurrent SVTDigoxin success 65%73% no early recurrences8% symptomatic recurrencesVillain E 1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZpbGxhaW48L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZpbGxhaW48L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (255)10223132Retrospective single center141SVT <1 y of age, 77% <1 mo. Digoxin first med in 114 pts, 81%; Amiodarone used after failure of digoxin (combo: 26%) or first: 19%. (solo 16%). Infant SVT: digoxin and amiodarone outcomesDigoxin effective 65%; amiodarone 97%. Total amiodarone used in 58 pts, no pro-arrhythmia, increase TSH 10%. . Adverse events 6 pts w/ digoxin: VF in 3 ptsDigoxin: VF in 3 pts, (2/3 WPW) in hospital; one additional baby died at 3 mo, digoxin, no SHD. Total 4 CA on digoxin: 3.5%. Amiodarone safer, more effective than digoxin. Losek JD 1999 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxvc2VrPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxvc2VrPC9BdXRob3I+PFllYXI+MTk5OTwvWWVhcj48UmVj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=
ADDIN EN.CITE.DATA (256)9922414Multicenter prospective and retrospective 8282 pts w/ 95 episodes SVT ≤18 y, in pediatric ED. 25 episodes <1 y of age. 10% SHD. Adenosine doses: low 0.1 mg/kg, medium 0.1-0.2 mg/kg, high ≥0.3 mg/kg. Adenosine for pediatric SVTAdenosine success 72%; AV node-dependent SVT success 79%. Successful dose: low 6%, medium 62%, high 32%. Adenosine cardioversion 72%; low dose rarely effective. Dixon J2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Dixon</Author><Year>2005</Year><RecNum>270</RecNum><IDText>Guidelines and adenosine dosing in supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>270</Ref_ID><Title_Primary>Guidelines and adenosine dosing in supraventricular tachycardia</Title_Primary><Authors_Primary>Dixon,J.</Authors_Primary><Authors_Primary>Foster,K.</Authors_Primary><Authors_Primary>Wyllie,J.</Authors_Primary><Authors_Primary>Wren,C.</Authors_Primary><Date_Primary>2005/11</Date_Primary><Keywords>Adenosine</Keywords><Keywords>administration & dosage</Keywords><Keywords>Adolescent</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>Dose-Response Relationship,Drug</Keywords><Keywords>Drug Administration Schedule</Keywords><Keywords>drug therapy</Keywords><Keywords>Great Britain</Keywords><Keywords>Guidelines</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Practice Guidelines as Topic</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>1190</Start_Page><End_Page>1191</End_Page><Periodical>Arch.Dis Child</Periodical><Volume>90</Volume><Issue>11</Issue><User_Def_5>PMC1720194</User_Def_5><ISSN_ISBN>1468-2044</ISSN_ISBN><Misc_3>90/11/1190;10.1136/adc.2005.077636</Misc_3><Address>Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, UK</Address><Web_URL>PM:16243875</Web_URL><ZZ_JournalFull><f name="System">Archives of disease in childhood</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Arch.Dis Child</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(257)16243875Retrospective single center35SVT rx w/ adenosine 1/98-5/03. 53 episodes. 23 infants, 12 children <16 y. Dosing of adenosine to terminate SVTAdenosine efficacy vs. dose: Infants: 50 mcg/kg, 9%, 150 mcg/kg, 35%; median effective 200 mcg/kg. Children: 50 mcg/kg: 9%,100 mcg/kg: <50%. median effective dose 150 mcg/kgAdenosine in recommended dose has low efficacy, <10%. Recommend minimum dose 100 mcg/kg children, 150-200 mcg/kg infants. Chang PM 2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoYW5nPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoYW5nPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj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 EN.CITE.DATA (258)20194798Retrospective single center37Refractory SVT: 40 episodes, 37 pts. 7/04-8/06. Median 34 d, 0-19 y. 65 SHD. IV procainamide: 50, Amiodarone 158 pts. AVRT 11, IART 18, EAT 11. Median dose amiodarone 2.5 mg/kg; procainamide 10 mg/kg.IV procainamide vs. amiodarone for terminating SV12Success: full + partial: Procainamide 71%, amiodarone 34%. Full success, Procainamide 50%, amiodarone 15%. IV procainamide more efficacious than IV amiodarone for acute termination of SVTDiza-Parra S 2014 ADDIN REFMGR.CITE <Refman><Cite><Author>Diaz-Parra</Author><Year>2014</Year><RecNum>269</RecNum><IDText>Use of adenosine in the treatment of supraventricular tachycardia in a pediatric emergency department</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>269</Ref_ID><Title_Primary>Use of adenosine in the treatment of supraventricular tachycardia in a pediatric emergency department</Title_Primary><Authors_Primary>Diaz-Parra,S.</Authors_Primary><Authors_Primary>Sanchez-Yanez,P.</Authors_Primary><Authors_Primary>Zabala-Arguelles,I.</Authors_Primary><Authors_Primary>Picazo-Angelin,B.</Authors_Primary><Authors_Primary>Conejo-Munoz,L.</Authors_Primary><Authors_Primary>Cuenca-Peiro,V.</Authors_Primary><Authors_Primary>Duran-Hidalgo,I.</Authors_Primary><Authors_Primary>Garcia-Soler,P.</Authors_Primary><Date_Primary>2014/6</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Cardiology</Keywords><Keywords>Cardiovascular Diseases</Keywords><Keywords>Disease</Keywords><Keywords>Emergencies</Keywords><Keywords>Guidelines</Keywords><Keywords>Heart</Keywords><Keywords>Incidence</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Spain</Keywords><Keywords>Tachycardia</Keywords><Reprint>Not in File</Reprint><Start_Page>388</Start_Page><End_Page>393</End_Page><Periodical>Pediatr.Emerg.Care</Periodical><Volume>30</Volume><Issue>6</Issue><ISSN_ISBN>1535-1815</ISSN_ISBN><Misc_3>10.1097/PEC.0000000000000144</Misc_3><Address>From the *Department for Critical Care and Emergencies, and daggerPediatric Cardiology Unit, Heart and Cardiovascular Diseases Department, Department of Pediatrics, Hospital Regional Universitario Carlos Haya, Malaga, Spain</Address><Web_URL>PM:24849273</Web_URL><ZZ_JournalFull><f name="System">Pediatric emergency care</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pediatr.Emerg.Care</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(259)24849273Retrospective, single center26Ped ED: 44 episodes SVT in 26 pts, mean age 3.1 y. 1/07-12/11. Adenosine given to 89%, increasing dosages. Efficacy of adenosine pediatric SVTAdenosine efficacy 75%. 30% responded to single dose, mean 112 mcg/kg; 41% 2 doses, mean response dose 188 mcg/kg; 24% 3 doses, mean response dose 249 mcg/kg. 66% discharged home. Mean effective dose of adenosine 173 mcg/kgm, higher than usual recommended dose. Mean number doses 1.7. Pediatrics: JET Risk FactorsBatra AS2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdHJhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdHJhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj
TnVtPjI3NDwvUmVjTnVtPjxJRFRleHQ+QSBwcm9zcGVjdGl2ZSBhbmFseXNpcyBvZiB0aGUgaW5j
aWRlbmNlIGFuZCByaXNrIGZhY3RvcnMgYXNzb2NpYXRlZCB3aXRoIGp1bmN0aW9uYWwgZWN0b3Bp
YyB0YWNoeWNhcmRpYSBmb2xsb3dpbmcgc3VyZ2VyeSBmb3IgY29uZ2VuaXRhbCBoZWFydCBkaXNl
YXNlPC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1Jl
Zl9UeXBlPjxSZWZfSUQ+Mjc0PC9SZWZfSUQ+PFRpdGxlX1ByaW1hcnk+QSBwcm9zcGVjdGl2ZSBh
bmFseXNpcyBvZiB0aGUgaW5jaWRlbmNlIGFuZCByaXNrIGZhY3RvcnMgYXNzb2NpYXRlZCB3aXRo
IGp1bmN0aW9uYWwgZWN0b3BpYyB0YWNoeWNhcmRpYSBmb2xsb3dpbmcgc3VyZ2VyeSBmb3IgY29u
Z2VuaXRhbCBoZWFydCBkaXNlYXNlPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QmF0
cmEsQS5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2h1bixELlMuPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Kb2huc29uLFQuUi48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5Pk1hbGRvbmFkbyxFLk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5LYXNoeWFwLEIuQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
Pk1haWVycyxKLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGluZGJsYWRlLEMu
TC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJvZGVmZWxkLE0uPC9BdXRob3Jz
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Ccm93bixKLlcuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5IdWJiYXJkLEouRS48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5
PjIwMDYvMTwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5hYm5vcm1hbGl0aWVzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48
S2V5d29yZHM+YW5hbHlzaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5ibG9vZDwvS2V5d29yZHM+PEtl
eXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9wdWxtb25hcnkgQnlw
YXNzPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2hpbGQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZCxQ
cmVzY2hvb2w8L0tleXdvcmRzPjxLZXl3b3Jkcz5jb25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29y
ZHM+Q3Jvc3MtU2VjdGlvbmFsIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5EaXNlYXNlPC9L
ZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb2NhcmRpb2dyYXBoeTwvS2V5d29yZHM+PEtleXdvcmRz
PkVsZWN0cm9seXRlczwvS2V5d29yZHM+PEtleXdvcmRzPmVwaWRlbWlvbG9neTwvS2V5d29yZHM+
PEtleXdvcmRzPmV0aW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48
S2V5d29yZHM+Rm9sbG93LVVwIFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5
d29yZHM+PEtleXdvcmRzPkhlYXJ0IERlZmVjdHMsQ29uZ2VuaXRhbDwvS2V5d29yZHM+PEtleXdv
cmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluY2lkZW5jZTwvS2V5d29yZHM+PEtleXdv
cmRzPkluZmFudDwvS2V5d29yZHM+PEtleXdvcmRzPkluZmFudCxOZXdib3JuPC9LZXl3b3Jkcz48
S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPk1lZGljaW5lPC9LZXl3b3Jkcz48S2V5
d29yZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5NdWx0aXZhcmlhdGUgQW5hbHlz
aXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NeW9jYXJkaWFsIENvbnRyYWN0aW9uPC9LZXl3b3Jkcz48
S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9sb2d5PC9LZXl3b3Jk
cz48S2V5d29yZHM+cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UG9zdG9wZXJh
dGl2ZSBDb21wbGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1ZGll
czwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrIEZhY3Rv
cnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdGF0aXN0aWNzICZhbXA7IG51bWVyaWNhbCBkYXRhPC9L
ZXl3b3Jkcz48S2V5d29yZHM+U3RhdGlzdGljcyBhcyBUb3BpYzwvS2V5d29yZHM+PEtleXdvcmRz
PnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdv
cmRzPlRhY2h5Y2FyZGlhLEVjdG9waWMgSnVuY3Rpb25hbDwvS2V5d29yZHM+PEtleXdvcmRzPnRo
ZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lPC9LZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4g
RmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT41MTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+NTU8L0Vu
ZF9QYWdlPjxQZXJpb2RpY2FsPlBlZGlhdHIuQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjI3
PC9Wb2x1bWU+PElzc3VlPjE8L0lzc3VlPjxJU1NOX0lTQk4+MDE3Mi0wNjQzPC9JU1NOX0lTQk4+
PE1pc2NfMz4xMC4xMDA3L3MwMDI0Ni0wMDUtMDk5Mi02PC9NaXNjXzM+PEFkZHJlc3M+RGl2aXNp
b24gb2YgQ2FyZGlvbG9neSwgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBJbmRpYW5hIFVuaXZl
cnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBJbmRpYW5hcG9saXMsIElOIDQ2MjAyLCBVU0EuIGFi
YXRyYUBpdXB1aS5lZHU8L0FkZHJlc3M+PFdlYl9VUkw+UE06MTYzOTE5NzI8L1dlYl9VUkw+PFpa
X0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+UGVkaWF0cmljIGNhcmRpb2xvZ3k8L2Y+PC9a
Wl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPlBlZGlh
dHIuQ2FyZGlvbDwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpf
V29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (260)16391972Retrospective, single center336336 consecutive pts surg for CHD/1 y.JET 8%, 27/336 ptsIdentify risk factors for postop JETHighest risk: TGA arterial switch, 23%; AVSD 21%; Norwood, 20%.JET pts younger, longer CPB times, hgher iinotrope schore, longer ischemic timeJET incidence 8%.Andreasen JB2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZHJlYXNlbjwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFuZHJlYXNlbjwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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=
ADDIN EN.CITE.DATA (261)18196218Retrospective single center, case-control874874 pts <16 y, CHD surgery 1/98-12/05Among JET pts: 26% had VSD closure; more often in pts w/ high RACHS score; 25% had surgery NOT near the AVN.Identify risk factors for postop JETIncidence 10.2%, CPB >90 min (OR: 2.6); high inotropes (OR: 2.6); high postop CK-MB (OR: 3.1). Mortality increased: 13.5% vs. 1.7%; 12 deaths. Prolonged LOS.Rx protocol: sedation/electrolytes; reduced inotropes; reduced core temp to 34-35 d C; muscle relaxation, IV amiodarone.Borgman KY 2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvcmdtYW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvcmdtYW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (262)21740877Retrospective Single center,36CHD pts developing JET postop compared w/ CHD pts w/o JETAssess genetic polymorphism in CHD pts who develop postop JETRisks for JET postop included, age, inotrope score, bypass time, crossclamp time. ACE I/D genotype associated w/ 2-fold increase in risk for JET.ACE I/D polymorphism may be risk factor for JETMakhoul M2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1ha2hvdWw8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1ha2hvdWw8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (263)22987106Single center, retrospective, matched cohorts54Pts <21 y, CHD surgery 1/06-6/10 Emory. Narrow QRS tach >150 bpm.Identified JET in 54, incidence 1.4%out of 2450 pts undergoing CPB.One death in each group, 1.8%.JET risk factors↑risk: weight <4 kg, CPB >100 min; postop lactic acid >20 mg/dL. Rx: ↓ surface cooling core temp 35 d C, ↓exogenous catech; optimize sedation: used in 96%. Atrial overdrive pacing used 74%. Amiodarone 78%, Procainamide 9%; esmolol 6%.Lower mortality and incidence JET than prior studies. Study not designed to assess drug efficacy.Pediatrics: JET Therapy Pfammatter JP1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBmYW1tYXR0ZXI8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBmYW1tYXR0ZXI8L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFy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ADDIN EN.CITE.DATA (264)7677480Retrospective single center6Postop JET treated w/ hypothermia. 6 consecutive pts, surface cooling to rectal temperature 32-34 d C; sedated, vent. Cooling maintained 24-88 h. Assess rx postop JET w/ hypothermiaMean interval Dx JET and start hypothermia 4 h. JET rate ↓from 219 to 165 bpm mean.Early institution moderate hypothermia effective in lowering HRWalsh EP 1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbHNoPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVj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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbHNoPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVj
TnVtPjM4MTwvUmVjTnVtPjxJRFRleHQ+RXZhbHVhdGlvbiBvZiBhIHN0YWdlZCB0cmVhdG1lbnQg
cHJvdG9jb2wgZm9yIHJhcGlkIGF1dG9tYXRpYyBqdW5jdGlvbmFsIHRhY2h5Y2FyZGlhIGFmdGVy
IG9wZXJhdGlvbiBmb3IgY29uZ2VuaXRhbCBoZWFydCBkaXNlYXNlPC9JRFRleHQ+PE1ETCBSZWZf
VHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+MzgxPC9S
ZWZfSUQ+PFRpdGxlX1ByaW1hcnk+RXZhbHVhdGlvbiBvZiBhIHN0YWdlZCB0cmVhdG1lbnQgcHJv
dG9jb2wgZm9yIHJhcGlkIGF1dG9tYXRpYyBqdW5jdGlvbmFsIHRhY2h5Y2FyZGlhIGFmdGVyIG9w
ZXJhdGlvbiBmb3IgY29uZ2VuaXRhbCBoZWFydCBkaXNlYXNlPC9UaXRsZV9QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+V2Fsc2gsRS5QLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
U2F1bCxKLlAuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TaG9sbGVyLEcuRi48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRyaWVkbWFuLEouSy48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkpvbmFzLFIuQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0
aG9yc19QcmltYXJ5Pk1heWVyLEouRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
Pldlc3NlbCxELkwuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk3LzQ8L0RhdGVf
UHJpbWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFtaW9kYXJv
bmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48
S2V5d29yZHM+QXRyaW92ZW50cmljdWxhciBCbG9jazwvS2V5d29yZHM+PEtleXdvcmRzPkJvc3Rv
bjwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXRl
Y2hvbGFtaW5lczwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkPC9LZXl3b3Jkcz48S2V5d29yZHM+
Q2hpbGQsUHJlc2Nob29sPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2xpbmljYWwgUHJvdG9jb2xzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+Y29uZ2VuaXRhbDwvS2V5d29yZHM+PEtleXdvcmRzPkRpZ294aW48
L0tleXdvcmRzPjxLZXl3b3Jkcz5EaXNlYXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+ZXRpb2xvZ3k8
L0tleXdvcmRzPjxLZXl3b3Jkcz5FdmFsdWF0aW9uIFN0dWRpZXMgYXMgVG9waWM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IERlZmVjdHMsQ29uZ2Vu
aXRhbDwvS2V5d29yZHM+PEtleXdvcmRzPkhlbW9keW5hbWljczwvS2V5d29yZHM+PEtleXdvcmRz
Pkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkh5cG90aGVybWlhLEluZHVjZWQ8L0tleXdvcmRz
PjxLZXl3b3Jkcz5JbmNpZGVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5JbmZhbnQ8L0tleXdvcmRz
PjxLZXl3b3Jkcz5JbmZhbnQsTmV3Ym9ybjwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5d29yZHM+PEtleXdvcmRzPlBoZW55dG9pbjwv
S2V5d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlBv
c3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9uczwvS2V5d29yZHM+PEtleXdvcmRzPlByb2NhaW5hbWlk
ZTwvS2V5d29yZHM+PEtleXdvcmRzPlByb3ByYW5vbG9sPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVz
ZWFyY2g8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFj
aHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxFY3RvcGljIEp1bmN0aW9u
YWw8L0tleXdvcmRzPjxLZXl3b3Jkcz50aGVyYXBldXRpYyB1c2U8L0tleXdvcmRzPjxLZXl3b3Jk
cz50aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGltZTwvS2V5d29yZHM+PEtleXdvcmRzPlZl
cmFwYW1pbDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1Bh
Z2U+MTA0NjwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTA1MzwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+
Si5BbS5Db2xsLkNhcmRpb2wuPC9QZXJpb2RpY2FsPjxWb2x1bWU+Mjk8L1ZvbHVtZT48SXNzdWU+
NTwvSXNzdWU+PElTU05fSVNCTj4wNzM1LTEwOTc8L0lTU05fSVNCTj48TWlzY18zPlMwNzM1MTA5
Nzk3MDAwNDA1PC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBDaGls
ZHJlbiZhcG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFz
c2FjaHVzZXR0cyAwMjExNSwgVVNBLiBlcHdhbHNoQGNhcmRpby50Y2guaGFydmFyZC5lZHU8L0Fk
ZHJlc3M+PFdlYl9VUkw+UE06OTEyMDE1ODwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFt
ZT0iU3lzdGVtIj5KLkFtLkNvbGwuQ2FyZGlvbC48L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfV29y
a2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj5=
ADDIN EN.CITE.DATA (265)9120158Prospective, single center71Staged rx for JET 1986-1994. 71 pts, HR >170 bpm. Stages: ↓catecholamines; correct feve; atrial pacing; digoxin; phenytoine or propranolol or verap; procaine or hypothermia; combine procainamide + hypothermiaAssess rx JET postopSuccess: reduce HR <170 w/in 2 h.Treatment success 70/71 pts. JET associated w/ young age, transient AV block, VSD closures Only correction of fever and combined procainamide + hypothermia efficacious. Laird WP 2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhaXJkPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxhaXJkPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (266)12370794Retrospective, single center1111 pediatric postop CHD pts w/ JET, mean HR 203 bpm. IV amiodarone 5 mg/kg x2 given, followed by infusion 10-15 mg/kg/d for 48-72 h. Amiodarone efficacy for postop JETAmiodarone in higher dose (10 mg/kg vs. 5 mg/kg) achieved control more rapids. Hypotension/bradycardia 2 pts. Amiodarone 10 mg/kg IV effective for rapid control of postop JET; continuous infusion necessary.Plumpton K2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Plumpton</Author><Year>2005</Year><RecNum>569</RecNum><IDText>Amiodarone for post-operative junctional ectopic tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>569</Ref_ID><Title_Primary>Amiodarone for post-operative junctional ectopic tachycardia</Title_Primary><Authors_Primary>Plumpton,K.</Authors_Primary><Authors_Primary>Justo,R.</Authors_Primary><Authors_Primary>Haas,N.</Authors_Primary><Date_Primary>2005/2</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>adverse effects</Keywords><Keywords>Amiodarone</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Bradycardia</Keywords><Keywords>Cardiac Surgical Procedures</Keywords><Keywords>diagnosis</Keywords><Keywords>drug therapy</Keywords><Keywords>etiology</Keywords><Keywords>Heart</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Heart Rate</Keywords><Keywords>Heart Septal Defects,Ventricular</Keywords><Keywords>Humans</Keywords><Keywords>Hypotension</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Intensive Care</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Keywords>Tetralogy of Fallot</Keywords><Keywords>therapeutic use</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>13</Start_Page><End_Page>18</End_Page><Periodical>Cardiol.Young</Periodical><Volume>15</Volume><Issue>1</Issue><ISSN_ISBN>1047-9511</ISSN_ISBN><Misc_3>S1047951105000041;10.1017/S1047951105000041</Misc_3><Address>Paediatric Cardiac Intensive Care Unit, The Prince Charles Hospital, Chermside, Brisbane, Queensland, Australia</Address><Web_URL>PM:15831155</Web_URL><ZZ_JournalFull><f name="System">Cardiology in the young</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Cardiol.Young</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(267)15831155Retrospective, single center1515 postop pediatric CHD pts, JET, median 2.6 mo. JET rates 182-229 bpm, median 192 bpm. IV amiodaroneAmiodarone efficacy for postop JETAmiodarone controlled tachycardia, median time 4.5 h, median dose 5.9 mg/kg. Hypotension or bradycardia in 2 pts. Amiodarone controlled post-op JET rapidly. Haas NA 2008 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhYXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNO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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhYXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (268)19026806Prospective observational 7171 of 2106 CPB pts repair CHD received amiodarone for postop atrial (70) or ventricular (7) tachycardia. Median age 3 mo. JET 37, ectopic AT 10, atrial flutter 8, AF 1, IART 1. Early rx: w/in 60 min of arrhythmia detection vs. >60 min. Protocol: reduce inotropes, correct lytes; IV amiodarone. Dose 5 mg/kg over 1-4 h, infusion 5-15 mcg/kg/min. Repeat boluses; infusion 5-10 mg/kg/d. Assess response of postop tachycardia to IV amiodaroneEarly rx postop tachycardia reduced rate (156 vs. 300 bpm, p<0.01); time to control (400 vs. 1038 min, p<0.001), reduced dose (28 vs. 67 mg, p<0.025), and ICU LOS (3.3 vs. 5.3 d, p<0.01). Early RX w/ amiodarone (60 min) significant improved outcomes. Collins KK2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (269)19232902Multicenter retrospective 94Non postoperative JET, median age 0.8 y, range fetus – 16 y). . Time frame 1969-2008. CHF 16%. VA dissociated 56%, 1:1 VA 32%; both 3%, NOS 9%. Median f/u 4.5 y. Assess outcomes of rx for non postop JET in pediatric ptsMedications used in 89%; 62% ≥2 medications.Amiodarone used 60%, alone in 20%, combo w/ beta blocker (15%), procainamide, dif, flecainide, propafenone. Ablation: indication CHF or refractory to medications; elective 15%. RF 17, cryoablation 27, efficacy 82 vs. 85%, p=NS; recurrence 13-14%; inadvertent CHB 18% of RF pts. AV node ablation 3%, pacer 14%. Deaths 4%, all age ≤6 mo. 70% no chronic medical rx for JET. Amiodarone effective in 60%; Ablation: 47%: efficacy 82-85%, recurrence 13-14%, 18% inadvertent CHB in RF pts; 3% underwent intentional ablation AVN.Pacers 14% of ablation pts. Kovacikova L 2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktvdmFjaWtvdmE8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktvdmFjaWtvdmE8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (270)19632422Retrospective single center40Postop CHD ptsIV amiodarone 2 mg/kg boluses, continuous infusion 10=15 mcg/kg/minAssess IV amiodarone as rx for postop JETAmiodarone effective 45%; SR in 7, decreased HR 11; allowed effective atrial pacing w/ AV synchrony. Failure of amiodarone associated w/ higher AV oxygen saturation difference, lower body temp. Amiodarone achieved SR in 45% as first line; recommend in combo w/ hypothermia. Pediatrics: EP Study/RiskKlein GJ1979492252 ADDIN REFMGR.CITE <Refman><Cite><Author>Klein</Author><Year>1979</Year><RecNum>169</RecNum><IDText>Ventricular fibrillation in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>169</Ref_ID><Title_Primary>Ventricular fibrillation in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Klein,G.J.</Authors_Primary><Authors_Primary>Bashore,T.M.</Authors_Primary><Authors_Primary>Sellers,T.D.</Authors_Primary><Authors_Primary>Pritchett,E.L.</Authors_Primary><Authors_Primary>Smith,W.M.</Authors_Primary><Authors_Primary>Gallagher,J.J.</Authors_Primary><Date_Primary>1979/11/15</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Prevalence</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1080</Start_Page><End_Page>1085</End_Page><Periodical>N.Engl.J Med</Periodical><Volume>301</Volume><Issue>20</Issue><ISSN_ISBN>0028-4793</ISSN_ISBN><Misc_3>10.1056/NEJM197911153012003</Misc_3><Web_URL>PM:492252</Web_URL><ZZ_JournalFull><f name="System">The New England journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">N.Engl.J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(137)To assess risk of VF in WPW pts.73WPW + h/o VF vs. preexcitation, WPW pts w/ no h/o VFVFThese pts also had high prevelance of reciprocating tachycardia and AF (14 of 25 vs. 18 of 73 [P=0.004]) and multiple APs (5 of 25 vs. four of 73 [P=0.012]). WPW + h/o AF and tachycardia demonstrate rapid conduction over AP during AF.VF was initial manifestation of WPW in 10% of pts: ages 8,9, 16 y. Timmermans C1995 ADDIN REFMGR.CITE <Refman><Cite><Author>Timmermans</Author><Year>1995</Year><RecNum>384</RecNum><IDText>Aborted sudden death in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>384</Ref_ID><Title_Primary>Aborted sudden death in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>Timmermans,C.</Authors_Primary><Authors_Primary>Smeets,J.L.</Authors_Primary><Authors_Primary>Rodriguez,L.M.</Authors_Primary><Authors_Primary>Vrouchos,G.</Authors_Primary><Authors_Primary>van den Dool,A.</Authors_Primary><Authors_Primary>Wellens,H.J.</Authors_Primary><Date_Primary>1995/9/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiology</Keywords><Keywords>Chi-Square Distribution</Keywords><Keywords>Child,Preschool</Keywords><Keywords>complications</Keywords><Keywords>Death,Sudden,Cardiac</Keywords><Keywords>Electrophysiology</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Heart Septum</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Sex Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Keywords>Ventricular Fibrillation</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>492</Start_Page><End_Page>494</End_Page><Periodical>Am.J.Cardiol.</Periodical><Volume>76</Volume><Issue>7</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002914999801362</Misc_3><Address>Department of Cardiology, Academic Hospital, Maastricht, The Netherlands</Address><Web_URL>PM:7653450</Web_URL><ZZ_JournalFull><f name="System">Am.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(271)7653450Retrospective, single center1515/690 pts w/ WPW referred 1/79-2/95 presented w/ cardiac arrest. 53% not known to have WPW. EP study done to assess AP characteristics. Characterize WPW pts w/ arrestVF initial manifestation in 8 pts. 10/15 exercising. 7 pts known ORT/AF. 9/11 EP study: AP ERP≤250 msec. Multiple AP not a risk. VF 2.2% of series; all under age 45 y, half under age 30y. Ceresnak SR2012 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNlcmVzbmFrPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNlcmVzbmFrPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE.DATA (272) 22324823Retrospective, multi-center 301147 pts w/ WPW underwent EP study; 30 pts (2.6%) w/ ADT. Mean age 16±3 y. Assess EP characteristics of pts w/ ADT7% w/ CHD13% more than one APLeft sided AP 53%; right 47% often septalHigh risk in 17 pts (57%)ADT rare in children w/ WPW undergoing ablation, 2.6%57% w/ ADT had high risk characteristicsBrembilla Perot B2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDEz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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJyZW1iaWxsYS1QZXJyb3Q8L0F1dGhvcj48WWVhcj4yMDEz
PC9ZZWFyPjxSZWNOdW0+MzgyPC9SZWNOdW0+PElEVGV4dD5JbmNpZGVuY2UgYW5kIHByb2dub3N0
aWMgc2lnbmlmaWNhbmNlIG9mIHNwb250YW5lb3VzIGFuZCBpbmR1Y2libGUgYW50aWRyb21pYyB0
YWNoeWNhcmRpYTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3Vy
bmFsPC9SZWZfVHlwZT48UmVmX0lEPjM4MjwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PkluY2lkZW5j
ZSBhbmQgcHJvZ25vc3RpYyBzaWduaWZpY2FuY2Ugb2Ygc3BvbnRhbmVvdXMgYW5kIGluZHVjaWJs
ZSBhbnRpZHJvbWljIHRhY2h5Y2FyZGlhPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
QnJlbWJpbGxhLVBlcnJvdCxCLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+UGF1
cmlhaCxNLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2VsbGFsLEouTS48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlppbnppdXMsUC5ZLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+U2Nod2FydHosSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5PkRlLENoaWxsb3UgQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5
PkNpc21hcnUsRy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkJldXJyaWVyLEQu
PC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Wb2lsbGlvdCxELjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2VsdG9uLE8uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5Mb3VpcyxQLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QW5k
cm9uYWNoZSxNLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Tm9zdSxSLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+ZGUgbGEgQ2hhaXNlLEEuVC48L0F1dGhvcnNf
UHJpbWFyeT48RGF0ZV9QcmltYXJ5PjIwMTMvNjwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZG9s
ZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2Ug
RGlzdHJpYnV0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRz
PkFnZWQsODAgYW5kIG92ZXI8L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmlicmlsbGF0aW9u
PC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlhYyBQYWNpbmcsQXJ0aWZpY2lhbDwvS2V5d29yZHM+
PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+
PEtleXdvcmRzPkNoaWxkLFByZXNjaG9vbDwvS2V5d29yZHM+PEtleXdvcmRzPkNvbW9yYmlkaXR5
PC9LZXl3b3Jkcz48S2V5d29yZHM+ZGlhZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ry
b2NhcmRpb2dyYXBoeTwvS2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9waHlzaW9sb2dpYyBUZWNo
bmlxdWVzLENhcmRpYWM8L0tleXdvcmRzPjxLZXl3b3Jkcz5lcGlkZW1pb2xvZ3k8L0tleXdvcmRz
PjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5GcmFuY2U8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5JbmNpZGVuY2U8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5Jc29wcm90ZXJlbm9sPC9LZXl3b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+
PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29y
ZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJlLUV4Y2l0YXRpb24g
U3luZHJvbWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+UmVwcm9kdWNpYmlsaXR5IG9mIFJlc3VsdHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrIEFz
c2Vzc21lbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5TZW5zaXRpdml0eSBhbmQgU3BlY2lmaWNpdHk8
L0tleXdvcmRzPjxLZXl3b3Jkcz5TZXhpc208L0tleXdvcmRzPjxLZXl3b3Jkcz5zdGF0aXN0aWNz
ICZhbXA7IG51bWVyaWNhbCBkYXRhPC9LZXl3b3Jkcz48S2V5d29yZHM+U3luY29wZTwvS2V5d29y
ZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEs
QXRyaW92ZW50cmljdWxhciBOb2RhbCBSZWVudHJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+WW91bmcg
QWR1bHQ8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdl
Pjg3MTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+ODc2PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5FdXJv
cGFjZTwvUGVyaW9kaWNhbD48Vm9sdW1lPjE1PC9Wb2x1bWU+PElzc3VlPjY8L0lzc3VlPjxJU1NO
X0lTQk4+MTUzMi0yMDkyPC9JU1NOX0lTQk4+PE1pc2NfMz5ldXMzNTQ7MTAuMTA5My9ldXJvcGFj
ZS9ldXMzNTQ8L01pc2NfMz48QWRkcmVzcz5EZXBhcnRtZW50IG9mIGNhcmRpb2xvZ3ksIFVuaXZl
cnNpdHkgSG9zcGl0YWwgb2YgQnJhYm9pcywgNTQ1MDAgVmFuZG9ldXZyZSwgTGVzIE5hbmN5LCBG
cmFuY2UuIGIuYnJlbWJpbGxhLXBlcnJvdEBjaHUtbmFuY3kuZnI8L0FkZHJlc3M+PFdlYl9VUkw+
UE06MjMxNDgxMjA8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+RXVy
b3BhY2UgOiBFdXJvcGVhbiBwYWNpbmcsIGFycmh5dGhtaWFzLCBhbmQgY2FyZGlhYyBlbGVjdHJv
cGh5c2lvbG9neSA6IGpvdXJuYWwgb2YgdGhlIHdvcmtpbmcgZ3JvdXBzIG9uIGNhcmRpYWMgcGFj
aW5nLCBhcnJoeXRobWlhcywgYW5kIGNhcmRpYWMgY2VsbHVsYXIgZWxlY3Ryb3BoeXNpb2xvZ3kg
b2YgdGhlIEV1cm9wZWFuIFNvY2lldHkgb2YgQ2FyZGlvbG9neTwvZj48L1paX0pvdXJuYWxGdWxs
PjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+RXVyb3BhY2U8L2Y+PC9aWl9K
b3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9D
aXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (273)23148120Retrospective, single center63807 pts w/ WPW underwent EP study; ADT induced in 63 pts (8%)Ages Assess EP characteristics of pts w/ WPW and ADTPts w/ ADT more likely to have AF induction (41 vs. 24%, p<.002), and high risk characteristics (22 vs. 12%, p<.02)No difference in age, gender, clinical presentation, ORTClinical outcome did not differ in pts w/ ADT; older pts less likely to have high risk characteristicsPappone C2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBhcHBvbmU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (145)25052405Prospective single center21692169 pts w/ WPW, 8 y prospective study. 1001: no RFA; 1168: RFA. EP study in all. Median f/u 96 mo. 92% f/u. Assess VF or malignant arrhythmias in WPWIn no RFA group, 1.5% experienced VF, vs. 0.4% in no RFA group. VF: 13/15 were children, median age 11 y. Associated w/ short AP ERP (APERP <240 msec) (P <0.001) and AVRT initiating AF, but no sxs. Posteroseptal AP more common among VF pts. VF w/ exertion in 4, at rest in 11. 1.5% VF, almost all in children; risk higher in asymptomatic pts13/15 pts w/ VF <15 y; 2 age 32 y. Pediatrics: AblationKugler JD1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl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 EN.CITE.DATA (167)8164700Retrospective, multi-center 652652 pts underwent 725 ablation procedures between 1/91-9/92,Median age 13.5 y, 84% no SHDAssess outcomes and complications of ablation in young ptsSuccess rates: AVRT and AVNRT 83%; highest in LFW AP and ↑institutional experience; lower in RFW AP, structural heart disease, body weight >80 plications 4.8%, higher in very low weight <15 kg and less institutional experienceUncontrolled, voluntary registryKugler J 1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkt1Z2xlcjwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJl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ADDIN EN.CITE.DATA (274)9399718Retrospective, multi-center 413546 centers, pts 0.1-20.9 y undergoing ablation 1/91-9/15/9688% no SHD58% performed due to family/pt choiceDetermine safety and efficacy of ablation in childhoodSuccess rates: AVRT 90%, higher left >right, 95 vs. 86%; AVNRT 96%; Mean fluoroscopy time 47.6±40 min;Major complications 3.2%Deaths 4 pts, 1 immediate, 3 late (2 infant deaths)Freedom from recurrence at 3 y: AP 77%, AVNRT 71%.Ablation evolving into treatment of choice for SVT in older ptsDeaths in 2 infants noted Higher recurrence than adult pts, but possibly due to higher f/u.Schaffer msec2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjaGFmZmVyPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjaGFmZmVyPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48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ADDIN EN.CITE.DATA (275)10980215Retrospective multicenter10Rviewed 4651 cases in Pediatric RFCA Registry; deaths 0.22%5/4092 w/ normal hearts 0.12%Assess incidence/causes of deathDeaths: all in left sided AP; mural injury, perforation, thromboembolism, vent arrhythmiaWeight 32.7 kg vs. 55.6 kg (p=.023)Number of lesions 26.3 vs. 8.7, (p=.019)Mortality 0.12-0.22% in left sided AP ablations; lower weight, greater number of lesionsBlaufox AD 2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Blaufox</Author><Year>2001</Year><RecNum>386</RecNum><IDText>Radiofrequency catheter ablation in infants </=18 months old: when is it done and how do they fare?: short-term data from the pediatric ablation registry</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>386</Ref_ID><Title_Primary>Radiofrequency catheter ablation in infants </=18 months old: when is it done and how do they fare?: short-term data from the pediatric ablation registry</Title_Primary><Authors_Primary>Blaufox,A.D.</Authors_Primary><Authors_Primary>Felix,G.L.</Authors_Primary><Authors_Primary>Saul,J.P.</Authors_Primary><Date_Primary>2001/12/4</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Body Weight</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>complications</Keywords><Keywords>Disease</Keywords><Keywords>Drug Resistance</Keywords><Keywords>Heart</Keywords><Keywords>Heart Diseases</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Registries</Keywords><Keywords>Safety</Keywords><Keywords>statistics & numerical data</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>2803</Start_Page><End_Page>2808</End_Page><Periodical>Circulation</Periodical><Volume>104</Volume><Issue>23</Issue><ISSN_ISBN>1524-4539</ISSN_ISBN><Address>Childrens' Heart Program of South Carolina, Medical University of South Carolina, Charleston, USA. blaufoad@musc.edu</Address><Web_URL>PM:11733398</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(276) 11733398Retrospective multicenter137Reviewed Pediatric RFCA Registry, 1989-1999, age ≤18 mo, median 0.7 y, weight median 10 kg. 152 procedures, CHD 36%. Outcomes ablation in age ≤18 moSuccess 87.6%, vs. 90.6%, NSMajor comps 4.6% vs. 2.9%, p=.17No difference in success or complications ≤18 moBlaufox AD 2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJsYXVmb3g8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJsYXVmb3g8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (277)14764175Retrospective single center1818 RFA in pts <15 kg 1/88-8/01; median weight 5.7 kg, age 5.8 mo; 4 CHD, 4 CHFOutcomes ablation <15 kgORT 9, MAT 1, VT 4; success all AP; no plications 3/18 myocardial infarct 1 occluding left circ, CHF, mitral valve replacement; torn mitral leaflet 1Complications 16% associated w/ RF dose indexed for body size (duration and number)Mitral valve replacementVan Hare G2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBIYXJlPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBIYXJlPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (278)15250858 Prospective, multi-center481Pts ≤16 y, w/o significant heart disease, w/ AVRT or AVNRT; compared w/ cohort-eligible registry pts, N =504Assess success rates and complications in age <16 yAcute success: 96%, highest in left sided AP; left 98% vs. right 91%Complications 4.2%; no deaths; AV block 1.2% in AVNRT or septal ACHigh success rates for AVNRT or AVRT w/o CHDVan Hare G2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBIYXJlPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbiBIYXJlPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (279)15851152Prospective, multi-center481 481 pts w/ AVRT or AVNRT, excluding pts w/ significant heart diseaseAges 0.1-16 yFollowed at 2,6,12 mo following ablationAssess recurrence following successful ablation Recurrence at 2,6, 12 mo was 7, 9.2, and 10.7%Recurrence highest right septal AP 24.6%, RFW 15.8%, LFW 9.3%, left septal 4.8%; AVNRT 4.8% vs. 12.9% for AP at 12 moRecurrence after initially successful ablation occurs commonly in children, 10.7%Recurrence less common for AVNRT 4.8%, most common for right sided AP >25% at one yAiyagari R 2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFpeWFnYXJpPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFpeWFnYXJpPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (280)16132307Retrospective, single center69All pts ≤20 kg undergoing ablation between 1/94-1/03Group 1, <15 kg, 25 ptsGroup 2, 15.1-20 kg, 44 ptsCompare safety and efficacy of ablation in pts <15 kg vs. 15.1-20 kgSHD more common in pts <15 kg 28% vs. 7%, p<0.01.No difference in mechanism SVT, number lesions, temperature, procedure time, success rates 91% vs. 89%.Major complications 8% in Group 1, 2.3% Group 2, p=0.39. Outcomes similar between groupsComplications 8% in smaller children, although not statistically significantLee PC2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxlZTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051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=
ADDIN EN.CITE.DATA (281)17461876Retrospective, single center228228 pts 5-18 y old undergoing ablation 12/89 to 8/05Mean age 9±7 y; mean f/u 86±38 moAssess results of ablation in pediatric pts 5-18 yAVRT 61%, AVNRT 29%, AT 5%, atrial flutter 5%. Success rates 92% AVRT, 97% AVNRT, 82% AT, 91% atrial flutter. Complications 8.7%, major 0.9% AV block; Recurrence 4.7% AVRT incidence higher than in adults; Success rates lowest for AT 82%; other mechanisms 91-97%. Complications 8.7%, recurrence 4.7%Chiu SN 2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJ1ZGRoZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJ1ZGRoZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE.DATA (282)19609044Retrospective single center2727/210 pts underwent RF at age <6 y. Median age 4.4 y (8 mo-5.9 y). Median weight 15 kg (6.6-30 kg). AVRT 55%, atrial flutter 19%, AVNRT 15%. SHD 33%. Outcomes ablation <6 y. Indications: drug refractory SVT, or tach-induced cardiomyopathy. Acute success 93%, recurrence 7.4%. Acute success 93%, recurrence 7.4%.CHB 3.7% in 5 y old. Schneider HE2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjaG5laWRlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjaG5laWRlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE.DATA (283) 19324303Prospective, single center 212212 pts ages <21 y undergoing ablation for SVT underwent selective coronary angiography before and 30 min after RFA or cryoablation; CHD present in 15%Median age 12 y (0.3-20.4 y)Median weight 47 kg (5.5–130 kg)Assess incidence of coronary injury following ablationAP 53%; AVNRT 40%, both 7%Coronary artery narrowing identified in 2/117 pts (1.7%) w/ AP, both in posteroseptal region. Coronary artery injury present in 1.7% of AP ablations: both in posteroseptal regionConsider coronary angiography w/ ablation in posteroseptal regionKantoch MJ 2011PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbnRvY2g8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbnRvY2g8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (284)21621374Retrospective single center341995-2009, 34 pts <2y of age, RFA 42 procedures in 31 pts, mean wt 7.4 kg; 17/34 CHF; 3 pts ECMOOutcomes ablation <2 yAVRT 19, Focal 6, atrial flutter 1, VT 3, JET 2Acute success 74% vs. 91% >2yNo recurrence mean 7.3 yMajor complications 4/34 children; CHB, pacer in 6 wk old infant; RFA occusion x 2,Major complications 11.8% vs. 0.7% in >2 y of age Buddhe S 2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJ1ZGRoZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJ1ZGRoZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE.DATA (282)22452328Retrospective single center1551/05-12/09, 155 pts ablation for SVT. Mean age 13.4±3.7 y. 22% African American. RF 107, Cryoablation 11, Both 97. AVRT 74%, AVNRT 17%; SNRT 5%, His bundle reentry 4%. . Median f/u 41 mo. Outcomes ablation during longer f/uAcute success 98%; 5 y f/u 83% success. Recurrences higher w/ right anterior-anteroseptal AC (33%), multiple (27%), or broad distribution. Recurrence not statistical different RF (14%) vs. Cryoablation (22%) or both (20%)17% recurrence WPW or SVT during mean f/u 38 mo. Recurrences higher vs. age, 11.7 y vs. 13.6 y (p<0.05).Pediatrics: QOL & Cost EffectivenessGarson A1997 ADDIN REFMGR.CITE <Refman><Cite><Author>Garson</Author><Year>1997</Year><RecNum>396</RecNum><IDText>Management of the child with Wolff-Parkinson-White syndrome and supraventricular tachycardia: model for cost effectiveness</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>396</Ref_ID><Title_Primary>Management of the child with Wolff-Parkinson-White syndrome and supraventricular tachycardia: model for cost effectiveness</Title_Primary><Authors_Primary>Garson,A.,Jr.</Authors_Primary><Authors_Primary>Kanter,R.J.</Authors_Primary><Date_Primary>1997/11</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>analysis</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>Chronic Disease</Keywords><Keywords>Cost-Benefit Analysis</Keywords><Keywords>Disease</Keywords><Keywords>Humans</Keywords><Keywords>Intensive Care</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Recurrence</Keywords><Keywords>Sensitivity and Specificity</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Reprint>Not in File</Reprint><Start_Page>1320</Start_Page><End_Page>1326</End_Page><Periodical>J.Cardiovasc.Electrophysiol.</Periodical><Volume>8</Volume><Issue>11</Issue><ISSN_ISBN>1045-3873</ISSN_ISBN><Address>Baylor College of Medicine, Houston, Texas, USA</Address><Web_URL>PM:9395176</Web_URL><ZZ_JournalFull><f name="System">J.Cardiovasc.Electrophysiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(285)9395176Cost modelingN/ACost-effectiveness modeling for ablation vs. medications or surgery for WPW treatment in pts age 5-21 yIdentify long term cost effectiveness of treatment strategiesAblation cost 39% of surgical rx, and 57% of medical management. Estimated mortality ablation 0.15% = 10% of medical rx, and 28% of surgical rxMorbidity ablation = 32% of medications, and 36% of surgeryCatheter ablation has lower cost, mortality and morbidity than either medical rx or surgery, and is treatment of choice for the child 5 y of age or older w/ WPW and SVT. Pfammatter JP2004 ADDIN REFMGR.CITE <Refman><Cite><Author>Pfammatter</Author><Year>2004</Year><RecNum>397</RecNum><IDText>Impact of curative ablation on pharmacologic management in children with reentrant supraventricular tachycardias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>397</Ref_ID><Title_Primary>Impact of curative ablation on pharmacologic management in children with reentrant supraventricular tachycardias</Title_Primary><Authors_Primary>Pfammatter,J.P.</Authors_Primary><Authors_Primary>Pavlovic,M.</Authors_Primary><Authors_Primary>Bauersfeld,U.</Authors_Primary><Date_Primary>2004/4</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>drug therapy</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>279</Start_Page><End_Page>282</End_Page><Periodical>Int.J.Cardiol.</Periodical><Volume>94</Volume><Issue>2-3</Issue><ISSN_ISBN>0167-5273</ISSN_ISBN><Misc_3>10.1016/j.ijcard.2003.05.023;S0167527303004030</Misc_3><Address>Division of Pediatric Cardiology, University Children's Hospital Berne, CH 3010 Bern, Switzerland. jean.pierre.pfammatter@insel.ch</Address><Web_URL>PM:15093993</Web_URL><ZZ_JournalFull><f name="System">Int.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(286)15093993Retrospective, single center 88Compare drug therapy vs. ablation as first line in 2 time periods: 1989-94, N = 40, and 1995-2000, N = 48. Early time period: medications onlyLater ablation as first line in 16/48 pts. Assess impact of ablation as first line therapy for SVT in pts >5 y of ageOver time, number of SVT episodes (3.7 to 2), duration of meds (15 mo to 4.6 mo, p<0.05) and numbers of cardioversions declined (1.1/pt to 0.2, p<0.05)Use of ablation as first line treatment in pts over age 5 y results in fewer episodes of SVT and cardioversionsStrieper M 2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0cmllcGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0cmllcGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (287)21106019Prospective, single group, pre-test-posttest design27Consecutive pts w/ SVT referred for catheter ablation between 10/04 – 6/06. Pre and 6 mo post ablation. Ages 5-18 y. Assess impact of ablation on QOL scoresPre test lowest scores in social and physical functioning; post test greatest improvement in physical functioning. Significant improvement in all QOL scores following successful elimination of SVTSignificant improvement in all QOL scores following successful elimination of SVTWood KA2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldvb2Q8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldvb2Q8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (288)20109982Prospective, single group, pre-test-posttest design52Consecutive pts w/ SVT referred for catheter ablation ≥13 y, Mean age 41±17 y, range 13-85 yFemale 65%AVNRT 57%, AVRT 31%, AT 12%Comparison of QOL, sxs before and after ablation procedure for SVTAll sxs decreased but not completely eliminated at 1 mo f/uImprovements in palpitations, p=0.001, Fatigue, p=0.001, Dizziness, p<0.01, resp or chest pressure p<0.001QOL improvements in number, severity and impact of sxs, p<0.001All sxs improved after ablation, women reported larger changes in sxs and QOL than menCHD: Incidence of SVTEngelfriet P2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVuZ2VsZnJpZXQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkVuZ2VsZnJpZXQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFy
