Standard Operating Procedures
Standard Operating Procedure
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Read the EH&S Standard Operating Procedures Fact Sheet before filling out this form. Print out the completed form and keep a readily accessible hard copy in the lab (also keeping an electronic copy is highly recommended).
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Date: November 4, 2010
SOP Title: Titanium Tetrachloride (TiCl4)
Principal Investigator: Richmond Sarpong
Room and Building: 841A Latimer
Lab Phone Number: (510) 643-2485
Section 1 – Process
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Section 2 – Hazardous Chemicals
|Titanium tetrachloride is extremely moisture sensitive and reacts violently with air and/or water. Upon reaction with water TiCl4 will also liberate|
|highly toxic gases (HCl gas). |
Section 3 – Potential Hazards
|TiCl4 is reacts violently upon exposure to water, and as such can be purchased as solutions in an organic solvent. They must be handled under an |
|inert atmosphere to minimize exposure to both air and moisture. Inhalation of gases released upon contact with moisture will cause destruction of |
|the tissue of the mucous membranes and may be fatal. Contact with the skin will cause severe burns and contact with the eyes will cause damage. |
|TiCl4 may also be harmful if absorbed through the skin. |
Section 4 – Approvals Required
|Use of titanium tetrachloride reagents requires training and the approval of the appropriate lab member. |
Section 5 – Designated Area
|Titanium tetrachloride should only be used in the fume hood. Additionally, it should be stored under |
|inert atmosphere. |
Section 6 – Special Handling Procedures and Storage Requirements
|Clear all areas where the reagent will be opened prior to use. Do not use any titanium tetrachloride while working alone. |
| |
|There are two options for the handling of titanium tetrachloride. The first option is the use of a syringe and needle; the second is to transfer using |
|a cannula. For smaller amounts of reagent, the preferred technique is to use a syringe and needle, while a cannula transfer is safer and more practical|
|for amounts >15 mL. See .com/ etc/medialib/docs/Aldrich/Bulletin/ altechbullal134.Par.0001.File.tmp/al_techbull_al134.pdf for a|
|detailed procedure on proper Schlenk technique. |
| |
|Proper syringe/needle transfer is as follows: All glassware and solvents should be dried prior to the treatment with any titanium tetrachloride. |
|Flame-dried glassware which has been cooled under an inert atmosphere just before use is ideal. Upon charging a dry flask with dry reagents/solvents |
|and reaching the desired temperature, the titanium tetrachloride can be added. Titanium tetrachloride is often stored under refrigeration and must be |
|warmed to room temperature prior to use. |
| |
|Titanium tetrachloride is contained in a Sure-Seal bottle, the septum of which can be pierced by clean, dry needle fitted to a Schlenk line which is |
|supplying an inert gas. This line is used to keep the reagent under a blanket of inert gas during the entire process. The inert gas flow is adjusted |
|by monitoring of the oil bubbler on the Schlenk line. A clean, dry reagent needle ( ................
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