MINI BLURB - University of Toronto



University of Toronto

Cardiovascular Sciences Collaborative Program

ACTIVITY REPORT

1998 – 1999

FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2

Tel: 416/978-0746 Fax: 416/946-5713 E-mail: cv.program@utoronto.ca

Web site: library.utoronto.ca/www/cardiosci/index.html

CONTENTS

Collaborating Departments

Executive Committee

Courses Offered

Program Sponsored Activities

- Annual Cardiovascular Scientific Day

- Medtronic Travel Award

- Bigelow Book Prize

- Ontario Student Opportunity Trust Funds (OSOTF) Award

- Lecture Series

- 2nd Annual “Cardiovascular Disease Update”

- Summer Activities

Advertising Material

- World Wide Web

Program Faculty

Program Students

Convocated Students/Follow-up

Student Achievements

Director’s Comments

Publications

- Students

- Faculty

Acknowledgements

The Cardiovascular Sciences Collaborative Program has continued to look to the millennium to develop student participation and through forged links strengthen the experience of all Program participants for both faculty and students. By solidifying the Program’s financial base through interest available from endowments, industry sponsorship, and individual departmental support, the Program is in a more secure position. It is with excitement and anticipation we look to the year 2000 as we are now better placed to provide an outstanding value added graduate training experience to those who wish to specialize in cardiovascular sciences.

The Program office is now consolidated on campus in the FitzGerald Building as we recently closed the satellite office. Day-to-day functions of the Program are handled by the Program Director, Dr. C. Wittnich, and the Program Administrator, Victoria Simpson, with the guidance of the Executive Committee.

Thanks to all of the faculty, students, and participants in our activities for another successful year!

Dr. Carin Wittnich

COLLABORATING DEPARTMENTS

Faculty: Medicine

Physical Education and Health

Clinical: Department of Medicine

Department of Surgery

Department of Anaesthesia

Graduate: Department of Clinical Biochemistry

Department of Community Health

Department of Exercise Sciences

Department of Pharmacology

Department of Physiology

Department of Rehabilitation Science

Institute of Medical Science

Laboratory Medicine and Pathobiology

Other: The Centre for Cardiovascular Research

Institute of Biomedical Engineering

EXECUTIVE COMMITTEE

The Executive Committee consists of a representative from each collaborating department as well as a student representative.

Dr. C. Wittnich (Director)

Dr. M. Plyley (Exercise Science)

Dr. M. Rabinovitch (Lab. Med. Pathobiology)

Dr. D.H. Osmond (Physiology)

Dr. R.D. Weisel (IMS)

Dr. C-C. Liew (CCR)

Dr. R.I. Ogilvie (Pharmacology)

Dr. M. Ojha (IBME)

Dr. D. Cheng (Anaesthesia)

Dr. S. Thomas (Rehabilitation Science)

Dr. Andrew Campbell (Student Representative)

COURSES OFFERED

EXS5508H Cardiovascular Disease and Exercise (Exercise Science)

MSC3060H* Advanced Topics in Cardiovascular Sciences I (IMS)

MSC3061H* Advanced Topics in Cardiovascular Sciences II (IMS)

LMP1015H Vascular Pathobiology (Lab. Med. Pathobiology)

PCL1006Y Cardiovascular Pharmacology (Pharmacology)

PSL1029H Advanced Course in Cardiovascular Regulation (Physiology)

PSL1038H Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments (Physiology)

PSL1060H Developmental Cardiovascular Physiology (Physiology)

LMP1407H From Bench to Bedside: Design, Measurement, and Analysis for Clinical Investigators (Lab. Med. Pathobiology)

LMP1503H Signal Transduction Pathways in Normal and Diseased Tissue (Lab. Med.

Pathobiology)

LMP1504H Biochemistry, Molecular Biology of Cardiovascular Diseases (Lab. Med.

Pathobiology)

BME1448H Cardiovascular Fluid Mechanics (IBME)

JEB1365H Ultrasound: Theory and Applications in Biology and Medicine (IBME)

JTC1331H Biomaterials Science (IBME)

* Core Courses for PhD Trainees

PROGRAM SPONSORED ACTIVITIES

Annual Cardiovascular Scientific Day - May 20, 1999

The Annual Scientific Day, hosted by the Cardiovascular Sciences Collaborative Program, University of Toronto and the Centre for Cardiovascular Research (CCR), is organized to bring together faculty and students interested in cardiovascular sciences. The aim is to provide an update in the frontiers of cardiovascular science and each symposium focuses on either clinical or basic science research. Attendees are encouraged to actively participate, either in the form of a poster presentation or oral discussion, promoting cross-fertilization of ideas and assisting research direction within our own cardiovascular community.

The scientific day was held at the Granite Club where over 350 registrants enjoyed a pleasant day of camaraderie, excellent science, and good food. This year the focus was on “Cardiovascular Care at the Millennium”. A central featured symposium exploring the evaluation of this care consisted of a number of speakers both local and invited. Dr. David Alter, Department of Medicine, ICES and Cardiology, spoke on “Trends and Variations in Cardiovascular Disease in Ontario-Highlights from the Cardiovascular Atlas”. Dr. Geoffrey Anderson, Associate Professor, Health Administration, University of Toronto, discussed “Research on Public Report Cards: Good Science or Good Politics?”. Dr. Jacques LeLorier, Professor, Depts of Medicine and Pharmacology, University of Montreal was the Annual Isadore E. Smith Lecturer, hosted by the CCR. He discussed “The Role of Patients and Healthcare Professionals in the Use and Misuse of Cardiovascular Drugs”. This session was followed by a refreshment break and then the focus shifted to therapeutic advances at the millennium. Topics covered included presentations on “CPAP for Advanced Heart Failure” (Dr. T.D. Bradley), “Off-pump Bypass” (Dr. Y. Leclerc), “Cell-based Research in Cardiac Xenotransplantation” (Dr. J.G. Coles) and “Gene Therapy for Paediatric Congenital and Adult Cardiovascular Disease” (Dr. M. Rabinovitch). After a very pleasant lunch, the afternoon began with Poster Presentations by our graduate and postdoctoral trainees. This was followed by an afternoon session which covered the “Approaches to Atherosclerosis at the Millennium”. This was highlighted by presentations on “Genetic Dissection of Atherosclerosis” (Dr. R.A. Hegele-Annual Guest Speaker), “Homocysteine and Atherosclerosis” (Dr. J.D. Spence-Annual Guest Speaker), “Inflammatory Heart disease and Autoimmunity: Chlamydia and Atherosclerosis” (Dr. J. Penninger), and “Anti-Atherosclerotic Properties of Wine” (Dr. D.M. Goldberg).

There were 33 abstracts submitted for the poster session. A panel of judges preselected six poster finalists who were also asked to give a short oral presentation during a poster walkabout. An additional hour of poster viewing was available during the breaks and over lunch. These posters highlighted our cardiovascular trainees in their particular area of interest. Poster prizes, in the form of textbooks, were again generously provided by Lippincott-Ravin Publishers.

1st Prize - A.I.M. Campbell ~~ Angiogenic therapy for pulmonary hypertension (Supervisor: Dr. D.J. Stewart)

2nd Prize - K.S. Bandali ~~ Neonatal hemodynamic & metabolic responses to hyperoxia

(Tied) (Supervisor: Dr. C. Wittnich)

2nd Prize - P.W.M. Fedak ~~ Predictors of risk for coronary bypass with severe LV

(Tied) dysfunction (Supervisor: Dr. R.D. Weisel)

Continuing medical education credits were issued for this meeting; continuing the high quality of scientific content (6.5 hours of category 1 credit toward the AMA Physicians Recognition Award and 8.45 MOCOMP credits for the Royal College of Physicians and Surgeons of Canada).