PjxSZWNOdW0+NDAzPC9SZWNOdW0+PElEVGV4dD5UaGUgc3BlY3RydW0gb2YgYWR1bHQgY29uZ2Vu
aXRhbCBoZWFydCBkaXNlYXNlIGluIEV1cm9wZTogbW9yYmlkaXR5IGFuZCBtb3J0YWxpdHkgaW4g
YSA1IHllYXIgZm9sbG93LXVwIHBlcmlvZC4gVGhlIEV1cm8gSGVhcnQgU3VydmV5IG9uIGFkdWx0
IGNvbmdlbml0YWwgaGVhcnQgZGlzZWFzZTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwi
PjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjQwMzwvUmVmX0lEPjxUaXRsZV9Q
cmltYXJ5PlRoZSBzcGVjdHJ1bSBvZiBhZHVsdCBjb25nZW5pdGFsIGhlYXJ0IGRpc2Vhc2UgaW4g
RXVyb3BlOiBtb3JiaWRpdHkgYW5kIG1vcnRhbGl0eSBpbiBhIDUgeWVhciBmb2xsb3ctdXAgcGVy
aW9kLiBUaGUgRXVybyBIZWFydCBTdXJ2ZXkgb24gYWR1bHQgY29uZ2VuaXRhbCBoZWFydCBkaXNl
YXNlPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RW5nZWxmcmlldCxQLjwvQXV0aG9y
c19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Qm9lcnNtYSxFLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+T2VjaHNsaW4sRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlRpanNzZW4sSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkdhdHpvdWxp
cyxNLkEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5UaGlsZW4sVS48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkthZW1tZXJlcixILjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+TW9vbnMsUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5Pk1laWpib29tLEYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Qb3BlbG92
YSxKLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGFmb3Jlc3QsVi48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkhpcnNjaCxSLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+RGFsaWVudG8sTC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlRoYXVsb3csRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pk11bGRlcixC
LjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwNS8xMTwvRGF0ZV9QcmltYXJ5PjxL
ZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QW1idWxhdG9yeSBDYXJlPC9LZXl3b3Jk
cz48S2V5d29yZHM+Q2FyZGlvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb3Zhc2N1bGFy
IEFnZW50czwvS2V5d29yZHM+PEtleXdvcmRzPmNvbmdlbml0YWw8L0tleXdvcmRzPjxLZXl3b3Jk
cz5EYXRhIENvbGxlY3Rpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5EaXNlYXNlPC9LZXl3b3Jkcz48
S2V5d29yZHM+ZXBpZGVtaW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+RXVyb3BlPC9LZXl3b3Jk
cz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+Rm9sbG93LVVwIFN0dWRpZXM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IERlZmVj
dHMsQ29uZ2VuaXRhbDwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdv
cmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5tb3J0YWxpdHk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5QYXRpZW50IEFjY2VwdGFuY2Ugb2YgSGVhbHRoIENhcmU8L0tleXdvcmRzPjxLZXl3b3Jk
cz5QYXRpZW50czwvS2V5d29yZHM+PEtleXdvcmRzPlByZWduYW5jeTwvS2V5d29yZHM+PEtleXdv
cmRzPlByZWduYW5jeSBDb21wbGljYXRpb25zLENhcmRpb3Zhc2N1bGFyPC9LZXl3b3Jkcz48S2V5
d29yZHM+c3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwvS2V5d29yZHM+PEtleXdvcmRz
PlN1cnZpdmFsIEFuYWx5c2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFwZXV0aWMgdXNlPC9L
ZXl3b3Jkcz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT4yMzI1PC9T
dGFydF9QYWdlPjxFbmRfUGFnZT4yMzMzPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5FdXIuSGVhcnQg
Si48L1BlcmlvZGljYWw+PFZvbHVtZT4yNjwvVm9sdW1lPjxJc3N1ZT4yMTwvSXNzdWU+PElTU05f
SVNCTj4wMTk1LTY2OFg8L0lTU05fSVNCTj48TWlzY18zPmVoaTM5NjsxMC4xMDkzL2V1cmhlYXJ0
ai9laGkzOTY8L01pc2NfMz48QWRkcmVzcz5EZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEFjYWRl
bWljIE1lZGljYWwgQ2VudHJlLCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kczwvQWRkcmVzcz48
V2ViX1VSTD5QTToxNTk5Njk3ODwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lz
dGVtIj5FdXIuSGVhcnQgSi48L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfV29ya2Zvcm1JRD4xPC9a
Wl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN EN.CITE.DATA (289)15996978Retrospective, multicenter4110CONCOR national registry >8600 pts ACHD >17y of age: Pts w/ ACHD of 8 major types seen in 1998, w/ complete f/u to 2003: (ASD, VSD, TGA, TOF, single ventricle, coarctation, Marfan’s, cyanotic heart disease); followed until 12/2003assess endocarditis, arrhythmias, vascular eventsMedian age 27.9 y, (21.7-38.6y), 79% <50 y oldmedian f/u 5.1 y (3.6-5.7 y); SVA occurred in TOF 20%, TGA 26%; ASD 28%, Fontan 45%Young population w/ ACHD, overall 18% developed SVAVerheugt C2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZlcmhldWd0PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZlcmhldWd0PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA (290)18559697Retrospective, multicenter7414CONCOR registry, Netherlands, >8600 pts ACHD >17 y old 1/02-1/08; assess outcomes frequencies Is gender associated w/ outcomes in ACHDMedian age 35 y (17-91); males 50.2%; median f/u 2.7 y; frequencies of arrhythmias 22-44%; females 12% lower risk arrhythmia, NS; females higher risk for pulmonary HTN15% developed SVA during f/u 2.7 yBouchardy 2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvdWNoYXJkeTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvdWNoYXJkeTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE.DATA (291)19822808Retrospective multicenter38,428 Adult registry Canada; ACHD median age 42 y; 1983-2005; 5812 pts ATAssess risk of developing atrial arrhythmias as adultPrevalence 15.1% AT; impact: 20 y risk for 20 y old 7%, 50 y old 38%; adverse event HR 2.5; mortality 1.47; stroke, CHF 2.21 >50% severe CHD developed AT by age 65 y; 2-3↑ death, stroke, CHFTrojnarska O 2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRyb2puYXJza2E8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRyb2puYXJza2E8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (292)19437395Retrospective, multicenter1304National Polish registry, ACHD pts followed 1995-2004; mean age 29.4±10.6 y, mean f/u 3.5±1.8 yAssess outcomes of SVASVA developed in 10.3% of pts; multivariable predictors; presence of HF (HR: 4.66) CHD complexity (HR: 2.31), age (HR: 1.32) gender NS10.3% developed SVAIncreased w/ CHF, complex CHD, increasing ageBernier M2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlcm5pZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJlcm5pZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (293)20691314Retrospective multicenter 71,467Quebec database; ACHD ≥18 y; study period 1/88–12/05; ACHD pts arrhythmia free by age 18 y in 1/1988assess risk of developing AT vs. type CHD11% developed SVA; 30 y risk for 18 y old: 18% for right sided CHD, 11% for left sided herat diseaseACHD pts arrhythmia free by age 18 y: risk greater in pts w/ right-sided disease vs. left-sidedKhairy P2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktoYWlyeTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktoYWlyeTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN EN.CITE.DATA (294)20713900Retrospective, multicenter566AARCC (Alliance for Adult Research in Cong Card); 11 centers; ACHD ages ≥18 y; study period 9/07-10/08Assess arrhythmia prevalence in TOF adultsMean age 36.8±12 y; f/u; Prevalence SVA 20.1%; risk factors reentrant AT: right atrial enlargement (OR: 6.2); HTN (OR: 2.3), number of cardiac surgeries (OR: 1.4); ventricular arrhythmias 14.6%20.1% of TOF w/ SVACuypers JA 2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkN1eXBlcnM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkN1eXBlcnM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (295) 23886606Retrospective single center85135 pts, Netherlands; surgical ASD closure <15 y of age, (mean 7.5± 3.5 y) between 1968-1980; f/u on 131 ptsAssess SVA development late after ASD closureMean f/u 35 y (30-41 y), 16% developed SVA; 12% developed AF16% AT in f/u ASDValente AM 2014 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbGVudGU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+NDA2PC9SZWNOdW0+PElEVGV4dD5Db250ZW1wb3JhcnkgcHJlZGljdG9ycyBvZiBkZWF0
aCBhbmQgc3VzdGFpbmVkIHZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhIGluIHBhdGllbnRzIHdpdGgg
cmVwYWlyZWQgdGV0cmFsb2d5IG9mIEZhbGxvdCBlbnJvbGxlZCBpbiB0aGUgSU5ESUNBVE9SIGNv
aG9ydDwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9S
ZWZfVHlwZT48UmVmX0lEPjQwNjwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PkNvbnRlbXBvcmFyeSBw
cmVkaWN0b3JzIG9mIGRlYXRoIGFuZCBzdXN0YWluZWQgdmVudHJpY3VsYXIgdGFjaHljYXJkaWEg
aW4gcGF0aWVudHMgd2l0aCByZXBhaXJlZCB0ZXRyYWxvZ3kgb2YgRmFsbG90IGVucm9sbGVkIGlu
IHRoZSBJTkRJQ0FUT1IgY29ob3J0PC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VmFs
ZW50ZSxBLk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5HYXV2cmVhdSxLLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QXNzZW56YSxHLkUuPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5CYWJ1LU5hcmF5YW4sUy5WLjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+U2NocmVpZXIsSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PkdhdHpvdWxpcyxNLkEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5H
cm9lbmluayxNLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+SW51enVrYSxSLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+S2lsbmVyLFAuSi48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PktveWFrLFouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5MYW5kemJlcmcsTS5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
TXVsZGVyLEIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Qb3dlbGwsQS5KLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+V2FsZCxSLjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+R2V2YSxULjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+
MjAxNC8yPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5h
bmFseXNpczwvS2V5d29yZHM+PEtleXdvcmRzPkJvc3RvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNh
bmFkYTwvS2V5d29yZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5D
aGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkLFByZXNjaG9vbDwvS2V5d29yZHM+PEtleXdv
cmRzPkNvaG9ydCBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+Y29tcGxpY2F0aW9uczwvS2V5
d29yZHM+PEtleXdvcmRzPmNvbmdlbml0YWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5PC9LZXl3b3Jkcz48S2V5d29y
ZHM+ZXBpZGVtaW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+RXVyb3BlPC9LZXl3b3Jkcz48S2V5
d29yZHM+RXhlcmNpc2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5FeGVyY2lzZSBUZXN0PC9LZXl3b3Jk
cz48S2V5d29yZHM+SGVhcnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5JbmZhbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWduZXRpYyBSZXNvbmFuY2UgSW1h
Z2luZzwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRk
bGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPm1vcnRhbGl0eTwvS2V5d29yZHM+PEtleXdvcmRz
PlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJlZGljdGl2ZSBWYWx1ZSBvZiBUZXN0czwv
S2V5d29yZHM+PEtleXdvcmRzPlByZXNzdXJlPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvZ25vc2lz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UmVnaXN0cmllczwvS2V5d29yZHM+PEtleXdvcmRzPlJlc2Vh
cmNoPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzazwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2sgRmFj
dG9yczwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNo
eWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFZlbnRyaWN1bGFyPC9LZXl3
b3Jkcz48S2V5d29yZHM+VGV0cmFsb2d5IG9mIEZhbGxvdDwvS2V5d29yZHM+PEtleXdvcmRzPlRp
bWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Vbml0ZWQgU3RhdGVzPC9LZXl3b3Jkcz48S2V5d29yZHM+
WW91bmcgQWR1bHQ8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFy
dF9QYWdlPjI0NzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MjUzPC9FbmRfUGFnZT48UGVyaW9kaWNh
bD5IZWFydDwvUGVyaW9kaWNhbD48Vm9sdW1lPjEwMDwvVm9sdW1lPjxJc3N1ZT4zPC9Jc3N1ZT48
VXNlcl9EZWZfNT5QTUMzOTEzMjE2PC9Vc2VyX0RlZl81PjxJU1NOX0lTQk4+MTQ2OC0yMDFYPC9J
U1NOX0lTQk4+PE1pc2NfMz5oZWFydGpubC0yMDEzLTMwNDk1ODsxMC4xMTM2L2hlYXJ0am5sLTIw
MTMtMzA0OTU4PC9NaXNjXzM+PEFkZHJlc3M+RGVwYXJ0bWVudHMgb2YgQ2FyZGlvbG9neSwgQm9z
dG9uIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNz
LCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCAsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cywgVVNBPC9B
ZGRyZXNzPjxXZWJfVVJMPlBNOjI0MTc5MTYzPC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBu
YW1lPSJTeXN0ZW0iPkhlYXJ0IChCcml0aXNoIENhcmRpYWMgU29jaWV0eSk8L2Y+PC9aWl9Kb3Vy
bmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkhlYXJ0PC9mPjwv
WlpfSm91cm5hbFN0ZEFiYnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURM
PjwvQ2l0ZT48L1JlZm1hbj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlZhbGVudGU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (296)24179163Multicenter, prospective 873Repaired TOF Median age 24.4 y, undergoing standard eval ECG, Exercise, MRIAssess TOF primary outcome of VT or deathSVA developed in 11% (7% atrial flutter, 4% AF); total 3.7% death or VT; Risk for VT or sudden death included ↑RV mass (HR: 5.04), ↓LVEF (HR: 3.34) or h/o atrial arrhythmia (HR: 3.65)TOF pts develop SVA in 11%; SVA significant risk factor for VT or sudden death, HR: 3.65CHD: Mechanisms of SVTCollins KK 2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (297)11053709Retrospective, single center88ACHD, 110 AT macro-reentry circuits, median age 23.4 y, repaired CHD: TGA/atrial repair, 17%,; biventricular CHD 27%; Fontan 49%, other 7Sites of successful ablation for ATNon-Fontan: CTI 57-67%, lateral RA wall 22-43%, anterior RA 11%. Fontan pts: isthmus 15%, lateral RA 53%, anterior 25%, septum 7%CTI involved in right AT in ~60% non-Fontan AT; Fontan multiple RA circuits esp lateral RA wallAkar JG 2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFrYXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxSZWNO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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFrYXI8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (218)11499727Retrospective single center16Consecutive repaired ACHD pts, EP study & ablation, mean ages 32±18 y; 24 circuits. Mean f/u 24 mo ASD/VSD 9; TOF 3, UVH 4. ECG: 44% typical atrial flutter; 56% atypical. Frequency of typical atrial flutter vs. IART in CHD19% typical atrial flutter only; 37% IART alone; 44% both atrial flutter/IART;Isthmus dependent 86% IART;92% successful ablation; only failure=Fontan44% both atrial flutter and IART: Surface ECG did not predict mechanism7% recurrence 2 y. Delacretaz E 2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGFjcmV0YXo8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlbGFjcmV0YXo8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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ADDIN EN.CITE.DATA (199) 11345382Retrospective, single center2047 Atrial reentry circuits mapped in 20 pts, repaired CHD, ASD 10, TOF 6; mean age 43 ±15 yAssess sites of reentry circuitsLateral RA wall 40%, CTI 38%; ASD patch 17%. Acute success 80% pts; mean f/u 19 mo, 20% recurrence. ALL RA macro-reentry, largely ASD or TOF pts; Circuits in 3 sites: lateral RA wall ? CTIDe Groot NM 2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA (298)16648056Retrospective single center 4343 consecutive pts repaired ACHD undergoing EP study/ablation for SVT, mean age 37 y, Assess mechanism of SVT and success of ablationsIART 77% including scar-related 43%, CTI 34%; Focal 16%; AF 3%. Ablation success 70% IART, atrial flutter,focal 100%RA macro-reentry: 77%Focal 16%AF 3%Mah DY 2011PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1haDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1haDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051
bT40MTE8L1JlY051bT48SURUZXh0PlRoZSBlbGVjdHJvYW5hdG9taWMgbWVjaGFuaXNtcyBvZiBh
dHJpYWwgdGFjaHljYXJkaWEgaW4gcGF0aWVudHMgd2l0aCB0ZXRyYWxvZ3kgb2YgRmFsbG90IGFu
ZCBkb3VibGUgb3V0bGV0IHJpZ2h0IHZlbnRyaWNsZTwvSURUZXh0PjxNREwgUmVmX1R5cGU9Ikpv
dXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjQxMTwvUmVmX0lEPjxU
aXRsZV9QcmltYXJ5PlRoZSBlbGVjdHJvYW5hdG9taWMgbWVjaGFuaXNtcyBvZiBhdHJpYWwgdGFj
aHljYXJkaWEgaW4gcGF0aWVudHMgd2l0aCB0ZXRyYWxvZ3kgb2YgRmFsbG90IGFuZCBkb3VibGUg
b3V0bGV0IHJpZ2h0IHZlbnRyaWNsZTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pk1h
aCxELlkuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BbGV4YW5kZXIsTS5FLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2VjY2hpbixGLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+V2Fsc2gsRS5QLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+VHJpZWRtYW4sSi5LLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAx
MS85PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPmFibm9ybWFsaXRpZXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5hbmFseXNpczwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlhbCBGaWJyaWxsYXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5Cb3N0b248L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJkaW9sb2d5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5D
aGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkLFByZXNjaG9vbDwvS2V5d29yZHM+PEtleXdv
cmRzPmNvbmdlbml0YWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5EaXNlYXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ3k8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29y
ZHM+PEtleXdvcmRzPkhlYXJ0IFZlbnRyaWNsZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5JbmZhbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3
b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9L
ZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRo
b2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+
UmVzZWFyY2g8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxFY3RvcGljIEF0cmlhbDwvS2V5d29yZHM+PEtl
eXdvcmRzPlRldHJhbG9neSBvZiBGYWxsb3Q8L0tleXdvcmRzPjxLZXl3b3Jkcz5Zb3VuZyBBZHVs
dDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+MTAx
MzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTAxNzwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+Si5DYXJk
aW92YXNjLkVsZWN0cm9waHlzaW9sLjwvUGVyaW9kaWNhbD48Vm9sdW1lPjIyPC9Wb2x1bWU+PElz
c3VlPjk8L0lzc3VlPjxJU1NOX0lTQk4+MTU0MC04MTY3PC9JU1NOX0lTQk4+PE1pc2NfMz4xMC4x
MTExL2ouMTU0MC04MTY3LjIwMTEuMDIwNjIueDwvTWlzY18zPjxBZGRyZXNzPkRlcGFydG1lbnQg
b2YgQ2FyZGlvbG9neSwgQ2hpbGRyZW4mYXBvcztzIEhvc3BpdGFsIEJvc3RvbiwgSGFydmFyZCBN
ZWRpY2FsIFNjaG9vbCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLCBVU0EuIGRvdWdsYXMubWFoQGNh
cmRpby50Y2guaGFydmFyZC5lZHU8L0FkZHJlc3M+PFdlYl9VUkw+UE06MjE1Mzk2MzY8L1dlYl9V
Ukw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+Si5DYXJkaW92YXNjLkVsZWN0cm9w
aHlzaW9sLjwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3Jt
SUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (299)21539636Retrospective, single center 58Repaired TOF or DORV pts, 1/97 to 3/10; 58 pts w/ 127 AT circuits, mean age 35 yAssess atrial reentry circuits in TOFRA reentry 75%; focal/ectopic 13%; AF 12%; CTI 53% of IART; CTI and lateral RA wall = 85% of IART; AT ablation acute success 90%; 34% recurrence w/in 3 y13% focal; AF 12%; IART 75%:Of IART 53% involve isthmus; acute success high, recurrence moderate; target both isthmus and lateral RA wallKoyak Z 2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktveWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktveWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN EN.CITE.DATA (300)23993125Retrospective multicenter92ACHD pts, CONCOR Dutch database; First onset SVT 1/08-1/11 mean age 51±16 y; AF/atrial flutter >80%; septal defects 50%, left sided CHD 21%.Mech of SVT in ACHDMechanism of SVT described as AF 68%, atrial flutter 14%, AVNRT 8%, “AT” 7%, unspecified 3%AF 68%, atrial flutter 14%AVNRT 8%AT ? focal 7%Wasmer K 2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Wasmer</Author><Year>2013</Year><RecNum>412</RecNum><IDText>Isthmus-dependent right atrial flutter as the leading cause of atrial tachycardias after surgical atrial septal defect repair</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>412</Ref_ID><Title_Primary>Isthmus-dependent right atrial flutter as the leading cause of atrial tachycardias after surgical atrial septal defect repair</Title_Primary><Authors_Primary>Wasmer,K.</Authors_Primary><Authors_Primary>Kobe,J.</Authors_Primary><Authors_Primary>Dechering,D.G.</Authors_Primary><Authors_Primary>Bittner,A.</Authors_Primary><Authors_Primary>Monnig,G.</Authors_Primary><Authors_Primary>Milberg,P.</Authors_Primary><Authors_Primary>Baumgartner,H.</Authors_Primary><Authors_Primary>Breithardt,G.</Authors_Primary><Authors_Primary>Eckardt,L.</Authors_Primary><Date_Primary>2013/10/3</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Germany</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>2447</Start_Page><End_Page>2452</End_Page><Periodical>Int.J.Cardiol.</Periodical><Volume>168</Volume><Issue>3</Issue><ISSN_ISBN>1874-1754</ISSN_ISBN><Misc_3>S0167-5273(13)00430-0;10.1016/j.ijcard.2013.03.012</Misc_3><Address>Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Munster, Germany. Electronic address: wasmerk@ukmuenster.de</Address><Web_URL>PM:23540398</Web_URL><ZZ_JournalFull><f name="System">Int.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(301)23540398Retrospective, single center 5454 pts repaired ASD, mean age 47.3 y at study, 11/95-12/01, 2 pts w/ AF, 10 no inducible AT: 42 pts studied; f/u 7.7 yAssess RA reentry circuits in ASDCTI dependent 69%, of which 40% were clockwise; scar related 17%, both 12%; CTI ablation performed in non-inducible/AF; acute success ~90%; 60% arrhythmia free at 7.7 yASD Ablation aimed at CTI highly successful; 11% developed AFCHD: Pharmacological TherapyFish FA 1991 ADDIN REFMGR.CITE <Refman><Cite><Author>Fish</Author><Year>1991</Year><RecNum>438</RecNum><IDText>Proarrhythmia, cardiac arrest and death in young patients receiving encainide and flecainide. The Pediatric Electrophysiology Group</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>438</Ref_ID><Title_Primary>Proarrhythmia, cardiac arrest and death in young patients receiving encainide and flecainide. The Pediatric Electrophysiology Group</Title_Primary><Authors_Primary>Fish,F.A.</Authors_Primary><Authors_Primary>Gillette,P.C.</Authors_Primary><Authors_Primary>Benson,D.W.,Jr.</Authors_Primary><Date_Primary>1991/8</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Anilides</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>chemically induced</Keywords><Keywords>Child</Keywords><Keywords>Death,Sudden</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Encainide</Keywords><Keywords>epidemiology</Keywords><Keywords>Flecainide</Keywords><Keywords>Heart</Keywords><Keywords>Heart Arrest</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>Patients</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Risk Factors</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>356</Start_Page><End_Page>365</End_Page><Periodical>J.Am.Coll.Cardiol.</Periodical><Volume>18</Volume><Issue>2</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Address>Department of Pediatrics, Children's Memorial Hospital, Northwestern University, Chicago, Illinois</Address><Web_URL>PM:1906902</Web_URL><ZZ_JournalFull><f name="System">J.Am.Coll.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(302)1906902Retrospective multi-center 455455/579 rx for SVT (79%);369 pts rx flecainide (81%) . encainide 19%,Mean age of flecainide death or CA: 9.9 y, range 4d-26 yPro-arrhythmia, cardiac arrest or death w/ flecainide/encainide in young ptsOverall death/CA; 25 pts; 18/25 w/ CHD;Flecainide for SVT: efficacy 7.1%, proarrhythmia 7.4%; cardiac arrest 2.3%;12 pts cardiac arrest; 8/12 CHD: 7/8 mild-mod ventricular dysfunction or single vent or systemic RV Flecainide efficacy SVT 70%; pro-arrhythmia 7.4%; Flecainide rx SVT + CHD: 8.3% death or CA. vs. 0.3% w/o CHD.Deaths flecainide + CHD, average 16.1 y 4 flecainide deaths in structurally normal hearts, 3 of 4 normal function. Thorne SA 1999PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRob3JuZTwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRob3JuZTwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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ADDIN EN.CITE.DATA (303) 10402444Retrospective single center92ACHD, mean age 34.9 y, receiving amiodarone for ≥6 mo; case-control group. Mean duration 3 y, mean dose 191 mgReview side effects of chronic oral amio36% developed thyroid dysfunction: 19 hyper, 14 hypothyroid. Sig risk factors: Female gender (OR: 3.0) cyanotic HD (OR: 7.0); Fontan (OR :4.0); dosage >200 mg/d (OR: 4.0)Pts w/ CHD at higher risk for amiodarone adverse effects, especially women, cyanosis, Fontan, or dose >200 mgPass RH 2000 ADDIN REFMGR.CITE <Refman><Cite><Author>Pass</Author><Year>2000</Year><RecNum>546</RecNum><IDText>Continuous intravenous diltiazem infusion for short-term ventricular rate control in children</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>546</Ref_ID><Title_Primary>Continuous intravenous diltiazem infusion for short-term ventricular rate control in children</Title_Primary><Authors_Primary>Pass,R.H.</Authors_Primary><Authors_Primary>Liberman,L.</Authors_Primary><Authors_Primary>Al-Fayaddh,M.</Authors_Primary><Authors_Primary>Flynn,P.</Authors_Primary><Authors_Primary>Hordof,A.J.</Authors_Primary><Date_Primary>2000/9/1</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Calcium</Keywords><Keywords>Calcium Channel Blockers</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>Diltiazem</Keywords><Keywords>drug therapy</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infusions,Intravenous</Keywords><Keywords>New York</Keywords><Keywords>Patients</Keywords><Keywords>Tachycardia</Keywords><Reprint>Not in File</Reprint><Start_Page>559</Start_Page><End_Page>62, A9</End_Page><Periodical>Am.J.Cardiol.</Periodical><Volume>86</Volume><Issue>5</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002-9149(00)01016-X</Misc_3><Address>Division of Pediatric Cardiology, Babies and Children's Hospital of New York, New York Presbyterian Medical Center, 10032-3784, USA. Pediheart@</Address><Web_URL>PM:11009280</Web_URL><ZZ_JournalFull><f name="System">Am.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(304)11009280Retrospective single center10IV diltiazem for AT w/ rapid response. Includes 3 adults w/ AT and repaired CHD, ages 18-21 y. Efficacy diltiazem for AT Diltiazem 0.25 mg/kg over 5 min + infusion 0.11 mg/kg/h. HR median 166 pre-treatment, fell to 23 bpm w/in 10 min. No HTN. Diltiazem effectively decreased ventricular rate w/in 10 min.Hoyer AW 2007 ADDIN REFMGR.CITE <Refman><Cite><Author>Hoyer</Author><Year>2007</Year><RecNum>432</RecNum><IDText>The safety and efficacy of ibutilide in children and in patients with congenital heart disease</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>432</Ref_ID><Title_Primary>The safety and efficacy of ibutilide in children and in patients with congenital heart disease</Title_Primary><Authors_Primary>Hoyer,A.W.</Authors_Primary><Authors_Primary>Balaji,S.</Authors_Primary><Date_Primary>2007/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Bradycardia</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Pacemaker,Artificial</Keywords><Keywords>Patients</Keywords><Keywords>Safety</Keywords><Keywords>Sulfonamides</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapeutic use</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>1003</Start_Page><End_Page>1008</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>30</Volume><Issue>8</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Misc_3>PACE799;10.1111/j.1540-8159.2007.00799.x</Misc_3><Address>Department of Pediatrics, Division of Pediatric Cardiology, Oregon Health & Science University, Portland, OR 97239, USA</Address><Web_URL>PM:17669084</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(305)17669084Retrospective single center1915 w/ CHD, 4 w/ normal hearts.74 episodes of atrial flutter 4 AF. Median age 16 y. Evaluate efficacy of ibutilide71% successful cardioversion;No symptomatic bradycardia. 1 TdP, 1 NSVTW/ careful monitoring, ibutilide can be an effective tool for cardioversion of flutter.Khairy P2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktoYWlyeTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktoYWlyeTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (306)19808416Retrospective multicenter3737 pts w/ intra-atrial baffle repair of TGA, 7 sites, ages 28±7.6 y, w/ AICD: primary prevention 62%, secondary 38%. ICD and outcomes TGAAnnual rates approximately shock: 0.5% primary, 6% secondary. SVT preceded VT in 50%. Lack of beta-blockers use: HR: 16.7; beta-blockers seem protective for SVT initiating VTMiyazaki A2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1peWF6YWtpPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1peWF6YWtpPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA (307)18931451Retrospective single center27 44 ACHD, mean age 23±12 y, f/u 13±12 mo; oral sotalol 2002-2007; 27 pts SVTEfficacy & safety sotalol in ACHDOverall 41% control; for SVT 52% complete control; Not effective for AFAT w/ AF risk factor for rx failure, OR: 18.3One death 34 y old, AT + AFRao SO2009 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhbzwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhbzwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (308)18653253Prospective, non-randomized1919 pts ACHD, mean age 20 y; present in AT, given oral sotalol 2 mg/kg as inpatientsSotalol for conversionFocal AT 21%, IART 79%;84% conversion w/in 98-145 min; 75% of focal and 87% IART. One fatality after 2 d: thromboembolism. High efficacy 84% for oral sotalol in ACHD acute conversion of ATWells R2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbGxzPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbGxzPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (309)19691680Retrospective multicenter20ACHD pts, 4 institutions, 7 y, rx w/ dofetilide, median age 30 y, 19-53 y.11/20 pts Fontan surgeries. AF 4, IART 13, AF + IART 3. Dosage 125-500 mcg bid. Median f/u ~ 12 mo. Dofetilide efficacy AT in ACHDConversion to SR: 85%. Torsades de pointes: 10%, immediate. Recurrent AT: 65%. 55% taking dofetilide at 1 y. Dofetilide effective acute termination of AT (85%) w/ 10% Torsades de pointes. 65% recurrent AT in 12 mo.ie 35% control AT x 1 y. Garnock-Jones KP 2012 ADDIN REFMGR.CITE <Refman><Cite><Author>Garnock-Jones</Author><Year>2012</Year><RecNum>547</RecNum><IDText>Esmolol: a review of its use in the short-term treatment of tachyarrhythmias and the short-term control of tachycardia and hypertension</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>547</Ref_ID><Title_Primary>Esmolol: a review of its use in the short-term treatment of tachyarrhythmias and the short-term control of tachycardia and hypertension</Title_Primary><Authors_Primary>Garnock-Jones,K.P.</Authors_Primary><Date_Primary>2012/1/1</Date_Primary><Keywords>Adrenergic beta-1 Receptor Antagonists</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Disease</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Heart</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Hypertension</Keywords><Keywords>Hypotension</Keywords><Keywords>Morbidity</Keywords><Keywords>Myocardial Infarction</Keywords><Keywords>Patients</Keywords><Keywords>pharmacokinetics</Keywords><Keywords>pharmacology</Keywords><Keywords>Propanolamines</Keywords><Keywords>Randomized Controlled Trials as Topic</Keywords><Keywords>Risk</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time Factors</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>109</Start_Page><End_Page>132</End_Page><Periodical>Drugs.</Periodical><Volume>72</Volume><Issue>1</Issue><ISSN_ISBN>0012-6667</ISSN_ISBN><Misc_3>8;10.2165/11208210-000000000-00000</Misc_3><Address>Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz</Address><Web_URL>PM:22191799</Web_URL><ZZ_JournalFull><f name="System">Drugs</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Drugs.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(310)22191799Meta-analysis of databasesMEDLINE, EMBASE, and AdisBases databases searched for esmolol and tachycardia, and heart surgery, through 11/2011. Review of databases using esmololIncludes comparison trials w/ other meds: placebo, propranolol, diltiazem, ibutilide, for treatment of SVT and for prophylaxis during heart surgeryHypotension in 2-40% of SVT pts. Resulted in discontinuation in 3-23%Koyak Z 2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktveWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktveWFrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN EN.CITE.DATA (300)23993125Retrospective multicenter92ACHD pts, CONCOR databse; First onset SVT 1/08-1/11 mean age 51±16 y; AF/atrial flutter >80%; septal defects 50%, left sided CHD 21%.Sotalol used in 34%, (mean dose 156 mg) ) and amiodarone 15%,( mean dose 350 mg)Long term efficacy of AA meds90% achieved sinus rhythm. 84% rx w/ chronic oral agents; f/u 2.5±1.4 y; 45% free from SVT. Sotalol or Amiodarone: significantly fewer recurrences, (HR: 0.5); 22% adverse events; all amiodarone pts w/ side effects, thyroid 80%, AVB 20%. Class III agents sotalol and amiodarone more efficacious in maintaining SR; sotalol considered as first choice medRelatively high dose amiodarone associated w/ significant adverse eventsBanchs JE2014 ADDIN REFMGR.CITE <Refman><Cite><Author>Banchs</Author><Year>2014</Year><RecNum>440</RecNum><IDText>Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>440</Ref_ID><Title_Primary>Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease</Title_Primary><Authors_Primary>Banchs,J.E.</Authors_Primary><Authors_Primary>Baquero,G.A.</Authors_Primary><Authors_Primary>Nickolaus,M.J.</Authors_Primary><Authors_Primary>Wolbrette,D.L.</Authors_Primary><Authors_Primary>Kelleman,J.J.</Authors_Primary><Authors_Primary>Samii,S.</Authors_Primary><Authors_Primary>Grando-Ting,J.</Authors_Primary><Authors_Primary>Penny-Peterson,E.</Authors_Primary><Authors_Primary>Davidson,W.R.,Jr.</Authors_Primary><Authors_Primary>Young,S.K.</Authors_Primary><Authors_Primary>Naccarelli,G.V.</Authors_Primary><Authors_Primary>Gonzalez,M.D.</Authors_Primary><Date_Primary>2014/5</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>Heart</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Potassium</Keywords><Keywords>Recurrence</Keywords><Keywords>Safety</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>221</Start_Page><End_Page>227</End_Page><Periodical>Congenit.Heart Dis.</Periodical><Volume>9</Volume><Issue>3</Issue><ISSN_ISBN>1747-0803</ISSN_ISBN><Misc_3>10.1111/chd.12129</Misc_3><Address>Penn State Hershey Heart & Vascular Institute, Penn State University, Hershey, Pa, USA</Address><Web_URL>PM:23947935</Web_URL><ZZ_JournalFull><f name="System">Congenit.Heart Dis.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(311)23947935Prospective non randomized13ACHD, 4 TOF, 1 pulmonary atresia, 2 ASD, 1 dextro-TGA ; 2 L-TGA, 2 tricuspid atresia, 1 asd and vsd, 1 vsd pulmonary atresia, 1 noncompaction; mean age 40±11; median f/u 16 moDofetilide efficacy and safety for AT in ACHD Mechanism of SVT described as AF, atrial flutter or AT70% conversion15% control of recurrencesAverage time to recurrence 5.5 mo39% ddischarge medication due to recurrenceDofetilide well tolerated, Effective for conversion in 70%Recurrence still frequent.Stan MN2014 ADDIN REFMGR.CITE <Refman><Cite><Author>Stan</Author><Year>2012</Year><RecNum>482</RecNum><IDText>A risk prediction index for amiodarone-induced thyrotoxicosis in adults with congenital heart disease</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>482</Ref_ID><Title_Primary>A risk prediction index for amiodarone-induced thyrotoxicosis in adults with congenital heart disease</Title_Primary><Authors_Primary>Stan,M.N.</Authors_Primary><Authors_Primary>Hess,E.P.</Authors_Primary><Authors_Primary>Bahn,R.S.</Authors_Primary><Authors_Primary>Warnes,C.A.</Authors_Primary><Authors_Primary>Ammash,N.M.</Authors_Primary><Authors_Primary>Brennan,M.D.</Authors_Primary><Authors_Primary>Thapa,P.</Authors_Primary><Authors_Primary>Montori,V.M.</Authors_Primary><Date_Primary>2012</Date_Primary><Keywords>Adult</Keywords><Keywords>Amiodarone</Keywords><Keywords>analysis</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>Heart</Keywords><Keywords>Medicine</Keywords><Keywords>Multivariate Analysis</Keywords><Keywords>Patients</Keywords><Keywords>Risk</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>210529</Start_Page><Periodical>J Thyroid Res.</Periodical><Volume>2012</Volume><User_Def_5>PMC3306911</User_Def_5><ISSN_ISBN>2042-0072</ISSN_ISBN><Misc_3>10.1155/2012/210529</Misc_3><Address>Department of Internal Medicine, Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA</Address><Web_URL>PM:22518347</Web_URL><ZZ_JournalFull><f name="System">Journal of thyroid research</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Thyroid Res.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(312)22518347Retrospective single center23ACHD pts developing amiodarone-induced thyrotoxicosis after ≥3 mo amiodarone, Mayo Clinic 1987-2009; median f/u 3.1 y. Identify incidence and risk factors amiodarone thyrotoxicosis13.6% (23/169) ACHD pts developed amiodarone thryrotoxicosis.Highest Risk: low BMI <21, cyanotic heart diseaseCHD: Atrial PacingOlshansky B 1988 ADDIN REFMGR.CITE <Refman><Cite><Author>Olshansky</Author><Year>1988</Year><RecNum>426</RecNum><IDText>Use of procainamide with rapid atrial pacing for successful conversion of atrial flutter to sinus rhythm</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>426</Ref_ID><Title_Primary>Use of procainamide with rapid atrial pacing for successful conversion of atrial flutter to sinus rhythm</Title_Primary><Authors_Primary>Olshansky,B.</Authors_Primary><Authors_Primary>Okumura,K.</Authors_Primary><Authors_Primary>Hess,P.G.</Authors_Primary><Authors_Primary>Henthorn,R.W.</Authors_Primary><Authors_Primary>Waldo,A.L.</Authors_Primary><Date_Primary>1988/2</Date_Primary><Keywords>administration & dosage</Keywords><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Combined Modality Therapy</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Infusions,Intravenous</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Procainamide</Keywords><Keywords>Prospective Studies</Keywords><Keywords>Research</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>359</Start_Page><End_Page>364</End_Page><Periodical>J.Am.Coll.Cardiol.</Periodical><Volume>11</Volume><Issue>2</Issue><ISSN_ISBN>0735-1097</ISSN_ISBN><Misc_3>0735-1097(88)90102-7</Misc_3><Address>Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106</Address><Web_URL>PM:3339174</Web_URL><ZZ_JournalFull><f name="System">J.Am.Coll.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(313)3339174Retrospective single center12Rapid atrial pacing ≥15 sec at ≥10 msec shorter than AT, 12 adult pts, mean 55 y, 2/12 ACHD: VSD, VSD +ASD; mean atrial CL 233 msecConversion rates of AT/atrial flutter w/ rapid atrial pacing2/12 converted w/ rapid atrial pacing10 pts received procaine then repeat rapid atrial pacing: successful in 10 ptsProcaine needed to assist RAP conversion in pts w/ ACHDSilka MJ1990 ADDIN REFMGR.CITE <Refman><Cite><Author>Silka</Author><Year>1990</Year><RecNum>544</RecNum><IDText>Bradycardia-mediated tachyarrhythmias in congenital heart disease and responses to chronic pacing at physiologic rates</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>544</Ref_ID><Title_Primary>Bradycardia-mediated tachyarrhythmias in congenital heart disease and responses to chronic pacing at physiologic rates</Title_Primary><Authors_Primary>Silka,M.J.</Authors_Primary><Authors_Primary>Manwill,J.R.</Authors_Primary><Authors_Primary>Kron,J.</Authors_Primary><Authors_Primary>McAnulty,J.H.</Authors_Primary><Date_Primary>1990/2/15</Date_Primary><Keywords>Aged</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Bradycardia</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Heart</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Pacemaker,Artificial</Keywords><Keywords>Patients</Keywords><Keywords>Pediatrics</Keywords><Keywords>prevention & control</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>488</Start_Page><End_Page>493</End_Page><Periodical>Am.J.Cardiol.</Periodical><Volume>65</Volume><Issue>7</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(90)90816-J</Misc_3><Address>Department of Pediatrics, Oregon Health Sciences University, Portland 97201</Address><Web_URL>PM:2305688</Web_URL><ZZ_JournalFull><f name="System">Am.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(314)2305688Retrospective single center2121 pts, CHD, AT or VT and anti-bradycardia pacing. Mean age 11 y (2-19 y)Assess impact of anti-brady pacing on frequency of AT14 pts w/ AT. Prevention of bradycardia by pacing: significant decrease in SVT (p=0.008) and VTSVT reduced, but not atrial flutterRagonese P1997PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhZ29uZXNlPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJhZ29uZXNlPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48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 EN.CITE.DATA (315)9455751Retrospective single center1818 ACHD pts, recurrent late IART, implanted atrial pacemakers programmed for atrial pacing >80% of time. Atrial anti-brady pacing effect on IART recurrenceRecurrent AT in 29% in first 6 mo. Late recurrences in 11%; 83% arrhythmia free, 2 pts on AA meds.Chronic atrial pacing reduced IART recurrences to 11%. One late sudden death. Brockmeier K2002 ADDIN REFMGR.CITE <Refman><Cite><Author>Brockmeier</Author><Year>2002</Year><RecNum>430</RecNum><IDText>Termination of atrial reentrant tachycardias by using transesophageal atrial pacing</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>430</Ref_ID><Title_Primary>Termination of atrial reentrant tachycardias by using transesophageal atrial pacing</Title_Primary><Authors_Primary>Brockmeier,K.</Authors_Primary><Authors_Primary>Ulmer,H.E.</Authors_Primary><Authors_Primary>Hessling,G.</Authors_Primary><Date_Primary>2002</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Algorithms</Keywords><Keywords>Amiodarone</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Cardiology</Keywords><Keywords>Child</Keywords><Keywords>Child,Preschool</Keywords><Keywords>congenital</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Esophagus</Keywords><Keywords>Germany</Keywords><Keywords>Heart</Keywords><Keywords>Heart Atria</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>159</Start_Page><End_Page>163</End_Page><Periodical>J Electrocardiol.</Periodical><Volume>35 Suppl</Volume><ISSN_ISBN>0022-0736</ISSN_ISBN><Misc_3>10.1054/jelc.2002.37174;S0022073602000614</Misc_3><Address>Department of Pediatric Cardiology, University of Heidelberg, Heidelberg, Germany. konrad_brockmeier@med.uni-heidelberg.de</Address><Web_URL>PM:12539114</Web_URL><ZZ_JournalFull><f name="System">Journal of electrocardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Electrocardiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(316)12539114Retrospective single center3962 conversions in 39 pts, 31 postop CHD, median age 12.5 y (0.1-33 y); “typical atrial flutter 21”, median CL 235 msec TEP conversion of AT in CHD81% successful conversions w/ TEP; 19% underwent CDDVUsed AEST 4-6 x (CL-20) to minimum 120 msec; mA 24-28 TEP converted 81% atrial flutter or ARTStephenson EA2003PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZXBoZW5zb248L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZXBoZW5zb248L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy
PjxSZWNOdW0+NDMxPC9SZWNOdW0+PElEVGV4dD5FZmZpY2FjeSBvZiBhdHJpYWwgYW50aXRhY2h5
Y2FyZGlhIHBhY2luZyB1c2luZyB0aGUgTWVkdHJvbmljIEFUNTAwIHBhY2VtYWtlciBpbiBwYXRp
ZW50cyB3aXRoIGNvbmdlbml0YWwgaGVhcnQgZGlzZWFzZTwvSURUZXh0PjxNREwgUmVmX1R5cGU9
IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjQzMTwvUmVmX0lE
PjxUaXRsZV9QcmltYXJ5PkVmZmljYWN5IG9mIGF0cmlhbCBhbnRpdGFjaHljYXJkaWEgcGFjaW5n
