Reymundo Dominguez



Reymundo Dominguez

University of Southern California

Neuroscience Graduate Program

Hedco Neuroscience Building, Room 311

3641 Watt Way

Los Angeles, CA 90089-2520

213-740-9189

Personal Information:

Sex: Male

Date of birth: October 18, 1973

Country of origin: U.S. citizen

Ethnicity: Mexican-American

Martial status: Single

Home address: 2348 Altman Street, Los Angeles, CA 90031-1033

Phone number: 323-854-0064

Email: reymundd@usc.edu

Academic Credentials:

PhD in Neuroscience

University of Southern California, Los Angles, CA

Expected date of completion: 2008

MS in Biological Science, 2003

California State University, Los Angeles, CA

BS in Biological Science (emphasis Systems Physiology), minor Chemistry, 1999

San Jose State University, San Jose, CA

AS in Design, 1992

Don Bosco Technical Institute, Rosemead, CA

Current Research Interest:

The study of steroid hormone actions and their links to changes in synaptic plasticity and neuroprotection in the brain. Cellular and Molecular, biochemical, and microscopic imaging techniques are used to study how hormones action modulate brain function in young, adult, and aging rats.

Professional Experience:

Teaching Associate, 2001-2003

Department of Biological Sciences, California State University, Los Angeles, CA

( Undergraduate laboratory instructor for Anatomy & Physiology and Cellular Biology.

Tutor and Mentor, 2000-2001

Elysian Valley United Community Services Center, Los Angeles, CA

( Tutor and mentor inner city students in science and math.

Undergraduate Research Assistant, 1998-99

Department of Biological Sciences, San Jose State University, CA

( Performed laboratory technician task such as cloning, plating, screening colonies, SDS-PAGE, and densitometry; maintained immortal mammalian cell culture and established growth rate and plating efficiency.

Laboratory Instructor and Mentor, 1999

San Jose High Academy of the Sciences, College of Science, San Jose State University, CA

( Instructed and demonstrated science concepts through experimentation and hands on experiences.

Undergraduate Laboratory Assistant, 1998

Department of Biological Sciences, San Jose State University

( Prepared cellular biology experiments and aided students in presenting and discussing experimental results.

Professional Presentations:

Pertussis toxin sensitive G protein mediates estrogen neuroprotection against excitotoxicity. Poster. Society for Neuroscience, Atlanta, GA (2006).

Superoxide dismutase/catalase mimetics are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. Poster. Society for Neuroscience, Atlanta, GA (2006).

Estrogen Signaling Pathways Studied In Cortical Synaptoneurosomes from Rat Brain. Poster. Society for Neuroscience, San Diego, CA (2005).

Estrogen Supports Structural Plasticity of the Basal Forebrain Cholinergic System In Vivo.Poster. Society for Neuroscience, San Diego, CA (2004).

Morphological Effects of Estrogen on Cholinergic Neurons In Vitro Involves Activation of Extracellular Signal-Regulated Kinase. Poster. Society for Neuroscience, New Orleans, LO (2003).

Estrogen Induced Structural Plasticity in Basal Forebrain Cholinergic Neurons. Oral. Southern California Conference on Undergraduate Research (SCCUR), Cal Tech, Pasadena, CA (2002).

Estrogen Has a Potent Effect on Neurite Outgrowth in Cholinergic Neurons. Poster. Society for the Advancement of Chicanos and Native Americans in Science National Conference (SACNAS), Anaheim, CA (2002).

Sexual Dimorphic Characteristics of Basal Forebrain Cholinergic Neurons In Vitro. Poster. 10th Annual Cal State LA, Symposium on Research, Scholarship and Creative Activity, Los Angeles, CA (2002).

Activation of the Mitogen-Activated Protein Kinase Signaling Cascade in Cholinergic Neurons In Vitro. Poster. Southern California Conference on Undergraduate Research (SCCUR), University of California, Los Angeles, CA (2001).

Neurotrophic Effects of Estrogen on the Cholinergic Basal Forebrain. Poster. Southern California Academy of Sciences, California State University, Los Angeles, CA (2001).

Image Analysis of Basal Forebrain Cholinergic Neurons and 17-beta-Estradiol Treatment. Oral. 9th Annual Cal State Student Symposium on Research, Scholarship and Creative Activity, Los Angeles, CA (2001).

Neurotrophic Effects of Estrogen on the Cholinergic Basal Forebrain. Poster. The National Academy of Sciences, the Arthur M. Sackler Colloquia, Washington, D.C. (2001).