My thanks are extended, once again, to industry for their continued financial support and generousity which is so essential to the success of this meeting. Major sponsorship included Hoechst Marion Roussel Canada, Key Pharmaceuticals, and Merck Frosst Canada Inc. Because of their support, we were able, once again, to provide an open registration and complimentary luncheon.

Students who completed the Cardiovascular Sciences Collaborative Program were recognized at the Awards ceremony and included Newsha Azizi, MSc (Supervisor: Dr. U. Ackermann), Warren Ball, MSc (Supervisor: Dr. R-K. Li, Andrea Burry, MSc (Supervisor: Dr. M. Rabinovitch), Hani Najm, MSc (Supervisor: Dr. C. Wittnich), and Catherine Mason, PhD (Supervisor: Dr. M. Rabinovitch).

The Annual Cardiovascular Scientific Day continues to be the highlight of our academic year!

Medtronic Travel Award

Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 1998:

Rohan Shahani: Myocardial Dysfunction following Repair of Ruptured Abdominal Aortic Aneurysms. 71st Scientific Sessions of the American Heart Association, November 1998 (Supervisor: Dr. Thomas Lindsay, IMS).

Shona Torrance: Ischemic Time in Immature Hearts: Duration Does Not Predict All Aspects of Functional Recovery. Annual Meeting of the Canadian Cardiovascular Society, October 1998 (Supervisor: Dr. C. Wittnich, IMS).

Jack Wallen: Does Gender Affect Metabolic Potential in Hypertrophied Hearts? Annual Meeting of the Canadian Cardiovascular Society, October 1998 (Supervisor: Dr. C. Wittnich, Physiology)

Note: No applications were received for the Spring 1999 competition.

Bigelow Book Prize

The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin”. This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honour a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow -- curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care.

1995 - Dr. John S. Ikonomidis

1996 - Ms. Shona M. Torrance

1997 - Dr. Vivek Rao

1998 - Dr. Bryce Cowan

1999 – Dr. Gideon Cohen

Ontario Student Opportunity Trust Funds (OSOTF) Award

The OSOTF award refers to a class of awards which have resulted from Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria, including excellence in science and academic performance, that must be adhered to. One competition will be held per academic year, except for the inaugural competition year where two competitions were held.

The applications are handled centrally through the Faculty of Medicine’s, Research Office. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee; chaired by Dr. D. Cheng. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine) where the final decision is made. Of this years eligible submissions, all were deemed meritorious and the awards were allocated equitably to the winners as follows:

Fall 1998 Competition

Karim Bandali, PhD, Dept. of Physiology

Jack Wallen, PhD, Dept. of Physiology

Spring 1999 Competition

Karim Bandali, PhD, Dept. of Physiology

Jack Wallen, PhD, Dept. of Physiology

Cathy Boscarino, MSc, Dept. of Physiology

Lecture Series

For this academic year the lecture series was focused in two main areas: Heart Function and Vascular. A number of interesting speakers, once again, contributed their time and knowledge. Both these areas were covered from the perspective of whole body and organ to the molecular level including genetics, with a particular emphasis on bridging basic science and clinical approaches to these areas.

2nd Annual “Cardiovascular Disease Update”

The 2nd Annual Cardiovascular Disease Update was successfully held on February 27, 1999 at the Weston Prince Hotel, Toronto. This annual CME event was made possible by the generous sponsorship of Bristol-Myers Squibb. The purpose of this half day event is to provide clinical insight into the diagnosis and treatment of current cardiovascular disease from a bench-to-bedside perspective. This year the focus was on issues relating to women and heart disease, hypertension and drug therapies. Each session was accompanied by audience discussion which continued informally during the buffet luncheon. The meeting was accredited for 4 Mainpro-MI credits and 5.2 MOCOMP credits and was attended by 121 Family Physicians and Internists from across Toronto. The speakers and topics were:

Dr. Beth Abramson, Lecturer, Dept. of Medicine, University of Toronto

Cardiologist and Director, Women’s Cardiovascular Health, St. Michael’s Hospital

“Diagnosis of Chest Pain in Women: Looks May Be Deceiving”

Dr. Paul Oh, Lecturer, Clinical Pharmacology, University of Toronto

Clinic Director, Cardiovascular Assessment & Rick Evaluation, Sunnybrook Health Science Centre

“Caveats & Pearls – What the Family Practitioner Needs to Know When Following the Post-MI, CHF, or Angina Patient”

Dr. David Mendelssohn, Associate Professor of Medicine, University of Toronto

Nephrologist and Director of Peritoneal Dialysis, St. Michael’s Hospital

“Diabetes and Hypertension: A Potpourri of New Information”

Dr. Jules Yt Lam, Associate Professor of Medicine, University of Montreal

Cardiologist, Montreal Heart Institute

“Differentiation of the Statins”

Summer Activities

The Collaborative Program, along with the Division of Cardiac Surgery, Department of Surgery, ran another very successful summer program. Applicants included undergraduate and medical school students from the University of Toronto as well as other universities. The Collaborative Program provided a number of summer scholarships to help students who were unable to procure funding. Over the course of the summer, seminars were presented by graduate students currently enrolled in the Collaborative Program and covered a range of topics with both clinical and basic science relevance. As well, the summer students were given the opportunity to present their summer work. An “end-of-summer” luncheon is held for both faculty and students.

This highly successful program is enjoyed by all who participate.

ADVERTISING MATERIAL

World Wide Web

The Cardiovascular Sciences Collaborative Program continues to maintain its own web site under the Faculty of Medicine. This web site is updated regularly and is continually undergoing expansion. Please check out our site at library.utoronto.ca/www/cardiosci/index.html to learn more about cardiovascular sciences. The site is updated at faculty renewal and whenever relevant changes occur. Links continue to be built with other relevant cardiovascular sites.

Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.

Other material that continues to give the Program exposure includes the brochure, the Scientific Day pamphlets and posters, various industry sponsored seminars, and the Lecture Series notices posted on campus. Collaborating departments also display and distribute the Program brochure.

PROGRAM FACULTY

Faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS status.

FULL: U. Ackermann, L. Adamson, P. Backx, C.E. Bayliss, D. Bradley, F. Coceani, J. Coles, J. Edelson, C.R. Ethier, J.S. Floras, C. Forrest, S. Fremes, J.M. Goodman, A.I. Gotlieb, K.W. Johnston, P.G. Kalman, F. Keeley, B.L. Langille, H. Lenskyj, G.F. Lewis, C-C. Liew, P. Liu, P. McLaughlin, D.A.G. Mickle, L. Mickleborough, R.I. Ogilvie, M. Ojha, D.H. Osmond, T. Parker, M.J. Plyley, M. Rabinovitch, M. Sefton, I. Sherman, A.S. Slutsky, M.J. Sole, G. Steiner, D.E. Stewart, D.J. Stewart, S.G. Thomas, P. Walker, R.D. Weisel, G. Wilson, C. Wittnich, T-W. Wu, E.L. Yeo

ASSOCIATE: M. Bendeck, D. Brooks, E. Conway, P. Dorian, L.S. Goodman, J. Irvine, T. Lindsay, M. Locke, J. Parker, N.A. Shaikh, R. Wald

AFFILIATE: R.J. Burns, J. Butany, D. Cheng, D. Courtman, C.M. Feindel, J. Fisher, R-K. Li, R. McLean, P. Murphy, L. Schwartz

We would like to wish Dr. E. Conway all the best in his new position in Belgium. As well, best wishes to Dr. F. Coceani whose base of operation is now in Italy but he has maintained his ties with the University of Toronto.