IHVzaW5nIHRoZSBNZWR0cm9uaWMgQVQ1MDAgcGFjZW1ha2VyIGluIHBhdGllbnRzIHdpdGggY29u
Z2VuaXRhbCBoZWFydCBkaXNlYXNlPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U3Rl
cGhlbnNvbixFLkEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DYXNhdmFudCxE
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VHV6aSxKLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+QWxleGFuZGVyLE0uRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0
aG9yc19QcmltYXJ5PkxhdyxJLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2Vy
d2VyLEcuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TdHJpZXBlcixNLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+V2Fsc2gsRS5QLjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+QmVydWwsQy5JLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1h
cnk+MjAwMy8xMC8xPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRz
PjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3
b3Jkcz5BbGdvcml0aG1zPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZpYnJpbGxhdGlvbjwv
S2V5d29yZHM+PEtleXdvcmRzPkF0cmlhbCBGbHV0dGVyPC9LZXl3b3Jkcz48S2V5d29yZHM+Qm9z
dG9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FyZGlhYyBQYWNpbmcsQXJ0aWZpY2lhbDwvS2V5d29y
ZHM+PEtleXdvcmRzPkNhcmRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29y
ZHM+PEtleXdvcmRzPmNsYXNzaWZpY2F0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Y29tcGxpY2F0
aW9uczwvS2V5d29yZHM+PEtleXdvcmRzPmNvbmdlbml0YWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5E
aXNlYXNlPC9LZXl3b3Jkcz48S2V5d29yZHM+ZXRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5G
ZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb2xsb3ctVXAgU3R1ZGllczwvS2V5d29yZHM+PEtl
eXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgRGVmZWN0cyxDb25nZW5pdGFs
PC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5
d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwv
S2V5d29yZHM+PEtleXdvcmRzPlBhY2VtYWtlcixBcnRpZmljaWFsPC9LZXl3b3Jkcz48S2V5d29y
ZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29y
ZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxBdHJpb3ZlbnRy
aWN1bGFyIE5vZGFsIFJlZW50cnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxTdXBy
YXZlbnRyaWN1bGFyPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdv
cmRzPlRpbWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+
PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+ODcxPC9TdGFydF9QYWdl
PjxFbmRfUGFnZT44NzY8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFtLkouQ2FyZGlvbC48L1Blcmlv
ZGljYWw+PFZvbHVtZT45MjwvVm9sdW1lPjxJc3N1ZT43PC9Jc3N1ZT48SVNTTl9JU0JOPjAwMDIt
OTE0OTwvSVNTTl9JU0JOPjxNaXNjXzM+UzAwMDI5MTQ5MDMwMDkwNTY8L01pc2NfMz48QWRkcmVz
cz5EZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgSGFy
dmFyZCBNZWRpY2FsIFNjaG9vbCwgQm9zdG9uLCBNYXNzYWNodXNldHRzIDAyMTE1LCBVU0E8L0Fk
ZHJlc3M+PFdlYl9VUkw+UE06MTQ1MTY4OTg8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5h
bWU9IlN5c3RlbSI+QW0uSi5DYXJkaW9sLjwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Xb3JrZm9y
bUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (317)14516898Retrospective multicenter28ATP in 28 ACHD pts, age 30 ±18 y.Medtronic AT500 pacer. ≥2 episodes AT in 12 mo. Mean f/u 10 mo.ATP detection and termination of AT57% of pts had AT after implant, mean 54 episodes.ATP efficacy for termination: 54%. CHD: DC CardioversionAmmash NM 2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFtbWFzaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFtbWFzaDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE.DATA (318)20934227Retrospective single center6363 ACHD underwent 80 DCCV 6/00-7/03. Flutter most common 46%. f/u 387 dOutcome of DCCVDCCV successful in 94%.60% ACHD pts recurred during f/uall cause mortality was 11% during one y f/u.DCCV safe and effective in ACHD. Recurrence rate is 60%/1 y; AF predicted recurrence, and spontaneous echocardiography contrast in LACHD: Catheter Ablation - NOSTriedman JK1995 ADDIN REFMGR.CITE <Refman><Cite><Author>Triedman</Author><Year>1995</Year><RecNum>488</RecNum><IDText>Radiofrequency ablation of intra-atrial reentrant tachycardia after surgical palliation of congenital heart disease</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>488</Ref_ID><Title_Primary>Radiofrequency ablation of intra-atrial reentrant tachycardia after surgical palliation of congenital heart disease</Title_Primary><Authors_Primary>Triedman,J.K.</Authors_Primary><Authors_Primary>Saul,J.P.</Authors_Primary><Authors_Primary>Weindling,S.N.</Authors_Primary><Authors_Primary>Walsh,E.P.</Authors_Primary><Date_Primary>1995/2/1</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Boston</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Child</Keywords><Keywords>complications</Keywords><Keywords>congenital</Keywords><Keywords>Disease</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Defects,Congenital</Keywords><Keywords>Humans</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Reprint>Not in File</Reprint><Start_Page>707</Start_Page><End_Page>714</End_Page><Periodical>Circulation</Periodical><Volume>91</Volume><Issue>3</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Cardiology, Children's Hospital, Boston, Mass 02115</Address><Web_URL>PM:7828297</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(319)7828297Retrospective single center1010 consecutive ACHD pts, median age 18.4 y (12-43 y). Fontan 6, TGA atrial 2, 2 biVS. 30 IART circuits. Ablate 22 circuits. Median f/u 4 mo. ACHD ablation outcomesCircuits in 4 areas of RA.77% acute success (circuits)50% recurrence short term77% acute success, 50% recurrence short term 4 moKalman JM1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbG1hbjwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl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 EN.CITE.DATA (212)8565168Retrospective single center1818 consecutive ACHD pts, 26 IART circuits, mean age 26 ±15 y map & Ablation 1992-1995. ASD 50%, Fontan 22%, TGA atrial switch 22%, Rastelli 5%; conventional mapping, f/u mean 17 mo. ACHD ablation outcomesAcute success 83%Fontan 50% successAcute success 83%, 50% asymptomatic, no medications during f/u.33% recurrence, plus 7% AFTanner H2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRhbm5lcjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRhbm5lcjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (320)15851168Multicenter retrospective 3636 consecutive ACHD pts, median age 46 y. ASD 20, TOF 8, TGA 5, VSD 1, UVH 1, cc-TGA 1. Mean f/u 17 moACHD ablation outcomes 52 IART circuits; 48 ablations. 65% CTI dependent. 27% incisional, 8% LA. Acute success: 87%. 87% acute success ablation ACHD (2 ventricles predominantly)25% on chronic AA meds92% free of recurrence14% developed AFLukac P2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkx1a2FjPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48UmVj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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkx1a2FjPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48UmVj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=
ADDIN EN.CITE.DATA (321)15851267Retrospective single center5252/83 pts postop ACHD, median age 36 yASD 21, TOF 11, TGA 9; UVH 4, VSD 2Median f/u 27 moACHD ablation outcomesCTI dependent 71%Fontan pts multiple circuits;lateral RA wallCTI dependent 71%-most common, except in Fontan pts31% chronic AA meds24% recurrence13% died or OHTDe Groot NM 2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (322)20194797Retrospective single center53Ablation in 53 ACHD pts, age 38±15 y. Examine characteristics of recurrences after ablation ACHDAtrial flutter 51%; IART 42%; Focal 9%. Acute success 65%; recurrence 59% w/in one y. Repeat ablation 15: 7 similar mechanism.f/u: 5± 3 y: death 9%; AA meds 57%; 31% recurrent AT ACHD: High recurrence 59%; 57% meds; 9% deathRecurrent AT may be different mechanism. Yap SC2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPllhcDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPllhcDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051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==
ADDIN EN.CITE.DATA (323) 21029876Retrospective single center130193 ablations performed in ACHD 130 pts, mean age 40 ±13 y; median f/u 3.4 y. Type of CHD ASD 21%, TGA 18%; UVH 20%; TGA 18%, other 12%Acute & long term outcomes ablation of IART in ACHDAcute success 69%; 5% major comps; pacers 3%; 62% discharged on AA meds;IART recurrence: 4 y =51%; repeat ablation 35%; death 4%. Older age and Fontan palliation predictors of recurrence. Differential outcomes of ablation based on type of CHD: in Fontan pts, 4 y r freedom from recurrence 15% vs.~42% in ASD, TOF, MustardUeda A2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlVlZGE8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlVlZGE8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (324) 23685536Retrospective single center116Ablation 116 ACHD pts, mean age 41 y; 154 procedures, 228 circuits using remote navigation, 3D mapping. F/u mean 20 mo, Group A: manual mappping/ablation; B: remote navigation; C: remote navigation +difficult access. Assess outcomes ablation ACHDCompare simple vs. complex lesions or complex vascular access. AVNRT 5-13%; AVRT 4-7%; Focal 11-26%; atrial flutter 11-39%; IART 23-45%; AF 6-18%. No difference acute success 82-91%, recurrence 20-24%.ACHD population: ablationAcute success >80%; 20-25% recurrence w/in 20 moCHD: Catheter Ablation – ASDTeh AW 2011 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlaDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlaDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (325)21208243Retrospective single center20Ablation AT after ASD repair; mean age 53±13 y; post ASD closure interval 29±15 y. ASD Outcome atrial flutter ablation in All CTI dependent atrial flutter; + other circuits.Acute success 100%; 25% repeat abl at 13 mo. F/u 3.2±1.6 y, 30% documented AF; stroke 5%; 35% AF interventionExcellent acute ablation success ASD: 100%; 25% recur-repeat ablation, 30% AF in 3 y of f/uWasmer K 2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Wasmer</Author><Year>2013</Year><RecNum>412</RecNum><IDText>Isthmus-dependent right atrial flutter as the leading cause of atrial tachycardias after surgical atrial septal defect repair</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>412</Ref_ID><Title_Primary>Isthmus-dependent right atrial flutter as the leading cause of atrial tachycardias after surgical atrial septal defect repair</Title_Primary><Authors_Primary>Wasmer,K.</Authors_Primary><Authors_Primary>Kobe,J.</Authors_Primary><Authors_Primary>Dechering,D.G.</Authors_Primary><Authors_Primary>Bittner,A.</Authors_Primary><Authors_Primary>Monnig,G.</Authors_Primary><Authors_Primary>Milberg,P.</Authors_Primary><Authors_Primary>Baumgartner,H.</Authors_Primary><Authors_Primary>Breithardt,G.</Authors_Primary><Authors_Primary>Eckardt,L.</Authors_Primary><Date_Primary>2013/10/3</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Germany</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Time</Keywords><Reprint>Not in File</Reprint><Start_Page>2447</Start_Page><End_Page>2452</End_Page><Periodical>Int.J.Cardiol.</Periodical><Volume>168</Volume><Issue>3</Issue><ISSN_ISBN>1874-1754</ISSN_ISBN><Misc_3>S0167-5273(13)00430-0;10.1016/j.ijcard.2013.03.012</Misc_3><Address>Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Munster, Germany. Electronic address: wasmerk@ukmuenster.de</Address><Web_URL>PM:23540398</Web_URL><ZZ_JournalFull><f name="System">Int.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(301)23540398Retrospective single center54Consecutive Repaired ASD pts underwent EP study & ablation, mean age 47 y. Mean 22 y postop.f/u in 83%, 7.7 y. Mean AT CL 270 msec. ASD ablation & mechanisms of ATAT at EP study in 78%: RA macroreentry in 100%; CTI dependent 69%; typical atrial flutter 41%. 10% not inducible. CTI ablation in AF or non-inducible. Ablation acute success: 93%93% acute success ablation ASD. 4% recurred w/ different mechanism.60% arrhythmia free during f/u11% developed AFScaglione M2014 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjYWdsaW9uZTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNjYWdsaW9uZTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (326)24843050Retrospective single center4646 repaired ASD pts, mean age 49 y; 89% secundum ASD. ECG atrial flutter 48%, atypical atrial flutter 35%, AT 17%. 41% also AF. Onset AT 19±12 y postop. Complete f/u, 7.3 yASD mechanisms & ablation outcomesTypical AF: 48%, atypical 35%, AT 17%. CTI dependent 26%, 74% atriotomy dependent; Ablation acute success 100%; recur 24%Recur same mechanism w/ gaps. 70% atypical atrial flutter had ECG concordance. ALL RA macro-reentry; no focal.High success ablation for ASD:100%, 24% recurrence20% repeat ablationsCHD: Catheter Ablation – Ebstein’sCappato R 1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhcHBhdG88L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhcHBhdG88L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (327)8759079Retrospective single center21Ebstein pts w/ AVRT: EP study + attempted RFA. 34 right sided AP in 21 pts. Mean age 28±14 y. Mean f/u 22 mo. Ebstein’s ablation outcomes76% acute success ablation AP. 24% recurrent SVT (5 pts, including 4/5 w/ acute success)—4/16 successful ablations-rec SVT=Cath ablation success 76%; 25% recurrence in 22 mo in pts w/ acutely successful ablation.Reich JD 1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJlaWNoPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJlaWNoPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (328)9869537Retrospective multi-center6565 Ebstein’s pts, age 9.8±5.4 y, 82 accessory connections: 62% right, 34% septal, 4% left; only 52% w/ single AP; 9% AP plus atrial tachycardia; 9% non-AP tachycardia.Ebstein’s ablation outcomes Acute success 75-89%. Mild tricuspid regurgitation and BSA <1.7 predicted acute success. SVT related to AC 82%; 18% other atrial tachycardia mechanisms.CHD: Catheter Ablation – UVHDe Groot NM 2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEdyb290PC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN EN.CITE.DATA (329)19808474Retrospective single center1919 Pts w/ UVH, age 29±9 y; 41 SVT circuits; Procedural outcomes of ablation in UVHMechanisms: IART 73%; Typical atrial flutter 10%; Focal 15%; AF 2%. Acute ablation success: 73% IART; 75% atrial flutter; 100% focal f/u 53±34 mo: 16% died; 11% transplantUVH pts: Acute success ~78%Death or OHT : 27%Recurrence: 27% by 53 moYap SC2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPllhcDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPllhcDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (330)22035149Retrospective single center11Ablation in Fontan pts vs. 30 other ACHD pts; atriopulmonary and AV Fontan, mean age 33±0 y. Assess AT substrate after Fontan surgeryFontan pts larger RA (p<.001), larger low-voltage area (p=.01). Acute success Fontan 54% vs. 83% other CHD (p=.04). F/u 2.3±1.6 y, IART recurrence 47%. Fontan pts lower acute success vs. other ACHD high recurrence 47% at 2.3 y all pts; Fontan 50 ±19%, vs. 32 ±10% non-Fontan pts at 2 yLarger RA size and low voltage areas predicted IART recurrenceCorrea R2015PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvcnJlYTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvcnJlYTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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 EN.CITE.DATA (331)25583982Retrospective single center3252 consectutive pts underwent 57 EP studies 2006-2012. Mean age 18.4±11.8 y, all with TCPC type Fontans. 32 ablations, 31 for SVT. VT induced in 5/52 pts studied. No f/u in 19%. In others, median f/u 18 mo.Procedural outcomes of ablation in UVH.47 procedures w/ 54 defined SVT mechanisms. IART 46%, AVNRT 24%, focal 15%, AP 7%, twin AVN 7%. Additional 21 undefined AT. Ablation for SVT acute success 80%. Two major adverse events 6%: death, pulmonary embolus. 50% recurrence short term, improved arrhythmia scores.78% acute success for SVT. 50% recurrence short term; improved arrhythmia scores. 6% major adverse cardiac events. CHD: Catheter Ablation – TGAJones DG2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkpvbmVzPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkpvbmVzPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (332)23219079Retrospective single center9AT ablations TGA Mustard; 9 procedures, 12 circuits between 2007-2012, median age 38 y (18-56 y), used Carto and irrigated tips. Median f/u 15 mo. Ablation outcomes TGA atrial switch ptsTransbaffle puncture in all. AT mechs: CTI dep: 75%, focal 25% (pulmonary venous ?). Acute success 100%; 25% recurrence w/in 16 mo. Death 11% (1/9); recurrent AT w/ CHF. ICD’s in 3/9. Ablation in pulmonary venous atrium needed in all pts. Acute success 100%, recurrence 25% short-term. Wu J2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPld1PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVt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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPld1PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVt
PjQ5MzwvUmVjTnVtPjxJRFRleHQ+QWN1dGUgYW5kIGxvbmctdGVybSBvdXRjb21lIGFmdGVyIGNh
dGhldGVyIGFibGF0aW9uIG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWEgaW4gcGF0aWVu
dHMgYWZ0ZXIgdGhlIE11c3RhcmQgb3IgU2VubmluZyBvcGVyYXRpb24gZm9yIEQtdHJhbnNwb3Np
dGlvbiBvZiB0aGUgZ3JlYXQgYXJ0ZXJpZXM8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFs
Ij48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD40OTM8L1JlZl9JRD48VGl0bGVf
UHJpbWFyeT5BY3V0ZSBhbmQgbG9uZy10ZXJtIG91dGNvbWUgYWZ0ZXIgY2F0aGV0ZXIgYWJsYXRp
b24gb2Ygc3VwcmF2ZW50cmljdWxhciB0YWNoeWNhcmRpYSBpbiBwYXRpZW50cyBhZnRlciB0aGUg
TXVzdGFyZCBvciBTZW5uaW5nIG9wZXJhdGlvbiBmb3IgRC10cmFuc3Bvc2l0aW9uIG9mIHRoZSBn
cmVhdCBhcnRlcmllczwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pld1LEouPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5EZWlzZW5ob2ZlcixJLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+QW1tYXIsUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PkZpY2h0bmVyLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5SZWVu
dHMsVC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlpodSxQLjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+SmlsZWssQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5PktvbGIsQy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkhlc3Ms
Si48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkhlc3NsaW5nLEcuPC9BdXRob3Jz
X1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEzLzY8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QWR1
bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5hZHZlcnNlIGVmZmVjdHM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5hbmFseXNpczwvS2V5d29yZHM+PEtleXdvcmRzPkFydGVyaWVzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5jb21wbGljYXRpb25zPC9L
ZXl3b3Jkcz48S2V5d29yZHM+ZGlhZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+ZXRpb2xvZ3k8
L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5GbHVvcm9zY29w
eTwvS2V5d29yZHM+PEtleXdvcmRzPkdlcm1hbnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5IdW1hbnM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5Mb25naXR1ZGluYWwgU3R1ZGllczwvS2V5d29yZHM+PEtleXdv
cmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
TXlvY2FyZGlhbCBSZXZhc2N1bGFyaXphdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjb25zdHJ1Y3RpdmUgU3VyZ2ljYWwgUHJvY2VkdXJlczwv
S2V5d29yZHM+PEtleXdvcmRzPlJlY3VycmVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZW9wZXJh
dGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNo
eWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFN1cHJhdmVudHJpY3VsYXI8
L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lPC9LZXl3b3Jkcz48S2V5d29yZHM+VHJhbnNwb3NpdGlv
biBvZiBHcmVhdCBWZXNzZWxzPC9LZXl3b3Jkcz48S2V5d29yZHM+VHJlYXRtZW50IE91dGNvbWU8
L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjg4Njwv
U3RhcnRfUGFnZT48RW5kX1BhZ2U+ODkxPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5FdXJvcGFjZTwv
UGVyaW9kaWNhbD48Vm9sdW1lPjE1PC9Wb2x1bWU+PElzc3VlPjY8L0lzc3VlPjxJU1NOX0lTQk4+
MTUzMi0yMDkyPC9JU1NOX0lTQk4+PE1pc2NfMz5ldXM0MDI7MTAuMTA5My9ldXJvcGFjZS9ldXM0
MDI8L01pc2NfMz48QWRkcmVzcz5EZXV0c2NoZXMgSGVyenplbnRydW0gTXVuY2hlbiwgTGF6YXJl
dHRzdHJhc3NlLiAzNiwgODA2MzYgTXVuaWNoLCBHZXJtYW55LiBjYXJkaW9jYXJkaW8yMDAzQHlh
aG9vLmNvbS5jbjwvQWRkcmVzcz48V2ViX1VSTD5QTToyMzM1NTEzMzwvV2ViX1VSTD48WlpfSm91
cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5FdXJvcGFjZSA6IEV1cm9wZWFuIHBhY2luZywgYXJy
aHl0aG1pYXMsIGFuZCBjYXJkaWFjIGVsZWN0cm9waHlzaW9sb2d5IDogam91cm5hbCBvZiB0aGUg
d29ya2luZyBncm91cHMgb24gY2FyZGlhYyBwYWNpbmcsIGFycmh5dGhtaWFzLCBhbmQgY2FyZGlh
YyBjZWxsdWxhciBlbGVjdHJvcGh5c2lvbG9neSBvZiB0aGUgRXVyb3BlYW4gU29jaWV0eSBvZiBD
YXJkaW9sb2d5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFt
ZT0iU3lzdGVtIj5FdXJvcGFjZTwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3Jt
SUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (333)23355133Retrospective single center26Ablation in 26 TGA pts s/p atrial switch repairs, mean age 28.7±6.7 y; 34 ablation procedures. Assess outcomes ablation in TGA atrial switch pts34 AT: IART 88%; AVNRT 12%. Acute success 85% of circuits. Mean f/u 34±24 mo, 30% recurrence IART. TGA atrial switch: high acute success, 34% recurrence <3 yCHD: Surgical therapyPressley JC 1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlByZXNzbGV5PC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlByZXNzbGV5PC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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ADDIN EN.CITE.DATA (334)1394922Retrospective, single center3838 pts, WPW and Ebstein anomly, surgical AP ablation and repair. Mean age 26.3 ±12.3 y, 1968-88. Compared to 384 pts undergoing AP surgery w/o Ebstein. 76% documented AVRT; 42% AF. F/u 6.2± 3.8 y.Assess surgical impact AP ablation during Ebstein repair.Mult AP 50%, right sided 79%, posteroseptal 58%, left 7.9%. Surgery mortality 5.3%, both <15 y old. 28/38 surgery repair + AP ablation; Successful AP ablation: 95%. 82% NS arrhythmias during f/u. Pts w/ Ebstein anomaly improved after surgery w/ AP ablation. Late AF reduced from 42% to 9%, p<.001.Misaki T 1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1pc2FraTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1pc2FraTwvQXV0aG9yPjxZZWFyPjE5OTU8L1llYXI+PFJl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ADDIN EN.CITE.DATA (335)8523883Retrospective, single center4242 pts WPW = Ebstein, surgery 1973-1993. Mean age 35±14 y. 52 APs, 48 right or posteroseptal. Division of AP at surgery; 35 TV operation. Assess outcome WPW surgery in EbsteinAll 52 AP successfully rx at surg. 2 reops due to SVT: additional AP. Hospital mortality 7.1%. no late deaths f/u mean 94 moN/ATheodoro DA1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRoZW9kb3JvPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRoZW9kb3JvPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48
UmVjTnVtPjU3MTwvUmVjTnVtPjxJRFRleHQ+UmlnaHQtc2lkZWQgbWF6ZSBwcm9jZWR1cmUgZm9y
IHJpZ2h0IGF0cmlhbCBhcnJoeXRobWlhcyBpbiBjb25nZW5pdGFsIGhlYXJ0IGRpc2Vhc2U8L0lE
VGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+
PFJlZl9JRD41NzE8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5SaWdodC1zaWRlZCBtYXplIHByb2Nl
ZHVyZSBmb3IgcmlnaHQgYXRyaWFsIGFycmh5dGhtaWFzIGluIGNvbmdlbml0YWwgaGVhcnQgZGlz
ZWFzZTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlRoZW9kb3JvLEQuQS48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkRhbmllbHNvbixHLksuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5Qb3J0ZXIsQy5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+V2FybmVzLEMuQS48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5PjE5OTgv
MTwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jkcz48S2V5d29yZHM+
QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFs
IEZpYnJpbGxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlhbCBGbHV0dGVyPC9LZXl3b3Jk
cz48S2V5d29yZHM+Q2hpbGQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5jb25nZW5pdGFsPC9LZXl3b3Jk
cz48S2V5d29yZHM+RGlzZWFzZTwvS2V5d29yZHM+PEtleXdvcmRzPkVic3RlaW4gQW5vbWFseTwv
S2V5d29yZHM+PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBT
dHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFy
dCBCbG9jazwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IERlZmVjdHMsQ29uZ2VuaXRhbDwvS2V5
d29yZHM+PEtleXdvcmRzPkhlYXJ0IFNlcHRhbCBEZWZlY3RzLEF0cmlhbDwvS2V5d29yZHM+PEtl
eXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluY2lkZW5jZTwvS2V5d29yZHM+PEtl
eXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+TWlkZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaW5uZXNvdGE8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5Nb3JiaWRpdHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5OZXcgWW9yazwvS2V5d29yZHM+
PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UG9zdG9wZXJhdGl2ZSBDb21w
bGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+cHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9L
ZXl3b3Jkcz48S2V5d29yZHM+UXVhbGl0eSBvZiBMaWZlPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVv
cGVyYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+
VHJpY3VzcGlkIFZhbHZlIEluc3VmZmljaWVuY3k8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBG
aWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjE0OTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTUzPC9F
bmRfUGFnZT48UGVyaW9kaWNhbD5Bbm4gVGhvcmFjLlN1cmcuPC9QZXJpb2RpY2FsPjxWb2x1bWU+
NjU8L1ZvbHVtZT48SXNzdWU+MTwvSXNzdWU+PElTU05fSVNCTj4wMDAzLTQ5NzU8L0lTU05fSVNC
Tj48TWlzY18zPlMwMDAzNDk3NTk3MDExOTM0PC9NaXNjXzM+PEFkZHJlc3M+RGl2aXNpb24gb2Yg
Q2FyZGlvdmFzY3VsYXIgYW5kIFRob3JhY2ljIFN1cmdlcnksIE1heW8gQ2xpbmljIGFuZCBNYXlv
IEZvdW5kYXRpb24sIFJvY2hlc3RlciwgTWlubmVzb3RhIDU1OTA1LCBVU0E8L0FkZHJlc3M+PFdl
Yl9VUkw+UE06OTQ1NjEwOTwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVt
Ij5UaGUgQW5uYWxzIG9mIHRob3JhY2ljIHN1cmdlcnk8L2Y+PC9aWl9Kb3VybmFsRnVsbD48Wlpf
Sm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkFubiBUaG9yYWMuU3VyZy48L2Y+PC9a
Wl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+
PC9DaXRlPjwvUmVmbWFuPm==
ADDIN EN.CITE.DATA (336)9456109Retrospective, single center1818 ACHD pts mean age 34.9 y underwent RA Maze for AT/atrial flutter or AF:Ebstein 15, tricuspid regurgitation 2, ASD1. Mean f/u 8 mo. Assess outcome RA maze in ACHDNo early deaths. Early postop SVT 3. RA maze performed, even in pts w/ AF. Inclusion RA maze in ACHD pt w/ RA dilatation and AT is effective in eliminating or reducing AT. Huang CJ 2000 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1YW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj
TnVtPjQzNzwvUmVjTnVtPjxJRFRleHQ+Um9sZSBvZiBlbGVjdHJvcGh5c2lvbG9naWNhbCBzdHVk
aWVzIGFuZCBhcnJoeXRobWlhIGludGVydmVudGlvbiBpbiByZXBhaXJpbmcgRWJzdGVpbiZhcG9z
O3MgYW5vbWFseTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3Vy
bmFsPC9SZWZfVHlwZT48UmVmX0lEPjQzNzwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PlJvbGUgb2Yg
ZWxlY3Ryb3BoeXNpb2xvZ2ljYWwgc3R1ZGllcyBhbmQgYXJyaHl0aG1pYSBpbnRlcnZlbnRpb24g
aW4gcmVwYWlyaW5nIEVic3RlaW4mYXBvcztzIGFub21hbHk8L1RpdGxlX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5IdWFuZyxDLkouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5D
aGl1LEkuUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkxpbixGLlkuPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaGVuLFcuSi48L0F1dGhvcnNfUHJpbWFyeT48
QXV0aG9yc19QcmltYXJ5PkxpbixKLkwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5MbyxILk0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5XdSxNLkguPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DaHUsUy5ILjwvQXV0aG9yc19QcmltYXJ5PjxE
YXRlX1ByaW1hcnk+MjAwMC8xMjwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9L
ZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BcnJoeXRobWlhcyxD
YXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZsdXR0ZXI8L0tleXdvcmRzPjxLZXl3
b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5EZWF0aCxTdWRkZW4sQ2FyZGlhYzwvS2V5d29yZHM+PEtleXdvcmRzPkVic3RlaW4g
QW5vbWFseTwvS2V5d29yZHM+PEtleXdvcmRzPkVsZWN0cm9waHlzaW9sb2d5PC9LZXl3b3Jkcz48
S2V5d29yZHM+ZXRpb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29y
ZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1vcmJpZGl0eTwvS2V5d29yZHM+PEtleXdv
cmRzPm1vcnRhbGl0eTwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5
d29yZHM+cGh5c2lvcGF0aG9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+UG9zdG9wZXJhdGl2ZSBD
b21wbGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJyZW5jZTwvS2V5d29yZHM+PEtl
eXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5TdXJ2aXZhbCBBbmFseXNpczwvS2V5
d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VHJlYXRtZW50
IE91dGNvbWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmljdXNwaWQgVmFsdmU8L0tleXdvcmRzPjxS
ZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjM0NzwvU3RhcnRfUGFnZT48
RW5kX1BhZ2U+MzUwPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5UaG9yYWMuQ2FyZGlvdmFzYy5TdXJn
LjwvUGVyaW9kaWNhbD48Vm9sdW1lPjQ4PC9Wb2x1bWU+PElzc3VlPjY8L0lzc3VlPjxJU1NOX0lT
Qk4+MDE3MS02NDI1PC9JU1NOX0lTQk4+PE1pc2NfMz4xMC4xMDU1L3MtMjAwMC04MzQ4PC9NaXNj
XzM+PEFkZHJlc3M+RGVwYXJ0bWVudCBvZiBTdXJnZXJ5LCBOYXRpb25hbCBUYWl3YW4gVW5pdmVy
c2l0eSBIb3NwaXRhbCwgVGFpcGVpPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjExMTQ1NDAyPC9XZWJf
VVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPlRoZSBUaG9yYWNpYyBhbmQgY2Fy
ZGlvdmFzY3VsYXIgc3VyZ2VvbjwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJi
cmV2PjxmIG5hbWU9IlN5c3RlbSI+VGhvcmFjLkNhcmRpb3Zhc2MuU3VyZy48L2Y+PC9aWl9Kb3Vy
bmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRl
PjwvUmVmbWFuPm==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkh1YW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (337)11145402Retrospective, single center3030 pts w/ Ebstein:surg repair 1973-1997. Preop EP study performed in 11 after 1980: surg ablation performed in 10/11: WPW 4, AVNRT 2, atrial flutter/AF 3, VT1. Assess survival difference w/ op ablation Ebstein. No mort in ablated pts. 7/30 died: 1-infection, 6 died suddenly. None of 6 sudden deaths underwent preop EP study. Detailed preop EP study in Ebstein: “mandatory”:Aggressive surg intervention for arrhythmia may reduce risk of sudden death. Mavroudis C 2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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ADDIN EN.CITE.DATA (338) 11689789Retrospective, single center4040 Fontan conversions w/ arrhythmia surgery; mean age 18.7±9 y. All pts w/ AT; AF in 15.Assess impact of arrhythmia surgery on AT in FontanIsthmus ablation 10 pts, RA Maze 16, Biatrial maze 14. No mortality. Mean f/u 2.5±1.9 y, OHT 7.5%. Arrhythmia recurrence 12.5% Largely AP Fontan population; arrhythmia recurrence 12.5% at 2.5 yDeal BJ2002PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRlYWw8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE.DATA (220) 12147539Retrospective, single center23Comparison isthmus ablation (8) w/ RA maze (15) in AP Fontan pts w/ AT; median age 10.9 y (2-33 y)Assess efficacy of operative ablation techniques Fontan. Isthmus ablation: 62% recurrent AT; f/u 5.6 yRA maze: no recurrence, f/u 2.8 yRA maze superior to isthmus ablation in Fontan ptsKhositseth A2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktob3NpdHNldGg8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktob3NpdHNldGg8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFy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ADDIN EN.CITE.DATA (339)15573066Retrospective single center8383129 adult Ebstein pts w/ SVT underwent arrhy procedure w/ surgery for Ebstein. 41: AP, mean age 18 y; 7 AVNRT, mean 18 y ; 48 atrial flutter/AF (RA maze 38, isthmus 10), mean 33 y. Assess arrhythmia surgery in EbsteinIncidence SVT: atrial flutter/AF 54%, AP 32%, AVNRT 8%. Surgical outcomes: AP or AVNRT: 0 recurrence 48 mo; Atrial flutter/AF 75% freedom from recurrence at 34 mo. Arrhy surg interventions should be added to surgical repair Ebstein in pts w/ SVT: AP, AVNRT, or atrial flutter/AF. AS AT present in 54% and increases w/ age, recommend AT surgery as well as AP surgery.Bockeria L 2005 PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvY2tlcmlhPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48
UmVjTnVtPjQ3NzwvUmVjTnVtPjxJRFRleHQ+QWR2YW50YWdlcyBhbmQgZGlzYWR2YW50YWdlcyBv
ZiBvbmUtc3RhZ2UgYW5kIHR3by1zdGFnZSBzdXJnZXJ5IGZvciBhcnJoeXRobWlhcyBhbmQgRWJz
dGVpbiZhcG9zO3MgYW5vbWFseTwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZf
VHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjQ3NzwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5
PkFkdmFudGFnZXMgYW5kIGRpc2FkdmFudGFnZXMgb2Ygb25lLXN0YWdlIGFuZCB0d28tc3RhZ2Ug
c3VyZ2VyeSBmb3IgYXJyaHl0aG1pYXMgYW5kIEVic3RlaW4mYXBvcztzIGFub21hbHk8L1RpdGxl
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Cb2NrZXJpYSxMLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+R29sdWtob3ZhLEUuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5EYWRhc2hldmEsTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlJldmlz
aHZpbGksQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkxldmFudCxBLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QmF6YWV2LFYuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5SemFldixGLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+S2FrdWNoYXlhLFQuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA1LzEwPC9E
YXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVs
dDwvS2V5d29yZHM+PEtleXdvcmRzPkFycmh5dGhtaWFzLENhcmRpYWM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5DYXJkaWFjIFN1cmdpY2FsIFByb2NlZHVyZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXJk
aW9wdWxtb25hcnkgQnlwYXNzPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248
L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlv
bnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5jb25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+RWJz
dGVpbiBBbm9tYWx5PC9LZXl3b3Jkcz48S2V5d29yZHM+RWNob2NhcmRpb2dyYXBoeTwvS2V5d29y
ZHM+PEtleXdvcmRzPkVsZWN0cm9jYXJkaW9ncmFwaHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1h
bGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhvc3BpdGFs
IE1vcnRhbGl0eTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRz
Pk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+TWlk
ZGxlIEFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5tb3J0YWxpdHk8L0tleXdvcmRzPjxLZXl3b3Jk
cz5wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5d29yZHM+PEtleXdv
cmRzPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9uczwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdl
cnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPlRp
bWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdv
cmRzPldvbGZmLVBhcmtpbnNvbi1XaGl0ZSBTeW5kcm9tZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90
IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+NTM2PC9TdGFydF9QYWdlPjxFbmRfUGFnZT41
NDA8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkV1ci5KIENhcmRpb3Rob3JhYy5TdXJnLjwvUGVyaW9k
aWNhbD48Vm9sdW1lPjI4PC9Wb2x1bWU+PElzc3VlPjQ8L0lzc3VlPjxJU1NOX0lTQk4+MTAxMC03
OTQwPC9JU1NOX0lTQk4+PE1pc2NfMz5TMTAxMC03OTQwKDA1KTAwNTI3LTA7MTAuMTAxNi9qLmVq
Y3RzLjIwMDUuMDQuMDQ3PC9NaXNjXzM+PEFkZHJlc3M+QmFrb3VsZXYgU2NpZW50aWZpYyBDZW50
ZXIgZm9yIENhcmRpb3Zhc2N1bGFyIHN1cmdlcnksIFJ1YmxldnNrb2Ugc2hvc3NlIDEzNSwgTW9z
Y293IDEyMTU1MiwgUnVzc2lhbiBGZWRlcmF0aW9uLiBsZW9hbkBvbmxpbmUucnU8L0FkZHJlc3M+
PFdlYl9VUkw+UE06MTYxNzkxOTM8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5
c3RlbSI+RXVyb3BlYW4gam91cm5hbCBvZiBjYXJkaW8tdGhvcmFjaWMgc3VyZ2VyeSA6IG9mZmlj
aWFsIGpvdXJuYWwgb2YgdGhlIEV1cm9wZWFuIEFzc29jaWF0aW9uIGZvciBDYXJkaW8tdGhvcmFj
aWMgU3VyZ2VyeTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5h
bWU9IlN5c3RlbSI+RXVyLkogQ2FyZGlvdGhvcmFjLlN1cmcuPC9mPjwvWlpfSm91cm5hbFN0ZEFi
YnJldj48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1h
bj5=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJvY2tlcmlhPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (340)16179193Retrospective, single center5353 pts, Ebstein + SVT, mean age 21.6±10.7 y. Surgery + operative ablation: 32 pts; preop RFablation later surg: 21 pt. WPW 26, AVNRT 3, focal 3. Assess combined arrhythmia surgery in Ebstein vs. RFA + surgery.Mortality 3.1% in combined ablation operation vs. 0% in 2 staged. Efficacy: Surgery ablation 94% op vs. 76% catheter.Surgery efficacy WPW 92%, AVNRT 100%, focal 66%. Combined operative ablation + surg repair showed improved AT elimination vs. catheter ablation approach followed by surgery. Giamberti A 2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpYW1iZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpYW1iZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+
PFJlY051bT40MzY8L1JlY051bT48SURUZXh0PkNvbWJpbmVkIGF0cmlhbCBzZXB0YWwgZGVmZWN0
IHN1cmdpY2FsIGNsb3N1cmUgYW5kIGlycmlnYXRlZCByYWRpb2ZyZXF1ZW5jeSBhYmxhdGlvbiBp
biBhZHVsdCBwYXRpZW50czwvSURUZXh0PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlw
ZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjQzNjwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PkNv
bWJpbmVkIGF0cmlhbCBzZXB0YWwgZGVmZWN0IHN1cmdpY2FsIGNsb3N1cmUgYW5kIGlycmlnYXRl
ZCByYWRpb2ZyZXF1ZW5jeSBhYmxhdGlvbiBpbiBhZHVsdCBwYXRpZW50czwvVGl0bGVfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5PkdpYW1iZXJ0aSxBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+Q2hlc3NhLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Gb3Jl
c3RpLFMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BYmVsbGEsUi48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkJ1dGVyYSxHLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+ZGUsVmluY2VudGlpcyBDLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+Q2FybWluYXRpLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5N
ZW5pY2FudGksTC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkZyaWdpb2xhLEEu
PC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA2LzEwPC9EYXRlX1ByaW1hcnk+PEtl
eXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRz
PkFycmh5dGhtaWFzLENhcmRpYWM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmlicmlsbGF0
aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+QXRyaWFsIEZsdXR0ZXI8L0tleXdvcmRzPjxLZXl3b3Jk
cz5DYXJkaW9sb2d5PC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdv
cmRzPjxLZXl3b3Jkcz5jb21wbGljYXRpb25zPC9LZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9L
ZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydCBGYWlsdXJl
PC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgU2VwdGFsIERlZmVjdHMsQXRyaWFsPC9LZXl3b3Jk
cz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5d29yZHM+SXRhbHk8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdv
cmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+bW9ydGFsaXR5PC9LZXl3b3Jkcz48
S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5QZXJpY2FyZGl1bTwvS2V5d29y
ZHM+PEtleXdvcmRzPlJlY3VycmVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3
b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaGVyYXBldXRp
YyBJcnJpZ2F0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PEtleXdv
cmRzPnRyYW5zcGxhbnRhdGlvbjwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJp
bnQ+PFN0YXJ0X1BhZ2U+MTMyNzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTMzMTwvRW5kX1BhZ2U+
PFBlcmlvZGljYWw+QW5uIFRob3JhYy5TdXJnLjwvUGVyaW9kaWNhbD48Vm9sdW1lPjgyPC9Wb2x1
bWU+PElzc3VlPjQ8L0lzc3VlPjxJU1NOX0lTQk4+MTU1Mi02MjU5PC9JU1NOX0lTQk4+PE1pc2Nf
Mz5TMDAwMy00OTc1KDA2KTAwOTMzLTc7MTAuMTAxNi9qLmF0aG9yYWNzdXIuMjAwNi4wNS4wMTA8
L01pc2NfMz48QWRkcmVzcz5QZWRpYXRyaWMgQ2FyZGlvbG9neSBhbmQgQ2FyZGlhYyBTdXJnZXJ5
IERlcGFydG1lbnQsIEdVQ0ggVW5pdCwgRS4gTWFsYW4gQ2VudGVyLCBQb2xpY2xpbmljbyBTYW4g
RG9uYXRvLCBTYW4gRG9uYXRvIE1pbGFuZXNlLCBJdGFseS4gYWxlZ2lhQGhvdG1haWwuY29tPC9B
ZGRyZXNzPjxXZWJfVVJMPlBNOjE2OTk2OTI4PC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBu
YW1lPSJTeXN0ZW0iPlRoZSBBbm5hbHMgb2YgdGhvcmFjaWMgc3VyZ2VyeTwvZj48L1paX0pvdXJu
YWxGdWxsPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+QW5uIFRob3JhYy5T
dXJnLjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zv
cm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (341)16996928Retrospective, single center1515 ASD pts, >40 y, surgical closure ASD w/ intraop RF ablation. All SVT: 8 AF, 7 AT/atrial flutter. 2002-2004. RA Maze 8, biatrial cox maze iii 7 pts. F/u mean 24 mo. Assess op ablation AT in ASD ptsNo mortality, one pacemaker. AF recurrentce 6.5%, no AT recurrence. Rec add intraop RF ablation to surgical ASD closure, safe & effective. Karamlou T 2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthcmFtbG91PC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthcmFtbG91PC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48
UmVjTnVtPjU1NDwvUmVjTnVtPjxJRFRleHQ+T3V0Y29tZXMgYWZ0ZXIgbGF0ZSByZW9wZXJhdGlv
biBpbiBwYXRpZW50cyB3aXRoIHJlcGFpcmVkIHRldHJhbG9neSBvZiBGYWxsb3Q6IHRoZSBpbXBh
Y3Qgb2YgYXJyaHl0aG1pYSBhbmQgYXJyaHl0aG1pYSBzdXJnZXJ5PC9JRFRleHQ+PE1ETCBSZWZf
VHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+NTU0PC9S
ZWZfSUQ+PFRpdGxlX1ByaW1hcnk+T3V0Y29tZXMgYWZ0ZXIgbGF0ZSByZW9wZXJhdGlvbiBpbiBw
YXRpZW50cyB3aXRoIHJlcGFpcmVkIHRldHJhbG9neSBvZiBGYWxsb3Q6IHRoZSBpbXBhY3Qgb2Yg
YXJyaHl0aG1pYSBhbmQgYXJyaHl0aG1pYSBzdXJnZXJ5PC9UaXRsZV9QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+S2FyYW1sb3UsVC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNp
bGJlcixJLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGFvLFIuPC9BdXRob3Jz
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5NY0NyaW5kbGUsQi5XLjwvQXV0aG9yc19QcmltYXJ5
PjxBdXRob3JzX1ByaW1hcnk+SGFycmlzLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5Eb3duYXIsRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PldlYmIsRy5E
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q29sbWFuLEouTS48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlZhbiBBcnNkZWxsLEcuUy48L0F1dGhvcnNfUHJpbWFy
eT48QXV0aG9yc19QcmltYXJ5PldpbGxpYW1zLFcuRy48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9Q
cmltYXJ5PjIwMDYvNTwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5BZG9sZXNjZW50PC9LZXl3b3Jk
cz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BcnJoeXRobWlhcyxDYXJkaWFj
PC9LZXl3b3Jkcz48S2V5d29yZHM+Q2FuYWRhPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2hpbGQ8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5DaGlsZCxQcmVzY2hvb2w8L0tleXdvcmRzPjxLZXl3b3Jkcz5Db21v
cmJpZGl0eTwvS2V5d29yZHM+PEtleXdvcmRzPkVjaG9jYXJkaW9ncmFwaHksRG9wcGxlcixDb2xv
cjwvS2V5d29yZHM+PEtleXdvcmRzPmVwaWRlbWlvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkZl
bWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZmFu
dDwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+bW9ydGFsaXR5PC9LZXl3b3Jkcz48S2V5d29yZHM+T250YXJpbzwv
S2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+cHJldmVudGlv
biAmYW1wOyBjb250cm9sPC9LZXl3b3Jkcz48S2V5d29yZHM+UHVsbW9uYXJ5IEF0cmVzaWE8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5QdWxtb25hcnkgVmFsdmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1
cnJlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVvcGVyYXRpb248L0tleXdvcmRzPjxLZXl3b3Jk
cz5SaXNrPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzayBGYWN0b3JzPC9LZXl3b3Jkcz48S2V5d29y
ZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5
d29yZHM+VGFjaHljYXJkaWEsU3VwcmF2ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPlRl
dHJhbG9neSBvZiBGYWxsb3Q8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPlRyaWN1
c3BpZCBWYWx2ZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0
X1BhZ2U+MTc4NjwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTc5MzwvRW5kX1BhZ2U+PFBlcmlvZGlj
YWw+QW5uIFRob3JhYy5TdXJnLjwvUGVyaW9kaWNhbD48Vm9sdW1lPjgxPC9Wb2x1bWU+PElzc3Vl
PjU8L0lzc3VlPjxJU1NOX0lTQk4+MTU1Mi02MjU5PC9JU1NOX0lTQk4+PE1pc2NfMz5TMDAwMy00
OTc1KDA1KTAyMjg1LVg7MTAuMTAxNi9qLmF0aG9yYWNzdXIuMjAwNS4xMi4wMzk8L01pc2NfMz48
QWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBIb3NwaXRhbCBmb3Ig
U2ljayBDaGlsZHJlbiwgVG9yb250bywgT250YXJpbywgQ2FuYWRhPC9BZGRyZXNzPjxXZWJfVVJM
PlBNOjE2NjMxNjczPC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPlRo
ZSBBbm5hbHMgb2YgdGhvcmFjaWMgc3VyZ2VyeTwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Kb3Vy
bmFsU3RkQWJicmV2PjxmIG5hbWU9IlN5c3RlbSI+QW5uIFRob3JhYy5TdXJnLjwvZj48L1paX0pv
dXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0Np
dGU+PC9SZWZtYW4+AG==
ADDIN EN.CITE.DATA (342)16631673Retrospective, single center2491969-2005, TOF or DORV pts undergoing reop for PVR or TVR; AT in 41 pts. Median age 23 y. Assess RA maze vs. no maze on late outcome. Assess impact of RA ablation on arrhythmia outcomes TOF.Atrial flutter: isthmus ablation; AF RA maze. AT recurrence: ablation pts, 9%, vs. 78% AT occurence in non-ablation; 7.5 y. AT pts older, longer QRS durationRA Maze at time of surgery improved long term AT free status. QRS duration >160 msec predicted risk of AT in TOFStulak JM2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0dWxhazwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0dWxhazwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl
Y051bT41NTI8L1JlY051bT48SURUZXh0PlJpZ2h0LXNpZGVkIE1hemUgcHJvY2VkdXJlIGZvciBh
dHJpYWwgdGFjaHlhcnJoeXRobWlhcyBpbiBjb25nZW5pdGFsIGhlYXJ0IGRpc2Vhc2U8L0lEVGV4
dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJl
Zl9JRD41NTI8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5SaWdodC1zaWRlZCBNYXplIHByb2NlZHVy
ZSBmb3IgYXRyaWFsIHRhY2h5YXJyaHl0aG1pYXMgaW4gY29uZ2VuaXRhbCBoZWFydCBkaXNlYXNl
PC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U3R1bGFrLEouTS48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PkRlYXJhbmksSi5BLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+UHVnYSxGLkouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5a
ZWhyLEsuSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNjaGFmZixILlYuPC9B
dXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5EYW5pZWxzb24sRy5LLjwvQXV0aG9yc19Q
cmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwNi81PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkb2xl
c2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8
L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmx1dHRlcjwvS2V5d29yZHM+PEtleXdvcmRzPkNh
cmRpYWMgU3VyZ2ljYWwgUHJvY2VkdXJlczwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkPC9LZXl3
b3Jkcz48S2V5d29yZHM+Q29tb3JiaWRpdHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5jb25nZW5pdGFs
PC9LZXl3b3Jkcz48S2V5d29yZHM+RGlzZWFzZTwvS2V5d29yZHM+PEtleXdvcmRzPkVic3RlaW4g
QW5vbWFseTwvS2V5d29yZHM+PEtleXdvcmRzPmVwaWRlbWlvbG9neTwvS2V5d29yZHM+PEtleXdv
cmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48S2V5d29yZHM+
SGVhcnQgRGVmZWN0cyxDb25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgU2VwdGFs
