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In ARIES-2, 192 patients were randomized to receive 2.5 or 5 mg of ambrisentan orally once daily or placebo. Significant improvements in 6MWD at 12 weeks were shown in both ambrisentan treatment groups compared to placebo: increase of 22.2m ±82.7 from a baseline of 347m (2.5 mg); increase of 49.4m ±75.4 from a baseline of 355m (5 mg); and ... ................
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