Our thoughts and prayers go out to the family of Dr. Adelman whose life’s journey ended this past May.

PROGRAM STUDENTS

Student Supervisor Degree Department

Karim Bandali C. Wittnich PhD Physiology

Michael Borger R. Weisel PhD IMS

Cathy Boscarino C. Wittnich MSc Physiology

Andrew Campbell D. Stewart PhD IMS

Gideon Cohen R.D. Weisel PhD IMS

Ian Copland L. Adamson MSc Physiology

Kyle Cowan M. Rabinovitch PhD Pathology

Sonia Katyal S. Thomas MSc Rehab Med

Negin Liaghati-Nasseri S. Fremes MSc IMS

Vaska Micevski D. Stewart PhD IMS

Stephen Milone J. Parker MSc Pharmacology

Stacy O’Blenes M. Rabinovitch MSc Pathology

Rohan Shahani T. Lindsay MSc IMS

Shona Torrance C. Wittnich PhD IMS

Dimitra Trambakoulos D. Osmond MSc Physiology

Jack Wallen C. Wittnich PhD Physiology

Mohammed Warsi P. Liu MSc IMS

CONVOCATED STUDENTS/FOLLOW-UP

Newsha Azizi, MSc, Dept. of Physiology (Supervisor, Dr. U. Ackermann) has continued with her graduate training as a PhD student.

Warren Ball, MSc, Institute of Medical Science (Supervisor: Dr. R-K. Li) has been accepted into medical school.

Andrea Burry, MSc, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch) has been accepted into medical school.

Hani Najm, MSc, Institute of Medical Science (Supervisor: Dr. C. Wittnich) has accepted a position of Associate Professor in Surgery at the King Saudi University.

Catherine Mason, PhD, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch) has returned to medical school at the University of Toronto.

STUDENT ACHIEVEMENTS

Karim Bandali Ontario Student Opportunity Trust Fund (OSOTF) Award

The Centre for Cardiovascular Research Scientific Day Featured Poster/Winner

Michael Borger Edward Christie Stevens Fellowship, University of Toronto

Graham Campbell Fellowship, University of Toronto

Merit Scholarship, Institute of Medical Science, University of Toronto

PSI Resident Research Award

J.C. Laidlaw Award of Excellence, Institute of Medical Science, University of Toronto

First Prize, Terrence Donnelly Canadian Cardiac Surgery Resident Research Day

Catherine Boscarino John Hepburn Award, Dept. of Physiology, University of Toronto

University of Toronto Fellowship, Dept. of Physiology

Pharmaceutical Manufacturers Assoc. of Canada/Medical Research Council (MRC) Summer Scholarship

Gideon Cohen Edward Christie Stevens Fellowship, University of Toronto

Harrison Teaching Award, Dept. of Surgery, Sunnybrook Health Science Centre

Kyle Cowan Tuition Scholarship, Hospital for Sick Children

Emmanuel Farber Award, Dept. of Laboratory Medicine and Pathobiology Research Day

Research Traineeship, Heart and Stroke Foundation of Canada(declined)

Doctoral Research Award, Medical Research Council of Canada and K.M. Hunter Awardee Distinction

Ontario Graduate Scholarship(declined)

Doctoral Fellowship, University of Toronto Open

Dutkevich Research Travel Award

Worthington Award for Travel

Bio-Rad Awardee

Robert Disenhouse Cardiac Science Award

Featured Poster, Cardiovascular Sciences Collaborative Program Research Symposium

Park Davis Award

Negin Liaghati- University of Toronto Open Scholarship

Nasseri

Vaska Micevski Nursing Research Fellowship (PhD), Heart and Stroke Foundation of Canada

North American Menopause Society/Wyeth-Ayerst Nurse Practitioner

Stacy O’Blenes The Terrence Donnelly Cardiac Resident Research Day Wilfred Bigelow Prize

First Prize, Surgical Services Basic Science Research Competition, Hospital for Sick Children

Rohan Shahani Second Prize, Resident/Graduate Student Oral Presentation Seminar, University of Toronto Trauma Research Day

Medtronic Travel Award, Cardiovascular Sciences Collaborative Program

IMPRA/BARD Annual Research Award, Canadian Society of Vascular Surgeons

Shona Torrance Research Fellowship, Ontario Ministry of Health

Medtronic Travel Award, Cardiovascular Sciences Collaborative Program

Jack Wallen Teaching Award, Dept. of Physiology, University of Toronto

Ontario Student Opportunity Trust Funds (OSOTF) Award, University of Toronto

Medtronic Travel Award, Cardiovascular Sciences Collaborative Program

Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship

Mohammed Warsi Ontario Graduate Scholarship in Science and Technology

Pfizer Award, Eastern Student Research Forum, University of Miami

University of Toronto Open Scholarship

DIRECTOR’S COMMENTS:

In its’ seventh year, the Cardiovascular Sciences Collaborative Program (CSCP) continues to grow and evolve. During this academic year we had our 7-Year OCGS review which went resoundingly well, and resulted in a renewal mandate. The CSCP also continues to develop new liaisons with departments expressing an interest in cardiovascular sciences. Specifically, the Department of Rehabilitation Science was welcomed to the program.

The CSCP also came to a crossroads this year. On the one hand there was the successful OCGS review endorsing our effort. On the other hand it became clear we had reached the maximum capacity of what the Program could accomplish with existing financial and personnel resources. For the Program to continue to grow, a fully committed administrative individual, focused on the initiatives of the Program, is critical. To secure this, a stable financial infrastructure is needed to fund this individual. All activities depend on this basic administrative need which could no longer be met without a fully designated individual to handle the day-to-day administration. After lengthy negotiations with a number of parties this issue was addressed.

The following graph represents the enrolment figures. It can be seen that during the current academic year we had 13 Masters and 9 PhD trainees active in the program. There was a significant number of our trainees who completed and convocated which, this year for the first time, exceeded recruitments. With the Program’s resounding endorsement by the SGS and OCGS, it is clear our focus needs to be student recruitment. To date, no targeted efforts have been made but we have relied on word of mouth and student satisfaction. This approach, as can be seen from previous years figures, has been quite successful – resulting over the years in a 4-fold increase enrolment. However, the time has come to expand our base and share the potential of this value added experience with all students through a more aggressive information and recruiting campaign. Up until and including this year, this was not possible as the Program did not have a fully committed administrative individual with the time to launch and maintain such an effort. With this issue reaching a potential resolution, we are now in a position to initiate a student recruitment drive.

I continue to meet with the students on an annual basis to ensure continued satisfaction with the program. From these interviews it was decided to expand the student representation on the Executive Committee to two (a junior student who has recently started their training and a senior student). These students will also organize the various student activities for the Program. The postgraduate follow-up illustrated that the graduates of this past year have gone on to pursue either academic or research careers. (see Convocated section of Report). As part of the tradition, bound copies of each graduating students' thesis is kept in the program office.

The CSCP awards programs helped support a number of our trainees. The Medtronic Travel Award monies made it possible for a number of students to attend scientific meetings and present their work. As well, the OSOTF bursary monies provided much needed financial relief to a number of deserving students in the Collaborative Program. These funds will be available on an annual basis to help those with demonstrated academic and research excellence that are in financial need. Corporate sponsors such as Bristol-Myers-Squibb and Merck Frosst Canada continue to be recognised for their outstanding annual support of graduate education in the cardiovascular sciences area at the University of Toronto.

