AP Chemistry
Heterocyclic Synthesis. Pyridine ***** Ring Synthesis. 1) The Hantzsch Synthesis. 1,3-dicarbonyl compound + ammonia + aldehyde 2) Reaction of Ammonia + 1,5-diketone 3) Diels-Alder Reaction. 4) Kroehnke Synthesis Chemistry of Pyridine. a) Reaction at nitrogen. Electrophilic Substitution. Pyridine is million times less reactive than benzene ................
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