CURRICULUM VITAE



Dr. Mathivanan Jothi, PhD

DOB: November 13, 1979 Office : +91 80 26995124/25

G23 C Block ACAS Crescent Square Apt Mobile : +918220455752

Doddakammanahalli Main Road, Bangalore 560076 Email: mjothi@nimhans.ac.in

Tamilnadu, India mathivanan.jothi@

CURRICULUM VITAE

1. Academic Profile

2007 Doctor of Philosophy (PhD),

Department of Human Genetics,

National Institute of Mental Health and Neurosciences (NIMHANS),

Bangalore, Karnataka, India. Pin 560029.

Thesis Entitled: “Molecular studies on the tumor suppressor gene retinoblastoma (RB1) in human brain tumors”

2002 Master of science in Molecular Biology (MSc),

Dept of Biochemistry and Molecular Biology,

University of madras,

Chennai, Tamilnadu, India. Pin 600025.

2000 Bachelor of Science in Biochemistry (BSc),

Bharathiar University,

Coimbatore, Tamilnadu. Pin 641037.

2. Research/Training experience

Jan 2017 onwards Assistant professor, NIMHANS, Bengaluru, India

Aug 2014 to Jan 2017 UGC-Assistant professor, Bharathiar University, Coimbatore, India

Mar 2013 to July 2014 DTI-IMPORT Fellow, San Raffaele Scientific Institute, Milan, Italy

Dec 2012 to Feb 2013 Post-Doctoral Associate, Roswell Park Cancer Institute,

Buffalo, NY USA

Apr 2008 to Dec 2012 Research Affiliate (Post doc), Roswell Park Cancer Institute,

Buffalo, NY USA

Dec 2007 to Mar 2008 Postdoctoral Fellow, Cleveland Clinic, Cleveland, OH, USA

2005 to 2007 Senior Research Fellow, NIMHANS, Bangalore, India

2003 to 2005 Junior Research Fellow, NIMHANS, Bangalore, India

3. Awards/Honors

1. Senior Research Fellow, University Grants Commission, India (UGC-SRF)

2. Junior Research Fellow and eligible for lectureship, University Grants Commission, India (UGC-JRF/LS)

3. Junior Research Fellow, Indian Council of Medical Research, India (ICMR-JRF)

4. Dulbecco Telethon Institute International Mobility for Postdoctoral Research Training (DTI-IMPORT) fellowship, Dulbecco Telethon Institute, Italy

5. Early Career Research Award, Science and Engineering Research Board (SERB), DST, India

Best poster Award

International

6. Best poster award with travel grant (First price)- Presented at Scientific Retreat, Cell Stress and Biophysical Therapies Program & Cell Stress Biology, May 6-7, 2012 Holiday Inn, Grand Island, NY 14072

7. Best poster award (First Place)- Presented at 2010 Postdoc Research Symposium, June 8th, 2010 Center for Tomorrow, North Campus, University at Buffalo, Buffalo, NY 14201

8. Best poster award - Presented at the 10th Congress of Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), Indian Institute of Science, Bangalore, India. December 7-11, 2003

National

9. Best poster award- Presented at the 74th Society of Biological Chemists conference, Lucknow, India. November 7-10, 2005

10. Best poster award- Presented at the “Genes, evolution and complex diseases, an international symposium on human origins and genetics” February 17-19, 2005, held at the National Center for Biological Sciences, Bangalore 560065, India

Invited speaker

11. Dr. MGR College, Hosur, Tamilnadu, India on October 29, 2007

12. Department of Applied Genetics, Acharya Bangalore B School, Andhrahalli Main Road, Magadi Road, Bangalore 560091 on August 12, 2013

13. Refresher course in Biotechnology, Microbial Biotechnology & Bioinformatics (Interdisciplinary) for the university and college teachers on November 7, 2014 at UGC-Academic Staff College, Bharathiar University

14. Refresher course in Chemistry for the university and college teachers on February 16, 2015 at UGC-Academic Staff College, Bharathidasan University, Tiruchirappalli

15. Symposium on Causatives and Curatives of Infectious Diseases on August 19, 2015 at Dr. NGP Arts and Science College, Coimbatore

16. ‘Genes and Genetic center’ delivered in seminar on The Concept of Genetic Centre - The Supreme Brain on February 26, 2017 at NIMHANS, Bengaluru