The Bigelow Book Prize is awarded in recognition of an outstanding graduate student in the program and is the most prestigious student award given annually. Apart from the annual luncheon, a plaque is now planned to commemorate this annual event.

Due to the popularity of course MSC 3060/3061, it has been redesigned into 4 modules. These new modules will be submitted to the SGS for approval which will create new course designations. Thus, once approved, there will be 4 courses on advanced topics in cardiovascular sciences for our trainees to select from: MSC3060 - Cellular and Molecular Mechanisms, MSC3061 - Hormones & the Cardiovascular System, MSC3062 - Heart Function, MSC3063 - Vascular. Continued frequent review of these courses will occur to ensure that current technologies and research foci, that are leading edge, are represented. This is critical if they are to serve as our flagship courses for our trainees.

The second annual CV Update was again jointly run with the generous support of Bristol Myers Squibb. This half-day event provided a clinical update and insights to interested trainees, specialists and general practitioners in the cardiovascular field. Each year a different focus will be highlighted (see appropriate section in report)

We look forward to working with the newly created Heart & Stroke/Richard Lewar Centre of Excellence (HSRLCE) at the University of Toronto. The Heart & Stroke Foundation of Ontario and the family of Richard Lewar jointly donated $13 million to establish this cardiovascular Centre. The purpose of this Centre is to bring cutting edge cardiovascular research together at the University and become an international leader of cardiovascular research. A search was conducted and Dr. Peter Liu was established as Director. The Centre’s mandate includes research in cardiovascular disease, focusing on the prevention and cure of atherosclerosis, heart failure and congenital heart disease. There will also be a transgenic physiology core facility at the FitzGerald Bldg. With the Collaborative Program’s role in education and the Centre’s role in research, hopefully we can take advantage of these strengths by avoiding duplication and providing an outstanding second-to-none cardiovascular initiative. This relationship will be further explored in the upcoming year.

For the 1999-2000 academic year, we plan to continue our current activities and pursue the following priorities:

1. Firm up a 5-year plan for the program.

2. Actively recruit students to the program.

3. Create a Student Guidebook with course listings to help selection.

4. Hold the first Student Research Day, February 2000.

5. Target clinical residents doing 1-2 years of research for recruitment into formal graduate

program where appropriate.

6. Further develop CME programs.

7. Further secure infrastructure support via endowments.

PUBLICATIONS – STUDENTS

Borger MA, Buth KJ, Rao V, Bozinovski J, Liaghati-Nasseri N…Fremes SE: Multiple arterial grafts: Radial versus right internal thoracic arteries. Circulation, 1998;98:II7-II14.

Borger MA, Peniston CM, Weisel RD, Ivanov J, Rao V, Cohen G, Feindel CM, David TE: Decreasing incidence of stroke during valvular surgery. Circulation, 1998;98:II137-II143.

Borger MA, Weisel RD: Calcium channel blockers in myocardial and cerebral ischemia: A clinician’s review from bench to bedside. Can J Cardiol, 1999;15:333-340.

Christakis GT…Fremes SE, Rao V, Cohen G, Borger MA, Panagiotopoulous KP, Weisel RD: Inaccurate and misleading valve sizing: Proposed standards for valve size nomenclature. Ann Thorac Surg, 1998;66:1198-1203.

Cohen G, Fremes SE, Feder-Elituv R, et al: A phase II randomized trial of adenosine cardioplegia. Circulation, 1998;98:II225-II233.

Cohen G, Shirai T, Weisel RD, Rao V…Borger MA, Li R-K, Mickle DAG: Optimal myocardial preconditioning in a human model of ischemia and reperfusion. Circulation, 1998;98:II184-II196.

Cowan KN, Jones PL, Rabinovitch M: Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis. Circ Res, 1999;84:1223-1233.

Mason C, Bigras J, O’Blenes SB… Rabinovitch M: Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nature Med, 1999;5:176-182.

Micevski V: Myocarditis: The use of molecular technology for the detection of enteroviral ribonucleic acid in myocarditis. J Cardiovasc Nurs, 1999;13(3):78-90.

O’Blenes SB, Ross DB, Nanton MA, Murphy DA: Atrioventricular septal defect with Tetralogy of Fallot: Results of surgical correction. Ann Thorac Surg, 1998;66:2078-2084.

Rao V, Komeda M, Weisel RD, Cohen G, Borger MA, David TE: Should the pericardium be closed routinely after heart surgery? Ann Thorac Surg, 1999;67:484-488.

Rao V, Merante F, Weisel RD, Shirai T, Ikonomidis JS, Cohen G, et al: Insulin stimulates pyruvate dehydrogenase and protects human ventricular myocytes from simulated ischemia. J Thorac Cardiovasc Surg, 1998;116:485-494.

Rao V…Fremes SE, Bhatnagar G, Cohen G, Borger MA, Abouzahr L, Goldman BS: A novel comparison of stentless versus stented valves in the small aortic root. J Thorac Cardiovasc Surg, 1999;117:431-438.

PUBLICATIONS – FACULTY

Abramson BL, Ando S, Notarius CF, Rongen GA, Floras JS: Effect of atrial natriuretic peptide on muscle sympathetic activity and its reflex control in human heart failure. Circulation 1999;99:1810-1815.

Anderson JL…and the AVID Investigators (P. Dorian-Investigator): Design and results of the antiarrhythmics vs implantable defibrillators (AVID) registry. Circulation 1999;99:1692-1699.

Andrews TC, Parker JD, et al: Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction. J Am Coll Card 1998;32:1680-1686.

Ariel AP, Furlott HG, Chapman KR, Slutsky AS, Webster P, Zamel N, Tarlo SM: Effect of high dose inhaled acetic acid on airway responsiveness in Fisher rats. Can Resp J 1998;5(5):349-354.

Arthur HM, Garfinkel PE, Irvine J: Development and testing of a new hostility scale. Can J Cardiol 1999;15:539-544.

Asokumar B, Cheng DCH, et al: Pharmacokinetics of doxacurium chloride during normothermic and hypothermic cardiopulmonary bypass surgery. Can J Anaesth 1998;45:515-520.

Azevedo ER, Newton GE, Parker JD: Cardiac and systemic sympathetic activity in response to clonidine in human heart failure. J Am Coll Card 1999;33:186-191.

Azevedo ER, Parker JD: Parasympathetic control of cardiac sympathetic activity. Normal ventricular function versus congestive heart failure. Circulation 1999;100:274-279.

Babensee JE, Cornelius RM, Brash JL, Sefton MV: Immunoblot analysis of proteins associated with HEMA-MMA microcapsules: Human serum proteins in vitro and rat proteins following implantation. Biomaterials 1998;19:839-849.

Baker B, O’Kelly B, Szala JP, Katic M, McKessock D, Ogilvie RI, Basinski A, Tobe SW: Determinants of left ventricular mass in early hypertension. Am J Hyperten 1998;11:1248-1251.

Ball AMM, Sole MJ: Oxidative stress and the pathogenesis of heart failure. Cardiol Clinics 1998;16(4):665-675.

Ballyk PD, Walsh C, Butany J, Ojha M: Compliance mismatch may promote artery/graft intimal hyperplasia by altering suture-line stresses. J Biomechanics 1998;31:229-237.

Bandali KS, Ackermann U: Are prostaglandins involved in ANP mechanisms of cardiovascular control? Can J Physiol Pharmacol 1999;77:211-215.

Bayer IM, Adamson SL, Langille BL: Atrophic remodeling of the artery-cuffed artery. Arteriosclerosis, Thrombosis and Vasc Biol 1999;19:1499-1505.

