What factors need to be considered when dosing patients ...

The state of hydration of a patient will affect the volume of distribution (Vd) of water soluble drugs with a small Vd (2) e.g. aminoglycosides with a Vd of approximately 0.25L/kg (7). In patients with conditions such as sepsis, major burn injury etc., oedema formation and administration of IV fluids leads to an increase in total body water ... ................
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