17. ‘Induction of cellular differentiation-a safe anticancer strategy’ delivered in Special Lecture series on ‘Recent Advance in Biotechnology’ sponsored by Karnataka Science and Technology Academy October 26-28, 2017 at Gulbarga University, Kalaburagi, Karnataka

18. ‘Target based therapeutic approaches for cancer’ delivered in Special Lecture series on ‘Recent Advance in Biotechnology’ sponsored by Karnataka Science and Technology Academy October 26-28, 2017 at Gulbarga University, Kalaburagi, Karnataka

19. ‘Induction of cellular differentiation – a safe cancer therapeutic strategy’ Refresher course in Biotechnology for the university and college teachers on December 2, 2017 at UGC-Academic Staff College, Bharathiar University

20. ‘Targeting Cancer’s Achilles Heel’ Refresher course in Biotechnology for the university and college teachers on December 2, 2017 at UGC-Academic Staff College, Bharathiar University

21. ‘Healthy teacher is the wealthy treasure of knowledge - a focus on cancer facts’ National seminar on Well-being of the teacher as the decisive factors for an efficient instructional matrix on January 29, 2018 at Hindustan College of Education, Coimbatore, Tamilnadu.

22. ‘Targeting transcription factors in cancer-specific therapeutics’ International Conference on Nutraceuticals-Concepts and Applications of disease (ICNCAD-2018), on 16-17 February, 2018 at University of Madras, Chennai, Tamilnadu.

23. ‘Introduction to Epigenetics, Gene-environmental interactions and Gene Therapy’ Workshop on Primer on Genetics of Mental Health and Neurological healthcare professionals on 5 April 2018 at NIMHANS, Bangalore, Karnataka.

24. ‘Research Integrity and publication ethics’ Short Term course on Research Methodology (Sciences), on 16.09.2019 at UGC-Human Resource Development Center, Bharathiar University, Coimbatore.

25. ‘Genome Editing’ Lecture Workshop on Contemporary in Biological sciences organized by Department of Biochemistry on 22.10.2019 at Bharathiar University, Coimbatore.

26. ‘Genes and meditation - How they meet?’ International SKY Doctors Conference-2019 organized by Temple of Consciousness, Aliyar on 01.11.2019.

27. ‘Induction of cellular differentiation– a novel safe cancer therapeutic strategy’ National seminar series on “Recent trends in Life sciences” organized by Christ University, Bengaluru on 11.02.2020.

28. ‘Host immune response for effective removal of viral infection’ DBT STAR College sponsored Webinar series on “Science and Technology trends” organized by Hindustan College of Arts and Science, Coimbatore, Tamilnadu on 12.05.2020.

29. ‘Redifferentiation- a safe cancer approach’ Alumni (webinar) lecture series, organized by Kongunadu Arts and Science College, Coimbatore, Tamilnadu on 05.06.2020.

30. ‘Redifferentiation - a potential anticancer approach’ International Webinar series on “Recent Trends and Challenges in Biotechnology”, Department of Biotechnology, Bharathiar University, Coimbatore, Tamilnadu on 23.06.2020.

4. Papers Published

1. Saravana Mani K*, Rajamanikandan R, Ilanchelian M*, Muralidharan N, Jothi M*, Rajendran SP. Smart phone assisted Quinoline-hemicyanine based fluorescent probe for the selective detection of glutathione and the application in living cells. Spectrochim Acta A Mol Biomol Spectrosc 2020, 243: 118809 IF: 3.232

2. Tharmalingam B, Mathivanan M, Mani KS, Kaminsky W, Raghunath A, Jothi M, Perumal E, Murugesapandian B. Selective detection of pyrophosphate anion by zinc ensemble of C3-symmetric triaminoguanidine-pyrrole conjugate and its biosensing applications. Analytica Chimica Acta 2020, 1103:192–201. IF: 5.256

3. Wolff DW, Lee MH, Jothi M, Mal M, Li F, Mal AK. Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells. Oncotarget. 2018 May 25;9(40):25796-25807. doi: 10.18632/oncotarget.25376. eCollection 2018 May 25. PubMed PMID: 29899822; PubMed Central PMCID: PMC5995248.

4. Chatterjee B, Wolff DW, Jothi M, Mal M, Mal AK. p38α MAPK disables KMT1A-mediated repression of myogenic differentiation program. Skelet Muscle. 2016 Aug 22;6:28. doi: 10.1186/s13395-016-0100-z. eCollection 2016. PubMed PMID: 27551368; PubMed Central PMCID: PMC4993004.