Bayliss CE, Ackermann U: Edith. Structure/Function, Case 1. Copyrighted, UofT Fac. Med. 41 pages, 1998.

Bayliss CE, Cormack DH, Baker RR: Week 11 Syllabus. Structure/Function. Copyrighted, UofT Fac. Med. 107 pages, 1998.

Bayliss CE, Cormack DH, Baker RR: Week 12 Syllabus. Structure/Function. Copyrighted, UofT Fac. Med. 83 pages, 1998.

Bayliss CE, Cormack DH, Baker RR: Week 13 Syllabus. Structure/Function. Copyrighted, UofT Fac. Med. 84 pages, 1998.

Bayliss CE, Cormack DH, Baker RR: Week 14 Syllabus. Structure/Function. Copyrighted, 46 pages, 1998.

Bayliss CE, Goldlist BJ, Senn JS: Mrs. Lively. Structure/Function, Case 2. Copyrighted, UofT Fac. Med. 50 pages, 1998.

Bayliss CE, Goode RC, Duffin J, Senn JS: Bart Giamatti. Structure/Function, Case 3. Copyrighted, UofT Fac. Med. 42 pages, 1998.

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Borger MA, Weisel RD: Calcium channel blockers in myocardial and cerebral ischemia: A clinician’s review from bench to bedside. Can J Cardiol 1999;15:333-340.

Borges A, Tsushima RG, Backx PH: Antibodies against Tityus discrepens venom do not abolish the effects of Tityus serrulatus venom on the rat sodium and potassium channels. Toxicon 1999;37(6):867-881.

Bourassa MG…Schwartz L, et al: Is a strategy of intended incomplete PTCA revascularization acceptable in patients who are candidates for CABG? The Bypass Angioplasty Revascularization Investigation (BARI). J Am Coll Cardiol 1999;33:1627-1636.

Boutitie F…Dorian P, Frangin G, and the EMIAT & CAMIAT Investigators: Amiodarone interaction with (-blockers: Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases. Circulation 1999;99:2268-2275.

Boylan JF, Katz J, Kavanagh BP, Klinck JR, Cheng DCH, DeMajo WC, Walker PM, Johnston KW, Sandler AN: Epidural bupivacaine-morphine analgesia versus patient controlled analgesia following abdominal aortic surgery. Anesthesiology 1998;89:585-593.

Bradley TD, Young T, Strohl KP: American Thoracic Society/American Sleep Disorders Assocation Statement on Health Outcomes Research in Sleep Apnea. Am J Respir Crit Care Med 1998;157:335-341.

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Brooks D, Horner RL, Floras JS, et al: Baroreflex control of heart rate in a canine model of obstructive sleep apnea. Am J Resp Crit Care Med 1999;159:1293-1297.

Byrick RJ, Mullen JB, Murphy PM, Kay CJ, Stewart TE, Edelist G: Inhaled nitric oxide does not alter pulmonary or cardiac effects of fat embolism in dogs after cemented arthroplasty. Can J Anaes 1999;46(6):605-612.

Caldarone CA, Najm H, Kadletz M, Smallhorn JF, Freedom RM, Williams WG, Coles JG: Surgical management of total anomalous pulmonary venous drainage: Impact of coexisting cardiac anomalies. Ann Thorac Surg 1998;66:1521-1526.

Caldarone CA, Najm HK, Kadletz M, Smallhorn JF, Fredom RM, Williams WG, Coles JG: Relentless pulmonary vein stenosis after repair of total anomalous pulmonary venous drainage. Ann Thorac Surg 1998;66:1514-1520.

Campioni E, Nobrega JN, Sefton MV: HEMA-MMA microcapsule implants in hemiparkinsonian rat brain: Biocompatibility assessment using [3H]PK11195 as a marker for gliosis. Biomaterials 1998;19:829-837.

Caramori PRA, Adelman AG, Azevedo ER, Newton GE, Parker AB, Parker JD: Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine. J Am Coll Card 1998;32:1969-1974.

Case P, Lemieux S, Kennedy SH, Lewis GF: Elevated plasma lipids in patients with binge eating disorder are found only in those who are anorexic. Int J Eating Disorders 1999;25(2):187-193.

Cassivi SD, Liu M, Boehler A, Tanswell AK, Slutsky AS, Keshavjee S, Todd TRJ: Transgene expression after adenovirus mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression. J Thorac Cardiovasc Surg 1999;117(1):1-8.

Chan KK, Tsui SKW, Lee SM, Luk SC, Liew CC, Fung KP, Waye M, Lee CY: Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. Gene 1998;210:345-350.

Chan-Yeung M, McClean PA, Sandell PR, Slutsky AS, Zamel N: Sensitization to cat without exposure to cats. Clin Exper Allergy 1999;29(6):762-765.

Chen X, Hassan MO, Jones JV, Sleight P, Floras JS: Baroreflex sensitivity and the blood pressure response to (-blockade. J Human Hypertension 1999;13:185-190.

Cheng DCH: Fast track cardiac surgery pathways; early extubation, process of care, and cost containment. Anesthesiology 1998;88:1429-1433.

Cheng DCH: Impact of early tracheal extubation on hospital discharge. J Cardiothorac Vasc Anesth 1998;12(Suppl.2):35-40.

Chiamvimonvat V, Newman D, Tang A, Green M, Mitchell J, Wulffhart Z, Dorian P: A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitor. J Cardiovasc Pharmacol 1998;32(4):516-520.

Chiumello D, Pristine G, Slutsky AS: Mechanical ventilation affects local and systemic cytokines in an animal model of ARDS. Am J Resp Crit Care Med 1999;160(1):109-116.

Chlorakos A, Langille BL, Adamson SL: Cardiovascular responses attenuate with repeated nitric oxide synthesis inhibition in conscious fetal sheep. Am J Physiol 1998;274:H1472-H1480.

Chockalingham A, Bpharm MB, Campbell N, Cutler H, Drover A, Feldman R, Fodor G, Irvine J, et al: Adherence to management of high blood pressure: Recommendations of the Canadian Coalition for Blood Pressure Control. Can J Public Health, Special Insert 1998;89:I5-I7.

Christakis GT, Buth KJ, Goldman BS, Fremes SE, Rao V, Cohen G, Borger MA, Weisel RD: Inaccurate and misleading valve sizing: A proposed standard for valve size nomenclature. Ann Thorac Surg 1998;66:1198-1203.

Chukkapalli G, Karpik SR, Ethier CR: A scheme for generating unstructured grids on spheres with application to parallel computation. J Computational Physics 1999;149:114-127.

Claudio JO, Liew CC, et al: Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. Genomics 1999;59:85-89.

Claudio JO, Liew CC, et al: Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. Genomics 1998;50:44-52.

Cohen G, Feder-Elituv R, Iazetta J, Bunting P...Fremes SE: Phase 2 studies of adenosine cardioplegia. Circulation 1998;98:225-233.

Cohen G, Shirai T, Weisel RD, Rao V, Merante F, Tumiati LC, Mohabeer MK, Borger MA, Li R-K, Mickle DAG: Optimal myocardial preconditioning in a human model of ischemia and reperfusion. Circ 1998;98(SuppII):184-196.

Cohen G, Shirai T, Weisel RD, Rao V, Merante F, Tumiati LC, Mohabeer MK, Borger MA, Li RD, Mickle DAG: Optimal myocardial preconditioning in humans. Ann NY Acad Sci 1999;874:306-320.

