Acute Toxin Fact Sheet - Environmental Safety, Sustainability and Risk

Acute Toxin Fact Sheet

This fact sheet is for general safety awareness. Individual Standard Operating Procedures for all experiments and processes

involving acute toxins must be developed by the laboratory.

PROPERTIES & HAZARDS

Acute toxins are especially poisonous, where even a single exposure of short duration could be lethal for some materials. There

are five categories that you may see on the safety data sheet (SDS) or bottle, Category 1 through 5, and three target areas, oral,

dermal, and inhalation. In Section 2 ¨C Hazard Identification of the SDS, any one, or a combination of the following hazard

classifications, pictograms and hazard statement key words will be listed indicating an acute toxicity hazard. More information on

material hazards can be found in complete hazard statements listed on an SDS or chemical bottle.

Hazard Classification and Category

Pictogram

Signal Word

Acute Toxicity (Oral, Dermal or Inhalation) ¨C Category 1 and 2

Fatal

Acute Toxicity (Oral, Dermal or Inhalation) ¨C Category 3

Toxic

Acute Toxicity (Oral, Dermal or Inhalation) ¨C Category 4

Harmful

Acute Toxicity (Oral, Dermal or Inhalation) ¨C Category 5

No Pictogram

May be harmful

The severity of a toxin is categorized by concentrations of the LD50 (lethal dose for 50% of an animal population) of the substance

where available testing data is listed in Section 11 - Toxicological Information on the SDS. This is the median lethality, which

means that the minimum dose to be lethal can be much less than these concentrations.

Acute Toxicity LD50 Category Ranges

Acute Toxicity Type

Category 1

Category 2

Category 3

Category 4

Category 5

Anticipated oral LD50 between 2000 and

Oral (mg/kg)

5 - 50 - 300 - ................
................

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