Eosinophilic lung disease
Eosinophilic lung disease
Dr Patrick Dennison Consultant Respiratory/GIM
Overview
? Some definitions... ? Non-pulmonary eosinophilia ? Eosinophilic lung diseases ? Diagnostic work-up
Common scenarios
? "Hello, it's the ITU SpR here, we've got a patient, really sick, being treated for infection, not getting better, he's got a weird CT with a broad differential and we've just noticed his eosinophils are up, should we pulse him with steroids? (Oh and we've called the rheumatologists as well)"
? "Hmm, that eosinophil count is randomly high on the take ? oh look, it's been high for a while, what's doing that?"
Some definitions
? Peripheral blood eosinophilia
? >5-600 cells/L (mild) ? >1500 cells/L (moderate) ? > 5000 (severe)
? BAL eosinophilia
? >5% eosinophils
? Tissue eosinophilia
? Tissue infiltration that is extensive +/- deposition EGP
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