Assessment of Acute Oral Toxicity for Mixtures using In Silico Modeling ...
AFRL
Assessment of Acute Oral Toxicity for Mixtures Using In Silico Modeling Methods
Presented May 27, 2021 Public Meeting of the Interagency Coordinating Committee on Validation of
Alternative Methods
Work Performed by Slava Chushak, PhD and Jeffery Gearhart, PhD Presented by Matthew W. Linakis, PhD
US Air Force Research Laboratory 711th Human Performance Wing, Wright-Patterson Air Force Base, Ohio USA matthew.linakis.1@us.af.mil
Distribution A: Cleared for Public Release Case Number: MSC/PA-2021-0176
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AFRL
Disclaimers
? Opinions are those of the presenter, and not those of the Air Force, or the Department of Defense (DOD).
THE AIR FORCE RESEARCH LABORATORY
Distribution A: Cleared for Public Release Case Number: MSC/PA-2021-0176
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Outline
? Background ? Objectives ? Approach ? Results
? Analysis of Input Data ? Predictions of GHS acute oral toxicity category ? Challenges ? Impact and Conclusions ? Acknowledgements
AFRL
THE AIR FORCE RESEARCH LABORATORY
Distribution A: Cleared for Public Release Case Number: MSC/PA-2021-0176
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AFRL
Objectives
? While exposure of humans to environmental hazards often occurs with chemical mixtures, the majority of existing toxicity data and tools are for single compounds ? This is particularly pertinent given the number of unique AF-relevant mixtures used across the force.
? Therefore, our researchers evaluated the prediction of GHS acute oral toxicity category for mixtures using the additivity formula and toxicological data collected in the Integrated Chemical Environment (ICE)
THE AIR FORCE RESEARCH LABORATORY
Distribution A: Cleared for Public Release Case Number: MSC/PA-2021-0176
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AFRL
Approach
? By using available experimental data for individual ingredients, our researchers were able to calculate a GHS category for only half of the mixtures.
? The Collaborative Acute Toxicity Modeling Suite (CATMoS) was used to predict LD50 values for active ingredients without available experimental data.
THE AIR FORCE RESEARCH LABORATORY
Sourot: UN GHS Pu 'pit Boole
Distribution A: Cleared for Public Release Case Number: MSC/PA-2021-0176
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