5. Mitra R, Keshava R, Jothi M, Vikas V, Indira Devi B, and Gope R. Bay 61-3606, CDKi and sodium butyrate treatments modulate p53 protein level and its site-specific phosphorylation in human vestibular schwannomas in vitro. Journal of Cancer Research 2014; 2014: 249354 doi: 10.1155/2014/249354

6. Jothi EA, Sundaram M, Namasivayam J, Jothi M. A rare presentation of retiform hemangioendothelioma in the external auditory canal. Case Rep Otolaryngol. 2014; 2014: 715035. doi: 10.1155/2014/715035. Epub 2014 Jul 13. PubMed PMID: 25184066; PubMed Central PMCID: PMC4122065.

7. Neguembor MV, Jothi M, Gabellini D. Long noncoding RNAs, emerging players in muscle differentiation and disease. Skelet Muscle. 2014 Mar 31;4(1):8. doi: 10.1186/2044-5040-4-8. PubMed PMID: 24685002; PubMed Central PMCID: PMC3973619.

8. Jothi M, Mal M, Keller C, Mal AK. Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma. Mol Cancer Ther. 12: 2663-2674, 2013.

9. Jothi M, Mal AK. Too much AKT turns PAX3-FKHR dead: A prospect of novel therapeutic strategy for alveolar rhabdomyosarcoma. Oncotarget. 3(10):1064-5, 2012.

10. Jothi M, Nishijo K, Keller C and Mal A. AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell. Cell Cycle 11(5): 895-908, 2012

11. Lee MH, Jothi M, Gudkov AV, Mal AK. Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State. Cancer Res 71: 3921-3931, 2011

12. K Rohini, J Mathivanan, Mohan L Gope and R Gope. Functional modulation of the p53 gene and its protein in human brain tumors. Ann of Neurosci 15: 75-86, 2008

13. Mathivanan Jothi, Rohini Keshava, Mohan L. Gope, Rajalakshmi Gope. Possible role of the tumor suppressor gene retinoblastoma (RB1) in human brain tumor development. Ann of Neurosci 14: 72-82, 2007

14. J. Mathivanan, K. Rohini, ML. Gope, B. Anandh and R. Gope. Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors. Mol Cell Biochem 302: 67-77, 2007

15. K. Rohini, J. Mathivanan, PD. Antony Herold Prabhu, DK. Subbakrishna, ML. Gope, BA. Chandramouli, S. Sampath, B. Anandh and R. Gope. Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors. Mol Cell Biochem 300: 101-111, 2007

16. PD. Antony Herold Prabhu, R Thomas, J. Mathivanan, K. Rohini, ML. Gope, R. Gope. The tumor suppressor gene (RB1) in human vestibular schwannomas. Ann of Neurosci 13: 113-124, 2006

17. PD. Antony Herold Prabhu, K. Rohini, J. Mathivanan, ML. Gope, R. Gope. The p53 gene and human vestibular schwannomas. Ann of Neurosci 13: 77-91, 2006

18. PD. Antony Herold Prabhu, J. Mathivanan, K. Rohini, R Thomas, ML. Gope, DK. Subbakrishna, S. Sampath, SS. Praharaj, BA. Chandramouli and R. Gope. Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas. Mol Carcinog 45: 38-46, 2006

19. R. Thomas, PD. Antony Herold Prabhu, J. Mathivanan, Rohini, D. Sivakumar, PN. Jayakumar, B. Indira Devi, S. Satish, KVR. Sastry and R. Gope. Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular schwannomas. Mol Cell Biochem 271: 113-121, 2005

20. R. Thomas, J. Mathivanan, K. Rohini, PD. Antony Herold Prabhu, D. Sivakumar, PN. Jayakumar, B. Indira Devi, S. Satish, KVR. Sastry and R. Gope. Deregulation of the tumor suppressor gene retinoblastoma (RB1) in human vestibular schwannomas. In: Genes, evolution and complex disease: an international symposium on human origins and genetics, pp 76-77, 2005

21. K. Rohini, J. Mathivanan, ML. Gope and R. Gope. The tumor suppressor genes RB1 and p53 in human cancers. Advanced Biotech III: 16-19, 2005

