Advanced Radiotherapy Consulting
Advanced Radiotherapy Consulting Clinical PET Oncology
FDG
F-18
Nonphysiologic
Chemical Structure Similar to that of naturally occurring glucose
FDG & Cancer Cells
Cancer cells use glucose at faster rate
Greater affinity for glucose (membrane transport proteins)
Intracellular enzymes are more active than normal
FDG & Cancer Cells
Varies with the types of cancer
Uptake increases with more aggressive tumors
Increase Glucose Diffusion
Increase rates of glucose phosphorylation
Greater FDG accumulation
FDG: Problems with Uptake
Infection
Inflamation
Atclectasis
Healing Tissues
Muscular Activity
FDG: Issues
Cancer cells that uptake = normal
Cancer remains hidden
Cancer goes unnoticed
Patient Prep / Injection
Do Not Exercise (< 24 hours)
10mCi – 20mCi Injection
20ml-30ml saline flush to ensure no iniltration
Rest for 45-90 min
Patient Prep / Injection
Fast for 4-6 hours
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