UKMi Q&A xx - SPS
The state of hydration of a patient will affect the volume of distribution (Vd) of water soluble drugs with a small Vd e.g. aminoglycosides with a Vd of approximately 0.25L/kg (2, 8). In patients with conditions such as sepsis, major burn injury etc., oedema formation and administration of IV fluids leads to an increase in total body water thus ... ................
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