22. J. Mathivanan, K. Rohini, R. Thomas, PD. Antony Herold Prabhu, ML. Gope and R. Gope. Molecular medicine, genetic engineering and human genetic disorders. In: Recent advances in Genetics and Health; P. Usha Rani, A. Jothy and M. Hema Prasad (eds.) Institute of genetics and hospital for genetic diseases, Osmania University, Hyderabad, India. Murthy Graphics, Ameerpet, Hyderabad 500 016, India; pages 223-230, 2004

Papers presented/attended at Conferences/Seminars/Symposia

1. Mathivanan Jothi, Participated in AACR Virtual Annual Meeting II 22-24 June 2020

2. Mathivanan Jothi, Participated in AACR Virtual Annual Meeting I 27-28 Apr 2020

3. Mathivanan Jothi, Participated and presented in ECRA 3rd Group Monitoring Workshop (GMW)-DST/SERB 13-15 Feb 2020, BITs-Pilani, Hyderabad Campus, Hyderabad, Telangana

4. Narenkumar Muralidharan, Abinayaselvi Murugan, Prabhu Raj AR, Mathivanan Jothi. “Pax3 act as a double edged sword during neuroblastoma cell differentiation” Presented at XLII All India Cell biology Conference, Indian Institute of Science and Education Research (IISER), December 19-21, 2019, Mohali, India, Abstract number P068 printed in the proceedings page number 104-105

5. Mathivanan Jothi, Participated and presented in 3rd Group Monitoring Workshop (GMW)-DST/SERB EMEQ grant 17-18 May 2019, KIIT University, Bhubaneswar, Odisha.

6. Participated at 7th International symposium on Current Trends in Drug Discovery Research (CTDDR), February 20-23, 2019 Central Drug Research Institute (CDRI) Lucknow, Uttar Pradesh, India.

7. Participated at “44th Annual Conference of the Indian Society of Human Genetics ISHG-2019: Genomics for Health and Precision Medicine” January 30-February 2, 2019, held at Kalyani University, Kalyani, West Bengal, India

8. Abinayaselvi Murugan, Narenkumar Muralidharan, Mathivanan Jothi. “Akt-mediated MyoD regulation during skeletal muscle differentiation” Presented at 2nd International conference on Trends Cell and molecular Biology & XLII All India Cell biology Conference, December 20-23, 2018 BITS Pilani, K K Birla Goa campus, Zuarinagar, Goa, India, Abstract number PP26 printed in the proceedings page number 71-72

9. Narenkumar Muralidharan, Abinayaselvi Murugan, Ashok Arasu, Prabhu Raj AR, Mathivanan Jothi. “Possible role of Transcription factor Pax3 in neuroblastoma growth” Presented at 7th Asian Chromatin meeting, Jawaharlal Nehru Centre for Advanced Scientific Research, November 17-19, 2018 Bangalore, India, Abstract number PP25 printed in the proceedings page number 79

10. Narenkumar Muralidharan, Abinayaselvi Murugan, Ashok Arasu, Nitufa Mulla, Mathivanan Jothi. “Exploring the role of Transcription factor Pax3 in neuroblastoma growth” Presented at Genome Biology 2018: Mechanisms in Health and Disease, July 13-14, 2018, Indian Institute of Science, Bangalore, India, Abstract number P3 printed in the proceedings page number 46

11. Nitufa Mulla, Abinayaselvi Murugan, Narenkumar Muralidharan, Mathivanan Jothi. “Akt-MyoD interplay during skeletal muscle differentiation” Presented at Genome Biology 2018: Mechanisms in Health and Disease, July 13-14, 2018 Indian Institute of Science, Bangalore, India, Abstract number P4 printed in the proceedings page number 46

12. Abinayaselvi Murugan, Narenkumar Muralidharan, Nitufa Mulla, Mathivanan Jothi. “Vinculin isoform switching during muscle differentiation” Presented at Genome Biology 2018: Mechanisms in Health and Disease, July 13-14, 2018 Indian Institute of Science, Bangalore, India, Abstract number P11 printed in the proceedings page number 51

13. Mathivanan Jothi. “Introduction to Epigenetics, Gene-environmental interactions and Gene Therapy” Presented at Workshop on Primer on Genetics of Mental Health and Neurological healthcare professionals, April 5, 2018, NIMHANS, Bangalore, India.