Publications:

Dominguez, R., Liu, R., Baudry, M. (in press) 17-ß-Estradiol-mediated activation of extracellular-signal regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3-K)/Akt and NMDA receptor phosphorylation in cortical synaptoneurosomes. Journal of Neurochemistry.

Saenz C., Dominguez R., de Lacalle S. 2006. Estrogen contributes to structural recovery after a lesion. Neuroscience Letters 392(3):198-201

Felix, G., Saenz, C., Dominguez, R., de Lacalle, S. 2005. Estrogen-mediated cholinergic outgrowth. Consejo Superior de Investigaciones Cientificas: Trabajos Del Instituto Cajal, Torino, Italy, p136-137

Dominguez, R., Jalali, C., de Lacalle, S. 2004. Morphological Effects of Estrogen on Cholinergic Neurons In Vitro Involves Activation of Extracellular Signal-Regulated Kinase. Journal of Neuroscience 24(4):982-990

Jalali, C., Dominguez, R., de Lacalle, S. 2003. Structural Plasticity of the Nervous System: the Role of Estrogen. Consejo Superior de Investigaciones Cientificas: Trabajos Del Instituto Cajal, Torino, Italy, p171-172

Research Skills:

Currently I utilize primary neuronal cultures, brain slices, and synaptoneurosomes to study estrogen’s mechanism of action in the cortex and hippocampus.

Digital images and video is acquired using epifluorescence, laser scanning confocal microscopy, and calcium ratio techniques to study synaptic plasticity.

Western blot analysis, cell death assays, transfection (bacterial and viral), fluorescent proteins, and immuno precipitation are used to examine proteins involved in estrogen signaling.

I have also been briefly trained to use electrophysiological techniques; whole cell recording, sharp electrode, and recording field potentials (Neurobiology course 2004, Marine Biological Laboratory, Woods Hole, MA).

Grants Received:

• Training in the Neurobiology and Endocrinology of Aging Predoctoral Fellowship (AG14751 PI: C. Finch)

( American Society for Cell Biology (ASCB) Scholarship, Minority Affairs Committee, 2004

( William Townsend Porter Fellowship, 2004

( Neuroscience Graduate Program Scholarship, 2004

( Provost’s Neuroscience Graduate Fellowship, 2003-2004

( Minority Biomedical Research Support-Research Initiative for Scientific Enhancement (MBRS-RISE), MS-to-PhD fellowship, 2000-2003

( National Science Foundation (NSF), Alliance for Minority Participation (AMP) Scholarship, 1997-98

( President Clinton’s National Summer of Service (SOS) Scholarship, 1993

Honors and Awards:

( Graduate student honor award, CSULA, 2001-2003

( The Endocrine Society’s award for an outstanding project, 2002

( First place winner, 10th Annual Cal State LA, Symposium on Research, Scholarship and Creative Activity, 2002

( San Jose State University Leadership Award, 1996

( Boy Scouts of America, Eagle Scout Award, 1991

Professional Memberships:

( Society for Advancement of Chicanos and Native Americans in Science (SACNAS), student member #10989

( Society for Neuroscience (SfN), member identification # 100016805

( The Endocrine Society, Fellow/Student Associate, member ID # 210157

Volunteer

( Brain Awareness Week, USC 2003-2005

( East Los Angeles Kids Judge Fair, Brain Awareness Week, Exhibitor, 2003

( Minority Options in Research Education (MORE)-MBRS graduate student representative, 2001-2002

References:

Michel Baudry, PhD

Professor

University of Southern California

Neuroscience Program, HNB532

Los Angeles, CA 90089-2520

213-740-9188 baudry@usc.edu

Richard Thompson, PhD

Professor

University of Southern California

Neuroscience Program, HNB522

Los Angeles, CA 90089-2520

213-740-7350 thompson@usc.edu

Sonsoles de Lacalle, MD/PhD

Associate Professor

Department of Biomedical Sciences

Charles R. Drew University of Medicine and Science

Los Angeles, CA 90059

323-563-5853 sdelacalle@

Raymond E. Garcia, PhD

Professor

California State University, Los Angeles

Department of Chemistry and Biochemistry, PS 516

5151 State University Drive

Los Angeles, CA 90032

2144. rgarcia@calstatela.edu

Edwin McCleskey, PhD

Associate Professor

Oregon Health Science University

Vollum Institute, Room 2419A

3181 SW Sam Jackson Park Road

Portland, OR 97239-3098

503-494-6933 mccleske@ohsu.edu

Adrian Rodriguez, PhD

Associate Professor

San Jose State University, DH 254

Department of Biology

One Washington Square

San Jose, CA 95192

408-924-4846 rodriga@sjsu.edu

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