Autoimuninės kilmės glomerulų pažeidimas

VILNIUS UNIVERSITY

Autoimunins kilms glomerul pazeidimas

Prof. Arvydas Laurinavicius Vilnius 2018-04-13

Autoiminins kilms glomerul pazeidimas

? ANTI-GBM GLOMERULONEFRITAS, GOODPASTURE SINDROMAS ? ANCA VASKULITAI ? VILKLIGINIS (LUPUS) NEFRITAS ? KITI IMUNOKOMPLEKSINIAI

? ,,IDIOPATINIS" MEMBRANOPROLIFERACINIS GN ? MEMBRANIN NEFROPATIJA (fosfolipazs A2 receptoriai)

? C3 GLOMERULOPATIJOS ? TROMBINS MIKROANGIOPATIJOS (AFAS IR KT.)

2

Nephropathology map

Minimal change NS FSGS

Idiopathic Drugs

primary

NSAID

Nephrotic

secondary Membranous nephropathy

Antibiotics other

sudden onset

Endocapillary GN

Malignancy

insidious

Crescentic GN anti-GBM

Carcinoma Lymphoproliferative

Nephritic

pauci-immune

other

acute

immune-complex Membranoproliferative

Autoimmune ANCA

subacute (RPGN)

immune-complex

Anti-GBM

chronic

biopsija

Proteinuria subnephrotic

cryoglobulin DDD/C3 GN paraprotein

atsakymas

SLE Anti-phospholipid RA

Hematuria

TMA Mesangioproliferative

SS other

persistent micro

IgA nephropathy

Bacterial infections

recurrent macro

GBM abnormalities Alport

Acute Streptococcal Persistent other

Renal insufficiency

IssamiPdatihaolgognioc TazcBcMuomDpultaitmionasliam

gydymVuiiral

infections HBV

acute

Amyloid

HCV

chronic

Diabetic glomerulosclerosis

HIV

Arterial hypertension

Fabry Myeloma kidney

other Hereditary

Other systems involved

Oxalosis

Other kidney disease

Tubular, Interstitial, Vascular injury

Other disease

Nephrotic sudden onset insidious

Nephritic acute subacute (RPGN) chronic

Proteinuria subnephrotic Hematuria

persistent micro recurrent macro Renal insufficiency acute chronic Arterial hypertension Other systems involved

Minimal change NS FSGS

primary secondary Membranous nephropathy Endocapillary GN Crescentic GN anti-GBM pauci-immune immune-complex Membranoproliferative immune-complex cryoglobulin DDD/C3 GN paraprotein TMA Mesangioproliferative IgA nephropathy GBM abnormalities Alport TBMD Pathologic accumulations

Amyloid ???

Diabetic glomerulosclerosis Fabry Myeloma kidney Oxalosis Tubular, Interstitial, Vascular injury

Idiopathic Drugs

NSAID Antibiotics other Malignancy Carcinoma Lymphoproliferative other Autoimmune ANCA Anti-GBM SLE Anti-phospholipid RA SS other Bacterial infections Acute Streptococcal Persistent other Viral infections HBV HCV HIV other Hereditary Other kidney disease Other disease

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