14. Symposium on “Fragile X and Autism Spectrum Disorders”, Feb 28, 2017. NIMHANS, Bengaluru.

15. EPIGEN-MiChroNetwork Chromatin Seminar: “Epigenetic control of development and cell differentiation”, May 7, 2014 Instituto Nazionale Genetica Moleculare (INGM), Padiglione Invernizzi, Via Francesco Sforza, 35, Milano, Milan, Italy

16. EPIGEN-MiChroNetwork Chromatin Seminar: March 4, 2014 Università degli Studi di Milano , Bicocca, Milan, Italy

17. EPIGEN-MiChroNetwork Chromatin Seminar: “Drug targeting of the Epigenome”. January 21, 2014 Residenza Universitaria Biomedica, Universitario Santa Caterina da Siena, Pavia, Italy

18. Mathivanan Jothi, Stefano Micheloni, Giulia Ferri, Stephanie Warner, Davide Gabellini. “Dissecting the molecular mechanism responsible for DBE-T lncRNA mediated activation of gene expression in FSHD” Presented at San Raffele Scientific retreat, November 29-30, 2013 Milan, Italy, Abstract number 164A printed in the proceedings page number 120

19. MiChroNetwork Meeting. June 25, 2013 Università degli Studi di Milano , Bicocca, Milan, Italy

20. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Targeting PAX3-FKHR as a strategy for therapeutic benefit of alveolar rhabdomyosarcoma” Presented at Scientific Retreat, Roswell Park Cancer Institute, July 19-20, 2012 SUNY Geneseo, Geneseo, NY 14454 Abstract printed in the proceedings page number 25

21. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Targeting PAX3-FKHR as a strategy for therapeutic benefit of alveolar rhabdomyosarcoma” Presented at 2012 New Directions in Biology and Disease of Skeletal Muscle Conference, June 17-21, 2012 New Orleans, Louisana, USA Abstract number 122 printed in the proceedings page number 93

22. Asoke K. Mal, Biswanath Chatterjee, Mathivanan Jothi, Munmun Mal and Min-Hyung Lee. “p38-alpha MAPK relives epigenetic gene silencing to endorse the skeletal muscle differentiation program” Presented at 2012 New Directions in Biology and Disease of Skeletal Muscle Conference, June 17-21, 2012 New Orleans, Louisana, USA Abstract no 91 printed in the proceedings page number 77

23. 1st Annual Annual WNYSTEM Symposium June 2, 2012 Hauptman Woodward Medical Research Institute, 700 Ellicott Street Buffalo, New York 14203-1102 USA

24. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Targeting PAX3-FKHR as a strategy for therapeutic benefit of alveolar rhabdomyosarcoma” Presented at Scientific Retreat, Cell Stress and Biophysical Therapies Program & Cell Stress Biology, May 6-7, 2012 Holiday Inn, Grand Island, NY 14072 Abstract printed in the proceedings page number 35

25. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Targeting PAX3-FKHR as a strategy for therapeutic benefit of alveolar rhabdomyosarcoma” Presented at 4th Annual Postdoc Research Symposium, April 16th, 2012 Center for Tomorrow, North Campus, University at Buffalo, Buffalo, NY 14260 Abstract number 20 printed in the abstracts page number 10

26. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Transcriptionally inactive PAX3-FKHR fails to induce ARMS cells differentiation” Presented at 2010 Postdoc Research Symposium, June 29th, 2010 Roswell Park Cancer Institute, Buffalo, NY 14263 Abstract number 27 printed in the abstracts page number 28.

27. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Transcriptionally inactive PAX3-FKHR fails to induce ARMS cells differentiation” Presented at 2010 Postdoc Research Symposium, June 8th, 2010 Center for Tomorrow, North Campus, University at Buffalo, Buffalo, NY 14260 Abstract number 16 printed in the abstracts page number 8.

28. Mathivanan Jothi, Charles Keller, Asoke K. Mal. “Transcriptionally inactive PAX3-FKHR fails to induce ARMS cells differentiation” Presented at the AACR 101 annual meeting Apr 17 to 21, 2010 Walter E. Washington Convention center, Washington, DC. Late-Breaking Abstracts page no. 6 Cancer Res 2010; 70(8 Suppl): Abstract number LB-20.