Cole D, Peltekova VD, Rubin L, Hawker GA, Vieth R, Liew CC, Hwang DM, Evrovski J, Hendy GN: A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations. Lancet 1999;353:112-115.

Courtman DW, Cho A, Langille BL, Wilson GJ: Eliminating arterial pulsatile strain by external banding induces medial but not neointimal atrophy and apoptosis in the rabbit. Am J Path 1998;153(6):1723-1729.

Courtman DW, Schwartz SM, Hart CE: Sequential injury of the rabbit abdominal aorta induces intramural coagulation and luminal narrowing independent of intimal mass: Extrinsic pathway inhibition eliminates luminal narrowing. Circ Res 1998;82:996-1006.

Cowan KN, Jones PL, Rabinovitch M: Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C and smooth muscle cell apoptosis. Circ Res 1999;84:1223-1233.

Cregg N, Cheng DCH, et al: Morbidity outcome in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac septal myectomy: Early extubation anesthesia versus high dose narcotic anesthesia. J Cardiothorac Vasc Anesth 1999;13:47-52.

Cronenwett JL, Johnston KW: The united kingdom small aneurysm trial: Implications for surgical treatment of abdominal aortic aneurysms. J Vasc Surg 1998;29:191-194.

Dai KS, Cuckerman E, Liew CC: Characterization of a novel gene encoding zinc finger domains identified from expressed sequence tags (ESTs) of a human heart cDNA database. J Mol Cell Cardiol 1998;30:2365-2375.

DeCampos KN, Keshavjee S, Liu M, Slutsky AS: Prevention of rapid reperfusion-induced lung injury with PGE1 during the initial period of reperfusion. J Heart Lung Transplantation 1998;17(11):1121-1128.

Deliva RM, Ackermann U: Atrial natriuretic peptide and mechanisms of cardiovascular control: Role of serotonergic receptors. Am J Physiol 1998;274:R711-R717.

Devlin GP…Butany J, Richards JA, Sole MJ, Schwartz L: Effect of a single bolus intracoronary basic fibroblast growth factor on perfusion in an ischaemic procine model. Can J Cardiol 1999;15(6):676-682.

Diaz RJ, Losito VA, Ford MA, Backx PH, Wilson GJ: The role of C1 channels in ischemic preconditioning in rabbit heart. Circ Res 1999;84(7):763-775.

Diaz RJ, Losito VA, Ford MK, Mao GD, Backx PH, Wilson GJ: Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circ Res 1999;84:763-775.

Dorian P, Newman D, Greene M: Implantable defibrillators and/or amiodarone: alternatives or complementary therapies. Int J Clin Pract 1998;52(6):425-428.

Dorian P: Interactions between implantable devices and pharmacological agents. Cardiac Electrophysiology Review 1998;2(2):151-153.

Dowd N, Cheng DCH, Karski J, Wong D, Carroll J, Sandler A: Intraoperative awareness in fast track cardiac anesthesia. Anesthesiology 1998;89:1068-1073. (This article was featured in “This Month in Anesthesiology”.) (Selected by the DanneMiller Memorial Educational Foundation to be published in abstract form in Anesthesia File.) (Selected to be published as an abstract in 1999 year book of Anesthesiology and Pain Management.)

Dupuis J, Cernacek P, Tardif J, Stewart DJ, et al: Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension. Am Heart J 1998;135(4):614-620.

Ethier CR, Coloma FM, Sit AJ, Johnson M: Two pore population in the inner wall endothelium of Schlemm’s canal. Invest Ophthalmology and Visual Sci 1998;39:2041-2048.

Ethier CR, Coloma FM: Effects of ethacrynic acid on Schlemm’s canal inner wall and outflow facility in human eyes. Invest Ophthalmology and Visual Science 1999;40:1599-1607.

Ethier CR, Croft MA, Coloma FM, Gangnon R, Ladd B, Kaufman PL: Study of ECA effects on inner wall pores in living monkeys. Invest Ophthalmology and Visual Science 1999;40:1381-1391.

Ethier CR, Steinman D, Zhang X, Karpik SR, Ojha M: Flow waveform effects on end-to-side anastomotic flow patterns. J Biomechanics 1998;31:609-617.

Fisher JA, Sommer LZ, Rucker J, et al: Isocapnic hyperpnea accerates carbon monoxide elimination. Am J Resp Crit Care Med 1999;159(4):1289-1292.

Flalkov JA, Antonyshyn OM, Forrest CR, Farb R: Morphological and volumetric analysis of post-traumatic enophthalmos using combined imaging modalities. IN: Craniofacial Surgery: Proceedings of the VII International Congress of the International Society of Craniofacial Surgery (L. Whitaker, ed). Monduzzi Editore, bologna, Italy, 1998;221-223.

Floras JS: Ambulatory blood pressure monitoring and the taxonomy of hypertension. J Hypertension 1998;16:1719-1720.

Floras JS: Baroreflex sensitivity and heart-rate variability were associated with total cardiac mortality following MI (Commentary). Evidence-Based Cardiovasc Med 1998;2:98-99.

Fodor G, Cutler H, Irvine J, Ramsden V, Tremblay G, Chockalingham A: Adherence to nonpharmacologic therapy for hypertension: Problems and solutions. Can J Public Health, Special Issue 1998;89:I12-I15.

Forrest CR, Pang CY: Discussion: Ischemic preconditioning improves the survival of skin and myocutaneous flaps in a rat model by Kahir KS, Syed SA, Zink JR, Restifo RJ, Thomson JG. Plast Reconstr Surg 1998;109:151-152.

Fried AG, Parker AB, Newton GE, Parker JD: Electrical and hemodynamic correlates of the maximal rate of pressure rise in the human left ventricle. J Card Failure 1999;5:8-16.

Gloviczki P, North American Study Group: Mid-term results of endoscopic perforator vein interruption for chronic venous insufficiency: Lessons learned from the North American subfascial endoscopic perforator surgery registry. J Vasc Surg 1999;29:489-502.

Goodman LS, LeSage S: A tilt table simulation of the push-pull effect. DCIEM Technical Report #1999-023, Defence Research and Development Board, Department of National Defence, 1999.

Gorbet MB, Yeo EL, Sefton MV: A flow cytometric study of in-vitro neutrophil activation by biomaterials. J Biomed Mater Res 1999;44:289-297.

Gur E…Forrest CR: The vascularized pig fibula bone flap model: Effects of multiple segmental osteotomies on growth and viability. Plast Reconstr Surg 1999;103:1436-1450.

Hall MJ, Ando S, Floras JS, Bradley TD: Magnitude and time course of hemodynamic responses to Mueller maneuvers in patients with congestive heart failure. J Appl Physiol 1998;85:1476-1484.

Herridge MS, Slutsky AS, Colditz GA: Has high-frequency ventilation (HFV) been inappropriately discarded in adult ARDS? Crit Care Med 1998;26(12):2073-2077.

Huang WY, Liew CC: Chromatin remodelling of the cardiac beta-myosin heavy chain gene. Biochem J 1998;330:871-876.

Huang WY, Liew CC: Chromatin structure and cardiac gene expression. J Mol Cell Cardiol 1998;30:1673-1681.

Huntington K, Picard P, Moe G, Stewart DJ, Albernaz A, Monge JC: Increased cardiac and pulmonary endothelin-1 mRNA expression in canine pacing-induced heart failure. J Cardiovasc Pharm 1998;31(1):S424-S426.

Jhirad R, Kalman PG: Mycotic axillary artery aneurysm. J Vasc Surg 1998;28:708-709.