IERlZmVjdHMsQXRyaWFsPC9LZXl3b3Jkcz48S2V5d29yZHM+SHVtYW5zPC9LZXl3b3Jkcz48S2V5
d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPk1pbm5lc290YTwvS2V5d29yZHM+PEtl
eXdvcmRzPk5ldyBZb3JrPC9LZXl3b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5RdWFsaXR5IG9mIExpZmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWN1cnJlbmNlPC9L
ZXl3b3Jkcz48S2V5d29yZHM+c3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPlN1cnZpdm9yczwv
S2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VGV0cmFs
b2d5IG9mIEZhbGxvdDwvS2V5d29yZHM+PEtleXdvcmRzPlRpbWU8L0tleXdvcmRzPjxLZXl3b3Jk
cz5UcmljdXNwaWQgVmFsdmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmljdXNwaWQgVmFsdmUgSW5z
dWZmaWNpZW5jeTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0
X1BhZ2U+MTc4MDwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+MTc4NDwvRW5kX1BhZ2U+PFBlcmlvZGlj
YWw+QW5uIFRob3JhYy5TdXJnLjwvUGVyaW9kaWNhbD48Vm9sdW1lPjgxPC9Wb2x1bWU+PElzc3Vl
PjU8L0lzc3VlPjxJU1NOX0lTQk4+MTU1Mi02MjU5PC9JU1NOX0lTQk4+PE1pc2NfMz5TMDAwMy00
OTc1KDA1KTAxOTYyLTQ7MTAuMTAxNi9qLmF0aG9yYWNzdXIuMjAwNS4xMC4wNDY8L01pc2NfMz48
QWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBNYXlvIENsaW5pYyBh
bmQgRm91bmRhdGlvbiwgUm9jaGVzdGVyLCBNaW5uZXNvdGEgNTU5MDUsIFVTQTwvQWRkcmVzcz48
V2ViX1VSTD5QTToxNjYzMTY3MjwvV2ViX1VSTD48WlpfSm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lz
dGVtIj5UaGUgQW5uYWxzIG9mIHRob3JhY2ljIHN1cmdlcnk8L2Y+PC9aWl9Kb3VybmFsRnVsbD48
WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1lPSJTeXN0ZW0iPkFubiBUaG9yYWMuU3VyZy48L2Y+
PC9aWl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9N
REw+PC9DaXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (343)16631672Retrospective, single center991993-2003, 99 pts RA maze w/ ACHD repair. Median age 43 y. Did not distinguish between AT and AF. Ebsteins 47, TR 19, UVH 11, ASD 8, TOF 8, other 6. Impact arrhythmia surgery on AT: ACHD. 6% early mortality. 28% early ATArrhythmia recurrence 7%, f/u 2.7 y; AA medications 55%.ACHD: 55% on AA meds; 93% not in AT at 2.7 yMavroudis C 2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+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ADDIN EN.CITE.DATA (344)17954046Retrospective, single center1111994-2007, 111 Fontan conversions w/ arrhythmia surgery; mean age 22.5 y. Mainly AP Fontan. Assess arrhythmia recurrence, survival FontanEarly mortality 0.9%, late death/OHT 11%. Late AT 13.5%, f/u 7.9 yLate AT in Fontan 13.5% at ~ 8 y;Giamberti A2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpYW1iZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdpYW1iZXJ0aTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN EN.CITE.DATA (345)17689722Retrospective, single center5050 ACHD adults undergoing surgery; mean age 39 y. 31 RA Maze, 13 biatrial, 6 VT ablations.Assess surgical arrhythmia outcome ACHD.Mortality 4%; Mean f/u 28 mo: 4/48 on medications; 43 sinus rhythm, 4 recurrent AFACHD: 86% sinus rhythm, no medications during short term f/uMavroudis C 2008PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hdnJvdWRpczwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN EN.CITE.DATA (346)18721574Retrospective, single center100Arrhythmia operations, 11 no HD; 89 associated CHD (33 UVH); mean age 15.9 y. SVT 87, VT 13Assess surgical arrhythmia outcome ACHDMechs AT: ART 45, AF 11, AC 19, AVNRT 6, Focal 6; early mortality 3%, late death/OHT 6%; 10 y Freedom from AT 85%, 68% VTFreedom from AT at 10 y: 85% in mixed population ACHDAboulhosn J2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFib3VsaG9zbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkFib3VsaG9zbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+
PFJlY051bT41NTU8L1JlY051bT48SURUZXh0PkFycmh5dGhtaWEgcmVjdXJyZW5jZSBpbiBhZHVs
dCBwYXRpZW50cyB3aXRoIHNpbmdsZSB2ZW50cmljbGUgcGh5c2lvbG9neSBmb2xsb3dpbmcgc3Vy
Z2ljYWwgRm9udGFuIGNvbnZlcnNpb248L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48
UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD41NTU8L1JlZl9JRD48VGl0bGVfUHJp
bWFyeT5BcnJoeXRobWlhIHJlY3VycmVuY2UgaW4gYWR1bHQgcGF0aWVudHMgd2l0aCBzaW5nbGUg
dmVudHJpY2xlIHBoeXNpb2xvZ3kgZm9sbG93aW5nIHN1cmdpY2FsIEZvbnRhbiBjb252ZXJzaW9u
PC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QWJvdWxob3NuLEouPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5XaWxsaWFtcyxSLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+U2hpdmt1bWFyLEsuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5CYXJrb3dza2ksUi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlBsdW5rZXR0
LE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5NaW5lcixQLjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+SG91c2VyLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5MYWtzLEguPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5SZWVt
dHNlbixCLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2hhbm5vbixLLjwvQXV0
aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hpbGQsSi48L0F1dGhvcnNfUHJpbWFyeT48
RGF0ZV9QcmltYXJ5PjIwMTAvOTwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5hYm5vcm1hbGl0aWVz
PC9LZXl3b3Jkcz48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0
PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+
QXJ0ZXJpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+
PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5jb25nZW5pdGFsPC9L
ZXl3b3Jkcz48S2V5d29yZHM+RGlzZWFzZTwvS2V5d29yZHM+PEtleXdvcmRzPmV0aW9sb2d5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+Rm9udGFuIFByb2Nl
ZHVyZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0PC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQg
RGVmZWN0cyxDb25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgVmVudHJpY2xlczwv
S2V5d29yZHM+PEtleXdvcmRzPkhvc3BpdGFsIE1vcnRhbGl0eTwvS2V5d29yZHM+PEtleXdvcmRz
Pkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluY2lkZW5jZTwvS2V5d29yZHM+PEtleXdvcmRz
PkxvcyBBbmdlbGVzPC9LZXl3b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRz
Pm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdv
cmRzPk1vcmJpZGl0eTwvS2V5d29yZHM+PEtleXdvcmRzPm1vcnRhbGl0eTwvS2V5d29yZHM+PEtl
eXdvcmRzPk5ldyBZb3JrPC9LZXl3b3Jkcz48S2V5d29yZHM+UGFsbGlhdGl2ZSBDYXJlPC9LZXl3
b3Jkcz48S2V5d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9sb2d5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJyZW5jZTwvS2V5d29yZHM+PEtleXdvcmRzPlJldHJvc3Bl
Y3RpdmUgU3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2s8L0tleXdvcmRzPjxLZXl3b3Jk
cz5SaXNrIEFzc2Vzc21lbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrIEZhY3RvcnM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3Vw
cmF2ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPlRpbWUgRmFjdG9yczwvS2V5d29yZHM+
PEtleXdvcmRzPnRyYW5zcGxhbnRhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPlRyZWF0bWVudCBP
dXRjb21lPC9LZXl3b3Jkcz48S2V5d29yZHM+WW91bmcgQWR1bHQ8L0tleXdvcmRzPjxSZXByaW50
Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjQzMDwvU3RhcnRfUGFnZT48RW5kX1Bh
Z2U+NDM0PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5Db25nZW5pdC5IZWFydCBEaXMuPC9QZXJpb2Rp
Y2FsPjxWb2x1bWU+NTwvVm9sdW1lPjxJc3N1ZT41PC9Jc3N1ZT48SVNTTl9JU0JOPjE3NDctMDgw
MzwvSVNTTl9JU0JOPjxNaXNjXzM+Q0hENDQzOzEwLjExMTEvai4xNzQ3LTA4MDMuMjAxMC4wMDQ0
My54PC9NaXNjXzM+PEFkZHJlc3M+QWhtYW5zb24vVUNMQSBBZHVsdCBDb25nZW5pdGFsIEhlYXJ0
IERpc2Vhc2UgQ2VudGVyLCBVQ0xBIE1lZGljYWwgQ2VudGVyLCBCSC0zMDcgQ0hTLCA2NTAgQ2hh
cmxlcyBZb3VuZyBEcml2ZSBTb3V0aCwgTG9zIEFuZ2VsZXMsIENBLCBVU0EuIGphYm91bGhvc25A
bWVkbmV0LnVjbGEuZWR1PC9BZGRyZXNzPjxXZWJfVVJMPlBNOjIxMDg3NDI3PC9XZWJfVVJMPjxa
Wl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPkNvbmdlbml0LkhlYXJ0IERpcy48L2Y+PC9a
Wl9Kb3VybmFsRnVsbD48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3JrZm9ybUlEPjwvTURMPjwvQ2l0
ZT48L1JlZm1hbj5=
ADDIN EN.CITE.DATA (347)21087427Retrospective, single center2727 atriopulm Fontan adults converted to TCPC; 67% extracardiac. 89% w/ atrial tach. 21/27 w/ arrhythmia surg: RA 12, RA + LA 9. Mean age 30 y (18-52 y)Mean f/u 4.2 y. Assess arrhythmia recurrence after Fontan arrhythmia surgery. Operative mortality 7.4%. Arrhythmia recurrence 14% (3/21)PLE 3; 1 died 27 mo postop, 2 resolved.Recurrrent AT in 14% w/ 4 y f/uGutierrez SD2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1dGllcnJlejwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+
PFJlY051bT41NzA8L1JlY051bT48SURUZXh0PkF0cmlhbCB0YWNoeWFycmh5dGhtaWFzIGFuZCB0
aGUgQ294LW1hemUgcHJvY2VkdXJlIGluIGNvbmdlbml0YWwgaGVhcnQgZGlzZWFzZTwvSURUZXh0
PjxNREwgUmVmX1R5cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVm
X0lEPjU3MDwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PkF0cmlhbCB0YWNoeWFycmh5dGhtaWFzIGFu
ZCB0aGUgQ294LW1hemUgcHJvY2VkdXJlIGluIGNvbmdlbml0YWwgaGVhcnQgZGlzZWFzZTwvVGl0
bGVfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkd1dGllcnJleixTLkQuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5FYXJpbmcsTS5HLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+U2luZ2gsQS5LLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VHdl
ZGRlbGwsSi5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QmFydHosUC5KLjwv
QXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAxMy85PC9EYXRlX1ByaW1hcnk+PEtleXdv
cmRzPkFkb2xlc2NlbnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZHVsdDwvS2V5d29yZHM+PEtleXdv
cmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmlicmlsbGF0aW9uPC9LZXl3b3Jk
cz48S2V5d29yZHM+QXRyaWFsIEZsdXR0ZXI8L0tleXdvcmRzPjxLZXl3b3Jkcz5DYXRoZXRlciBB
YmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5jb25nZW5pdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+RGlzZWFzZTwvS2V5d29yZHM+PEtl
eXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVzPC9LZXl3
b3Jkcz48S2V5d29yZHM+Rm9udGFuIFByb2NlZHVyZTwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0
PC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgRGVmZWN0cyxDb25nZW5pdGFsPC9LZXl3b3Jkcz48
S2V5d29yZHM+SGVhcnQgRGlzZWFzZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydCBTZXB0YWwg
RGVmZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IFNlcHRhbCBEZWZlY3RzLEF0cmlhbDwv
S2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdv
cmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPk1vcmJpZGl0eTwv
S2V5d29yZHM+PEtleXdvcmRzPm1vcnRhbGl0eTwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UGVkaWF0cmljczwvS2V5d29yZHM+PEtleXdvcmRzPlBvc3Rv
cGVyYXRpdmUgQ29tcGxpY2F0aW9uczwvS2V5d29yZHM+PEtleXdvcmRzPlJldHJvc3BlY3RpdmUg
U3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5T
dXJ2aXZvcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdv
cmRzPlRldHJhbG9neSBvZiBGYWxsb3Q8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lPC9LZXl3b3Jk
cz48S2V5d29yZHM+VHJpY3VzcGlkIFZhbHZlPC9LZXl3b3Jkcz48S2V5d29yZHM+V2lzY29uc2lu
PC9LZXl3b3Jkcz48S2V5d29yZHM+WW91bmcgQWR1bHQ8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBp
biBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjQzNDwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+NDM5
PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5Db25nZW5pdC5IZWFydCBEaXMuPC9QZXJpb2RpY2FsPjxW
b2x1bWU+ODwvVm9sdW1lPjxJc3N1ZT41PC9Jc3N1ZT48SVNTTl9JU0JOPjE3NDctMDgwMzwvSVNT
Tl9JU0JOPjxNaXNjXzM+MTAuMTExMS9jaGQuMTIwMzE8L01pc2NfMz48QWRkcmVzcz5EZXBhcnRt
ZW50IG9mIFBlZGlhdHJpY3MgYW5kIEludGVybmFsIE1lZGljaW5lLCBNZWRpY2FsIENvbGxlZ2Ug
b2YgV2lzY29uc2luLCBNaWx3YXVrZWUsIFdpcywgVVNBPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjIz
MjgwMjQyPC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPkNvbmdlbml0
LkhlYXJ0IERpcy48L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfV29ya2Zvcm1JRD4xPC9aWl9Xb3Jr
Zm9ybUlEPjwvTURMPjwvQ2l0ZT48L1JlZm1hbj4A
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkd1dGllcnJlejwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+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ADDIN EN.CITE.DATA (348)23280242Retrospective, single center2424 ACHD pts w/ AA undergoing surgery, mean age 40.9 y; incorporated cox maze procedure. 2004-2010. TOF 8, AVSD 4; RVOT repair 10, TV repair 8, ASD 7. Mean F/u 2.8 y, (.1-5.7 y). Assess outcome of cox maze procedure in ACHDPreop AT: 19, AF 5. Mortality: 16.5%, (12.5% early, 1 late)74% of survivors arrhythmia free. Pts w/ CHD and atrial arrhythmias, majority free of arrhythmias w Cox Maze procedure. Terrada T2013PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlcmFkYTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl
Y051bT41NzI8L1JlY051bT48SURUZXh0PlN1cmdpY2FsIG91dGNvbWUgb2YgRm9udGFuIGNvbnZl
cnNpb24gYW5kIGFycmh5dGhtaWEgc3VyZ2VyeTogTmVlZCBhIHBhY2VtYWtlcj88L0lEVGV4dD48
TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9J
RD41NzI8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5TdXJnaWNhbCBvdXRjb21lIG9mIEZvbnRhbiBj
b252ZXJzaW9uIGFuZCBhcnJoeXRobWlhIHN1cmdlcnk6IE5lZWQgYSBwYWNlbWFrZXI/PC9UaXRs
ZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VGVyYWRhLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5TYWt1cmFpLEguPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5Ob25ha2EsVC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNha3VyYWksVC48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN1Z2l1cmEsSi48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PlRhbmVpY2hpLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5PaHRzdWthLFIuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEz
LzExLzU8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QXJ0ZXJpZXM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5CcmFkeWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb250YW4gUHJvY2VkdXJl
PC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJy
ZW5jZTwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrIEZh
Y3RvcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGlt
ZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+Njgy
PC9TdGFydF9QYWdlPjxFbmRfUGFnZT42ODY8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFzaWFuIENh
cmRpb3Zhc2MuVGhvcmFjLkFubi48L1BlcmlvZGljYWw+PFZvbHVtZT4yMjwvVm9sdW1lPjxJc3N1
ZT42PC9Jc3N1ZT48SVNTTl9JU0JOPjE4MTYtNTM3MDwvSVNTTl9JU0JOPjxNaXNjXzM+MDIxODQ5
MjMxMzUwNDkzOTsxMC4xMTc3LzAyMTg0OTIzMTM1MDQ5Mzk8L01pc2NfMz48QWRkcmVzcz5EZXBh
cnRtZW50IG9mIENhcmRpb3Zhc2N1bGFyIFN1cmdlcnksIENodWt5byBIb3NwaXRhbCwgQWljaGks
IEphcGFuIHRha2FmdW1pX3RlcmFkYUBjaHVreW8taG9zcC5qcCYjeEE7RGVwYXJ0bWVudCBvZiBD
YXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7
RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFp
Y2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVr
eW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxh
ciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBv
ZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYj
eEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWws
IEFpY2hpLCBKYXBhbjwvQWRkcmVzcz48V2ViX1VSTD5QTToyNDg4Nzg5MTwvV2ViX1VSTD48Wlpf
Sm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5Bc2lhbiBjYXJkaW92YXNjdWxhciAmYW1wOyB0
aG9yYWNpYyBhbm5hbHM8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48
ZiBuYW1lPSJTeXN0ZW0iPkFzaWFuIENhcmRpb3Zhc2MuVGhvcmFjLkFubi48L2Y+PC9aWl9Kb3Vy
bmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRl
PjwvUmVmbWFuPm==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlRlcmFkYTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl
Y051bT41NzI8L1JlY051bT48SURUZXh0PlN1cmdpY2FsIG91dGNvbWUgb2YgRm9udGFuIGNvbnZl
cnNpb24gYW5kIGFycmh5dGhtaWEgc3VyZ2VyeTogTmVlZCBhIHBhY2VtYWtlcj88L0lEVGV4dD48
TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9J
RD41NzI8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5TdXJnaWNhbCBvdXRjb21lIG9mIEZvbnRhbiBj
b252ZXJzaW9uIGFuZCBhcnJoeXRobWlhIHN1cmdlcnk6IE5lZWQgYSBwYWNlbWFrZXI/PC9UaXRs
ZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+VGVyYWRhLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5TYWt1cmFpLEguPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5Ob25ha2EsVC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNha3VyYWksVC48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlN1Z2l1cmEsSi48L0F1dGhvcnNfUHJp
bWFyeT48QXV0aG9yc19QcmltYXJ5PlRhbmVpY2hpLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhv
cnNfUHJpbWFyeT5PaHRzdWthLFIuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDEz
LzExLzU8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QXJ0ZXJpZXM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5CcmFkeWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPmNvbXBsaWNhdGlvbnM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb250YW4gUHJvY2VkdXJl
PC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPlBhdGllbnRz
PC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvZ25vc2lzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVjdXJy
ZW5jZTwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2s8L0tleXdvcmRzPjxLZXl3b3Jkcz5SaXNrIEZh
Y3RvcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGlt
ZTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1BhZ2U+Njgy
PC9TdGFydF9QYWdlPjxFbmRfUGFnZT42ODY8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPkFzaWFuIENh
cmRpb3Zhc2MuVGhvcmFjLkFubi48L1BlcmlvZGljYWw+PFZvbHVtZT4yMjwvVm9sdW1lPjxJc3N1
ZT42PC9Jc3N1ZT48SVNTTl9JU0JOPjE4MTYtNTM3MDwvSVNTTl9JU0JOPjxNaXNjXzM+MDIxODQ5
MjMxMzUwNDkzOTsxMC4xMTc3LzAyMTg0OTIzMTM1MDQ5Mzk8L01pc2NfMz48QWRkcmVzcz5EZXBh
cnRtZW50IG9mIENhcmRpb3Zhc2N1bGFyIFN1cmdlcnksIENodWt5byBIb3NwaXRhbCwgQWljaGks
IEphcGFuIHRha2FmdW1pX3RlcmFkYUBjaHVreW8taG9zcC5qcCYjeEE7RGVwYXJ0bWVudCBvZiBD
YXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7
RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFp
Y2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVr
eW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxh
ciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYjeEE7RGVwYXJ0bWVudCBv
ZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWwsIEFpY2hpLCBKYXBhbiYj
eEE7RGVwYXJ0bWVudCBvZiBDYXJkaW92YXNjdWxhciBTdXJnZXJ5LCBDaHVreW8gSG9zcGl0YWws
IEFpY2hpLCBKYXBhbjwvQWRkcmVzcz48V2ViX1VSTD5QTToyNDg4Nzg5MTwvV2ViX1VSTD48Wlpf
Sm91cm5hbEZ1bGw+PGYgbmFtZT0iU3lzdGVtIj5Bc2lhbiBjYXJkaW92YXNjdWxhciAmYW1wOyB0
aG9yYWNpYyBhbm5hbHM8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48
ZiBuYW1lPSJTeXN0ZW0iPkFzaWFuIENhcmRpb3Zhc2MuVGhvcmFjLkFubi48L2Y+PC9aWl9Kb3Vy
bmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRl
PjwvUmVmbWFuPm==
ADDIN EN.CITE.DATA (349)24887891Retrospective, single center2525 consecutive pts undergoing Fontan conversion 1/04-3/12. Mean age 21 6.3 y. 24/25 underwent arrhyth surg: RA maze 15, isthmus 3, biatrial 6. Mean f/u 21 mo(11-86 mo)Assess outcome Fontan arrhythmia surgery.Late AT recurrence 12.5%Operative mortality: 0. 16/25 no pacemaker implanted. 5 pts reoperation to implant pacer. Recurrent AT 12. 5%, Said SM2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhaWQ8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhaWQ8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (350)24786860Retrospective, single center7070 Fontan pts underwent Fontan conversion 1994-2011. Median age 23 y (4-46 y)AT present 89%TCPC intra-atrial 59%; extracardiac 26%, Lateral tunnel 16%. 49/70 arrhythmia surgery. Mean f/u 5 y. Assess outcome Fontan arrhythmia surgery.Late Recurrent AT in 16% of pts w/ arrhythmia surgeryOperative mortality 14%. 10 y survival 67%Periop death predictors: Age >27 y, AV valve regurgitation, males. PLE improved in 1/7 pts. Late Recurrent AT in 16%Pregnancy: Acute Conversion of AV Node-Dependent Tachycardia Ghosh N2011 ADDIN REFMGR.CITE <Refman><Cite><Author>Ghosh</Author><Year>2011</Year><RecNum>114</RecNum><IDText>The acute treatment of maternal supraventricular tachycardias during pregnancy: a review of the literature</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>114</Ref_ID><Title_Primary>The acute treatment of maternal supraventricular tachycardias during pregnancy: a review of the literature</Title_Primary><Authors_Primary>Ghosh,N.</Authors_Primary><Authors_Primary>Luk,A.</Authors_Primary><Authors_Primary>Derzko,C.</Authors_Primary><Authors_Primary>Dorian,P.</Authors_Primary><Authors_Primary>Chow,C.M.</Authors_Primary><Date_Primary>2011/1</Date_Primary><Keywords>Adenosine</Keywords><Keywords>Adrenergic beta-Antagonists</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Calcium Channel Blockers</Keywords><Keywords>Cohort Studies</Keywords><Keywords>drug therapy</Keywords><Keywords>Electric Countershock</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Pregnancy</Keywords><Keywords>Pregnancy Complications,Cardiovascular</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>17</Start_Page><End_Page>23</End_Page><Periodical>J Obstet.Gynaecol.Can</Periodical><Volume>33</Volume><Issue>1</Issue><ISSN_ISBN>1701-2163</ISSN_ISBN><Address>Department of Medicine, St. Michael's Hospital, Toronto ON</Address><Web_URL>PM:21272431</Web_URL><ZZ_JournalFull><f name="System">Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Obstet.Gynaecol.Can</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(351)21272431Review of all reports published 1950-2010 on acute termination of SVT138 ptsVariety of drugs. Most common adenosine w/ 58 cases. Also electrical DCCV 18 casesSuccessful termination of SVTAdenosine was most successful at terminating SVT. Beta blockers and verapamil second, led to more hypotension. Antiarrhythmic drugs not very effective.Variety of interventions was reported on acute termination of SVT. Most common adenosine w/ 58 cases. Also electrical DCCV 18 cases, verapamil 16 cases and beta blockers 13 cases. Diversity of antiarrhythmic drugs as well. Most effective was adenosine w/ 84% success, followed by beta blockers and verapamil. Cardioversion safe.Pregnancy: Catheter AblationDamilakis J2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhbWlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhbWlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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 EN.CITE.DATA (352)11514375Conceptus radiation dose and risk determination for catheter ablation procedures.2020 women of childbearing ages who underwent ablation proceduresEstimation of radiation dose using phantom pregnancyTypical dose to conceptus was <1 mGyA typical ablation procedure results in very small increase in risk of harmful effects to the conceptus.Berruezo A2007 ADDIN REFMGR.CITE <Refman><Cite><Author>Berruezo</Author><Year>2007</Year><RecNum>115</RecNum><IDText>Low exposure radiation with conventional guided radiofrequency catheter ablation in pregnant women</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>115</Ref_ID><Title_Primary>Low exposure radiation with conventional guided radiofrequency catheter ablation in pregnant women</Title_Primary><Authors_Primary>Berruezo,A.</Authors_Primary><Authors_Primary>Diez,G.R.</Authors_Primary><Authors_Primary>Berne,P.</Authors_Primary><Authors_Primary>Esteban,M.</Authors_Primary><Authors_Primary>Mont,L.</Authors_Primary><Authors_Primary>Brugada,J.</Authors_Primary><Date_Primary>2007/10</Date_Primary><Keywords>Adult</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Female</Keywords><Keywords>Fetus</Keywords><Keywords>Fluoroscopy</Keywords><Keywords>Humans</Keywords><Keywords>Pregnancy</Keywords><Keywords>Pregnancy Complications,Cardiovascular</Keywords><Keywords>Radiation Dosage</Keywords><Keywords>radiation effects</Keywords><Keywords>Spain</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>1299</Start_Page><End_Page>1302</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>30</Volume><Issue>10</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Misc_3>PACE858;10.1111/j.1540-8159.2007.00858.x</Misc_3><Address>Arrhythmia Section, Cardiology Department, Thorax Institute, Hospital Clinic, Barcelona, Spain. berruezo@clinic.ub.es</Address><Web_URL>PM:17897139</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(353)17897139Case report of ablation w/ low radiation exposure2 ptsPt w/ drug refractory SVT; ablation of SVT w/ radiation dosimeterSuccessful ablation; adverse effectsAll pathways eliminated successfullyBoth pts treated, fetus dose was very low, below dangerous limit.Szumowski2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN6dW1vd3NraTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+
PFJlY051bT4xMTY8L1JlY051bT48SURUZXh0PkFibGF0aW9uIG9mIHNldmVyZSBkcnVnLXJlc2lz
dGFudCB0YWNoeWFycmh5dGhtaWEgZHVyaW5nIHByZWduYW5jeTwvSURUZXh0PjxNREwgUmVmX1R5
cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjExNjwvUmVm
X0lEPjxUaXRsZV9QcmltYXJ5PkFibGF0aW9uIG9mIHNldmVyZSBkcnVnLXJlc2lzdGFudCB0YWNo
eWFycmh5dGhtaWEgZHVyaW5nIHByZWduYW5jeTwvVGl0bGVfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlN6dW1vd3NraSxMLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U3p1Zmxh
ZG93aWN6LEUuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5PcmN6eWtvd3NraSxN
LjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Qm9kYWxza2ksUi48L0F1dGhvcnNf
UHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkRlcmVqa28sUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0
aG9yc19QcmltYXJ5PlByenlieWxza2ksQS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PlVyYmFuZWssUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkt1c21pZXJj
enlrLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Lb3psdWssRS48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNhY2hlcixGLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+U2FuZGVycyxQLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+RGFuZ2VsLEouPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5IYWlzc2FndWVy
cmUsTS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PldhbGN6YWssRi48L0F1dGhv
cnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5PjIwMTAvOC8xPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRz
PkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5
d29yZHM+QW50aS1BcnJoeXRobWlhIEFnZW50czwvS2V5d29yZHM+PEtleXdvcmRzPkFycmh5dGht
aWFzLENhcmRpYWM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmlicmlsbGF0aW9uPC9LZXl3
b3Jkcz48S2V5d29yZHM+Q2FyZGlvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPkNhdGhldGVyIEFi
bGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Y29tcGxpY2F0aW9uczwvS2V5d29yZHM+PEtleXdv
cmRzPmRpYWdub3NpczwvS2V5d29yZHM+PEtleXdvcmRzPkRydWcgUmVzaXN0YW5jZTwvS2V5d29y
ZHM+PEtleXdvcmRzPmRydWcgdGhlcmFweTwvS2V5d29yZHM+PEtleXdvcmRzPkVjaG9jYXJkaW9n
cmFwaHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvcGh5c2lvbG9naWMgVGVjaG5pcXVlcyxD
YXJkaWFjPC9LZXl3b3Jkcz48S2V5d29yZHM+RXVyb3BlPC9LZXl3b3Jkcz48S2V5d29yZHM+RmVt
YWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+RmV0dXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5GbHVvcm9z
Y29weTwvS2V5d29yZHM+PEtleXdvcmRzPkdlc3RhdGlvbmFsIEFnZTwvS2V5d29yZHM+PEtleXdv
cmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPlByZWduYW5jeTwvS2V5d29yZHM+PEtleXdv
cmRzPlByZWduYW5jeSBDb21wbGljYXRpb25zLENhcmRpb3Zhc2N1bGFyPC9LZXl3b3Jkcz48S2V5
d29yZHM+UmFkaWF0aW9uIERvc2FnZTwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2sgQXNzZXNzbWVu
dDwvS2V5d29yZHM+PEtleXdvcmRzPlNldmVyaXR5IG9mIElsbG5lc3MgSW5kZXg8L0tleXdvcmRz
PjxLZXl3b3Jkcz5Tb3V0aCBBdXN0cmFsaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9L
ZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNh
cmRpYSxSZWNpcHJvY2F0aW5nPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsU3VwcmF2
ZW50cmljdWxhcjwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcGV1dGljIHVzZTwvS2V5d29yZHM+
PEtleXdvcmRzPlRpbWU8L0tleXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgRmFpbHVyZTwvS2V5
d29yZHM+PEtleXdvcmRzPlVsdHJhc29ub2dyYXBoeSxEb3BwbGVyPC9LZXl3b3Jkcz48S2V5d29y
ZHM+VWx0cmFzb25vZ3JhcGh5LFByZW5hdGFsPC9LZXl3b3Jkcz48S2V5d29yZHM+V29sZmYtUGFy
a2luc29uLVdoaXRlIFN5bmRyb21lPC9LZXl3b3Jkcz48S2V5d29yZHM+WW91bmcgQWR1bHQ8L0tl
eXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjg3NzwvU3Rh
cnRfUGFnZT48RW5kX1BhZ2U+ODgyPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5KIENhcmRpb3Zhc2Mg
RWxlY3Ryb3BoeXNpb2wuPC9QZXJpb2RpY2FsPjxWb2x1bWU+MjE8L1ZvbHVtZT48SXNzdWU+ODwv
SXNzdWU+PElTU05fSVNCTj4xNTQwLTgxNjc8L0lTU05fSVNCTj48TWlzY18zPkpDRTE3Mjc7MTAu
MTExMS9qLjE1NDAtODE2Ny4yMDEwLjAxNzI3Lng8L01pc2NfMz48QWRkcmVzcz5JbnN0aXR1dGUg
b2YgQ2FyZGlvbG9neSwgQWxwZWpza2EgNDIsIFdhcnNhdywgUG9sYW5kLiBsc3p1bW93c2tpQGlr
YXJkLnBsPC9BZGRyZXNzPjxXZWJfVVJMPlBNOjIwMTU4NTYzPC9XZWJfVVJMPjxaWl9Kb3VybmFs
RnVsbD48ZiBuYW1lPSJTeXN0ZW0iPkpvdXJuYWwgb2YgY2FyZGlvdmFzY3VsYXIgZWxlY3Ryb3Bo
eXNpb2xvZ3k8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48ZiBuYW1l
PSJTeXN0ZW0iPkogQ2FyZGlvdmFzYyBFbGVjdHJvcGh5c2lvbC48L2Y+PC9aWl9Kb3VybmFsU3Rk
QWJicmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVm
bWFuPm==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN6dW1vd3NraTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+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ADDIN EN.CITE.DATA (354)20158563Observational, multicenter report experience w/ ablation of SVT in pregnancy9 ptsPt w/ severe SVT refractory to medical therapy; ablation w/ low radiation exposureSuccessful ablation; adverse effectsAll pathways eliminated successfullyAll pts treated successfully, w/ either no radiation at all to very low dose.Pregnancy: Prophylactic Antiarrhythmic Drug TherapyWen Z1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldlbjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (41)9851958Prospective cohort study133AVRT (n=85) AVNRT (n=48)EP study to induce PSVT by PESExcluded atrial flutter, AF organic heart disease or other systemic diseases involving the autonomic function (e.g., diabetes), those who could not blow into an aneroid manometer to maintain a pressure of 35 mm Hg for 20 sec, and those w/ unstable hemodynamics during tachycardia.Termination of PSVTVagal maneuvers more effective in terminating AVRT than AVNRT (53 vs. 33%, p<0.05). AVNRT: vagal maneuvers terminated tachycardia in antegrade slow pathway (14%) or in retrograde fast pathway (19%). Baroreflex sensitivity was poorer but isoproterenol sensitivity test better in pts w/ AVNRT.Vagal maneuvers effective, more so for AVRT. Limited in that study conducted during EP study.Lydakis C 1999 ADDIN REFMGR.CITE <Refman><Cite><Author>Lydakis</Author><Year>1999</Year><RecNum>119</RecNum><IDText>Atenolol and fetal growth in pregnancies complicated by hypertension</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>119</Ref_ID><Title_Primary>Atenolol and fetal growth in pregnancies complicated by hypertension</Title_Primary><Authors_Primary>Lydakis,C.</Authors_Primary><Authors_Primary>Lip,G.Y.</Authors_Primary><Authors_Primary>Beevers,M.</Authors_Primary><Authors_Primary>Beevers,D.G.</Authors_Primary><Date_Primary>1999/6</Date_Primary><Keywords>Adult</Keywords><Keywords>adverse effects</Keywords><Keywords>Antihypertensive Agents</Keywords><Keywords>Atenolol</Keywords><Keywords>Cohort Studies</Keywords><Keywords>complications</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Embryonic and Fetal Development</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Hypertension</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Pregnancy</Keywords><Keywords>Pregnancy Complications,Cardiovascular</Keywords><Keywords>Pregnancy Outcome</Keywords><Keywords>Prevalence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>therapeutic use</Keywords><Reprint>Not in File</Reprint><Start_Page>541</Start_Page><End_Page>547</End_Page><Periodical>Am J Hypertens.</Periodical><Volume>12</Volume><Issue>6</Issue><ISSN_ISBN>0895-7061</ISSN_ISBN><Misc_3>S0895-7061(99)00031-X</Misc_3><Address>University Department of Medicine, City Hospital, Birmingham, United Kingdom</Address><Web_URL>PM:10371362</Web_URL><ZZ_JournalFull><f name="System">American journal of hypertension</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Hypertens.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(355)10371362Retrospective study on the effect of Atenolol and other drugs on fetal growth78Atenolol given to 78 pregnant women and compared to other parison of adverse effects to fetal growthIncreased risk of fetal growth retardationPossible increased risk of fetal growth retardation on atenolol compared to other drugs, risk related to duration of treatment.Von Dadelszen P 2000 ADDIN REFMGR.CITE <Refman><Cite><Author>von Dadelszen</Author><Year>2000</Year><RecNum>314</RecNum><IDText>Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>314</Ref_ID><Title_Primary>Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis</Title_Primary><Authors_Primary>von Dadelszen,P.</Authors_Primary><Authors_Primary>Ornstein,M.P.</Authors_Primary><Authors_Primary>Bull,S.B.</Authors_Primary><Authors_Primary>Logan,A.G.</Authors_Primary><Authors_Primary>Koren,G.</Authors_Primary><Authors_Primary>Magee,L.A.</Authors_Primary><Date_Primary>2000/1/8</Date_Primary><Keywords>analysis</Keywords><Keywords>Antihypertensive Agents</Keywords><Keywords>Birth Weight</Keywords><Keywords>blood</Keywords><Keywords>Blood Pressure</Keywords><Keywords>Canada</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Hypertension</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Infant,Small for Gestational Age</Keywords><Keywords>methods</Keywords><Keywords>Pregnancy</Keywords><Keywords>Pregnancy Complications,Cardiovascular</Keywords><Keywords>Pressure</Keywords><Keywords>Regression Analysis</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>87</Start_Page><End_Page>92</End_Page><Periodical>Lancet</Periodical><Volume>355</Volume><Issue>9198</Issue><ISSN_ISBN>0140-6736</ISSN_ISBN><Misc_3>S0140673698080490</Misc_3><Address>Department of Obstetrics and Gynaecology, University of Toronto, Canada</Address><Web_URL>PM:10675164</Web_URL><ZZ_JournalStdAbbrev><f name="System">Lancet</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(356)10675164Metanalysis of different drugs, mainly beta blockers, inpregnancy3773Meta analysis of different drugs for pregnancy induced HTN to try to determine if growth retardation is due to drugs or disease.The association of treatment-induced difference in mean arterial pressure with measures of fetoplacental growthRelationship was observed between fall in MAP and growth retardation, but was not related to drugs.Beta blockers mainly safe during pregnancy, growth retardation likely due to fall in BP.Bartalena2001 ADDIN REFMGR.CITE <Refman><Cite><Author>Bartalena</Author><Year>2001</Year><RecNum>117</RecNum><IDText>Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>117</Ref_ID><Title_Primary>Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment</Title_Primary><Authors_Primary>Bartalena,L.</Authors_Primary><Authors_Primary>Bogazzi,F.</Authors_Primary><Authors_Primary>Braverman,L.E.</Authors_Primary><Authors_Primary>Martino,E.</Authors_Primary><Date_Primary>2001/2</Date_Primary><Keywords>abnormalities</Keywords><Keywords>adverse effects</Keywords><Keywords>Amiodarone</Keywords><Keywords>Breast Feeding</Keywords><Keywords>chemically induced</Keywords><Keywords>complications</Keywords><Keywords>diagnosis</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Fetus</Keywords><Keywords>growth & development</Keywords><Keywords>Humans</Keywords><Keywords>Hypothyroidism</Keywords><Keywords>Infant</Keywords><Keywords>Infant,Newborn</Keywords><Keywords>Italy</Keywords><Keywords>Lactation</Keywords><Keywords>Maternal-Fetal Exchange</Keywords><Keywords>Nervous System</Keywords><Keywords>Pregnancy</Keywords><Keywords>Psychomotor Disorders</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>116</Start_Page><End_Page>130</End_Page><Periodical>J Endocrinol.Invest</Periodical><Volume>24</Volume><Issue>2</Issue><ISSN_ISBN>0391-4097</ISSN_ISBN><Address>University of Insubria, Varese, Italy</Address><Web_URL>PM:11263469</Web_URL><ZZ_JournalFull><f name="System">Journal of endocrinological investigation</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">J Endocrinol.Invest</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(357)11263469Review of case reports when amiodarone was given during pregnancy64Review of case reports when amiodarone was given. There were 64 identified and effect on babies was reported.Adverse effects documented on progeny of mothers who received amiodarone.Hypothyroidism reported in 17%, which most of the time was transient. Some developmental disabilities seen even in euthyroid.Maternal use of amiodarone can cause hypothyroidism in progeny and occasionally neurodevelopmental abnormalities. Qasqas SA 2004 ADDIN REFMGR.CITE <Refman><Cite><Author>Qasqas</Author><Year>2004</Year><RecNum>109</RecNum><IDText>Cardiovascular pharmacotherapeutic considerations during pregnancy and lactation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>109</Ref_ID><Title_Primary>Cardiovascular pharmacotherapeutic considerations during pregnancy and lactation</Title_Primary><Authors_Primary>Qasqas,S.A.</Authors_Primary><Authors_Primary>McPherson,C.</Authors_Primary><Authors_Primary>Frishman,W.H.</Authors_Primary><Authors_Primary>Elkayam,U.</Authors_Primary><Date_Primary>2004/7</Date_Primary><Keywords>Abnormalities,Drug-Induced</Keywords><Keywords>adverse effects</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Anticoagulants</Keywords><Keywords>blood supply</Keywords><Keywords>Breast Feeding</Keywords><Keywords>Cardiac Glycosides</Keywords><Keywords>Cardiovascular System</Keywords><Keywords>drug effects</Keywords><Keywords>drug therapy</Keywords><Keywords>Female</Keywords><Keywords>Fetus</Keywords><Keywords>Humans</Keywords><Keywords>Infant</Keywords><Keywords>Lactation</Keywords><Keywords>Maternal-Fetal Exchange</Keywords><Keywords>pharmacokinetics</Keywords><Keywords>Pregnancy</Keywords><Keywords>Prenatal Exposure Delayed Effects</Keywords><Keywords>prevention & control</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>201</Start_Page><End_Page>221</End_Page><Periodical>Cardiol Rev.</Periodical><Volume>12</Volume><Issue>4</Issue><ISSN_ISBN>1061-5377</ISSN_ISBN><Misc_3>10.1097/01.crd.0000102420.62200.e1;01.crd.0000102420.62200.e1</Misc_3><Address>Departments of Medicine, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, Missouri, USA</Address><Web_URL>PM:15191632</Web_URL><ZZ_JournalFull><f name="System">Cardiology in review</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Cardiol Rev.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(358)15191632Review article on all cardiovascular drugs in pregnancy.N/AThis is a review article. N/AAll drugs are describe in detail and references made to all case reports.This is a comprehensive compendium of all antiarrhythmic agents give during pregnancy.Jaeggi ET 2011PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphZWdnaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkphZWdnaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN EN.CITE.DATA (359) 21931080 Nonrandomized multicenter comparison of different drugs administered for transplacental therapy of fetal SVT159The authors reviewed 159 consecutive referrals w/ fetal SVT (n=114) and AF (n=45). Of these, 75 fetuses w/ SVT and 36 w/ AF were treated nonrandomly w/ transplacental flecainide (n=35), sotalol (n=52), or digoxin (n=24) as a first-line agent.Effectiveness of different drugs reported.Flecainide and digoxin were superior to sotalol for fetal SVT.This was a study for fetal SVT, but showed that flecainide sotalol and digoxin are well tolerated in pregnant women.SVT in the ElderlyChen SA 1995PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW48L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxSZWNO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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW48L0F1dGhvcj48WWVhcj4xOTk1PC9ZZWFyPjxSZWNO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 EN.CITE.DATA (360)7490388Observational66 pts w/ AVRT and AVNRT w/ initial sx onset after age 65 vs. 440 pts w/ sxs onset before age 30All pts underwent EP study and RFA;4 mm tip temperature control deflectable catheterCompare clinical characteristics in the older vs. younger grooupsOlder group: 32/66 had AVRT, 34/66 had AVNRTYounger group: 283/440 AVRT, 157/444 AVNRTSxs of syncope and cardioversion were similar between two age groups; older pts had more atrial and ventricular ectopic beats on Holter; dispersion of anterograde ERP was greater in older pts; Success rate was 97-98% in all groups; Recurrence was similar (6-7%; f/u duration was not stated in the paper); complications were significantly higher (13-14% in older pts than younger pts (1%) (for AVRT: 2 arterial thrombosis, 1 TIA, 1 DVT; for AVNRT: 1 DVT, 1 AV block)Greater dispersion of ERP and increased atrial and ventricular ectopic beats may explain the later onset of sxs in older pts.Chen SA1996PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW48L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNO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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW48L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (361)8540455Observational3966 consecutive EP study and 2593 ablation procedures Tertiary referral center in Taiwan, 1987 – 19944 mm tip temperature control deflectable catheterRisk factors associated w/ complicationsOverall complications, RFA vs. EP study, 3.1% vs. 1.1% (p 0.00002); Older (≥65 y) vs. younger, 2.2% vs. 0.5% (p 0.0002) for EP study and 6.1% vs. 2.0% for RFA. Older age and presence of systemic disease are independent predictors for plications included pericardial eff/usion, tamponade, AVB, vascular injury, systemic emboli)Data suggest older age is an independent risk for EP study and RFA. These data are somewhat out dated. Older pts had more co-morbidies and the presence of systemic diseases (co-morbidities) is an independent predictor of acute complications.Boulos M1998 ADDIN REFMGR.CITE <Refman><Cite><Author>Boulos</Author><Year>1998</Year><RecNum>315</RecNum><IDText>Age dependence of complete heart block complicating radiofrequency ablation of the atrioventricular nodal slow pathway</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>315</Ref_ID><Title_Primary>Age dependence of complete heart block complicating radiofrequency ablation of the atrioventricular nodal slow pathway</Title_Primary><Authors_Primary>Boulos,M.</Authors_Primary><Authors_Primary>Hoch,D.</Authors_Primary><Authors_Primary>Schecter,S.</Authors_Primary><Authors_Primary>Greenberg,S.</Authors_Primary><Authors_Primary>Levine,J.</Authors_Primary><Date_Primary>1998/8/1</Date_Primary><Keywords>adverse effects</Keywords><Keywords>Age Factors</Keywords><Keywords>Aged</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Electrocardiography</Keywords><Keywords>etiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart</Keywords><Keywords>Heart Block</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Postoperative Complications</Keywords><Keywords>Recurrence</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Risk</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Reprint>Not in File</Reprint><Start_Page>390</Start_Page><End_Page>391</End_Page><Periodical>Am J Cardiol</Periodical><Volume>82</Volume><Issue>3</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002-9149(98)00289-6</Misc_3><Address>Cardiac Arrhythmia and Pacemaker Center, St. Francis Hospital, Long Island, New York, USA</Address><Web_URL>PM:9708674</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(362)9708674Observational 271 consecutive ptsAVNRT from a single center undergoing RFA, 1991 – 1995.4 mm tip deflectable catheter were used to map and ablateSlow pathway ablationAcute success rate 98.1%, recurrence rate 4.1%; CHB 2.2%, 2% for pts <65 y of age, 8% in older pts; Older age is associated w/ higher risk of CHB.Data are historical.The focus was on AVB complicating slow pathway ablation; no other complications were reported.Kalusche1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbHVzY2hlPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbHVzY2hlPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48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ADDIN EN.CITE.DATA (9)9812187 Retrospective cohort study395 pts undergoing AVNRT RFA. 85 (22%) ≥65 y (mean 70 y). Consecutive pts from a single center in Germany, 1992 – 19979 pts were excluded due to more than one tachycardia inducible4 mm tip temperature controlled deflectable catheterClinical presentation and outcomes in young vs. elderly during AVNRT ablationSimilar to younger pts, elderly more often had organic heart disease (CAD w/ or w/o MI,19.3% vs. 2.6%; P<0.02), syncope or presyncope w/ AVNRT (43.2% vs. 29.8%; P<0.05). 17.5% vs. 6.5% (P<0.05) the fast pathway approach was chosen as the first therapy. The overall success rate (96.8% vs. 95.3%) and recurrence rate (5.8% vs. 4.9%) were similar in both pt groups.Details of complications not listed: “minor complications such as hematoma; severe complications such as need of a PM” (2 in older group, 1 in younger group); f/u 2-68 mo.Elderly pts have more severe sxs and more comorbid illnesses, but RFA safe. Zado2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlphZG88L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlphZG88L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (363)10676694 Prospective cohort study695 pts were divided into: ≥80 y (n=37), 60-79 (n=275), and <60 y (n=383)Ablation for SVT, VT (only 8% VT, 43% His ablation)Determine whether catheter ablation is safe and effective in pts >80 y.Overall success rate 95% (e groups (97% ≥80 y; 94% 60-79 y; 95%, <60 y). The overall complication rate for the entire group was 2.6%; no difference in complication rates among the groups (0%, ≥80 y; 2.2%, 60 to 79 y; 3.1%, <60 y)RFA safe in elderly. However ,only 37 pts were >80 y. Li YG2001PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48UmVjTnVt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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48UmVjTnVt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ADDIN EN.CITE.DATA (364)11133214Observational18 pts among 346 pts w/ prolong PR at baselineSlow pathway ablation in pts w/ AVNRT4 mm tip temperature control deflectable catheterLate occurrence of AVB after complete short pathway ablation in AVNRT18/346 pts w/ prolong PR before RFA, age 62±7; Holters were obtained before, 1 d, 1 wk, 1, 3, 6 mo after ablation. Incidence of delayed AVB occurred in 6/18 pts w/ preexisting PR prolongation; antepgrade ERP was longer in the study groupRisk of AVB is increased after short pathway ablation in pts w/ pre-existing PR prolongation. These data have not been confirmed in the contemporary era.Porter MJ2004PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBvcnRlcjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl
Y051bT4zMjQ8L1JlY051bT48SURUZXh0PkluZmx1ZW5jZSBvZiBhZ2UgYW5kIGdlbmRlciBvbiB0
aGUgbWVjaGFuaXNtIG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWE8L0lEVGV4dD48TURM
IFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD4z
MjQ8L1JlZl9JRD48VGl0bGVfUHJpbWFyeT5JbmZsdWVuY2Ugb2YgYWdlIGFuZCBnZW5kZXIgb24g
dGhlIG1lY2hhbmlzbSBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhPC9UaXRsZV9Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+UG9ydGVyLE0uSi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9y
c19QcmltYXJ5Pk1vcnRvbixKLkIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5E
ZW5tYW4sUi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkxpbixBLkMuPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5UaWVybmV5LFMuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5TYW50dWNjaSxQLkEuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5DYWksSi5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TWFkc2Vu
LE4uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5XaWxiZXIsRC5KLjwvQXV0aG9y
c19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAwNC8xMDwvRGF0ZV9QcmltYXJ5PjxLZXl3b3Jkcz5B
Y2NlbGVyYXRlZCBJZGlvdmVudHJpY3VsYXIgUmh5dGhtPC9LZXl3b3Jkcz48S2V5d29yZHM+QWRv
bGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+QWdl
IEZhY3RvcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5BZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+QWdl
ZCw4MCBhbmQgb3ZlcjwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlhbCBGaWJyaWxsYXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BdHJpYWwgRmx1dHRlcjwvS2V5d29yZHM+PEtleXdvcmRzPkNhdGhl
dGVyIEFibGF0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2hpbGQ8L0tleXdvcmRzPjxLZXl3b3Jk
cz5DaGlsZCxQcmVzY2hvb2w8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5IdW1hbnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29y
ZHM+bWV0aG9kczwvS2V5d29yZHM+PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5
d29yZHM+UGF0aWVudHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRob2xvZ3k8L0tleXdv
cmRzPjxLZXl3b3Jkcz5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmVz
ZWFyY2g8L0tleXdvcmRzPjxLZXl3b3Jkcz5TZXggRmFjdG9yczwvS2V5d29yZHM+PEtleXdvcmRz
PlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsQXRyaW92ZW50cmlj
dWxhciBOb2RhbCBSZWVudHJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsUGFyb3h5
c21hbDwvS2V5d29yZHM+PEtleXdvcmRzPnRoZXJhcHk8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBp
biBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjM5MzwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+Mzk2
PC9FbmRfUGFnZT48UGVyaW9kaWNhbD5IZWFydCBSaHl0aG08L1BlcmlvZGljYWw+PFZvbHVtZT4x
PC9Wb2x1bWU+PElzc3VlPjQ8L0lzc3VlPjxJU1NOX0lTQk4+MTU0Ny01MjcxPC9JU1NOX0lTQk4+
PE1pc2NfMz5TMTU0Ny01MjcxKDA0KTAwMjg3LTU7MTAuMTAxNi9qLmhydGhtLjIwMDQuMDUuMDA3
PC9NaXNjXzM+PEFkZHJlc3M+TG95b2xhIENhcmRpb3Zhc2N1bGFyIEluc3RpdHV0ZSwgTG95b2xh
IFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIE1heXdvb2QsIElsbGlub2lzIDYwMTUzLCBVU0E8
L0FkZHJlc3M+PFdlYl9VUkw+UE06MTU4NTExODk8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxm
IG5hbWU9IlN5c3RlbSI+SGVhcnQgcmh5dGhtIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhl
IEhlYXJ0IFJoeXRobSBTb2NpZXR5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRB
YmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5IZWFydCBSaHl0aG08L2Y+PC9aWl9Kb3VybmFsU3RkQWJi
cmV2PjxaWl9Xb3JrZm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFu
PgB=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBvcnRlcjwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (365)15851189Observational 1754 consecutive pts, 1856 PSVT from a single center 1991-2003PSVT undergoing RFA; exclude IAST, flutter and fibrillation, age <5Mapping and ablation techniques were not described. Age and gender correlation to PSVTMean age 49±19 (5-96), women 62%; AVNRT 1042 (56%), AVRT 500 (27%), AT 315 (17%); AVRT decreases w/ age in both genders; AVNRT and AT increased w/ older age; majority (54.6%) of AVRT were men; majority of AVNRT and AT were women; In women, 63% had AVNRT, 20% AVRT and 17% AT; in men, 45% AVNRT, 39% AVRT, 17% ATSVT is age and gender dependent in this single center study among pts referred for RFA. It is unknown whether this reflects the epidemiology in the general population due to the evolution of ablation from 1990 – current and whether referral bias, specifically related to age.This is an age and gender dependent mechanism study; not an outcome studyRostock 2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvc3RvY2s8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlJvc3RvY2s8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (366)15946358 Retrospective cohort study<75 y (n=508) and pts ≥75 y (n=70)All pts w/ symptomatic AVNRT referred for slow-pathway ablation Determine whether catheter ablation is safe and effective in pts ≥75 y.Preexisting prolonged PR interval was present in 3.3 vs. 37% in pts <75 vs. older, p<0.0001). Following successful slow-pathway ablation, no induction of an AV block was observed in >75 y group. No recurrences occurred pts ≥75 y.Slow-pathway ablation in elderly pts effective and safe and should be considered as first line therapy in this pt population. Challenges evidence that preexisting PR prolongation found to be associated w/ a higher risk of developing a delayed high-degree AV block.Kihel J2006PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpaGVsPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPktpaGVsPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (367)16687422Observational, case control42 pts ≥75 y vs. 234 pts <75 yConsecutive pts w/ AVNRT from a single center in France, 1997 – 2004. 4 mm tip deflectable catheters were used for mapping and ablationDetermine whether catheter ablation is safe and effective comparing older vs. younger ptsSuccess rate 100% in the elderly vs. 99.6% in the younger pts; 1 minor complication of groin hematoma occurred in older pts (2.4%), 4 (1.7%) in younger pts including one PE, one pericardial effusion, 2 hematoma. Recurrent was 0 in older pts, 3.4% in the younger pts (p 0.5)F/u duration was 28 mo and 35 mo in older and younger groups, respectively.Catheter ablation for AVNRT is reasonable w/ high success rate and low complication rate. The data are more contemporary.No difference between older and younger groups.Dagres N 2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhZ3JlczwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRhZ3JlczwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl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ADDIN EN.CITE.DATA (368)17434888Observational131 consecutive pts ≥80 y old undergoing ablation Consecutive pts from 3 centers: Greece, Germany and Switzerland, 1998 – 2004“Temperature guided” approach Determine pt characteristics and ablation outcomesFlutter most common (54%), AVNRT 22%, AF 18%. 52% had SHD. AVN ablation was performed in pts w/ AF. Overall success rate was 97% w/ one pts had a CVA after isthmus ablation for flutter. Minor complications such as hematoma occurred in 3.1% of study populationIn selected elderly pts, ablation is highly successful for flutter, AVNRT and AVN ablation. More than half of the elderly pts have SHD when undergoing RFA. The consistent theme w/ other contemporary studies is that elderly have more co-morbid conditions but the overall ablation outcomes are highly successful w/ acceptable low complications. None of these studies are randomized studies; selection bias cannot be excluded.Haghjoo M 2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhZ2hqb288L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhhZ2hqb288L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (369)17069836Observational case control268 consecutive pts underwent RFA for AVNRT; 2001 - 2005Dichotomized at 65 y of ageAblation outcomes156/112 : younger/older; CL longer in older pts; success rate, complications, the recurrences were similar between older and younger ptsNo significant differences in outcomes between the two age groups dichotomized at 65 y of agePedrinazzi C 2007PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlZHJpbmF6emk8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlBlZHJpbmF6emk8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy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ADDIN EN.CITE.DATA (370)17823861ObservationTotal of 605 ptsConsecutive pts undergoing RFA for all arrhythmias in a single center in Italy, 2000-20054 mm tip temperature control deflectable catheterRFA outcomesOlder pts had more co-morbidities; 69% <70 y of age, 24% 70-79 y, 7% ≥80 y; complications were similar 1.2 vs. 1.4 vs. 2%; Complications included pneumothorax, pericardial eff/usion, and hematoma; success rates were similar 92 vs. 88 vs. 88%; recurrence was followed up to 12 mo; AT and flutter had higher recurrence rate than AVNRT or AVRTOutcomes of RFA for SVT and VT were similar in younger and older pt groups.No major complicationsYangni N’Da’ O2008 ADDIN REFMGR.CITE <Refman><Cite><Author>Yangni</Author><Year>2008</Year><RecNum>327</RecNum><IDText>Clinical characteristics and management of paroxysmal junctional tachycardia in the elderly</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>327</Ref_ID><Title_Primary>Clinical characteristics and management of paroxysmal junctional tachycardia in the elderly</Title_Primary><Authors_Primary>Yangni,N'Da' O.</Authors_Primary><Authors_Primary>Brembilla-Perrot,B.</Authors_Primary><Date_Primary>2008/3</Date_Primary><Keywords>Aged</Keywords><Keywords>Aged,80 and over</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Comorbidity</Keywords><Keywords>complications</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Heart Rate</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>physiology</Keywords><Keywords>physiopathology</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Ectopic Junctional</Keywords><Keywords>Tachycardia,Paroxysmal</Keywords><Keywords>therapy</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>143</Start_Page><End_Page>148</End_Page><Periodical>Arch.Cardiovasc Dis</Periodical><Volume>101</Volume><Issue>3</Issue><ISSN_ISBN>1875-2136</ISSN_ISBN><Misc_3>S1875-2136(08)71795-9</Misc_3><Address>Service de cardiologie, Centre hospitalier universitaire de Brabois, Vandoeuvre-les-Nancy</Address><Web_URL>PM:18477940</Web_URL><ZZ_JournalFull><f name="System">Archives of cardiovascular diseases</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Arch.Cardiovasc Dis</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(371)18477940Observational141/816 (17%) elderly >70 y of age admitted for recurrent SVTParoxysmal junctional tachycardia actually included AVNRT and AVRTTemperature controlled catheterClinical outcomes after RFAIn the acute setting: Cardiac decompenstation 10, syncope 26, ACS 14, vascular event 5; typical AVNRT 73%; atypical AVNRT more common in older pts than in younger pts (15% vs. 4%); ablation was performed in 79% of the older pts vs. 57% in the younger pts; complications more common 7% vs. 2.5% in older pts; more AF induced during study (19% vs. 5%)Older pts have more severe sxs associated w/ SVT at baseline; Atypical AVNRT is more common in older pts. Complications are higher in older pts.Very difficult paper to understand; did not specifically, or clearly, state the types of complications.Hoffman BA2011PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvZmZtYW5uPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvZmZtYW5uPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48
UmVjTnVtPjMxOTwvUmVjTnVtPjxJRFRleHQ+QWJsYXRpb24gb2YgYXRyaW92ZW50cmljdWxhciBu
b2RhbCByZWVudHJhbnQgdGFjaHljYXJkaWEgaW4gdGhlIGVsZGVybHk6IHJlc3VsdHMgZnJvbSB0
aGUgR2VybWFuIEFibGF0aW9uIFJlZ2lzdHJ5PC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0iSm91cm5h
bCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+MzE5PC9SZWZfSUQ+PFRpdGxl
X1ByaW1hcnk+QWJsYXRpb24gb2YgYXRyaW92ZW50cmljdWxhciBub2RhbCByZWVudHJhbnQgdGFj
aHljYXJkaWEgaW4gdGhlIGVsZGVybHk6IHJlc3VsdHMgZnJvbSB0aGUgR2VybWFuIEFibGF0aW9u
IFJlZ2lzdHJ5PC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+SG9mZm1hbm4sQi5BLjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+QnJhY2htYW5uLEouPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5BbmRyZXNlbixELjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+RWNrYXJkdCxMLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
SG9mZm1hbm4sRS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkt1Y2ssSy5ILjwv
QXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2NodW1hY2hlcixCLjwvQXV0aG9yc19Q
cmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U3BpdHplcixTLkcuPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5TY2hpcmRld2FobixQLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+VGViYmVuam9oYW5ucyxKLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+
SG9yYWNrLE0uPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TZW5nZXMsSi48L0F1
dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNhbHVraGUsVC5WLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+Um9zdG9jayxULjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3Jz
X1ByaW1hcnk+V2lsbGVtcyxTLjwvQXV0aG9yc19QcmltYXJ5PjxEYXRlX1ByaW1hcnk+MjAxMS83
PC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+QWdlIERp
c3RyaWJ1dGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkFnZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5B
Z2VkLDgwIGFuZCBvdmVyPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tl
eXdvcmRzPjxLZXl3b3Jkcz5Dcnlvc3VyZ2VyeTwvS2V5d29yZHM+PEtleXdvcmRzPkRpc2Vhc2U8
L0tleXdvcmRzPjxLZXl3b3Jkcz5kcnVnIHRoZXJhcHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5lcGlk
ZW1pb2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5G
b2xsb3ctVXAgU3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPkdlcm1hbnk8L0tleXdvcmRzPjxL
ZXl3b3Jkcz5IZWFydDwvS2V5d29yZHM+PEtleXdvcmRzPkhlYXJ0IENvbmR1Y3Rpb24gU3lzdGVt
PC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFu
czwvS2V5d29yZHM+PEtleXdvcmRzPkluY2lkZW5jZTwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8
L0tleXdvcmRzPjxLZXl3b3Jkcz5tZXRob2RzPC9LZXl3b3Jkcz48S2V5d29yZHM+TWlkZGxlIEFn
ZWQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYXRpZW50czwvS2V5d29yZHM+PEtleXdvcmRzPnBoeXNp
b2xvZ3k8L0tleXdvcmRzPjxLZXl3b3Jkcz5waHlzaW9wYXRob2xvZ3k8L0tleXdvcmRzPjxLZXl3
b3Jkcz5QcmV2YWxlbmNlPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1ZGllczwv
S2V5d29yZHM+PEtleXdvcmRzPlJlY3VycmVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5SZWdpc3Ry
aWVzPC9LZXl3b3Jkcz48S2V5d29yZHM+UmlzazwvS2V5d29yZHM+PEtleXdvcmRzPlNhZmV0eTwv
S2V5d29yZHM+PEtleXdvcmRzPnN0YXRpc3RpY3MgJmFtcDsgbnVtZXJpY2FsIGRhdGE8L0tleXdv
cmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWE8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxBdHJpb3ZlbnRyaWN1bGFyIE5vZGFsIFJlZW50
cnk8L0tleXdvcmRzPjxLZXl3b3Jkcz50aGVyYXB5PC9LZXl3b3Jkcz48S2V5d29yZHM+VHJlYXRt
ZW50IE91dGNvbWU8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFy
dF9QYWdlPjk4MTwvU3RhcnRfUGFnZT48RW5kX1BhZ2U+OTg3PC9FbmRfUGFnZT48UGVyaW9kaWNh
bD5IZWFydCBSaHl0aG08L1BlcmlvZGljYWw+PFZvbHVtZT44PC9Wb2x1bWU+PElzc3VlPjc8L0lz
c3VlPjxJU1NOX0lTQk4+MTU1Ni0zODcxPC9JU1NOX0lTQk4+PE1pc2NfMz5TMTU0Ny01MjcxKDEx
KTAwMTQ1LTc7MTAuMTAxNi9qLmhydGhtLjIwMTEuMDIuMDA4PC9NaXNjXzM+PEFkZHJlc3M+VW5p
dmVyc2l0eSBIZWFydCBDZW50ZXIsIERlcGFydG1lbnQgb2YgQ2FyZGlvbG9neS9FbGVjdHJvcGh5
c2lvbG9neSwgSGFtYnVyZywgR2VybWFueS4gYi5ob2ZmbWFubkB1a2UuZGU8L0FkZHJlc3M+PFdl
Yl9VUkw+UE06MjEzMTU4MzQ8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3Rl
bSI+SGVhcnQgcmh5dGhtIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEhlYXJ0IFJoeXRo
bSBTb2NpZXR5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFt
ZT0iU3lzdGVtIj5IZWFydCBSaHl0aG08L2Y+PC9aWl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3Jr
Zm9ybUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPgB=
ADDIN EN.CITE.DATA (372)21315834German registry; 48 trial centers in Germany3234 consecutive pts undergoing AVNRT ablation from 3/2007 to 5/2010AVNRT pts: >50 yGroup 1, n=1,268 [39.2%]; median age 40 y (95% CI: 30.0–45.0 y), 74.1% women, Group 2 50–75 y old(n=1,707 [52.8%]; 63.0 y [95% CI: 58.0–69.0] y, 63.0%women)Group 3 >75 y old (n =259 [8.0%]; 79.0 [95% CI: 77.0–82.0] y, 50.6% women).Acute and long term success rate, complications and recurrenceNo differences were observed among the three groups w/ regard to primary CA success rate (98.7% vs. 98.8% vs. 98.5%; P=0.92)Hemodynamically stable pericardial eff/usion occurred in five group 2 (0.3%) and two group 3 (0.8%) ptsbut in none of the group 1 (P=0.05) ptsAV block requiring permanent pacemaker implantation occurredin two pts in group 1 (0.2%) and six pts in group 2(0.4%) but none in group 3 (P= 0.41)During a median f/u of 511 d, recurrence rate was 5.7% in all ptsCatheter ablation for AVNRT is highly effective and safe and does not pose an increased risk for complete AV block in pts over 75 y of age, despite a higher prevalence of structural heartdisease.Ghali WA2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Ghali</Author><Year>2005</Year><RecNum>657</RecNum><IDText>Atrial flutter and the risk of thromboembolism: a systematic review and meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>657</Ref_ID><Title_Primary>Atrial flutter and the risk of thromboembolism: a systematic review and meta-analysis</Title_Primary><Authors_Primary>Ghali,W.A.</Authors_Primary><Authors_Primary>Wasil,B.I.</Authors_Primary><Authors_Primary>Brant,R.</Authors_Primary><Authors_Primary>Exner,D.V.</Authors_Primary><Authors_Primary>Cornuz,J.</Authors_Primary><Date_Primary>2005/2</Date_Primary><Keywords>analysis</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Canada</Keywords><Keywords>complications</Keywords><Keywords>Echocardiography</Keywords><Keywords>Electric Countershock</Keywords><Keywords>etiology</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Patients</Keywords><Keywords>Prognosis</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>Risk Factors</Keywords><Keywords>Thromboembolism</Keywords><Reprint>Not in File</Reprint><Start_Page>101</Start_Page><End_Page>107</End_Page><Periodical>Am J Med</Periodical><Volume>118</Volume><Issue>2</Issue><ISSN_ISBN>0002-9343</ISSN_ISBN><Misc_3>S0002-9343(04)00687-4;10.1016/j.amjmed.2004.06.048</Misc_3><Address>Department of Medicine, University of Calgary, Alberta, Canada. wghali@ucalgary.ca</Address><Web_URL>PM:15694889</Web_URL><ZZ_JournalFull><f name="System">The American journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Med</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(222)Systematic review and meta-analysis of observational studies that investigated risk of thromboembolism associated with atrial flutter.The meta analysis included 13 studies on embolic risk around time of cardioversion that included 1546 patients. For chronic risk, there were 14 studies involving 17,691 patients.MEDLINE, EMBASE, bibliographies, and consultation with clinical experts were used to identify studies that report the risk of thromboembolism associated with attempted cardioversion and longer-term risk in patients with atrial flutter.Risk of thromboembolism associated with atrial flutter around time of cardioversion or over the long term in chronic atrial flutter.Around the time of cardioversion, the risk of thromboembolic events ranged from 0% to 7.3% depending of clinical factors.Lower event rates were observed in patients taking anticoagulants.The long term risk rate of thromboembolism was approximately 3% with sustained atrial flutter.The findings of this systematic review strongly suggest that atrial flutter does indeed impart a risk of thromboembolism. AA indicates antiarrhythmic; AARCC, Allicance for Adult Research in Congential Cardiology; AC, atrioventricular connections; ACE I/D, angiotensin converting enzyme insertion/deletion; ACHD, adult congenital heart disease; ACS, acute coronary syndrome; ADT, antidromic tachycardia; AF, atrial fibrillation; AICD, automatic implantable cardioverter defibrillator; AP, accessory pathway; APERP, accessory pathway effective refractory period; ART, atrioventricular tachycardia; ASD, atrioventricular septal defect; AT, atrial tachycardia; ATP, antitachycardia pacing; AVB, atrioventricular block; AVN, atrioventricular node; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; AVSD, atrioventricular septal defects; BMI, body mass index; bpm, beats per min; BP, blood pressure; BSA, body surface area; CAD, coronary artery disease; cc-TGA, congenitally corrected transposition of the great arteries; CHD, congenital heart disease; CHF, congestive heart failure; CK-MB, creatinine kinase myocardial enzyme; CL, cycle length; CONCOR, Interuniversity Cardiology Institute of the Netherlands and the Netherlands Heart Foundation; CPB, cardiopulmonary bypass; CTI, cavotricuspid isthmus; CVA, cerebral vascular accident; DCCV, direct current cardioversion; DOVR, double outlet right ventricle; DVT, deep vein thrombosis; dx, diagnosis; EAT, ectopic atrial tachycardia; ECG, electrocardiogram; ECMO, extracorporeal membrane oxygenation; ED, emergency department; EP, electrophysiological; ERP, effective refractory period; f/u, follow up; HF, heart failure; h/o, history of; HR, heart rate; HTN, hypertension; IART, intraatrial reentrant tachycardia; IAST, inappropriate sinus tachycardia; ICD, implantable cardioverter defibrillator; ICU, intensive care unit; intraop, intraoperative; IV, intravenous; JET, junctional ectopic tachycardia; LA, left atrium; LFW, left free wall; LOS, length of stay; LVEF, left ventricular ejection fraction; MAP, mean arterial pressure; MAT, multifocal atrial tachycardia; MI, myocardial infarction; MRI, magnetic resonance imaging; NOS, nitric oxide synthase; NS, non-significant; NSVT, nonsustained ventricular tachycardia; OHT, orthotopic herat transplant; OR, odds ratio; ORT, orthodromic tachycardia; PES, programmed electrical stimulation; PLE, protein-losing enteropathy; postop, postoperative; POTS, postural tachycardia syndrome; preop, preoperative; PSVT, paroxysmal supraventricular tachycardia; pt, patient; QOL, quality of life; RA, right atrium; RACHS, risk adjustment for congenital heart surgery; RF, radiofrequency; RFA, radiofrequency ablation; RFCA, radiofrequency catheter ablation; RFW, right free wall; RV, right ventricular; RVOT, right ventricular outflow tract; rx, therapy; SHD, structural heart disease; s/p, status post; SR, sinus rhythm; SVA, supraventricular arrhythmia; SVT, supraventricular tachycardia; sx, symptom; TCPC, total cavopulmonary connection; TEP, transesophageal pacing; TGA, transposition of the great arteries; TIA, transischemic attack; TOF, tetralogy of Fallot; TSH, thyroid stimulating hormone; TV, tricuspid valve; UVH, univentricular heart; VA, ventriculoatrial; VF, ventricular fibrillation; VSD, ventricular septal defect; VT, ventricular tachycardia; w/, with; w/o, without; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 21. Randomized Trials Comparing Special Populations – Section 9 Study Name, Author, YearAim of StudyStudy Type (Size, N)Study Intervention Group (n)Study Comparator Group (n)Pt PopulationEndpointsP Values, OR: HR: RR: & 95% CI:Summary/ConclusionsInclusion CriteriaExclusion CriteriaPrimary Endpoint (efficacy) and ResultsSafety Endpoint and ResultsSecondary Endpoint and ResultsSaul JP 2005PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhdWw8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhdWw8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (373)16316969IV amiodarone efficacy/safetyMulticenter randomized double-blind (N=61)Ages <16 y, median 1.6 y. SVT 26, JET 31. 71% SHD. Dosages: low 1 mg/kg, medium 5 mg/kg, high 10 mg/kg, plus 47 h maintenance. 30 d f/u.N/AAges <16 y, median 1.6 y, SVT 26, JET 31. 71% SHD. Amidarone use <3 mo, drug intereaction w/ amiodarone, imminent death, intentional hypothermia to <35 degrees CEndpoint: time to success. Success low 47%, medium 80%, high 73%.Adverse events 87%, 5 deaths, 2 related to drug: profound hypotension medium and high dose.N/AMedium or high dose effective 2.1-2.6 h.Efficacy JET 67-83%. SVT 33-89%.Lim SH2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051
bT4yPC9SZWNOdW0+PElEVGV4dD5TbG93IGluZnVzaW9uIG9mIGNhbGNpdW0gY2hhbm5lbCBibG9j
a2VycyBjb21wYXJlZCB3aXRoIGludHJhdmVub3VzIGFkZW5vc2luZSBpbiB0aGUgZW1lcmdlbmN5
IHRyZWF0bWVudCBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhPC9JRFRleHQ+PE1ETCBS
ZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+Mjwv
UmVmX0lEPjxUaXRsZV9QcmltYXJ5PlNsb3cgaW5mdXNpb24gb2YgY2FsY2l1bSBjaGFubmVsIGJs
b2NrZXJzIGNvbXBhcmVkIHdpdGggaW50cmF2ZW5vdXMgYWRlbm9zaW5lIGluIHRoZSBlbWVyZ2Vu
Y3kgdHJlYXRtZW50IG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWE8L1RpdGxlX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5MaW0sUy5ILjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+QW5hbnRoYXJhbWFuLFYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5U
ZW8sVy5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hhbixZLkguPC9BdXRo
b3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA5LzU8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+
QWRlbm9zaW5lPC9LZXl3b3Jkcz48S2V5d29yZHM+YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl
PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5
dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+Qmxvb2QgUHJlc3N1cmU8L0tleXdvcmRz
PjxLZXl3b3Jkcz5DYWxjaXVtIENoYW5uZWwgQmxvY2tlcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5E
aWx0aWF6ZW08L0tleXdvcmRzPjxLZXl3b3Jkcz5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCxE
cnVnPC9LZXl3b3Jkcz48S2V5d29yZHM+RHJ1ZyBBZG1pbmlzdHJhdGlvbiBTY2hlZHVsZTwvS2V5
d29yZHM+PEtleXdvcmRzPmRydWcgZWZmZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhl
cmFweTwvS2V5d29yZHM+PEtleXdvcmRzPkVtZXJnZW5jeSBNZWRpY2FsIFNlcnZpY2VzPC9LZXl3
b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5
d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZnVzaW9ucyxJbnRy
YXZlbm91czwvS2V5d29yZHM+PEtleXdvcmRzPkluamVjdGlvbnMsSW50cmF2ZW5vdXM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+
PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1
ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFN1cHJhdmVudHJpY3VsYXI8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPlZl
cmFwYW1pbDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1Bh
Z2U+NTIzPC9TdGFydF9QYWdlPjxFbmRfUGFnZT41Mjg8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPlJl
c3VzY2l0YXRpb248L1BlcmlvZGljYWw+PFZvbHVtZT44MDwvVm9sdW1lPjxJc3N1ZT41PC9Jc3N1
ZT48SVNTTl9JU0JOPjAzMDAtOTU3MjwvSVNTTl9JU0JOPjxNaXNjXzM+UzAzMDAtOTU3MigwOSkw
MDA1Ny00OzEwLjEwMTYvai5yZXN1c2NpdGF0aW9uLjIwMDkuMDEuMDE3PC9NaXNjXzM+PEFkZHJl
c3M+RGVwYXJ0bWVudCBvZiBFbWVyZ2VuY3kgTWVkaWNpbmUsIFNpbmdhcG9yZSBHZW5lcmFsIEhv
c3BpdGFsLCBPdXRyYW0gUm9hZCwgU2luZ2Fwb3JlIDE2OTYwOCwgU2luZ2Fwb3JlPC9BZGRyZXNz
PjxXZWJfVVJMPlBNOjE5MjYxMzY3PC9XZWJfVVJMPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5h
bWU9IlN5c3RlbSI+UmVzdXNjaXRhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dv
cmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN EN.CITE.DATA (38)19261367Compare efficacy of bolus adenosine vs. slow calcium channel blockers in ED rx SVTProspective randomized trial (N=206). Mean ages 48.3±18.6 y.104 pts; adenosine 6 mg followed by 12 mg given as needed. Stopped w/ SVT conversion102 pts infusion verapamil 1 mg/min to max 20 mg, or dilitazem 2.5 mg/min to max 50 mg. Stopped w/ SVT conversion.Pts ≥10 y in ED w/ narrow QRS tachycardia, ECG dx SVT, not converting w/ vagal maneuvers.N/AConversion to SR: calcium channel blockers 98% vs. adenosine 86.5% (RR: 1/13; p= 0.002)N/ADrop in BP more common in calcium blockers group, mean SBP ↓13-7 mm Hg vs. no change w/ adenosine.N/ACalcium channel blockers effective and safe alternative to adenosine for conversion SVT; implications for cost. Manrique AM 2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hbnJpcXVlPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1hbnJpcXVlPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (374)19819469Assess magnesium sulfate supplementation during CPB on risk of JETRandomized, double-blind, controlled trial (N=99)2/05-8/06, pts <17 y undergoing CPB repair CHD randomized to receive MgSO4 during rewarmingPlacebo: 3 groups: Mg 25 mg/kg, 50 mg/kg or placebo.Pts from birth-17 y w/ elective cardiac surgery.Pts with Mg supplements for malnutrition, sepsis, pancreatitis, neonates.Total incidence JET 7.0%.JET incidences: Placebo 31%, low Mg 10%; higher Mg 0%. N/AN/AYounger age <1 mo, complex CHD Aristotle score ≥4, prior CHF correlated w/ JET. MgSO4 reduced incidence of postop JETSanatani S2012PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbmF0YW5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNhbmF0YW5pPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE.DATA (375)22962431Compare digoxin vs. propranolol for control of infant SVTMulticenter randomized double-blind (N=61)Digoxin (27)Propranolol (34)Infants <4 mo w/ SVT, AVRT or AVNRT.Excluding manifest WPW.Recurrent SVT. 27 digoxin, 34 propranolol SVT recurred 19% digoxin, 31% propranolol (p=0.25, NS). Recurrence free status 79% digoxin, 67% propranolol, NS.No deaths, no serious adverse events.Time to recurrence, adverse events. No first recurrence after 10 d.N/ANo difference between digoxin and propranolol in preventing recurrent SVT. As recurrences did not occur >110 d, may not need prolonged rx. AVNRT indicates atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; BP, blood pressure; CHD, congenital heart disease; CHF, congestive heart failure; CPB, cardiopulmonary bypass; dx, diagnosis; ECG, echocardiogram; ED, emergency department; IV, intravenous; JET, junctional ectopic tachycardia; N/A, not applicable; NS, non-significant; pt, patient; rx, therapy; SBP, systolic blood pressure; SHD, structural heart disease; SR, sinush rhythm; SVT, supraventricular tachycardia; w/, with; and WPW, Wolff-Parkinson-White syndrome. Data Supplement 22. Nonrandomized Trials, Observational Studies, and/or Registries of Quality-of-Life Considerations – Section 10StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsLau CP1995 ADDIN REFMGR.CITE <Refman><Cite><Author>Lau</Author><Year>1995</Year><RecNum>351</RecNum><IDText>The effects of radiofrequency ablation versus medical therapy on the quality-of-life and exercise capacity in patients with accessory pathway-mediated supraventricular tachycardia: a treatment comparison study</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>351</Ref_ID><Title_Primary>The effects of radiofrequency ablation versus medical therapy on the quality-of-life and exercise capacity in patients with accessory pathway-mediated supraventricular tachycardia: a treatment comparison study</Title_Primary><Authors_Primary>Lau,C.P.</Authors_Primary><Authors_Primary>Tai,Y.T.</Authors_Primary><Authors_Primary>Lee,P.W.</Authors_Primary><Date_Primary>1995/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Cardiac Pacing,Artificial</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Exercise</Keywords><Keywords>Exercise Test</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Research</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapeutic use</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>424</Start_Page><End_Page>432</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>18</Volume><Issue>3 Pt 1</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Address>Department of Medicine, University of Hong Kong, Queen Mary Hospital</Address><Web_URL>PM:7770362</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(376)7770362 QOL and exercise capacity in pts w/ PSVT due to AP treated medically vs. ablationN=55Random allocation to ablation vs. medical therapyPts w/ PSVT (including WPW) on stable medications for 3 moRandomly selected for ablation or continuing medical therapyQOL questionnaire and ETT performed at baseline and every 3 mo for 1 y Assessed PSVT frequency/duration of episodes; hemodynamic disturbance, presence of preexcited AF46 pts selected for ablation and 9 for medical therapy36/46 successfully ablated, and they improved in QOL at 3 mo post ablation (total scores on General Health Questionnaire, Somatic Symptoms Inventory and Sickness Impact Profile) P<0.01for all 3Improvements held at 1 yExercise capacity increased from 13.1±5.5 to 14.9 ±4.5 min at 3 mo after successful ablation (p<0.002) (due mostly to suppressing exercised induced PSVT).Medical group or those w/ unsuccessful ablation had no change in QOL or exercise capacityWhile pts randomly assigned to ablation vs. medical therapy, only 9 pts allocated to medical therapyPopulation – WPW, not other forms of PSVTBubien RS1996 ADDIN REFMGR.CITE <Refman><Cite><Author>Bubien</Author><Year>1996</Year><RecNum>346</RecNum><IDText>Effect of radiofrequency catheter ablation on health-related quality of life and activities of daily living in patients with recurrent arrhythmias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>346</Ref_ID><Title_Primary>Effect of radiofrequency catheter ablation on health-related quality of life and activities of daily living in patients with recurrent arrhythmias</Title_Primary><Authors_Primary>Bubien,R.S.</Authors_Primary><Authors_Primary>Knotts-Dolson,S.M.</Authors_Primary><Authors_Primary>Plumb,V.J.</Authors_Primary><Authors_Primary>Kay,G.N.</Authors_Primary><Date_Primary>1996/10/1</Date_Primary><Keywords>Activities of Daily Living</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>Arrhythmias,Cardiac</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Emergencies</Keywords><Keywords>Female</Keywords><Keywords>Health Status</Keywords><Keywords>Heart Diseases</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Recurrence</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>1585</Start_Page><End_Page>1591</End_Page><Periodical>Circulation</Periodical><Volume>94</Volume><Issue>7</Issue><ISSN_ISBN>0009-7322</ISSN_ISBN><Address>Department of Medicine, University of Alabama at Birmingham 35294, USA</Address><Web_URL>PM:8840848</Web_URL><ZZ_JournalStdAbbrev><f name="System">Circulation</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(377)8840848 Prospective cohort study, QOL of PSVT188AVNRT (n=59)AVRT (n=46)AF s/p AVJ ablation (n=22)Atrial flutter/AT (n=22)VT (n=10)QOL before, compared w/ 1 and 6 mo after RFA using SF-36 and disease-specific sx checklist—Frequency and Severity ScaleRFA associated w/ significant improvement in QOL sustained over 6 mo (p<0.005).RFA followed by improved performance of ADLs and a marked decrease in number of visits to physicians and emergency rooms in the 6 mo after RFA compared w/ 6 mo before.Pt's perception of impact of arrhythmias on health improved after ablation, maintained between 1 and 6 mo after ablation.90% of pts indicated that heart rhythm problems influenced health perception at baseline, and declined to 59% at 1 mo and 58% at 6 mo.N/AOverall demonstrates benefit of RFA on variety of arrhythmias. Tried to minimize response bias w/ anonymous mail surveys, self-reporting methods may be confounded by under-reporting of undesirable characteristics and over-reporting of socially desirable behaviors.*Bathina MN1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdGhpbmE8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdGhpbmE8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (378)9732885Prospective comparison of the impact of QOL and CE between RFA and pharmacologic therapy for PSVT79 w/ newly-documented PSVT Average number of drugs 1.35/pt(CCB, BB, most common)Exclusions: drug-refractory pts, prior treatment, AF, atrial flutter, preexcitationSF-36 used to measure QOL after 12-mo f/uRFA vs. medicationBodily pain:63±24 vs. 81±20p<0.005General health:69±21 vs. 79±21p<0.05Vitality:55±21 vs. 66±22p<0.05Role emotion:78±36 vs. 94±17p<0.05Ablation resulted in complete amelioration of sxs in 33% vs. 74%. First study to prospectively evaluate QOL and resource utilization between RFA vs. medical therapy.Both effective, but RFA improves QOL to a greater extent.Larson msec1999 ADDIN REFMGR.CITE <Refman><Cite><Author>Larson</Author><Year>1999</Year><RecNum>563</RecNum><IDText>Quality of life before and after radiofrequency catheter ablation in patients with drug refractory atrioventricular nodal reentrant tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>563</Ref_ID><Title_Primary>Quality of life before and after radiofrequency catheter ablation in patients with drug refractory atrioventricular nodal reentrant tachycardia</Title_Primary><Authors_Primary>Larson,M.S.</Authors_Primary><Authors_Primary>McDonald,K.</Authors_Primary><Authors_Primary>Young,C.</Authors_Primary><Authors_Primary>Sung,R.</Authors_Primary><Authors_Primary>Hlatky,M.A.</Authors_Primary><Date_Primary>1999/8/15</Date_Primary><Keywords>Aged</Keywords><Keywords>Anti-Arrhythmia Agents</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>drug therapy</Keywords><Keywords>Electrocardiography</Keywords><Keywords>Female</Keywords><Keywords>Follow-Up Studies</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>psychology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Research</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>Risk Factors</Keywords><Keywords>surgery</Keywords><Keywords>Survival Rate</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>therapeutic use</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>471</Start_Page><End_Page>3, A9</End_Page><Periodical>Am.J.Cardiol.</Periodical><Volume>84</Volume><Issue>4</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>S0002-9149(99)00338-0</Misc_3><Address>Department of Health Research and Policy, Stanford University School of Medicine, California 94305-5405, USA</Address><Web_URL>PM:10468092</Web_URL><ZZ_JournalFull><f name="System">Am.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(379)10468092Retrospective single center evaluation161 pts w/ RFA for drug-refractory AVNRTNot specifiedDuke Activity Status Index used for physical function, Symptom Checklist—Frequency and Severity Scale, both used in telephone surveyMean number of sxs declined from 5.83.1 (p<0.001)Moderate-severe sxs declined 4.61.1 (p<0.0001)Urgent care visits declined from mean of 4.60.4/y (p<0.001)Heath score increased from mean of 56.677.3 (p<0.0001)Pt utility increased from mean of 0.71 to 0.88 (p<0.0001)RFA effective in improving QOL. Although single center, Kaiser is a large health care system.Susceptible to recall bias*Goldberg AS2002PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbGRiZXJnPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkdvbGRiZXJnPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48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ADDIN EN.CITE.DATA (380)11988206 Prospective comparison on long-term effects of QOL between RFA and pharmacologic therapy for PSVT83 pts w/ newly-diagnosed symptomatic PSVTAverage number of drugs 1.49/pt(BB most common)39 w/ initial RFA, 44 w/ initial medical therapy (of which 22/44 underwent RFA)Referred specifically for ablationExcluded AF and atrial flutterAVNRT (67%)AVRT w/ AP (28%)AT (5%)SF-36 used to measure QOL after 1-y and 5-y f/uAt 5-y f/u, both RFA and pharmacologic therapy w/ improved scores (cumulative p<0.05 and p<0.001, respectively)RFA significantly improved in physical function, physical role, emotional role, mental health (p<0.05)At 5-y f/u, there was greater sx reduction in RFA group (p<0.01) compared to medical therapyImprovement in sxs who underwent initial RFA or cross-over to RFA after 5 y, compared to medical therapy (p<0.05)Over 5 y, the average cumulative cost for pts in the ablation therapy group was $7,507± $1,098. The cumulative cost for pts in medical therapy group was significantly lower than in pts initially treated w/ ablation therapy: $6,249±$1,421, p<0.05.N/ARFA was associated w/ higher QOL in all health concepts at 1 y; this improvement was sustained in the physical function, emotional role, physical role, and mental health subsets at 5 y.Cost estimated to be higher in RFA group.Offers 5 y f/u and includes pts who were not drug-refractory.Walfridsson U2005 ADDIN REFMGR.CITE <Refman><Cite><Author>Walfridsson</Author><Year>2005</Year><RecNum>48</RecNum><IDText>The impact of supraventricular tachycardias on driving ability in patients referred for radiofrequency catheter ablation</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>48</Ref_ID><Title_Primary>The impact of supraventricular tachycardias on driving ability in patients referred for radiofrequency catheter ablation</Title_Primary><Authors_Primary>Walfridsson,U.</Authors_Primary><Authors_Primary>Walfridsson,H.</Authors_Primary><Date_Primary>2005/3</Date_Primary><Keywords>Adult</Keywords><Keywords>Automobile Driving</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Chi-Square Distribution</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Interviews as Topic</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Statistics,Nonparametric</Keywords><Keywords>surgery</Keywords><Keywords>Syncope</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Reprint>Not in File</Reprint><Start_Page>191</Start_Page><End_Page>195</End_Page><Periodical>Pacing Clin.Electrophysiol.</Periodical><Volume>28</Volume><Issue>3</Issue><ISSN_ISBN>0147-8389</ISSN_ISBN><Misc_3>PACE9753;10.1111/j.1540-8159.2005.09753.x</Misc_3><Address>Department of Cardiology, University Hospital, Linkoping, Sweden. ulla.walfridsson@lio.se</Address><Web_URL>PM:15733177</Web_URL><ZZ_JournalFull><f name="System">Pacing and clinical electrophysiology : PACE</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Pacing Clin.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(15)15733177Impact of PSVT on perceived ability to drive N=301Interview w/ structured questionsPts referred for ablation, of which 226 were active driversN/ASxs among drivers (irrespective of driving): fatigue 77%, dizziness 47%, cold sweat (52%), near syncope (50%), syncope (14%). Women more symptomatic than men (p<0.05). 57% had sxs while driving, 42% of those pts needed to stop driving and 24 pts regarded their tachycardia as an obstacle to driving, w/ correlation (p<0.001) if near syncope was a sxPSVT common while driving. Correlation of near syncope as sx w/ deciding that PSVT was obstacle to driving.Meissner A2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laXNzbmVyPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPk1laXNzbmVyPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN EN.CITE.DATA (381)19158961 QOL pre-post RFA309AVNRT (n=230)AVRT (n=66)AT (n=13)QOL following ablation, measured w/ SF-36 and Symptom Checklist-Frequency and Severity ScaleF/u 4.5±1.3 yQOL significantly improved in AVNRT (p<0.0005) and AVRT (p<0.04); AT p=NSPre-RFA sxs of tachycardia (91.5%), increased incidence of tachycardia episodes over time (78.1%), anxiety (55.5%), reduced physical capacity in daily life (52%) significantly improved post RFA (p<0.0001)Large series w/ long-term f/u.Walfridsson U2009PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbGZyaWRzc29uPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh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 REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldhbGZyaWRzc29uPC9BdXRob3I+PFllYXI+MjAwOTwvWWVh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 EN.CITE.DATA (19)19702600QOL SurveyPts w/ AVRT and AVNRT referred for RFAAVNRT (n=97)AVRT (n=79)QOL scores measured by SF-36 and EuroQol, and disease-specific questions, compared w/ reference groupQOL scores were significantly lower for pts w/ AVNRT compared to AVRT in several SF-36 measures (physical functioning, general health, and bodily pain) as w/ EuroQol.Scores significantly affected by occurrence >once a mo, arrhythmia duration, and whether sxs occurred not only during exercise but also at rest Arrhythmia recurrence important to consider when setting priorities for treatment w/ RFA. Wood KA2010PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldvb2Q8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPldvb2Q8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (288)20109982QOL pre-post RFA52AVNRT (n=30)AVRT (n=16)AT (n=6)QOL following ablation, measured w/ Patient Perception scale, 3 subscales of SF-36, 2 subscales from Medical Outcomes Study, disease-specific measuresSignificant improvement in most sxs post-ablation (p<0.05)No sxs completely eliminated at one mo f/uEffect greater in womenAblation improves QOL on several measures, both generic and PSVT-specific measures.Short f/u.Yildrim O2010 ADDIN REFMGR.CITE <Refman><Cite><Author>Yildirim</Author><Year>2012</Year><RecNum>349</RecNum><IDText>The effect of radiofrequency ablation treatment on quality of life and anxiety in patients with supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>349</Ref_ID><Title_Primary>The effect of radiofrequency ablation treatment on quality of life and anxiety in patients with supraventricular tachycardia</Title_Primary><Authors_Primary>Yildirim,O.</Authors_Primary><Authors_Primary>Yontar,O.C.</Authors_Primary><Authors_Primary>Semiz,M.</Authors_Primary><Authors_Primary>Erdem,A.</Authors_Primary><Authors_Primary>Canan,F.</Authors_Primary><Authors_Primary>Yontar,G.</Authors_Primary><Authors_Primary>Kugu,N.</Authors_Primary><Date_Primary>2012/12</Date_Primary><Keywords>Adult</Keywords><Keywords>Anxiety</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>psychology</Keywords><Keywords>Quality of Life</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Reprint>Not in File</Reprint><Start_Page>2108</Start_Page><End_Page>2112</End_Page><Periodical>Eur.Rev.Med.Pharmacol.Sci.</Periodical><Volume>16</Volume><Issue>15</Issue><ISSN_ISBN>1128-3602</ISSN_ISBN><Address>Department of Psychiatry, Abant Izzet Baysal University, Bolu, Turkey</Address><Web_URL>PM:23280027</Web_URL><ZZ_JournalFull><f name="System">European review for medical and pharmacological sciences</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Eur.Rev.Med.Pharmacol.Sci.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(382)23280027QOL pre-post RFA50 AVNRT (n=28)AVRT (n=22)WHOQOL-BREF and STAI domainsPrior to RFA, greater than average anxiety score (p<0.05)All items significantly improved post-RFA—anxiety, QOL, and health satisfaction scoresRFA improves anxiety and QOL.Limited by 3 mo f/u, but consistent w/ prior work.Farkowski MM2014PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZhcmtvd3NraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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=