29. Epigenetic Mechanisms in Health and Disease October 22 - 23, 2009 MaRS Center Auditorium, 101 College St., Toronto, Canada

30. K Rohini, J Mathivanan, B Anandh, ML Gope and R Gope. Presented a paper entitled “Altered expression and phosphorylation of p53 gene product in human brain tumors” at the XXXI All India Cell Biology Conference and Symposium on Stem Cells: Application and Prospect. The Conference was sponsored by Indian Society of Cell Biology and Center of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi 221 005. The conference was held in Banaras Hindu University, Varanasi, Uttar Pradesh, on 14th to 16th December, 2007; Abstract number Oral – 8, printed in the conference proceeding on page 37

31. J. Mathivanan, K. Rohini, PD. Antony Herold Prabhu, R. Thomas, ML. Gope, B. Anandh and R. Gope. Alteration of retinoblastoma (RB1) gene in human brain tumors. Presented at the 29th All India cell biology conference, Lucknow, India. January 17-20, 2006. Abstract number OP-24 printed on proceedings page no. 184

32. K. Rohini, J. Mathivanan, PD. Antony H Prabhu, R Thomas, ML Gope, B anandh and R Gope. Deregulation of the tumor suppressor gene p53 in human brain tumors. Presented at the 29th All India cell biology conference, Lucknow, India. January 17-20, 2006. Abstract number PP-108 printed on proceedings page no. 189

33. J. Mathivanan, K. Rohini, PD. Antony Herold Prabhu, R. Thomas, ML. Gope, B. Anandh and R. Gope. Molecular studies on the tumor suppressor gene RB1 in human brain tumors. Presented at the 74th Society of Biological Chemists (India) conference, Lucknow, India. November 7-10, 2005. Abstract number P15 printed on proceedings page no. 101

34. K. Rohini, J. Mathivanan, PD. Antony Herold Prabhu, R. Thomas, ML. Gope, B. Anandh and R. Gope. Molecular studies on the tumor suppressor gene p53 in human brain tumors. Presented at the 74th Society of Biological Chemists conference, Lucknow, India. November 7-10, 2005. Abstract number P14 printed on proceedings page no. 101

35. PD. Antony Herold Prabhu, J. Mathivanan, K. Rohini, R. Thomas, B. Chandramouli and R. Gope. Structure and expression of p53 gene and altered phosphorylation of p53 protein in human vestibular schwannomas. Presented at the 30th FEBS congress and 9th IUBMB conference. July 2-7, 2005, Budapest, Hungary. Abstract number N3-036P printed on proceedings page no 34.

36. R. Thomas, J. Mathivanan, K. Rohini, PD. Antony Herold Prabhu, D. Sivakumar, PN. Jayakumar, B. Indra Devi, S. Satish, KVR. Sastry and R. Gope. Deregulation of the tumor suppressor gene, retinoblastoma (RB1) in human vestibular schwannomas. Presented at the “Genes, evolution and complex diseases, an international symposium on human origins and genetics” February 17-19, 2005, held at the National Center for Biological Sciences, Bangalore 560065, India. Abstract number 27, printed in the proceedings pages 76-77

37. PD. Antony Herold Prabhu, Rohini, R. Thomas, J. Mathivanan, BA. Chandramouli, and R. Gope. Molecular studies on the p53 gene locus in Human acoustic tumors. Presented at the XXVII All India Cell Biology Conference & Symposium, Frontiers in Biomedical Research and Technology, January 7-10, 2004, University of Pune, Pune, India. Abstract number 01 printed in the proceedings page 33.

38. R. Thomas, PD. Antony Herold Prabhu, J. Mathivanan, Rohini, KVR. Sastry and R. Gope. Molecular studies on the tumor suppressor gene RB1 in human acoustic tumors. Presented at the 10th Congress of Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), Indian Institute of Science, Bangalore, India. December 7-11, 2003. Abstract number P17-08 printed in the proceedings page 115

39. PD. Antony Herold Prabhu, R. Thomas, Rohini, J. Mathivanan, BA. Chandramouli and R. Gope. Molecular analysis of the tumor suppressor gene p53 in human acoustic tumors. Presented at the 10th Congress of Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), Indian Institute of Science, Bangalore, India. December 7-11, 2003. Abstract number P17-07 printed in the proceedings page 115

7. Membership in societies:

1. Active member, American Association of Cancer Research (AACR)

2. Advisory Board/council member, FOCUS ON RHABDO-a community focused on finding the cure for rhabdomyosarcoma

3. Member, The Epigenetics Society

4. Life member, Indian Society of Human Genetics (ISHG)

5. Life member, Indian Society of Cell Biology (ISCB)

6. Life member, society of Biological Chemists (SBC), India

8. Reviewer

Journal of Cancer Therapeutics, Lifesciences, Journal of Cellular Physiology and various funding agencies.

