Standard Operating Procedures



Standard Operating Procedure

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Read the EH&S Standard Operating Procedures Fact Sheet before filling out this form. Print out the completed form and keep a readily accessible hard copy in the lab (also keeping an electronic copy is highly recommended).

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Date: November 4, 2010

SOP Title: Titanium Tetrachloride (TiCl4)

Principal Investigator: Richmond Sarpong

Room and Building: 841A Latimer

Lab Phone Number: (510) 643-2485

Section 1 – Process

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Section 2 – Hazardous Chemicals

|Titanium tetrachloride is extremely moisture sensitive and reacts violently with air and/or water. Upon reaction with water TiCl4 will also liberate|

|highly toxic gases (HCl gas). |

Section 3 – Potential Hazards

|TiCl4 is reacts violently upon exposure to water, and as such can be purchased as solutions in an organic solvent. They must be handled under an |

|inert atmosphere to minimize exposure to both air and moisture. Inhalation of gases released upon contact with moisture will cause destruction of |

|the tissue of the mucous membranes and may be fatal. Contact with the skin will cause severe burns and contact with the eyes will cause damage. |

|TiCl4 may also be harmful if absorbed through the skin. |

Section 4 – Approvals Required

|Use of titanium tetrachloride reagents requires training and the approval of the appropriate lab member. |

Section 5 – Designated Area

|Titanium tetrachloride should only be used in the fume hood. Additionally, it should be stored under |

|inert atmosphere. |

Section 6 – Special Handling Procedures and Storage Requirements

|Clear all areas where the reagent will be opened prior to use. Do not use any titanium tetrachloride while working alone. |

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|There are two options for the handling of titanium tetrachloride. The first option is the use of a syringe and needle; the second is to transfer using |

|a cannula. For smaller amounts of reagent, the preferred technique is to use a syringe and needle, while a cannula transfer is safer and more practical|

|for amounts >15 mL. See .com/ etc/medialib/docs/Aldrich/Bulletin/ altechbullal134.Par.0001.File.tmp/al_techbull_al134.pdf for a|

|detailed procedure on proper Schlenk technique. |

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|Proper syringe/needle transfer is as follows: All glassware and solvents should be dried prior to the treatment with any titanium tetrachloride. |

|Flame-dried glassware which has been cooled under an inert atmosphere just before use is ideal. Upon charging a dry flask with dry reagents/solvents |

|and reaching the desired temperature, the titanium tetrachloride can be added. Titanium tetrachloride is often stored under refrigeration and must be |

|warmed to room temperature prior to use. |

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|Titanium tetrachloride is contained in a Sure-Seal bottle, the septum of which can be pierced by clean, dry needle fitted to a Schlenk line which is |

|supplying an inert gas. This line is used to keep the reagent under a blanket of inert gas during the entire process. The inert gas flow is adjusted |

|by monitoring of the oil bubbler on the Schlenk line. A clean, dry reagent needle ( ................
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