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkZhcmtvd3NraTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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=
ADDIN EN.CITE.DATA (383)24919538Prospective cohort, gender-related differences in outcomes pre-post RFA64AVNRT (n=40, 32 women, 8 men)AVRT (n=26, 11 women, 15 men)(2 pts did not complete f/u)QOL measured by PPAQ, EQ-5D-3L41 women completed survey.No significant baseline differences except AVNRT prevalence, and HRQOL by genderWomen reported higher severity of sxs on PPAQ than men (p<0.001)At 2 mo after RFA, women reported higher severity of sxs (p=0.02) on PPAQ and more heart skipping than men (p=0.0014)No significant difference in healthcare resource utilization during the y preceding RFAAADs more often prescribed to women pre-procedure (p=0.022)Small but significant gender-related difference in outcome of RFA in pts w/ AVNRT or AVRT measured w/ a disease-specific instrumentNo significant difference in QOL or access to healthcare resources between women and men.*Study addressed both CE and QoLAAD indicates antiarrhythmic drug; ADL, activities of daily living; AF, atrial fibrillation; AP, accessory pathway; AT, atrial tachycardia; AVJ, atrioventricular junction; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; BB, beta blocker; CCB, calcium channel blocker; CE, cost effectiveness; EQ-5D-3L, EuroQol Research Foundation questionnaire; ETT, exercisetreadmill test; f/u, follow up; HRQOL, health-related quality of life; N/A, not applicable; PPAQ, Patient Perception of Arrhythmia Questionnaire; PSVT, paroxysmal supraventricular tachycardia; pt, patient; QOL, quality of life; RFA, radiofrequency ablation; SF-36, Short Form (36) Health Survey; s/p, status post; STAI, State and Trait Anxiety Inventory; sx, symptom; VT, ventricular tachycardia; w/, with; WHOQOL-BREF, World Health Organization Quality of Life Scale; and WPW, Wolff-Parkison-White syndrome. Data Supplement 23. Nonrandomized Trials, Observational Studies, and/or Registries of Cost Effectiveness – Section 11 StudyName, Author, YearStudy Type/DesignStudy SizeInclusion/Exclusion CriteriaPrimary EndpointResults/p ValuesSummary/ConclusionsDe Buitlier M1990 ADDIN REFMGR.CITE <Refman><Cite><Author>de Buitleir</Author><Year>1990</Year><RecNum>564</RecNum><IDText>Cost of catheter versus surgical ablation in the Wolff-Parkinson-White syndrome</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>564</Ref_ID><Title_Primary>Cost of catheter versus surgical ablation in the Wolff-Parkinson-White syndrome</Title_Primary><Authors_Primary>de Buitleir,M.</Authors_Primary><Authors_Primary>Bove,E.L.</Authors_Primary><Authors_Primary>Schmaltz,S.</Authors_Primary><Authors_Primary>Kadish,A.H.</Authors_Primary><Authors_Primary>Morady,F.</Authors_Primary><Date_Primary>1990/7/15</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Costs and Cost Analysis</Keywords><Keywords>economics</Keywords><Keywords>Electrocoagulation</Keywords><Keywords>Female</Keywords><Keywords>Heart Conduction System</Keywords><Keywords>Hospitalization</Keywords><Keywords>Humans</Keywords><Keywords>Length of Stay</Keywords><Keywords>Male</Keywords><Keywords>Medicine</Keywords><Keywords>Michigan</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Retrospective Studies</Keywords><Keywords>surgery</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Keywords>Wolff-Parkinson-White Syndrome</Keywords><Keywords>Work</Keywords><Reprint>Not in File</Reprint><Start_Page>189</Start_Page><End_Page>192</End_Page><Periodical>Am.J.Cardiol.</Periodical><Volume>66</Volume><Issue>2</Issue><ISSN_ISBN>0002-9149</ISSN_ISBN><Misc_3>0002-9149(90)90586-P</Misc_3><Address>Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109</Address><Web_URL>PM:2371949</Web_URL><ZZ_JournalFull><f name="System">Am.J.Cardiol.</f></ZZ_JournalFull><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(384)2371949Retrospective cohort study to evaluate CE of AP RFA c/w surgical ablation22Pts w/ APs who underwent RFA or surgical ablation(n=11 RFA)(n=11 surgical ablation)Health care cost, w/ secondary endpoint LOSRFA success: 73% (all w/ posteroseptal AP)Surgical success: 100% (right, left lateral, posteroseptal AP)RFA LOS 6±2 dSurgical LOS 8±4 dRFA cost: 14,116±4,493 c/w 34,175±5,434 in surgical group (p<0.0001).Mean time lost from work or school was 10± 5 d in RFA group c/w 60±16 d in surgical group (p<0.01).1988 dollarsRFA of APs substantially lower in cost and LOS c/w surgical ablation.De Buitlier M1991PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEJ1aXRsZWlyPC9BdXRob3I+PFllYXI+MTk5MTwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIEJ1aXRsZWlyPC9BdXRob3I+PFllYXI+MTk5MTwvWWVh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ADDIN EN.CITE.DATA (385)1746469Retrospective cohort study to evaluate CE of AP RFA c/w surgical ablation50Pts w/ APs who underwent RFA or surgical ablation(n=25 RFA, 1990)(n=25 surgical ablation, 1989)Health care cost, w/ secondary endpoint LOSSuccess rate was 96% for both groups. Mean LOS was 3±1 d in RFA group and 9±4 d in surgical group (p<0.0001). RFA total cost $14,919 c/w $53,265 in the surgical group (p<0.0001). 1990/1991 dollarsRFA of APs substantially lower in cost and LOS c/w surgical ablation.Kalbfleisch SJ1992PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5MjwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5MjwvWWVh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ADDIN EN.CITE.DATA (386)1593054Retrospective review to establish cost-advantage of RFA for AVNRT15Symptomatic AVNRT who underwent RFARFA cost of $15,893 would be advantageous after 10 y in pts who visit ED once per y (in study medical therapy more expensive after 2 y due to frequent ED visits in study population). Perspective: ptOutcomes: annual chargesN/A1991 dollarsEarly report using hospital charges showing cost advantage of RFA for AVNRTMedical therapy at the time more expensive given drugs may not have been at generic prices.Hogenhuis W1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvZ2VuaHVpczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkhvZ2VuaHVpczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+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ADDIN EN.CITE.DATA (387)8222191 CE of management in WPWMarkov model, none-specified, but costs estimated from convenience sample of 13 ptsN/AEvaluation of 5 different strategies:-observation- observation until SCD-therapy guided by noninvasive monitoring, -initial RFA -initial surgical ablationPerspective: largely pt-perspectiveOutcomes: QALY and mortality, using Markov ModelRFA yields life expectancy greater than or equal to other strategies40 y-old pt:Observation: $2360RFA: $5,150-6,250Surgery: $15,120Observation w/ RFA at cardiac arrest: $16,860Drug therapy: $20,250In cardiac arrest survivors and pts who have had PSVT/AF w/ hemodynamic compromise, RFA should both prolong survival and save resourcesFor pts w/ PSVT/AF w/o hemodynamic compromise, the marginal cost-effectiveness of attempted RFA ranges from $6,600 per QALY gained for 20-y old pts to $19,000 per QALY gained for 60-y old pts. For asymptomatic pts, RFA costs from $174,000 per QALY gained for 20-y old pts to $540,000 per QALY gained for 60-y old ptsSupports RFA in WPW syndrome who survive cardiac arrest or who experience PSVT/AF. but also supports the current practice of observing asymptomatic ptsKalbfleisch SJ1993PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5MzwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkthbGJmbGVpc2NoPC9BdXRob3I+PFllYXI+MTk5MzwvWWVh
cj48UmVjTnVtPjU2NzwvUmVjTnVtPjxJRFRleHQ+U2FmZXR5LCBmZWFzaWJpbGl0eSBhbmQgY29z
dCBvZiBvdXRwYXRpZW50IHJhZGlvZnJlcXVlbmN5IGNhdGhldGVyIGFibGF0aW9uIG9mIGFjY2Vz
c29yeSBhdHJpb3ZlbnRyaWN1bGFyIGNvbm5lY3Rpb25zPC9JRFRleHQ+PE1ETCBSZWZfVHlwZT0i
Sm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+NTY3PC9SZWZfSUQ+
PFRpdGxlX1ByaW1hcnk+U2FmZXR5LCBmZWFzaWJpbGl0eSBhbmQgY29zdCBvZiBvdXRwYXRpZW50
IHJhZGlvZnJlcXVlbmN5IGNhdGhldGVyIGFibGF0aW9uIG9mIGFjY2Vzc29yeSBhdHJpb3ZlbnRy
aWN1bGFyIGNvbm5lY3Rpb25zPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+S2FsYmZs
ZWlzY2gsUy5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+ZWwtQXRhc3NpLFIu
PC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5DYWxraW5zLEguPC9BdXRob3JzX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5MYW5nYmVyZyxKLkouPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5Nb3JhZHksRi48L0F1dGhvcnNfUHJpbWFyeT48RGF0ZV9QcmltYXJ5PjE5
OTMvMy8xPC9EYXRlX1ByaW1hcnk+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+
YWR2ZXJzZSBlZmZlY3RzPC9LZXl3b3Jkcz48S2V5d29yZHM+QW1idWxhdG9yeSBTdXJnaWNhbCBQ
cm9jZWR1cmVzPC9LZXl3b3Jkcz48S2V5d29yZHM+YW5hbHlzaXM8L0tleXdvcmRzPjxLZXl3b3Jk
cz5BcnRlcmllczwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlvdmVudHJpY3VsYXIgTm9kZTwvS2V5
d29yZHM+PEtleXdvcmRzPkJvZHkgV2VpZ2h0PC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIg
QWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5Db3N0cyBhbmQgQ29zdCBBbmFseXNpczwvS2V5
d29yZHM+PEtleXdvcmRzPmVjb25vbWljczwvS2V5d29yZHM+PEtleXdvcmRzPmVwaWRlbWlvbG9n
eTwvS2V5d29yZHM+PEtleXdvcmRzPkZlYXNpYmlsaXR5IFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3
b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Ib3NwaXRhbGl6YXRpb248L0tleXdvcmRz
PjxLZXl3b3Jkcz5Ib3NwaXRhbHMsVW5pdmVyc2l0eTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFu
czwvS2V5d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NZWRpY2luZTwv
S2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWNoaWdhbjwv
S2V5d29yZHM+PEtleXdvcmRzPk9iZXNpdHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5PdXRjb21lIGFu
ZCBQcm9jZXNzIEFzc2Vzc21lbnQgKEhlYWx0aCBDYXJlKTwvS2V5d29yZHM+PEtleXdvcmRzPlBh
dGllbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1ZGllczwvS2V5d29yZHM+
PEtleXdvcmRzPlB1bmN0dXJlczwvS2V5d29yZHM+PEtleXdvcmRzPlJpc2sgRmFjdG9yczwvS2V5
d29yZHM+PEtleXdvcmRzPlNhZmV0eTwvS2V5d29yZHM+PEtleXdvcmRzPnN0YW5kYXJkczwvS2V5
d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3b3Jkcz5UaW1lIEZhY3RvcnM8
L0tleXdvcmRzPjxLZXl3b3Jkcz5Xb2xmZi1QYXJraW5zb24tV2hpdGUgU3luZHJvbWU8L0tleXdv
cmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxTdGFydF9QYWdlPjU2NzwvU3RhcnRf
UGFnZT48RW5kX1BhZ2U+NTcwPC9FbmRfUGFnZT48UGVyaW9kaWNhbD5KLkFtLkNvbGwuQ2FyZGlv
bC48L1BlcmlvZGljYWw+PFZvbHVtZT4yMTwvVm9sdW1lPjxJc3N1ZT4zPC9Jc3N1ZT48SVNTTl9J
U0JOPjA3MzUtMTA5NzwvSVNTTl9JU0JOPjxNaXNjXzM+MDczNS0xMDk3KDkzKTkwMDg2LUc8L01p
c2NfMz48QWRkcmVzcz5EZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBVbml2ZXJzaXR5
IG9mIE1pY2hpZ2FuIE1lZGljYWwgQ2VudGVyLCBBbm4gQXJib3IgNDgxMDktMDAyMjwvQWRkcmVz
cz48V2ViX1VSTD5QTTo4NDM2NzM2PC9XZWJfVVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJT
eXN0ZW0iPkouQW0uQ29sbC5DYXJkaW9sLjwvZj48L1paX0pvdXJuYWxGdWxsPjxaWl9Xb3JrZm9y
bUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPm==
ADDIN EN.CITE.DATA (388)8436736Prospective cohort study to evaluate safety, feasibility, and cost of AP RFA as an outpt137Exclusion: <13 or >70 y, anteroseptal AP, obesity, or clinical indication for hospitalizationRFA of AP cost as outpt procedure97% success rate, w/ 73% performed as outpatients. In 70 cases the pt was discharged the d of ablation, and in 30 cases the pt required a short (≤18 h) overnight stay due to scheduling issues.Mean duration of observation was 4.8±1.5 h for outpts and 15±1.4 h for pts who underwent overnight hospitalization. Mean cost of the procedure was $10,183±$1,082 in 30 pts studied for cost analysis. 22 outpts vs. 8 overnight pts :Total charges: $9,873 vs. $11,034 (p<0.01)Professional fees: $6,163 vs. $6,286 (p=NS)Hospital charges: $3,710 vs. $4,748 (p<0.01)2 pts w/ complications: femoral artery pseudoaneurysm notes 3-4 wk after procedure, one in outpt, one after 13 h overnight stay.Outpt ablation of AP, w/ possible overnight observation, is feasible in low-risk ptsKertes PJ1993 ADDIN REFMGR.CITE <Refman><Cite><Author>Kertes</Author><Year>1993</Year><RecNum>568</RecNum><IDText>Cost effectiveness of radiofrequency catheter ablation in the treatment of symptomatic supraventricular tachyarrhythmias</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>568</Ref_ID><Title_Primary>Cost effectiveness of radiofrequency catheter ablation in the treatment of symptomatic supraventricular tachyarrhythmias</Title_Primary><Authors_Primary>Kertes,P.J.</Authors_Primary><Authors_Primary>Kalman,J.M.</Authors_Primary><Authors_Primary>Tonkin,A.M.</Authors_Primary><Date_Primary>1993/8</Date_Primary><Keywords>Adolescent</Keywords><Keywords>Adult</Keywords><Keywords>Aged</Keywords><Keywords>analysis</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Cost-Benefit Analysis</Keywords><Keywords>drug therapy</Keywords><Keywords>Echocardiography</Keywords><Keywords>economics</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Female</Keywords><Keywords>Humans</Keywords><Keywords>Male</Keywords><Keywords>Medical Records</Keywords><Keywords>methods</Keywords><Keywords>Middle Aged</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Supraventricular</Keywords><Keywords>therapy</Keywords><Keywords>Time</Keywords><Keywords>Victoria</Keywords><Reprint>Not in File</Reprint><Start_Page>433</Start_Page><End_Page>436</End_Page><Periodical>Aust.N.Z.J.Med.</Periodical><Volume>23</Volume><Issue>4</Issue><ISSN_ISBN>0004-8291</ISSN_ISBN><Address>Department of Cardiology, Austin Hospital Melbourne, Vic., Heidelberg</Address><Web_URL>PM:8240167</Web_URL><ZZ_JournalFull><f name="System">Australian and New Zealand journal of medicine</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Aust.N.Z.J.Med.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(389)8240167CE of RFA compared to AADs in Australia26AVNRT (n=16)WPW (n=10)Mean cost of RFA $4067, c/w AAD of $700/ yNOTE: these are likely Australian dollars, although authors do not specifyExtrapolating over 20 y and allowing for an annual 5% inflation factor, RFA becomes cost saving in 5.5 y Over 20 y, AAD estimated at 4-5 times more expensive than RFPerspective: pt and societal perspectiveOutcomes: cost analysis w/ “cost-saving” criterion used to define effectiveness, on the assumption that RFA is at least as effective as AADs in long-term control of PSVT; authors used annual chargesN/ARFA more cost-effective than AADs.Limited to Australian population, but results consistent w/ other series.Used pt data in constructing cost-analysis, not simulation.Ikeda T1994PFJlZm1hbj48Q2l0ZT48QXV0aG9yPklrZWRhPC9BdXRob3I+PFllYXI+MTk5NDwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPklrZWRhPC9BdXRob3I+PFllYXI+MTk5NDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (390)7823285Prospective cohort, CE evaluation of CE of RFA for PSVT20Symptomatic PSVT, on AADs, all w/ successful RFAAVNRT (n=5)WPW (n=15)Mean total charge for ablation 982,806 yen and 5.7 times the outpt charges in the previous yMean total life-expectancy charges w/ AADs were estimated at 7,064,726 yen, 41.0 times the outpt chargesTotal RFA charge 14% of total estimated charges of estimated lifetime medical treatment w/o RFA (p<0.001) Perspective: pt-perspective, societal componentOutcomes: total life-expectancy charges, total ablation chargesN/ASmall study, limited to Japan, but suggests RFA effective and reduces medical costs.Utilizes hospital charges, and not a cost-simulation model.*Bathina MN1998PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdGhpbmE8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkJhdGhpbmE8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (378)9732885Prospective comparison of the impact of QOL and CE between RFA and pharmacologic therapy for PSVT79 w/ newly-documented PSVT Average number of drugs 1.35/pt(CCB, BB, most common)Exclusions: drug-refractory pts, prior treatment, AF, atrial flutter, preexcitationSF-36 and direct costsPerspective: pt-perspectiveOutcomes: direct hospital chargesRFA vs. medicationPotential long-term costs similar, but w/ specific assumptions about ED visits, pharmacologic costs will exceed RFAFirst study to prospectively evaluate QOL and resource utilization between RFA vs. medical therapy.Cumulative cost of medical therapy equal to, or less than RFA. This is in contrast to studies by Cheng and Ikeda, which have stronger methodology. Cheng CH 2000PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNoZW5nPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (60)11103056Comparison of CE of RFA w/ medical management of PSVTSymptomatic pts w/ 4.6 unscheduled visits/y for arrhythmia while on long-term drug therapyRFA:Estimated population:AVNRT: 65%AVRT w/ concealed AP: 30%Efficacy estimates:AVNRT: 97%AVRT w/ concealed AP: 93%Recurrence estimates:AVNRT: 5%AVRT w/ concealed AP: 8%Drug efficacy: 60%Perspective: societalOutcomes: Costs (office visit, annual drug rx, EP study, RFA, PPM, PPM replacement)QALYLife-ysMarginal CE ratiosW/ monthly episodes of PSVT, RFA most effective and least expensive optionRFA reduced lifetime medical expenditures by $27,940 compared w/ long-term pharmacologic therapyLifetime costs:RFA: $61,880Long-term drug rx:$89,820Episodic drug rx:$143,530RFA improved quality-adjusted life expectancy by 3.10 QALYs.RFA improves QOL and reduces costs when treating highly symptomatic pts.Effects in less symptomatic not studiesDewland TA2013 ADDIN REFMGR.CITE <Refman><Cite><Author>Dewland</Author><Year>2014</Year><RecNum>353</RecNum><IDText>Healthcare utilization and clinical outcomes after catheter ablation of atrial flutter</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>353</Ref_ID><Title_Primary>Healthcare utilization and clinical outcomes after catheter ablation of atrial flutter</Title_Primary><Authors_Primary>Dewland,T.A.</Authors_Primary><Authors_Primary>Glidden,D.V.</Authors_Primary><Authors_Primary>Marcus,G.M.</Authors_Primary><Date_Primary>2014</Date_Primary><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>diagnosis</Keywords><Keywords>Electrophysiology</Keywords><Keywords>Emergencies</Keywords><Keywords>epidemiology</Keywords><Keywords>Hospitalization</Keywords><Keywords>Medicine</Keywords><Keywords>Patients</Keywords><Keywords>Proportional Hazards Models</Keywords><Keywords>Research</Keywords><Keywords>Risk</Keywords><Keywords>United States</Keywords><Keywords>utilization</Keywords><Reprint>Not in File</Reprint><Start_Page>e100509</Start_Page><Periodical>PLoS One</Periodical><Volume>9</Volume><Issue>7</Issue><User_Def_5>PMC4077565</User_Def_5><ISSN_ISBN>1932-6203</ISSN_ISBN><Misc_3>10.1371/journal.pone.0100509;PONE-D-13-52331</Misc_3><Address>Department of Internal Medicine, Division of Cardiology, Electrophysiology Section, University of California San Francisco, San Francisco, California, United States of America
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Department of Internal Medicine, Division of Cardiology, Electrophysiology Section, University of California San Francisco, San Francisco, California, United States of America</Address><Web_URL>PM:24983868</Web_URL><ZZ_JournalStdAbbrev><f name="System">PLoS One</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(391)24983868Observational cohortPts w/ atrial flutter in the California HCUP database, 2005-2009 (n=33,004), median f/u 2/1 yExclusion: Non-California residence, concomitant AF, missing admission date dataWhether catheter ablation of atrial flutter associated w/ reductions in healthcare utilization, AF, or CVA2,733 (8.2%) underwent catheter ablation. Atrial flutter ablation (in 8.2% of pts) lowered adjusted risk of inpt hospitalization and ED visits (p<0.001); overall hospital-based healthcare utilization (p?=?0.001); and 11% reduction in AF( p?=?0.01). Risk of CVA not reduced after ablation (p?=?0.57).Robust registry data supports early atrial flutter ablation to significantly reduce hospital-based healthcare utilization and risk of AF. *Study addressed both CE and QoLAAD indicates antiarrhythmic drug; AF, atrial fibrillation; AP, accessory pathway; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular tachycardia; BB, beta blocker; CCB, calcium channel blocker; CE, cost effectiveness; CVA, cerebrovascular accident; c/w, consistent with; ED, emergency department; EP, electrophysiological; HCUP, Healthcare Cost and Utilization Project; LOS, length of stay; N/A, not applicable; NS, non-significant; PPM, permanent pacemaker; PSVT, paroxysmal supraventricular tachycardia; pt, patient; QALY, quality-adjusted life year; QOL, quality of life; RF, radiofrequency; RFA, radiofrequency ablation; rx, therapy; SCD, sudden cardiac death; SF-36, Short Form (36) Heatlh Survey; w/, with; and w/o, without. Appendix 1. Acute Drug Therapy for SVT, Intravenous Administration*Drug?Initial DoseSubsequent or Maintenance DosePotential Adverse EffectsPrecautions (Exclude or Use With Caution) and InteractionsNucleoside Adenosine6-mg rapid IV bolus (injected into IV as proximal or as close to the heart as possible), administered over 1–2 s, followed by rapid saline flush If no result within 1–2 min, 12-mg rapid IV bolus; can repeat 12-mg dose 1 time. The safe use of 18-mg bolus doses has been reported PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbWFub3ZpdHM8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFy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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkRvbWFub3ZpdHM8L0F1dGhvcj48WWVhcj4xOTk0PC9ZZWFy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ADDIN EN.CITE.DATA (392).Transient AV block, flushing, chest pain, hypotension, or dyspnea, AF can be initiated or cause decompensation in the presence of pre-excitation, PVCs?/?ventricular tachycardia, bronchospasm (rare), or coronary steal. Minor side effects are usually transient because of adenosine’s very short half-life. AV block greater than first degree or SA node dysfunction (in absence of pacemaker)Reactive airway diseaseConcomitant use of verapamil or digoxinWPWBeta blockersEsmolol 500-mcg/kg IV bolus over 1 minInfusion at 50–300 mcg/kg/min, with repeat boluses between each dosing increaseHypotension, worsening HF, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HFHypotensionCardiogenic shockReactive airway diseaseRenal dysfunctionDrugs with SA and/or AV nodal–blocking propertiesMetoprolol tartrate 2.5–5.0-mg IV bolus over 2 minCan repeat 2.5- to 5.0-mg IV bolus in 10 min, up to 3 dosesHypotension, worsening HF, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HFHypotensionReactive airway diseaseDrugs with SA and/or AV nodal–blocking propertiesPropranolol1 mg IV over 1 minCan repeat 1 mg IV at 2-min intervals, up to 3 dosesHypotension, worsening HF, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Cardiogenic shockReactive airway diseaseDecompensated HFHypotensionHepatic or renal dysfunctionDrugs with SA and/or AV nodal–blocking propertiesNondihydropyridine calcium channel antagonistsDiltiazem0.25-mg/kg IV bolus over 2 minInfusion at 5–10 mg/h, up to 15 mg/hHypotension, worsening HF in patients with pre-existing ventricular dysfunction, bradycardia, abnormal liver function studies, acute hepatic injury (rare)AV block greater than first degree or SA node dysfunction (in absence of pacemaker)WPW with AF?/?atrial flutterHypotension?Decompensated systolic HF/LV dysfunctionDrugs with SA and/or AV nodal–blocking properties Hepatic or renal dysfunctionDiltiazem is a substrate of CYP3A4 (major) and a moderate CYP3A4 inhibitorApixaban, itraconazole, bosutinib, ceritinib, cilostazol, cyclosporine, everolimus, ibrutinib, idelalisib, ivabradine, lomitapide, olaparib, posaconazole, ranolazine, rifampin, simeprevir, voriconazoleVerapamil5–10-mg (0.075–0.15-mg/kg) IV bolus over 2 min If no response, can give an additional 10 mg (0.15 mg/kg) 30 min after first dose; then infusion at 0.005 mg/kg/minHypotension, worsening HF in patients with pre-existing ventricular dysfunction, pulmonary edema in patients with hypertrophic cardiomyopathy, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HF/ LV dysfunctionDrugs with SA and/or AV nodal–blocking properties Hypotension?Cardiogenic shockWPW with AF?/?atrial flutterHepatic or renal dysfunctionVerapamil is a moderate CYP3A4 inhibitor and also inhibits P-glycoproteinContraindicated with dofetilide Itraconazole, bosutinib, ceritinib, cilostazol, colchicine, cyclosporine, everolimus, dabigatran, edoxaban, flecainide, ibrutinib, ivabradine, olaparib, posaconazole, ranolazine, rivaroxaban, rifampin, silodosin, simeprevir, rivaroxaban, rifampin, simvastatin, topotecan, trabectedin, vincristine, voriconazole, grapefruit juiceCardiac glycosidesDigoxin0.25–0.5-mg IV bolus Can repeat 0.25-mg IV bolus, up to maximum dose of 1.0 mg over 24 h (i.e., maximum loading dose 8–12 mcg/kg), given at 6–8-h intervals; maintenance dose based on patient’s age, lean body weight, renal function, and concomitant drugs (IV 2.4–3.6 mcg/kg/d)Anorexia, nausea, vomiting, visual changes and cardiac arrhythmias if digoxin toxicity (associated with levels >2 ng/mL, although symptoms may also occur at lower levels)Renal dysfunctionWPW with AF?/?atrial flutterAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Drugs with AV nodal-blocking propertiesDigoxin is a P-glycoprotein substrateDronedarone (reduce dose by at least 50%), amiodarone (reduce dose by 30%–50%)Verapamil, clarithromycin, cyclosporine, erythromycin, flecainide, itraconazole, posaconazole, propafenone, voriconazole: Monitor digoxin levelsA large retrospective study suggested an increased risk in mortality in patients who were treated with digoxin for newly diagnosed AF or atrial flutter; although the data were collected from a population that was different from SVT patients, digoxin should be used with caution PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlR1cmFraGlhPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlR1cmFraGlhPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48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==
ADDIN EN.CITE.DATA (393).Class III antiarrhythmic agentsAmiodarone150 mg IV over 10 minInfusion at 1 mg/min (360 mg) over next 6 h; then 0.5 mg/min (540 mg) over remaining 18 hHypotension, bradycardia, phlebitis, QT prolongation, torsades de pointes (rare), increased INRSinus or AV conduction disease (in absence of pacemaker)Inflammatory lung disease (acute)Hepatic dysfunctionDrugs with SA and/or AV nodal–blocking propertiesAmiodarone is a substrate of and inhibits p-glycoprotein and CYP2C9 (moderate), CYP2D6 (moderate), and CYP3A4 (weak); amiodarone is a substrate for CYP3A4 (major) and CYP2C8 (major);amiodarone is an inhibitor of OCT2 Reduce warfarin dose by 50% and reduce digoxin dose by 30%–50%Agalsidase alfa, agalsidase beta, azithromycin, bosutinib, ceritinib, colchicine, dabigatran, edoxaban, flecainide, ivabradine, ledipasvir/sofosbuvir, lopinavir, lopinavir/ritonavir, lovastatin, nelfinavir, pazopanib, propafenone, simvastatin, ritonavir, rivaroxaban, saquinavir, sofosbuvir, topotecan, vincristine, grapefruit juiceIbutilideContraindicated when QTc >440 ms║; 1 mg over 10 min (if ≥60 kg); if <60 kg, then 0.01 mg/kgCan repeat 1 mg once, if the arrhythmia does not terminate within 10 min§QT prolongation, torsades de pointes, AV blockProlonged QT intervalHistory of torsades de pointesAvoid other QT interval–prolonging drugsConcurrent administration of high-dose magnesium has been associated with enhanced efficacy and safety PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZWlud2VuZGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlN0ZWlud2VuZGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh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ADDIN EN.CITE.DATA (206, 394) Note: For this reference table, drugs are presented in alphabetical order within the drug classes, not by COR and LOE. *When 1 drug is used in combination with other drugs, appropriate dosing adjustments should be made with consideration of at least additive effects during dosage titration. All potential drug–drug interactions are not included in this list. For a more detailed list of drug–drug interactions, clinicians should consult additional resources. ?If hypotension is a consideration, a slow infusion of diltiazem (2.5 mg/min) or verapamil (1 mg/min) for up to 20 minutes may lessen the potential for hypotension PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051
bT4yPC9SZWNOdW0+PElEVGV4dD5TbG93IGluZnVzaW9uIG9mIGNhbGNpdW0gY2hhbm5lbCBibG9j
a2VycyBjb21wYXJlZCB3aXRoIGludHJhdmVub3VzIGFkZW5vc2luZSBpbiB0aGUgZW1lcmdlbmN5
IHRyZWF0bWVudCBvZiBzdXByYXZlbnRyaWN1bGFyIHRhY2h5Y2FyZGlhPC9JRFRleHQ+PE1ETCBS
ZWZfVHlwZT0iSm91cm5hbCI+PFJlZl9UeXBlPkpvdXJuYWw8L1JlZl9UeXBlPjxSZWZfSUQ+Mjwv
UmVmX0lEPjxUaXRsZV9QcmltYXJ5PlNsb3cgaW5mdXNpb24gb2YgY2FsY2l1bSBjaGFubmVsIGJs
b2NrZXJzIGNvbXBhcmVkIHdpdGggaW50cmF2ZW5vdXMgYWRlbm9zaW5lIGluIHRoZSBlbWVyZ2Vu
Y3kgdHJlYXRtZW50IG9mIHN1cHJhdmVudHJpY3VsYXIgdGFjaHljYXJkaWE8L1RpdGxlX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5MaW0sUy5ILjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1By
aW1hcnk+QW5hbnRoYXJhbWFuLFYuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5U
ZW8sVy5TLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2hhbixZLkguPC9BdXRo
b3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA5LzU8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+
QWRlbm9zaW5lPC9LZXl3b3Jkcz48S2V5d29yZHM+YWRtaW5pc3RyYXRpb24gJmFtcDsgZG9zYWdl
PC9LZXl3b3Jkcz48S2V5d29yZHM+QWR1bHQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5
dGhtaWEgQWdlbnRzPC9LZXl3b3Jkcz48S2V5d29yZHM+Qmxvb2QgUHJlc3N1cmU8L0tleXdvcmRz
PjxLZXl3b3Jkcz5DYWxjaXVtIENoYW5uZWwgQmxvY2tlcnM8L0tleXdvcmRzPjxLZXl3b3Jkcz5E
aWx0aWF6ZW08L0tleXdvcmRzPjxLZXl3b3Jkcz5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCxE
cnVnPC9LZXl3b3Jkcz48S2V5d29yZHM+RHJ1ZyBBZG1pbmlzdHJhdGlvbiBTY2hlZHVsZTwvS2V5
d29yZHM+PEtleXdvcmRzPmRydWcgZWZmZWN0czwvS2V5d29yZHM+PEtleXdvcmRzPmRydWcgdGhl
cmFweTwvS2V5d29yZHM+PEtleXdvcmRzPkVtZXJnZW5jeSBNZWRpY2FsIFNlcnZpY2VzPC9LZXl3
b3Jkcz48S2V5d29yZHM+RmVtYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQgUmF0ZTwvS2V5
d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZnVzaW9ucyxJbnRy
YXZlbm91czwvS2V5d29yZHM+PEtleXdvcmRzPkluamVjdGlvbnMsSW50cmF2ZW5vdXM8L0tleXdv
cmRzPjxLZXl3b3Jkcz5NYWxlPC9LZXl3b3Jkcz48S2V5d29yZHM+bWV0aG9kczwvS2V5d29yZHM+
PEtleXdvcmRzPk1pZGRsZSBBZ2VkPC9LZXl3b3Jkcz48S2V5d29yZHM+UHJvc3BlY3RpdmUgU3R1
ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLFN1cHJhdmVudHJpY3VsYXI8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5UcmVhdG1lbnQgT3V0Y29tZTwvS2V5d29yZHM+PEtleXdvcmRzPlZl
cmFwYW1pbDwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1JlcHJpbnQ+PFN0YXJ0X1Bh
Z2U+NTIzPC9TdGFydF9QYWdlPjxFbmRfUGFnZT41Mjg8L0VuZF9QYWdlPjxQZXJpb2RpY2FsPlJl
c3VzY2l0YXRpb248L1BlcmlvZGljYWw+PFZvbHVtZT44MDwvVm9sdW1lPjxJc3N1ZT41PC9Jc3N1
ZT48SVNTTl9JU0JOPjAzMDAtOTU3MjwvSVNTTl9JU0JOPjxNaXNjXzM+UzAzMDAtOTU3MigwOSkw
MDA1Ny00OzEwLjEwMTYvai5yZXN1c2NpdGF0aW9uLjIwMDkuMDEuMDE3PC9NaXNjXzM+PEFkZHJl
c3M+RGVwYXJ0bWVudCBvZiBFbWVyZ2VuY3kgTWVkaWNpbmUsIFNpbmdhcG9yZSBHZW5lcmFsIEhv
c3BpdGFsLCBPdXRyYW0gUm9hZCwgU2luZ2Fwb3JlIDE2OTYwOCwgU2luZ2Fwb3JlPC9BZGRyZXNz
PjxXZWJfVVJMPlBNOjE5MjYxMzY3PC9XZWJfVVJMPjxaWl9Kb3VybmFsU3RkQWJicmV2PjxmIG5h
bWU9IlN5c3RlbSI+UmVzdXNjaXRhdGlvbjwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dv
cmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PC9SZWZtYW4+
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkxpbTwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051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 EN.CITE.DATA (38). §The infusion should be stopped as soon as the arrhythmia is terminated or in the event of sustained or nonsustained ventricular tachycardia or marked prolongation of QT or corrected QT interval. ║QTc calculation used the Bazett’s Formula in most clinical studies. Patients should be observed with continuous ECG monitoring for at least 4 h after infusion or until QTc has returned to baseline.AF indicates atrial fibrillation; AV, atrioventricular; BID, twice daily; CrCl, creatinine clearance; ECG, electrocardiogram/electrocardiographic; HF, heart failure; INR, international normalized ratio; LV, left ventricular; QD, once daily; QID, four times a day; QTc, corrected QT interval; SA, sinoatrial; SVT, supraventricular tachycardia; TID, 3-times a day; and WPW, Wolff-Parkinson-White. Appendix 2. Ongoing Drug Therapy for SVT, Oral Administration*Drug?Initial Daily Dose(s)Maximum Total Daily Maintenance DosePotential Adverse EffectsPrecautions (Exclude or Use With Caution) and InteractionsBeta blockersAtenolol25–50 mg QD100 mg QD(reduced dosing in patients with severe renal dysfunction)Hypotension, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HFHypotensionReactive airway disease Severe renal dysfunctionDrugs with SA and/or AV nodal–blocking propertiesMetoprolol tartrate25 mg BID 200 mg BIDHypotension, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HFHypotensionReactive airway disease Drugs with SA and/or AV nodal–blocking propertiesMetoprolol succinate (long-acting)50 mg QD400 mg QDHypotension, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HFHypotensionReactive airway disease Drugs with SA and/or AV nodal–blocking propertiesNadolol40 mg QD320 mg QD(reduced dosage with renal impairment)Hypotension, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Reactive airway diseaseCardiogenic shockDecompensated HFHypotensionRenal dysfunctionDrugs with SA and/or AV nodal–blocking propertiesPropranolol30–60 mg in divided or single dose with long-acting formulations40–160 mg in divided or single dose with long-acting formulationsHypotension, worsening HF, bronchospasm, bradycardiaAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Reactive airway diseaseDecompensated systolic HFHypotensionDrugs with SA and/or AV nodal–blocking propertiesNondihydropyridine calcium channel antagonistsDiltiazem120 mg daily in divided or single dose with long-acting formulations360 mg daily in divided or single dose with long-acting formulationsHypotension, worsening HF in patients with pre-existing ventricular dysfunction, bradycardia, abnormal liver function studies, acute hepatic injury (rare)AV block greater than first degree or SA node dysfunction (in absence of pacemaker)Hypotension?Decompensated systolic HF?/?severe LV dysfunctionWPW with AF?/?atrial flutterDrugs with SA and/or AV nodal–blocking propertiesDiltiazem is a substrate of CYP3A4 (major) and a moderate CYP3A4 inhibitorApixaban, itraconazole, bosutinib, ceritinib, cilostazol, cyclosporine, everolimus, ibrutinib, idelalisib, ivabradine, lomitapide, olaparib, ranolazine, rifampin, simeprevirVerapamil120 mg daily in divided or single dose with long-acting formulations480 mg daily in divided or single dose with long-acting formulationsHypotension, worsening HF in patients with pre-existing ventricular dysfunction, pulmonary edema in patients with hypertrophic cardiomyopathy, bradycardia, abnormal liver function studiesAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Decompensated systolic HF?/?severe LV dysfunctionHypotension?WPW with AF?/?atrial flutterVerapamil is a moderate CYP3A4 inhibitor and also inhibits P-glycoproteinContraindicated with dofetilide Itraconazole, bosutinib, ceritinib, cilostazol, colchicine, cyclosporine, everolimus, dabigatran, edoxaban, flecainide, ibrutinib, ivabradine, olaparib, ranolazine, rivaroxaban, rifampin, silodosin, simeprevir, rivaroxaban, rifampin, simvastatin, topotecan, trabectedin, vincristine, grapefruit juiceCardiac glycosidesDigoxinLoading: 0.5 mg, with additional 0.125–0.25-mg doses administered at 6–8-h intervals until evidence of adequate effect (maximum dose 8–12 mcg/kg over 24 h)0.25 mg QDMaintenance: 0.125–0.25 mg QD, with dosing based on patient’s age, lean body weight, and renal function and drug interactions; occasionally down to 0.0625 mg in cases of renal impairment (trough serum digoxin level 0.5 to 1 ng/mL)Bradycardia, heart block, anorexia, nausea, vomiting, visual changes and cardiac arrhythmias in cases of digoxin toxicity (associated with levels >2 ng/mL, although symptoms may also occur at lower levels)Renal dysfunctionWPW with AF?/?atrial flutterAV block greater than first degree or SA node dysfunction (in absence of pacemaker)Drugs with SA and/or AV nodal–blocking propertiesReduce dose by 30%–50% when administering with amiodarone and by 50% when administering with dronedaroneMonitor digoxin concentrations with verapamil, clarithromycin, erythromycin, itraconazole, cyclosporine, propafenone, flecainideClass Ic antiarrhythmic agentsFlecainide50 mg every 12 h150 mg every 12 h(PR and QRS intervals should be monitored. May consider monitoring flecainide plasma levels, keeping trough plasma levels below 0.7–1.0 mcg/mL)Atrial flutter with 1:1 AV conduction§, QT prolongation, torsades de pointes, worsening HF, bradycardiaSinus or AV conduction disease (in absence of pacemaker)Cardiogenic shockAvoid in structural heart disease (including ischemic heart disease)Atrial flutter (unless concomitant AV nodal therapy to avoid 1:1 conduction)Brugada syndromeRenal dysfunctionHepatic dysfunctionQT-prolonging drugsAmiodarone, digoxin, ritonavir, saquinavir, tipranavirPropafenone150 mg every 8 h (immediate release);225 mg every 12 h (extended release)300 mg every 8 h (immediate release);425 mg every 12 h (extended release)(PR and QRS interval should be monitored. Consider dosage reduction with hepatic impairment)Atrial flutter with 1:1 AV conduction§, QT prolongation, torsades de pointes, bradycardia, bronchospasmSinus or AV conduction disease (in absence of pacemaker) Cardiogenic shockHypotensionReactive airway disease Avoid in structural heart disease (including ischemic heart disease)Atrial flutter (unless concomitant AV nodal therapy to avoid 1:1 conduction)Brugada syndromeHepatic dysfunctionQT-prolonging drugsDrugs with SA and/or AV nodal–blocking propertiesAmiodarone, ritonavir, saquinavir, tipranavirClass III antiarrhythmic agentsAmiodarone400–600 mg QD in divided doses for 2-4 wk (loading dose); followed by 100–200 mg QD (maintenance dose)Up to 1200 mg QD may be considered in an inpatient monitoring setting (loading dose); up to 200 mg QD maintenance (to minimize long-term adverse effects)Bradycardia, QT prolongation, torsades de pointes (rare), gastrointestinal upset, constipation, hypothyroidism, hyperthyroidism, pulmonary fibrosis, hepatic toxicity, corneal deposits, optic neuritis, peripheral neuropathy, photosensitivity, adult respiratory distress syndrome after cardiac or noncardiac surgery (rare)Sinus or AV conduction disease (in absence of pacemaker) Inflammatory lung diseaseHepatic dysfunctionHypothyroidism, hyperthyroidismPeripheral neuropathyAbnormal gait?/?ataxiaOptic neuritisDrugs with SA and/or AV nodal–blocking propertiesAmiodarone is a substrate of and inhibits p-glycoprotein and CYP2C9 (moderate), CYP2D6 (moderate), and CYP3A4 (weak); amiodarone is a substrate for CYP3A4 (major) and CYP2C8 (major); amiodarone is an inhibitor of OCT2Reduce warfarin dose by 50%, and reduce digoxin dose by 30%–50%Agalsidase alfa, agalsidase beta, azithromycin, bosutinib, ceritinib, colchicine, dabigatran, edoxaban, flecainide, ivabradine, ledipasvir/sofosbuvir, lopinavir, lopinavir/ritonavir, lovastatin, nelfinavir, pazopanib, propafenone, simvastatin, ritonavir, rivaroxaban, saquinavir, sofosbuvir, topotecan, vincristine, grapefruit juiceDofetilide500 mcg every 12 h (if CrCl >60 mL/min)250 mcg every 12 h (if CrCl 40–60 mL/min)125 mcg every 12 h (if CrCl 20 to <40 mL/min)Not recommended if CrCl <20 mL/minAdjust dose for renal function, body size, and ageInitiate for minimum of 3 d in a facility that can provide continuous ECGmonitoring and cardiac resuscitationContraindicated if the baseline QTc interval or QTc >440 ms║ or 500 ms in patients with ventricular conduction abnormalitiesRepeat ECG 2–3 h after administering the first dose to determine QTc; if the QTc increased by >15% compared with baseline or if QTc is >500 ms║ (550 ms in patients with ventricular conduction abnormalities), subsequent dosing should be downtitrated by 50%; at 2–3 h after each subsequent dose, determine QTc (for in-hospital doses 2–5); if at any time after the second dose the QTc is >500 ms║ (550 ms in patients with ventricular conduction abnormalities), dofetilide should be discontinuedQT prolongation, torsades de pointesSevere renal dysfunction (contraindicated if CrCl <20 mL/min)Prolonged QT History of torsades de pointesConcomitant use of hydrochlorothiazide, cimetidine, dolutegravir, itraconazole, ketoconazole, megestrol, trimethoprim, prochlorperazine trimethoprim/sulfamethoxazole or verapamil, contraindicatedAvoid other QT-prolonging drugsSotalol40–80 mg every 12 h (Patients initiated or reinitiated on sotalol should be placed in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring for a minimum of 3 d. Contraindicated if the QTc║ interval is >450 ms. CrCl should be calculated before dosing. If CrCl >60 mL/min, then dosing frequency is twice daily. If CrCl 40-60 mL/min, dosing interval is every 24 h. If CrCl <40 mL/min, should not be used.)160 mg every 12 h(During initiation and titration, the QT interval should be monitored 2–4 h after each dose. If the QT interval prolongs to ≥500 ms, the dose must be reduced or the drug discontinued.)QT prolongation, torsades de pointes, bradycardia, bronchospasmProlonged QTRenal dysfunctionHypokalemiaDiuretic therapyAvoid other QT-prolonging drugsSinus or AV nodal dysfunction (in absence of pacemaker)Decompensated systolic HFCardiogenic shockReactive airway diseaseDrugs with SA and/or AV–nodal blocking propertiesMiscellaneousIvabradine5 mg BID7.5 mg BIDPhosphenes, AFConcomitant drugs that can exacerbate bradycardiaContraindicated in decompensated HFContraindicated if BP <90/50 mm?HgContraindicated in severe hepatic impairmentHypertensionIvabradine is a substrate of CYP3A4 (major)Avoid use with concomitant strong CYP3A4 inhibitors (boceprevir, clarithromycin, indinavir, itraconazole, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, telaprevir, posaconazole, voriconazole)Avoid use with strong CYP3A4 inducers (carbamazepine, phenytoin, rifampin, St. John’s wort)Avoid use with diltiazem, verapamil, grapefruit juiceNote: For this reference table, drugs are presented in alphabetical order within the drug classes, not by COR and LOE. *When 1 drug is used in combination with other drugs, appropriate dosing adjustments should be made with consideration of at least additive effects during dosage titration. All potential drug–drug interactions and adverse reactions are not included in this list. For a more detailed list of drug interactions and adverse responses, clinicians should consult additional resources; for example, may be consulted for potential prolongation of the QT interval. §Recommended given in conjunction with a beta blocker or nondihydropyridine calcium channel antagonist. ║QTc calculation used the Bazett’s Formula in most clinical studies.AF indicates atrial fibrillation; AV, atrioventricular; BID, twice daily; BP, blood pressure; CrCl, creatinine clearance; ECG, electrocardiogram/electrocardiographic; HF, heart failure; INR, international normalized ratio; LV, left ventricular; QD, once daily; QID, 4 times a day; QTc, corrected QT interval; SA, sinoatrial; SVT, supraventricular tachycardia; TID, 3 times a day; and WPW, Wolff-Parkinson-White.Appendix 3. Success and Complication Rates for Ablation of SVT* ArrhythmiaAcute SuccessRecurrence RateMajor ComplicationsReferencesCommon SVTsAVNRT96%–97% PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (55, 59) 5% PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (59)Overall 3% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PPM 0.7% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)Death 0% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwZWN0b3I8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwZWN0b3I8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (55, 59) AVRT?/?accessory pathway93% PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (55, 59)8% PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (59)Overall 2.8% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PPM 0.3% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)Death 0.1% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)Tamponade 0.4% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwZWN0b3I8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPlNwZWN0b3I8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (55, 59)CTI-dependent atrial flutter97% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55) 10.6% atrial flutter ADDIN REFMGR.CITE <Refman><Cite><Author>Perez</Author><Year>2009</Year><RecNum>517</RecNum><IDText>Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>517</Ref_ID><Title_Primary>Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis</Title_Primary><Authors_Primary>Perez,F.J.</Authors_Primary><Authors_Primary>Schubert,C.M.</Authors_Primary><Authors_Primary>Parvez,B.</Authors_Primary><Authors_Primary>Pathak,V.</Authors_Primary><Authors_Primary>Ellenbogen,K.A.</Authors_Primary><Authors_Primary>Wood,M.A.</Authors_Primary><Date_Primary>2009/8</Date_Primary><Keywords>analysis</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Disease</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>methods</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Recurrence</Keywords><Keywords>surgery</Keywords><Keywords>Time</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Tricuspid Valve</Keywords><Reprint>Not in File</Reprint><Start_Page>393</Start_Page><End_Page>401</End_Page><Periodical>Circ Arrhythm.Electrophysiol.</Periodical><Volume>2</Volume><Issue>4</Issue><ISSN_ISBN>1941-3084</ISSN_ISBN><Misc_3>CIRCEP.109.871665;10.1161/CIRCEP.109.871665</Misc_3><Address>Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0053, USA</Address><Web_URL>PM:19808495</Web_URL><ZZ_JournalFull><f name="System">Circulation.Arrhythmia and electrophysiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Circ Arrhythm.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(395), 33% atrial fibrillation ADDIN REFMGR.CITE <Refman><Cite><Author>Perez</Author><Year>2009</Year><RecNum>517</RecNum><IDText>Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>517</Ref_ID><Title_Primary>Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis</Title_Primary><Authors_Primary>Perez,F.J.</Authors_Primary><Authors_Primary>Schubert,C.M.</Authors_Primary><Authors_Primary>Parvez,B.</Authors_Primary><Authors_Primary>Pathak,V.</Authors_Primary><Authors_Primary>Ellenbogen,K.A.</Authors_Primary><Authors_Primary>Wood,M.A.</Authors_Primary><Date_Primary>2009/8</Date_Primary><Keywords>analysis</Keywords><Keywords>Atrial Fibrillation</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Cardiology</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>Disease</Keywords><Keywords>Heart</Keywords><Keywords>Humans</Keywords><Keywords>Incidence</Keywords><Keywords>methods</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>physiopathology</Keywords><Keywords>Quality of Life</Keywords><Keywords>Recurrence</Keywords><Keywords>surgery</Keywords><Keywords>Time</Keywords><Keywords>Treatment Outcome</Keywords><Keywords>Tricuspid Valve</Keywords><Reprint>Not in File</Reprint><Start_Page>393</Start_Page><End_Page>401</End_Page><Periodical>Circ Arrhythm.Electrophysiol.</Periodical><Volume>2</Volume><Issue>4</Issue><ISSN_ISBN>1941-3084</ISSN_ISBN><Misc_3>CIRCEP.109.871665;10.1161/CIRCEP.109.871665</Misc_3><Address>Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0053, USA</Address><Web_URL>PM:19808495</Web_URL><ZZ_JournalFull><f name="System">Circulation.Arrhythmia and electrophysiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Circ Arrhythm.Electrophysiol.</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(395)Overall 0.5% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PPM 0.2% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)Pericardial effusion 0.3% ADDIN REFMGR.CITE <Refman><Cite><Author>Spector</Author><Year>2009</Year><RecNum>158</RecNum><IDText>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</IDText><MDL Ref_Type="Journal"><Ref_Type>Journal</Ref_Type><Ref_ID>158</Ref_ID><Title_Primary>Meta-analysis of ablation of atrial flutter and supraventricular tachycardia</Title_Primary><Authors_Primary>Spector,P.</Authors_Primary><Authors_Primary>Reynolds,M.R.</Authors_Primary><Authors_Primary>Calkins,H.</Authors_Primary><Authors_Primary>Sondhi,M.</Authors_Primary><Authors_Primary>Xu,Y.</Authors_Primary><Authors_Primary>Martin,A.</Authors_Primary><Authors_Primary>Williams,C.J.</Authors_Primary><Authors_Primary>Sledge,I.</Authors_Primary><Date_Primary>2009/9/1</Date_Primary><Keywords>Adult</Keywords><Keywords>Atrial Flutter</Keywords><Keywords>Catheter Ablation</Keywords><Keywords>complications</Keywords><Keywords>Humans</Keywords><Keywords>Medicine</Keywords><Keywords>mortality</Keywords><Keywords>Patients</Keywords><Keywords>Recurrence</Keywords><Keywords>Research</Keywords><Keywords>Safety</Keywords><Keywords>surgery</Keywords><Keywords>Tachycardia</Keywords><Keywords>Tachycardia,Atrioventricular Nodal Reentry</Keywords><Keywords>Treatment Outcome</Keywords><Reprint>Not in File</Reprint><Start_Page>671</Start_Page><End_Page>677</End_Page><Periodical>Am J Cardiol</Periodical><Volume>104</Volume><Issue>5</Issue><ISSN_ISBN>1879-1913</ISSN_ISBN><Misc_3>S0002-9149(09)01008-X;10.1016/j.amjcard.2009.04.040</Misc_3><Address>University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, Vermont, USA. Peter.Spector@</Address><Web_URL>PM:19699343</Web_URL><ZZ_JournalFull><f name="System">The American journal of cardiology</f></ZZ_JournalFull><ZZ_JournalStdAbbrev><f name="System">Am J Cardiol</f></ZZ_JournalStdAbbrev><ZZ_WorkformID>1</ZZ_WorkformID></MDL></Cite></Refman>(55)PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNhbGtpbnM8L0F1dGhvcj48WWVhcj4xOTk5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (55, 59, 395)Less common SVTsFocal AT80%–100%4%–27%<1%–2% PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIExvbWEtT3NvcmlvPC9BdXRob3I+PFllYXI+MjAxMzwv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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIExvbWEtT3NvcmlvPC9BdXRob3I+PFllYXI+MjAxMzwv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ADDIN EN.CITE.DATA (89, 93, 97, 99, 105, 106, 396, 397)JT82%–85%0–18%0–18% CHB (overall complications N/A)PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS
ZWNOdW0+OTU8L1JlY051bT48SURUZXh0PlBlZGlhdHJpYyBub25wb3N0LW9wZXJhdGl2ZSBqdW5j
dGlvbmFsIGVjdG9waWMgdGFjaHljYXJkaWEgbWVkaWNhbCBtYW5hZ2VtZW50IGFuZCBpbnRlcnZl
bnRpb25hbCB0aGVyYXBpZXM8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3VybmFsIj48UmVmX1R5
cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD45NTwvUmVmX0lEPjxUaXRsZV9QcmltYXJ5PlBl
ZGlhdHJpYyBub25wb3N0LW9wZXJhdGl2ZSBqdW5jdGlvbmFsIGVjdG9waWMgdGFjaHljYXJkaWEg
bWVkaWNhbCBtYW5hZ2VtZW50IGFuZCBpbnRlcnZlbnRpb25hbCB0aGVyYXBpZXM8L1RpdGxlX1By
aW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Db2xsaW5zLEsuSy48L0F1dGhvcnNfUHJpbWFyeT48QXV0
aG9yc19QcmltYXJ5PlZhbiBIYXJlLEcuRi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Qcmlt
YXJ5PktlcnRlc3osTi5KLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGF3LEku
SC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkJhci1Db2hlbixZLjwvQXV0aG9y
c19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+RHViaW4sQS5NLjwvQXV0aG9yc19QcmltYXJ5PjxB
dXRob3JzX1ByaW1hcnk+RXRoZXJpZGdlLFMuUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PkJlcnVsLEMuSS48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkF2YXJp
LEouTi48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlR1emN1LFYuPC9BdXRob3Jz
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TcmVlcmFtLE4uPC9BdXRob3JzX1ByaW1hcnk+PEF1
dGhvcnNfUHJpbWFyeT5TY2hhZmZlcixNLlMuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJp
bWFyeT5Gb3VybmllcixBLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2FuYXRh
bmksUy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PlNueWRlcixDLlMuPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5TbWl0aCxSLlQuLEpyLjwvQXV0aG9yc19Qcmlt
YXJ5PjxBdXRob3JzX1ByaW1hcnk+QXJhYmlhLEwuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNf
UHJpbWFyeT5IYW1pbHRvbixSLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+Q2h1
bixULjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGliZXJtYW4sTC48L0F1dGhv
cnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pktha2F2YW5kLEIuPC9BdXRob3JzX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5QYXVsLFQuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFy
eT5UYW5lbCxSLkUuPC9BdXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4yMDA5LzIvMjQ8L0Rh
dGVfUHJpbWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFtaW9k
YXJvbmU8L0tleXdvcmRzPjxLZXl3b3Jkcz5BbnRpLUFycmh5dGhtaWEgQWdlbnRzPC9LZXl3b3Jk
cz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdvcmRzPjxLZXl3b3Jkcz5DaGlsZDwv
S2V5d29yZHM+PEtleXdvcmRzPkNoaWxkLFByZXNjaG9vbDwvS2V5d29yZHM+PEtleXdvcmRzPkZl
bWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZmFu
dDwvS2V5d29yZHM+PEtleXdvcmRzPkluZmFudCxOZXdib3JuPC9LZXl3b3Jkcz48S2V5d29yZHM+
TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRzPjxLZXl3b3Jkcz5tb3J0
YWxpdHk8L0tleXdvcmRzPjxLZXl3b3Jkcz5QYWNlbWFrZXIsQXJ0aWZpY2lhbDwvS2V5d29yZHM+
PEtleXdvcmRzPlRhY2h5Y2FyZGlhPC9LZXl3b3Jkcz48S2V5d29yZHM+VGFjaHljYXJkaWEsRWN0
b3BpYyBKdW5jdGlvbmFsPC9LZXl3b3Jkcz48S2V5d29yZHM+dGhlcmFwZXV0aWMgdXNlPC9LZXl3
b3Jkcz48S2V5d29yZHM+dGhlcmFweTwvS2V5d29yZHM+PFJlcHJpbnQ+Tm90IGluIEZpbGU8L1Jl
cHJpbnQ+PFN0YXJ0X1BhZ2U+NjkwPC9TdGFydF9QYWdlPjxFbmRfUGFnZT42OTc8L0VuZF9QYWdl
PjxQZXJpb2RpY2FsPkogQW0gQ29sbCBDYXJkaW9sPC9QZXJpb2RpY2FsPjxWb2x1bWU+NTM8L1Zv
bHVtZT48SXNzdWU+ODwvSXNzdWU+PElTU05fSVNCTj4xNTU4LTM1OTc8L0lTU05fSVNCTj48TWlz
Y18zPlMwNzM1LTEwOTcoMDgpMDM4ODUtMDsxMC4xMDE2L2ouamFjYy4yMDA4LjExLjAxOTwvTWlz
Y18zPjxBZGRyZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcywgRGl2aXNpb24gb2YgQ2FyZGlv
bG9neSwgVGhlIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCwgMTMxMjMgRS4gMTZ0aCBBdmVudWUs
IEF1cm9yYSwgQ08gODAwNDUsIFVTQS4gQ29sbGlucy5rYXRocnluQHRjaGRlbi5vcmc8L0FkZHJl
c3M+PFdlYl9VUkw+UE06MTkyMzI5MDI8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9
IlN5c3RlbSI+Sm91cm5hbCBvZiB0aGUgQW1lcmljYW4gQ29sbGVnZSBvZiBDYXJkaW9sb2d5PC9m
PjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0iU3lzdGVtIj5K
IEFtIENvbGwgQ2FyZGlvbDwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpaX1dvcmtmb3JtSUQ+
MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYW1kYW48L0F1dGhv
cj48WWVhcj4xOTk2PC9ZZWFyPjxSZWNOdW0+OTc8L1JlY051bT48SURUZXh0PlNlbGVjdGl2ZSBj
YXRoZXRlciBhYmxhdGlvbiBvZiB0aGUgdGFjaHljYXJkaWEgZm9jdXMgaW4gcGF0aWVudHMgd2l0
aCBub25yZWVudHJhbnQganVuY3Rpb25hbCB0YWNoeWNhcmRpYTwvSURUZXh0PjxNREwgUmVmX1R5
cGU9IkpvdXJuYWwiPjxSZWZfVHlwZT5Kb3VybmFsPC9SZWZfVHlwZT48UmVmX0lEPjk3PC9SZWZf
SUQ+PFRpdGxlX1ByaW1hcnk+U2VsZWN0aXZlIGNhdGhldGVyIGFibGF0aW9uIG9mIHRoZSB0YWNo
eWNhcmRpYSBmb2N1cyBpbiBwYXRpZW50cyB3aXRoIG5vbnJlZW50cmFudCBqdW5jdGlvbmFsIHRh
Y2h5Y2FyZGlhPC9UaXRsZV9QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+SGFtZGFuLE0uPC9BdXRo
b3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5WYW4gSGFyZSxHLkYuPC9BdXRob3JzX1ByaW1h
cnk+PEF1dGhvcnNfUHJpbWFyeT5GaXNoZXIsVy48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19Q
cmltYXJ5PkdvbnphbGV6LFIuPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5Eb3Jv
c3RrYXIsUC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkxlZSxSLjwvQXV0aG9y
c19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+TGVzaCxNLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRo
b3JzX1ByaW1hcnk+U2F4b24sTC48L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5Pkth
bG1hbixKLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2NoZWlubWFuLE0uPC9B
dXRob3JzX1ByaW1hcnk+PERhdGVfUHJpbWFyeT4xOTk2LzEyLzE8L0RhdGVfUHJpbWFyeT48S2V5
d29yZHM+QWRvbGVzY2VudDwvS2V5d29yZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5
d29yZHM+QWdlZDwvS2V5d29yZHM+PEtleXdvcmRzPkF0cmlvdmVudHJpY3VsYXIgQmxvY2s8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5BdHJpb3ZlbnRyaWN1bGFyIE5vZGU8L0tleXdvcmRzPjxLZXl3b3Jk
cz5DYXRoZXRlciBBYmxhdGlvbjwvS2V5d29yZHM+PEtleXdvcmRzPkNoaWxkPC9LZXl3b3Jkcz48
S2V5d29yZHM+Q29ob3J0IFN0dWRpZXM8L0tleXdvcmRzPjxLZXl3b3Jkcz5kaWFnbm9zaXM8L0tl
eXdvcmRzPjxLZXl3b3Jkcz5FbGVjdHJvY2FyZGlvZ3JhcGh5LEFtYnVsYXRvcnk8L0tleXdvcmRz
PjxLZXl3b3Jkcz5GZW1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5Gb2xsb3ctVXAgU3R1ZGllczwv
S2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRzPkluZmFudDwvS2V5
d29yZHM+PEtleXdvcmRzPk1hbGU8L0tleXdvcmRzPjxLZXl3b3Jkcz5NaWRkbGUgQWdlZDwvS2V5
d29yZHM+PEtleXdvcmRzPk5ldXJhbCBDb25kdWN0aW9uPC9LZXl3b3Jkcz48S2V5d29yZHM+cGh5
c2lvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtl
eXdvcmRzPlJlY3VycmVuY2U8L0tleXdvcmRzPjxLZXl3b3Jkcz5zdXJnZXJ5PC9LZXl3b3Jkcz48
S2V5d29yZHM+VGFjaHljYXJkaWE8L0tleXdvcmRzPjxLZXl3b3Jkcz5UYWNoeWNhcmRpYSxFY3Rv
cGljIEp1bmN0aW9uYWw8L0tleXdvcmRzPjxSZXByaW50Pk5vdCBpbiBGaWxlPC9SZXByaW50PjxT
dGFydF9QYWdlPjEyOTI8L1N0YXJ0X1BhZ2U+PEVuZF9QYWdlPjEyOTc8L0VuZF9QYWdlPjxQZXJp
b2RpY2FsPkFtIEogQ2FyZGlvbDwvUGVyaW9kaWNhbD48Vm9sdW1lPjc4PC9Wb2x1bWU+PElzc3Vl
PjExPC9Jc3N1ZT48SVNTTl9JU0JOPjAwMDItOTE0OTwvSVNTTl9JU0JOPjxNaXNjXzM+UzAwMDI5
MTQ5OTYwMDYxNjk8L01pc2NfMz48QWRkcmVzcz5Vbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIFNh
biBGcmFuY2lzY28gOTQxNDMsIFVTQTwvQWRkcmVzcz48V2ViX1VSTD5QTTo4OTYwNTk1PC9XZWJf
VVJMPjxaWl9Kb3VybmFsRnVsbD48ZiBuYW1lPSJTeXN0ZW0iPlRoZSBBbWVyaWNhbiBqb3VybmFs
IG9mIGNhcmRpb2xvZ3k8L2Y+PC9aWl9Kb3VybmFsRnVsbD48WlpfSm91cm5hbFN0ZEFiYnJldj48
ZiBuYW1lPSJTeXN0ZW0iPkFtIEogQ2FyZGlvbDwvZj48L1paX0pvdXJuYWxTdGRBYmJyZXY+PFpa
X1dvcmtmb3JtSUQ+MTwvWlpfV29ya2Zvcm1JRD48L01ETD48L0NpdGU+PENpdGU+PEF1dGhvcj5M
YXc8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNOdW0+OTg8L1JlY051bT48SURUZXh0PlRy
YW5zY2F0aGV0ZXIgY3J5b3RoZXJtYWwgYWJsYXRpb24gb2YganVuY3Rpb25hbCBlY3RvcGljIHRh
Y2h5Y2FyZGlhIGluIHRoZSBub3JtYWwgaGVhcnQ8L0lEVGV4dD48TURMIFJlZl9UeXBlPSJKb3Vy
bmFsIj48UmVmX1R5cGU+Sm91cm5hbDwvUmVmX1R5cGU+PFJlZl9JRD45ODwvUmVmX0lEPjxUaXRs
ZV9QcmltYXJ5PlRyYW5zY2F0aGV0ZXIgY3J5b3RoZXJtYWwgYWJsYXRpb24gb2YganVuY3Rpb25h
bCBlY3RvcGljIHRhY2h5Y2FyZGlhIGluIHRoZSBub3JtYWwgaGVhcnQ8L1RpdGxlX1ByaW1hcnk+
PEF1dGhvcnNfUHJpbWFyeT5MYXcsSS5ILjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1h
cnk+Vm9uIEJlcmdlbixOLkguPC9BdXRob3JzX1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5HaW5n
ZXJpY2gsSi5DLjwvQXV0aG9yc19QcmltYXJ5PjxBdXRob3JzX1ByaW1hcnk+U2FhcmVsLEUuVi48
L0F1dGhvcnNfUHJpbWFyeT48QXV0aG9yc19QcmltYXJ5PkZpc2NoYmFjaCxQLlMuPC9BdXRob3Jz
X1ByaW1hcnk+PEF1dGhvcnNfUHJpbWFyeT5EaWNrLE0uPC9BdXRob3JzX1ByaW1hcnk+PERhdGVf
UHJpbWFyeT4yMDA2Lzg8L0RhdGVfUHJpbWFyeT48S2V5d29yZHM+QWRvbGVzY2VudDwvS2V5d29y
ZHM+PEtleXdvcmRzPkFkdWx0PC9LZXl3b3Jkcz48S2V5d29yZHM+Qm9keSBTdXJmYWNlIFBvdGVu
dGlhbCBNYXBwaW5nPC9LZXl3b3Jkcz48S2V5d29yZHM+Q2F0aGV0ZXIgQWJsYXRpb248L0tleXdv
cmRzPjxLZXl3b3Jkcz5DaGlsZDwvS2V5d29yZHM+PEtleXdvcmRzPkNyeW9zdXJnZXJ5PC9LZXl3
b3Jkcz48S2V5d29yZHM+RWxlY3Ryb2NhcmRpb2dyYXBoeSxBbWJ1bGF0b3J5PC9LZXl3b3Jkcz48
S2V5d29yZHM+RWxlY3Ryb3BoeXNpb2xvZ2ljIFRlY2huaXF1ZXMsQ2FyZGlhYzwvS2V5d29yZHM+
PEtleXdvcmRzPkZlbWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPkZvbGxvdy1VcCBTdHVkaWVzPC9L
ZXl3b3Jkcz48S2V5d29yZHM+SGVhcnQ8L0tleXdvcmRzPjxLZXl3b3Jkcz5IZWFydCBDb25kdWN0
aW9uIFN5c3RlbTwvS2V5d29yZHM+PEtleXdvcmRzPkh1bWFuczwvS2V5d29yZHM+PEtleXdvcmRz
PkltYWdpbmcsVGhyZWUtRGltZW5zaW9uYWw8L0tleXdvcmRzPjxLZXl3b3Jkcz5Jb3dhPC9LZXl3
b3Jkcz48S2V5d29yZHM+TWFsZTwvS2V5d29yZHM+PEtleXdvcmRzPm1ldGhvZHM8L0tleXdvcmRz
PjxLZXl3b3Jkcz5NaWNoaWdhbjwvS2V5d29yZHM+PEtleXdvcmRzPnBhdGhvbG9neTwvS2V5d29y
ZHM+PEtleXdvcmRzPnBoeXNpb3BhdGhvbG9neTwvS2V5d29yZHM+PEtleXdvcmRzPlJldHJvc3Bl
Y3RpdmUgU3R1ZGllczwvS2V5d29yZHM+PEtleXdvcmRzPnN1cmdlcnk8L0tleXdvcmRzPjxLZXl3
b3Jkcz5UYWNoeWNhcmRpYTwvS2V5d29yZHM+PEtleXdvcmRzPlRhY2h5Y2FyZGlhLEVjdG9waWMg
SnVuY3Rpb25hbDwvS2V5d29yZHM+PEtleXdvcmRzPlRyZWF0bWVudCBPdXRjb21lPC9LZXl3b3Jk
cz48UmVwcmludD5Ob3QgaW4gRmlsZTwvUmVwcmludD48U3RhcnRfUGFnZT45MDM8L1N0YXJ0X1Bh
Z2U+PEVuZF9QYWdlPjkwNzwvRW5kX1BhZ2U+PFBlcmlvZGljYWw+SGVhcnQgUmh5dGhtPC9QZXJp
b2RpY2FsPjxWb2x1bWU+MzwvVm9sdW1lPjxJc3N1ZT44PC9Jc3N1ZT48SVNTTl9JU0JOPjE1NDct
NTI3MTwvSVNTTl9JU0JOPjxNaXNjXzM+UzE1NDctNTI3MSgwNikwMTQ4MC05OzEwLjEwMTYvai5o
cnRobS4yMDA2LjA0LjAyNjwvTWlzY18zPjxBZGRyZXNzPkNoaWxkcmVuJmFwb3M7cyBIb3NwaXRh
bCBvZiBJb3dhLCBVbml2ZXJzaXR5IG9mIElvd2EgSG9zcGl0YWxzIGFuZCBDbGluaWNzLCBJb3dh
IENpdHksIDU1MjQyLTEwODMsIFVTQS4gaWFuLWxhd0B1aW93YS5lZHU8L0FkZHJlc3M+PFdlYl9V
Ukw+UE06MTY4NzY3Mzg8L1dlYl9VUkw+PFpaX0pvdXJuYWxGdWxsPjxmIG5hbWU9IlN5c3RlbSI+
SGVhcnQgcmh5dGhtIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEhlYXJ0IFJoeXRobSBT
b2NpZXR5PC9mPjwvWlpfSm91cm5hbEZ1bGw+PFpaX0pvdXJuYWxTdGRBYmJyZXY+PGYgbmFtZT0i
U3lzdGVtIj5IZWFydCBSaHl0aG08L2Y+PC9aWl9Kb3VybmFsU3RkQWJicmV2PjxaWl9Xb3JrZm9y
bUlEPjE8L1paX1dvcmtmb3JtSUQ+PC9NREw+PC9DaXRlPjwvUmVmbWFuPm==
ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPkNvbGxpbnM8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (233, 234, 269)Non–CTI-dependent atrial flutter73%–100%7%–53%0–7%PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIExvbWEtT3NvcmlvPC9BdXRob3I+PFllYXI+MjAxMzwv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ADDIN REFMGR.CITE PFJlZm1hbj48Q2l0ZT48QXV0aG9yPmRlIExvbWEtT3NvcmlvPC9BdXRob3I+PFllYXI+MjAxMzwv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ADDIN EN.CITE.DATA (106, 211, 213, 215, 216, 218, 219, 221, 398)*Data in this table are derived from multiple observational studies and registries, and as such may not always reflect current practice.AT indicates atrial tachycardia; AVNRT, atrioventricular nodal reentrant tachycardia; AVRT, atrioventricular reentrant tachycardia; CHB, complete heart block; CTI, cavotricuspid isthmus; JT, junctional tachycardia; N/A, not available; PPM, permanent pacemaker; and SVT, supraventricular tachycardia. ADDIN REFMGR.REFLIST References1. Sganzerla P, Fabbiocchi F, Grazi S, et al. Electrophysiologic and haemodynamic correlates in supraventricular tachycardia. Eur Heart J. 1989;10:32-9.2. Bhandari AK, Anderson JL, Gilbert EM, et al. Correlation of symptoms with occurrence of paroxysmal supraventricular tachycardia or atrial fibrillation: a transtelephonic monitoring study. The Flecainide Supraventricular Tachycardia Study Group. Am Heart J. 1992;124:381-6.3. Leitch JW, Klein GJ, Yee R, et al. Syncope associated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response? Circulation. 1992;85:1064-71.4. Lee SH, Chen SA, Wu TJ, et al. Effects of pregnancy on first onset and symptoms of paroxysmal supraventricular tachycardia. Am J Cardiol. 1995;76:675-8.5. Drago F, Turchetta A, Calzolari A, et al. Reciprocating supraventricular tachycardia in children: low rate at rest as a major factor related to propensity to syncope during exercise. Am Heart J. 1996;132:280-5.6. Goyal R, Zivin A, Souza J, et al. Comparison of the ages of tachycardia onset in patients with atrioventricular nodal reentrant tachycardia and accessory pathway-mediated tachycardia. Am Heart J. 1996;132:765-7.7. Abe H, Nagatomo T, Kobayashi H, et al. Neurohumoral and hemodynamic mechanisms of diuresis during atrioventricular nodal reentrant tachycardia. Pacing Clin Electrophysiol. 1997;20:2783-8.8. Lessmeier TJ, Gamperling D, Johnson-Liddon V, et al. Unrecognized paroxysmal supraventricular tachycardia. Potential for misdiagnosis as panic disorder. Arch Intern Med. 1997;157:537-43.9. Kalusche D, Ott P, Arentz T, et al. AV nodal re-entry tachycardia in elderly patients: clinical presentation and results of radiofrequency catheter ablation therapy. Coron Artery Dis. 1998;9:359-63.10. Orejarena LA, Vidaillet H, Jr., DeStefano F, et al. Paroxysmal supraventricular tachycardia in the general population. J Am Coll Cardiol. 1998;31:150-7.11. Erdogan A, Schulte B, Carlsson J, et al. [Clinical characteristics of patients with AV-nodal reentrant tachycardia (AVNRT): modification by high frequency catheter ablation. Study of 748 patients after high frequency catheter ablation]. Med Klin (Munich ). 2001;96:708-12.12. Fitzsimmons PJ, McWhirter PD, Peterson DW, et al. The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years. Am Heart J. 2001;142:530-6.13. Hamdan MH, Zagrodzky JD, Page RL, et al. Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response. Circulation. 2001;103:96-101.14. Razavi M, Luria DM, Jahangir A, et al. Acute blood pressure changes after the onset of atrioventricular nodal reentrant tachycardia: a time-course analysis. J Cardiovasc Electrophysiol. 2005;16:1037-40.15. Walfridsson U, Walfridsson H. The impact of supraventricular tachycardias on driving ability in patients referred for radiofrequency catheter ablation. Pacing Clin Electrophysiol. 2005;28:191-5.16. Drago F, Grutter G, Silvetti MS, et al. Atrioventricular nodal reentrant tachycardia in children. Pediatr Cardiol. 2006;27:454-9.17. Gonzalez-Torrecilla E, Almendral J, Arenal A, et al. Combined evaluation of bedside clinical variables and the electrocardiogram for the differential diagnosis of paroxysmal atrioventricular reciprocating tachycardias in patients without pre-excitation. J Am Coll Cardiol. 2009;53:2353-8.18. Laurent G, Leong-Poi H, Mangat I, et al. Influence of ventriculoatrial timing on hemodynamics and symptoms during supraventricular tachycardia. J Cardiovasc Electrophysiol. 2009;20:176-81.19. Walfridsson U, Stromberg A, Janzon M, et al. Wolff-Parkinson-White syndrome and atrioventricular nodal re-entry tachycardia in a Swedish population: consequences on health-related quality of life. Pacing Clin Electrophysiol. 2009;32:1299-306.20. Kesek M, Ronn F, Tollefsen T, et al. Symptomatic improvement after catheter ablation of supraventricular tachycardia measured by the arrhythmia-specific questionnaire U22. Ups J Med Sci. 2011;116:52-9.21. Cain N, Irving C, Webber S, et al. Natural history of Wolff-Parkinson-White syndrome diagnosed in childhood. Am J Cardiol. 2013;112:961-5.22. Maryniak A, Bielawska A, Bieganowska K, et al. Does atrioventricular reentry tachycardia (AVRT) or atrioventricular nodal reentry tachycardia (AVNRT) in children affect their cognitive and emotional development? Pediatr Cardiol. 2013;34:893-7.23. Mauritson DR, Winniford MD, Walker WS, et al. Oral verapamil for paroxysmal supraventricular tachycardia: a long-term, double-blind randomized trial. Ann Intern Med. 1982;96:409-12.24. Winniford MD, Fulton KL, Hillis LD. Long-term therapy of paroxysmal supraventricular tachycardia: a randomized, double-blind comparison of digoxin, propranolol and verapamil. Am J Cardiol. 1984;54:1138-9.25. Anderson S, Blanski L, Byrd RC, et al. Comparison of the efficacy and safety of esmolol, a short-acting beta blocker, with placebo in the treatment of supraventricular tachyarrhythmias. The Esmolol vs Placebo Multicenter Study Group. Am Heart J. 1986;111:42-8.26. Henthorn RW, Waldo AL, Anderson JL, et al. Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group. Circulation. 1991;83:119-25.27. Pritchett EL, DaTorre SD, Platt ML, et al. Flecainide acetate treatment of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation: dose-response studies. The Flecainide Supraventricular Tachycardia Study Group. J Am Coll Cardiol. 1991;17:297-303.28. Pritchett EL, McCarthy EA, Wilkinson WE. Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy. Ann Intern Med. 1991;114:539-44.29. Anderson JL, Platt ML, Guarnieri T, et al. Flecainide acetate for paroxysmal supraventricular tachyarrhythmias. The Flecainide Supraventricular Tachycardia Study Group. Am J Cardiol. 1994;74:578-84.30. Chimienti M, Cullen MT, Jr., Casadei G. Safety of flecainide versus propafenone for the long-term management of symptomatic paroxysmal supraventricular tachyarrhythmias. Report from the Flecainide and Propafenone Italian Study (FAPIS) Group. Eur Heart J. 1995;16:1943-51.31. A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group. Circulation. 1995;92:2550-7.32. Dorian P, Naccarelli GV, Coumel P, et al. A randomized comparison of flecainide versus verapamil in paroxysmal supraventricular tachycardia. The Flecainide Multicenter Investigators Group. Am J Cardiol. 1996;77:89A-95A.33. Wanless RS, Anderson K, Joy M, et al. Multicenter comparative study of the efficacy and safety of sotalol in the prophylactic treatment of patients with paroxysmal supraventricular tachyarrhythmias. Am Heart J. 1997;133:441-6.34. Lim SH, Anantharaman V, Teo WS, et al. Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage. Ann Emerg Med. 1998;31:30-5.35. Gupta A, Naik A, Vora A, et al. Comparison of efficacy of intravenous diltiazem and esmolol in terminating supraventricular tachycardia. J Assoc Physicians India. 1999;47:969-72.36. Alboni P, Tomasi C, Menozzi C, et al. Efficacy and safety of out-of-hospital self-administered single-dose oral drug treatment in the management of infrequent, well-tolerated paroxysmal supraventricular tachycardia. J Am Coll Cardiol. 2001;37:548-53.37. Tendera M, Wnuk-Wojnar AM, Kulakowski P, et al. Efficacy and safety of dofetilide in the prevention of symptomatic episodes of paroxysmal supraventricular tachycardia: a 6-month double-blind comparison with propafenone and placebo. Am Heart J. 2001;142:93-8.38. Lim SH, Anantharaman V, Teo WS, et al. Slow infusion of calcium channel blockers compared with intravenous adenosine in the emergency treatment of supraventricular tachycardia. Resuscitation. 2009;80:523-8.39. Smith GD, Dyson K, Taylor D, et al. Effectiveness of the Valsalva Manoeuvre for reversion of supraventricular tachycardia. Cochrane Database Syst Rev. 2013;3:CD009502.40. Mehta D, Wafa S, Ward DE, et al. Relative efficacy of various physical manoeuvres in the termination of junctional tachycardia. Lancet. 1988;1:1181-5.41. Wen ZC, Chen SA, Tai CT, et al. Electrophysiological mechanisms and determinants of vagal maneuvers for termination of paroxysmal supraventricular tachycardia. Circulation. 1998;98:2716-23.42. Waxman MB, Wald RW, Sharma AD, et al. Vagal techniques for termination of paroxysmal supraventricular tachycardia. Am J Cardiol. 1980;46:655-64.43. Rankin AC, Oldroyd KG, Chong E, et al. Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias. Br Heart J. 1989;62:195-203.44. Cairns CB, Niemann JT. Intravenous adenosine in the emergency department management of paroxysmal supraventricular tachycardia. Ann Emerg Med. 1991;20:717-21.45. McCabe JL, Adhar GC, Menegazzi JJ, et al. Intravenous adenosine in the prehospital treatment of paroxysmal supraventricular tachycardia. Ann Emerg Med. 1992;21:358-61.46. Gausche M, Persse DE, Sugarman T, et al. Adenosine for the prehospital treatment of paroxysmal supraventricular tachycardia. Ann Emerg Med. 1994;24:183-9.47. Madsen CD, Pointer JE, Lynch TG. A comparison of adenosine and verapamil for the treatment of supraventricular tachycardia in the prehospital setting. Ann Emerg Med. 1995;25:649-55.48. Brady WJ, Jr., DeBehnke DJ, Wickman LL, et al. Treatment of out-of-hospital supraventricular tachycardia: adenosine vs verapamil. Acad Emerg Med. 1996;3:574-85.49. Luber S, Brady WJ, Joyce T, et al. Paroxysmal supraventricular tachycardia: outcome after ED care. Am J Emerg Med. 2001;19:40-2.50. Roth A, Elkayam I, Shapira I, et al. Effectiveness of prehospital synchronous direct-current cardioversion for supraventricular tachyarrhythmias causing unstable hemodynamic states. Am J Cardiol. 2003;91:489-91.51. Neuss H, Schlepper M. Long-term efficacy and safety of flecainide for supraventricular tachycardia. Am J Cardiol. 1988;62:56D-61D.52. Cockrell JL, Scheinman MM, Titus C, et al. Safety and efficacy of oral flecainide therapy in patients with atrioventricular re-entrant tachycardia. Ann Intern Med. 1991;114:189-94.53. Jackman WM, Beckman KJ, McClelland JH, et al. Treatment of supraventricular tachycardia due to atrioventricular nodal reentry, by radiofrequency catheter ablation of slow-pathway conduction. N Engl J Med. 1992;327:313-8.54. Gambhir DS, Bhargava M, Nair M, et al. Comparison of electrophysiologic effects and efficacy of single-dose intravenous and long-term oral amiodarone therapy in patients with AV nodal reentrant tachycardia. Indian Heart J. 1996;48:133-7.55. Spector P, Reynolds MR, Calkins H, et al. Meta-analysis of ablation of atrial flutter and supraventricular tachycardia. Am J Cardiol. 2009;104:671-7.56. Bohnen M, Stevenson WG, Tedrow UB, et al. Incidence and predictors of major complications from contemporary catheter ablation to treat cardiac arrhythmias. Heart Rhythm. 2011;8:1661-6.57. Hindricks G. The Multicentre European Radiofrequency Survey (MERFS): complications of radiofrequency catheter ablation of arrhythmias. The Multicentre European Radiofrequency Survey (MERFS) investigators of the Working Group on Arrhythmias of the European Society of Cardiology. Eur Heart J. 1993;14:1644-53.58. Hindricks G. Incidence of complete atrioventricular block following attempted radiofrequency catheter modification of the atrioventricular node in 880 patients. Results of the Multicenter European Radiofrequency Survey (MERFS) The Working Group on Arrhythmias of the European Society of Cardiology. Eur Heart J. 1996;17:82-8.59. Calkins H, Yong P, Miller JM, et al. Catheter ablation of accessory pathways, atrioventricular nodal reentrant tachycardia, and the atrioventricular junction: final results of a prospective, multicenter clinical trial. The Atakr Multicenter Investigators Group. Circulation. 1999;99:262-70.60. Cheng CH, Sanders GD, Hlatky MA, et al. Cost-effectiveness of radiofrequency ablation for supraventricular tachycardia. Ann Intern Med. 2000;133:864-76.61. Scheinman MM, Huang S. The 1998 NASPE prospective catheter ablation registry. Pacing Clin Electrophysiol. 2000;23:1020-8.62. Fox K, Ford I, Steg PG, et al. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372:807-16.63. Swedberg K, Komajda M, Bohm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 2010;376:875-85.64. Cappato R, Castelvecchio S, Ricci C, et al. Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation. J Am Coll Cardiol. 2012;60:1323-9.65. Lee RJ, Kalman JM, Fitzpatrick AP, et al. Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia. Circulation. 1995;92:2919-28.66. Rakovec P. Treatment of inappropriate sinus tachycardia with ivabradine. Wien Klin Wochenschr. 2009;121:715-8.67. Calo L, Rebecchi M, Sette A, et al. Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia. Heart Rhythm. 2010;7:1318-23.68. Kaplinsky E, Comes FP, Urondo LS, et al. Efficacy of ivabradine in four patients with inappropriate sinus tachycardia: a three month-long experience based on electrocardiographic, Holter monitoring, exercise tolerance and quality of life assessments. Cardiol J. 2010;17:166-71.69. Zellerhoff S, Hinterseer M, Felix KB, et al. Ivabradine in patients with inappropriate sinus tachycardia. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:483-6.70. Benezet-Mazuecos J, Rubio JM, Farre J, et al. Long-term outcomes of ivabradine in inappropriate sinus tachycardia patients: appropriate efficacy or inappropriate patients. Pacing Clin Electrophysiol. 2013;36:830-6.71. Ptaszynski P, Kaczmarek K, Ruta J, et al. Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy. Europace. 2013;15:116-21.72. Ptaszynski P, Kaczmarek K, Ruta J, et al. Ivabradine in the treatment of inappropriate sinus tachycardia in patients after successful radiofrequency catheter ablation of atrioventricular node slow pathway. Pacing Clin Electrophysiol. 2013;36:42-9.73. Ptaszynski P, Kaczmarek K, Ruta J, et al. Ivabradine in combination with metoprolol succinate in the treatment of inappropriate sinus tachycardia. J Cardiovasc Pharmacol Ther. 2013;18:338-44.74. Kang KT, Etheridge SP, Kantoch MJ, et al. Current management of focal atrial tachycardia in children: a multicenter experience. Circ Arrhythm Electrophysiol. 2014;7:664-70.75. Callans DJ, Ren JF, Schwartzman D, et al. Narrowing of the superior vena cava-right atrium junction during radiofrequency catheter ablation for inappropriate sinus tachycardia: analysis with intracardiac echocardiography. J Am Coll Cardiol. 1999;33:1667-70.76. Man KC, Knight B, Tse HF, et al. Radiofrequency catheter ablation of inappropriate sinus tachycardia guided by activation mapping. J Am Coll Cardiol. 2000;35:451-7.77. Marrouche NF, Beheiry S, Tomassoni G, et al. Three-dimensional nonfluoroscopic mapping and ablation of inappropriate sinus tachycardia. Procedural strategies and long-term outcome. J Am Coll Cardiol. 2002;39:1046-54.78. Lin D, Garcia F, Jacobson J, et al. Use of noncontact mapping and saline-cooled ablation catheter for sinus node modification in medically refractory inappropriate sinus tachycardia. Pacing Clin Electrophysiol. 2007;30:236-42.79. Frankel DS, Lin D, Anastasio N, et al. Frequent additional tachyarrhythmias in patients with inappropriate sinus tachycardia undergoing sinus node modification: an important cause of symptom recurrence. J Cardiovasc Electrophysiol. 2012;23:835-9.80. Takemoto M, Mukai Y, Inoue S, et al. Usefulness of non-contact mapping for radiofrequency catheter ablation of inappropriate sinus tachycardia: new procedural strategy and long-term clinical outcome. Intern Med. 2012;51:357-62.81. Huang HD, Tamarisa R, Mathur N, et al. Stellate ganglion block: a therapeutic alternative for patients with medically refractory inappropriate sinus tachycardia? J Electrocardiol. 2013;46:693-6.82. Gillette PC, Garson A, Jr. Electrophysiologic and pharmacologic characteristics of automatic ectopic atrial tachycardia. Circulation. 1977;56:571-5.83. Creamer JE, Nathan AW, Camm AJ. Successful treatment of atrial tachycardias with flecainide acetate. Br Heart J. 1985;53:164-6.84. Kunze KP, Kuck KH, Schluter M, et al. Effect of encainide and flecainide on chronic ectopic atrial tachycardia. J Am Coll Cardiol. 1986;7:1121-6.85. Lucet V, Do ND, Fidelle J, et al. [Anti-arrhythmia efficacy of propafenone in children. Apropos of 30 cases]. Arch Mal Coeur Vaiss. 1987;80:1385-93.86. Mehta AV, Sanchez GR, Sacks EJ, et al. Ectopic automatic atrial tachycardia in children: clinical characteristics, management and follow-up. J Am Coll Cardiol. 1988;11:379-85.87. Colloridi V, Perri C, Ventriglia F, et al. Oral sotalol in pediatric atrial ectopic tachycardia. Am Heart J. 1992;123:254-6.88. von Bernuth G, Engelhardt W, Kramer HH, et al. Atrial automatic tachycardia in infancy and childhood. Eur Heart J. 1992;13:1410-5.89. Chen SA, Chiang CE, Yang CJ, et al. Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation. Circulation. 1994;90:1262-78.90. Engelstein ED, Lippman N, Stein KM, et al. Mechanism-specific effects of adenosine on atrial tachycardia. Circulation. 1994;89:2645-54.91. Heusch A, Kramer HH, Krogmann ON, et al. Clinical experience with propafenone for cardiac arrhythmias in the young. Eur Heart J. 1994;15:1050-6.92. Janousek J, Paul T. Safety of oral propafenone in the treatment of arrhythmias in infants and children (European retrospective multicenter study). Working Group on Pediatric Arrhythmias and Electrophysiology of the Association of European Pediatric Cardiologists. Am J Cardiol. 1998;81:1121-4.93. Kalman JM, Olgin JE, Karch MR, et al. "Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography. J Am Coll Cardiol. 1998;31:451-9.94. Markowitz SM, Stein KM, Mittal S, et al. Differential effects of adenosine on focal and macroreentrant atrial tachycardia. J Cardiovasc Electrophysiol. 1999;10:489-502.95. Morton JB, Sanders P, Das A, et al. Focal atrial tachycardia arising from the tricuspid annulus: electrophysiologic and electrocardiographic characteristics. J Cardiovasc Electrophysiol. 2001;12:653-9.96. Kistler PM, Sanders P, Hussin A, et al. Focal atrial tachycardia arising from the mitral annulus: electrocardiographic and electrophysiologic characterization. J Am Coll Cardiol. 2003;41:2212-9.97. Kistler PM, Sanders P, Fynn SP, et al. Electrophysiological and electrocardiographic characteristics of focal atrial tachycardia originating from the pulmonary veins: acute and long-term outcomes of radiofrequency ablation. Circulation. 2003;108:1968-75.98. Gonzalez MD, Contreras LJ, Jongbloed MR, et al. Left atrial tachycardia originating from the mitral annulus-aorta junction. Circulation. 2004;110:3187-92.99. Kistler PM, Fynn SP, Haqqani H, et al. Focal atrial tachycardia from the ostium of the coronary sinus: electrocardiographic and electrophysiological characterization and radiofrequency ablation. J Am Coll Cardiol. 2005;45:1488-93.100. Eidher U, Freihoff F, Kaltenbrunner W, et al. Efficacy and safety of ibutilide for the conversion of monomorphic atrial tachycardia. Pacing Clin Electrophysiol. 2006;29:358-62.101. Ouyang F, Ma J, Ho SY, et al. Focal atrial tachycardia originating from the non-coronary aortic sinus: electrophysiological characteristics and catheter ablation. J Am Coll Cardiol. 2006;48:122-31.102. Roberts-Thomson KC, Kistler PM, Haqqani HM, et al. Focal atrial tachycardias arising from the right atrial appendage: electrocardiographic and electrophysiologic characteristics and radiofrequency ablation. J Cardiovasc Electrophysiol. 2007;18:367-72.103. Medi C, Kalman JM, Haqqani H, et al. Tachycardia-mediated cardiomyopathy secondary to focal atrial tachycardia: long-term outcome after catheter ablation. J Am Coll Cardiol. 2009;53:1791-7.104. Liu X, Dong J, Ho SY, et al. Atrial tachycardia arising adjacent to noncoronary aortic sinus: distinctive atrial activation patterns and anatomic insights. J Am Coll Cardiol. 2010;56:796-804.105. Biviano AB, Bain W, Whang W, et al. Focal left atrial tachycardias not associated with prior catheter ablation for atrial fibrillation: clinical and electrophysiological characteristics. Pacing Clin Electrophysiol. 2012;35:17-27.106. de Loma-Osorio F, Diaz-Infante E, ., et al. Spanish Catheter Ablation Registry. 12th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2012). Rev Esp Cardiol (Engl Ed). 2013;66:983-92.107. Mano H, Okumura Y, Watanabe I, et al. Potential anatomic substrate of peri-atrioventricular nodal atrial tachycardia ablated from the noncoronary sinus of Valsalva. J Interv Card Electrophysiol. 2013;38:27-34.108. Arsura E, Lefkin AS, Scher DL, et al. A randomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of multifocal atrial tachycardia. Am J Med. 1988;85:519-24.109. McCord JK, Borzak S, Davis T, et al. Usefulness of intravenous magnesium for multifocal atrial tachycardia in patients with chronic obstructive pulmonary disease. Am J Cardiol. 1998;81:91-3.110. Iseri LT, Fairshter RD, Hardemann JL, et al. Magnesium and potassium therapy in multifocal atrial tachycardia. Am Heart J. 1985;110:789-94.111. Hazard PB, Burnett CR. Treatment of multifocal atrial tachycardia with metoprolol. Crit Care Med. 1987;15:20-5.112. Waxman HL, Myerburg RJ, Appel R, et al. Verapamil for control of ventricular rate in paroxysmal supraventricular tachycardia and atrial fibrillation or flutter: a double-blind randomized cross-over study. Ann Intern Med. 1981;94:1-6.113. Yeh SJ, Lin FC, Chou YY, et al. Termination of paroxysmal supraventricular tachycardia with a single oral dose of diltiazem and propranolol. Circulation. 1985;71:104-9.114. DiMarco JP, Miles W, Akhtar M, et al. Adenosine for paroxysmal supraventricular tachycardia: dose ranging and comparison with verapamil. Assessment in placebo-controlled, multicenter trials. The Adenosine for PSVT Study Group. Ann Intern Med. 1990;113:104-10.115. Dougherty AH, Jackman WM, Naccarelli GV, et al. Acute conversion of paroxysmal supraventricular tachycardia with intravenous diltiazem. IV Diltiazem Study Group. Am J Cardiol. 1992;70:587-92.116. Langberg JJ, Leon A, Borganelli M, et al. A randomized, prospective comparison of anterior and posterior approaches to radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia. Circulation. 1993;87:1551-6.117. Kalbfleisch SJ, Strickberger SA, Williamson B, et al. Randomized comparison of anatomic and electrogram mapping approaches to ablation of the slow pathway of atrioventricular node reentrant tachycardia. J Am Coll Cardiol. 1994;23:716-23.118. Kopelman HA, Prater SP, Tondato F, et al. Slow pathway catheter ablation of atrioventricular nodal re-entrant tachycardia guided by electroanatomical mapping: a randomized comparison to the conventional approach. Europace. 2003;5:171-4.119. Kimman GP, Theuns DA, Szili-Torok T, et al. CRAVT: a prospective, randomized study comparing transvenous cryothermal and radiofrequency ablation in atrioventricular nodal re-entrant tachycardia. Eur Heart J. 2004;25:2232-7.120. Zrenner B, Dong J, Schreieck J, et al. Transvenous cryoablation versus radiofrequency ablation of the slow pathway for the treatment of atrioventricular nodal re-entrant tachycardia: a prospective randomized pilot study. Eur Heart J. 2004;25:2226-31.121. Kardos A, Paprika D, Shalganov T, et al. Ice mapping during tachycardia in close proximity to the AV node is safe and offers advantages for transcatheter ablation procedures. Acta Cardiol. 2007;62:587-91.122. Deisenhofer I, Zrenner B, Yin YH, et al. Cryoablation versus radiofrequency energy for the ablation of atrioventricular nodal reentrant tachycardia (the CYRANO Study): results from a large multicenter prospective randomized trial. Circulation. 2010;122:2239-45.123. Rodriguez-Entem FJ, Exposito V, Gonzalez-Enriquez S, et al. Cryoablation versus radiofrequency ablation for the treatment of atrioventricular nodal reentrant tachycardia: results of a prospective randomized study. J Interv Card Electrophysiol. 2013;36:41-5.124. Rinkenberger RL, Prystowsky EN, Heger JJ, et al. Effects of intravenous and chronic oral verapamil administration in patients with supraventricular tachyarrhythmias. Circulation. 1980;62:996-1010.125. Das G, Tschida V, Gray R, et al. Efficacy of esmolol in the treatment and transfer of patients with supraventricular tachyarrhythmias to alternate oral antiarrhythmic agents. J Clin Pharmacol. 1988;28:746-50.126. Amsterdam EA, Kulcyski J, Ridgeway MG. Efficacy of cardioselective beta-adrenergic blockade with intravenously administered metoprolol in the treatment of supraventricular tachyarrhythmias. J Clin Pharmacol. 1991;31:714-8.127. Musto B, Cavallaro C, Musto A, et al. Flecainide single oral dose for management of paroxysmal supraventricular tachycardia in children and young adults. Am Heart J. 1992;124:110-5.128. Gambhir DS, Bhargava M, Arora R, et al. Electrophysiologic effects and therapeutic efficacy of intravenous flecainide for termination of paroxysmal supraventricular tachycardia. Indian Heart J. 1995;47:237-43.129. Glatter KA, Cheng J, Dorostkar P, et al. Electrophysiologic effects of adenosine in patients with supraventricular tachycardia. Circulation. 1999;99:1034-40.130. Kay GN, Epstein AE, Dailey SM, et al. Selective radiofrequency ablation of the slow pathway for the treatment of atrioventricular nodal reentrant tachycardia. Evidence for involvement of perinodal myocardium within the reentrant circuit. Circulation. 1992;85:1675-88.131. Bogun F, Knight B, Weiss R, et al. Slow pathway ablation in patients with documented but noninducible paroxysmal supraventricular tachycardia. J Am Coll Cardiol. 1996;28:1000-4.132. D'Este D, Zoppo F, Bertaglia E, et al. Long-term outcome of patients with atrioventricular node reentrant tachycardia. Int J Cardiol. 2007;115:350-3.133. Friedman PL, Dubuc M, Green MS, et al. Catheter cryoablation of supraventricular tachycardia: results of the multicenter prospective "frosty" trial. Heart Rhythm. 2004;1:129-38.134. de Sisti A, Tonet J. Cryoablation of atrioventricular nodal reentrant tachycardia: a clinical review. Pacing Clin Electrophysiol. 2012;35:233-40.135. Hanninen M, Yeung-Lai-Wah N, Massel D, et al. Cryoablation versus RF ablation for AVNRT: A meta-analysis and systematic review. J Cardiovasc Electrophysiol. 2013;24:1354-60.136. Santangeli P, Proietti R, Di BL, et al. Cryoablation versus radiofrequency ablation of atrioventricular nodal reentrant tachycardia. J Interv Card Electrophysiol. 2014;39:111-9.137. Klein GJ, Bashore TM, Sellers TD, et al. Ventricular fibrillation in the Wolff-Parkinson-White syndrome. N Engl J Med. 1979;301:1080-5.138. Rinne C, Klein GJ, Sharma AD, et al. Relation between clinical presentation and induced arrhythmias in the Wolff-Parkinson-White syndrome. Am J Cardiol. 1987;60:576-9.139. Sharma AD, Yee R, Guiraudon G, et al. Sensitivity and specificity of invasive and noninvasive testing for risk of sudden death in Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 1987;10:373-81.140. Gaita F, Giustetto C, Riccardi R, et al. Stress and pharmacologic tests as methods to identify patients with Wolff-Parkinson-White syndrome at risk of sudden death. Am J Cardiol. 1989;64:487-90.141. Beckman KJ, Gallastegui JL, Bauman JL, et al. The predictive value of electrophysiologic studies in untreated patients with Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 1990;15:640-7.142. Pappone C, Vicedomini G, Manguso F, et al. Risk of malignant arrhythmias in initially symptomatic patients with Wolff-Parkinson-White syndrome: results of a prospective long-term electrophysiological follow-up study. Circulation. 2012;125:661-8.143. Spar DS, Silver ES, Hordof AJ, et al. Relation of the utility of exercise testing for risk assessment in pediatric patients with ventricular preexcitation to pathway location. Am J Cardiol. 2012;109:1011-4.144. Wackel P, Irving C, Webber S, et al. Risk stratification in Wolff-Parkinson-White syndrome: the correlation between noninvasive and invasive testing in pediatric patients. Pacing Clin Electrophysiol. 2012;35:1451-7.145. Pappone C, Vicedomini G, Manguso F, et al. Wolff-Parkinson-white syndrome in the era of catheter ablation: insights from a registry study of 2169 patients. Circulation. 2014;130:811-9.146. Sellers TD, Jr., Bashore TM, Gallagher JJ. Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation. Circulation. 1977;56:260-7.147. Sellers TD, Jr., Campbell RW, Bashore TM, et al. Effects of procainamide and quinidine sulfate in the Wolff-Parkinson-White syndrome. Circulation. 1977;55:15-22.148. Hamer A, Peter T, Platt M, et al. Effects of verapamil on supraventricular tachycardia in patients with overt and concealed Wolff-Parkinson-White syndrome. Am Heart J. 1981;101:600-12.149. Hombach V, Braun V, Hopp HW, et al. Antiarrhythmic effects of acute betablockade with atenolol on supraventricular tachycardias at rest and during exercise. Klin Wochenschr. 1981;59:123-33.150. Sheinman BD, Evans T. Acceleration of ventricular rate by fibrillation associated with the Wolff-Parkinson-White syndrome. Br Med J (Clin Res Ed). 1982;285:999-1000.151. Morady F, DiCarlo LA, Jr., Baerman JM, et al. Effect of propranolol on ventricular rate during atrial fibrillation in the Wolff-Parkinson-White syndrome. Pacing Clin Electrophysiol. 1987;10:492-6.152. Schutzenberger W, Leisch F, Gmeiner R. Enhanced accessory pathway conduction following intravenous amiodarone in atrial fibrillation. A case report. Int J Cardiol. 1987;16:93-5.153. Huycke EC, Sung RJ, Dias VC, et al. Intravenous diltiazem for termination of reentrant supraventricular tachycardia: a placebo-controlled, randomized, double-blind, multicenter study. J Am Coll Cardiol. 1989;13:538-44.154. Furlong R, Gerhardt RT, Farber P, et al. Intravenous adenosine as first-line prehospital management of narrow-complex tachycardias by EMS personnel without direct physician control. Am J Emerg Med. 1995;13:383-8.155. Boriani G, Biffi M, Frabetti L, et al. Ventricular fibrillation after intravenous amiodarone in Wolff-Parkinson-White syndrome with atrial fibrillation. Am Heart J. 1996;131:1214-6.156. Glatter KA, Dorostkar PC, Yang Y, et al. Electrophysiological effects of ibutilide in patients with accessory pathways. Circulation. 2001;104:1933-9.157. Shiraishi H, Ishibashi K, Urao N, et al. Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia. Intern Med. 2002;41:445-8.158. Neumar RW, Otto CW, Link MS, et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010;122:S729-S767.159. Delaney B, Loy J, Kelly AM. The relative efficacy of adenosine versus verapamil for the treatment of stable paroxysmal supraventricular tachycardia in adults: a meta-analysis. Eur J Emerg Med. 2011;18:148-52.160. Bauernfeind RA, Wyndham CR, Dhingra RC, et al. Serial electrophysiologic testing of multiple drugs in patients with atrioventricular nodal reentrant paroxysmal tachycardia. Circulation. 