9. Funded projects

|Title |Funding agency |Amount |Duration |

|Intramural |

|Generation of BoxB-RNA tethering system to study gene |Bharathiar University |Rs. 1,00,000 |2015-16 |

|regulatory noncoding RNAs | | | |

|Extramural |

|Characterization of long non-coding RNA (lncRNA) DBE-T and |Dulbecco Telethon |Euro 105,000 |2013-2014 |

|chromatin modifier ASH1L interaction during normal and |Foundation, Italy | | |

|abnormal muscle differentiation | | | |

|Startup Research Grant |UGC |Rs. 6,00,000 |2015-2017 |

|Exploring the Roles of Cytoskeletal protein in Muscle |SERB/DST |Rs. 43,00,000 |2017-2020 |

|Differentiation | | | |

|Evaluation of Pax3 as a Targeted Therapeutics for Pediatric|SERB/DST |Rs. 41,36,788 |2018-2021 |

|Solid Tumors | | | |

|Mentored project |

|Role of Akt isoforms in MyoD-mediated muscle |SERB/DST |Rs. 19,20,000/- |2018-2021 |

|differentiation. | | | |

10. Guided projects

Master dissertation

1. Molecular cloning of Myogenic transcription factor Myf5 cDNA into retro viral vector. – Ms.Shanmugapriya, 2020

2. Molecular cloning of introns flanking metavinculin exon contains potential Rbfox binding motif. – Mr. Carmel Jerone Raj, 2020

3. Molecular cloning of metavinculin introns contain potential binding sites for splicing factor Rbfox. – Mr. Nishad Keethedath, 2019

4. Generation of pCDNA3-T vector to clone PCR products - Ms. Jeena Boban, 2019

5. Cloning of myogenic factor 5 (Myf5) cDNA in mammalian Expression Vector – Ms. Arpitha R, 2019

6. Cloning of RBFOX-1 cDNA in Bacterial Expression Vector- Ms. Bhuvaneshwari A, 2018

7. Cloning of RBFOX-2 cDNA in Bacterial Expression Vector - Mr. Sourajit Das, 2018

8. Exploration of the Akt-MyoD interaction during skeletal muscle differentiation - Ms. S. Krishnaveni, 2017

9. Identification of Pax3 role in neuroblastoma - Ms. V. Kiruthika, 2017

10. Role of Master Myogenic Regulator Myf5 in ARMS cells differentiation - Ms. N. Nafia, 2016

11. Studies on the expression of proto-oncogene MYCN in ARMS cells differentiation - Ms. Susee Sudhakar 2016

12. Expression analysis of metavinculin during muscle differentiation - Ms. M. Abinayaselvi 2016

13. Exploration of the role of Akt signaling in skeletal muscle differentiation - Ms. V. Dhivya 2016

Summer training

1. Ms. Janova Anbarasi (2019) Expression of DSTY kinase during muscle cell differentiation.

2. Ms. Aparna OM (2019) Techniques in Molecular Biology.

3. Ms. Keerthana. V (2018) Techniques involved in generation and heterologous expression of RbFox1.

4. Ms. Jesintha. A (2018) Techniques involved in generation and heterologous expression of RbFox2.

5. Ms. Anjali (2017) Techniques involved in generation and identification of shRNA clones to target metavinculin.

Short term trainees

1. Ms. Bhargavi. K, Ms. Deechamma. MP, Gunjan Kapoor, Brinda Joseph

11. Reference

1. Asoke K Mal, Ph.D.

Assistant member (Clin Res)

Department of Cell Stress Biology

Roswell Park Cancer Institute

Elm & Carlton Streets

Buffalo, NY 14263 USA

Ph: 716 845 4133

Email: asoke.mal@

2. Davide Gabellini, Ph.D.

Division of Regenerative Medicine

San Raffaele Scientific Institute

DIBIT 2, 5A3-44

Via Olgettina 58

Milano, ITALY, Pin 20132

Phone: +39.02.2643.5934

+39.02.2643.5065

Fax +39.02.2643.5544

Email: gabellini.davide@hsr.it

3. Prof. Rajalakshmi Gope PhD.,

Professor and Head (Retired)

Department of Human Genetics,

National Institute of Mental Health and Neurosciences (NIMHANS),

Bangalore, Karnataka, INDIA. Pin 560029.

Phone: + 91 9980143759

Email: rlgope@

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