Johnston KW: Life expectancy after surgical repair of nonruptured abdominal aortic aneurysm. IN: The Durability of Vascular and Endovascular Surgery. Ed. Greenhalgh RM. W.B. Saunders, London England, 1999, pp135-147.

Jones PL, Jones FS, Zhou B, Rabinovitch M: Denatured type 1 collagen induction of vascular smooth muscle cell tenascin-C gene expression is dependent upon a (3 integrin-mediated mitogen-activated protein kinase pathway and a 122 bp promoter element. J Cell Sci 1999;112:435-445.

Kadokura M, Young DSF, Coles JG, et al: A novel assay for detecting human serum-induced porcine endothelial cell apoptosis. Transplantation Proceeding 1998;30:2938-2940.

Kalman PG, Rappaport DC, Merchant N, Clarke K, Johnston KW: The value of late computed tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm repair. J Vasc Surg 1999;29:442-450.

Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu P, Backx PH: Action potential and [Ca2+]1 changes are related to reduction in Kv4.2 and Kv4.3 currents following myocardial infarction in rat. J Physiol 1999;517:229-245.

Karski JM…Cheng DCH: The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32(C). J Cardiothorac Vasc Anesth 1998;12:642-646.

Kashour T, Schwartz L: Coronary vasospasm as a cause of angina following interventional recanalization. Can J Cardiol 1999;15:605-608.

Kasrai L, Forrest CR, Hearn TC, Szalai JP: A biomechanical analysis of the orbital-zygomatic complex. IN: Craniofacial Surgery: Proceedings of the VII International Congress of the International Society of Craniofacial Surgery (L. Whitaker, ed). Monduzzi Editore, Bologna, Italy, 1998;25-26.

Kasrai L, Hearn T, Gur E, Forrest CR: A biomechanical analysis of the orbital-zygomatic complex in human cadavers: Examination of load-sharing and failure patterns following fixation with titanium and bioresorbable plating systems. J Craniofacial Surg 1999;10:237-243.

Keith M, Geranmayegan A, Sole MJ... Jeejeebhoy KN: Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol 1998;31:1352-1356.

Kerr CR, Boone J, Connolly SJ, Dorian P, et al: The Canadian Registry of Atrial Fibrillation: A non-interventional follow-up of patients following the first diagnosis of atrial fibrillation. Am J Cardiol 1998;82:82N-85N.

Khaykin Y, Dorian P, Tang D, Green M, Mitchell J, Wulffhart Z, Newman D: The effect of sinus node depression on heart rate variability in humans using zatebradine, a selective bradycardic agent. Can J Physiol Pharmacol 1998;76:806-810.

Kirkpatrick AW, Goodman LS, Gray GW, Smith T: Potential aerospace life support systems applications in clinical medicine. DCIEM Technical Report #1999-026, Defence Research and Development Board, Department of National Defence, 1999.

Kok LDS, Tsui SKW, Waye M, Liew CC, Lee CY, Fung KP: Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart. Biochem Biophys Commun 1999;225:717-721.

Lahootti S, Sefton MV: Methods for Microencapsulation with HEMA-MMA. IN: Methods in Molecular Medicine, Vol XX: Tissue Engineering Methods and Protocols. JR Morgan, ML Yamush (Eds). Humana Press Inc, Totowa, New Jersey, 1999;331-348.

Lamarche B, Carpentier A, Uffelman KD, Steiner G, Barrett PHR, Lewis GF: Triglyceride enrichment of HDL enhances the in vivo metabolic clearance of HDL-associated apolipoprotein A-1 in healthy human. J Clin Invest 1999;103:1191-1199.

Lamarche B, Lewis GF: Atherosclerosis prevention for the next decade. Risk assessment beyond LDL cholesterol. Can J Cardiol 1998;14:841-851.

Law A, Wu J, Zeng LH, Wu TW: Aortic endothelia cells damaged by a nitric oxide donor and protected by flavonoids. Life Sciences 1999;64(19):PL199-204.

Lee JK, Zaidi SHE, Liu P, Dawood F, Cheah AYL, Wen WH, Saiki Y, Rabinovitch M: A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function following experimental murine myocarditis. Nature Med 1998;4:1383-1391.

Lee S, Tsui S, Chan K, Garcia-Barcelo M, Wayw M, Fung K, Liew CC, Lee C: Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1). Gene 1998;216:163-170.

Lemieux S, Fontani R, Uffelman KD, Lewis GF, Steiner G: Apolipoprotein B48 and retinyl palmitate are not equivalent markers of postprandial intestinal lipoproteins. J Lipid Res 1998;39:1964-1971.

Leveillee RJ, Pinchuk L, Wilson GJ, Block NL: A new self-expanding lined stent-graft in the dog ureter: Radiological, gross, histopathological and scanning electron microscopic findings. J Urology 1998;160(5):1877-1882.

Lewis GF, Carpentier A, Bilinski D, Giacca A, Vranic M: Counterregulatory response to insulin-induced hypoglycemia differs according to the insulin delivery route. J Clin Endocrinol Metab 1999;84:1037-1046.

Lewis GF, Carpentier A, Vranic M, Giacca A: Resistance to insulin’s acute direct hepatic effect in suppressing steady state glucose production in individuals with Type 2 diabetes mellitus. Diabetes 1999;48:570-576.

Lewis GF, Giacca A, Vranic M, Steiner G: Acute direct and indirect effects of insulin on hepatic glucose and VLDL production. Curr Opinion in Endocrin Diabetes 1998;5:235-245.

Lewis GF, Vranic M, Giacca A: Role of free fatty acids and glucagon in the peripheral effect of insulin on glucose production in humans. Am J Physiol 1998;275:E177-E186.

Li GM, Li R-K, Mickle DAG, Weisel RD, et al: Elevated insulin like growth factor-1 and transforming growth factor B-1 and their receptors in patients with idiopathic hypertrophic obstructive cardiomyopathy: A possible mechanism. Circ 1998;98(SuppII):144-150.

Li K, Stewart DJ, Ward HF: Technology evaluation: Gene therapy (FGF-5), Vical. Current Opinion in Molecular Therapeutics 1999;1(2):260-265.

Li RA, Tsushima RG, Backx PH: Targeting local anesthetics to cardiac Na+ channels. Circ Res 1999;85(1):88-98.

Li R-K, Jia Z-Q, Weisel RD, Merante F, Mickle DAG: Smooth muscle cell transplantation into myocardial scar tissue improves heart function. J Molecular Cell Cardiol 1999;31:513-522.

Liu M…Li R-K, Yan J: Bio-stretch, a computerized cell strain apparatus for three dimensional organotypic cultures. In Vitro Cell Dev Biology 1999;35:87-93.

Lorenze-Filho G, Rankin F, Bies I, Bradley TD: Effects of inhaled CO2 and O2 on Cheyne-Stokes respiration in patients with heart failure. Am J Respir Crit Care Med 1999;159:1490-1498.

Lorenzi-Filho G, Dajani HR, Leung RST, Floras JS, Bradley TD: Entrainment of blood pressure and heart rate oscillations by periodic breathing. Am J Resp Crit Care Med 1999;159:1147-1154.

Losita VA, Tsushima G, Diaz RJ, Wilson GJ, Backx PH: Preferential regulation of rabbit cardiac L-type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway. J Physiol 1998;511(Pt.1):67-78.

Mason CAE...Rabinovitch M: Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nature Med 1999;5:176-188.

Mason TM... Lewis GF, Giacca A: A prolonged elevation of plama free fatty acids desensitises the insulin secretary response to glucose in vivo in rats. Diabetes 1999;48:524-530.