1980;62:1341-9.161. Sakurai M, Yasuda H, Kato N, et al. Acute and chronic effects of verapamil in patients with paroxysmal supraventricular tachycardia. Am Heart J. 1983;105:619-28.162. Feld GK, Nademanee K, Weiss J, et al. Electrophysiologic basis for the suppression by amiodarone of orthodromic supraventricular tachycardias complicating pre-excitation syndromes. J Am Coll Cardiol. 1984;3:1298-307.163. Feld GK, Nademanee K, Stevenson W, et al. Clinical and electrophysiologic effects of amiodarone in patients with atrial fibrillation complicating the Wolff-Parkinson-White syndrome. Am Heart J. 1988;115:102-7.164. Hopson JR, Buxton AE, Rinkenberger RL, et al. Safety and utility of flecainide acetate in the routine care of patients with supraventricular tachyarrhythmias: results of a multicenter trial. The Flecainide Supraventricular Tachycardia Study Group. Am J Cardiol. 1996;77:72A-82A.165. Jackman WM, Wang XZ, Friday KJ, et al. Catheter ablation of accessory atrioventricular pathways (Wolff-Parkinson-White syndrome) by radiofrequency current. N Engl J Med. 1991;324:1605-11.166. Calkins H, Langberg J, Sousa J, et al. Radiofrequency catheter ablation of accessory atrioventricular connections in 250 patients. Abbreviated therapeutic approach to Wolff-Parkinson-White syndrome. Circulation. 1992;85:1337-46.167. Kugler JD, Danford DA, Deal BJ, et al. Radiofrequency catheter ablation for tachyarrhythmias in children and adolescents. The Pediatric Electrophysiology Society. N Engl J Med. 1994;330:1481-7.168. Dagres N, Clague JR, Kottkamp H, et al. Radiofrequency catheter ablation of accessory pathways. Outcome and use of antiarrhythmic drugs during follow-up. Eur Heart J. 1999;20:1826-32.169. Schlapfer J, Fromer M. Late clinical outcome after successful radiofrequency catheter ablation of accessory pathways. Eur Heart J. 2001;22:605-9.170. Belhassen B, Rogowski O, Glick A, et al. Radiofrequency ablation of accessory pathways: a 14 year experience at the Tel Aviv Medical Center in 508 patients. Isr Med Assoc J. 2007;9:265-70.171. Milstein S, Sharma AD, Klein GJ. Electrophysiologic profile of asymptomatic Wolff-Parkinson-White pattern. Am J Cardiol. 1986;57:1097-100.172. Satoh M, Aizawa Y, Funazaki T, et al. Electrophysiologic evaluation of asymptomatic patients with the Wolff-Parkinson-White pattern. Pacing Clin Electrophysiol. 1989;12:413-20.173. Klein GJ, Yee R, Sharma AD. Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff-Parkinson-White electrocardiographic pattern. N Engl J Med. 1989;320:1229-33.174. Leitch JW, Klein GJ, Yee R, et al. Prognostic value of electrophysiology testing in asymptomatic patients with Wolff-Parkinson-White pattern. Circulation. 1990;82:1718-23.175. Brembilla-Perrot B, Holban I, Houriez P, et al. Influence of age on the potential risk of sudden death in asymptomatic Wolff-Parkinson-White syndrome. Pacing Clin Electrophysiol. 2001;24:1514-8.176. Pappone C, Santinelli V, Rosanio S, et al. Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study. J Am Coll Cardiol. 2003;41:239-44.177. Pappone C, Santinelli V, Manguso F, et al. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome. N Engl J Med. 2003;349:1803-11.178. Santinelli V, Radinovic A, Manguso F, et al. Asymptomatic ventricular preexcitation: a long-term prospective follow-up study of 293 adult patients. Circ Arrhythm Electrophysiol. 2009;2:102-7.179. Platia EV, Michelson EL, Porterfield JK, et al. Esmolol versus verapamil in the acute treatment of atrial fibrillation or atrial flutter. Am J Cardiol. 1989;63:925-9.180. Salerno DM, Dias VC, Kleiger RE, et al. Efficacy and safety of intravenous diltiazem for treatment of atrial fibrillation and atrial flutter. The Diltiazem-Atrial Fibrillation/Flutter Study Group. Am J Cardiol. 1989;63:1046-51.181. Van Gelder IC, Crijns HJ, Van Gilst WH, et al. Efficacy and safety of flecainide acetate in the maintenance of sinus rhythm after electrical cardioversion of chronic atrial fibrillation or atrial flutter. Am J Cardiol. 1989;64:1317-21.182. Suttorp MJ, Kingma JH, Jessurun ER, et al. The value of class IC antiarrhythmic drugs for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. J Am Coll Cardiol. 1990;16:1722-7.183. Ellenbogen KA, Dias VC, Plumb VJ, et al. A placebo-controlled trial of continuous intravenous diltiazem infusion for 24-hour heart rate control during atrial fibrillation and atrial flutter: a multicenter study. J Am Coll Cardiol. 1991;18:891-7.184. Van Gelder IC, Crijns HJ, Van Gilst WH, et al. Prediction of uneventful cardioversion and maintenance of sinus rhythm from direct-current electrical cardioversion of chronic atrial fibrillation and flutter. Am J Cardiol. 1991;68:41-6.185. Kingma JH, Suttorp MJ. Acute pharmacologic conversion of atrial fibrillation and flutter: the role of flecainide, propafenone, and verapamil. Am J Cardiol. 1992;70:56A-60A.186. Roberts SA, Diaz C, Nolan PE, et al. Effectiveness and costs of digoxin treatment for atrial fibrillation and flutter. Am J Cardiol. 1993;72:567-73.187. Tucker KJ, Wilson C. A comparison of transoesophageal atrial pacing and direct current cardioversion for the termination of atrial flutter: a prospective, randomised clinical trial. Br Heart J. 1993;69:530-5.188. Ellenbogen KA, Dias VC, Cardello FP, et al. Safety and efficacy of intravenous diltiazem in atrial fibrillation or atrial flutter. Am J Cardiol. 1995;75:45-9.189. Hou ZY, Chang MS, Chen CY, et al. Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. A randomized, digoxin-controlled study. Eur Heart J. 1995;16:521-8.190. Sung RJ, Tan HL, Karagounis L, et al. Intravenous sotalol for the termination of supraventricular tachycardia and atrial fibrillation and flutter: a multicenter, randomized, double-blind, placebo-controlled study. Sotalol Multicenter Study Group. Am Heart J. 1995;129:739-48.191. Doni F, Staffiere E, Manfredi M, et al. Type II atrial flutter interruption with transesophageal pacing: use of propafenone and possible change of the substrate. Pacing Clin Electrophysiol. 1996;19:1958-61.192. Ellenbogen KA, Stambler BS, Wood MA, et al. Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study. J Am Coll Cardiol. 1996;28:130-6.193. Stambler BS, Wood MA, Ellenbogen KA, et al. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Ibutilide Repeat Dose Study Investigators. Circulation. 1996;94:1613-21.194. Volgman AS, Carberry PA, Stambler B, et al. Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation. J Am Coll Cardiol. 1998;31:1414-9.195. Vos MA, Golitsyn SR, Stangl K, et al. Superiority of ibutilide (a new class III agent) over DL-sotalol in converting atrial flutter and atrial fibrillation. The Ibutilide/Sotalol Comparator Study Group. Heart. 1998;79:568-75.196. Benditt DG, Williams JH, Jin J, et al. Maintenance of sinus rhythm with oral d,l-sotalol therapy in patients with symptomatic atrial fibrillation and/or atrial flutter. d,l-Sotalol Atrial Fibrillation/Flutter Study Group. Am J Cardiol. 1999;84:270-7.197. Doni F, Manfredi M, Piemonti C, et al. New onset atrial flutter termination by overdrive transoesophageal pacing: effects of different protocols of stimulation. Europace. 2000;2:292-6.198. Natale A, Newby KH, Pisano E, et al. Prospective randomized comparison of antiarrhythmic therapy versus first-line radiofrequency ablation in patients with atrial flutter. J Am Coll Cardiol. 2000;35:1898-904.199. Delacretaz E, Ganz LI, Soejima K, et al. Multi atrial maco-re-entry circuits in adults with repaired congenital heart disease: entrainment mapping combined with three-dimensional electroanatomic mapping. J Am Coll Cardiol. 2001;37:1665-76.200. Delle Karth G, Geppert A, Neunteufl T, et al. Amiodarone versus diltiazem for rate control in critically ill patients with atrial tachyarrhythmias. Crit Care Med. 2001;29:1149-53.201. Pedersen OD, Bagger H, Keller N, et al. Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function: a Danish investigations of arrhythmia and mortality on dofetilide (diamond) substudy. Circulation. 2001;104:292-6.202. Gallagher MM, Guo XH, Poloniecki JD, et al. Initial energy setting, outcome and efficiency in direct current cardioversion of atrial fibrillation and flutter. J Am Coll Cardiol. 2001;38:1498-504.203. Wazni O, Marrouche NF, Martin DO, et al. Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation versus pulmonary vein-left atrial junction disconnection alone in patients presenting with typical atrial flutter and atrial fibrillation. Circulation. 2003;108:2479-83.204. Da Costa A, Thevenin J, Roche F, et al. Results from the Loire-Ardeche-Drome-Isere-Puy-de-Dome (LADIP) trial on atrial flutter, a multicentric prospective randomized study comparing amiodarone and radiofrequency ablation after the first episode of symptomatic atrial flutter. Circulation. 2006;114:1676-81.205. Kuniss M, Vogtmann T, Ventura R, et al. Prospective randomized comparison of durability of bidirectional conduction block in the cavotricuspid isthmus in patients after ablation of common atrial flutter using cryothermy and radiofrequency energy: the CRYOTIP study. Heart Rhythm. 2009;6:1699-705.206. Steinwender C, Honig S, Kypta A, et al. Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter. Int J Cardiol. 2010;141:260-5.207. Bastani H, Drca N, Insulander P, et al. Cryothermal vs. radiofrequency ablation as atrial flutter therapy: a randomized comparison. Europace. 2013;15:420-8.208. Mohanty S, Mohanty P, Di BL, et al. Results from a single-blind, randomized study comparing the impact of different ablation approaches on long-term procedure outcome in coexistent atrial fibrillation and flutter (APPROVAL). Circulation. 2013;127:1853-60.209. Pietersen AH, Hellemann H. Usefulness of flecainide for prevention of paroxysmal atrial fibrillation and flutter. Danish-Norwegian Flecainide Multicenter Study Group. Am J Cardiol. 1991;67:713-7.210. Aliot E, Denjoy I. Comparison of the safety and efficacy of flecainide versus propafenone in hospital out-patients with symptomatic paroxysmal atrial fibrillation/flutter. The Flecainide AF French Study Group. Am J Cardiol. 1996;77:66A-71A.211. Baker BM, Lindsay BD, Bromberg BI, et al. Catheter ablation of clinical intraatrial reentrant tachycardias resulting from previous atrial surgery: localizing and transecting the critical isthmus. J Am Coll Cardiol. 1996;28:411-7.212. Kalman JM, VanHare GF, Olgin JE, et al. Ablation of 'incisional' reentrant atrial tachycardia complicating surgery for congenital heart disease. Use of entrainment to define a critical isthmus of conduction. Circulation. 1996;93:502-12.213. Triedman JK, Bergau DM, Saul JP, et al. Efficacy of radiofrequency ablation for control of intraatrial reentrant tachycardia in patients with congenital heart disease. J Am Coll Cardiol. 1997;30:1032-8.214. Huang DT, Monahan KM, Zimetbaum P, et al. Hybrid pharmacologic and ablative therapy: a novel and effective approach for the management of atrial fibrillation. J Cardiovasc Electrophysiol. 1998;9:462-9.215. Chan DP, Van Hare GF, Mackall JA, et al. Importance of atrial flutter isthmus in postoperative intra-atrial reentrant tachycardia. Circulation. 2000;102:1283-9.216. Jais P, Shah DC, Haissaguerre M, et al. Mapping and ablation of left atrial flutters. Circulation. 2000;101:2928-34.217. Reithmann C, Hoffmann E, Spitzlberger G, et al. Catheter ablation of atrial flutter due to amiodarone therapy for paroxysmal atrial fibrillation. Eur Heart J. 2000;21:565-72.218. Akar JG, Kok LC, Haines DE, et al. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease. J Am Coll Cardiol. 2001;38:377-84.219. Nakagawa H, Shah N, Matsudaira K, et al. Characterization of reentrant circuit in macroreentrant right atrial tachycardia after surgical repair of congenital heart disease: isolated channels between scars allow "focal" ablation. Circulation. 2001;103:699-709.220. Deal BJ, Mavroudis C, Backer CL, et al. Comparison of anatomic isthmus block with the modified right atrial maze procedure for late atrial tachycardia in Fontan patients. Circulation. 2002;106:575-9.221. Coffey JO, d'Avila A, Dukkipati S, et al. Catheter ablation of scar-related atypical atrial flutter. Europace. 2013;15:414-9.222. Ghali WA, Wasil BI, Brant R, et al. Atrial flutter and the risk of thromboembolism: a systematic review and meta-analysis. Am J Med. 2005;118:101-7.223. Mamchur SE, Kurilin MY. High-amplitude pace mapping increases safety of radiofrequency catheter ablation of parahisian ectopic foci. Pacing Clin Electrophysiol. 2012;35:1458-63.224. Ruder MA, Davis JC, Eldar M, et al. Clinical and electrophysiologic characterization of automatic junctional tachycardia in adults. Circulation. 1986;73:930-7.225. Cook JR, Steinberg JS. An incessant form of junctional ectopic tachycardia in an adult responsive to a class 1C agent. Am Heart J. 1991;122:1487-9.226. Kuck KH, Kunze KP, Schluter M, et al. Encainide versus flecainide for chronic atrial and junctional ectopic tachycardia. Am J Cardiol. 1988;62:37L-44L.227. Villain E, Vetter VL, Garcia JM, et al. Evolving concepts in the management of congenital junctional ectopic tachycardia. A multicenter study. Circulation. 1990;81:1544-9.228. Paul T, Reimer A, Janousek J, et al. Efficacy and safety of propafenone in congenital junctional ectopic tachycardia. J Am Coll Cardiol. 1992;20:911-4.229. Raja P, Hawker RE, Chaikitpinyo A, et al. Amiodarone management of junctional ectopic tachycardia after cardiac surgery in children. Br Heart J. 1994;72:261-5.230. Lee KL, Chun HM, Liem LB, et al. Effect of adenosine and verapamil in catecholamine-induced accelerated atrioventricular junctional rhythm: insights into the underlying mechanism. Pacing Clin Electrophysiol. 1999;22:866-70.231. Sarubbi B, Musto B, Ducceschi V, et al. Congenital junctional ectopic tachycardia in children and adolescents: a 20 year experience based study. Heart. 2002;88:188-90.232. Scheinman MM, Gonzalez RP, Cooper MW, et al. Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia. Am J Cardiol. 1994;74:565-72.233. Hamdan M, Van Hare GF, Fisher W, et al. Selective catheter ablation of the tachycardia focus in patients with nonreentrant junctional tachycardia. Am J Cardiol. 1996;78:1292-7.234. Law IH, Von Bergen NH, Gingerich JC, et al. Transcatheter cryothermal ablation of junctional ectopic tachycardia in the normal heart. Heart Rhythm. 2006;3:903-7.235. Meiltz A, Weber R, Halimi F, et al. Permanent form of junctional reciprocating tachycardia in adults: peculiar features and results of radiofrequency catheter ablation. Europace. 2006;8:21-8.236. Padanilam BJ, Manfredi JA, Steinberg LA, et al. Differentiating junctional tachycardia and atrioventricular node re-entry tachycardia based on response to atrial extrastimulus pacing. J Am Coll Cardiol. 2008;52:1711-7.237. Srivathsan K, Gami AS, Barrett R, et al. Differentiating atrioventricular nodal reentrant tachycardia from junctional tachycardia: novel application of the delta H-A interval. J Cardiovasc Electrophysiol. 2008;19:1-6.238. Fan R, Tardos JG, Almasry I, et al. Novel use of atrial overdrive pacing to rapidly differentiate junctional tachycardia from atrioventricular nodal reentrant tachycardia. Heart Rhythm. 2011;8:840-4.239. Lundberg A. Paroxysmal atrial tachycardia in infancy: long-term follow-up study of 49 subjects. Pediatrics. 1982;70:638-42.240. Deal BJ, Keane JF, Gillette PC, et al. Wolff-Parkinson-White syndrome and supraventricular tachycardia during infancy: management and follow-up. J Am Coll Cardiol. 1985;5:130-5.241. Perry JC, Garson A, Jr. Supraventricular tachycardia due to Wolff-Parkinson-White syndrome in children: early disappearance and late recurrence. J Am Coll Cardiol. 1990;16:1215-20.242. Wu MH, Chang YC, Lin JL, et al. Probability of supraventricular tachycardia recurrence in pediatric patients. Cardiology. 1994;85:284-9.243. Riggs TW, Byrd JA, Weinhouse E. Recurrence risk of supraventricular tachycardia in pediatric patients. Cardiology. 1999;91:25-30.244. Tortoriello TA, Snyder CS, Smith EO, et al. Frequency of recurrence among infants with supraventricular tachycardia and comparison of recurrence rates among those with and without preexcitation and among those with and without response to digoxin and/or propranolol therapy. Am J Cardiol. 2003;92:1045-9.245. Gilljam T, Jaeggi E, Gow RM. Neonatal supraventricular tachycardia: outcomes over a 27-year period at a single institution. Acta Paediatr. 2008;97:1035-9.246. Santinelli V, Radinovic A, Manguso F, et al. The natural history of asymptomatic ventricular pre-excitation a long-term prospective follow-up study of 184 asymptomatic children. J Am Coll Cardiol. 2009;53:275-80.247. Salerno JC, Garrison MM, Larison C, et al. Case fatality in children with supraventricular tachycardia in the United States. Pacing Clin Electrophysiol. 2011;34:832-6.248. Garson A, Jr., Gillette PC. Electrophysiologic studies of supraventricular tachycardia in children. I. Clinical-electrophysiologic correlations. Am Heart J. 1981;102:233-50.249. Ko JK, Deal BJ, Strasburger JF, et al. Supraventricular tachycardia mechanisms and their age distribution in pediatric patients. Am J Cardiol. 1992;69:1028-32.250. Weindling SN, Saul JP, Walsh EP. Efficacy and risks of medical therapy for supraventricular tachycardia in neonates and infants. Am Heart J. 1996;131:66-72.251. Gross GJ, Epstein MR, Walsh EP, et al. Characteristics, management, and midterm outcome in infants with atrioventricular nodal reentry tachycardia. Am J Cardiol. 1998;82:956-60.252. Anand RG, Rosenthal GL, Van Hare GF, et al. Is the mechanism of supraventricular tachycardia in pediatrics influenced by age, gender or ethnicity? Congenit Heart Dis. 2009;4:464-8.253. Brembilla-Perrot B, Moulin-Zinsch A, Sellal JM, et al. Impact of transesophageal electrophysiologic study to elucidate the mechanism of arrhythmia on children with supraventricular tachycardia and no preexcitation. Pediatr Cardiol. 2013;34:1695-702.254. Pfammatter JP, Stocker FP. Re-entrant supraventricular tachycardia in infancy: current role of prophylactic digoxin treatment. Eur J Pediatr. 1998;157:101-6.255. Villain E, Bonnet D, Acar P, et al. [Recommendations for the treatment of recurrent supraventricular tachycardia in infants]. Arch Pediatr. 1998;5:133-8.256. Losek JD, Endom E, Dietrich A, et al. Adenosine and pediatric supraventricular tachycardia in the emergency department: multicenter study and review. Ann Emerg Med. 1999;33:185-91.257. Dixon J, Foster K, Wyllie J, et al. Guidelines and adenosine dosing in supraventricular tachycardia. Arch Dis Child. 2005;90:1190-1.258. Chang PM, Silka MJ, Moromisato DY, et al. Amiodarone versus procainamide for the acute treatment of recurrent supraventricular tachycardia in pediatric patients. Circ Arrhythm Electrophysiol. 2010;3:134-40.259. Diaz-Parra S, Sanchez-Yanez P, Zabala-Arguelles I, et al. Use of adenosine in the treatment of supraventricular tachycardia in a pediatric emergency department. Pediatr Emerg Care. 2014;30:388-93.260. Batra AS, Chun DS, Johnson TR, et al. A prospective analysis of the incidence and risk factors associated with junctional ectopic tachycardia following surgery for congenital heart disease. Pediatr Cardiol. 2006;27:51-5.261. Andreasen JB, Johnsen SP, Ravn HB. Junctional ectopic tachycardia after surgery for congenital heart disease in children. Intensive Care Med. 2008;34:895-902.262. Borgman KY, Smith AH, Owen JP, et al. A genetic contribution to risk for postoperative junctional ectopic tachycardia in children undergoing surgery for congenital heart disease. Heart Rhythm. 2011;8:1900-4.263. Makhoul M, Oster M, Fischbach P, et al. Junctional ectopic tachycardia after congenital heart surgery in the current surgical era. Pediatr Cardiol. 2013;34:370-4.264. Pfammatter JP, Paul T, Ziemer G, et al. Successful management of junctional tachycardia by hypothermia after cardiac operations in infants. Ann Thorac Surg. 1995;60:556-60.265. Walsh EP, Saul JP, Sholler GF, et al. Evaluation of a staged treatment protocol for rapid automatic junctional tachycardia after operation for congenital heart disease. J Am Coll Cardiol. 1997;29:1046-53.266. Laird WP, Snyder CS, Kertesz NJ, et al. Use of intravenous amiodarone for postoperative junctional ectopic tachycardia in children. Pediatr Cardiol. 2003;24:133-7.267. Plumpton K, Justo R, Haas N. Amiodarone for post-operative junctional ectopic tachycardia. Cardiol Young. 2005;15:13-8.268. Haas NA, Camphausen CK. Impact of early and standardized treatment with amiodarone on therapeutic success and outcome in pediatric patients with postoperative tachyarrhythmia. J Thorac Cardiovasc Surg. 2008;136:1215-22.269. Collins KK, Van Hare GF, Kertesz NJ, et al. Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies. J Am Coll Cardiol. 2009;53:690-7.270. Kovacikova L, Hakacova N, Dobos D, et al. Amiodarone as a first-line therapy for postoperative junctional ectopic tachycardia. Ann Thorac Surg. 2009;88:616-22.271. Timmermans C, Smeets JL, Rodriguez LM, et al. Aborted sudden death in the Wolff-Parkinson-White syndrome. Am J Cardiol. 1995;76:492-4.272. Ceresnak SR, Tanel RE, Pass RH, et al. Clinical and electrophysiologic characteristics of antidromic tachycardia in children with Wolff-Parkinson-White syndrome. Pacing Clin Electrophysiol. 2012;35:480-8.273. Brembilla-Perrot B, Pauriah M, Sellal JM, et al. Incidence and prognostic significance of spontaneous and inducible antidromic tachycardia. Europace. 2013;15:871-6.274. Kugler JD, Danford DA, Houston K, et al. Radiofrequency catheter ablation for paroxysmal supraventricular tachycardia in children and adolescents without structural heart disease. Pediatric EP Society, Radiofrequency Catheter Ablation Registry. Am J Cardiol. 1997;80:1438-43.275. Schaffer MS, Gow RM, Moak JP, et al. Mortality following radiofrequency catheter ablation (from the Pediatric Radiofrequency Ablation Registry). Participating members of the Pediatric Electrophysiology Society. Am J Cardiol. 2000;86:639-43.276. Blaufox AD, Felix GL, Saul JP. Radiofrequency catheter ablation in infants </=18 months old: when is it done and how do they fare?: short-term data from the pediatric ablation registry. Circulation. 2001;104:2803-8.277. Blaufox AD, Paul T, Saul JP. Radiofrequency catheter ablation in small children: relationship of complications to application dose. Pacing Clin Electrophysiol. 2004;27:224-9.278. Van Hare GF, Javitz H, Carmelli D, et al. Prospective assessment after pediatric cardiac ablation: demographics, medical profiles, and initial outcomes. J Cardiovasc Electrophysiol. 2004;15:759-70.279. Van Hare GF, Javitz H, Carmelli D, et al. Prospective assessment after pediatric cardiac ablation: recurrence at 1 year after initially successful ablation of supraventricular tachycardia. Heart Rhythm. 2004;1:188-96.280. Aiyagari R, Saarel EV, Etheridge SP, et al. Radiofrequency ablation for supraventricular tachycardia in children < or =15 kg is safe and effective. Pediatr Cardiol. 2005;26:622-6.281. Lee PC, Hwang B, Chen SA, et al. The results of radiofrequency catheter ablation of supraventricular tachycardia in children. Pacing Clin Electrophysiol. 2007;30:655-61.282. Buddhe S, Singh H, Du W, et al. Radiofrequency and cryoablation therapies for supraventricular arrhythmias in the young: five-year review of efficacies. Pacing Clin Electrophysiol. 2012;35:711-7.283. Schneider HE, Kriebel T, Gravenhorst VD, et al. Incidence of coronary artery injury immediately after catheter ablation for supraventricular tachycardias in infants and children. Heart Rhythm. 2009;6:461-7.284. Kantoch MJ, Gulamhusein SS, Sanatani S. Short- and long-term outcomes in children undergoing radiofrequency catheter ablation before their second birthday. Can J Cardiol. 2011;27:523-9.285. Garson A, Jr., Kanter RJ. Management of the child with Wolff-Parkinson-White syndrome and supraventricular tachycardia: model for cost effectiveness. J Cardiovasc Electrophysiol. 1997;8:1320-6.286. Pfammatter JP, Pavlovic M, Bauersfeld U. Impact of curative ablation on pharmacologic management in children with reentrant supraventricular tachycardias. Int J Cardiol. 2004;94:279-82.287. Strieper M, Leong T, Bajaj T, et al. Does ablation of supraventricular tachycardia in children with a structurally normal heart improve quality of life? Congenit Heart Dis. 2010;5:587-93.288. Wood KA, Stewart AL, Drew BJ, et al. Patient perception of symptoms and quality of life following ablation in patients with supraventricular tachycardia. Heart Lung. 2010;39:12-20.289. Engelfriet P, Boersma E, Oechslin E, et al. The spectrum of adult congenital heart disease in Europe: morbidity and mortality in a 5 year follow-up period. The Euro Heart Survey on adult congenital heart disease. Eur Heart J. 2005;26:2325-33.290. Verheugt CL, Uiterwaal CS, van der Velde ET, et al. Gender and outcome in adult congenital heart disease. Circulation. 2008;118:26-32.291. Bouchardy J, Therrien J, Pilote L, et al. Atrial arrhythmias in adults with congenital heart disease. Circulation. 2009;120:1679-86.292. Trojnarska O, Grajek S, Kramer L, et al. Risk factors of supraventricular arrhythmia in adults with congenital heart disease. Cardiol J. 2009;16:218-26.293. Bernier M, Marelli AJ, Pilote L, et al. Atrial arrhythmias in adult patients with right- versus left-sided congenital heart disease anomalies. Am J Cardiol. 2010;106:547-51.294. Khairy P, Aboulhosn J, Gurvitz MZ, et al. Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation. 2010;122:868-75.295. Cuypers JA, Opic P, Menting ME, et al. The unnatural history of an atrial septal defect: longitudinal 35 year follow up after surgical closure at young age. Heart. 2013;99:1346-52.296. Valente AM, Gauvreau K, Assenza GE, et al. Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort. Heart. 2014;100:247-53.297. Collins KK, Love BA, Walsh EP, et al. Location of acutely successful radiofrequency catheter ablation of intraatrial reentrant tachycardia in patients with congenital heart disease. Am J Cardiol. 2000;86:969-74.298. de Groot NM, Zeppenfeld K, Wijffels MC, et al. Ablation of focal atrial arrhythmia in patients with congenital heart defects after surgery: role of circumscribed areas with heterogeneous conduction. Heart Rhythm. 2006;3:526-35.299. Mah DY, Alexander ME, Cecchin F, et al. The electroanatomic mechanisms of atrial tachycardia in patients with tetralogy of Fallot and double outlet right ventricle. J Cardiovasc Electrophysiol. 2011;22:1013-7.300. Koyak Z, Kroon B, de Groot JR, et al. Efficacy of antiarrhythmic drugs in adults with congenital heart disease and supraventricular tachycardias. Am J Cardiol. 2013;112:1461-7.301. Wasmer K, Kobe J, Dechering DG, et al. Isthmus-dependent right atrial flutter as the leading cause of atrial tachycardias after surgical atrial septal defect repair. Int J Cardiol. 2013;168:2447-52.302. Fish FA, Gillette PC, Benson DW, Jr. Proarrhythmia, cardiac arrest and death in young patients receiving encainide and flecainide. The Pediatric Electrophysiology Group. J Am Coll Cardiol. 1991;18:356-65.303. Thorne SA, Barnes I, Cullinan P, et al. Amiodarone-associated thyroid dysfunction: risk factors in adults with congenital heart disease. Circulation. 1999;100:149-54.304. Pass RH, Liberman L, Al-Fayaddh M, et al. Continuous intravenous diltiazem infusion for short-term ventricular rate control in children. Am J Cardiol. 2000;86:559-62, A9.305. Hoyer AW, Balaji S. The safety and efficacy of ibutilide in children and in patients with congenital heart disease. Pacing Clin Electrophysiol. 2007;30:1003-8.306. Khairy P, Harris L, Landzberg MJ, et al. Sudden death and defibrillators in transposition of the great arteries with intra-atrial baffles: a multicenter study. Circ Arrhythm Electrophysiol. 2008;1:250-7.307. Miyazaki A, Ohuchi H, Kurosaki K, et al. Efficacy and safety of sotalol for refractory tachyarrhythmias in congenital heart disease. Circ J. 2008;72:1998-2003.308. Rao SO, Boramanand NK, Burton DA, et al. Atrial tachycardias in young adults and adolescents with congenital heart disease: conversion using single dose oral sotalol. Int J Cardiol. 2009;136:253-7.309. Wells R, Khairy P, Harris L, et al. Dofetilide for atrial arrhythmias in congenital heart disease: a multicenter study. Pacing Clin Electrophysiol. 2009;32:1313-8.310. Garnock-Jones KP. Esmolol: a review of its use in the short-term treatment of tachyarrhythmias and the short-term control of tachycardia and hypertension. Drugs. 2012;72:109-32.311. Banchs JE, Baquero GA, Nickolaus MJ, et al. Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease. Congenit Heart Dis. 2014;9:221-7.312. Stan MN, Hess EP, Bahn RS, et al. A risk prediction index for amiodarone-induced thyrotoxicosis in adults with congenital heart disease. J Thyroid Res. 2012;2012:210529.313. Olshansky B, Okumura K, Hess PG, et al. Use of procainamide with rapid atrial pacing for successful conversion of atrial flutter to sinus rhythm. J Am Coll Cardiol. 1988;11:359-64.314. Silka MJ, Manwill JR, Kron J, et al. Bradycardia-mediated tachyarrhythmias in congenital heart disease and responses to chronic pacing at physiologic rates. Am J Cardiol. 1990;65:488-93.315. Ragonese P, Drago F, Guccione P, et al. Permanent overdrive atrial pacing in the chronic management of recurrent postoperative atrial reentrant tachycardia in patients with complex congenital heart disease. Pacing Clin Electrophysiol. 1997;20:2917-23.316. Brockmeier K, Ulmer HE, Hessling G. Termination of atrial reentrant tachycardias by using transesophageal atrial pacing. J Electrocardiol. 2002;35 Suppl:159-63.317. Stephenson EA, Casavant D, Tuzi J, et al. Efficacy of atrial antitachycardia pacing using the Medtronic AT500 pacemaker in patients with congenital heart disease. Am J Cardiol. 2003;92:871-6.318. Ammash NM, Phillips SD, Hodge DO, et al. Outcome of direct current cardioversion for atrial arrhythmias in adults with congenital heart disease. Int J Cardiol. 2012;154:270-4.319. Triedman JK, Saul JP, Weindling SN, et al. Radiofrequency ablation of intra-atrial reentrant tachycardia after surgical palliation of congenital heart disease. Circulation. 1995;91:707-14.320. Tanner H, Lukac P, Schwick N, et al. Irrigated-tip catheter ablation of intraatrial reentrant tachycardia in patients late after surgery of congenital heart disease. Heart Rhythm. 2004;1:268-75.321. Lukac P, Pedersen AK, Mortensen PT, et al. Ablation of atrial tachycardia after surgery for congenital and acquired heart disease using an electroanatomic mapping system: Which circuits to expect in which substrate? Heart Rhythm. 2005;2:64-72.322. de Groot NM, Atary JZ, Blom NA, et al. Long-term outcome after ablative therapy of postoperative atrial tachyarrhythmia in patients with congenital heart disease and characteristics of atrial tachyarrhythmia recurrences. Circ Arrhythm Electrophysiol. 2010;3:148-54.323. Yap SC, Harris L, Silversides CK, et al. Outcome of intra-atrial re-entrant tachycardia catheter ablation in adults with congenital heart disease: negative impact of age and complex atrial surgery. J Am Coll Cardiol. 2010;56:1589-96.324. Ueda A, Suman-Horduna I, Mantziari L, et al. Contemporary outcomes of supraventricular tachycardia ablation in congenital heart disease: a single-center experience in 116 patients. Circ Arrhythm Electrophysiol. 2013;6:606-13.325. Teh AW, Medi C, Lee G, et al. Long-term outcome following ablation of atrial flutter occurring late after atrial septal defect repair. Pacing Clin Electrophysiol. 2011;34:431-5.326. Scaglione M, Caponi D, Ebrille E, et al. Very long-term results of electroanatomic-guided radiofrequency ablation of atrial arrhythmias in patients with surgically corrected atrial septal defect. Europace. 2014.327. Cappato R, Schluter M, Weiss C, et al. Radiofrequency current catheter ablation of accessory atrioventricular pathways in Ebstein's anomaly. Circulation. 1996;94:376-83.328. Reich JD, Auld D, Hulse E, et al. The Pediatric Radiofrequency Ablation Registry's experience with Ebstein's anomaly. Pediatric Electrophysiology Society. J Cardiovasc Electrophysiol. 1998;9:1370-7.329. de Groot NM, Lukac P, Blom NA, et al. Long-term outcome of ablative therapy of postoperative supraventricular tachycardias in patients with univentricular heart: a European multicenter study. Circ Arrhythm Electrophysiol. 2009;2:242-8.330. Yap SC, Harris L, Downar E, et al. Evolving electroanatomic substrate and intra-atrial reentrant tachycardia late after Fontan surgery. J Cardiovasc Electrophysiol. 2012;23:339-45.331. Correa R, Sherwin ED, Kovach J, et al. Mechanism and Ablation of Arrhythmia Following Total Cavopulmonary Connection. Circ Arrhythm Electrophysiol. 2015.332. Jones DG, Jarman JW, Lyne JC, et al. The safety and efficacy of trans-baffle puncture to enable catheter ablation of atrial tachycardias following the Mustard procedure: a single centre experience and literature review. Int J Cardiol. 2013;168:1115-20.333. Wu J, Deisenhofer I, Ammar S, et al. Acute and long-term outcome after catheter ablation of supraventricular tachycardia in patients after the Mustard or Senning operation for D-transposition of the great arteries. Europace. 2013;15:886-91.334. Pressley JC, Wharton JM, Tang AS, et al. Effect of Ebstein's anomaly on short- and long-term outcome of surgically treated patients with Wolff-Parkinson-White syndrome. Circulation. 1992;86:1147-55.335. Misaki T, Watanabe G, Iwa T, et al. Surgical treatment of patients with Wolff-Parkinson-White syndrome and associated Ebstein's anomaly. J Thorac Cardiovasc Surg. 1995;110:1702-7.336. Theodoro DA, Danielson GK, Porter CJ, et al. Right-sided maze procedure for right atrial arrhythmias in congenital heart disease. Ann Thorac Surg. 1998;65:149-53.337. Huang CJ, Chiu IS, Lin FY, et al. Role of electrophysiological studies and arrhythmia intervention in repairing Ebstein's anomaly. Thorac Cardiovasc Surg. 2000;48:347-50.338. Mavroudis C, Backer CL, Deal BJ, et al. Total cavopulmonary conversion and maze procedure for patients with failure of the Fontan operation. J Thorac Cardiovasc Surg. 2001;122:863-71.339. Khositseth A, Danielson GK, Dearani JA, et al. Supraventricular tachyarrhythmias in Ebstein anomaly: management and outcome. J Thorac Cardiovasc Surg. 2004;128:826-33.340. Bockeria L, Golukhova E, Dadasheva M, et al. Advantages and disadvantages of one-stage and two-stage surgery for arrhythmias and Ebstein's anomaly. Eur J Cardiothorac Surg. 2005;28:536-40.341. Giamberti A, Chessa M, Foresti S, et al. Combined atrial septal defect surgical closure and irrigated radiofrequency ablation in adult patients. Ann Thorac Surg. 2006;82:1327-31.342. Karamlou T, Silber I, Lao R, et al. Outcomes after late reoperation in patients with repaired tetralogy of Fallot: the impact of arrhythmia and arrhythmia surgery. Ann Thorac Surg. 2006;81:1786-93.343. Stulak JM, Dearani JA, Puga FJ, et al. Right-sided Maze procedure for atrial tachyarrhythmias in congenital heart disease. Ann Thorac Surg. 2006;81:1780-4.344. Mavroudis C, Deal BJ, Backer CL, et al. J. Maxwell Chamberlain Memorial Paper for congenital heart surgery. 111 Fontan conversions with arrhythmia surgery: surgical lessons and outcomes. Ann Thorac Surg. 2007;84:1457-65.345. Giamberti A, Chessa M, Abella R, et al. Surgical treatment of arrhythmias in adults with congenital heart defects. Int J Cardiol. 2008;129:37-41.346. Mavroudis C, Deal BJ, Backer CL, et al. Arrhythmia surgery in patients with and without congenital heart disease. Ann Thorac Surg. 2008;86:857-68.347. Aboulhosn J, Williams R, Shivkumar K, et al. Arrhythmia recurrence in adult patients with single ventricle physiology following surgical Fontan conversion. Congenit Heart Dis. 2010;5:430-4.348. Gutierrez SD, Earing MG, Singh AK, et al. Atrial tachyarrhythmias and the Cox-maze procedure in congenital heart disease. Congenit Heart Dis. 2013;8:434-9.349. Terada T, Sakurai H, Nonaka T, et al. Surgical outcome of Fontan conversion and arrhythmia surgery: Need a pacemaker? Asian Cardiovasc Thorac Ann. 2013;22:682-6.350. Said SM, Burkhart HM, Schaff HV, et al. Fontan conversion: identifying the high-risk patient. Ann Thorac Surg. 2014;97:2115-21.351. Ghosh N, Luk A, Derzko C, et al. The acute treatment of maternal supraventricular tachycardias during pregnancy: a review of the literature. J Obstet Gynaecol Can. 2011;33:17-23.352. Damilakis J, Theocharopoulos N, Perisinakis K, et al. Conceptus radiation dose and risk from cardiac catheter ablation procedures. Circulation. 2001;104:893-7.353. Berruezo A, Diez GR, Berne P, et al. Low exposure radiation with conventional guided radiofrequency catheter ablation in pregnant women. Pacing Clin Electrophysiol. 2007;30:1299-302.354. Szumowski L, Szufladowicz E, Orczykowski M, et al. Ablation of severe drug-resistant tachyarrhythmia during pregnancy. J Cardiovasc Electrophysiol. 2010;21:877-82.355. Lydakis C, Lip GY, Beevers M, et al. Atenolol and fetal growth in pregnancies complicated by hypertension. Am J Hypertens. 1999;12:541-7.356. von Dadelszen P, Ornstein MP, Bull SB, et al. Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet. 2000;355:87-92.357. Bartalena L, Bogazzi F, Braverman LE, et al. Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment. J Endocrinol Invest. 2001;24:116-30.358. Qasqas SA, McPherson C, Frishman WH, et al. Cardiovascular pharmacotherapeutic considerations during pregnancy and lactation. Cardiol Rev. 2004;12:201-21.359. Jaeggi ET, Carvalho JS, De GE, et al. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation. 2011;124:1747-54.360. Chen SA, Lee SH, Wu TJ, et al. Initial onset of accessory pathway-mediated and atrioventricular node reentrant tachycardia after age 65: clinical features, electrophysiologic characteristics, and possible facilitating factors. J Am Geriatr Soc. 1995;43:1370-7.361. Chen SA, Chiang CE, Tai CT, et al. Complications of diagnostic electrophysiologic studies and radiofrequency catheter ablation in patients with tachyarrhythmias: an eight-year survey of 3,966 consecutive procedures in a tertiary referral center. Am J Cardiol. 1996;77:41-6.362. Boulos M, Hoch D, Schecter S, et al. Age dependence of complete heart block complicating radiofrequency ablation of the atrioventricular nodal slow pathway. Am J Cardiol. 1998;82:390-1.363. Zado ES, Callans DJ, Gottlieb CD, et al. Efficacy and safety of catheter ablation in octogenarians. J Am Coll Cardiol. 2000;35:458-62.364. Li YG, Gronefeld G, Bender B, et al. Risk of development of delayed atrioventricular block after slow pathway modification in patients with atrioventricular nodal reentrant tachycardia and a pre-existing prolonged PR interval. Eur Heart J. 2001;22:89-95.365. Porter MJ, Morton JB, Denman R, et al. Influence of age and gender on the mechanism of supraventricular tachycardia. Heart Rhythm. 2004;1:393-6.366. Rostock T, Risius T, Ventura R, et al. Efficacy and safety of radiofrequency catheter ablation of atrioventricular nodal reentrant tachycardia in the elderly. J Cardiovasc Electrophysiol. 2005;16:608-10.367. Kihel J, Da CA, Kihel A, et al. Long-term efficacy and safety of radiofrequency ablation in elderly patients with atrioventricular nodal re-entrant tachycardia. Europace. 2006;8:416-20.368. Dagres N, Piorkowski C, Kottkamp H, et al. Contemporary catheter ablation of arrhythmias in geriatric patients: patient characteristics, distribution of arrhythmias, and outcome. Europace. 2007;9:477-80.369. Haghjoo M, Arya A, Heidari A, et al. Electrophysiologic characteristics and results of radiofrequency catheter ablation in elderly patients with atrioventricular nodal reentrant tachycardia. J Electrocardiol. 2007;40:208-13.370. Pedrinazzi C, Durin O, Agricola P, et al. Efficacy and safety of radiofrequency catheter ablation in the elderly. J Interv Card Electrophysiol. 2007;19:179-85.371. Yangni NO, Brembilla-Perrot B. Clinical characteristics and management of paroxysmal junctional tachycardia in the elderly. Arch Cardiovasc Dis. 2008;101:143-8.372. Hoffmann BA, Brachmann J, Andresen D, et al. Ablation of atrioventricular nodal reentrant tachycardia in the elderly: results from the German Ablation Registry. Heart Rhythm. 2011;8:981-7.373. Saul JP, Scott WA, Brown S, et al. Intravenous amiodarone for incessant tachyarrhythmias in children: a randomized, double-blind, antiarrhythmic drug trial. Circulation. 2005;112:3470-7.374. Manrique AM, Arroyo M, Lin Y, et al. Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study. J Thorac Cardiovasc Surg. 2010;139:162-9.375. Sanatani S, Potts JE, Reed JH, et al. The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants. Circ Arrhythm Electrophysiol. 2012;5:984-91.376. Lau CP, Tai YT, Lee PW. The effects of radiofrequency ablation versus medical therapy on the quality-of-life and exercise capacity in patients with accessory pathway-mediated supraventricular tachycardia: a treatment comparison study. Pacing Clin Electrophysiol. 1995;18:424-32.377. Bubien RS, Knotts-Dolson SM, Plumb VJ, et al. Effect of radiofrequency catheter ablation on health-related quality of life and activities of daily living in patients with recurrent arrhythmias. Circulation. 1996;94:1585-91.378. Bathina MN, Mickelsen S, Brooks C, et al. Radiofrequency catheter ablation versus medical therapy for initial treatment of supraventricular tachycardia and its impact on quality of life and healthcare costs. Am J Cardiol. 1998;82:589-93.379. Larson MS, McDonald K, Young C, et al. Quality of life before and after radiofrequency catheter ablation in patients with drug refractory atrioventricular nodal reentrant tachycardia. Am J Cardiol. 1999;84:471-3, A9.380. Goldberg AS, Bathina MN, Mickelsen S, et al. Long-term outcomes on quality-of-life and health care costs in patients with supraventricular tachycardia (radiofrequency catheter ablation versus medical therapy). Am J Cardiol. 2002;89:1120-3.381. Meissner A, Stifoudi I, Weismuller P, et al. Sustained high quality of life in a 5-year long term follow-up after successful ablation for supra-ventricular tachycardia. results from a large retrospective patient cohort. Int J Med Sci. 2009;6:28-36.382. Yildirim O, Yontar OC, Semiz M, et al. The effect of radiofrequency ablation treatment on quality of life and anxiety in patients with supraventricular tachycardia. Eur Rev Med Pharmacol Sci. 2012;16:2108-12.383. Farkowski MM, Pytkowski M, Maciag A, et al. Gender-related differences in outcomes and resource utilization in patients undergoing radiofrequency ablation of supraventricular tachycardia: results from Patients' Perspective on Radiofrequency Catheter Ablation of AVRT and AVNRT Study. Europace. 2014.384. de Buitleir M, Bove EL, Schmaltz S, et al. Cost of catheter versus surgical ablation in the Wolff-Parkinson-White syndrome. Am J Cardiol. 1990;66:189-92.385. de Buitleir M, Sousa J, Bolling SF, et al. Reduction in medical care cost associated with radiofrequency catheter ablation of accessory pathways. Am J Cardiol. 1991;68:1656-61.386. Kalbfleisch SJ, Calkins H, Langberg JJ, et al. Comparison of the cost of radiofrequency catheter modification of the atrioventricular node and medical therapy for drug-refractory atrioventricular node reentrant tachycardia. J Am Coll Cardiol. 1992;19:1583-7.387. Hogenhuis W, Stevens SK, Wang P, et al. Cost-effectiveness of radiofrequency ablation compared with other strategies in Wolff-Parkinson-White syndrome. Circulation. 1993;88:II437-II446.388. Kalbfleisch SJ, el-Atassi R, Calkins H, et al. Safety, feasibility and cost of outpatient radiofrequency catheter ablation of accessory atrioventricular connections. J Am Coll Cardiol. 1993;21:567-70.389. Kertes PJ, Kalman JM, Tonkin AM. Cost effectiveness of radiofrequency catheter ablation in the treatment of symptomatic supraventricular tachyarrhythmias. Aust N Z J Med. 1993;23:433-6.390. Ikeda T, Sugi K, Enjoji Y, et al. Cost effectiveness of radiofrequency catheter ablation versus medical treatment for paroxysmal supraventricular tachycardia in Japan. J Cardiol. 1994;24:461-8.391. Dewland TA, Glidden DV, Marcus GM. Healthcare utilization and clinical outcomes after catheter ablation of atrial flutter. PLoS One. 2014;9:e100509.392. Domanovits H, Laske H, Stark G, et al. Adenosine for the management of patients with tachycardias-a new protocol. Eur Heart J. 1994;15:589-93.393. Turakhia MP, Santangeli P, Winkelmayer WC, et al. Increased mortality associated with digoxin in contemporary patients with atrial fibrillation: findings from the TREAT-AF study. J Am Coll Cardiol. 2014;64:660-8.394. Tercius AJ, Kluger J, Coleman CI, et al. Intravenous magnesium sulfate enhances the ability of intravenous ibutilide to successfully convert atrial fibrillation or flutter. Pacing Clin Electrophysiol. 2007;30:1331-5.395. Perez FJ, Schubert CM, Parvez B, et al. Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis. Circ Arrhythm Electrophysiol. 2009;2:393-401.396. Natale A, Breeding L, Tomassoni G, et al. Ablation of right and left ectopic atrial tachycardias using a three-dimensional nonfluoroscopic mapping system. Am J Cardiol. 1998;82:989-92.397. Goldberger J, Kall J, Ehlert F, et al. Effectiveness of radiofrequency catheter ablation for treatment of atrial tachycardia. Am J Cardiol. 1993;72:787-93.398. Stevenson IH, Kistler PM, Spence SJ, et al. Scar-related right atrial macroreentrant tachycardia in patients without prior atrial surgery: electroanatomic characterization and ablation outcome. Heart Rhythm. 2005;2:594-601. ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- american college of education scam
- american college of surgery
- american college of neurology
- american college of neurology guidelines
- american college of epi
- american college of insurance
- american college of financial planning
- american college of education employment
- american college of functional neurology
- american college of surgeons
- fellow american college of surgeons
- american college of surgeons abbreviation