Mehta S, Slutsky AS: Mechanical ventilation in acute respiratory distress syndrome: evolving concepts. Monaldi Arch Chest Dis 1998;53(6):647-653.

Melo LG, Veress AT, Ackermann U, Pang SC, Flynn TG, Sonnenberg H: Chronic hypertension in ANP knockout mice: Contribution of peripheral resistance. Reg Peptides 1999;79:109-115.

Melo LG, Veress AT, Ackermann U, Sonnenberg H: Chronic regulation of arterial blood pressure by ANP: Role of endogenous vasoactive endothelial factors. Am J Physiol 1998;275:H1826-H1833.

Melo LG, Veress AT, Chong CK, Ackermann U, Sonnenberg H: Salt-sensitive hypertension in ANP knockout mice is prevented by AT-1 receptor antagonist Losartan. Am J Physiol 1999;277:R624-R630.

Mentzer R…Weisel RD, Wellons HA, Barker ML, Lasley RD: Adenosine myocardial protection: preliminary results of a phase II clinical trial. Ann Surg 1999;229:643-649.

Merante F, Mickle DAG, Weisel RD, Li R-K, Tumiati LC, Rao V, Williams WG, Robinson BH: Myocardial aerobic metabolism is impaired in a cell culture model of cyanotic heart disease. Am J Physiol 1998;275(Heart Circ Physiol):H1673-H1681.

Milone SD, Newton GE, Parker JD: Hemodynamic and biochemical effects of 100% oxygen breathing in humans. Can J Physiol and Pharmacol 1999;77:124-130.

Milone SD, Pace-Asciak, Reynaud D, Azevedo ER, Newton GE, Parker JD: Biochemical, hemodynamic and vascular evidence concerning the free radical hypothesis of nitrate tolerance. J Cardiovasc Pharm 1999;33:685-690.

Moe G, Albernaz A, Naik GO, Kirchengast M, Stewart DJ: Beneficial effects of long-term selective endothelin A receptor blockade in canine experimental heart failure. Cardiovasc Res 1998;39:571-579.

Moore JA, Steinman DA, Holdsworth DW, Ethier CR: Accuracy of computational hemodynamics in complex arterial geometries reconstructed from MRI. Ann Biomed Engin 1999;27:32-41.

Moore JA, Steinman DA, Prakash S, Johnston KW, Ethier CR: A numerical study of blood flow patterns in anatomically realistic and simplified end-to-side anastomoses. ASME J Biomechanical Eng 1999;121:265-272.

Najm HK, Van Arsdell GS, Watzka S, Hornberger L, Coles JG, Williams WG: Primary repair is superior to initial palliation in children with atrioventricular septal defect and tetralogy of fallot. J Thorac Cardiovasc Surg 1998;116:905-913.

Najm HK, Williams WG, Chuaratanaphong S, Watzka S, Coles JG, Freedom RM: Primum atrial septal defect in children: Early results, risk factors and freedom from reoperation. Ann Thorac Surg 1998;66:829-835.

Naughton MT, Floras JS, Rahman MA, Jamal M, Bradley TD: Respiratory correlates of muscle sympathetic nerve activity in heart failure. Clinical Science 1998;95:277-285.

Newton GE, Azevedo ER, Parker JD: Inotropic and sympathetic responses to the intracoronary infusion of a _2-receptor magonist: A human in vivo study. Circulation 1999;99:2402-2407.

Nguyen QT, Cernacek P, Stewart DJ, Picard P, Rouleau JL: Endothelin-A receptor blockade causes adverse left ventricular remodelling but improves pulmonary artery pressure postinfarction in the rat. Circulation 1998;98:2323-2330.

Nishida O, Arellano R, Cheng DCH, DeMajo W, Kavanagh BP: Gas exchange and hemodynamics in experimental pleural effusion. Crit Care Med, 27:583-587, 1999. (This article was editorial by Dobyns EL: Pleural effusions and hypoxemia. Crit Care Med 1999;27:472.)

Notarius CF, Ando S, Rongen GA, Senn BL, Floras JS: Resting muscle sympathetic nerve activity and peak oxygen uptake in heart failure and normal subjects. Eur Hear J 1999;20:880-887.

Notarius CF, Butler GC, Ando S, Pollard MJ, Senn BL, Floras JS: Dissociation between microneurographic and heart rate variability estimates of sympathetic tone in normal and heart failure subjects. Clinical Science 1999;96:557-565.

Ogilvie RI, Zborowska-Sluis D: Captopril and angiotensin II (AT1) receptor antagonist therapy in a pacing model of heart failure. Can J Cardiol 1998;14:1025-1033.

Ogilvie RI: Isolated systolic hypertension in the elderly – what’s next? Geriatric Nephrology and Urology 1998;8:3-5.

Packer M, Cohn JN... Sole MJ: Consensus recommendations for the management of chronic heart failure. Am J Cardiol 1999;83(2A):1-38A.

Pang CY, Zhang J, Xu H, Lipa J, Forrest CR, Neligan PC: Role and mechanism of endothelin B (ET-B) receptors in mediating ET-1-induced vasoconstriction in pig skin. Am J Physiol 1998;275:R1066.

Park H, Moore J, Trass O, Ojha M: Photochromic grid analysis of vorticity and pressure fields in a 2-D flow field. Experiments in Fluids 1999;26:55-62.

Parker JD, Parker JO: Organic nitrate therapy for stable angina pectoris. N Engl J Med 1998;338:520-531.

Parker JD, Thiessen JJ, et al: Human endothelin-1 clearance kinetics revealed by a radiotracer technique. J Parmacol and Exp Ther 1999;289:261-265.

Picard P... Stewart DJ: Coordinated up-regulation of the cardiac endothelin system in a rat model of heart failure. J Cardiovasc Pharm 1998;31(1):S294-S297.

Pierre AF…Slutsky AS, Keshavjee SH: Rapid reperfusion causes stress failure in ischemic rat lungs. J Thorac Cardiovasc Surg 1998;116(6):932-942.

Pierre AF, Xavier AM, Liu M, Cassivi SD, Lindsay TF, Marsh HC, Slutsky AS, Keshavjee SH: Effect of complement inhibition with soluble complement receptor 1 on pig allotransplant lung function. Transplantation 1998;66(6):723-732.

Pitt B, Waters D, Brown WV, van Bowen AJ, Schwartz L, et al: Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. N Engl J Med 1999;341:70-76.

Prasad N, Ali H, Schwartz L: Short and long term outcome of balloon angioplasty for compromised side branches after intracoronary stent deployment. Cathet Cardiovasc Intervent 1999;46:21-24.

Prie S, Stewart DJ, Dupuis J: ETA receptor blockade improves nitric oxide-mediated vasolilation in monocrotaline-induced pulmonary hypertension. Circulation, 1998;97(21):2169-2174.

Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ: A CT scan assessment of regional lung volume in acute lung injury. Am J Resp Crit Care Med 1998;158(5pt1):1644-1655.

Qi X, Newman D, Dorian P: Azimilide decreases defibrillation voltage requirements and increases spatial organization during ventricular fibrillation. J Interventional Cardiac Electrophysiology 1999;3:61-67.

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Rao V, Komeda M, Weisel RD, Cohen G, Borger M, David TE: Should the pericardium be closed routinely after heart surgery? Ann Thorac Surg 1999;67:484-488.

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ACKNOWLEDGEMENTS:

The Cardiovascular Sciences Collaborative Program would like to thank the following industry sponsors for their generous support.

Bristol-Myers Squibb

Medtronic Canada

Merck Frosst Canada Inc.

Pfizer Canada

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